DE60104686D1 - Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf haut - Google Patents

Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf haut

Info

Publication number
DE60104686D1
DE60104686D1 DE60104686T DE60104686T DE60104686D1 DE 60104686 D1 DE60104686 D1 DE 60104686D1 DE 60104686 T DE60104686 T DE 60104686T DE 60104686 T DE60104686 T DE 60104686T DE 60104686 D1 DE60104686 D1 DE 60104686D1
Authority
DE
Germany
Prior art keywords
skin
application
applicator
grinding surface
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60104686T
Other languages
English (en)
Other versions
DE60104686T2 (de
Inventor
A Mikszta
M Brittingham
Jason Alarcon
J Pettis
P Dekker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of DE60104686D1 publication Critical patent/DE60104686D1/de
Application granted granted Critical
Publication of DE60104686T2 publication Critical patent/DE60104686T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
DE60104686T 2000-05-22 2001-05-18 Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf haut Expired - Lifetime DE60104686T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US576643 2000-05-22
US09/576,643 US6595947B1 (en) 2000-05-22 2000-05-22 Topical delivery of vaccines
PCT/US2001/016121 WO2001089622A1 (en) 2000-05-22 2001-05-18 Applicator having abrading surface coated with substance to be applied to skin

Publications (2)

Publication Number Publication Date
DE60104686D1 true DE60104686D1 (de) 2004-09-09
DE60104686T2 DE60104686T2 (de) 2005-08-11

Family

ID=24305324

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60104686T Expired - Lifetime DE60104686T2 (de) 2000-05-22 2001-05-18 Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf haut

Country Status (12)

Country Link
US (3) US6595947B1 (de)
EP (1) EP1289599B1 (de)
JP (1) JP4801309B2 (de)
CN (1) CN100394995C (de)
AT (1) ATE272423T1 (de)
AU (2) AU6175701A (de)
BR (1) BR0111345B1 (de)
CA (1) CA2410561C (de)
DE (1) DE60104686T2 (de)
ES (1) ES2222376T3 (de)
MX (1) MXPA02011557A (de)
WO (1) WO2001089622A1 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6743215B2 (en) * 2001-04-06 2004-06-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and cellulite reduction
CA2457804C (en) * 2001-08-13 2012-10-16 University Of Rochester Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles
FR2828648A1 (fr) * 2001-08-16 2003-02-21 Adam Bouaziz Constitution d'un vaccin extractible a partir d'un insert immunogene.
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
CA2497154C (en) * 2002-08-29 2012-01-03 Becton, Dickinson And Company Substance delivery via a rotating microabrading surface
CN1723053A (zh) * 2002-09-12 2006-01-18 儿童医院医疗中心 无痛药物注射的方法和设备
ATE503491T1 (de) * 2003-02-13 2011-04-15 Becton Dickinson Co Verbesserte anthraximpfstoffe und abgabeverfahren
WO2005020912A2 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
US20050095283A1 (en) * 2003-09-16 2005-05-05 Aphios Corporation Compositions and methods for topically treating diseases
JP2007509704A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン 経皮的ワクチン送達のための系および方法
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
US7670314B2 (en) * 2004-02-17 2010-03-02 Children's Hospital Medical Center Injection device for administering a vaccine
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
KR20060135931A (ko) * 2004-04-01 2006-12-29 알자 코포레이션 인플루엔자 백신의 경피전달 장치 및 방법
BRPI0509897A (pt) * 2004-04-13 2007-08-07 Alza Corp aparelho e método para distribuição transdérmica de múltiplas vacinas
ES2650188T3 (es) * 2004-06-10 2018-01-17 3M Innovative Properties Company Dispositivo y kit de aplicación de parches
US20070292445A1 (en) * 2004-07-06 2007-12-20 Transpharma Medical Ltd. Delivery system for transdermal immunization
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
AU2005306426B2 (en) * 2004-11-18 2011-04-28 3M Innovative Properties Company Masking method for coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006055795A1 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Low-profile microneedle array applicator
EP2388078B1 (de) 2004-11-18 2013-03-20 3M Innovative Properties Co. Verfahren zum Kontaktbeschichten einer Mikronadelanordnung
ATE504328T1 (de) 2004-11-18 2011-04-15 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
ATE468961T1 (de) * 2004-12-07 2010-06-15 3M Innovative Properties Co Verfahren zum formen einer mikronadel
JP5301985B2 (ja) 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー ツールフィードバック感知のためのシステム及び方法
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US20080195035A1 (en) 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
EP2474338B1 (de) 2005-06-27 2013-07-24 3M Innovative Properties Company Vorrichtung zum Aufbringen einer Mikronadelanordnung
WO2007002522A1 (en) 2005-06-27 2007-01-04 3M Innovative Properties Company Microneedle cartridge assembly and method of applying
US20070009542A1 (en) * 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
US20070088248A1 (en) * 2005-09-02 2007-04-19 Iomai Corporation Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
EP1962942A1 (de) * 2005-12-21 2008-09-03 3M Innovative Properties Company Mikronadelvorrichtungen
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
EP2069013A2 (de) 2006-10-02 2009-06-17 Emkinetics, Inc. Verfahren und vorrichtung für magnetische induktionstherapie
US20090054333A1 (en) * 2006-10-17 2009-02-26 Antonio Giordano Peptide inhibitors of cyclin-dependent kinase activity and uses thereof
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
EP2166965B1 (de) 2007-07-17 2017-05-17 Neal Marc Lonky Vorrichtung zur transepithelialen gewebedisruption und -sammlung
US8795197B2 (en) * 2007-07-17 2014-08-05 Histologics, LLC Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response
WO2009047774A2 (en) * 2007-10-09 2009-04-16 Transpharma Ltd. Magnetic patch coupling
CN101969873B (zh) 2007-12-05 2015-05-13 赛诺龙医疗公司 一次性电磁能施用器以及使用它的方法
AU2009205297A1 (en) 2008-01-17 2009-07-23 Syneron Medical Ltd. A hair removal apparatus for personal use and the method of using same
EP2237732A4 (de) 2008-01-24 2011-06-01 Syneron Medical Ltd Vorrichtung, apparatur und verfahren zur fettgewebebehandlung
ES2412783T3 (es) 2008-09-21 2013-07-12 Syneron Medical Ltd. Un método y aparato para el tratamiento personal de la piel
US8691502B2 (en) 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
JP2013508119A (ja) 2009-10-26 2013-03-07 エムキネティクス， インコーポレイテッド 神経、筋肉および身体組織の電磁刺激のための方法および装置
US9044213B1 (en) 2010-03-26 2015-06-02 Histologics, LLC Frictional tissue sampling and collection method and device
GB201007207D0 (en) 2010-04-29 2010-06-16 Univ Cork Method
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
CA2871770C (en) 2012-05-01 2020-07-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US10201332B1 (en) 2012-12-03 2019-02-12 Healoe Llc Device and method of orienting a biopsy device on epithelial tissue
US20140297784A1 (en) * 2013-03-29 2014-10-02 Lucy Ma Zhao Cross Platform Application Transactions
MX2016009771A (es) 2014-01-31 2016-11-14 Factor Bioscience Inc Metodos y productos para la produccion y administracion de acido nucleico.
WO2016131052A1 (en) 2015-02-13 2016-08-18 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US11013466B2 (en) 2016-01-28 2021-05-25 Healoe, Llc Device and method to control and manipulate a catheter
WO2018035377A1 (en) 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
EP3600100A4 (de) 2017-03-27 2021-01-06 Novoxel Ltd. System, vorrichtung und verfahren zur intradermalen abgabe einer lösung
DE102017126501A1 (de) 2017-11-10 2019-05-16 Lts Lohmann Therapie-Systeme Ag Mikronadelsystem zur Applikation eines Hepatitis-Impfstoffes
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3289670A (en) * 1964-03-09 1966-12-06 Milo Bundy Corp Device for abrading and applying biologicals to the skin of a patient
US3351059A (en) * 1964-06-02 1967-11-07 Norman Lettvin Single stable dose vaccinator
US3556080A (en) * 1968-04-08 1971-01-19 Lincoln Lab Inc Skin allergy testing device
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4270548A (en) * 1979-09-05 1981-06-02 Aller-Screen, Inc. Allergy testing method
US4483348A (en) 1982-03-25 1984-11-20 Nathan Sher Skin testing device
GB2125280B (en) 1982-08-18 1986-01-02 Hyman Goldberg Surgical scrubbing device
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
AU614092B2 (en) 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
CA2008262A1 (en) * 1989-01-30 1990-07-30 John A. Gilly Clinical applicator
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
SU1724181A1 (ru) 1990-03-22 1992-04-07 Ивано-Франковский Государственный Медицинский Институт Устройство дл камерно-скарификационного тестировани кожи
TW279133B (de) * 1990-12-13 1996-06-21 Elan Med Tech
DE4117900A1 (de) 1991-05-31 1992-12-03 Spantec Werkzeugtechnik Gmbh Walzenstirnfraeser
US5620896A (en) * 1992-03-23 1997-04-15 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5273528A (en) * 1992-07-10 1993-12-28 Skeen Mikell L Livestock inoculator
DE4307869C2 (de) * 1993-03-12 1996-04-04 Microparts Gmbh Mikrostrukturkörper und Verfahren zu deren Herstellung
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5380337A (en) * 1994-01-24 1995-01-10 Romaine; Richard A. Mesh-type skin biopsy appliance
US5660680A (en) 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
CA2149943C (en) * 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
WO1996007369A1 (en) 1994-09-05 1996-03-14 Cyanamid Websters Pty. Limited Scratch vaccine applicator and/or method of applying a vaccine
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
JPH0910307A (ja) * 1995-06-30 1997-01-14 Pentel Kk 注射器用ホルダ−
US5958589A (en) 1995-07-07 1999-09-28 The United States Of America As Represented By The Secretary Of Agriculture Starch-based microcellular foams
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
GB9520209D0 (en) 1995-09-25 1995-12-06 Cawley R Skin cleaning apparatus
US6032060A (en) * 1996-01-25 2000-02-29 3M Innovative Properties Company Method for conditioning skin and an electrode by passing electrical energy
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
CA2253549C (en) 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US5919364A (en) * 1996-06-24 1999-07-06 Regents Of The University Of California Microfabricated filter and shell constructed with a permeable membrane
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
EP0934093B1 (de) 1996-09-17 2003-01-15 Deka Products Limited Partnership System zur medikamentenabgabe durch transport
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US5910306A (en) * 1996-11-14 1999-06-08 The United States Of America As Represented By The Secretary Of The Army Transdermal delivery system for antigen
WO1998032526A1 (en) 1997-01-24 1998-07-30 The Regents Of The University Of California Apparatus and method for planar laminar mixing
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US5931794A (en) 1997-10-21 1999-08-03 Pitesky; Isadore Allergy testing apparatus
IL122016A (en) * 1997-10-22 2001-09-13 Tav Tech Ltd Apparatus for dermal abrasion
WO1999029364A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
AU3311599A (en) 1998-02-25 1999-09-15 Iomai Corporation Use of skin penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response induced by adp-ribosylating exotoxin
US5970998A (en) 1998-02-27 1999-10-26 The Regents Of The University Of California Microfabricated cantilever ratchet valve, and method for using same
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US6494865B1 (en) * 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
ATE295200T1 (de) * 1999-12-10 2005-05-15 Alza Corp Hautbehandlungsvorrichtung zur verlängerten transdermalen verabreichung von medikamenten

Also Published As

Publication number Publication date
CN1430526A (zh) 2003-07-16
US7731968B2 (en) 2010-06-08
WO2001089622A1 (en) 2001-11-29
ES2222376T3 (es) 2005-02-01
EP1289599B1 (de) 2004-08-04
EP1289599A1 (de) 2003-03-12
BR0111345B1 (pt) 2010-10-05
CA2410561C (en) 2009-05-12
CA2410561A1 (en) 2001-11-29
ATE272423T1 (de) 2004-08-15
AU2001261757B2 (en) 2004-04-01
JP4801309B2 (ja) 2011-10-26
JP2003534065A (ja) 2003-11-18
DE60104686T2 (de) 2005-08-11
MXPA02011557A (es) 2004-09-06
CN100394995C (zh) 2008-06-18
AU6175701A (en) 2001-12-03
US20030191085A1 (en) 2003-10-09
BR0111345A (pt) 2004-02-03
US6595947B1 (en) 2003-07-22
US20080009785A1 (en) 2008-01-10

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