DE602005021541D1 - Verfahren zum formen einer mikronadel - Google Patents

Verfahren zum formen einer mikronadel

Info

Publication number
DE602005021541D1
DE602005021541D1 DE602005021541T DE602005021541T DE602005021541D1 DE 602005021541 D1 DE602005021541 D1 DE 602005021541D1 DE 602005021541 T DE602005021541 T DE 602005021541T DE 602005021541 T DE602005021541 T DE 602005021541T DE 602005021541 D1 DE602005021541 D1 DE 602005021541D1
Authority
DE
Germany
Prior art keywords
mold
mold apparatus
molding
micronadel
closed position
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005021541T
Other languages
English (en)
Inventor
Dennis E Ferguson
Satinder K Nayar
Donald L Pochardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of DE602005021541D1 publication Critical patent/DE602005021541D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B29C45/568—Applying vibrations to the mould parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B29C45/561—Injection-compression moulding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C2045/0094—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor injection moulding of small-sized articles, e.g. microarticles, ultra thin articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2791/00—Shaping characteristics in general
    • B29C2791/004—Shaping under special conditions
    • B29C2791/008—Using vibrations during moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/2669—Moulds with means for removing excess material, e.g. with overflow cavities
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/34—Moulds having venting means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
DE602005021541T 2004-12-07 2005-12-07 Verfahren zum formen einer mikronadel Active DE602005021541D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63431904P 2004-12-07 2004-12-07
PCT/US2005/044121 WO2006062974A2 (en) 2004-12-07 2005-12-07 Method of molding a microneedle

Publications (1)

Publication Number Publication Date
DE602005021541D1 true DE602005021541D1 (de) 2010-07-08

Family

ID=36168440

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005021541T Active DE602005021541D1 (de) 2004-12-07 2005-12-07 Verfahren zum formen einer mikronadel

Country Status (11)

Country Link
US (3) US8088321B2 (de)
EP (2) EP2067599B1 (de)
JP (1) JP2008522875A (de)
KR (1) KR20070098851A (de)
CN (2) CN102358015A (de)
AT (1) ATE468961T1 (de)
AU (1) AU2005314151B2 (de)
CA (1) CA2589733C (de)
DE (1) DE602005021541D1 (de)
IL (1) IL183556A (de)
WO (1) WO2006062974A2 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006055795A1 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Low-profile microneedle array applicator
CN102358015A (zh) * 2004-12-07 2012-02-22 3M创新有限公司 模制微型针的方法
WO2007112309A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007127976A2 (en) * 2006-05-01 2007-11-08 Georgia Tech Research Corporation Particle based molding
EP2444226A3 (de) 2007-06-20 2012-08-29 3M Innovative Properties Company Ultraschallspritzgiessen auf einer bahn
CN101340784A (zh) * 2007-07-04 2009-01-07 深圳富泰宏精密工业有限公司 电子装置机壳及其制造方法
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
CN105999538A (zh) 2008-11-18 2016-10-12 3M创新有限公司 空心微针阵列和方法
CN102458559B (zh) 2009-04-10 2014-06-04 3M创新有限公司 制造中空微针阵列的方法以及由其制得的制品和用途
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
CN102985131B (zh) 2010-04-28 2016-06-29 金伯利-克拉克环球有限公司 用于递送siRNA的医疗装置
AU2011246879C1 (en) 2010-04-28 2016-03-24 Sorrento Therapeutics, Inc. Device for delivery of rheumatoid arthritis medication
AU2011311255B2 (en) 2010-04-28 2015-10-08 Sorrento Therapeutics, Inc. Method for increasing permeability of an epithelial barrier
AU2011288209C1 (en) * 2010-04-28 2016-03-24 Kimberly-Clark Worldwide, Inc. Injection molded microneedle array and method for forming the microneedle array
EP2563454A4 (de) * 2010-04-28 2014-01-22 Kimberly Clark Co Injektionsgeformtes mikronadel-array und verfahren zur formung des mikronadel-arrays
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
DK2646218T3 (en) * 2010-12-02 2016-07-25 3M Innovative Properties Co MICROCANYLS OF LIQUID CRYSTALLINE POLYMER
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
MX338255B (es) 2011-03-15 2016-04-11 3M Innovative Properties Co Modelo asistido por ultrasonido de articulos conformados de manera precisa y metodos.
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
BR112014009712A2 (pt) 2011-10-27 2017-04-18 Kimberly Clark Co dispositivos implantáveis para a administração de agentes bioativos
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
WO2013061208A1 (en) 2011-10-27 2013-05-02 Kimberly-Clark Worldwide, Inc. Transdermal delivery of high viscosity bioactive agents
US10155332B2 (en) * 2011-12-09 2018-12-18 National Taiwan University Of Science And Technology In-mold vibratile injection compression molding method and molding apparatus thereof
CN103301092B (zh) 2012-03-06 2014-12-03 中国科学院理化技术研究所 聚合物微针阵列芯片及其制备方法和应用
MX370579B (es) 2012-05-01 2019-12-17 Univ Pittsburgh Commonwealth Sys Higher Education Arreglos de microagujas cargadas en la punta para insercion transdermica.
US8663537B2 (en) 2012-05-18 2014-03-04 3M Innovative Properties Company Injection molding apparatus and method
WO2014105458A1 (en) 2012-12-27 2014-07-03 3M Innovative Properties Company Article with hollow microneedles and method of making
SG11201509810TA (en) 2013-05-31 2015-12-30 3M Innovative Properties Co Microneedle injection and infusion apparatus and method of using same
CN105246541B (zh) 2013-05-31 2018-01-16 3M创新有限公司 包括双覆盖件的微针注射设备
CN105283216B (zh) 2013-05-31 2018-01-26 3M创新有限公司 包括倒置致动器的微针注入设备
US10232157B2 (en) 2013-07-16 2019-03-19 3M Innovative Properties Company Hollow microneedle with beveled tip
US10384047B2 (en) 2013-07-16 2019-08-20 3M Innovative Properties Company Hollow microneedle with bevel opening
WO2015009531A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Article comprising a microneedle
EP3021931B1 (de) 2013-07-16 2021-09-01 Kindeva Drug Delivery L.P. Hohlmikronadelfeldartikel
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
CN107073249B (zh) * 2014-10-17 2021-01-01 花王株式会社 微细中空突起物的制造方法
WO2016118459A1 (en) 2015-01-21 2016-07-28 3M Innovative Properties Company Microneedle array and method of use
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2017131397A (ja) * 2016-01-27 2017-08-03 花王株式会社 微細中空突起具の製造方法
KR101747099B1 (ko) * 2016-02-11 2017-06-14 권영덕 생체적합성 고분자를 이용한 마이크로니들의 제조방법
JP6626403B2 (ja) * 2016-05-10 2019-12-25 富士フイルム株式会社 凹状パターンを有するモールドの作製方法、及びパターンシートの製造方法
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
WO2018211421A1 (en) * 2017-05-19 2018-11-22 Sabic Global Technologies B.V. Methods and systems of producing polymer microneedle arrays via ultrasonic embossing, and resulting microneedle arrays
US11766809B2 (en) * 2018-03-05 2023-09-26 Bae Systems Plc Method of forming pre-defined recess in cured or cast explosive composition
EP3778169B1 (de) * 2018-03-27 2021-12-29 FUJIFILM Corporation Verfahren zur herstellung einer form mit konkavem sockelmuster und verfahren zur herstellung einer musterfolie
US20210228119A1 (en) 2018-05-16 2021-07-29 Kindeva Drug Delivery L.P. Microneedle biosensor
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
EP3698841A1 (de) * 2019-02-19 2020-08-26 L'oreal Injektionsvorrichtung
MX2021011100A (es) * 2019-03-15 2022-01-19 Celanese Int Corp Proceso para reducir el rubor de la puerta y diseño de molde para la misma.
JP6618647B1 (ja) 2019-04-26 2019-12-11 三光化成株式会社 微細パターン転写用モールド及び微細パターン成形方法
DE102019122648B4 (de) * 2019-08-22 2021-04-29 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
EP4048152B1 (de) 2020-07-29 2023-12-20 Biolinq Incorporated System zur kontinuierlichen analytüberwachung mit einer mikronadelanordnung
CN112454809A (zh) * 2020-09-27 2021-03-09 鹰潭荣嘉集团医疗器械实业有限公司 一种输液器注塑成型装置及方法
KR20220065661A (ko) * 2020-11-13 2022-05-20 주식회사 대웅테라퓨틱스 마이크로니들 어레이 및 이의 제조방법
US11389632B2 (en) 2020-12-21 2022-07-19 Mediccene Inc. Intradermal drug delivery device
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
US11857344B2 (en) 2021-05-08 2024-01-02 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
CA3226577A1 (en) 2021-07-07 2023-01-12 The Regents Of The University Of California Wearable, non-intrusive microneedle sensor
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
CN114260351B (zh) * 2021-12-23 2024-01-26 哈尔滨工业大学 一种大面积阵列微结构跨尺度模压成形装置和方法
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
TWI817854B (zh) * 2022-11-29 2023-10-01 淡江大學學校財團法人淡江大學 微針模具組及使用其製造微針貼片的方法

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US275400A (en) * 1883-04-10 Running-gear for vehicles
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US4381963A (en) * 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
JPS6058010B2 (ja) 1981-04-14 1985-12-18 三井化学株式会社 射出圧縮成形方法
US4515543A (en) * 1983-09-02 1985-05-07 The Budd Co. In-mold coating part ejection system
US4793954A (en) * 1987-08-17 1988-12-27 The B. F. Goodrich Company Shear processing thermoplastics in the presence of ultrasonic vibration
JPH01182016A (ja) * 1988-01-16 1989-07-19 Etsuhisa Abe プラスチック射出成形方法
JPH01218813A (ja) * 1988-02-29 1989-09-01 Komatsu Ltd プラスチックの成形方法
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
JP3131620B2 (ja) * 1990-11-12 2001-02-05 株式会社不二越 射出圧縮成形法
US5160823A (en) * 1991-01-03 1992-11-03 Hutchinson Technology, Inc. Moving mask laser imaging
US5141677A (en) * 1991-01-22 1992-08-25 Minnesota Mining And Manufacturing Company Method of hot stamping intraocular lens bodies
US5152917B1 (en) * 1991-02-06 1998-01-13 Minnesota Mining & Mfg Structured abrasive article
US5256360A (en) * 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
DE4222856C1 (de) * 1992-07-11 1993-05-27 Buerkert Gmbh
US5376317A (en) 1992-12-08 1994-12-27 Galic Maus Ventures Precision surface-replicating thermoplastic injection molding method and apparatus, using a heating phase and a cooling phase in each molding cycle
ATE182502T1 (de) 1993-09-13 1999-08-15 Minnesota Mining & Mfg Schleifartikel, verfahren zur herstellung desselben, verfahren zur verwendung desselben zum endbearbeiten, und herstellungswerkzeug
FR2720003B1 (fr) * 1994-05-23 1998-06-26 Samsung Electro Mech Dispositif servant à inciser la peau pour une médication transcutanée.
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
AU3758595A (en) 1994-09-30 1996-04-26 Rutgers, The State University Direct introduction of foreign materials into cells
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5645977A (en) * 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
WO1998011937A1 (en) * 1996-09-17 1998-03-26 Deka Products Limited Partnership System for delivery of drugs by transport
US6021559A (en) * 1996-11-01 2000-02-08 3M Innovative Properties Company Methods of making a cube corner article master mold
US6248281B1 (en) * 1996-11-14 2001-06-19 Idemitsu Petrochemical Co., Ltd. Compression apparatus for molding, injection compression molding machine, and injection compression molding method using the compression device
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
CN1206004C (zh) * 1997-12-11 2005-06-15 阿尔扎有限公司 增强透皮物剂流量的装置
ATE221400T1 (de) * 1997-12-11 2002-08-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
CN1315877A (zh) * 1998-08-31 2001-10-03 强生消费者公司 含刀片的电传送装置
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
ATE256484T1 (de) * 1999-01-28 2004-01-15 Cyto Pulse Sciences Inc Einbringen von makromolekülen in zellen
AR022471A1 (es) 1999-02-02 2002-09-04 Ortho Mcneil Pharm Inc Metodo para la fabricacion de matrices transdermicas
US6306331B1 (en) * 1999-03-24 2001-10-23 International Business Machines Corporation Ultra mold for encapsulating very thin packages
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6361733B1 (en) * 1999-09-22 2002-03-26 Delphi Technologies, Inc. Ultrasonic injection molding
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6551849B1 (en) * 1999-11-02 2003-04-22 Christopher J. Kenney Method for fabricating arrays of micro-needles
AU3081601A (en) * 1999-11-15 2001-05-30 Velcro Industries B.V. Skin attachment member
US6511463B1 (en) * 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
WO2001093930A1 (en) * 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
ES2717656T3 (es) * 2000-11-30 2019-06-24 Valeritas Inc Dispositivo con microsonda amovible sustancialmente libre sobre el alojamiento
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) * 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
AU2002312315A1 (en) * 2001-06-08 2002-12-23 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
BR0210628A (pt) * 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
AU2002327675A1 (en) * 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CA2500453A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
CN100387318C (zh) * 2001-10-31 2008-05-14 中国科学院电工研究所 透过皮肤给药的微型针阵列片及其制造方法
US7195872B2 (en) * 2001-11-09 2007-03-27 3D Biosurfaces, Inc. High surface area substrates for microarrays and methods to make same
EP1485317A2 (de) * 2001-11-30 2004-12-15 Alza Corporation Verfahren und vorrichtungen zur herstellung von mikroprojektoranordnungen
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US20030215816A1 (en) 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
AU2003251831B2 (en) * 2002-07-19 2009-06-11 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
NL1021421C2 (nl) 2002-09-10 2004-03-11 Fountain Patents B V Inrichting en werkwijze voor het vervaardigen van producten uit een warm plastische massa.
JP2004114552A (ja) * 2002-09-27 2004-04-15 Mitsuboshi Belting Ltd 針状体の製造方法および針状体
DE10246942A1 (de) * 2002-10-08 2004-04-22 Battenfeld Gmbh Vorrichtung zum Erzeugen von Mikrostrukturen
KR100563330B1 (ko) * 2003-01-16 2006-03-22 포스트마이크로 주식회사 Ｌｉｇａ공정을 이용한 폴리머 재질의 미세 바늘 어레이제조방법
DE10325260A1 (de) 2003-06-03 2004-12-30 Gauss, Ralph Kunststoffeinspritzeinheit durch Doppelnadel
WO2005000382A2 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
AR044985A1 (es) * 2003-07-02 2005-10-12 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US20050106226A1 (en) * 2003-10-24 2005-05-19 Cormier Michel J. Pretreatment method and system for enhancing transdermal drug delivery
WO2005051455A2 (en) 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
CN102358015A (zh) * 2004-12-07 2012-02-22 3M创新有限公司 模制微型针的方法
EP1968777B1 (de) * 2005-12-23 2013-11-06 3M Innovative Properties Company Herstellung von mikronadelanordnungen

Also Published As

Publication number Publication date
EP1824655B1 (de) 2010-05-26
ATE468961T1 (de) 2010-06-15
JP2008522875A (ja) 2008-07-03
EP2067599A3 (de) 2010-01-27
EP2067599B1 (de) 2016-10-26
IL183556A (en) 2011-11-30
AU2005314151B2 (en) 2011-09-08
US20120280428A1 (en) 2012-11-08
WO2006062974A2 (en) 2006-06-15
US20110163479A1 (en) 2011-07-07
AU2005314151A1 (en) 2006-06-15
CN101072668B (zh) 2011-08-31
US20080088066A1 (en) 2008-04-17
US8246893B2 (en) 2012-08-21
CN102358015A (zh) 2012-02-22
CA2589733C (en) 2014-02-11
US8821779B2 (en) 2014-09-02
CA2589733A1 (en) 2006-06-15
CN101072668A (zh) 2007-11-14
US8088321B2 (en) 2012-01-03
WO2006062974A3 (en) 2006-09-28
IL183556A0 (en) 2007-09-20
EP1824655A2 (de) 2007-08-29
EP2067599A2 (de) 2009-06-10
KR20070098851A (ko) 2007-10-05

Similar Documents

Publication Publication Date Title
DE602005021541D1 (de) Verfahren zum formen einer mikronadel
AU2003275819A8 (en) Molded part removing apparatus and method for an injection molding machine
JP2008522875A5 (de)
DE10195634T1 (de) Formgebungsvorrichtung und Verfahren unter Verwendung eines Roboters, um einen Einsatz in eine Form einzuführen
HK1113109A1 (en) Injection molding apparatus having separation type mold and controlling method thereof
DE59107836D1 (de) Verfahren und Vorrichtung zum Herstellen eines Kunststofformteils
DE602004020825D1 (de) Form zum Einsatzformen und Verfahren zum Formen eines hohlen Bauteils
TW200602183A (en) Method and apparatus for vibrating melt in an injection molding machine using active material elements
DE60304238D1 (de) Mit langen Glasfasern verstärktes zum Verformen geeignetes Harzmaterial, Verfahren zum Formen eines geformten Gegenstandes, und ein mit diesem Verfahren geformter Gegenstand
ATE411151T1 (de) Verfahren zum herstellen eines behälters mit einem datenträger und behälter mit einem datenträger
DE10123277B8 (de) Verfahren und Vorrichtung zum elektromagnetischen Schließen, Zuhalten und Öffnen von Formen einer Spritzgießmaschine
ATE446179T1 (de) Verbessertes verfahren zum laden eines formsatzes in eine formmaschine
DE69812996D1 (de) Entgasungsvorrichtung, entlüftete form und verfahren zum herstellen eines geformten gegenstands
ATE524289T1 (de) Entformstation
ATE470550T1 (de) SPRITZGIEßANORDNUNG UND VERFAHREN ZUM ANSPRITZEN EINES FORMTEILS UND VERWENDUNG EINER SPRITZGIEßANORDNUNG
DE69937165D1 (de) Verfahren und Vorrichtung zum Aufbringen einer Dekorfolie durch Spritzgiessen
DE69710375D1 (de) Vorrichtung und verfahren zum blasformen von zwei thermoplastischen folien unter verwendung von pneumatischen verschiebbaren membranen zum schliessen der formhälften
ATE54598T1 (de) Verfahren und vorrichtung zum herstellen von formteilen aus thermoplastichem kunststoff, insbesondere ungereinigten und unsortierten kunststoffabfaellen.
ATE241458T1 (de) Spritzgiessvorrichtung zum hinterspritzen eines obermaterials mit kunststoff und verfahren
ATE551668T1 (de) Verfahren zur herstellung einer entität und entsprechende vorrichtung
DE60109084D1 (de) Verfahren und Vorrichtung zum Spritzformen mit Einlegeteilen
GB0010708D0 (en) Method and apparatus for injection moulding plastics material
SE0200195D0 (sv) Förfarande och anordning för framställning av plastdetaljer
WO2005058574A3 (de) Verfahren zum herstellen von spritzgussteilen, spritzgussvorrichtung zur durchführung des verfahrens sowie nach dem verfahren hergestelltes spritzgussteil
DE10393492D2 (de) Vorrichtung zum Ausgleichen von beim Spritzprägen auftretenden Kippkräften und Verfahren zum Herstellen von Kunststoff-Formteilen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition