DE69022254D1 - Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes. - Google Patents

Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes.

Info

Publication number
DE69022254D1
DE69022254D1 DE69022254T DE69022254T DE69022254D1 DE 69022254 D1 DE69022254 D1 DE 69022254D1 DE 69022254 T DE69022254 T DE 69022254T DE 69022254 T DE69022254 T DE 69022254T DE 69022254 D1 DE69022254 D1 DE 69022254D1
Authority
DE
Germany
Prior art keywords
ligand
receptor
analogue conjugate
target
fluid sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69022254T
Other languages
English (en)
Other versions
DE69022254T2 (de
Inventor
Kenneth Francis Buechler
Gunars E Valkirs
Richard Ray Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere San Diego Inc
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Application granted granted Critical
Publication of DE69022254D1 publication Critical patent/DE69022254D1/de
Publication of DE69022254T2 publication Critical patent/DE69022254T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
DE69022254T 1989-01-10 1990-01-10 Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes. Expired - Lifetime DE69022254T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/295,568 US5028535A (en) 1989-01-10 1989-01-10 Threshold ligand-receptor assay

Publications (2)

Publication Number Publication Date
DE69022254D1 true DE69022254D1 (de) 1995-10-19
DE69022254T2 DE69022254T2 (de) 1996-02-15

Family

ID=23138252

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69022254T Expired - Lifetime DE69022254T2 (de) 1989-01-10 1990-01-10 Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes.

Country Status (12)

Country Link
US (3) US5028535A (de)
EP (1) EP0378391B1 (de)
JP (1) JP2807565B2 (de)
AT (1) ATE127921T1 (de)
AU (1) AU633874B2 (de)
CA (1) CA2007532C (de)
DE (1) DE69022254T2 (de)
DK (1) DK0378391T3 (de)
ES (1) ES2079434T3 (de)
GR (1) GR3018366T3 (de)
PT (1) PT92828B (de)
WO (1) WO1990008319A1 (de)

Families Citing this family (312)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3842702A1 (de) * 1988-12-19 1990-06-21 Boehringer Mannheim Gmbh Testtraeger zur analytischen untersuchung einer probenfluessigkeit mit hilfe einer spezifischen bindungsreaktion zweier bioaffiner bindungspartner und entsprechendes testverfahren
US5939272A (en) * 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US6352863B1 (en) 1990-01-19 2002-03-05 La Mina, Inc. Assay device
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
DE69119312T2 (de) * 1990-07-18 1997-01-16 Abbott Lab Analyt-Austauschreagenz zur Verwendung in spezifischen Bindungstests, -vorrichtungen und -sätzen
US5143852A (en) * 1990-09-14 1992-09-01 Biosite Diagnostics, Inc. Antibodies to ligand analogues and their utility in ligand-receptor assays
WO1992005282A1 (en) * 1990-09-14 1992-04-02 Biosite Diagnostics, Inc. Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
CA2056698A1 (en) * 1990-12-11 1992-06-12 John L. Palmer Assay, employing analog to digital signaling, for the presence of an analyte in a sample in conjunction with a binding component, apparatus for performing said process, and a method of performing said assay
EP0579767B1 (de) * 1991-04-11 2000-08-23 Biosite Diagnostics Inc. Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden
US5877028A (en) 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US5998220A (en) 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
US5451504A (en) * 1991-07-29 1995-09-19 Serex, Inc. Method and device for detecting the presence of analyte in a sample
EP0600936B1 (de) * 1991-07-29 1999-10-06 Serex, Inc. Differentielle bindungsaffinitäten und darauf beruhende dissoziationstestverfahren
WO1993007474A1 (en) * 1991-10-09 1993-04-15 Hawaii Chemtect International Field kit for detecting analytes
US5623053A (en) * 1992-01-10 1997-04-22 California Institute Of Technology Soluble mammal-derived Fc receptor which binds at a pH ranging from about 5.5 to 6.5 and releases at a pH ranging from about 7.5 to 8.5
JPH07503540A (ja) * 1992-01-22 1995-04-13 アボツト・ラボラトリーズ 半定量結合検定用校正試薬および装置
US5541069A (en) * 1992-02-28 1996-07-30 Quidel Corporation Assay having improved dose response curve
WO1993020448A1 (en) * 1992-04-01 1993-10-14 The Regents Of The University Of California Non-instrumented enzyme immunoassay: general method utilizing kinetic binding effects
US5885527A (en) * 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US7524456B1 (en) 1992-05-21 2009-04-28 Biosite Incorporated Diagnostic devices for the controlled movement of reagents without membranes
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6767510B1 (en) 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6905882B2 (en) * 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
CA2096495C (en) * 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
WO1994008238A1 (en) * 1992-09-28 1994-04-14 Biex, Inc. Method for prediction of premature labor
CA2150680A1 (en) * 1992-12-01 1994-06-23 Stephen B. Friedman A petroleum immunoassay method, its components and a kit for use in performing the same
FI96143C (fi) * 1993-03-16 1996-05-10 Wallac Oy Biospesifinen määritysmenetelmä
US7083984B2 (en) 1993-09-24 2006-08-01 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US7322927B2 (en) 1993-09-24 2008-01-29 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US5824799A (en) * 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
US5589344A (en) * 1994-06-15 1996-12-31 Johnson & Johnson Clinical Diagnostics, Inc. Test kit and method for competitive specific binding assay
US6653066B1 (en) 1994-06-17 2003-11-25 Trinity Biotech Device and method for detecting polyvalent substances
WO1996003929A1 (en) * 1994-08-04 1996-02-15 Biex, Inc. Method for prediction of premature delivery using estetrol (e4) as an indicator
US5521102A (en) * 1994-08-08 1996-05-28 Quidel Corporation Controlled sensitivity immunochromatographic assay
US5710256A (en) * 1995-04-03 1998-01-20 Biosite Diagnostics Incorporated Methadone derivatives and protein and polypeptide methadone derivative conjugates and labels
ZA962939B (en) * 1995-04-12 1997-10-13 Quest Int Oral care compositions.
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5567302A (en) * 1995-06-07 1996-10-22 Molecular Devices Corporation Electrochemical system for rapid detection of biochemical agents that catalyze a redox potential change
US7635597B2 (en) 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
US6803040B1 (en) 1995-08-22 2004-10-12 Biosite, Inc. Derivatives of tricyclic antidepressants and protein and polypeptide tricyclic antidepressant derivative conjugates and labels
US5874216A (en) 1996-02-23 1999-02-23 Ensys Environmental Products, Inc. Indirect label assay device for detecting small molecules and method of use thereof
EP0904066A4 (de) 1996-05-03 2002-04-24 Roger S Cubicciotti Prodrug-zusammensetzungen und verfahren zur arzneistoffverabreichung unter verwendung synthetischer rezeptoren
US5879951A (en) 1997-01-29 1999-03-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing unidirectional flow
US20050101032A1 (en) * 1997-02-10 2005-05-12 Metrika, Inc. Assay device, composition, and method of optimizing assay sensitivity
US5939252A (en) 1997-05-09 1999-08-17 Lennon; Donald J. Detachable-element assay device
DE69831229T2 (de) * 1997-05-14 2006-04-13 Biosite Diagnostics Inc., San Diego Schnelle bestimmung des verhältnisses von biologischen molekülen
GB2326712B (en) * 1997-06-25 2001-09-26 Fujirebio Kk Colour devoloping method,enzyme immunoassay using the colour developing method,and immunochromatography incorporating the enzyme immunoassay
US5985675A (en) 1997-12-31 1999-11-16 Charm Sciences, Inc. Test device for detection of an analyte
DE69840657D1 (de) 1997-07-16 2009-04-23 Charm Sciences Inc Verfahren zum Nachweis eines Restanalyts in einer Probe
BE1012049A6 (fr) * 1998-06-25 2000-04-04 Ucb Bioproducts Procede pour la determination d'antibiotique a noyau beta-lactame dans un liquide biologique.
US6392894B1 (en) 1998-01-05 2002-05-21 Biosite Incorporated Media carrier for an assay device
US6194222B1 (en) 1998-01-05 2001-02-27 Biosite Diagnostics, Inc. Methods for monitoring the status of assays and immunoassays
US6830731B1 (en) * 1998-01-05 2004-12-14 Biosite, Inc. Immunoassay fluorometer
US7713703B1 (en) 2000-11-13 2010-05-11 Biosite, Inc. Methods for monitoring the status of assays and immunoassays
US6284194B1 (en) 1998-03-11 2001-09-04 Albert E. Chu Analytical assay device and methods using surfactant treated membranes to increase assay sensitivity
SE9801563D0 (sv) * 1998-04-30 1998-04-30 Pharmacia & Upjohn Diag Ab Förfarande med separation och kit att användas vid förfarandet
AU2003200222B2 (en) * 1998-04-30 2006-02-02 Maiia Ab Ligand binding assay and kit with a separation zone for disturbing analytes
US20060019404A1 (en) * 1998-05-06 2006-01-26 Blatt Joel M Quantitative assay with extended dynamic range
AU8662598A (en) 1998-07-22 2000-02-14 Syntron Bioresearch, Inc. Multiple analyte assay device
WO2000023478A1 (en) * 1998-10-16 2000-04-27 Amersham Pharmacia Biotech Ab Squaric acid activated carrier usable for immobilisation of compounds containing amine groups
CA2254223A1 (en) 1998-11-16 2000-05-16 Biophys, Inc. Device and method for analyzing a biologic sample
US7297554B2 (en) * 1998-11-18 2007-11-20 Microdiagnostics, Inc. Immunoassay system
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US6528323B1 (en) * 1999-06-14 2003-03-04 Praxsys Biosystems, Inc. Bidirectional lateral flow test strip and method
US6727073B1 (en) 1999-11-19 2004-04-27 Binax, Inc. Method for detecting enteric disease
DE10009503A1 (de) * 2000-02-29 2001-08-30 Roche Diagnostics Gmbh Verfahren zur Immobilisierung von Konjugaten in diagnostischen Tests
EP1294749A2 (de) * 2000-03-09 2003-03-26 Heska Corporation Rekombinanten antigenen zur bestimmung des immun-zustandes eines tieres
US6699722B2 (en) 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
AU2001282035B2 (en) * 2000-08-03 2006-11-09 Inverness Medical Switzerland Gmbh Peptides capable of functioning as mimotopes for estradiol analytes
EP1947459A3 (de) * 2000-08-24 2008-09-24 Nanogen, Inc. Differential-Immunoassay
US6777198B2 (en) 2000-10-11 2004-08-17 Pharmacia Diagnostics Ab Assay method and kit therefor
SE0003662D0 (sv) * 2000-10-11 2000-10-11 Pharmacia Diagnostics Ab Assay method and kit therefor
ES2390425T3 (es) 2000-12-22 2012-11-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uso de moléculas de orientación repulsivas (RGM) y sus moduladores
US6770434B2 (en) 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
US6767710B2 (en) * 2001-03-30 2004-07-27 Praxsys Biosystems, Llc Prewetting stop flow test strip
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US6833111B2 (en) 2001-04-13 2004-12-21 Varian, Inc. Multiple analyte assaying device with a multiple sample introduction system
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
WO2003016910A1 (en) * 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7632647B2 (en) * 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
DE60235416D1 (de) * 2001-05-04 2010-04-01 Biosite Inc Diagnostische Marker der akuten koronaren Syndrome und ihre Verwendungen
DE10125258A1 (de) * 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
US7605004B2 (en) * 2001-07-18 2009-10-20 Relia Diagnostic Systems Llc Test strip for a lateral flow assay for a sample containing whole cells
US7300633B2 (en) 2001-07-25 2007-11-27 Oakville Hong Kong Company Limited Specimen collection container
US7270959B2 (en) 2001-07-25 2007-09-18 Oakville Hong Kong Company Limited Specimen collection container
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7858321B2 (en) * 2001-09-10 2010-12-28 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
US7393696B2 (en) * 2001-09-28 2008-07-01 Aspenbio Pharma, Inc. Bovine pregnancy test
US8481334B1 (en) 2001-11-06 2013-07-09 Charm Sciences, Inc. Method of attaching a ligand to a solid support
JP4667874B2 (ja) * 2002-12-26 2011-04-13 メソ スケール テクノロジーズ エルエルシー バイオマーカーを抽出するための方法、組成物およびキット
US7560272B2 (en) 2003-01-04 2009-07-14 Inverness Medical Switzerland Gmbh Specimen collection and assay container
ES2535045T3 (es) 2003-04-10 2015-05-04 Vanderbilt Royalty Sub L.P. Usos y composiciones para administración de capsaicina
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
CN100360938C (zh) * 2003-04-23 2008-01-09 北京科美东雅生物技术有限公司 甾体类激素-碱性磷酸酶结合物制备方法
US7517495B2 (en) 2003-08-25 2009-04-14 Inverness Medical Switzerland Gmbh Biological specimen collection and analysis system
CA2537668A1 (en) * 2003-09-29 2005-04-14 Biosite Incorporated Methods and compositions for the diagnosis of sepsis
US7410808B1 (en) * 2003-12-08 2008-08-12 Charm Sciences, Inc. Method and assay for detection of residues
US7150995B2 (en) * 2004-01-16 2006-12-19 Metrika, Inc. Methods and systems for point of care bodily fluid analysis
US20050227370A1 (en) * 2004-03-08 2005-10-13 Ramel Urs A Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays
ATE479096T1 (de) * 2004-07-29 2010-09-15 Relia Diagnostic Systems Llc Querstromsystem und assay
US20060105419A1 (en) * 2004-08-16 2006-05-18 Biosite, Inc. Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
EP1794588A2 (de) * 2004-09-09 2007-06-13 Biosite Incorporated Verfahren und zusammensetzungen zur messung von hunde-bnp und verwendungen davon
US20060205012A1 (en) * 2004-12-09 2006-09-14 Meso Scale Technologies, Llc Diagnostic test
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
WO2006078813A2 (en) * 2005-01-21 2006-07-27 Biosite Incorporated Arginine analogs, and methods for their synthesis and use
US7396689B2 (en) * 2005-02-04 2008-07-08 Decision Biomarkers Incorporated Method of adjusting the working range of a multi-analyte assay
CN101189000A (zh) * 2005-02-14 2008-05-28 纽罗吉斯克斯公司 Trpv1激动剂的递送装置
WO2006105481A1 (en) * 2005-03-30 2006-10-05 Neurogesx, Inc. Low-concentration capsaicin patch and methods for treating neuropathic pain
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US7393919B2 (en) 2005-05-25 2008-07-01 Cure Dm, Inc. Peptides, derivatives and analogs thereof, and methods of using same
CA2610875A1 (en) 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
CA2610910A1 (en) * 2005-06-09 2006-12-21 Paul H. Mcpherson Methods and compositions for the diagnosis of venous thromboembolic disease
WO2007028070A2 (en) * 2005-08-30 2007-03-08 Biosite, Inc. Use of soluble flt-1 and its fragments in cardiovascular conditions
US7829347B2 (en) * 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
US8906864B2 (en) 2005-09-30 2014-12-09 AbbVie Deutschland GmbH & Co. KG Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US20070224643A1 (en) * 2006-03-09 2007-09-27 Mcpherson Paul H Methods and compositions for the diagnosis of diseases of the aorta
US8940527B2 (en) * 2006-03-31 2015-01-27 Lamina Equities Corp. Integrated device for analyte testing, confirmation, and donor identity verification
US7879623B2 (en) * 2006-03-31 2011-02-01 Guirguis Raouf A Integrated device for analyte, testing, confirmation, and donor identity verification
US7741103B2 (en) * 2006-03-31 2010-06-22 Guirguis Raouf A Integrated screening and confirmation device
US11906512B2 (en) 2006-03-31 2024-02-20 Zeus Diagnostics, LLC Integrated device for analyte testing, confirmation, and donor identity verification
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
WO2007142540A1 (en) 2006-06-07 2007-12-13 Otago Innovation Limited Diagnostic methods and markers
US20100311186A1 (en) * 2006-07-28 2010-12-09 Biosite Incorporated Devices and methods for performing receptor binding assays using magnetic particles
ES2655564T3 (es) 2006-09-07 2018-02-20 Otago Innovation Limited Biomarcador para la detección precoz de trastornos cardiacos agudos
EP2095106B1 (de) * 2006-11-14 2013-03-20 Alere San Diego, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenarterienstenose
EP2095107B1 (de) 2006-11-14 2014-07-02 Alere San Diego, Inc. Verfahren zur risikoabschätzung
US20080112847A1 (en) * 2006-11-15 2008-05-15 Nancy Yu Chen Collecting and testing device and method of use
TW200826088A (en) * 2006-12-08 2008-06-16 Lite On It Corp Optical disk drive with defocus-prohibited device
EP1933140B1 (de) * 2006-12-11 2011-08-17 AraGen Biotechnology Co. Ltd. Verfahren zur Detektion von Antikörpern mittels eines durch Oligonukleotide verstärkten kolloidalen Gold Signals
CN101021526B (zh) 2007-03-16 2012-01-25 艾博生物医药(杭州)有限公司 一种直观显示检测结果的装置和方法
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
EP2201374B1 (de) 2007-08-30 2015-10-07 Trustees Of Tufts College Verfahren zur bestimmung der konzentration eines analyten in lösung
NZ599756A (en) 2007-08-30 2013-09-27 Curedm Group Holdings Llc Compositions and methods of using proislet peptides and analogs thereof
WO2009032117A2 (en) * 2007-08-31 2009-03-12 Corning Incorporated Reactive surface on a polymeric substrate
US20110082080A1 (en) * 2007-10-12 2011-04-07 Curedm Group Holdings, Llc Compositions and methods of using the human proislet peptide receptor
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
AU2009224114B2 (en) 2008-03-12 2013-02-21 Otago Innovation Limited Biomarkers
CA2715914C (en) 2008-03-12 2019-01-22 Otago Innovation Limited Insulin signal peptide fragment biomarkers
NZ610356A (en) 2008-08-28 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2010025434A1 (en) 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
CN104399089B (zh) 2008-10-21 2017-04-19 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
EP2767833A3 (de) 2008-10-21 2014-12-17 Astute Medical, Inc. Verfahren und Zusammensetzungen zur Diagnose und Prognose von Nierenläsion und Niereninsuffizienz
NZ592488A (en) 2008-11-10 2012-10-26 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104034901A (zh) 2008-11-22 2014-09-10 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
EP2194381B1 (de) 2008-12-03 2015-12-02 Roche Diagnostics GmbH Testelement mit kombinierter Kontroll- und Kalibrationszone
WO2010065944A1 (en) * 2008-12-05 2010-06-10 Serametrix Autoantibody detection systems and methods
US9234889B1 (en) 2008-12-18 2016-01-12 Charm Sciences, Inc. Method and test strip for detecting residues
WO2010091236A1 (en) 2009-02-06 2010-08-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and failure
CN105675881A (zh) 2009-02-06 2016-06-15 阿斯图特医药公司 肾损伤和肾衰竭的诊断及预后
WO2010120917A2 (en) * 2009-04-15 2010-10-21 Relia Diagnostic Systems, Inc. Expanding the dynamic range of a test strip
JP5728005B2 (ja) * 2009-06-30 2015-06-03 コーニンクレッカ フィリップス エヌ ヴェ 磁気センサ装置、このような装置の作動方法及びサンプル
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
AU2010279302B2 (en) 2009-08-07 2015-06-18 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ598034A (en) 2009-08-07 2014-06-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102792161B (zh) 2009-08-28 2014-11-12 阿斯图特医药公司 肾损伤和肾衰竭的诊断及预后的方法及组合物
WO2011035097A1 (en) 2009-09-18 2011-03-24 Astute Medical, Inc. Methods and composition for diagnosis and prognosis of renal injury and renal failure
WO2011035323A1 (en) 2009-09-21 2011-03-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3153863B1 (de) 2009-11-07 2020-04-01 Astute Medical, Inc. Verfahren und verwendungen zur bewertung von akutem nierenversagen/akuter nierenschädigung
WO2011057147A1 (en) 2009-11-07 2011-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
SG181563A1 (en) 2009-12-08 2012-07-30 Abbott Gmbh & Co Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
MX342967B (es) 2009-12-20 2016-10-19 Astute Medical Inc Metodos y composiciones para la diagnosis y prognosis de lesion renal y falla renal.
US11275084B2 (en) 2010-01-15 2022-03-15 Stanford University Successive sampling device and associated method
CA2789147A1 (en) 2010-02-05 2011-08-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2013519095A (ja) 2010-02-05 2013-05-23 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
AU2011213686B2 (en) 2010-02-05 2015-11-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR20140051754A (ko) 2010-02-26 2014-05-02 아스튜트 메디컬 인코포레이티드 신장 손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물
WO2012048082A2 (en) 2010-10-07 2012-04-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2542890B1 (de) 2010-03-01 2015-05-06 Quanterix Corporation Verfahren zur erweiterung des dynamischen bereichs bei tests für den nachweis von molekülen oder partikeln
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
ES2945032T3 (es) 2010-05-06 2023-06-28 Charm Sciences Inc Dispositivo de incubadora con lector
EP2585826A4 (de) 2010-06-23 2013-12-04 Astute Medical Inc Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
WO2011162821A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ703055A (en) 2010-06-23 2016-07-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3246335A3 (de) 2010-07-19 2017-12-27 Otago Innovation Limited Signalbiomarker
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
JP2013541005A (ja) 2010-09-24 2013-11-07 アスチュート メディカル，インコーポレイテッド ヒアルロン酸を使用した腎損傷の評価のための方法ならびに組成物
US10557856B2 (en) 2010-09-24 2020-02-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biomarkers of renal injury
EP2646822B1 (de) 2010-11-29 2017-11-01 Alere San Diego, Inc. Verfahren zur diagnose und risikovorhersage bei herzversagen
CN102121901B (zh) * 2010-11-30 2012-07-04 南通市伊士生物技术有限责任公司 一种金标试条半定量快速检测电子笔装置的检测方法
CN102095851A (zh) * 2010-11-30 2011-06-15 南通市伊士生物技术有限责任公司 金标试条半定量快速检测电子笔装置的检测方法
JP6056138B2 (ja) * 2010-12-28 2017-01-11 東ソー株式会社 免疫学的測定方法
EP2661626B1 (de) 2011-01-08 2016-06-01 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
US9551720B2 (en) 2011-01-26 2017-01-24 University of Pittsburgh—Of the Commonwaelth System of Higher Education Urine biomarkers for prediction of recovery after acute kidney injury: proteomics
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2668499A4 (de) 2011-01-29 2015-05-27 Astute Medical Inc Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
WO2012129650A1 (en) * 2011-03-25 2012-10-04 Nanospeed Diagnostics Inc. Lateral flow immunoassay for detecting vitamins
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
US9459261B2 (en) 2011-08-26 2016-10-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2012340748A1 (en) 2011-11-22 2014-06-26 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US10935548B2 (en) 2011-12-08 2021-03-02 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2
CA2855570A1 (en) 2011-12-14 2013-06-20 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
US10118958B2 (en) 2011-12-14 2018-11-06 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
MY176695A (en) 2012-01-27 2020-08-19 Abbvie Inc Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration
CA2865563A1 (en) 2012-02-27 2013-09-06 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR20140147837A (ko) 2012-03-13 2014-12-30 애브비 인코포레이티드 Ｖ1ｂ 길항제 치료요법을 위한 대상체를 선택하거나 선별하는 방법
DK2828282T3 (en) 2012-03-20 2018-03-05 Otago Innovation Ltd Biomarkers
US20150293131A1 (en) 2012-04-02 2015-10-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
CN104204800A (zh) 2012-04-11 2014-12-10 美艾利尔圣地亚哥公司 微流体装置、系统和方法
CN104364652A (zh) * 2012-04-20 2015-02-18 Zbx公司 用于检测样品中的分析物的固相载体和方法
EP2841945A4 (de) 2012-04-24 2016-04-27 Astute Medical Inc Verfahren und zusammensetzungen zur diagnose und prognose von schlaganfall oder anderen hirnläsionen
DE202012012084U1 (de) 2012-07-09 2013-04-15 Schebo Biotech Ag Testkit (Kombi-Schnelltest) zum synchronen Nachweis von Biomarkern im Stuhl zur Erkennung pathologischer Veränderungen im Gastrointestinaltrakt, insbesondere im Darm
DE102012013888A1 (de) 2012-07-09 2014-05-22 Schebo Biotech Ag Testkit (Kombi-Schnelltest) zum synchronen Nachweis von Biomarkern im Stuhl zur Erkennung pathologischer Veränderungen im Gastrointestinaltrakt, insbesondere im Darm
US20150177260A1 (en) 2012-07-23 2015-06-25 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
US20150241415A1 (en) 2012-08-11 2015-08-27 Astute Medical, Inc. Evaluating renal injury using hyaluronic acid
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
AU2014207509B2 (en) 2013-01-17 2019-12-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2014152657A1 (en) 2013-03-14 2014-09-25 Alere San Diego, Inc. 6-acetylmorphine analogs, and methods for their synthesis and use
PE20151873A1 (es) 2013-03-14 2016-01-06 Kasing Cheng Sistema de carcasa de tira de prueba
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
WO2014197729A1 (en) 2013-06-05 2014-12-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2753419T3 (es) 2013-06-07 2020-04-08 Univ Duke Inhibidores del factor H del complemento
CA2920521A1 (en) 2013-08-07 2015-02-12 Astute Medical, Inc. Assays for timp2 having improved performance in biological samples
TWI717026B (zh) 2013-08-23 2021-01-21 美商瑞塔醫藥有限責任公司 使用齊墩果酸(bardoxolone methyl)或其類似物治療和預防內皮功能障礙之方法
WO2015031626A1 (en) 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
WO2015179773A1 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
EP3693738A1 (de) 2013-09-20 2020-08-12 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von appendizitis und differenzierung von ursachen für bauchschmerzen
CN105793439B (zh) 2013-11-06 2020-09-04 阿斯图特医药公司 以生物样品进行的针对igfbp7的具有改进的性能的测定
CN105917229B (zh) 2013-12-03 2019-04-26 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
US10711311B2 (en) 2013-12-30 2020-07-14 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Genomic rearrangements associated with prostate cancer and methods of using the same
EP3146076A4 (de) 2014-05-22 2018-05-09 The Scripps Research Institute Mit subklinischer nierentransplantatabstossung assoziierte genexpressionsprofile
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
CA2949959A1 (en) 2014-05-22 2015-11-26 Northwestern University Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
KR102431003B1 (ko) 2014-10-20 2022-08-09 아스튜트 메디컬 인코포레이티드 신손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물
WO2016090244A2 (en) 2014-12-05 2016-06-09 Mbio Diagnostics, Inc. Methods and devices for performing high dynamic range immunoassays
EP3233106B1 (de) 2014-12-18 2023-02-01 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
WO2016164854A1 (en) 2015-04-09 2016-10-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2018521307A (ja) 2015-05-12 2018-08-02 アスチュート メディカル，インコーポレイテッド 腎障害および腎不全の診断および予後のための方法および組成物
CA2988980A1 (en) 2015-06-11 2016-12-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20180224466A1 (en) 2015-06-17 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
AU2016291558A1 (en) 2015-07-10 2018-02-08 West Virginia University Markers of stroke and stroke severity
CA3001918C (en) 2015-10-15 2023-08-22 Inbios International, Inc. Multiplexed lateral flow assay systems and methods for their use
EP3420364A4 (de) * 2016-02-24 2019-10-09 Emanuel Smeds Verfahren zur verwendung von biologischem material zur bestimmung der unterschiede in der bindung an ein moleküle von interesse
EP3458439B1 (de) 2016-05-18 2021-12-08 Alere San Diego, Inc. 2-ethyliden-1,5-dimethyl-3,3-diphenylpyrrolidin-analoga sowie methoden zu deren synthese und verwendung
EP3465201A4 (de) 2016-06-06 2020-08-26 Astute Medical, Inc. Verwaltung von akuter nierenverletzung mit insulinähnlichem wachstumsfaktorbindendem protein 7 und gewebehemmer der metalloproteinase 2
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
EP3519824A1 (de) 2016-10-03 2019-08-07 Abbott Laboratories Verbesserte verfahren zur beurteilung des uch-l1-status in patientenproben
WO2018067730A1 (en) 2016-10-04 2018-04-12 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid a (asla) based therapeutics
CA3042123A1 (en) 2016-11-08 2018-05-17 Reata Pharmaceuticals, Inc. Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
JP6795951B2 (ja) * 2016-11-09 2020-12-02 旭化成株式会社 濃度推定方法、検出装置、処理装置、プログラムおよび検出システム
US11353465B2 (en) 2017-01-12 2022-06-07 Astute Medical, Inc. Methods and compositions for evaluation and treatment of renal injury and renal failure based on C—C motif chemokine ligand 14 measurement
US10564155B2 (en) 2017-01-27 2020-02-18 Raouf A Guirguis Dual swab fluid sample collection for split sample testing and fingerprint identification device
US20200041492A1 (en) 2017-03-09 2020-02-06 Rijksuniversiteit Groningen Biomarkers for cellular senescence
US11016092B2 (en) 2017-03-23 2021-05-25 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase L1
US10877048B2 (en) 2017-04-15 2020-12-29 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
US10877038B2 (en) 2017-04-28 2020-12-29 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
JP2020519904A (ja) 2017-05-07 2020-07-02 アスチュート メディカル，インコーポレイテッド 腎代替療法の管理におけるインスリン様増殖因子結合タンパク質７および組織メタロプロテアーゼ阻害物質２の使用
AU2018272054A1 (en) 2017-05-25 2019-09-26 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
JP7269183B2 (ja) 2017-05-30 2023-05-08 アボット・ラボラトリーズ 心臓トロポニンｉを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法
WO2019010131A1 (en) 2017-07-03 2019-01-10 Abbott Laboratories IMPROVED METHODS FOR MEASURING CARBOXY TERMINATION HYDROLASE LEVELS OF UBIQUITIN L1 IN BLOOD
BR112020010085A2 (pt) 2017-12-09 2020-10-13 Abbott Laboratories métodos para auxiliar no diagnóstico e avaliar uma lesão cerebral traumática em um indivíduo humano usando uma combinação de gfap e uch-l1
US11022617B2 (en) 2017-12-09 2021-06-01 Abbott Laboratories Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using glial fibrillary acidic protein (GFAP) and/or ubiquitin carboxy-terminal hydrolase L1 (UCH-L1)
US11891439B2 (en) 2017-12-28 2024-02-06 Astute Medical, Inc. Antibodies and assays for CCL14
JP7437303B2 (ja) 2017-12-29 2024-02-22 アボット・ラボラトリーズ 外傷性脳損傷を診断及び査定するための、新規のバイオマーカー及び方法
WO2019213619A1 (en) 2018-05-04 2019-11-07 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
EP3846797A4 (de) 2018-09-04 2022-06-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Verwendung von delta-tocotrienol zur behandlung von krebs
US20200209250A1 (en) 2018-12-28 2020-07-02 Abbott Laboratories Direct detection of single molecules on microparticles
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
EP3931573A1 (de) 2019-03-01 2022-01-05 Abbott Laboratories Verfahren zur vorhersage von schwerwiegenden kardiovaskulären ereignissen bei patienten mit koronararterienerkrankung
JP2022522480A (ja) 2019-03-01 2022-04-19 メソ スケール テクノロジーズ エルエルシー 免疫測定法で使用するための電気化学発光標識プローブ、当該プローブを使用する方法および該プローブを含むキット
WO2021211331A1 (en) 2020-04-13 2021-10-21 Abbott Point Of Care Inc. METHODS, COMPLEXES AND KITS FOR DETECTING OR DETERMINING AN AMOUNT OF A ß-CORONAVIRUS ANTIBODY IN A SAMPLE
WO2021222832A1 (en) 2020-05-01 2021-11-04 Meso Scale Technologies, Llc. Viral serology ace2 competition assays
AU2021273460A1 (en) 2020-05-09 2022-12-08 Reata Pharmaceuticals Holdings, LLC Methods of treating covid-19 using bardoxolone methyl or analogs thereof
MX2022015287A (es) 2020-06-01 2023-02-22 Loop Diagnostics S L Metodo y kit para la deteccion temprana de septicemia.
US20220043000A1 (en) 2020-08-04 2022-02-10 Abbott Laboratories Methods and kits for detecting sars-cov-2 protein in a sample
US20220043003A1 (en) 2020-08-04 2022-02-10 Abbott Rapid Diagnostics International Unlimited Company Assays for detecting sars-cov-2
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
CA3198161A1 (en) 2020-12-01 2022-06-09 Beth MCQUISTON Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
EP4259155A1 (de) 2020-12-11 2023-10-18 Reata Pharmaceuticals Holdings, LLC Synthetische triterpenoide zur verwendung in der therapie
WO2022147147A1 (en) 2020-12-30 2022-07-07 Abbott Laboratories Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
AU2022279156A1 (en) 2021-05-18 2023-11-02 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
WO2022246213A1 (en) 2021-05-21 2022-11-24 Meso Scale Techologies, Llc. Assays for viral strain determination
CA3222291A1 (en) 2021-06-14 2022-12-22 Jaime MARINO Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
AU2022304570A1 (en) 2021-06-28 2024-01-18 Meso Scale Technologies, Llc. Methods, compositions, and kits for assay signal amplification
WO2023028186A1 (en) 2021-08-27 2023-03-02 Abbott Laboratories Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample
WO2023034777A1 (en) 2021-08-31 2023-03-09 Abbott Laboratories Methods and systems of diagnosing brain injury
AU2022354059A1 (en) 2021-09-30 2024-03-28 Abbott Laboratories Methods and systems of diagnosing brain injury
WO2023114978A1 (en) 2021-12-17 2023-06-22 Abbott Laboratories Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples
WO2023129942A1 (en) 2021-12-28 2023-07-06 Abbott Laboratories Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023150652A1 (en) 2022-02-04 2023-08-10 Abbott Laboratories Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
WO2023212294A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Angiopoietin-related protein 7-specific antibodies and uses thereof
WO2023212293A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Complement factor h related 4-specific antibodies and uses thereof
WO2023212298A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Bispecific antibodies and methods of treating ocular disease
WO2023245184A1 (en) 2022-06-17 2023-12-21 Meso Scale Technologies, Llc. Viral strain serology assays
WO2024059692A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2024059708A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Biomarkers and methods for differentiating between mild and supermild traumatic brain injury
WO2024064904A1 (en) 2022-09-23 2024-03-28 Meso Scale Technologies, Llc. Orthopoxvirus serology assays

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
US4203802A (en) * 1971-05-14 1980-05-20 Syva Company Inhibitable enzyme amplification assay
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3884898A (en) * 1972-08-18 1975-05-20 Syva Co Normorphine derivatives bonded to proteins
US3878187A (en) * 1972-09-11 1975-04-15 Syva Co Polypeptide derivatives of amphetamine and analogs for immunoassays
SE388694B (sv) * 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
JPS51114985A (en) * 1975-04-01 1976-10-09 Kyoto Daiichi Kagaku:Kk Mothod to analyse urine, etc.
US4120945A (en) * 1976-07-06 1978-10-17 Becton, Dickinson & Company Substrate coated with receptor and labeled ligand for assays
US4200690A (en) * 1976-12-16 1980-04-29 Millipore Corporation Immunoassay with membrane immobilized antibody
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4791055A (en) * 1978-04-10 1988-12-13 Miles Inc. Homogenous specific binding assay reagent system and labeled conjugates
JPS5510590A (en) * 1978-05-04 1980-01-25 Wellcome Found Enzyme immunity quantity analysis
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4246339A (en) * 1978-11-01 1981-01-20 Millipore Corporation Test device
US4281065A (en) * 1979-01-25 1981-07-28 Syva Company Phencyclidine conjugates to antigenic proteins and enzymes
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4533629A (en) * 1981-04-17 1985-08-06 Syva Company Simultaneous calibration heterogeneous immunoassay
US4540659A (en) * 1981-04-17 1985-09-10 Syva Company Simultaneous calibration heterogeneous immunoassay
US4391904A (en) * 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4425438A (en) * 1981-03-13 1984-01-10 Bauman David S Assay method and device
US4446232A (en) * 1981-10-13 1984-05-01 Liotta Lance A Enzyme immunoassay with two-zoned device having bound antigens
WO1983003306A1 (en) * 1982-03-19 1983-09-29 Roger Philip Ekins Method and composition for free ligand assays
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
US4435504A (en) * 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4477576A (en) * 1982-07-26 1984-10-16 Mex Research Associates Antigen assay method and kit
EP0114614A2 (de) * 1983-01-25 1984-08-01 Abbott Laboratories Bestimmung von Steroidhormon-Glucuroniden
US4496654A (en) * 1983-04-08 1985-01-29 Quidel Detection of HCG with solid phase support having avidin coating
GB8331514D0 (en) * 1983-11-25 1984-01-04 Janssen Pharmaceutica Nv Visualization method
US4703017C1 (en) * 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
GB2161165A (en) * 1984-06-12 1986-01-08 Cambridge Patent Dev Secondary antibodies
AU560779B2 (en) * 1985-01-24 1987-04-16 Quidel Assay for drugs of abuse
US4740468A (en) * 1985-02-14 1988-04-26 Syntex (U.S.A.) Inc. Concentrating immunochemical test device and method
GB2171999A (en) * 1985-03-04 1986-09-10 Iq Antibodies
CA1272127A (en) * 1985-04-04 1990-07-31 Hybritech Incorporated Solid phase system for use in ligand-receptor assays
JPS62502495A (ja) * 1985-04-10 1987-09-24 イムニコン・コ−ポレ−ション 直接均質検定
US4743542A (en) * 1985-04-11 1988-05-10 Ortho Diagnostic Method for forestalling the hook effect in a multi-ligand immunoassay system
US4803170A (en) * 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US4746631A (en) * 1985-05-09 1988-05-24 Ultra Diagnostics Corporation Immunoassay method, device, and test kit
JPS62231168A (ja) * 1986-03-21 1987-10-09 ハイブリテツク・インコ−ポレイテツド アナライト−レセプタ−分析用内部標準を設けるための改良法
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US5030558A (en) * 1986-11-07 1991-07-09 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
EP0271204A3 (de) * 1986-11-07 1989-10-25 Syntex (U.S.A.) Inc. Immunochromatographische Methode und Vorrichtung
US4817837A (en) * 1987-09-03 1989-04-04 Grover Betty L Strap for holding skis and ski poles
US4952517A (en) * 1988-02-08 1990-08-28 Hygeia Sciences, Inc. Positive step immunoassay

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JPH03503215A (ja) 1991-07-18
DE69022254T2 (de) 1996-02-15
AU633874B2 (en) 1993-02-11
PT92828A (pt) 1991-09-13
DK0378391T3 (da) 1996-01-02
US5679526A (en) 1997-10-21
GR3018366T3 (en) 1996-03-31
EP0378391A2 (de) 1990-07-18
EP0378391A3 (de) 1991-10-02
PT92828B (pt) 1996-04-30
CA2007532A1 (en) 1990-07-10
US5028535A (en) 1991-07-02
CA2007532C (en) 2002-10-01
EP0378391B1 (de) 1995-09-13
ATE127921T1 (de) 1995-09-15
JP2807565B2 (ja) 1998-10-08
WO1990008319A1 (en) 1990-07-26
AU5021590A (en) 1990-08-13
US5089391A (en) 1992-02-18

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