DE60124095D1 - Verfahren zur inaktivierung von mikroorganismen unter verwendung von photosensibilisatoren - Google Patents

Verfahren zur inaktivierung von mikroorganismen unter verwendung von photosensibilisatoren

Info

Publication number
DE60124095D1
DE60124095D1 DE60124095T DE60124095T DE60124095D1 DE 60124095 D1 DE60124095 D1 DE 60124095D1 DE 60124095 T DE60124095 T DE 60124095T DE 60124095 T DE60124095 T DE 60124095T DE 60124095 D1 DE60124095 D1 DE 60124095D1
Authority
DE
Germany
Prior art keywords
fluid
photosensitizer
microorganisms
photosensibilizers
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60124095T
Other languages
English (en)
Other versions
DE60124095T2 (de
Inventor
Paul Goodrich
Dennis Hlavinka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo BCT Biotechnologies LLC
Original Assignee
Gambro Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gambro Inc filed Critical Gambro Inc
Publication of DE60124095D1 publication Critical patent/DE60124095D1/de
Application granted granted Critical
Publication of DE60124095T2 publication Critical patent/DE60124095T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029Radiation
    • A61L2/0076Radiation using a photocatalyst or photosensitiser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088Liquid substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08Radiation
    • A61L2/10Ultra-violet radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/22Blood or products thereof
DE60124095T 2000-06-15 2001-06-08 Verfahren zur inaktivierung von mikroorganismen unter verwendung von photosensibilisatoren Expired - Lifetime DE60124095T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US596429 1996-02-02
US09/596,429 US7094378B1 (en) 2000-06-15 2000-06-15 Method and apparatus for inactivation of biological contaminants using photosensitizers
PCT/US2001/018752 WO2001096340A1 (en) 2000-06-15 2001-06-08 Method for inactivation of microorganisms using photosensitizers

Publications (2)

Publication Number Publication Date
DE60124095D1 true DE60124095D1 (de) 2006-12-07
DE60124095T2 DE60124095T2 (de) 2007-06-06

Family

ID=24387230

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60124095T Expired - Lifetime DE60124095T2 (de) 2000-06-15 2001-06-08 Verfahren zur inaktivierung von mikroorganismen unter verwendung von photosensibilisatoren

Country Status (7)

Country Link
US (1) US7094378B1 (de)
EP (1) EP1289991B1 (de)
AT (1) ATE343579T1 (de)
AU (1) AU2001266829A1 (de)
CA (1) CA2381594C (de)
DE (1) DE60124095T2 (de)
WO (1) WO2001096340A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498156B2 (en) * 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US7186543B1 (en) * 1998-07-21 2007-03-06 Gambro Inc. Preparation of vaccines using a photosensitizer and light
US9044523B2 (en) * 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US6548241B1 (en) * 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
US7381976B2 (en) * 2001-03-13 2008-06-03 Triton Thalassic Technologies, Inc. Monochromatic fluid treatment systems
US20030141260A1 (en) * 2001-12-28 2003-07-31 Frank Corbin Oxygen-enhanced pathogen inactivation
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) * 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
CA2474448C (en) * 2002-02-01 2010-09-07 Gambro, Inc. Inactivation of west nile virus and malaria using photosensitizers
DE60327166D1 (de) * 2002-02-01 2009-05-28 Caridianbct Biotechnologies Ll Reduzierung von verunreinigungen in blut und blutprodukten durch verwendung von photoaktiven substanzen und bestrahlung mit licht eines engen wellelängenbereichs
WO2003066109A1 (en) * 2002-02-08 2003-08-14 Gambro, Inc. Nitric oxide in a pathogen inactivation process
EP1496947A1 (de) 2002-04-24 2005-01-19 Gambro, Inc. Entfernung von adenin in einem verfahren zur keimreduzierung von blut und blutkomponenten
JP2005524714A (ja) * 2002-05-06 2005-08-18 ガンブロ  インコーポレーテッド ミトコンドリアのエンハンサーを使用する、細胞性の血液成分に対するダメージを防止し、または若返らせる方法。
US8296071B2 (en) 2004-03-15 2012-10-23 Terumo Bct Biotechnologies, Llc Methods for uniformly treating biological samples with electromagnetic radiation
EP1767225A1 (de) * 2005-09-21 2007-03-28 Insense Limited Methode zur Stabilisierung einer Proteinlösung durch Zugabe von Quenchern von Hydroxylradikalen und deren Sterilisierung mit ionisierender Strahlung
US20070102858A1 (en) * 2005-11-07 2007-05-10 Navigant Biotechnologies, Inc. Clamps and methods for displacing fluid from portions of fluid containers
CA2629340A1 (en) * 2005-12-06 2007-06-14 Navigant Biotechnologies, Llc Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
DE102005062410A1 (de) 2005-12-23 2007-08-09 Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. Verfahren zur Bestrahlung von Thrombozytenkonzentraten in flexiblen Behältnissen mit ultraviolettem Licht
DE102005062634A1 (de) 2005-12-23 2007-06-28 Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung
KR101357484B1 (ko) * 2006-01-27 2014-02-03 테루모 비씨티 바이오테크놀로지스, 엘엘씨 고농축 알록사진 용액의 제조 방법 및 조성물
CA2657621A1 (en) 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
EP1902740A1 (de) 2006-09-19 2008-03-26 Maco Pharma S.A. Blutbeutelsystem und Verfahren, um Pathogene in Blutplättchenkonzentraten mit Hilfe des Blutbeutelsystems zu neutralisieren
US20080234670A1 (en) * 2007-03-15 2008-09-25 Rogers C Brian System and apparatus providing a controlled light source for medicinal applications
EP2008669A1 (de) 2007-06-22 2008-12-31 Maco Pharma S.A. Bestrahlungsvorrichtung zur Deaktivierung von Krankheitserregern und/oder Leukozyten in einer biologischen Flüssigkeit und entsprechendes Verfahren
CN101868255A (zh) * 2007-08-01 2010-10-20 科安比司特生物技术有限责任公司 全血的病原体灭活
WO2009026073A1 (en) * 2007-08-22 2009-02-26 Caridianbct Biotechnologies, Llc Prevention of transfusion related acute lung injury using riboflavin and light
LT5567B (lt) 2008-08-06 2009-04-27 Vilniaus Universitetas Maisto ir su maistu susietų paviršių nukenksminimo būdas
US9005530B2 (en) * 2009-07-09 2015-04-14 Donald Nevin Compressor with an internal disinfecting UV light source
US9694128B1 (en) * 2010-02-24 2017-07-04 Brian LeBerthon Device and method for administering an anti-cancer substance
US20140083628A1 (en) 2012-09-27 2014-03-27 Velico Medical, Inc. Spray drier assembly for automated spray drying
EP2683415B1 (de) 2011-03-11 2017-06-14 Deutsches Rheuma-Forschungszentrum Berlin Desinfektionsmodul für durchflusszytometer
US8940228B2 (en) 2012-01-11 2015-01-27 Terumo Bct, Inc. Slidable clamp for port isolation
WO2014018103A1 (en) 2012-07-26 2014-01-30 Brezinski Donna J Portable phototherapy device
US20150360048A1 (en) * 2013-02-07 2015-12-17 Rocomp Global, Llc Electromagnetic radiation targeting devices, assemblies, systems and methods
US9227005B2 (en) 2013-03-14 2016-01-05 Brian J LeBerthon Method and device for treating cancer
US9561184B2 (en) 2014-09-19 2017-02-07 Velico Medical, Inc. Methods and systems for multi-stage drying of plasma
IT202000016864A1 (it) * 2020-07-10 2022-01-10 Emoled S R L Metodo per la inattivazione di una colonia di patogeni in spazi, superfici o oggetti usando radiazione elettromagnetica
EP3939618A1 (de) 2020-07-10 2022-01-19 Emoled Srl Verfahren zur inaktivierung von krankheitserregerkolonie in räumen, auf oberflächen und objekten mittels elektromagnetischer strahlung
CN113414049B (zh) * 2021-06-04 2023-04-18 圣托马斯先进材料公司 一种智能雾化器及其使用方法
CN114225067B (zh) * 2021-12-22 2024-01-26 中国医学科学院输血研究所 一种血液病原体灭活方法
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US683690A (en) 1900-06-13 1901-10-01 Charles M Johnson Apparatus for sterilizing disease-germs.
US1733239A (en) 1929-01-31 1929-10-29 Donald E Roberts Applicator for conducting ultra-violet rays
US1961700A (en) 1932-07-29 1934-06-05 Gen Electric Vapor Lamp Co Apparatus for sterilizing articles by ultraviolet radiation
US2056614A (en) 1933-06-13 1936-10-06 Gen Electric Vapor Lamp Co Ultraviolet sterilizer
US2111491A (en) 1935-01-26 1938-03-15 Winthrop Chem Co Inc Process of preparing phosphoric acid esters of hydroxyalkyl isoalloxazines
US2212330A (en) 1938-05-03 1940-08-20 Albert G Thomas Sterilizing device
US2212230A (en) 1938-05-28 1940-08-20 Internat Telephone Dev Co Inc Airplane guiding beacon
US2340890A (en) 1941-02-25 1944-02-08 Lang Alphonse Method and apparatus for sterilizing, preserving, and irradiating of various liquid substances
US2340980A (en) 1942-08-14 1944-02-08 Mexican American Hat Company Sweatband structure
US2654735A (en) 1949-07-29 1953-10-06 Us Vitamin Corp Process for the production of derivatives of 9-polyhydroxyalkylisoalloxazines and products obtained
US2825729A (en) 1955-05-24 1958-03-04 Upjohn Co Isoalloxazines
US3189598A (en) 1960-01-14 1965-06-15 Yagi Kunio Fatty acid esters of riboflavin
US3456053A (en) 1966-05-06 1969-07-15 Pfizer & Co C Inactivated hog cholera virus vaccine
US3683183A (en) 1969-06-04 1972-08-08 Radiation Machinery Corp A flow-through irradiator for the extra corporeal irradiation of fluid
US3705985A (en) 1969-06-27 1972-12-12 Nuclear Associates Inc Fluid irradiator and process for its manufacture
US3683177A (en) 1970-06-30 1972-08-08 Louis P Veloz Sterilization of a fluid by ultraviolet radiation
US3852032A (en) 1971-06-07 1974-12-03 Uroptics Int Inc Process for sterilizing hydrophilic gelatin lenses having ultraviolet stabilizers
US3776694A (en) 1972-04-04 1973-12-04 L Leittl Germicidal toiletry cabinet for different personal hygiene items
US3926556A (en) 1973-05-30 1975-12-16 Raymond Marcel Gut Boucher Biocidal electromagnetic synergistic process
US3864081A (en) 1973-06-12 1975-02-04 Spectroderm International Inc Apparatus for sterilizing biologic material and the like by ultra-violet irradiation
US3920650A (en) 1973-09-19 1975-11-18 Morton Norwich Products Inc Isoalloxazines
US3894236A (en) 1973-12-10 1975-07-08 Wayne K Hazelrigg Device for irradiating fluids
US3927325A (en) 1974-07-10 1975-12-16 Us Energy Tissue irradiator
US4139348A (en) 1975-11-28 1979-02-13 Massachusetts Institute Of Technology Electrochemical process and apparatus to control the chemical state of a material
US4305390A (en) 1975-11-28 1981-12-15 Massachusetts Institute Of Technology Method for generating oxygen in an excited electronic state and inactivation of microorganisms
US4181128A (en) 1975-11-28 1980-01-01 Massachusetts Institute Of Technology Virus inactivation applicator and the like
US4173631A (en) 1976-08-23 1979-11-06 Merck & Co., Inc. 7-Methyl-8-methylamino-10-(1'-D-ribityl)isoalloxazine
US4169204A (en) 1976-10-20 1979-09-25 Regents Of The University Of California Psoralens
US4124598A (en) 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
US4196281A (en) 1976-10-20 1980-04-01 Regents Of The University Of California Psoralens
US4424201A (en) 1978-11-28 1984-01-03 Rockefeller University Employment of a mereyanine dye for the detection of malignant leukocytic cells
IT1166343B (it) 1979-08-20 1987-04-29 Francarosa Baccichetti Furocumarina per la fotochemioterapia della fsoriasi e di altre malattie cutanee ad essa sensibili
US4321918A (en) 1979-10-23 1982-03-30 Clark Ii William T Process for suppressing immunity to transplants
US4321919A (en) 1979-12-11 1982-03-30 Leukocyte Research, Inc. Method and system for externally treating human blood
US4398906A (en) 1979-12-11 1983-08-16 Frederic A. Bourke, Jr. Method for externally treating the blood
US4428744A (en) 1979-12-11 1984-01-31 Frederic A. Bourke, Jr. Method and system for externally treating the blood
DE8007265U1 (de) 1980-03-17 1981-08-27 ESPE Fabrik pharmazeutischer Präparate GmbH, 8031 Seefeld Geraet zum behandeln von zahnersatzteilen
US4336809A (en) 1980-03-17 1982-06-29 Burleigh Instruments, Inc. Human and animal tissue photoradiation system and method
US4481167A (en) 1980-04-11 1984-11-06 The Dow Chemical Company Sanitizing complexes of polyoxazolines or polyoxazines and polyhalide anions
US4398031A (en) 1980-06-11 1983-08-09 The Regents Of The University Of California Coumarin derivatives and method for synthesizing 5'-methyl psoralens therefrom
JPS616899Y2 (de) 1981-04-27 1986-03-03
US4464166A (en) 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US4612007A (en) 1981-06-16 1986-09-16 Edelson Richard Leslie Method and system for externally treating the blood
US4614190A (en) 1981-09-08 1986-09-30 Alexei Stanco Photoradiation method and arrangement
US4467206A (en) 1981-12-14 1984-08-21 Extracorporeal Medical Specialties, Inc. Method and apparatus for the irradiation of fluids
US4456512A (en) 1982-03-10 1984-06-26 The Dow Chemical Company Photochemical reactor and method
US4649151A (en) 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
CA1216518A (en) 1982-11-01 1987-01-13 Gail A. Rock Plasma-free medium for platelet storage
US4684521A (en) 1982-12-08 1987-08-04 Frederic A. Bourke, Jr. Method and system for externally treating the blood
US4613322A (en) 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
US4683889A (en) 1983-03-29 1987-08-04 Frederic A. Bourke, Jr. Method and system for externally treating the blood
US4727027A (en) 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4748120A (en) 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4946438A (en) 1983-09-01 1990-08-07 The Trustees Of Columbia University In The City Of New York Process for development of acceptance of transplanted organs and tissues
US4861704A (en) 1983-09-01 1989-08-29 The Trustees Of Columbia University In The City Of New York Processes for development of acceptance of transplanted organs and tissues
US4992363A (en) 1983-11-09 1991-02-12 Thomas Jefferson University Method for preparing glucose free media for storing blood platelets
US4693981A (en) 1983-12-20 1987-09-15 Advanced Genetics Research Institute Preparation of inactivated viral vaccines
US4604356A (en) 1983-12-21 1986-08-05 Miles Laboratories, Inc. Purification of flavin adenine dinucleotide synthetase
CH657864A5 (de) 1984-02-17 1986-09-30 Ciba Geigy Ag Wasserloesliche phthalocyaninverbindungen und deren verwendung als photoaktivatoren.
US4493981A (en) 1984-03-05 1985-01-15 General Electric Company Boil dry protection system for cooking appliance
JPH0622222B2 (ja) 1984-09-18 1994-03-23 株式会社東芝 光処理装置
JPS6176160A (ja) 1984-09-21 1986-04-18 松永 是 殺細胞方法
US4576143A (en) 1984-10-05 1986-03-18 Clark Iii William T Method of immune modification by means of extracorporeal irradiation of the blood
US4596547A (en) 1984-10-29 1986-06-24 Mcneilab, Inc. Valve apparatus for photoactivation patient treatment system
US4573960A (en) 1984-10-29 1986-03-04 Extracorporeal Medical Specialties, Inc. Three phase irradiation treatment process
US4578056A (en) 1984-10-29 1986-03-25 Extracorporeal Medical Specialties, Inc. Patient photopheresis treatment apparatus and method
US4623328A (en) 1984-10-29 1986-11-18 Mcneilab, Inc. Pump monitor for photoactivation patient treatment system
US4737140A (en) 1984-10-29 1988-04-12 Mcneilab, Inc. Irradiation chamber for photoactivation patient treatment system
US4573962A (en) 1984-10-29 1986-03-04 Extracorporeal Medical Specialties, Inc. Cassette drawer assembly for photoactivation patient treatment system
US4568328A (en) 1984-10-29 1986-02-04 Extracorporeal Medical Specialties, Inc. Automated photophoresis blood portion control methods and apparatus
US4708715A (en) 1984-10-29 1987-11-24 Mcneilab, Inc. Light array assembly for photoactivation patient treatment system
US4573961A (en) 1984-10-29 1986-03-04 Extracorporeal Medical Specialties, Inc. Electronic control methods for puvapheresis apparatus
US4608255A (en) 1985-01-31 1986-08-26 American National Red Cross Biocompatible method for in situ production of functional platelets and product produced thereby lacking immunogenicity
DD249143A3 (de) 1985-03-20 1987-09-02 Ilmenau Tech Hochschule Vorrichtung zur physiologisch-therapeutisch wirksamen optischen bestrahlung koerpereigenen venenblutes
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4651739A (en) 1985-04-08 1987-03-24 The General Hospital Corporation Light-induced killing of carcinoma cells
US4998931A (en) 1985-07-05 1991-03-12 Puget Sound Blood Center Method of reducing immunogenicity and inducing immunologic tolerance
US4930516B1 (en) 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US4695460A (en) 1986-03-19 1987-09-22 American Red Cross Synthetic, plasma-free, transfusible platelet storage medium
US4961928A (en) 1986-03-19 1990-10-09 American Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
US4866282A (en) 1986-08-26 1989-09-12 Baxter International Inc. Irradiation of blood products
US4726949A (en) 1986-08-26 1988-02-23 Baxter Travenol Laboratories, Inc. Irradiation of blood products
US4952812A (en) 1986-08-26 1990-08-28 Baxter International Inc. Irradiation of blood products
US4775625A (en) 1986-11-21 1988-10-04 The Medical College Of Wisconsin, Inc. Inactivating enveloped viruses with a merocyanine dye
US4915683A (en) 1986-11-21 1990-04-10 The Medical College Of Wisconsin, Inc. Antiviral method, agents and apparatus
US4878891A (en) 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
US4833165A (en) 1987-10-07 1989-05-23 Louderback Allan Lee Method of inactivating HTLV-III virus in blood
US4880788A (en) 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
DE3805459A1 (de) 1988-02-22 1989-08-31 Biotest Pharma Gmbh Verfahren zur sterilisation von blut, plasma, blut- und plasmaderivaten, zellsuspensionen oder dgl.
DE3824647A1 (de) 1988-07-20 1990-02-01 Wedeco Entkeimungsanlagen Vorrichtung zur bestrahlung von medien mittels uv-licht
EP0386241A4 (en) 1988-08-23 1990-10-03 Radiotech Inst An Light-guiding device for medical treatment
US4994367A (en) 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
US4950665A (en) 1988-10-28 1990-08-21 Oklahoma Medical Research Foundation Phototherapy using methylene blue
US4960408A (en) 1989-01-10 1990-10-02 Klainer Albert S Treatment methods and vaccines for stimulating an immunological response against retroviruses
US4921473A (en) 1989-02-02 1990-05-01 Therakos, Inc. Multicomponent fluid separation and irradiation system
US4978688A (en) 1989-03-24 1990-12-18 Louderback Allan Lee Method of treating white blood cells
US4999375A (en) 1989-04-11 1991-03-12 Hoffmann-La Roche Inc. Psoralen reagent compositions for extracorporeal treatment of blood
US6187572B1 (en) * 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
EP0544895B1 (de) * 1991-06-21 1997-08-27 Baxter International Inc. Verfahren zur inaktivierung von pathogenen in einer körperflüssigkeit
US6235508B1 (en) * 1995-06-07 2001-05-22 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US6277337B1 (en) * 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US6258577B1 (en) * 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US6268120B1 (en) * 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US6548241B1 (en) * 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants

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US7094378B1 (en) 2006-08-22
DE60124095T2 (de) 2007-06-06
CA2381594A1 (en) 2001-12-20
EP1289991B1 (de) 2006-10-25
AU2001266829A1 (en) 2001-12-24
EP1289991A1 (de) 2003-03-12
CA2381594C (en) 2009-03-24
WO2001096340A1 (en) 2001-12-20
ATE343579T1 (de) 2006-11-15

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