DE60232688D1 - Grenzflächen-biomaterialien - Google Patents

Grenzflächen-biomaterialien

Info

Publication number
DE60232688D1
DE60232688D1 DE60232688T DE60232688T DE60232688D1 DE 60232688 D1 DE60232688 D1 DE 60232688D1 DE 60232688 T DE60232688 T DE 60232688T DE 60232688 T DE60232688 T DE 60232688T DE 60232688 D1 DE60232688 D1 DE 60232688D1
Authority
DE
Germany
Prior art keywords
binding
biological substrate
ligand
methods
biomaterials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60232688T
Other languages
English (en)
Inventor
Mark W Grinstaff
Daniel J Kenan
Elisabeth B Walsh
Crystan Middleton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27765921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60232688(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Duke University filed Critical Duke University
Application granted granted Critical
Publication of DE60232688D1 publication Critical patent/DE60232688D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
DE60232688T 2001-11-20 2002-11-20 Grenzflächen-biomaterialien Expired - Lifetime DE60232688D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33184301P 2001-11-20 2001-11-20
PCT/US2002/037414 WO2003072542A2 (en) 2001-11-20 2002-11-20 Interfacial biomaterials

Publications (1)

Publication Number Publication Date
DE60232688D1 true DE60232688D1 (de) 2009-07-30

Family

ID=27765921

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60232688T Expired - Lifetime DE60232688D1 (de) 2001-11-20 2002-11-20 Grenzflächen-biomaterialien

Country Status (9)

Country Link
US (4) US20030185870A1 (de)
EP (1) EP1527341B1 (de)
JP (1) JP2005518442A (de)
AT (1) ATE434184T1 (de)
AU (1) AU2002367566B2 (de)
CA (1) CA2467836A1 (de)
DE (1) DE60232688D1 (de)
ES (1) ES2327398T3 (de)
WO (1) WO2003072542A2 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7722894B2 (en) * 2001-10-22 2010-05-25 Massachusetts Institute Of Technology Biodegradable polymer
WO2003106640A2 (en) 2002-06-14 2003-12-24 Case Western Reserve University Cell targeting methods and compositions
JP2006517186A (ja) * 2002-09-04 2006-07-20 ボード オブ リージェンツ ユニバーシティ オブ テキサス システム 二機能性の生体材料の組成物、方法、および使用
US20060263336A1 (en) * 2003-03-24 2006-11-23 Caplan Arnold I Cell targeting methods and compositions
WO2004087860A2 (en) * 2003-03-31 2004-10-14 University Of South Florida Materials and methods for regulating process formation in cell culture
EP1661910B1 (de) * 2003-07-30 2013-09-18 Japan Science and Technology Agency Peptide, die dazu in der lage sind, titan, silber und silikon zu binden
US7807141B2 (en) * 2003-09-08 2010-10-05 E.I. Du Pont De Nemours And Company Peptide-based oral care surface reagents for personal care
US20050226839A1 (en) * 2003-09-08 2005-10-13 Xueying Huang Pepetide-based body surface reagents for personal care
US7285264B2 (en) * 2003-09-08 2007-10-23 E.I. Du Pont De Nemours And Company Peptide-based body surface coloring reagents
US7585495B2 (en) 2003-09-08 2009-09-08 E. I. Du Pont De Nemours And Company Method for identifying shampoo-resistant hair-binding peptides and hair benefit agents therefrom
US20100311641A1 (en) * 2003-09-08 2010-12-09 E. I. Du Pont De Nemours And Company Peptide-based body surface coloring reagents
US7220405B2 (en) * 2003-09-08 2007-05-22 E. I. Du Pont De Nemours And Company Peptide-based conditioners and colorants for hair, skin, and nails
US20060234210A1 (en) * 2004-04-14 2006-10-19 Affinergy, Inc. Filtration device and method for removing selected materials from biological fluids
US7276088B2 (en) * 2004-04-15 2007-10-02 E.I. Du Pont De Nemours And Company Hair coloring and cosmetic compositions comprising carbon nanotubes
US7452528B2 (en) * 2004-04-15 2008-11-18 E.I. Du Pont De Nemours And Company Peptide-based carbon nanotube hair colorants and their use in hair colorant and cosmetic compositions
ES2342551T3 (es) * 2004-06-16 2010-07-08 Affinergy Inc Biomateriales interfaciales (ifbm) para promover la adhesion especifica de substancias a analizar.
WO2006005361A1 (en) * 2004-07-13 2006-01-19 Centre National De La Recherche Scientifique Peptides liable to bind to the tie2 receptor, nucleic acids encoding them, and their uses
US8398638B2 (en) 2004-08-30 2013-03-19 Spineovations, Inc. Method of treating spinal internal disk derangement
US20060199206A1 (en) * 2005-03-01 2006-09-07 Hong Wang Method for identifying skin care composition-resistant skin-binding peptides
US20060286047A1 (en) * 2005-06-21 2006-12-21 Lowe David J Methods for determining the sequence of a peptide motif having affinity for a substrate
US20070065387A1 (en) * 2005-09-16 2007-03-22 Beck William A Method for enhancing the effect of particulate benefit agents
US7736633B2 (en) * 2005-09-28 2010-06-15 E.I. Du Pont De Nemours And Company Method for enhancing effects of colorants and conditioners
US20070129690A1 (en) 2005-12-02 2007-06-07 Joel Rosenblatt Catheter with polymeric coating
US7709601B2 (en) * 2005-12-15 2010-05-04 E. I. Du Pont De Nemours And Company Nylon binding peptides and methods of use
US7858581B2 (en) * 2005-12-15 2010-12-28 E. I. Du Pont De Nemours And Company PMMA binding peptides and methods of use
US7906617B2 (en) 2005-12-15 2011-03-15 E. I. Du Pont De Nemours And Company Polyethylene binding peptides and methods of use
US7700716B2 (en) * 2005-12-15 2010-04-20 E. I. Du Pont De Nemours And Company Polytetrafluoroethylene binding peptides and methods of use
US7928076B2 (en) * 2005-12-15 2011-04-19 E. I. Du Pont De Nemours And Company Polypropylene binding peptides and methods of use
US7632919B2 (en) * 2005-12-15 2009-12-15 E.I. Du Pont De Nemours And Company Polystyrene binding peptides and methods of use
US7807624B2 (en) 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
US7531505B2 (en) * 2006-01-11 2009-05-12 Affinergy, Inc. Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices
US20090011486A1 (en) * 2006-01-12 2009-01-08 Massachusetts Institute Of Technology Biodegradable Elastomers
WO2007082304A2 (en) 2006-01-12 2007-07-19 Massachusetts Institute Of Technology Biodegradable elastomers
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
US20080015138A1 (en) * 2006-07-17 2008-01-17 Affinergy, Inc. Metal binding compounds, metal binding compositions, and their uses
US20080070802A1 (en) * 2006-08-23 2008-03-20 Moerschell Richard P Directed heterobifunctional linkers
US20100234568A1 (en) * 2006-10-19 2010-09-16 Linda Jane Decarolis Identification of peptide tags for the production of insoluble peptides by sequence scanning
US7662913B2 (en) 2006-10-19 2010-02-16 E. I. Du Pont De Nemours And Company Cystatin-based peptide tags for the expression and purification of bioactive peptides
US7732569B2 (en) 2006-10-19 2010-06-08 E.I. Du Pont De Nemours And Company Zein-based peptide tags for the expression and purification of bioactive peptides
US8912304B2 (en) * 2007-05-17 2014-12-16 Massachusetts Institute Of Technology Polyol-based polymers
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7754680B2 (en) 2007-07-26 2010-07-13 E. I. Du Pont De Nemours And Company Peptides for binding calcium carbonates and methods of use
US8067021B2 (en) * 2007-09-04 2011-11-29 Affinergy, Inc. Methods and compositions for delivery of growth factor to fibrous connective tissue
WO2009079066A2 (en) * 2007-09-26 2009-06-25 Aparna Biosciences Therapeutic and vaccine polyelectrolyte nanoparticle compositions
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
WO2009085096A2 (en) * 2007-12-05 2009-07-09 Semprus Biosciences Corporation Non-leaching, non-fouling antimicrobial coatings
US20090149673A1 (en) * 2007-12-05 2009-06-11 Semprus Biosciences Corp. Synthetic non-fouling amino acids
US20100010549A1 (en) * 2008-03-05 2010-01-14 Neville Alleyne device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries
US8469961B2 (en) * 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
US20090246248A1 (en) * 2008-03-27 2009-10-01 Affinergy Coating compositions having improved performance
US7700923B2 (en) * 2008-09-20 2010-04-20 Varian Medical Systems, Inc. Apparatus of photoconductor crystal growth
US20100082097A1 (en) * 2008-10-01 2010-04-01 Joel Rosenblatt Article Containing Segregated Biguanide and Lewis Acid
GB0818614D0 (en) * 2008-10-10 2008-11-19 Univ Dublin City Platelet Analysis
US8580240B1 (en) 2008-11-19 2013-11-12 University Of Kentucky Research Foundation Compounds and methods for reducing the occurrence of post-surgical adhesions
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100158822A1 (en) * 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US8697654B2 (en) * 2008-12-18 2014-04-15 E I Du Pont De Nemours And Company Peptide linkers for effective multivalent peptide binding
US7915011B2 (en) * 2009-03-05 2011-03-29 E.I. Du Pont De Nemours And Company Host cell modifications that improve peptide production and downstream processing
WO2010114638A1 (en) 2009-03-30 2010-10-07 E. I. Du Pont De Nemours And Company Peptide-based tooth whitening reagents
CA2758049A1 (en) 2009-03-30 2010-10-14 E.I. Du Pont De Nemours And Company Peptide-based systems for delivery of cosmetic agents
US8460269B2 (en) * 2009-09-14 2013-06-11 University of Pittsburgh—of the Commonwealth System of Higher Education Directed cell-based therapy using microbubble tagged cells
EP2491056B1 (de) * 2009-10-22 2021-09-15 Universiteit Twente Vhh zur anwendung bei gewebereperatur, organregeneration, organaustausch und gewebekonstruktion
JP5655254B2 (ja) * 2010-02-16 2015-01-21 国立大学法人京都工芸繊維大学 ポリカーボネートおよび／またはポリメタクリル酸メチル親和性ペプチド、およびその利用
US8609621B2 (en) 2010-11-15 2013-12-17 E I Du Pont De Nemours And Company Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
US9273336B2 (en) 2011-02-21 2016-03-01 E. I. Du Pont De Nemours And Company Recombinant host cells having an increase in buoyant density
EP2967665B1 (de) * 2011-02-28 2020-03-25 Tissue Regeneration Systems, Inc. Modulare gewebegerüste
US9000063B2 (en) 2011-12-14 2015-04-07 Semprus Biosciences Corporation Multistep UV process to create surface modified contact lenses
US8870372B2 (en) 2011-12-14 2014-10-28 Semprus Biosciences Corporation Silicone hydrogel contact lens modified using lanthanide or transition metal oxidants
JP2015508425A (ja) 2011-12-14 2015-03-19 センプラス・バイオサイエンシーズ・コーポレイションＳｅｍｐｒｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐ． 表面改質したコンタクトレンズ
CA2859195C (en) 2011-12-14 2016-09-27 Semprus Biosciences Corp. Imbibing process for contact lens surface modification
AU2012352003B2 (en) 2011-12-14 2015-10-01 Arrow International, Inc. Redox processes for contact lens modification
US8988729B2 (en) * 2012-04-24 2015-03-24 Medimind, LLC System and method for printing a pharmaceutical label
US10292381B2 (en) 2012-07-20 2019-05-21 The General Hospital Corporation Vessel treatment systems, methods, and kits
US10549112B2 (en) 2012-07-20 2020-02-04 The General Hospital Corporation Apparatus for tissue irradiation and methods and kits utilizing the same
WO2014015274A1 (en) * 2012-07-20 2014-01-23 The General Hospital Corporation Methods for tissue passivation
WO2015009992A1 (en) 2013-07-18 2015-01-22 The General Hospital Corporation Vessel treatment systems, methods, and kits
JP2014117268A (ja) * 2012-12-19 2014-06-30 Kyoto Institute Of Technology 修飾ポリペプチドを用いた培養面のコーティング
CN104447956A (zh) * 2014-11-14 2015-03-25 陕西天瑞生物科技有限公司 聚氨酯界面特异性亲和多肽及其筛选方法
CA2973727A1 (en) 2015-01-16 2016-07-21 Spineovations, Inc. Method of treating spinal disk
US20190352710A1 (en) * 2017-01-05 2019-11-21 Virginia Commonwealth University System, method, computer-accessible medium and apparatus for dna mapping
CN116570753B (zh) * 2023-07-13 2023-09-22 健诺维(成都)生物科技有限公司 一种组织再生型生物膜组织复合物及制备方法及应用

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215A (en) * 1845-09-30 Mode of driving- bobbins in spinners
US3987797A (en) * 1974-02-25 1976-10-26 Ethicon, Inc. Antimicrobial sutures
US4230797A (en) * 1975-04-28 1980-10-28 Miles Laboratories, Inc. Heterogenous specific binding assay employing a coenzyme as label
IL51354A (en) * 1977-01-28 1979-07-25 Ames Yissum Ltd Assay method for the quantitative determination of a hapten in aqueous solution
US4279992A (en) * 1978-03-13 1981-07-21 Miles Laboratories, Inc. Specific binding assay employing an enzyme-cleavable substrate as label
JPS5510590A (en) * 1978-05-04 1980-01-25 Wellcome Found Enzyme immunity quantity analysis
US4228237A (en) * 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
US4253995A (en) * 1980-02-11 1981-03-03 Scripps Clinic And Research Foundation Immunochemical conjugates: method and composition
US4378224A (en) 1980-09-19 1983-03-29 Nimni Marcel E Coating for bioprosthetic device and method of making same
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4960423A (en) 1982-11-17 1990-10-02 Smith Donald W Method of enhancing the attachment of endothelial cells on a matrix and vascular prosthesis with enhanced anti-thrombogenic characteristics
US4708933A (en) * 1984-06-12 1987-11-24 Leaf Huang Immunoliposome assay-methods and products
US6492107B1 (en) * 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
GB2183661B (en) * 1985-03-30 1989-06-28 Marc Ballivet Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US4839293A (en) * 1986-02-24 1989-06-13 The Trustees Of Columbia University In The City Of New York DNA encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof
CA1335721C (en) * 1987-12-24 1995-05-30 Patrick E. Guire Biomolecule attached to a solid surface by means of a spacer and methods of attaching biomolecules to surfaces
US5266684A (en) * 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5019393A (en) * 1988-08-03 1991-05-28 New England Deaconess Hospital Corporation Biocompatible substance with thromboresistance
US5126140A (en) * 1988-08-03 1992-06-30 New England Deaconess Hospital Corporation Thrombomodulin-coated bicompatible substance
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5635482A (en) * 1989-08-14 1997-06-03 The Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
DE4002897A1 (de) 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5292362A (en) * 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5770434A (en) * 1990-09-28 1998-06-23 Ixsys Incorporated Soluble peptides having constrained, secondary conformation in solution and method of making same
US6258530B1 (en) * 1990-09-28 2001-07-10 Ixsys, Inc. Surface expression libraries of randomized peptides
US6225447B1 (en) 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5733731A (en) * 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
CA2117588C (en) 1992-02-28 1998-08-25 Jeffrey A. Hubbell Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6107059A (en) * 1992-04-29 2000-08-22 Affymax Technologies N.V. Peptide library and screening method
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
EP0628078B1 (de) * 1992-12-11 1999-12-08 The Dow Chemical Company Multivalente einkettige Antikörper
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
US6180239B1 (en) 1993-10-04 2001-01-30 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5840301A (en) 1994-02-10 1998-11-24 Imclone Systems Incorporated Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors
MX9504664A (es) * 1994-03-07 1997-05-31 Dow Chemical Co Conjugados de dendrimeros bioactivos y/o dirigidos.
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US5738996A (en) * 1994-06-15 1998-04-14 Pence, Inc. Combinational library composition and method
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
WO1996013583A2 (en) * 1994-10-20 1996-05-09 Morphosys Gesellschaft Für Proteinoptimierung Mbh Targeted hetero-association of recombinant proteins to multi-functional complexes
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5677276A (en) * 1994-12-23 1997-10-14 La Jolla Cancer Research Foundation Immobilization of peptides to hyaluronate
US5702892A (en) 1995-05-09 1997-12-30 The United States Of America As Represented By The Department Of Health And Human Services Phage-display of immunoglobulin heavy chain libraries
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
WO1997000271A1 (en) 1995-06-14 1997-01-03 The Regents Of The University Of California Novel high affinity human antibodies to tumor antigens
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
US5840300A (en) * 1995-09-11 1998-11-24 Trustees Of The University Of Pennsylvania Methods and compositions comprising single chain recombinant antibodies
US6068829A (en) * 1995-09-11 2000-05-30 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo
IE80466B1 (en) * 1995-11-10 1998-07-29 Elan Corp Plc Peptides which enhance transport across tissues and methods of identifying and using the same
FR2741892B1 (fr) 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
EP0800901B1 (de) 1996-04-10 2003-07-02 Dieffenbacher Schenck Panel GmbH Verfahren zur Herstellung eines Vlieses und Vorrichtung
US5928627A (en) 1996-04-19 1999-07-27 The Dow Chemical Company Fluorescent chelates as visual tissue specific imaging agents
JP3719546B2 (ja) 1996-04-22 2005-11-24 株式会社エーアンドエーマテリアル 珪酸カルシウム板及びその製造方法
GB9712818D0 (en) * 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
US5787584A (en) 1996-08-08 1998-08-04 General Motors Corporation Catalytic converter
CA2265484C (en) 1996-09-10 2008-12-02 The Burnham Institute Tumor homing molecules, conjugates derived therefrom, and methods of using same
US6048623A (en) 1996-12-18 2000-04-11 Kimberly-Clark Worldwide, Inc. Method of contact printing on gold coated films
KR100566859B1 (ko) 1997-01-21 2006-04-03 제너럴 하스피톨 코포레이션 Ｒｎａ-단백질 융합물을 이용한 단백질의 선별
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
CN1256635A (zh) * 1997-05-22 2000-06-14 默克专利股份有限公司 肽包被的植入物及其制备方法
US6180084B1 (en) * 1998-08-25 2001-01-30 The Burnham Institute NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same
US6140127A (en) * 1998-02-18 2000-10-31 Cordis Corporation Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
US6121236A (en) * 1998-03-24 2000-09-19 The Children's Medical Center Corporation Multivalent ligands which modulate angiogenesis
US6180348B1 (en) * 1998-04-20 2001-01-30 Weihua Li Method of isolating target specific oligonucleotide ligands
US6844171B1 (en) * 1998-07-02 2005-01-18 President And Fellows Of Harvard College Oligomerization of hepatitis delta antigen
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
AU6608600A (en) 1999-07-29 2001-02-19 University Of Vermont And State Agricultural College, The In vivo methods for the identification of target specific binding molecules in a human and their use in cancer detection
US20040018203A1 (en) * 2001-06-08 2004-01-29 Ira Pastan Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates
JP2006517186A (ja) * 2002-09-04 2006-07-20 ボード オブ リージェンツ ユニバーシティ オブ テキサス システム 二機能性の生体材料の組成物、方法、および使用

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EP1527341A4 (de) 2006-09-20
JP2005518442A (ja) 2005-06-23
US20030185870A1 (en) 2003-10-02
CA2467836A1 (en) 2003-09-04
EP1527341B1 (de) 2009-06-17
US20060263830A1 (en) 2006-11-23
WO2003072542A2 (en) 2003-09-04
US20060263831A1 (en) 2006-11-23
ATE434184T1 (de) 2009-07-15
EP1527341A2 (de) 2005-05-04
AU2002367566A1 (en) 2003-09-09
US20060216772A1 (en) 2006-09-28
WO2003072542A3 (en) 2005-03-10
ES2327398T3 (es) 2009-10-29

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