DE60230907D1 - Fibroinzusammensetzungen und verfahren zu deren herstellung - Google Patents

Fibroinzusammensetzungen und verfahren zu deren herstellung

Info

Publication number
DE60230907D1
DE60230907D1 DE60230907T DE60230907T DE60230907D1 DE 60230907 D1 DE60230907 D1 DE 60230907D1 DE 60230907 T DE60230907 T DE 60230907T DE 60230907 T DE60230907 T DE 60230907T DE 60230907 D1 DE60230907 D1 DE 60230907D1
Authority
DE
Germany
Prior art keywords
suspensions
fibroin solutions
repair
composites
tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60230907T
Other languages
English (en)
Inventor
Anthony T Dibenedetto
Claudio Migliaresi
Antonella Motta
Samuel Jien-Shek Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Original Assignee
University of Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Application granted granted Critical
Publication of DE60230907D1 publication Critical patent/DE60230907D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0095—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3865—Dental/periodontal tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
DE60230907T 2001-10-25 2002-10-25 Fibroinzusammensetzungen und verfahren zu deren herstellung Expired - Lifetime DE60230907D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34300601P 2001-10-25 2001-10-25
PCT/US2002/034252 WO2003035124A2 (en) 2001-10-25 2002-10-25 Fibroin compositions and methods of making the same

Publications (1)

Publication Number Publication Date
DE60230907D1 true DE60230907D1 (de) 2009-03-05

Family

ID=23344279

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60230907T Expired - Lifetime DE60230907D1 (de) 2001-10-25 2002-10-25 Fibroinzusammensetzungen und verfahren zu deren herstellung

Country Status (10)

Country Link
US (3) US7727542B2 (de)
EP (1) EP1446169B1 (de)
JP (1) JP4669662B2 (de)
CN (1) CN1277584C (de)
AT (1) ATE420671T1 (de)
AU (1) AU2002348072A1 (de)
CA (1) CA2466001C (de)
DE (1) DE60230907D1 (de)
ES (1) ES2321915T3 (de)
WO (1) WO2003035124A2 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127563A1 (en) * 2002-03-22 2004-07-01 Deslauriers Richard J. Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions
JP3772207B2 (ja) * 2002-06-19 2006-05-10 独立行政法人農業生物資源研究所 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材
WO2005046746A2 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US8673021B2 (en) 2003-11-26 2014-03-18 Depuy Mitek, Llc Arthroscopic tissue scaffold delivery device
EP1789088A4 (de) 2004-03-24 2009-12-30 Doctor S Res Group Inc Verfahren zur durchführung von medizinischen verfahren zur förderung des knochenwachstums, verfahren zur herstellung von zusammensetzungen zur förderung des knochenwachstums und gerät zur verwendung bei solchen verfahren
US7758896B2 (en) * 2004-04-16 2010-07-20 University Of Massachusetts Porous calcium phosphate networks for synthetic bone material
US20050244499A1 (en) * 2004-05-03 2005-11-03 Robert Diaz Method and device for reducing susceptibility to fractures in long bones
US20050244451A1 (en) * 2004-05-03 2005-11-03 Robert Diaz Method and device for reducing susceptibility to fractures in vertebral bodies
JP2008502739A (ja) 2004-06-11 2008-01-31 トラスティーズ オブ タフツ カレッジ 絹に基づく薬物送達システム
US20060089642A1 (en) * 2004-10-27 2006-04-27 Diaz Robert L Prefracture spinal implant for osteoporotic unfractured bone
EP1812090A1 (de) * 2004-10-28 2007-08-01 Microchips, Inc. Orthopädische und dentale implantate mit kontrollierter arzneimittelfreisetzung
KR100762928B1 (ko) 2004-10-29 2007-10-04 재단법인서울대학교산학협력재단 견 피브로인 나노섬유로 이루어진 부직포 형태의 골조직유도 재생용 차폐막 및 그 제조방법
US7713542B2 (en) 2005-01-14 2010-05-11 Ada Foundation Three dimensional cell protector/pore architecture formation for bone and tissue constructs
WO2007001624A2 (en) * 2005-06-28 2007-01-04 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
JP2007054278A (ja) * 2005-08-24 2007-03-08 Kyushu Institute Of Technology 人工骨用ペースト
US8518123B2 (en) * 2005-09-09 2013-08-27 Board Of Trustees Of The University Of Arkansas System and method for tissue generation and bone regeneration
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US20100068239A1 (en) * 2005-10-17 2010-03-18 Ugo Ripamonti Osteogenic Device for Inducing Bone Formation in Clinical Contexts
US8017237B2 (en) * 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
DE102006042142A1 (de) 2006-09-06 2008-03-27 Curasan Ag Phasen- und sedimentationsstabile, plastisch verformbare Zubereitung mit intrinsischer Porenbildung, bspw. zum Auffüllen von Knochendefekten bzw. zur Verwendung als Knochenersatzmaterial, und Verfahren zu deren Herstellung
US20100028451A1 (en) 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
KR100841742B1 (ko) * 2006-12-14 2008-06-27 화인코주식회사 하이드로겔 마스크 팩, 이의 제조 방법 및 이의 제조에이용되는 조성물
KR100955075B1 (ko) * 2007-10-10 2010-04-30 대한민국(농촌진흥청장) 실크 펩타이드를 활성성분으로 함유하는 골다공증 예방 및치료용 조성물
US9504575B2 (en) * 2008-02-07 2016-11-29 Trustees Of Tufts College 3-dimensional silk hydroxyapatite compositions
US20110212501A1 (en) * 2008-09-12 2011-09-01 The Brigham And Women's Hospital, Inc. 3-dimensional multi-layered hydrogels and methods of making the same
MX2011003618A (es) * 2008-10-09 2011-06-16 Tufts College Peliculas de seda modificadas que contienen glicerol.
TR201901133T4 (tr) * 2008-11-20 2019-02-21 Cartiheal 2009 Ltd Doku Onarımı İçin Katı Formlar
US9308070B2 (en) 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
FI20095084A0 (fi) 2009-01-30 2009-01-30 Pekka Vallittu Komposiitti ja sen käyttö
AU2010257120A1 (en) * 2009-03-04 2011-10-27 Trustees Of Tufts College Silk fibroin systems for antibiotic delivery
US20110189292A1 (en) * 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
US20110111031A1 (en) * 2009-04-20 2011-05-12 Guang-Liang Jiang Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof
US20110008406A1 (en) * 2009-04-20 2011-01-13 Altman Gregory H Silk Fibroin Hydrogels and Uses Thereof
US20110052695A1 (en) * 2009-04-20 2011-03-03 Allergan, Inc. Drug delivery platforms comprising silk fibroin hydrogels and uses thereof
EP2453931A4 (de) 2009-07-14 2014-04-30 Tufts College Wundheilungssysteme mit einem elektrogesponnenen seidenmaterial
KR101053118B1 (ko) 2009-10-14 2011-08-01 대한민국(농촌진흥청장) 골 재생용 실크/하이드록시아파타이트 복합 나노섬유 지지체의 제조방법
US9138308B2 (en) 2010-02-03 2015-09-22 Apollo Endosurgery, Inc. Mucosal tissue adhesion via textured surface
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
KR101236285B1 (ko) * 2010-04-30 2013-02-26 대한민국 실크 피브로인 펩타이드를 유효성분으로 포함하는 골 이식재
DK2569021T3 (en) * 2010-05-11 2017-04-10 Allergan Inc POROGENE COMPOSITIONS, PROCEDURES FOR MANUFACTURING AND APPLICATIONS
CN103200971B (zh) * 2010-08-30 2015-09-30 哈佛大学校长及研究员协会 复合层状材料、其制造方法及其应用
EP2611492A2 (de) 2010-09-03 2013-07-10 Tufts University/Trustees of Tufts College Mit plasmonischen nanopartikeln dotierte seidenstoffe
JP5754612B2 (ja) * 2010-10-06 2015-07-29 日立化成株式会社 創傷被覆材
US9993525B2 (en) 2011-02-28 2018-06-12 The Royal Institution For The Advancement Of Learning Biomaterial of chymotryptically isolated fraction of fibroin in a hydrogel
EP3884931A3 (de) 2012-02-06 2021-12-01 Children's Medical Center, Corp. Mehrschichtiges biomaterial zur geweberegenerierung und wundheilung
KR101374683B1 (ko) 2012-06-18 2014-03-17 대한민국 누에 유래 Ｄｐｐ 단백질을 포함하는 뼈 관련 질환 예방 및 개선용 식품 조성물
CN103028145B (zh) * 2012-10-24 2014-06-18 浙江大学 一种丝素蛋白基一体化骨软骨双层支架及其制备与应用
WO2014074804A2 (en) 2012-11-08 2014-05-15 Smith & Nephew, Inc. Methods and compositions suitable for improved reattachment of detached cartilage to subchondral bone
AU2013342257B2 (en) 2012-11-08 2018-08-30 Smith & Nephew, Inc. Improved reattachment of detached cartilage to subchondral bone
KR102457668B1 (ko) * 2013-03-15 2022-10-21 트러스티즈 오브 터프츠 칼리지 저분자량 실크 조성물 및 안정화 실크 조성물
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
KR20240025711A (ko) * 2013-09-30 2024-02-27 실크 테라퓨틱스, 인코퍼레이티드 실크 단백질 단편 조성물 및 이로부터 제작된 물품
DK3182985T3 (da) 2014-08-20 2020-04-06 Silk Tech Ltd Fibroinafledt proteinsammensætning
CN113564927A (zh) 2014-12-02 2021-10-29 丝绸医疗公司 丝性能服装和产品及其制备方法
WO2016115159A1 (en) * 2015-01-12 2016-07-21 Silk Therapeutics, Inc. Preserved silk protein fragment compositions and articles
EP3319475B1 (de) * 2015-07-06 2020-02-12 Mitchell Terrace Pty. Ltd. Vorrichtung zum auftragen eines kosmetikprodukts
US11512425B2 (en) * 2015-07-14 2022-11-29 Evolved By Nature, Inc. Silk performance apparel and products and methods of preparing the same
EP3432939A1 (de) * 2016-03-24 2019-01-30 Locate Therapeutics Limited Gerüstmaterial, verfahren und verwendungen
EP3496662A4 (de) 2016-08-12 2019-10-30 Silk Technologies Ltd. Aus seide gewonnenes protein zur behandlung von entzündungen
EP3642923A1 (de) * 2017-06-23 2020-04-29 Merck Patent GmbH Kabelgarnitur für hgü-kabel
WO2019067745A1 (en) 2017-09-27 2019-04-04 Silk, Inc. SILK-COATED FABRICS, PRODUCTS AND PREPARATION METHODS THEREFOR
CN108421086B (zh) * 2018-04-19 2020-11-03 济南羽时信息科技有限公司 一种纳米羟基磷灰石改性聚氨酯脲骨修复材料及其制备方法
US20200188178A1 (en) * 2018-12-18 2020-06-18 National Taiwan University Of Science And Technology Double-layer dressing containing silk fibroin and a method for making the same
CN113698630B (zh) * 2020-05-22 2023-07-25 中国科学院苏州纳米技术与纳米仿生研究所 一种可快速固化的双网络水凝胶及其制备方法与应用
WO2022120767A1 (zh) * 2020-12-10 2022-06-16 深圳先进技术研究院 一种有序多孔复合材料及其制备方法和应用
CN112933294A (zh) * 2021-03-05 2021-06-11 中国人民解放军总医院第四医学中心 一种可塑性骨水泥再生修复材料
CN115025287A (zh) * 2022-06-16 2022-09-09 上海市同济医院 一种用于子宫内膜修复的长效缓释细胞支架及其制备方法和应用
CN115837095B (zh) * 2022-12-21 2024-04-09 上海交通大学医学院附属第九人民医院 用于组织工程的支架及其在促进细胞分布中的应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5566929A (en) * 1978-11-13 1980-05-20 Kanebo Ltd Finely-powdered fibroin and its manufacture
JPS5640156A (en) * 1979-09-05 1981-04-16 Kanebo Ltd Porous membrane and its manufacture
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
JPS58184395A (ja) * 1982-04-22 1983-10-27 Teisan Kk 低温液化ガス定量流出装置
CH673117A5 (de) * 1986-12-10 1990-02-15 Ajinomoto Kk
JPS6434372A (en) * 1987-07-31 1989-02-03 Toa Nenryo Kogyo Kk Filler for bone depleted part and void part
JPH0694518B2 (ja) * 1987-11-02 1994-11-24 工業技術院長 絹フィブロイン多孔質体の製造方法
JPH01254164A (ja) * 1988-04-01 1989-10-11 Terumo Corp 傷口保護材およびその製造方法
JPH01254621A (ja) * 1988-04-01 1989-10-11 Terumo Corp 薬剤担体および徐放性薬剤ならびにそれらの製造方法
JPH01256350A (ja) * 1988-04-01 1989-10-12 Terumo Corp 絹フイブロインを用いた食品およびその製造方法
JPH01288269A (ja) * 1988-05-16 1989-11-20 Tonen Corp 複合化成形物
JP2507885B2 (ja) * 1988-06-06 1996-06-19 農林水産省蚕糸・昆虫農業技術研究所長 絹フィブロインハイドロゲル
EP0513803A2 (de) 1991-05-17 1992-11-19 Japan Vilene Company, Ltd. Träger zur Immobilisierung von Tierzellen und Verfahren zu seiner Herstellung und Verfahren zur Züchtung
US5480644A (en) * 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
JPH06292595A (ja) * 1993-04-05 1994-10-21 Kiyoshi Hirabayashi 低分子量フィブロインの製造方法
US6140452A (en) * 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
US5599852A (en) * 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
AU706434B2 (en) * 1994-10-18 1999-06-17 Ethicon Inc. Injectable liquid copolymers for soft tissue repair and augmentation
JPH08268905A (ja) * 1995-03-31 1996-10-15 Takayuki Nagashima コロイド状絹フィブロイン及びそれを含有する組成物
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
CA2164262A1 (en) * 1995-12-01 1997-06-02 Charles J. Doillon Biostable porous material comprising composite biopolymers
WO1997045532A1 (en) * 1996-05-28 1997-12-04 Brown University Research Foundation Hyaluronan based biodegradable scaffolds for tissue repair
US6218357B1 (en) 1996-08-15 2001-04-17 Seiji Terauchi Fibroin fluid and process for the production thereof
JP3537297B2 (ja) * 1996-08-15 2004-06-14 聖治 寺内 フィブロイン流動体及びその製造方法
JPH10215794A (ja) * 1997-02-12 1998-08-18 Tsuruokashi 無味白色ゲル状絹フィブロインを混入加工してなる柔弾性緻密構造の加工食品
JP2955653B2 (ja) * 1998-02-16 1999-10-04 農林水産省蚕糸・昆虫農業技術研究所長 絹蛋白質／コラーゲン複合体およびその製造方法
IT1309453B1 (it) 1999-10-01 2002-01-23 Consorzio Per Gli Studi Uni Substrato bioartificiale per la realizzazione di tessuti e organianimali, in particolare umani.
CN1235571C (zh) 1999-11-02 2006-01-11 武汉大学 壳聚糖与丝心蛋白共混微球及其用途和制备方法
IT1316885B1 (it) 2000-10-02 2003-05-13 Consorzio Per Gli Studi Uni Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta.
JP3412014B2 (ja) * 2000-12-19 2003-06-03 独立行政法人農業生物資源研究所 ハイドロゲルの製造方法および細胞培養支持体
JP3999667B2 (ja) * 2001-03-07 2007-10-31 株式会社キョウトバイオメディカルサイエンス 医療用のフィブロイン粉末及びフィブロイン水溶液
JP3989694B2 (ja) * 2001-05-02 2007-10-10 クラシエホームプロダクツ株式会社 ゲル状組成物及びその製造方法
JPWO2002102845A1 (ja) * 2001-06-14 2004-09-30 独立行政法人農業生物資源研究所 絹フィブロイン由来機能性ポリペプチドの製造法及びその利用

Also Published As

Publication number Publication date
WO2003035124A3 (en) 2003-09-12
US8071118B2 (en) 2011-12-06
US20120040907A1 (en) 2012-02-16
JP4669662B2 (ja) 2011-04-13
CA2466001A1 (en) 2003-05-01
CA2466001C (en) 2012-01-03
AU2002348072A1 (en) 2003-05-06
US20070190099A1 (en) 2007-08-16
WO2003035124A2 (en) 2003-05-01
ATE420671T1 (de) 2009-01-15
CN1277584C (zh) 2006-10-04
EP1446169B1 (de) 2009-01-14
CN1575188A (zh) 2005-02-02
JP2005510268A (ja) 2005-04-21
US7727542B2 (en) 2010-06-01
EP1446169A2 (de) 2004-08-18
US20030099630A1 (en) 2003-05-29
ES2321915T3 (es) 2009-06-15

Similar Documents

Publication Publication Date Title
DE60230907D1 (de) Fibroinzusammensetzungen und verfahren zu deren herstellung
Abdallah et al. Strategies for optimizing the soft tissue seal around osseointegrated implants
ATE262356T1 (de) Spritzbares knochenersatzmaterial enthaltend fibrin oder fibrinogen sowie hydroxylapatit zement
Brown et al. Cell responses to biomimetic protein scaffolds used in tissue repair and engineering
Zippel et al. Biomaterials and mesenchymal stem cells for regenerative medicine
KR100531922B1 (ko) 연골치료제 조성물 및 그 사용방법
ATE359836T1 (de) Poröse keramische komposit-knochenimplantate
MY139618A (en) Biodegradable polyurethane/urea compositions
DE60138817D1 (de) Biologisch aktives material
MX2009003737A (es) Composicion inyectable en deposito y su procedimiento de preparacion.
WO2005120595A3 (en) In situ hardening paste, its manufacture and use
WO2011137292A2 (en) Injectable, load-bearing cell/microbead/calcium phosphate bone paste for bone tissue engineering
ATE543509T1 (de) Material und verfahren zur förderung der reparatur von nervengewebe
ATE547134T1 (de) Dentalimplantat und verfahren zu dessen herstellung
ATE454910T1 (de) Zusammengesetzte strukturen mit hyaluronsäure und derivaten davon als neue knochensubstitute und transplantate
JP2011504406A5 (de)
WO2005020846A3 (en) Artificial bone and joint compositions and methods of use and manufacture
Yang et al. In vivo evaluation of bone‐bonding ability of RGD‐coated porous implant using layer‐by‐layer electrostatic self‐assembly
TheinHan et al. Non‐rigid calcium phosphate cement containing hydrogel microbeads and absorbable fibres seeded with umbilical cord stem cells for bone engineering
KR20190092059A (ko) 연골세포, 피브리노겐, 콜라겐 또는 트롬빈을 포함하는 관절경하 수술을 위한 연골 재생용 조성물
JP2008029746A (ja) 腱または靱帯固定用インターフェアランススクリュー、および、腱または靱帯固定セット
JPWO2005079728A1 (ja) 象牙質再生方法
JP2014111554A (ja) 口腔外科用骨再生材料
AU2018315622A1 (en) Multiphasic tissue scaffold constructs
WO2004045496A3 (en) Compositions and devices comprising or encoding the run x2 protein and method of use

Legal Events

Date Code Title Description
8364 No opposition during term of opposition