DE69024970T2 - Verfahren zur herstellung eines werkstoffes für osteoplastik aus natürlichem knochengewebe sowie aus solchem verfahren gewonnenes material - Google Patents
Verfahren zur herstellung eines werkstoffes für osteoplastik aus natürlichem knochengewebe sowie aus solchem verfahren gewonnenes materialInfo
- Publication number
- DE69024970T2 DE69024970T2 DE69024970T DE69024970T DE69024970T2 DE 69024970 T2 DE69024970 T2 DE 69024970T2 DE 69024970 T DE69024970 T DE 69024970T DE 69024970 T DE69024970 T DE 69024970T DE 69024970 T2 DE69024970 T2 DE 69024970T2
- Authority
- DE
- Germany
- Prior art keywords
- bone tissue
- osteoplastic
- natural bone
- producing
- given
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8915363A FR2654625B1 (fr) | 1989-11-22 | 1989-11-22 | Procede de fabrication d'un materiau pour osteoplastie a partir d'un tissu osseux naturel et materiau obtenu par ce procede. |
PCT/FR1990/000842 WO1991007194A1 (fr) | 1989-11-22 | 1990-11-22 | Procede de fabrication d'un materiau pour osteoplastie a partir d'un tissu osseux naturel et materiau obtenu par ce procede |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69024970D1 DE69024970D1 (de) | 1996-02-29 |
DE69024970T2 true DE69024970T2 (de) | 1996-09-12 |
Family
ID=9387674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69024970T Expired - Fee Related DE69024970T2 (de) | 1989-11-22 | 1990-11-22 | Verfahren zur herstellung eines werkstoffes für osteoplastik aus natürlichem knochengewebe sowie aus solchem verfahren gewonnenes material |
Country Status (19)
Country | Link |
---|---|
US (1) | US5585116A (de) |
EP (1) | EP0502055B1 (de) |
JP (1) | JP3101739B2 (de) |
KR (1) | KR0169328B1 (de) |
CN (1) | CN1076962C (de) |
AT (1) | ATE133076T1 (de) |
AU (1) | AU6885891A (de) |
BR (1) | BR9007861A (de) |
CA (1) | CA2069450C (de) |
DE (1) | DE69024970T2 (de) |
DK (1) | DK0502055T3 (de) |
ES (1) | ES2084713T3 (de) |
FR (1) | FR2654625B1 (de) |
GR (1) | GR3019166T3 (de) |
OA (1) | OA09699A (de) |
PT (1) | PT95955B (de) |
RU (1) | RU2104703C1 (de) |
TR (1) | TR25032A (de) |
WO (1) | WO1991007194A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2699408B1 (fr) * | 1992-12-21 | 1995-03-24 | Bioland | Procédé de traitement de tissus osseux et biomatériaux implantables correspondants. |
US5782919A (en) | 1995-03-27 | 1998-07-21 | Sdgi Holdings, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
US6206922B1 (en) | 1995-03-27 | 2001-03-27 | Sdgi Holdings, Inc. | Methods and instruments for interbody fusion |
US5868749A (en) * | 1996-04-05 | 1999-02-09 | Reed; Thomas M. | Fixation devices |
FR2752382B1 (fr) * | 1996-08-16 | 1998-10-09 | Assist Publ Hopitaux De Paris | Procede de traitement de produits d'origine humaine ou animale destines a une utilisation therapeutique |
US5782914A (en) * | 1996-11-29 | 1998-07-21 | Bio-Vascular, Inc. | Method for preparing heterogeneous tissue grafts |
US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
US6511509B1 (en) | 1997-10-20 | 2003-01-28 | Lifenet | Textured bone allograft, method of making and using same |
US6080579A (en) * | 1997-11-26 | 2000-06-27 | Charlotte-Mecklenburg Hospital Authority | Method for producing human intervertebral disc cells |
US7101545B1 (en) | 1997-11-26 | 2006-09-05 | Charlotte-Mecklenburg Hospital Authority | Method for using human intervertebral disc cells |
US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US6123731A (en) * | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
KR100393469B1 (ko) * | 1999-01-02 | 2003-08-06 | 정필훈 | 동물 뼈를 이용한 골 대체물 제조방법 |
US6206923B1 (en) * | 1999-01-08 | 2001-03-27 | Sdgi Holdings, Inc. | Flexible implant using partially demineralized bone |
US6113638A (en) * | 1999-02-26 | 2000-09-05 | Williams; Lytton A. | Method and apparatus for intervertebral implant anchorage |
US6921412B1 (en) | 1999-05-18 | 2005-07-26 | Cryolife, Inc. | Self-supporting, shaped, three-dimensional biopolymeric materials and methods |
EP1202756A1 (de) * | 1999-07-28 | 2002-05-08 | Regeneration Technologies, Inc. | Gewebeimplantate mit reduzierter antigenität |
FR2798294B1 (fr) * | 1999-09-10 | 2001-10-12 | Ost Dev | Procede de fabrication d'un materiau de prothese osseuse par traitement d'un tissu osseux naturel |
US6379385B1 (en) | 2000-01-06 | 2002-04-30 | Tutogen Medical Gmbh | Implant of bone matter |
DE10026306A1 (de) * | 2000-05-26 | 2001-11-29 | Tutogen Medical Gmbh | Transplantat |
US7018416B2 (en) | 2000-07-06 | 2006-03-28 | Zimmer Spine, Inc. | Bone implants and methods |
KR100362699B1 (ko) * | 2000-08-28 | 2002-11-27 | 주식회사 오스코텍 | 칼슘 포스페이트 초박막 코팅된 우골 분말 |
US6432436B1 (en) | 2000-10-03 | 2002-08-13 | Musculoskeletal Transplant Foundation | Partially demineralized cortical bone constructs |
WO2002085284A2 (en) * | 2000-11-07 | 2002-10-31 | Cryolife, Inc. | Expandable foam-like biomaterials and methods |
WO2002098332A1 (en) * | 2001-02-16 | 2002-12-12 | Sulzer Spine-Tech Inc. | Bone implants and methods |
DE10157182A1 (de) * | 2001-11-22 | 2003-06-05 | Matricel Gmbh | Verfahren zur Behandlung von Materialien biologischen Ursprungs und Elastin-Produkt |
US7708776B1 (en) | 2002-01-16 | 2010-05-04 | Nuvasive, Inc. | Intervertebral disk replacement system and methods |
US7264966B2 (en) * | 2002-01-23 | 2007-09-04 | Olympus Optical Co., Ltd. | Method of isolating cell or sample to be analyzed in cell |
US6890354B2 (en) | 2002-03-08 | 2005-05-10 | Musculoskeletal Transplant Foundation | Bone-tendon-bone assembly with allograft bone block and method for inserting same |
US6730124B2 (en) | 2002-03-08 | 2004-05-04 | Musculoskeletal Transplant Foundation | Bone-tendon-bone assembly with cancellous allograft bone block |
ATE487444T1 (de) | 2002-03-30 | 2010-11-15 | Infinity Orthopaedics Company | Medizinische intervertebrale vorrichtung |
US20060204544A1 (en) * | 2002-05-20 | 2006-09-14 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
WO2004067050A1 (en) * | 2003-01-28 | 2004-08-12 | Osteotech, Inc. | Tissue pathogen inactivation/removal process |
US20050266037A1 (en) * | 2004-05-25 | 2005-12-01 | Agency For Science, Technology & Research, A Comp. Organized & Existing Under The Laws Of Singapore | Implantable biomaterial and method for the preparation thereof |
US7618459B2 (en) | 2005-09-26 | 2009-11-17 | Infinity Orthopedics Ltd. | Universal spinal disc implant system |
US8241673B2 (en) | 2005-10-27 | 2012-08-14 | Dmitry Alekseevich Savaschuk | Method for producing biomaterials from bone tissue and material used for osteoplasty and tissue engineering |
US8685092B2 (en) | 2005-10-27 | 2014-04-01 | Andrey Fedorovich Panasyuk | Material for osteoplasty and tissue engineering |
US7892577B2 (en) * | 2006-02-27 | 2011-02-22 | Globus Medical, Inc. | Bone graft materials derived from mineralized gelatin |
US8784477B2 (en) | 2011-01-05 | 2014-07-22 | Abbott Cardiovascular Systems Inc. | Stent graft with two layer ePTFE layer system with high plasticity and high rigidity |
US7785634B2 (en) * | 2006-02-27 | 2010-08-31 | Globus Medical, Inc. | Bone graft materials derived from mineralized gelatin |
US8043377B2 (en) | 2006-09-02 | 2011-10-25 | Osprey Biomedical, Inc. | Implantable intervertebral fusion device |
FR2922434B1 (fr) * | 2007-10-18 | 2010-08-20 | Rech S Et De Fabrication Serf | Implant dentaire |
CN101496914B (zh) * | 2008-02-03 | 2012-06-27 | 烟台正海生物技术有限公司 | 骨支架材料及其制备方法与应用 |
CN107412864A (zh) | 2009-12-13 | 2017-12-01 | 阿米特·普拉卡什·戈维 | 生物活性移植物和复合物 |
US9585764B2 (en) * | 2012-07-26 | 2017-03-07 | Warsaw Orthopedic, Inc. | Bone implant device |
JP5879459B2 (ja) * | 2012-07-31 | 2016-03-08 | ガイストリヒ・ファーマ・アクチェンゲゼルシャフトGeistlich Pharma Ag | 親水性のホスフェートグループを含有する脱水された部分的に精製された骨置換材料 |
ITVI20120210A1 (it) * | 2012-08-10 | 2014-02-11 | Akimedix S R L | Un processo per la realizzazione di un rivestimento biocompatibile per impianti ossei con materiale base estratto da osso di mammifero, nonche' rivestimento ed impianto ottenuti |
RU2517037C1 (ru) * | 2013-02-08 | 2014-05-27 | Евгений Викторович Ларионов | Способ получения костного минерального компонента и костный минеральный компонент для замещения и восстановления дефектов костной ткани |
RU2640932C2 (ru) * | 2016-07-04 | 2018-01-12 | Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт травматологии и ортопедии им. Я.Л. Цивьяна" Министерства здравоохранения Российской Федерации (ФГБУ "ННИИТО им. Я.Л. Цивьяна" Минздрава России) | Способ получения костно-пластического материала |
RU2665962C1 (ru) * | 2017-03-17 | 2018-09-05 | Общество с ограниченной ответственностью "Матрифлекс" | Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения |
US11285177B2 (en) | 2018-01-03 | 2022-03-29 | Globus Medical, Inc. | Allografts containing viable cells and methods thereof |
CN111494715B (zh) * | 2020-04-17 | 2022-03-29 | 东南大学 | 一种高分子填充骨材料及其制备方法 |
FR3110386A1 (fr) | 2020-05-20 | 2021-11-26 | Univ Paris Xiii Paris-Nord Villetaneuse | Matériau de substitution osseux poreux |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3318774A (en) * | 1961-03-15 | 1967-05-09 | Squibb & Sons Inc | Treatment of osseous and other tissue |
FR1317584A (fr) * | 1961-03-15 | 1963-02-08 | Olin Mathieson | Méthode de traitement des tissus osseux et autres tissus |
US4440750A (en) * | 1982-02-12 | 1984-04-03 | Collagen Corporation | Osteogenic composition and method |
US4485097A (en) * | 1982-05-26 | 1984-11-27 | Massachusetts Institute Of Technology | Bone-equivalent and method for preparation thereof |
US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
US4678470A (en) * | 1985-05-29 | 1987-07-07 | American Hospital Supply Corporation | Bone-grafting material |
US4627853A (en) * | 1985-05-29 | 1986-12-09 | American Hospital Supply Corporation | Method of producing prostheses for replacement of articular cartilage and prostheses so produced |
US5053049A (en) * | 1985-05-29 | 1991-10-01 | Baxter International | Flexible prostheses of predetermined shapes and process for making same |
US5290558A (en) * | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
US5073373A (en) * | 1989-09-21 | 1991-12-17 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
-
1989
- 1989-11-22 FR FR8915363A patent/FR2654625B1/fr not_active Expired - Fee Related
-
1990
- 1990-11-20 CN CN90109859A patent/CN1076962C/zh not_active Expired - Fee Related
- 1990-11-21 PT PT95955A patent/PT95955B/pt not_active IP Right Cessation
- 1990-11-21 TR TR90/1109A patent/TR25032A/xx unknown
- 1990-11-22 JP JP03500180A patent/JP3101739B2/ja not_active Expired - Fee Related
- 1990-11-22 CA CA002069450A patent/CA2069450C/fr not_active Expired - Fee Related
- 1990-11-22 ES ES90917465T patent/ES2084713T3/es not_active Expired - Lifetime
- 1990-11-22 AU AU68858/91A patent/AU6885891A/en not_active Abandoned
- 1990-11-22 RU SU5052240A patent/RU2104703C1/ru not_active IP Right Cessation
- 1990-11-22 KR KR1019920701061A patent/KR0169328B1/ko not_active IP Right Cessation
- 1990-11-22 AT AT90917465T patent/ATE133076T1/de not_active IP Right Cessation
- 1990-11-22 DK DK90917465.8T patent/DK0502055T3/da active
- 1990-11-22 DE DE69024970T patent/DE69024970T2/de not_active Expired - Fee Related
- 1990-11-22 BR BR909007861A patent/BR9007861A/pt unknown
- 1990-11-22 WO PCT/FR1990/000842 patent/WO1991007194A1/fr active IP Right Grant
- 1990-11-22 EP EP90917465A patent/EP0502055B1/de not_active Expired - Lifetime
-
1992
- 1992-05-22 OA OA60211A patent/OA09699A/fr unknown
-
1995
- 1995-02-03 US US08/383,654 patent/US5585116A/en not_active Expired - Lifetime
-
1996
- 1996-02-29 GR GR960400567T patent/GR3019166T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU6885891A (en) | 1991-06-13 |
EP0502055B1 (de) | 1996-01-17 |
EP0502055A1 (de) | 1992-09-09 |
CA2069450C (fr) | 2001-08-28 |
WO1991007194A1 (fr) | 1991-05-30 |
JP3101739B2 (ja) | 2000-10-23 |
JPH05501975A (ja) | 1993-04-15 |
OA09699A (fr) | 1993-08-30 |
ES2084713T3 (es) | 1996-05-16 |
GR3019166T3 (en) | 1996-05-31 |
CN1052430A (zh) | 1991-06-26 |
ATE133076T1 (de) | 1996-02-15 |
RU2104703C1 (ru) | 1998-02-20 |
TR25032A (tr) | 1992-09-01 |
FR2654625A1 (fr) | 1991-05-24 |
KR0169328B1 (ko) | 1999-01-15 |
DK0502055T3 (da) | 1996-05-20 |
PT95955A (pt) | 1991-09-13 |
BR9007861A (pt) | 1992-09-29 |
CN1076962C (zh) | 2002-01-02 |
DE69024970D1 (de) | 1996-02-29 |
US5585116A (en) | 1996-12-17 |
PT95955B (pt) | 1998-01-30 |
FR2654625B1 (fr) | 1992-02-21 |
CA2069450A1 (fr) | 1991-05-23 |
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