DE69012587T2 - Verfahren und vorrichtung zur gepulsten iontophoretischen verabreichung von arzneimitteln. - Google Patents

Verfahren und vorrichtung zur gepulsten iontophoretischen verabreichung von arzneimitteln.

Info

Publication number
DE69012587T2
DE69012587T2 DE69012587T DE69012587T DE69012587T2 DE 69012587 T2 DE69012587 T2 DE 69012587T2 DE 69012587 T DE69012587 T DE 69012587T DE 69012587 T DE69012587 T DE 69012587T DE 69012587 T2 DE69012587 T2 DE 69012587T2
Authority
DE
Germany
Prior art keywords
pulse
segment
therapeutic
medicinal products
dual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69012587T
Other languages
English (en)
Other versions
DE69012587D1 (de
Inventor
Larry Mcnichols
Gary Lattin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE69012587D1 publication Critical patent/DE69012587D1/de
Application granted granted Critical
Publication of DE69012587T2 publication Critical patent/DE69012587T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Magnetic Treatment Devices (AREA)
  • Medicinal Preparation (AREA)
DE69012587T 1989-12-22 1990-12-19 Verfahren und vorrichtung zur gepulsten iontophoretischen verabreichung von arzneimitteln. Expired - Lifetime DE69012587T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/456,013 US5047007A (en) 1989-12-22 1989-12-22 Method and apparatus for pulsed iontophoretic drug delivery
PCT/US1990/007551 WO1991009645A1 (en) 1989-12-22 1990-12-19 Method and apparatus for pulsed iontophoretic drug delivery

Publications (2)

Publication Number Publication Date
DE69012587D1 DE69012587D1 (de) 1994-10-20
DE69012587T2 true DE69012587T2 (de) 1995-01-12

Family

ID=23811093

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69012587T Expired - Lifetime DE69012587T2 (de) 1989-12-22 1990-12-19 Verfahren und vorrichtung zur gepulsten iontophoretischen verabreichung von arzneimitteln.

Country Status (14)

Country Link
US (1) US5047007A (de)
EP (1) EP0506879B1 (de)
JP (1) JP3180129B2 (de)
KR (1) KR0154112B1 (de)
AT (1) ATE111367T1 (de)
AU (1) AU637674B2 (de)
CA (1) CA2069750C (de)
DE (1) DE69012587T2 (de)
DK (1) DK0506879T3 (de)
ES (1) ES2064084T3 (de)
FI (1) FI110309B (de)
GR (1) GR1001071B (de)
NO (1) NO306895B1 (de)
WO (1) WO1991009645A1 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956032B1 (en) 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5961482A (en) * 1986-07-25 1999-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US5547467A (en) * 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
ES2129035T3 (es) * 1989-05-10 1999-06-01 Drug Delivery Systems Inc Aplicador de medicina transdermal electrico de multiples señales.
US4950229A (en) * 1989-09-25 1990-08-21 Becton, Dickinson And Company Apparatus for an electrode used for iontophoresis
US5320597A (en) * 1991-02-08 1994-06-14 Becton, Dickinson And Company Device and method for renewing electrodes during iontophoresis
JP2816886B2 (ja) * 1990-03-05 1998-10-27 興和株式会社 生体通電装置
US5334138A (en) * 1990-03-15 1994-08-02 North Carolina State University Method and composition for increased skin concentration of active agents by iontophoresis
US6139537A (en) * 1990-11-01 2000-10-31 Tapper; Robert Iontophoretic treatment system
US6575957B1 (en) * 1990-11-01 2003-06-10 Robert Tapper Iontophoretic treatment system
US6600950B1 (en) * 1990-11-01 2003-07-29 Robert Tapper Iontophoretic treatment system
US6223076B1 (en) 1990-11-01 2001-04-24 Robert Tapper Sweat control system
US6235013B1 (en) 1990-11-01 2001-05-22 Robert Tapper Iontophoretic treatment system
US6238381B1 (en) 1990-11-01 2001-05-29 Robert Tapper Iontophoretic treatment system
US5224927A (en) * 1990-11-01 1993-07-06 Robert Tapper Iontophoretic treatment system
US6582416B2 (en) 1990-11-01 2003-06-24 Robert Tapper Iontophoretic treatment system
US5431625A (en) * 1991-02-01 1995-07-11 Empi, Inc. Iontophoresis electronic device having a ramped output current
NL9100662A (nl) * 1991-04-17 1992-11-16 Optische Ind De Oude Delft Nv Inrichting voor het uitvoeren van een iontoforese-behandeling bij een patient.
US5158081A (en) * 1991-05-29 1992-10-27 Trillion Medical Resources, Inc. Method for treatment of soft tissue wounds by electrical stimulation
DE4137960A1 (de) * 1991-11-19 1993-05-27 Gerhard Prof Schauf Therapiegeraet zur iontophorese im haut- und schweissdruesenbereich
US5246417A (en) * 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5256137A (en) * 1992-03-10 1993-10-26 Becton Dickinson And Company Biphasic power source for use in an iontophoretic drug delivery system
CA2084734C (en) * 1991-12-17 1998-12-01 John L. Haynes Iontophoresis system having features for reducing skin irritation
FR2687321B1 (fr) * 1992-02-14 1999-04-16 Elf Aquitaine Dispositif d'ionophorese pour l'administration transcutanee d'une quantite totale donnee d'un principe actif a un sujet.
DE4217039C2 (de) * 1992-05-22 1995-07-13 Boehringer Ingelheim Kg Vorrichtung für die iontophoretische Applikation, bei der der Wirkstofffluß maximiert ist, Vorrichtung zur Bestimmung der zugehörigen Frequenz sowie entsprechendes Iontophoreseverfahren
US5282482A (en) * 1992-06-18 1994-02-01 Wilk Peter J Pressure relief support pad
US5380271A (en) * 1992-09-24 1995-01-10 Alza Corporation Electrotransport agent delivery device and method
US5306235A (en) * 1992-09-30 1994-04-26 Becton Dickinson And Company Failsafe iontophoresis drug delivery system
US5634899A (en) * 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5415629A (en) * 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
WO1995009032A1 (en) * 1993-09-30 1995-04-06 Becton, Dickinson And Company Iontophoretic drug delivery system and method
US5387189A (en) * 1993-12-02 1995-02-07 Alza Corporation Electrotransport delivery device and method of making same
JP3549540B2 (ja) * 1994-03-30 2004-08-04 アルザ・コーポレーション 電気的移送式投与中の皮膚刺激状態の軽減
US5540654A (en) * 1994-09-02 1996-07-30 North Carolina State University Iontophoretic electrode
US7027859B1 (en) * 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
US5551953A (en) * 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
US5562607A (en) * 1995-01-18 1996-10-08 Alza Corporation Electrotransport device having reusable controller power saver
US5879322A (en) * 1995-03-24 1999-03-09 Alza Corporation Self-contained transdermal drug delivery device
US5843014A (en) * 1995-03-24 1998-12-01 Alza Corporation Display for an electrotransport delivery device
US5978701A (en) * 1995-06-02 1999-11-02 Alza Corporation Electrotransport device with separable controller and drug unit and method of setting controller output
IE960312A1 (en) * 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
IE960375A1 (en) * 1995-06-05 1996-12-11 Alza Corp Device for transdermal electrotransport delivery of fentanyl¹and sufentanil
CA2218369C (en) 1995-06-05 2010-02-09 Alza Corporation Transdermal electrotransport delivery of fentanyl and sufentanil
US6881208B1 (en) * 1995-06-05 2005-04-19 Joseph B. Phipps Method and device for transdermal electrotransport delivery of fentanyl and sufentanil
US6216033B1 (en) 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6425892B2 (en) 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US5983130A (en) 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US7572252B1 (en) 1995-06-07 2009-08-11 Alza Corporation Electrotransport agent delivery method and apparatus
US6355025B1 (en) 1995-06-07 2002-03-12 Alza Corporation Adjustable electrotransport drug delivery using a fixed output controller
US5983131A (en) * 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US6167301A (en) 1995-08-29 2000-12-26 Flower; Ronald J. Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
US6086572A (en) * 1996-05-31 2000-07-11 Alza Corporation Electrotransport device and method of setting output
US6718201B1 (en) * 1996-06-07 2004-04-06 Alza Corporation Electrotransport agent delivery method and apparatus
US5911223A (en) * 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5869326A (en) * 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
ATE238046T1 (de) * 1996-11-14 2003-05-15 Alza Corp Einrichtung zur verabreichung von substanzen wie lidocain und epinephrin mit unterstuetzung von elektrischem strom
US5935156A (en) * 1997-03-12 1999-08-10 Microleve International, Ltd. Method and apparatus for administering microcurrent electrotherapy treatment
US6085115A (en) * 1997-05-22 2000-07-04 Massachusetts Institite Of Technology Biopotential measurement including electroporation of tissue surface
US6047208A (en) * 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US6295469B1 (en) 1997-11-14 2001-09-25 Alza Corporation Formulation for electrically assisted delivery of lidocaine and epinephrine
JP4262410B2 (ja) * 1998-01-28 2009-05-13 アルザ・コーポレーション 低い初期抵抗を有する電気伝達電極アセンブリ
US5945123A (en) * 1998-04-02 1999-08-31 K-V Pharmaceutical Company Maximizing effectiveness of substances used to improve health and well being
US20040062802A1 (en) * 1998-04-02 2004-04-01 Hermelin Victor M. Maximizing effectiveness of substances used to improve health and well being
DE19845065A1 (de) * 1998-05-15 1999-11-25 Siemens Ag Vorrichtung zur kontaktlosen Übertragung von Daten
US6148231A (en) 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6858018B1 (en) 1998-09-28 2005-02-22 Vyteris, Inc. Iontophoretic devices
CN1170604C (zh) 1998-11-02 2004-10-13 阿尔萨公司 含有可相容的抗菌剂的电转运装置
US6424862B1 (en) 1999-02-10 2002-07-23 Gmp Drug Delivery, Inc. Iontophoresis electroporation and combination patches for local drug delivery to body tissues
US7127285B2 (en) 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6385488B1 (en) 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
AU2001241483A1 (en) 2000-02-18 2001-08-27 University Of Utah Research Foundation Methods for extracting substances using alternating current
US6512950B2 (en) 2000-02-18 2003-01-28 University Of Utah Research Foundation Methods for delivering agents using alternating current
IL154838A0 (en) * 2000-09-11 2003-10-31 Alza Corp Transdermal electrotransport device and method for manufacturing same
US7137975B2 (en) 2001-02-13 2006-11-21 Aciont, Inc. Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
EP1385571B1 (de) * 2001-04-04 2008-07-30 Alza Corporation Transdermales verabreichungsgerät mittels elektrotransport mit einer kompatiblen antimikrobiellen reservoir-lösung
US6770080B2 (en) 2001-04-26 2004-08-03 Fenestra Medical, Inc. Mechanically registered videoscopic myringotomy/tympanostomy tube placement system
ITTO20010534A1 (it) * 2001-06-04 2002-12-04 Igea Srl Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore.
US6810877B2 (en) * 2001-08-02 2004-11-02 Medical Electronics Devices Corp. High sensitivity pressure switch
DE60231148D1 (de) * 2001-12-19 2009-03-26 Alza Corp Reservoir-gehäuse mit einer integrierten leitenden region
DK1455893T3 (da) * 2001-12-20 2007-04-02 Alza Corp Elektrotransportindretning med et integralt stöbt reservoirhus
US6823202B2 (en) * 2002-04-01 2004-11-23 Iomed, Inc. Iontophoretic power supply
US20060009730A2 (en) * 2002-07-29 2006-01-12 Eemso, Inc. Iontophoretic Transdermal Delivery of One or More Therapeutic Agents
CA2500713C (en) * 2002-10-04 2012-07-03 Photokinetix, Inc. Photokinetic delivery of biologically active substances using pulsed incoherent light
TW200416015A (en) * 2003-02-17 2004-09-01 Wei-Gung Wang Device for selectively generating hydrogen ions in an aqueous solution
US8224435B2 (en) * 2003-03-31 2012-07-17 Alza Corporation Electrotransport device having a reservoir housing having a flexible conductive element
MXPA06005509A (es) * 2003-11-13 2007-05-23 Johnson & Johnson Sistema y metodo para distribucion transdermica.
US20050220439A1 (en) * 2004-03-19 2005-10-06 Carton Owen A Interactive multimedia system and method
US20050226921A1 (en) * 2004-04-13 2005-10-13 Kortzebom Robert N Non-invasive analysis and controlled dosage transdermal active patch
UY28935A1 (es) * 2004-06-03 2005-07-29 Alza Corp Sistema y metodo para la administracion transdermica de un anticoagulante
US20090143761A1 (en) * 2005-06-03 2009-06-04 Transdermal Patents Company, Llc Agent delivery system and uses of same
WO2006133102A2 (en) * 2005-06-03 2006-12-14 Trans-Dermal Patents Company, Llc Agent delivery system and uses of the same
JP2007037868A (ja) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc 経皮投与装置及びその制御方法
WO2007026671A1 (ja) * 2005-08-29 2007-03-08 Transcu Ltd. センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
US20070071807A1 (en) * 2005-09-28 2007-03-29 Hidero Akiyama Capsule-type drug-releasing device and capsule-type drug-releasing device system
US20070149916A1 (en) * 2005-12-22 2007-06-28 Alza Corporation Dry matrices as drug reservoirs in electrotransport applications
US20080009782A1 (en) * 2006-06-28 2008-01-10 Alza Corporation Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
KR100730582B1 (ko) * 2006-11-20 2007-06-20 아람휴비스(주) 이온토포레시스 장치
BRPI0719353A2 (pt) * 2006-12-01 2014-01-07 Titi Ellebeau Inc Sistemas, dispositivos e métodos para dispositivos de energização e/ou controle, por exemplo, dispositivos de distribuição transdérmicos
MX2009010000A (es) 2007-03-19 2010-03-17 Insuline Medical Ltd Dispositivo para el suministro de farmaco.
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US8425488B2 (en) 2007-04-19 2013-04-23 Acclarent, Inc. System and method for the simultaneous bilateral treatment of target tissues within the ears using a guide block structure
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
EP2043733A1 (de) 2007-06-26 2009-04-08 Alza Corporation Verfahren und vorrichtungen zur transdermalen elektrotransport-verabreichung von lofentanil und carfentanil
US8192420B2 (en) 2007-12-20 2012-06-05 Acclarent, Inc. Iontophoresis methods
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US8452392B2 (en) 2008-07-31 2013-05-28 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
US8840602B2 (en) * 2008-07-31 2014-09-23 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
US8150525B2 (en) * 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
BRPI0916125A2 (pt) 2008-11-07 2015-11-03 Insuline Medical Ltd "dispositivo de tratamento"
ES2612830T3 (es) * 2008-12-30 2017-05-18 Teva Pharmaceuticals International Gmbh Control electrónico de sistema de administración de fármacos
US9539146B2 (en) 2009-07-15 2017-01-10 Tusker Medical, Inc. Trigger assembly for tympanostomy tube delivery device
US9770366B2 (en) 2009-07-15 2017-09-26 Tusker Medical, Inc. Tympanic membrane pressure equalization tube delivery system
CA2817824A1 (en) 2010-11-23 2012-05-31 Nupathe, Inc. User-activated self-contained co-packaged iontophoretic drug delivery system
US8428709B1 (en) 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
US8428708B1 (en) 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
US8781571B2 (en) 2011-03-31 2014-07-15 Incline Therapeutics, Inc. Switch validation circuit and method
US9731121B2 (en) 2011-03-31 2017-08-15 Incline Therapeutics, Inc. Switch validation circuit and method
EP2694150A1 (de) * 2011-04-08 2014-02-12 Covidien LP Iontophorese-medikamentenabgabesystem sowie verfahren zur denervierung der renalen sympathischen nerven und iontophorese-medikamentenabgabe
CN103826581B (zh) 2011-07-25 2016-05-04 阿克拉伦特公司 用于麻醉鼓膜的个性化系统和方法
US9364648B2 (en) 2012-05-30 2016-06-14 Tusker Medical, Inc. Adhesive earplugs useful for sealing the ear canal
US10130808B2 (en) 2013-03-14 2018-11-20 Tusker Medical, Inc. System and method for providing iontophoresis at tympanic membrane
US9320652B2 (en) 2013-03-14 2016-04-26 Tusker Medical, Inc. Features to improve and sense tympanic membrane apposition by tympanostomy tube delivery instrument
US9681891B2 (en) 2013-03-14 2017-06-20 Tusker Medical, Inc. Tympanostomy tube delivery device with cutting dilator
US20160038341A1 (en) 2014-08-08 2016-02-11 Acclarent, Inc. Tympanostomy tube delivery device with elastomeric brake
US10195086B2 (en) 2014-08-11 2019-02-05 Tusker Medical, Inc. Tympanostomy tube delivery device with rotatable
US9833359B2 (en) 2014-08-12 2017-12-05 Tusker Medical, Inc. Tympanostomy tube delivery device with cutter force clutch
US9833360B2 (en) 2014-08-12 2017-12-05 Tusker Medical, Inc. Tympanostomy tube delivery device with replaceable shaft portion
CA2936741C (en) 2014-10-31 2018-11-06 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10016304B2 (en) 2015-07-16 2018-07-10 Tusker Medical, Inc. Earplug assembly for iontophoresis system
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794910A (en) * 1971-07-26 1974-02-26 Sherwood Medical Ind Inc Iontophoresis and conductivity analysis circuit
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US4019510A (en) * 1975-02-10 1977-04-26 Sybron Corporation Therapeutic method of using low intensity direct current generator with polarity reversal
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
JPS5347192A (en) * 1976-10-13 1978-04-27 Matsushita Electric Ind Co Ltd Device for introducing fluorine ion to tooth
US4340047A (en) * 1978-10-18 1982-07-20 Robert Tapper Iontophoretic treatment apparatus
US4301794A (en) * 1978-10-18 1981-11-24 Robert Tapper Method for iontophoretic treatment
US4292968A (en) * 1979-11-26 1981-10-06 Sybron Corporation Electric supply for ion therapy
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
US4456012A (en) * 1982-02-22 1984-06-26 Medtronic, Inc. Iontophoretic and electrical tissue stimulation device
US4808152A (en) * 1983-08-18 1989-02-28 Drug Delivery Systems Inc. System and method for controlling rate of electrokinetic delivery of a drug
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US4846950A (en) * 1983-09-08 1989-07-11 Montefiore Hospital Assn Of Western Pa Cyclic controlled electrolysis apparatus
US4543956A (en) * 1984-05-24 1985-10-01 Cordis Corporation Biphasic cardiac pacer
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
AU615188B2 (en) * 1987-05-28 1991-09-26 Drug Delivery Systems Inc. Pulsating transdermal drug delivery system
JPS6456060A (en) * 1987-08-27 1989-03-02 Hayashibara Takeshi Low frequency medical treatment device

Also Published As

Publication number Publication date
ATE111367T1 (de) 1994-09-15
EP0506879B1 (de) 1994-09-14
DE69012587D1 (de) 1994-10-20
WO1991009645A1 (en) 1991-07-11
AU7148091A (en) 1991-07-24
CA2069750C (en) 2001-04-10
EP0506879A1 (de) 1992-10-07
AU637674B2 (en) 1993-06-03
FI922830A (fi) 1992-06-17
NO922441L (no) 1992-08-19
KR920703147A (ko) 1992-12-17
DK0506879T3 (da) 1995-02-13
GR1001071B (el) 1993-04-28
JPH05504703A (ja) 1993-07-22
ES2064084T3 (es) 1995-01-16
CA2069750A1 (en) 1991-06-23
NO306895B1 (no) 2000-01-10
GR900100877A (en) 1992-05-12
KR0154112B1 (ko) 1998-11-16
JP3180129B2 (ja) 2001-06-25
US5047007A (en) 1991-09-10
NO922441D0 (no) 1992-06-19
FI922830A0 (fi) 1992-06-17
FI110309B (fi) 2002-12-31

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