DE68919900T2 - Vernetzte Karboxylgruppe enthaltende Polysaccharide. - Google Patents

Vernetzte Karboxylgruppe enthaltende Polysaccharide.

Info

Publication number
DE68919900T2
DE68919900T2 DE68919900T DE68919900T DE68919900T2 DE 68919900 T2 DE68919900 T2 DE 68919900T2 DE 68919900 T DE68919900 T DE 68919900T DE 68919900 T DE68919900 T DE 68919900T DE 68919900 T2 DE68919900 T2 DE 68919900T2
Authority
DE
Germany
Prior art keywords
carboxyl group
containing polysaccharides
crosslinked carboxyl
polysaccharide
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68919900T
Other languages
English (en)
Other versions
DE68919900D1 (de
Inventor
Valle Francesco Dr Della
Aurelio Prof Romeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of DE68919900D1 publication Critical patent/DE68919900D1/de
Publication of DE68919900T2 publication Critical patent/DE68919900T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/005—Crosslinking of cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
DE68919900T 1988-05-13 1989-05-12 Vernetzte Karboxylgruppe enthaltende Polysaccharide. Expired - Lifetime DE68919900T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47964/88A IT1219587B (it) 1988-05-13 1988-05-13 Polisaccaridi carbossiilici autoreticolati

Publications (2)

Publication Number Publication Date
DE68919900D1 DE68919900D1 (de) 1995-01-26
DE68919900T2 true DE68919900T2 (de) 1995-05-11

Family

ID=11263644

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68929241T Expired - Lifetime DE68929241T2 (de) 1988-05-13 1989-05-12 Vernetzte Carboxypolysaccharide
DE68919900T Expired - Lifetime DE68919900T2 (de) 1988-05-13 1989-05-12 Vernetzte Karboxylgruppe enthaltende Polysaccharide.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68929241T Expired - Lifetime DE68929241T2 (de) 1988-05-13 1989-05-12 Vernetzte Carboxypolysaccharide

Country Status (17)

Country Link
US (1) US5676964A (de)
EP (2) EP0614914B1 (de)
JP (2) JP2941324B2 (de)
KR (1) KR0145089B1 (de)
AT (2) ATE195534T1 (de)
AU (1) AU631125B2 (de)
CA (1) CA1339122C (de)
DE (2) DE68929241T2 (de)
DK (1) DK175386B1 (de)
ES (2) ES2151910T3 (de)
FI (1) FI107050B (de)
GR (2) GR3015035T3 (de)
HU (1) HU210926B (de)
IL (1) IL90274A (de)
IT (1) IT1219587B (de)
NZ (1) NZ229100A (de)
WO (1) WO1989010941A1 (de)

Families Citing this family (244)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030958A (en) * 1987-09-18 2000-02-29 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6235726B1 (en) * 1987-09-18 2001-05-22 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
AU7312291A (en) * 1990-02-13 1991-09-03 Gere S. Dizerega Peritoneal induced medicaments
FR2659554B1 (fr) * 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
IL98087A (en) * 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
WO1991019470A1 (en) * 1990-06-14 1991-12-26 Vitaphore Corporation Polyurethane-biopolymer composite
US5833665A (en) * 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
GR920100122A (el) * 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
IT1247472B (it) 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5486582A (en) * 1991-07-03 1996-01-23 Shin-Etsu Chemical Co., Ltd. Polymer scale preventive process using a coating of chitosan salt and phenothiazine
IT1254170B (it) * 1991-12-18 1995-09-11 Mini Ricerca Scient Tecnolog Membrane composite per la rigenerazione guidata di tessuti
IT1254704B (it) * 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico
US5824335A (en) * 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5942498A (en) * 1992-02-20 1999-08-24 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
CA2076732C (en) * 1992-04-17 2006-05-09 Kimberly-Clark Worldwide, Inc. Modified polysaccharides having improved absorbent properties and process for the preparation thereof
US5550189A (en) * 1992-04-17 1996-08-27 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
IT1264322B (it) * 1992-07-30 1996-09-23 Lanfranco Callegaro Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie
IT1263144B (it) * 1993-02-04 1996-08-01 Lanfranco Callegaro Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive
IT1263316B (it) * 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
IT1263394B (it) 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Composizioni farmaceutiche per uso topico a base di acido ialuronico e suoi derivati
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
IT1268955B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Esteri attivi di polisaccaridi carbossilici
US5399362A (en) * 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
JP3279318B2 (ja) * 1994-04-25 2002-04-30 ペンウェスト ファーマシューティカルズ カンパニー 持続放出性賦形剤
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
PL182804B1 (pl) * 1995-02-07 2002-03-29 Fidia Advanced Biopolymers Sposób powlekania powierzchni przedmiotu kwasem hialuronowym lub pochodną kwasu hialuronowego i sposób powlekania powierzchni przedmiotu polimerem półsyntetycznym
US6096324A (en) * 1995-06-13 2000-08-01 Laboratory Skin Care Methods of delivering materials into the skin, and compositions used therein
US5612321A (en) * 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
ES2244975T3 (es) 1995-08-29 2005-12-16 Fidia Advanced Biopolymers S.R.L. Biomateriales para la prevencion de adherencias postquirurgicas, formados por derivados de acido hialuronico.
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
AU2068797A (en) * 1996-01-29 1997-08-20 Edward Mendell Co. Inc. Sustained release excipient
DE19619680A1 (de) * 1996-05-15 1997-11-20 Buna Sow Leuna Olefinverb Gmbh Verfahren zur Herstellung von superabsorbierenden Polymeren auf Stärkebasis
IT1288290B1 (it) * 1996-06-21 1998-09-11 Fidia Spa In Amministrazione S Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6632802B2 (en) * 1996-08-29 2003-10-14 Fidia Advanced Biopolymers S.R.L. Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
EP0927196B1 (de) * 1996-09-19 2008-11-05 The Regents Of The University Of Michigan Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate
ES2189166T3 (es) * 1997-04-04 2003-07-01 Fidia Advanced Biopolymers Srl Compuestos del acido hialuronico n-sulfatado, sus derivados y proceso para su preparacion.
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
IT1294797B1 (it) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
AU742675B2 (en) 1997-08-22 2002-01-10 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid gel, method of its production and medical material containing it
IT1296689B1 (it) * 1997-11-06 1999-07-14 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
US6872819B1 (en) 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
JP3459575B2 (ja) * 1998-09-06 2003-10-20 科学技術振興事業団 人工骨用高分子材料
CA2284962C (en) * 1998-11-04 2008-08-26 Kibun Food Chemifa Co., Ltd. Oil absorption retarder
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
IT1302534B1 (it) * 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
ATE376824T1 (de) 1999-01-13 2007-11-15 Alchemia Oncology Pty Ltd Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
GB9902412D0 (en) 1999-02-03 1999-03-24 Fermentech Med Ltd Process
US20040048021A1 (en) * 1999-03-19 2004-03-11 Wan Barbara Y. F. Surface modification of substrates
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
IT1306643B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica
US7128929B1 (en) * 1999-04-29 2006-10-31 Scherr George H Alginate foam compositions
US20010048940A1 (en) * 1999-06-18 2001-12-06 Jennifer D. Tousignant Cationic amphiphile micellar complexes
JP4819984B2 (ja) * 1999-06-23 2011-11-24 独立行政法人日本原子力研究開発機構 自己架橋型アルキルセルロース誘導体、及びそれらの製造方法
IT1306679B1 (it) * 1999-06-29 2001-10-02 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico per la preparazione dicomposizoni farmaceutiche e biomateriali per la prevenzione della
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
JP2001037472A (ja) 1999-07-28 2001-02-13 Bio Quest:Kk 三次元細胞培養基材及びそれを用いた細胞培養方法
CN100379462C (zh) 1999-11-09 2008-04-09 电气化学工业株式会社 一种包含难溶于水的可溶性纤维素衍生物的组织包被性医疗材料及其制造方法
DE10023540A1 (de) * 2000-05-13 2001-11-15 Clariant Gmbh Modifizierte Celluloseether, erhältlich durch Umsetzung von Celluloseethern mit freien Hydroxygruppen mit Di- und/oder Polycarbonsäuren unter Zusatz von Katalysatoren sowie Verfahren zu deren Herstellung
JP2002078733A (ja) * 2000-06-28 2002-03-19 Uni Charm Corp 吸収性物品
US9066919B2 (en) 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US6875862B2 (en) 2001-01-29 2005-04-05 Daicel Chemical Industries, Ltd. Self-cross-linked alkyl cellulose and processes for producing the same
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
DE10125599A1 (de) 2001-05-25 2002-11-28 Stockhausen Chem Fab Gmbh Superabsorber, Verfahren zu ihrer Herstellung und ihre Verwendung
ITTS20010016A1 (it) * 2001-06-20 2002-12-20 Ct Ricerche Poly Tec H A R L S Polisaccaridi regioselettivamente reticolati.
CN1578677A (zh) * 2001-08-27 2005-02-09 美迪泰克研究有限公司 改良的治疗方案
FR2828810B1 (fr) 2001-08-27 2005-10-07 Lvmh Rech Composition cosmetique a effet tenseur contenant un polymere d'origine naturelle et un agent hydratant polyhydroxyle
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
ITPD20020003A1 (it) 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US20030199951A1 (en) 2002-04-22 2003-10-23 Pardo Xavier E. Implantable lead with improved conductor lumens
EP1552839A4 (de) 2002-08-16 2011-11-02 Denki Kagaku Kogyo Kk Getrenntes medizinisches material
KR100507545B1 (ko) * 2002-09-03 2005-08-09 주식회사 엘지생명과학 히알루론산 유도체 및 그의 제조방법
ITPD20020271A1 (it) 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
WO2004046200A1 (ja) 2002-11-21 2004-06-03 Chugai Seiyaku Kabushiki Kaisha 薬物徐放担体
US7192451B2 (en) * 2002-12-05 2007-03-20 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Fabric treatment
PL377477A1 (pl) 2002-12-11 2006-02-06 Ferrosan A/S Materiały na bazie żelatyny jako waciki
US20040185022A1 (en) * 2003-02-19 2004-09-23 Steven Rubin Regimen for acne treatment
US7485719B2 (en) * 2003-02-21 2009-02-03 Terumo Kabushiki Kaisha Crosslinkable polysaccharide derivative, process for producing the same, crosslinkable polysaccharide composition, and medical treatment material
FR2861734B1 (fr) * 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
AU2003901834A0 (en) * 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
DE10325200A1 (de) * 2003-06-04 2004-12-30 Clariant Gmbh Herstellung von Saccharidestern
EP1639898A4 (de) * 2003-06-20 2008-05-07 Maekawa Seisakusho Kk Verfahren zum trennen von austernfleisch vom schenkel und vorrichtung dafür
JP4690892B2 (ja) * 2003-06-30 2011-06-01 電気化学工業株式会社 脊椎・脊髄手術用癒着防止材
WO2005012364A2 (fr) * 2003-07-30 2005-02-10 Anteis S.A. Matrice complexe a usage biomedical
GB2404920A (en) * 2003-08-12 2005-02-16 Johnson & Johnson Medical Ltd Antimicrobial polymer
CN102276732B (zh) 2003-11-28 2016-01-20 伊士曼化工公司 纤维素共聚体和氧化方法
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
JP4596774B2 (ja) * 2003-12-26 2010-12-15 独立行政法人 日本原子力研究開発機構 化粧料
AR054637A1 (es) 2004-01-30 2007-07-11 Ferrosan As Aerosoles y composiciones hemostaticas
ITPD20040053A1 (it) * 2004-02-27 2004-05-27 Fidia Advanced Biopolymers Srl Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
US7737214B2 (en) 2004-03-15 2010-06-15 Terumo Kabushiki Kaisha Adhesion preventive material
EP1750769B1 (de) * 2004-05-20 2013-01-23 Mentor Worldwide LLC Verfahren zur herstellung eines injizierbaren polymerhydrogels
ES2609105T3 (es) 2004-05-20 2017-04-18 Mentor Worldwide Llc Método de enlance covalente de ácido hialurónico y quitosano
US20050281855A1 (en) * 2004-06-18 2005-12-22 National Defense Medical Center Process for preparing a cross-linked carboxyl polysaccharide and the cross-linked carboxyl polysaccharide
EP1786480B1 (de) 2004-07-09 2016-09-21 Ferrosan Medical Devices A/S Hämostatische zusammensetzung mit hyaluronsäure
US7273756B2 (en) * 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US8017394B2 (en) * 2004-10-01 2011-09-13 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
GB0513552D0 (en) 2005-07-01 2005-08-10 Bristol Myers Squibb Co Bandage
JP5147396B2 (ja) 2005-07-06 2013-02-20 生化学工業株式会社 薬剤導入光架橋ヒアルロン酸誘導体ゲル
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
JP5465431B2 (ja) 2005-07-27 2014-04-09 アルケミア オンコロジー ピーティーワイ リミテッド ヒアルロナンを用いる治療プロトコル
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
AU2006289651B2 (en) 2005-09-07 2012-07-26 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
US7959943B2 (en) 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
EP2543340A1 (de) * 2006-05-19 2013-01-09 Trustees Of Boston University Neue hydrophile Polymere als medizinische Gleitmittel und Gele
ITMI20061726A1 (it) * 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
CA2662581C (en) 2006-09-13 2018-01-30 Enhance Skin Products, Inc. Cosmetic composition for the treatment of skin and methods thereof
EP2078528B1 (de) 2006-09-22 2013-08-14 Kochi University Strahlensensibilisator oder Chemotherapie-Sensibilisator gegen Krebs
US7935647B2 (en) * 2006-12-15 2011-05-03 E. I. Du Pont De Nemours And Company Laminates of acid polysaccharide films
EP1939219A1 (de) * 2006-12-29 2008-07-02 Sigea S.R.L. Mit Zitronensäure modifizierte Polysaccharide
EP1942117A1 (de) * 2006-12-29 2008-07-09 Sigea S.R.L. Derivate aus Carboxypolysacchariden
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
US20080293637A1 (en) 2007-05-23 2008-11-27 Allergan, Inc. Cross-linked collagen and uses thereof
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
US20110077737A1 (en) * 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
WO2009022358A1 (en) * 2007-08-10 2009-02-19 Luigi Ambrosio Superabsorbent polymer hydro gels and a method of preparing thereof
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
WO2009065116A1 (en) 2007-11-16 2009-05-22 Aspect Pharmaceuticals Llc Compositions and methods for treating purpura
US9345809B2 (en) * 2007-11-28 2016-05-24 Fziomed, Inc. Carboxymethylcellulose polyethylene glycol compositions for medical uses
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
EP2108676B1 (de) 2008-04-03 2017-12-27 OrganoClick AB Vernetztes papiermaterial
EP2291448B1 (de) * 2008-04-24 2017-01-04 Medtronic, Inc Rehydratisierbare polysaccharidteilchen und schwamm
US20090269417A1 (en) * 2008-04-24 2009-10-29 Medtronic, Inc. Thiolated chitosan gel
AU2009240509B2 (en) * 2008-04-24 2014-08-21 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
JP5833919B2 (ja) 2008-04-24 2015-12-16 メドトロニック，インコーポレイテッド キトサンと酸化多糖とに基づく保護用ゲル
EP2269665B1 (de) * 2008-05-01 2017-05-17 Terumo Kabushiki Kaisha Sichtbares medizinisches behandlungsmaterial
EP2303254B1 (de) 2008-06-12 2019-10-30 Medtronic Xomed, Inc. Produkt zur behandlung von chronischen wunden mit einem extrazellulären polymer-substanz-solvatisierungssystem
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
EP2324064B1 (de) 2008-09-02 2017-11-08 Tautona Group LP Stränge aus hyaluronsäure und/oder derivaten daraus, herstellungsverfahren und verwendung
AU2015201245B2 (en) * 2008-09-02 2016-07-07 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US20100086576A1 (en) 2008-10-06 2010-04-08 Myntti Matthew F Antimicrobial composition and methods of making and using same
DK2413894T3 (en) * 2009-04-02 2017-04-03 Allergan Inc HIGHLY FORMED HYDROGLES FOR SOFTWARE STRENGTH
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
IT1395392B1 (it) 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
US8273725B2 (en) 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
CZ2009835A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
AU2010348090B2 (en) 2010-03-12 2015-09-03 Allergan Industrie Sas A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition
ES2729994T3 (es) * 2010-03-22 2019-11-07 Allergan Inc Hidrogeles reticulados de polisacárido y proteína-polisacárido para aumento de tejido blando
ITMI20101479A1 (it) * 2010-08-03 2012-02-04 Principium Europ Srl Processo di reticolazione di polisaccaridi
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
ES2385239B1 (es) 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
CZ302994B6 (cs) 2010-12-31 2012-02-08 Cpn S.R.O. Hyaluronová vlákna, zpusob jejich prípravy a použití
US10653133B2 (en) 2011-05-10 2020-05-19 Next Science IP Holdings Pty Ltd Antimicrobial solid and methods of making and using same
ITTO20110428A1 (it) 2011-05-13 2012-11-14 Rottapharm Spa Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia
CN103702659B (zh) 2011-06-03 2016-12-21 阿勒根公司 包括抗氧化剂的皮肤填充剂组合物
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
AU2012267855B2 (en) 2011-06-07 2016-03-03 Gelesis Llc Method for producing hydrogels
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
FR2983483B1 (fr) 2011-12-02 2014-11-14 Vivacy Lab Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles
CZ2012136A3 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
ITPD20120098A1 (it) 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
ITPD20120173A1 (it) 2012-05-31 2013-12-01 Fidia Farmaceutici "nuovo sistema di rilascio di proteine idrofobiche"
JP6394916B2 (ja) 2012-06-12 2018-09-26 フェロサン メディカル デバイシーズ エイ／エス 乾燥止血組成物
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
KR20150065861A (ko) 2012-10-09 2015-06-15 시구마-토우인더스트리에파아마슈우티히리유니트에스.피이.에이. 변형된 히알우론산 유도체 및 이의 용도
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
ITPD20120360A1 (it) 2012-11-30 2014-05-31 Fidia Farmaceutici "nuovi geli viscoelastici in chirurgia oftalmica"
DE102013211316A1 (de) 2013-06-17 2014-12-18 Aesculap Ag Hämostyptikum
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10117892B2 (en) * 2013-08-29 2018-11-06 Allergan, Inc. Devices and methods for reducing the appearance of cellulite
JPWO2015053282A1 (ja) * 2013-10-08 2017-03-09 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法
WO2015053281A1 (ja) * 2013-10-08 2015-04-16 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
JP6081617B2 (ja) 2014-01-31 2017-02-15 生化学工業株式会社 ジアミン架橋剤、酸性多糖架橋体、及び医用材料
CZ305153B6 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
ES2897733T3 (es) 2014-06-15 2022-03-02 Yeda Res & Dev Tratamiento de superficies de lentes de contacto y tratamiento de molestias oculares mediante polímeros solubles en agua y lípidos/liposomas
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
PL229108B1 (pl) * 2014-08-22 2018-06-29 Celther Polska Spolka Z Ograniczona Odpowiedzialnoscia Sposób wydzielania i oczyszczania estrów chityny (mono-, di‑podstawionych) oraz kopoliestrów chityny z mieszanin poreakcyjnych
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス 止血および創傷治癒に使用するための乾燥組成物
JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 第１の物質と第２の物質を保持し混合するためのシリンジ
MX2017009805A (es) 2015-01-29 2018-05-07 Gelesis Llc Método para la producción de hidrogeles que juntan alto módulo elástico y absorbancia.
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
SG10201913342UA (en) 2016-04-27 2020-03-30 Anika Therapeutics Inc Compositions for use in treating tendon degeneration
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
MA49265A (fr) 2017-03-22 2020-02-05 Ascendis Pharma As Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
JP2019019201A (ja) * 2017-07-14 2019-02-07 キユーピー株式会社 架橋ヒアルロン酸、及びその製造方法
IT201700122135A1 (it) * 2017-10-26 2019-04-26 Jointherapeutics S R L Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori
CA3087820A1 (en) 2018-01-10 2019-07-18 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin System and methods for sealing a channel in tissue
WO2020144372A1 (en) 2019-01-10 2020-07-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
IT201800001890A1 (it) 2018-01-25 2019-07-25 Fidia Farm Spa Composizioni farmaceutiche per il trattamento del dolore postoperatorio
IT201900006250A1 (it) 2019-04-23 2020-10-23 Fidia Farm Spa Medicazione per il trattamento della cute lesa
JP7395113B2 (ja) 2018-05-09 2023-12-11 フェロサン メディカル デバイシーズ エイ／エス 止血組成物を調製する方法
JP6815561B2 (ja) 2018-06-14 2021-01-20 持田製薬株式会社 新規な架橋アルギン酸
WO2020240034A1 (en) 2019-05-31 2020-12-03 University College Dublin Hyaluronic acid-based hybrid hydrogel
IT201900021693A1 (it) * 2019-11-20 2021-05-20 Bmg Pharma S P A Derivati butirrati o butirrati e formiati dell’acido ialuronico reticolati e loro procedimento di reticolazione
CN114929754A (zh) 2019-12-18 2022-08-19 持田制药株式会社 新型交联海藻酸
IT202000005692A1 (it) 2020-03-17 2021-09-17 Fidia Farm Spa Bio-inchiostro per stampa 3D, relativo coniugato e processo di preparazione di un intermedio costituito da un linker fotoreattivo
AU2021292668A1 (en) 2020-06-15 2023-02-09 KORTUC Japan LLC Sensitiser for cancer treatment
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo
TW202333793A (zh) 2022-01-11 2023-09-01 義大利商Ｇｐｑ有限公司 作為創新填充劑之新玻尿酸衍生物
CN114478831B (zh) * 2022-01-21 2023-06-27 湖南益安生物科技有限公司 一种高分子材料及其制备方法与应用
WO2023169949A1 (en) 2022-03-10 2023-09-14 Cmed Aesthetics S.R.L. Process for the preparation of sterile products
EP4335876A1 (de) 2022-09-06 2024-03-13 Scivision Biotech Inc. Verfahren zur herstellung von selbstvernetztem hyaluronsäuregel und produkte daraus

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2481804A (en) * 1944-07-04 1949-09-13 Biotic Res Inst Inc Penicillin-pectin composition and method of manufacture
DE1239284B (de) * 1963-01-23 1967-04-27 Vaessen Schoemaker Holding Bv Verfahren zur Herstellung von in Wasser leicht gelierbaren Carboxymethylderivaten der Amylose oder der Staerke
GB1086323A (en) * 1963-07-18 1967-10-11 Courtaulds Ltd Derivative of carboxy methyl cellulose
US3792164A (en) * 1970-03-31 1974-02-12 Chemway Corp Ophthalmic composition comprising water-soluble alkaloid salts of polyuronic acids
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
IT1229075B (it) * 1985-04-05 1991-07-17 Fidia Farmaceutici Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
DE3245784A1 (de) * 1982-12-10 1984-06-14 Wella Ag, 6100 Darmstadt Kosmetisches mittel auf der basis von quaternaeren chitosanderivaten, neue quaternaere chitosanderivate sowie verfahren zu ihrer herstellung
US4521594A (en) * 1983-05-20 1985-06-04 Daicel Chemical Industries, Ltd. Process for producing sodium carboxymethylcellulose
SE442820B (sv) * 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
JPS6117A (ja) * 1984-06-11 1986-01-06 Seikagaku Kogyo Co Ltd ムコ多糖系癌転移抑制剤
US4605691A (en) * 1984-12-06 1986-08-12 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) * 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
SE8501022L (sv) * 1985-03-01 1986-09-02 Pharmacia Ab Format alster och forfarande for dess framstellning
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
SE8501723L (sv) * 1985-04-09 1986-10-10 Pharmacia Ab Preparation att anvendas vid behandling av ledinflammation
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
SE452469B (sv) * 1986-06-18 1987-11-30 Pharmacia Ab Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid

Also Published As

Publication number Publication date
HU893636D0 (en) 1990-09-28
GR3034651T3 (en) 2001-01-31
AU3574789A (en) 1989-11-29
ATE115590T1 (de) 1994-12-15
JPH10324701A (ja) 1998-12-08
CA1339122C (en) 1997-07-29
IT1219587B (it) 1990-05-18
DE68919900D1 (de) 1995-01-26
IT8847964A0 (it) 1988-05-13
DE68929241T2 (de) 2001-04-05
HU210926B (en) 1995-09-28
ES2151910T3 (es) 2001-01-16
EP0614914A2 (de) 1994-09-14
ATE195534T1 (de) 2000-09-15
JP2941324B2 (ja) 1999-08-25
ES2064378T3 (es) 1995-02-01
KR900701849A (ko) 1990-12-04
IL90274A (en) 1996-09-12
DK10990D0 (da) 1990-01-12
EP0614914A3 (de) 1994-12-28
AU631125B2 (en) 1992-11-19
DE68929241D1 (de) 2000-09-21
IL90274A0 (en) 1989-12-15
GR3015035T3 (en) 1995-05-31
JPH02504163A (ja) 1990-11-29
EP0614914B1 (de) 2000-08-16
NZ229100A (en) 1995-08-28
FI107050B (fi) 2001-05-31
EP0341745A1 (de) 1989-11-15
EP0341745B1 (de) 1994-12-14
DK175386B1 (da) 2004-09-20
FI900188A0 (fi) 1990-01-12
WO1989010941A1 (en) 1989-11-16
KR0145089B1 (ko) 1998-07-01
US5676964A (en) 1997-10-14
DK10990A (da) 1990-03-12
HUT53666A (en) 1990-11-28

Similar Documents

Publication Publication Date Title
ATE115590T1 (de) Vernetzte karboxylgruppe enthaltende polysaccharide.
ATE114322T1 (de) Ester von polysacchariden.
EP0265116A3 (de) Vernetzte Ester von Hyaluronsäure
BR9711036A (pt) Amido ou mistura de polímeros de derivados de amido processáveis de maneira termoplástica.
PT1144459E (pt) Acidos hialuronicos reticulados e as suas utilizacoes em medicina
IT8621782A1 (it) Composizioni di polimeri degradabili in modo controllabile e rapido e pellicole e altri prodotti fabbricati da esse
IT1264322B (it) Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie
ATE211153T1 (de) Alkyd- oder aralkydderivate von phenolischen polymeren
ATE183688T1 (de) Umweltsicherer verbundwerkstoff
WO2003008457A3 (en) Polysaccharidic esters of retinoic acid
DE69121666D1 (de) Verfahren zur Herstellung von Epoxy-Hepariden; die so hergestellten Produkte und diese enthaltende pharmazeutische Zusammensetzungen
KR900007431A (ko) 내혈전성 재료 및 이것을 제조하는 방법
DE382180T1 (de) Derivate von thiazolidin-4-carbonsaeure, deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE69003057D1 (de) Ester von Alkylthiopropionsäuren mit Pentaerythrit und deren Reinigung mit Lösungsmittel.
YU149391A (sh) Estri monokarboksilne kiseline i olefinski polimerni preparat stabilisan sa njima
Yalpani Polymeric Biomaterials, Edited by Severian Dumitriu, Marcel Dekker, New York, ISBN 0-8247-8969-5, x+ 845 pp, 1994, $195.00
RU93050741A (ru) Буж

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: HARTMANN, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 81679 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: FIDIA FARMACEUTICI S.P.A., ABANO TERME, PADUA/PADO

8328 Change in the person/name/address of the agent

Representative=s name: SEITZ, R., DIPL.-ING.UNIV., PAT.-ANW., 80538 MUENC