DE60038183D1 - Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe - Google Patents
Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffeInfo
- Publication number
- DE60038183D1 DE60038183D1 DE60038183T DE60038183T DE60038183D1 DE 60038183 D1 DE60038183 D1 DE 60038183D1 DE 60038183 T DE60038183 T DE 60038183T DE 60038183 T DE60038183 T DE 60038183T DE 60038183 D1 DE60038183 D1 DE 60038183D1
- Authority
- DE
- Germany
- Prior art keywords
- delivery
- compositions
- compounds
- active agents
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17121399P | 1999-12-16 | 1999-12-16 | |
| US171213P | 1999-12-16 | ||
| PCT/US2000/034329 WO2001044199A1 (en) | 1999-12-16 | 2000-12-18 | Compounds and compositions for delivering active agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60038183D1 true DE60038183D1 (de) | 2008-04-10 |
| DE60038183T2 DE60038183T2 (de) | 2009-02-19 |
Family
ID=22622945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60038183T Expired - Lifetime DE60038183T2 (de) | 1999-12-16 | 2000-12-18 | Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6693208B2 (de) |
| EP (1) | EP1237872B1 (de) |
| JP (1) | JP4850379B2 (de) |
| AT (1) | ATE387430T1 (de) |
| AU (1) | AU2274201A (de) |
| DE (1) | DE60038183T2 (de) |
| ES (1) | ES2298168T3 (de) |
| WO (1) | WO2001044199A1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6344213B1 (en) * | 1996-03-29 | 2002-02-05 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6221367B1 (en) * | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
| US6916489B2 (en) * | 1992-06-15 | 2005-07-12 | Emisphere Technologies, Inc. | Active agent transport systems |
| US6461643B2 (en) | 1993-04-22 | 2002-10-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| NZ509410A (en) * | 1998-08-07 | 2003-08-29 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| ATE387430T1 (de) * | 1999-12-16 | 2008-03-15 | Emisphere Tech Inc | Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe |
| US7151191B2 (en) * | 2000-01-13 | 2006-12-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| WO2002002509A1 (en) * | 2000-06-29 | 2002-01-10 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6673574B2 (en) * | 2000-11-30 | 2004-01-06 | Unigene Laboratories Inc. | Oral delivery of peptides using enzyme-cleavable membrane translocators |
| US7700775B2 (en) | 2001-03-01 | 2010-04-20 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| AU2002254082B2 (en) * | 2001-03-01 | 2007-05-24 | Emisphere Technologies, Inc. | Compositions for delivering bisphosphonates |
| EP1461031B1 (de) | 2001-11-29 | 2016-06-29 | Emisphere Technologies, Inc. | Formulierungen zur oralen verabreichung von cromolyn-natrium |
| KR101165431B1 (ko) | 2002-02-20 | 2012-07-12 | 에미스페어 테크놀로지스, 인코포레이티드 | Ｇｌｐ-1 분자의 투여 방법 |
| US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| BR0318454A (pt) | 2003-08-08 | 2006-09-12 | Abgenix Inc | anticorpos dirigidos a hormÈnio da paratireóide (pth) e seus usos |
| US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| WO2005019184A1 (en) | 2003-08-20 | 2005-03-03 | Eli Lilly And Company | Compounds, methods and formulations for the oral delivery of a glucagon like peptide (glp)-1 compound or an melanocortin 4 receptor (mc4) agonist peptide |
| CA2530983C (en) | 2003-08-20 | 2012-09-25 | Eli Lilly And Company | Compounds, methods and formulations for the oral delivery of a glucagon like peptide (glp)-1 compound or an melanocortin 4 receptor (mc4) agonist peptide |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| JP2005209106A (ja) * | 2004-01-26 | 2005-08-04 | Nec Corp | 携帯通信端末、受信メール管理方法、プログラムおよび記録媒体 |
| US8039018B2 (en) * | 2004-05-06 | 2011-10-18 | Emisphere Technologies, Inc. | Solid dosage form of wetted heparin |
| RU2530889C2 (ru) * | 2004-05-14 | 2014-10-20 | Эмисфире Текнолоджис, Инк. | Соединения и составы для доставки активных веществ |
| NZ551196A (en) | 2004-05-14 | 2010-08-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| AU2005249410A1 (en) | 2004-05-14 | 2005-12-15 | Emisphere Technologies, Inc. | Aryl ketone compounds and compositions for delivering active agents |
| US9498487B2 (en) | 2004-05-19 | 2016-11-22 | Emisphere Technologies, Inc. | Topical cromolyn formulations |
| BRPI0510820A (pt) | 2004-05-19 | 2007-11-27 | Emisphere Tech Inc | composição farmacêutica, forma unitária de dosagem e seus usos |
| EP1773376A4 (de) | 2004-08-03 | 2009-07-01 | Emisphere Tech Inc | Antidiabetische orale insulinbiguanidkombination |
| AU2005286774A1 (en) * | 2004-09-17 | 2006-03-30 | Comentis, Inc | Amino-containing compounds which inhibit memapsin 2 beta-secretase activity and methods of use thereof |
| CA2580238A1 (en) * | 2004-09-17 | 2006-03-30 | Comentis, Inc. | Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof |
| NZ556373A (en) | 2004-12-29 | 2010-01-29 | Emisphere Tech Inc | Pharmaceutical formulations of gallium salts |
| WO2006076692A1 (en) * | 2005-01-12 | 2006-07-20 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
| JP2008535863A (ja) * | 2005-04-08 | 2008-09-04 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害する化合物およびその使用方法 |
| US8975227B2 (en) | 2005-07-15 | 2015-03-10 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
| US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| US8771712B2 (en) | 2006-05-09 | 2014-07-08 | Emisphere Technologies, Inc. | Topical administration of acyclovir |
| EP2040718B1 (de) * | 2006-06-28 | 2017-12-27 | Emisphere Technologies, Inc. | Galliumnitrid-formulierungen |
| CA2662853C (en) * | 2006-08-31 | 2016-07-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| WO2008112706A1 (en) | 2007-03-13 | 2008-09-18 | Nutrition 21, Inc. | Methods and compositions for the sustained release of chromium |
| WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
| EP2178837A2 (de) * | 2007-07-26 | 2010-04-28 | Comentis, Inc. | Isophthalamidderivate als hemmer der beta-sekretase-aktivität |
| MX2010002938A (es) * | 2007-09-24 | 2010-04-01 | Comentis Inc | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
| EP2461803B1 (de) | 2009-08-03 | 2018-10-17 | Emisphere Technologies, Inc. | Schnell wirkende naproxenzusammensetzung mit reduzierter wirkung auf magen und darm |
| EP2531202A4 (de) * | 2010-02-04 | 2013-07-17 | Lowell C Parsons | Verwendung oraler heparinpräparate zur behandlung von krankheiten und leiden im harntrakt |
| KR101836957B1 (ko) | 2011-03-01 | 2018-03-09 | 제이디에스 테라퓨틱스, 엘엘씨 | 당뇨병, 저혈당 및 관련 장애를 치료 및 예방하기 위한 인슐린과 크롬을 포함하는 조성물 |
| RU2657749C2 (ru) | 2012-09-21 | 2018-06-15 | Интенсити Терапьютикс, Инк | Способы лечения рака |
| AU2017217466A1 (en) | 2016-02-11 | 2018-08-23 | Nutrition 21, Llc | Chromium containing compositions for improving health and fitness |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3795739A (en) | 1972-02-14 | 1974-03-05 | Hoffmann La Roche | Treatment of parkinson disease |
| US3939253A (en) | 1973-11-02 | 1976-02-17 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease |
| US4061466A (en) | 1974-10-16 | 1977-12-06 | Ingvar Gosta Holger Sjoholm | Biologically active composition and the use thereof |
| DE2500157C2 (de) | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
| US4035507A (en) | 1975-04-17 | 1977-07-12 | Interx Research Corporation | Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease |
| DE2517229A1 (de) | 1975-04-18 | 1976-10-28 | Boehringer Mannheim Gmbh | Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung |
| DE2532420A1 (de) | 1975-07-19 | 1977-02-03 | Boehringer Mannheim Gmbh | Phenylessigsaeure-derivate und verfahren zu ihrer herstellung |
| CA1077842A (en) | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
| FR2374910A1 (fr) | 1976-10-23 | 1978-07-21 | Choay Sa | Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations |
| NZ196349A (en) | 1980-03-07 | 1984-08-24 | Interx Research Corp | Enhancement of absorption rate of orally administered polar bioactive agents |
| US4442090A (en) | 1980-11-09 | 1984-04-10 | Kyoto Yakuhin Kogyo Kabushiki Kaisha | Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use |
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| GB2092136B (en) | 1981-01-17 | 1985-06-05 | Mitsui Toatsu Chemicals | Production of n-substituted amide compounds |
| CA1188987A (en) | 1981-03-06 | 1985-06-18 | Masataka Morishita | Preparation having excellent absorption property |
| JPS58140026A (ja) | 1982-01-14 | 1983-08-19 | Toyo Jozo Co Ltd | 吸収性良好な製剤 |
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| DE3331009A1 (de) | 1983-08-27 | 1985-03-14 | Basf Ag, 6700 Ludwigshafen | Verfahren zur erhoehung der enteralen resorbierbarkeit von heparin bzw. heparinoiden sowie das so erhaeltliche heparin- bzw. heparinoidpraeparat |
| US4692433A (en) | 1983-10-12 | 1987-09-08 | The Regents Of The University Of California | Method and composition for regulating serum calcium levels of mammals |
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| US4689182A (en) | 1985-12-20 | 1987-08-25 | Warner-Lambert Company | Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity |
| LU86258A1 (fr) | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
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| FR2636238B1 (fr) | 1988-09-14 | 1994-01-21 | Morelle Jean | Nouvelles compositions antisudorales |
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| US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
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| US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5939381A (en) | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5990166A (en) | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
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| US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5863944A (en) | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| NZ509410A (en) * | 1998-08-07 | 2003-08-29 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| CA2358463A1 (en) * | 1999-01-08 | 2000-07-13 | Virginia Commonwealth University | Polymeric delivery agents and delivery agent compounds |
| ATE387430T1 (de) * | 1999-12-16 | 2008-03-15 | Emisphere Tech Inc | Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe |
-
2000
- 2000-12-18 AT AT00986516T patent/ATE387430T1/de not_active IP Right Cessation
- 2000-12-18 WO PCT/US2000/034329 patent/WO2001044199A1/en active IP Right Grant
- 2000-12-18 DE DE60038183T patent/DE60038183T2/de not_active Expired - Lifetime
- 2000-12-18 ES ES00986516T patent/ES2298168T3/es not_active Expired - Lifetime
- 2000-12-18 JP JP2001544689A patent/JP4850379B2/ja not_active Expired - Fee Related
- 2000-12-18 AU AU22742/01A patent/AU2274201A/en not_active Abandoned
- 2000-12-18 US US10/168,275 patent/US6693208B2/en not_active Expired - Lifetime
- 2000-12-18 EP EP00986516A patent/EP1237872B1/de not_active Expired - Lifetime
-
2003
- 2003-12-31 US US10/750,138 patent/US20050042274A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030216589A1 (en) | 2003-11-20 |
| WO2001044199A1 (en) | 2001-06-21 |
| ES2298168T3 (es) | 2008-05-16 |
| US20050042274A1 (en) | 2005-02-24 |
| US6693208B2 (en) | 2004-02-17 |
| ATE387430T1 (de) | 2008-03-15 |
| JP4850379B2 (ja) | 2012-01-11 |
| EP1237872B1 (de) | 2008-02-27 |
| EP1237872A4 (de) | 2005-06-15 |
| JP2003516971A (ja) | 2003-05-20 |
| DE60038183T2 (de) | 2009-02-19 |
| AU2274201A (en) | 2001-06-25 |
| EP1237872A1 (de) | 2002-09-11 |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: EMISPHERE TECHNOLOGIES, INC., CEDAR KNOLLS, N., US |