DE60027458D1 - Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren - Google Patents

Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren

Info

Publication number
DE60027458D1
DE60027458D1 DE60027458T DE60027458T DE60027458D1 DE 60027458 D1 DE60027458 D1 DE 60027458D1 DE 60027458 T DE60027458 T DE 60027458T DE 60027458 T DE60027458 T DE 60027458T DE 60027458 D1 DE60027458 D1 DE 60027458D1
Authority
DE
Germany
Prior art keywords
drug
release
reservoirs
substrate
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60027458T
Other languages
English (en)
Other versions
DE60027458T2 (de
Inventor
Amy C Richards
T Santini
J Cima
S Langer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE60027458D1 publication Critical patent/DE60027458D1/de
Publication of DE60027458T2 publication Critical patent/DE60027458T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
DE60027458T 1999-12-10 2000-12-01 Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren Expired - Lifetime DE60027458T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17021899P 1999-12-10 1999-12-10
US170218P 1999-12-10
PCT/US2000/042478 WO2001041736A2 (en) 1999-12-10 2000-12-01 Microchip devices for delivery of molecules and methods of fabrication thereof

Publications (2)

Publication Number Publication Date
DE60027458D1 true DE60027458D1 (de) 2006-05-24
DE60027458T2 DE60027458T2 (de) 2007-07-05

Family

ID=22619035

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027458T Expired - Lifetime DE60027458T2 (de) 1999-12-10 2000-12-01 Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren

Country Status (8)

Country Link
US (3) US6808522B2 (de)
EP (1) EP1235560B1 (de)
JP (1) JP2003516343A (de)
AT (1) ATE323470T1 (de)
AU (2) AU782639B2 (de)
CA (1) CA2393603C (de)
DE (1) DE60027458T2 (de)
WO (1) WO2001041736A2 (de)

Families Citing this family (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US6527762B1 (en) * 1999-08-18 2003-03-04 Microchips, Inc. Thermally-activated microchip chemical delivery devices
EP1229901B1 (de) * 1999-11-17 2009-03-18 Boston Scientific Limited Miniaturisierte vorrichtungen zur abgabe von molekülen in einer trägerflüssigkeit
ATE323470T1 (de) * 1999-12-10 2006-05-15 Massachusetts Inst Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
ATE499988T1 (de) * 2000-03-02 2011-03-15 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
EP1339312B1 (de) * 2000-10-10 2006-01-04 Microchips, Inc. Mikrochip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
DE10100961B4 (de) * 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
US6973718B2 (en) 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
AU2002326304A1 (en) 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
ATE285756T1 (de) 2001-06-28 2005-01-15 Microchips Inc Verfahren zum hermetischen versiegeln von mikrochip-reservoir-vorrichtungen
US7354597B2 (en) * 2001-12-03 2008-04-08 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
FI113383B (fi) * 2002-05-15 2004-04-15 Metso Field Systems Oy Viira
US6975902B2 (en) * 2002-06-28 2005-12-13 Alza Corporation Reservoir and a series of related reservoirs for use in an electrotransport drug delivery device and devices comprised thereof
US6953455B2 (en) * 2002-07-30 2005-10-11 Hospira, Inc. Medicine delivery system
WO2004071487A2 (en) * 2002-08-16 2004-08-26 Microchips, Inc. Controlled release device and method
WO2004022033A1 (en) * 2002-09-04 2004-03-18 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
WO2004026281A2 (en) * 2002-09-23 2004-04-01 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
EP1551499A1 (de) * 2002-10-04 2005-07-13 Microchips, Inc. Medizinische vorrichtung zur nervenstimulation und kontrollierten verabreichung von medikamenten
DE60331455D1 (de) * 2002-10-04 2010-04-08 Microchips Inc Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
IL152629A (en) * 2002-11-04 2010-12-30 Innoventions Ltd Implantable medical device for controlled release of a substance
US6929945B2 (en) 2002-12-09 2005-08-16 Advanced Fluidix Laboratories Llc Male fertility assay method and device
US20040247671A1 (en) * 2003-04-25 2004-12-09 Prescott James H. Solid drug formulation and device for storage and controlled delivery thereof
US20040220531A1 (en) * 2003-05-01 2004-11-04 Bui Tuan S. System and method operating microreservoirs delivering medication in coordination with a pump delivering diluent
WO2005010240A2 (en) * 2003-07-17 2005-02-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US7612443B1 (en) 2003-09-04 2009-11-03 University Of Notre Dame Du Lac Inter-chip communication
US20050107742A1 (en) * 2003-09-15 2005-05-19 The Regents Of The University Of Michigan Shatter-resistant microprobes
WO2005041767A2 (en) 2003-11-03 2005-05-12 Microchips, Inc. Medical device for sensing glucose
US20070036835A1 (en) * 2004-07-19 2007-02-15 Microchips, Inc. Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
WO2006026768A1 (en) 2004-09-01 2006-03-09 Microchips, Inc. Multi-cap reservoir devices for controlled release or exposure of reservoir contents
CN101080359A (zh) 2004-11-04 2007-11-28 微芯片公司 压入式冷焊密封方法和装置
US7413846B2 (en) * 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
JP4991694B2 (ja) * 2005-03-18 2012-08-01 クック メディカル テクノロジーズ エルエルシー 親水性を高め治療薬を送達するための新規な外表面積と貯留部を有するワイヤガイド
EP1872390A2 (de) * 2005-04-11 2008-01-02 The Board of Trustees of the Leland Stanford Junior University Mehrschichtige struktur mit vorgegebenem schichtmuster mit einem wirkstoff
AU2006267082A1 (en) * 2005-07-14 2007-01-18 Nano-Ditech Corporation Microfluidic devices and methods of preparing and using the same
DK1933810T3 (da) 2005-08-11 2013-01-28 Childrens Medical Center Intravesikal lægemiddelafgivelsesindretning og fremgangsmåde
JPWO2007026671A1 (ja) * 2005-08-29 2009-03-05 Ｔｔｉ・エルビュー株式会社 センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
US8005526B2 (en) * 2005-08-31 2011-08-23 The Regents Of The University Of Michigan Biologically integrated electrode devices
US9084546B2 (en) * 2005-08-31 2015-07-21 The Regents Of The University Of Michigan Co-electrodeposited hydrogel-conducting polymer electrodes for biomedical applications
US20070071807A1 (en) * 2005-09-28 2007-03-29 Hidero Akiyama Capsule-type drug-releasing device and capsule-type drug-releasing device system
BRPI0616771A2 (pt) * 2005-09-30 2011-06-28 Tti Ellebeau Inc dispositivo de iontoforese para liberar múltiplos agentes ativos para interfaces biológicas
US7574256B2 (en) * 2005-09-30 2009-08-11 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
CN101282684B (zh) * 2005-10-11 2011-05-25 皇家飞利浦电子股份有限公司 用于可植入装置的独立激活传感器
WO2007047556A2 (en) * 2005-10-14 2007-04-26 Microchips, Inc. Passive wear-indicating sensor for implantable prosthetic device
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US8998884B2 (en) 2005-11-09 2015-04-07 The Invention Science Fund I, Llc Remote controlled in situ reaction method
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US8936590B2 (en) 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US7942867B2 (en) 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US7699834B2 (en) 2005-11-09 2010-04-20 Searete Llc Method and system for control of osmotic pump device
US20070148697A1 (en) * 2005-12-27 2007-06-28 Boston Scientific Scimed, Inc. Methods and system for high throughput screening of polymer materials for medical devices
US8036738B2 (en) * 2006-03-14 2011-10-11 New Jersey Institute Of Technology Iontophoretic transdermal drug delivery system based on conductive polyaniline membrane
EP2012815A4 (de) * 2006-04-14 2009-12-09 Massachusetts Inst Technology Identifikation und modulierung molekularer pfade zur vermittlung neuronaler plastizität
US20070260174A1 (en) * 2006-05-05 2007-11-08 Searete Llc Detecting a failure to maintain a regimen
US20070275035A1 (en) * 2006-05-24 2007-11-29 Microchips, Inc. Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
EP1867990A1 (de) * 2006-06-14 2007-12-19 Koninklijke Philips Electronics N.V. Sensitiver Test mittels Verstärkung eines Etikettsignals
WO2008005458A2 (en) * 2006-07-05 2008-01-10 Tti Ellebeau, Inc. Delivery device having self-assembling dendritic polymers and method of use thereof
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
WO2008017042A1 (en) * 2006-08-03 2008-02-07 Microchips, Inc. Cardiac biosensor devices and methods
US8936794B2 (en) * 2006-08-25 2015-01-20 The Regents Of The University Of Michigan Conducting polymer nanotube actuators for precisely controlled release of medicine and bioactive molecules
KR20090060272A (ko) * 2006-09-05 2009-06-11 티티아이 엘뷰 가부시키가이샤 화합물의 이온 영동 특성을 평가하기 위한 임피던스 시스템, 장치 및 방법
CN101511421A (zh) * 2006-09-08 2009-08-19 皇家飞利浦电子股份有限公司 用于预定量物品的受控释放的设备
CA2703801A1 (en) * 2006-11-03 2008-05-08 Mcgill University Electrical microvalve and method of manufacturing thereof
EP2061551A2 (de) 2006-12-01 2009-05-27 TTI ellebeau, Inc. Systeme, vorrichtungen und verfahren zum antrieb oder zur steuerung von geräten, z. b. geräten zur transdermalen verabreichung
US20080181928A1 (en) * 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
JPWO2008087884A1 (ja) * 2007-01-16 2010-05-06 Ｔｔｉ・エルビュー株式会社 薬物投与量の予測方法及びそのプログラム
US8649840B2 (en) * 2007-06-07 2014-02-11 Microchips, Inc. Electrochemical biosensors and arrays
WO2009020607A2 (en) * 2007-08-07 2009-02-12 Arsenal Medical, Inc. Method and apparatus for composite drug delivery medical devices
US8753304B2 (en) 2007-08-17 2014-06-17 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter
US8734718B2 (en) 2007-08-17 2014-05-27 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
US8706211B2 (en) * 2007-08-17 2014-04-22 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having self-cleaning surfaces
US8702640B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc System, devices, and methods including catheters configured to monitor and inhibit biofilm formation
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
EP2200613B1 (de) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazin-derivate und ihre verwendungen
EP2052700A1 (de) * 2007-09-26 2009-04-29 Microchips, Inc. Arzneimittelverabreichungsvorrichtung und Verfahren zur Verwendung mit Prothesenimplantaten.
US20090099651A1 (en) * 2007-10-10 2009-04-16 Miv Therapeutics, Inc. Lipid coatings for implantable medical devices
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8989858B2 (en) 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
BRPI0820800B8 (pt) 2007-12-11 2021-06-22 Massachusetts Inst Technology dispositivo médico implantável para liberação controlada de droga
US8033164B2 (en) * 2007-12-20 2011-10-11 Dow Global Technologies Llc Corrosion testing apparatus and method
US8521273B2 (en) 2008-01-29 2013-08-27 Gilbert H. KLIMAN Drug delivery devices, kits and methods therefor
US7981106B2 (en) * 2008-02-26 2011-07-19 Pinchas Gilad Electronically-controlled device for release of drugs, proteins, and other organic or inorganic chemicals
US20090292325A1 (en) * 2008-05-02 2009-11-26 Cederna Paul S Hybrid bioelectrical interface device
WO2009155405A1 (en) * 2008-06-20 2009-12-23 Boston Scientific Scimed, Inc. Medical devices employing conductive polymers for delivery of therapeutic agents
US7951193B2 (en) 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US20100022494A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, device, and kit for maintaining physiological levels of steroid hormone in a subject
US20100022991A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System and device for maintaining physiological levels of steroid hormone in a subject
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
US20100022497A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject
CN102176931B (zh) 2008-08-09 2015-03-04 麻省理工学院 治疗男性泌尿生殖组织和外周组织的可植入药物递送设备和方法
US20100068235A1 (en) * 2008-09-16 2010-03-18 Searete LLC, a limited liability corporation of Deleware Individualizable dosage form
US20100068233A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Modifiable dosage form
US20100069887A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multiple chamber ex vivo adjustable-release final dosage form
US20100068275A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Personalizable dosage form
US20100069821A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-sites final dosage form
US20100068153A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo activatable final dosage form
US20100068283A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex VIVO modifiable particle or polymeric material medicament carrier
US20100068254A1 (en) * 2008-09-16 2010-03-18 Mahalaxmi Gita Bangera Modifying a medicament availability state of a final dosage form
US20100075532A1 (en) * 2008-09-25 2010-03-25 Tyco Healthcare Group Lp Fluorescent Marker for Detecting Gel or Lack of Gel
US20110208023A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
EP2384168B1 (de) 2008-12-04 2014-10-08 Searete LLC Aktiv kontrollierbare sterilisierende erregungsabgabe-implantate
US20110208021A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
US20110208026A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
US20110295088A1 (en) * 2008-12-04 2011-12-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including implantable devices with anti-microbial properties
US8236238B2 (en) 2009-01-21 2012-08-07 Palo Alto Research Center Incorporated Drug deactivation system
US9480795B2 (en) 2009-01-21 2016-11-01 Palo Alto Research Center Incorporated Sensor system for drug delivery device, drug delivery device having the same and method of using the same
US7838715B2 (en) * 2009-01-21 2010-11-23 Palo Alto Research Center Incorporated Drug deactivation system and method of deactivating a drug using the same
US8317737B2 (en) * 2009-02-25 2012-11-27 The Invention Science Fund I, Llc Device for actively removing a target component from blood or lymph of a vertebrate subject
US8246565B2 (en) * 2009-02-25 2012-08-21 The Invention Science Fund I, Llc Device for passively removing a target component from blood or lymph of a vertebrate subject
EP2401027B1 (de) * 2009-02-26 2017-11-01 The University of North Carolina At Chapel Hill Interventionelles arzneimittelabgabesystem
EA023156B1 (ru) 2009-06-26 2016-04-29 ТАРИС Биомедикал ЛЛК Устройство для доставки лекарств
US20110059148A1 (en) * 2009-09-07 2011-03-10 National Chiao Tung University Flexible Drug Delivery Chip, its Fabrication Method and Uses Thereof
US9017312B2 (en) * 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
ES2867399T3 (es) 2009-12-17 2021-10-20 Taris Biomedical Llc Dispositivo implantable con tolerabilidad intravesical
US8911426B2 (en) 2010-02-08 2014-12-16 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
WO2011102809A1 (en) * 2010-02-22 2011-08-25 Agency For Science, Technology And Research Process for manufacture of a micro-chamber array
CA2797429C (en) 2010-04-26 2018-09-18 National Research Council Of Canada Semipermanently closed microfluidic valve
US8251837B2 (en) * 2010-08-11 2012-08-28 Nike, Inc. Floating golf ball
JP2014503554A (ja) 2011-01-10 2014-02-13 タリス バイオメディカル，インコーポレイテッド 膀胱痛及び刺激性排尿の持続的治療の使用のためのリドカインレジメン
US9808616B2 (en) 2011-01-14 2017-11-07 The Regents Of The University Of Michigan Regenerative peripheral nerve interface
CA2825399A1 (en) 2011-02-04 2012-08-09 Taris Biomedical, Inc. Implantable device for controlled release of low solubility drug
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
PT2747642T (pt) 2011-08-25 2021-07-27 Microchips Biotech Inc Dispositivos de contenção eficientes em termos de espaço e método de criação dos mesmos
CN102431952B (zh) * 2011-10-27 2014-11-05 无锡英普林纳米科技有限公司 平面表面导电环阵列及其制备方法
US20150005595A1 (en) * 2011-12-30 2015-01-01 Kibur Medical, Inc. Implantable devices and methods for evaluation of active agents
CA2862443C (en) * 2011-12-30 2018-09-11 Kibur Medical, Inc. Implantable devices and methods for the evaluation of active agents
FR2991885A1 (fr) 2012-06-14 2013-12-20 Univ Lorraine Procede pour l'obtention de structures d'encapsulation
KR102142912B1 (ko) 2012-12-21 2020-08-10 마이크로칩스 바이오테크, 아이엔씨. 최소 침습 삽입을 위한 이식가능 의료 디바이스
US9620473B1 (en) 2013-01-18 2017-04-11 University Of Notre Dame Du Lac Quilt packaging system with interdigitated interconnecting nodules for inter-chip alignment
WO2014124184A1 (en) 2013-02-06 2014-08-14 California Institute Of Technology Miniaturized implantable electrochemical sensor devices
KR102262669B1 (ko) 2013-02-28 2021-06-09 마이크로칩스 바이오테크, 아이엔씨. 최소 침습 삽입을 위한 이식가능 의료 디바이스
SG11201507294WA (en) 2013-03-15 2015-10-29 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
US20140330244A1 (en) * 2013-05-02 2014-11-06 Elwha Llc Implantable Device for Manipulating Immune Cells
DK3030286T3 (da) 2013-08-05 2019-11-11 Cam Med Llc Komfortabel patch-pumpe
KR102385603B1 (ko) 2013-08-19 2022-04-11 타리스 바이오메디컬 엘엘씨 다중 유닛 약물 전달 장치 및 방법
US9937124B2 (en) 2014-09-11 2018-04-10 International Business Machines Corporation Microchip substance delivery devices having low-power electromechanical release mechanisms
US10314725B2 (en) 2014-11-13 2019-06-11 The Regents Of The University Of Michigan Method for amplifying signals from individual nerve fascicles
WO2016130962A1 (en) 2015-02-13 2016-08-18 Abbott Laboratories Automated storage modules for diagnostic analyzer liquids and related systems and methods
WO2016172704A1 (en) 2015-04-23 2016-10-27 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
US10368788B2 (en) * 2015-07-23 2019-08-06 California Institute Of Technology System and methods for wireless drug delivery on command
US11295612B2 (en) 2015-10-20 2022-04-05 Stc, Inc. Systems and methods for roadway management including feedback
US10881788B2 (en) 2015-10-30 2021-01-05 International Business Machines Corporation Delivery device including reactive material for programmable discrete delivery of a substance
US11285307B2 (en) * 2016-02-19 2022-03-29 University Of Florida Research Foundation, Incorporated Drug delivery integrated circuit (IC) and system
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
US20180100601A1 (en) * 2016-10-08 2018-04-12 Zepto Life Technology, LLC Electrolytic membrane valve
US10864358B2 (en) * 2017-05-02 2020-12-15 Bernard Fryshman Induction heating systems
US10737090B2 (en) 2017-07-11 2020-08-11 Medtronic, Inc. External defibrillation electrode conductive electrolyte dispersal pad
US10508755B2 (en) * 2017-07-21 2019-12-17 International Business Machines Corporation Fluid delivery device with hydrophobic surface
US20190076631A1 (en) * 2017-09-13 2019-03-14 Massachusetts Institute Of Technology Microdevices with complex geometries
CA3115924A1 (en) 2018-10-09 2020-04-16 Stc, Inc. Systems and methods for traffic priority systems
CA3133343A1 (en) 2019-03-13 2020-09-17 Stc, Inc. Protected right turn
KR102348997B1 (ko) * 2020-11-03 2022-01-07 성균관대학교산학협력단 초음파 선택적 반응 시한성 나노복합소재 기반 마찰전기 발전소자 및 이를 이용한 신경 자극 치료 장치

Family Cites Families (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE296998C (de)
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4731051A (en) * 1979-04-27 1988-03-15 The Johns Hopkins University Programmable control means for providing safe and controlled medication infusion
JPS57163309A (en) 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
CH670381A5 (de) * 1986-05-05 1989-06-15 Sulzer Ag
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4731049A (en) 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US4874500A (en) * 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
DE3908822A1 (de) 1989-03-18 1990-09-20 Voss Gunther Meinhardt Neue mikro-wirkstoffkapsel, die zeitlich und volumenmaessig kontrolliert, gezielt arzneistoffe abgeben kann
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5147297A (en) * 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
US5170801A (en) * 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5196002A (en) * 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
US5167625A (en) 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5102402A (en) * 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5893840A (en) * 1991-01-04 1999-04-13 Medtronic, Inc. Releasable microcapsules on balloon catheters
US5254081A (en) * 1991-02-01 1993-10-19 Empi, Inc. Multiple site drug iontophoresis electronic device and method
US5391164A (en) 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
JPH07501238A (ja) * 1991-08-26 1995-02-09 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー 電離療法装置及び方法
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
JP3456994B2 (ja) * 1991-11-13 2003-10-14 エラン コーポレーション ピーエルシー 薬物投与装置
US5193539A (en) * 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5429822A (en) * 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
US5756117A (en) * 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5449382A (en) * 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5368588A (en) 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5366454A (en) 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5427585A (en) * 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
US5474527A (en) * 1993-03-29 1995-12-12 Bettinger; David S. Positive displacement transdermal system
US5368704A (en) 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US5900160A (en) 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
US5651900A (en) * 1994-03-07 1997-07-29 The Regents Of The University Of California Microfabricated particle filter
US5770076A (en) * 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5985328A (en) 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5660680A (en) 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5893974A (en) 1994-03-07 1999-04-13 Regents Of University Of California Microfabricated capsules for immunological isolation of cell transplants
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
DE69534640T2 (de) * 1994-04-29 2006-08-10 Scimed Life Systems, Inc., Maple Grove Stent mit Kollagen
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US5891108A (en) * 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5992769A (en) 1995-06-09 1999-11-30 The Regents Of The University Of Michigan Microchannel system for fluid delivery
SE9502258D0 (sv) 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US6066163A (en) * 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
US6261584B1 (en) * 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
DE19610293C1 (de) * 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Vorrichtung zur gekapselten Aufnahme eines Materials
US6783543B2 (en) * 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
US5951881A (en) * 1996-07-22 1999-09-14 President And Fellows Of Harvard College Fabrication of small-scale cylindrical articles
JPH101666A (ja) * 1996-06-13 1998-01-06 Kasei Optonix Co Ltd アルミン酸塩蛍光体、その製造方法及び真空紫外線励起発光素子
US5769884A (en) * 1996-06-27 1998-06-23 Cordis Corporation Controlled porosity endovascular implant
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5792048A (en) * 1996-09-03 1998-08-11 Schaefer; Guenter Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners
US6387121B1 (en) * 1996-10-21 2002-05-14 Inflow Dynamics Inc. Vascular and endoluminal stents with improved coatings
US6099561A (en) * 1996-10-21 2000-08-08 Inflow Dynamics, Inc. Vascular and endoluminal stents with improved coatings
US6530951B1 (en) * 1996-10-24 2003-03-11 Cook Incorporated Silver implantable medical device
US6197013B1 (en) * 1996-11-06 2001-03-06 Setagon, Inc. Method and apparatus for drug and gene delivery
ZA9710342B (en) * 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6056734A (en) * 1997-02-07 2000-05-02 Sarcos Lc Method for automatic dosing of drugs
US5782799A (en) * 1997-02-07 1998-07-21 Sarcos, Inc. Method for automatic dosing of drugs
US5938923A (en) * 1997-04-15 1999-08-17 The Regents Of The University Of California Microfabricated filter and capsule using a substrate sandwich
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
DE19716683C1 (de) 1997-04-21 1998-06-04 Fraunhofer Ges Forschung Vorrichtung zur getrennten, gekapselten Aufnahme einer Mehrzahl gleicher oder unterschiedlicher Stoffe
US5879697A (en) * 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
GB9715101D0 (en) 1997-07-18 1997-09-24 Environmental Sensors Ltd The production of microstructures for analysis of fluids
DE19736520A1 (de) * 1997-08-22 1999-02-25 Lohmann Therapie Syst Lts Kennzeichnung für klebende flächenförmige dermale und transdermale therapeutische Darreichungsformen unter Verwendung eines klebenden Plfasters als Informationsträger, sowie Verfahren zu seiner Herstellung
US5972027A (en) * 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6273908B1 (en) * 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
US6163720A (en) * 1997-12-18 2000-12-19 Alza Corporation Layered rate controlling membranes for use in an electrotransport device
US6251688B1 (en) * 1998-03-20 2001-06-26 Ia, Inc. Method and apparatus for measurement of binding between a protein and a nucleotide
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
DE19816143A1 (de) * 1998-04-09 1999-10-21 Fischer Wilfried Transdermales Applikationssystem (TDS) mit Elektrodenraster
US6364856B1 (en) * 1998-04-14 2002-04-02 Boston Scientific Corporation Medical device with sponge coating for controlled drug release
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US20020038146A1 (en) * 1998-07-29 2002-03-28 Ulf Harry Expandable stent with relief cuts for carrying medicines and other materials
US6245104B1 (en) * 1999-02-28 2001-06-12 Inflow Dynamics Inc. Method of fabricating a biocompatible stent
DE19855421C2 (de) * 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6232150B1 (en) * 1998-12-03 2001-05-15 The Regents Of The University Of Michigan Process for making microstructures and microstructures made thereby
US6288888B1 (en) * 1998-12-25 2001-09-11 Nec Corporation Electric double layer capacitor
US6558422B1 (en) * 1999-03-26 2003-05-06 University Of Washington Structures having coated indentations
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
CA2379909C (en) * 1999-08-06 2011-01-04 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
US6527762B1 (en) 1999-08-18 2003-03-04 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US6361522B1 (en) * 1999-10-21 2002-03-26 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
EP1229901B1 (de) * 1999-11-17 2009-03-18 Boston Scientific Limited Miniaturisierte vorrichtungen zur abgabe von molekülen in einer trägerflüssigkeit
ATE323470T1 (de) * 1999-12-10 2006-05-15 Massachusetts Inst Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
US6328699B1 (en) * 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
ATE499988T1 (de) * 2000-03-02 2011-03-15 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
US6379382B1 (en) * 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US20020007215A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
WO2001091902A2 (en) * 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US6395326B1 (en) * 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
AU2001283358A1 (en) * 2000-08-14 2002-02-25 Pharmacia Corporation Drug delivery system with burst electrode
EP1339312B1 (de) * 2000-10-10 2006-01-04 Microchips, Inc. Mikrochip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
AU2002224453A1 (en) * 2000-10-11 2002-04-22 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
DE10063612C2 (de) 2000-12-20 2002-11-07 Fraunhofer Ges Forschung Mikrosystem zur Kontrolle der Wirkstoffabgabe aus einem Wirkstoffreservoir sowie Implantat mit Mikrosystem
CA2432438C (en) * 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
DE10102817B4 (de) 2001-01-23 2006-01-12 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Hitzepulsgestützten transdermalen Applikation von Wirkstoffen
US6571125B2 (en) * 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7338522B2 (en) * 2001-02-13 2008-03-04 Second Sight Medical Products, Inc. Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
WO2002089767A1 (en) * 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US6973718B2 (en) * 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
AU2002326304A1 (en) * 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
US6527938B2 (en) * 2001-06-21 2003-03-04 Syntheon, Llc Method for microporous surface modification of implantable metallic medical articles
ATE285756T1 (de) * 2001-06-28 2005-01-15 Microchips Inc Verfahren zum hermetischen versiegeln von mikrochip-reservoir-vorrichtungen
CN1729285A (zh) * 2001-06-29 2006-02-01 里兰·斯坦福初级大学董事会 电子修复视网膜的人造突触芯片界面
US6663615B1 (en) * 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
DE60331455D1 (de) * 2002-10-04 2010-04-08 Microchips Inc Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
US20050055080A1 (en) * 2003-09-05 2005-03-10 Naim Istephanous Modulated stents and methods of making the stents

Also Published As

Publication number Publication date
US6808522B2 (en) 2004-10-26
WO2001041736A2 (en) 2001-06-14
US20060189963A1 (en) 2006-08-24
US20020107470A1 (en) 2002-08-08
JP2003516343A (ja) 2003-05-13
CA2393603A1 (en) 2001-06-14
US20040248320A1 (en) 2004-12-09
AU2005234663A1 (en) 2005-12-15
ATE323470T1 (de) 2006-05-15
EP1235560A2 (de) 2002-09-04
AU4513101A (en) 2001-06-18
AU2005234663B2 (en) 2007-02-01
AU782639B2 (en) 2005-08-18
DE60027458T2 (de) 2007-07-05
CA2393603C (en) 2010-09-21
US7070592B2 (en) 2006-07-04
WO2001041736A3 (en) 2002-01-31
EP1235560B1 (de) 2006-04-19

Similar Documents

Publication Publication Date Title
DE60027458D1 (de) Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
DE69918310D1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
NZ508470A (en) Matrices formed of polymer and hydrophobic compounds for use in sustained release drug delivery
ATE386547T1 (de) Auf in vivo abbaubaren und quellbaren modifizierten dextranhydrogelen basierende systeme zur stossweisen freisetzung biologisch aktiver stoffe
DE60024605D1 (de) Katalytische prozesse für die kontrollierte polymerisation von freiradikalischen, copolymerisierbaren monomeren und funktionellpolymersysteme hergestellt davon
EP3021150A3 (de) Schwindarmes telekommunikationskabel
DE60041825D1 (de) Miniaturisierte vorrichtungen zur abgabe von molekülen in einer trägerflüssigkeit
HK1087031A1 (en) Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof
WO2007012012A3 (en) Medical devices containing sterilisation radiation resistant phenoxy polymers
WO2005079754A3 (en) Layered silicate nanoparticle-polymer composite medical articles
ES2138584T3 (es) Sistema de suministro de farmacos que implica la reaccion entre una proteina o un polipeptido y un polimero biodegradable hidrofobo.
WO2000021572A3 (en) Hydrogels and water soluble polymeric carriers for drug delivery
DK0417572T3 (da) Forlænget frigivelse af små vandopløselige molekyler
WO2003051286A2 (en) Hydrogel compositions, devices, and microscale components
ATE300286T1 (de) Gastroretentive pharmazeutische dosierungsformen mit gesteuerten abgaben
NO995313L (no) Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen
WO2007084418A3 (en) Microparticle containing matrices for drug delivery
AU2003265446A1 (en) Active agent delivery system including a hydrophilic polymer, medical device, and method
FR14C0042I1 (fr) Implant injectable a liberation prolongee comprenant un noyau a matrice bioerodable et un revetement bioerodable
WO2006030431A3 (en) Biocompatible drug delivery apparatus and methods
WO2004039427A3 (en) Transdermal delivery system for anti-emetic medication
DE60231862D1 (de) Erodierbare polymere zur injektion
BRPI0518515A2 (pt) copolÍmero em bloco, processo para a preparaÇço de copolÍmeros em bloco, e, polÍmero em bloco
Ito et al. A microfabrication method of a biodegradable polymer chip for a controlled release system
AU1789301A (en) Osmotic dosage form comprising first and second

Legal Events

Date Code Title Description
8364 No opposition during term of opposition