DE602005022378D1 - Lokale, vaskuläre Verabreichung von 2-methoxyestradiol in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen - Google Patents

Lokale, vaskuläre Verabreichung von 2-methoxyestradiol in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen

Info

Publication number: DE602005022378D1
Authority: DE; Germany
Prior art keywords: devices; agents; compounds; medical device; utilized
Prior art date: 2004-03-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

DE602005022378T

Other languages

English (en)

Inventor

Robert Falotico

Tom Jay Parry

Jonathon Z Zhao

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cordis Corp

Original Assignee

Cordis Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-22

Filing date

2005-03-21

Publication date

2010-09-02

2005-03-21 Application filed by Cordis Corp filed Critical Cordis Corp

2010-09-02 Publication of DE602005022378D1 publication Critical patent/DE602005022378D1/de

Status Active legal-status Critical Current

2025-03-22 Anticipated expiration legal-status Critical

Links

CQOQDQWUFQDJMK-SSTWWWIQSA-N 2-methoxy-17beta-estradiol Chemical compound C([C@@H]12)C[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]1CCC1=C2C=C(OC)C(O)=C1 CQOQDQWUFQDJMK-SSTWWWIQSA-N 0.000 title 1
208000024248 Vascular System injury Diseases 0.000 title 1
208000012339 Vascular injury Diseases 0.000 title 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
208000037803 restenosis Diseases 0.000 title 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
229960002930 sirolimus Drugs 0.000 title 1
230000002792 vascular Effects 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 5
229940124597 therapeutic agent Drugs 0.000 abstract 4
229940126585 therapeutic drug Drugs 0.000 abstract 4
239000000560 biocompatible material Substances 0.000 abstract 2
208000007536 Thrombosis Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000011248 coating agent Substances 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000010828 elution Methods 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers

DE602005022378T 2004-03-22 2005-03-21 Lokale, vaskuläre Verabreichung von 2-methoxyestradiol in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen Active DE602005022378D1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/805,736 US7875282B2 (en)	2004-03-22	2004-03-22	Coated medical device for local vascular delivery of Panzem® in combination with rapamycin to prevent restenosis following vascular injury

Publications (1)

Publication Number	Publication Date
DE602005022378D1 true DE602005022378D1 (de)	2010-09-02

Family

ID=34940609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602005022378T Active DE602005022378D1 (de)	2004-03-22	2005-03-21	Lokale, vaskuläre Verabreichung von 2-methoxyestradiol in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen

Country Status (8)

Country	Link
US (1)	US7875282B2 (de)
EP (1)	EP1588725B1 (de)
JP (1)	JP5052757B2 (de)
CN (2)	CN103170012B (de)
AT (1)	ATE474610T1 (de)
CA (1)	CA2499254C (de)
DE (1)	DE602005022378D1 (de)
ES (1)	ES2347443T3 (de)

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2004
- 2004-03-22 US US10/805,736 patent/US7875282B2/en not_active Expired - Fee Related
2005
- 2005-03-03 CA CA2499254A patent/CA2499254C/en active Active
- 2005-03-18 JP JP2005079900A patent/JP5052757B2/ja not_active Expired - Fee Related
- 2005-03-21 DE DE602005022378T patent/DE602005022378D1/de active Active
- 2005-03-21 ES ES05251712T patent/ES2347443T3/es active Active
- 2005-03-21 EP EP05251712A patent/EP1588725B1/de active Active
- 2005-03-21 AT AT05251712T patent/ATE474610T1/de not_active IP Right Cessation
- 2005-03-22 CN CN201210495692.2A patent/CN103170012B/zh not_active Expired - Fee Related
- 2005-03-22 CN CNA2005100560381A patent/CN1672746A/zh active Pending

Also Published As

Publication number	Publication date
EP1588725B1 (de)	2010-07-21
US7875282B2 (en)	2011-01-25
JP5052757B2 (ja)	2012-10-17
CN1672746A (zh)	2005-09-28
ATE474610T1 (de)	2010-08-15
US20050209688A1 (en)	2005-09-22
JP2005270658A (ja)	2005-10-06
CA2499254A1 (en)	2005-09-22
CN103170012A (zh)	2013-06-26
CN103170012B (zh)	2016-12-21
ES2347443T3 (es)	2010-10-29
EP1588725A1 (de)	2005-10-26
CA2499254C (en)	2014-01-28

Publication	Publication Date	Title
DE602005022378D1 (de)	2010-09-02	Lokale, vaskuläre Verabreichung von 2-methoxyestradiol in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen
ATE442169T1 (de)	2009-09-15	Lokale, vaskuläre verabreichung von cladribin in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen
ATE475438T1 (de)	2010-08-15	Lokale, vaskuläre verabreichung von etoposide in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen
EP2286848A3 (de)	2012-08-29	Lokale vaskuläre Abgabe von Mycophenolsäure in Kombination mit Rapamycin zur Verhinderung von Restenose
EP1582225A3 (de)	2008-06-04	Arzneimittelabgabevorrichtung
EP1568387A3 (de)	2006-01-25	Beschichtung mit strahlenschützender Verbindung für medizinische Geräte
EP1591108A3 (de)	2007-08-29	Formulierungen von Sirolimus und seine Analoge in Lösungsform zur Behandlung von koronaren Herzkrankheit
CA2490170A1 (en)	2005-06-19	Local vascular delivery of trichostatin a alone or in combination with sirolimus to prevent restenosis following vascular injury
EP1723976A3 (de)	2011-08-03	Therapeutische Mittel enthaltend intraluminale Instrumente
DE602005022645D1 (de)	2010-09-16	Implantierbare vaskuläre Vorrichtung zur Abgabe von Topotecan in Kombination mit Rapamycin
EP1586337A3 (de)	2008-03-19	Lokale Verabreichung einer Kombination von Rapamycin und 17 beta-Estradiol zur Behandlung von vulnerabler Plaque
CA2467797A1 (en)	2004-11-20	Increased biocompatibility of implantable medical devices
EP1974758A3 (de)	2010-11-03	Lokale, vaskuläre Versorgung von Probucol allein oder in Kombination mit Sirolimus zur Behandlung der Restenose, empfindlichem Plaque, AAA und Schlaganfall
EP1749545A3 (de)	2007-03-21	System zur Behandlung von Aneurysmen
US7906133B2 (en)	2011-03-15	Optimized dosing for drug coated stents
CA2462479A1 (en)	2004-09-30	Modified delivery device for coated medical devices
ATE339227T1 (de)	2006-10-15	Beschichtetes medizinsches implantat zur behandlung von gefässerkrankungen
ATE358505T1 (de)	2007-04-15	Beschichtete endovaskuläre vorrichtung
EP2042202A3 (de)	2012-11-21	Lokale vaskuläre Abgabe von mTOR-Inhibitoren in Kombination mit von Peroxisom-Proliferatoren aktivierten Rezeptorstimulatoren
MXPA03006825A (es)	2004-09-03	Dispositivos vasculares revestidos.
WO2006047378A3 (en)	2007-02-15	Biocompatible and hemocompatible amphiphilic coatings for drug deliver
US20040241211A9 (en)	2004-12-02	Devices and methods for reducing scar tissue formation
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