DE60210093D1 - Beta-amino-tetrahydroimidazo(1,2-a)pyrazine und -tetrahydrotriazolo(4,3-a)pyrazine als dipeptidyl peptidase inhibitoren zur behandlung oder prevention von diabetes - Google Patents

Beta-amino-tetrahydroimidazo(1,2-a)pyrazine und -tetrahydrotriazolo(4,3-a)pyrazine als dipeptidyl peptidase inhibitoren zur behandlung oder prevention von diabetes

Info

Publication number
DE60210093D1
DE60210093D1 DE60210093T DE60210093T DE60210093D1 DE 60210093 D1 DE60210093 D1 DE 60210093D1 DE 60210093 T DE60210093 T DE 60210093T DE 60210093 T DE60210093 T DE 60210093T DE 60210093 D1 DE60210093 D1 DE 60210093D1
Authority
DE
Germany
Prior art keywords
pyrazine
etrahydrotriazolo
tetrahydroimidazo
diabetes
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60210093T
Other languages
English (en)
Other versions
DE60210093T2 (de
Inventor
D Edmondson
H Fisher
Dooseop Kim
Malcolm Maccoss
R Parmee
E Weber
Jinyou Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60210093(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE60210093D1 publication Critical patent/DE60210093D1/de
Application granted granted Critical
Publication of DE60210093T2 publication Critical patent/DE60210093T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DE60210093T 2001-07-06 2002-07-05 Beta-amino-tetrahydroimidazo(1,2-a)pyrazine und -tetrahydrotriazolo(4,3-a)pyrazine als dipeptidyl peptidase inhibitoren zur behandlung oder prevention von diabetes Expired - Lifetime DE60210093T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
US303474P 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (2)

Publication Number Publication Date
DE60210093D1 true DE60210093D1 (de) 2006-05-11
DE60210093T2 DE60210093T2 (de) 2006-11-23

Family

ID=23172273

Family Applications (4)

Application Number Title Priority Date Filing Date
DE60210093T Expired - Lifetime DE60210093T2 (de) 2001-07-06 2002-07-05 Beta-amino-tetrahydroimidazo(1,2-a)pyrazine und -tetrahydrotriazolo(4,3-a)pyrazine als dipeptidyl peptidase inhibitoren zur behandlung oder prevention von diabetes
DE200712000056 Pending DE122007000056I1 (de) 2001-07-06 2002-07-05 Beta-amino-tetrahydroimidazo (1,2-A)pyrazine und-tetrahydrotriazolo(4,3-A)pyrazine als dipeptidyl peptidase Inhibitoren zur Behandlung oder preventionvon Diabetes
DE60236767T Expired - Lifetime DE60236767D1 (de) 2001-07-06 2002-07-05 Medizinische Verwendung eines TetrahydrotriazoloÄ4,3-aÜpyrazins
DE122008000046C Pending DE122008000046I1 (de) 2001-07-06 2002-07-05 Beta-amino-tetrahydroimidazo(1,2-a)pyrazine und -tetrahydrotriazolo(4,3-a)pyrazine als dipeptidyl peptidase inhibitoren zur behandlung oder prevention von diabetes

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE200712000056 Pending DE122007000056I1 (de) 2001-07-06 2002-07-05 Beta-amino-tetrahydroimidazo (1,2-A)pyrazine und-tetrahydrotriazolo(4,3-A)pyrazine als dipeptidyl peptidase Inhibitoren zur Behandlung oder preventionvon Diabetes
DE60236767T Expired - Lifetime DE60236767D1 (de) 2001-07-06 2002-07-05 Medizinische Verwendung eines TetrahydrotriazoloÄ4,3-aÜpyrazins
DE122008000046C Pending DE122008000046I1 (de) 2001-07-06 2002-07-05 Beta-amino-tetrahydroimidazo(1,2-a)pyrazine und -tetrahydrotriazolo(4,3-a)pyrazine als dipeptidyl peptidase inhibitoren zur behandlung oder prevention von diabetes

Country Status (46)

Country Link
US (9) US6699871B2 (de)
EP (4) EP1625847B1 (de)
JP (1) JP3762407B2 (de)
KR (1) KR100606871B1 (de)
CN (2) CN1290848C (de)
AR (1) AR036114A1 (de)
AT (2) ATE471148T1 (de)
AU (1) AU2002320303B2 (de)
BE (1) BE2007C047I2 (de)
BG (1) BG108493A (de)
BR (1) BRPI0210866B8 (de)
CA (1) CA2450740C (de)
CR (1) CR7235A (de)
CY (3) CY2007019I2 (de)
DE (4) DE60210093T2 (de)
DK (2) DK1625847T3 (de)
DO (1) DOP2002000438A (de)
EA (2) EA006845B1 (de)
EC (1) ECSP044935A (de)
ES (2) ES2259713T3 (de)
FR (2) FR07C0041I2 (de)
GE (2) GEP20053734B (de)
HK (1) HK1068882A1 (de)
HR (1) HRP20031098B1 (de)
HU (2) HU225695B1 (de)
IL (3) IL159109A0 (de)
IS (2) IS2218B (de)
JO (1) JO2230B1 (de)
LT (1) LTC1412357I2 (de)
LU (2) LUC91360I2 (de)
MA (1) MA27053A1 (de)
ME (1) ME00439B (de)
MX (1) MXPA04000018A (de)
MY (1) MY127961A (de)
NL (2) NL300287I2 (de)
NO (4) NO321999B1 (de)
NZ (1) NZ529833A (de)
PE (1) PE20030654A1 (de)
PL (1) PL196278B6 (de)
PT (2) PT1625847E (de)
RS (1) RS50737B (de)
SI (1) SI1412357T1 (de)
TW (1) TWI226331B (de)
UA (1) UA74912C2 (de)
WO (1) WO2003004498A1 (de)
ZA (1) ZA200309294B (de)

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