DE60020119D1 - Verfahren und Vorrichtung zur Untersuchung von Wirksstoffskandidaten und zur Bestimmung ihrer pharmakokinetischen Parametern - Google Patents

Verfahren und Vorrichtung zur Untersuchung von Wirksstoffskandidaten und zur Bestimmung ihrer pharmakokinetischen Parametern

Info

Publication number
DE60020119D1
DE60020119D1 DE60020119T DE60020119T DE60020119D1 DE 60020119 D1 DE60020119 D1 DE 60020119D1 DE 60020119 T DE60020119 T DE 60020119T DE 60020119 T DE60020119 T DE 60020119T DE 60020119 D1 DE60020119 D1 DE 60020119D1
Authority
DE
Germany
Prior art keywords
drug candidate
binding interaction
drug
adme
pharmacokinetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60020119T
Other languages
English (en)
Other versions
DE60020119T2 (de
Inventor
Maikku Haemaelaeinen
Robert Karlsson
Stefan Loefas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Biacore AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore AB filed Critical Biacore AB
Application granted granted Critical
Publication of DE60020119D1 publication Critical patent/DE60020119D1/de
Publication of DE60020119T2 publication Critical patent/DE60020119T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
DE60020119T 1999-06-18 2000-06-19 Verfahren und Vorrichtung zur Untersuchung von Wirksstoffskandidaten und zur Bestimmung ihrer pharmakokinetischen Parametern Expired - Lifetime DE60020119T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33686599A 1999-06-18 1999-06-18
US336865 1999-06-18
PCT/SE2000/001297 WO2000079268A2 (en) 1999-06-18 2000-06-19 Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith

Publications (2)

Publication Number Publication Date
DE60020119D1 true DE60020119D1 (de) 2005-06-16
DE60020119T2 DE60020119T2 (de) 2005-10-06

Family

ID=23318018

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60020119T Expired - Lifetime DE60020119T2 (de) 1999-06-18 2000-06-19 Verfahren und Vorrichtung zur Untersuchung von Wirksstoffskandidaten und zur Bestimmung ihrer pharmakokinetischen Parametern

Country Status (7)

Country Link
US (2) US6808938B2 (de)
EP (1) EP1188058B1 (de)
JP (1) JP4543187B2 (de)
AT (1) ATE295541T1 (de)
AU (1) AU775060B2 (de)
DE (1) DE60020119T2 (de)
WO (1) WO2000079268A2 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US7023547B2 (en) * 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US20020093654A1 (en) * 2000-07-11 2002-07-18 Lieberman Robert A. Apparatus and method for imaging
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US6833920B2 (en) * 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US20040180322A1 (en) * 2000-07-28 2004-09-16 Grass George M. Regional intestinal permeability model
EP1358611A2 (de) * 2000-07-28 2003-11-05 LION Bioscience AG System und verfahren zu voraussagen die adme/tox-eigenschaften einer verbindung
JP4027048B2 (ja) * 2001-02-23 2007-12-26 富士フイルム株式会社 全反射減衰を利用した測定方法および測定装置
US20050032243A1 (en) * 2001-07-25 2005-02-10 Pollack Gary M. Method and apparatus for rapid determination of ligand-protein binding using charcoal adsorption
US20030044992A1 (en) * 2001-08-31 2003-03-06 Chao Anthony C. Cell-based multiplexing ADME analysis using focused fluid flow
ATE361471T1 (de) * 2001-12-05 2007-05-15 Sense Proteomic Ltd Protein arrays für allelvarianten und deren verwendung
DE10160270A1 (de) * 2001-12-07 2003-06-26 Bayer Ag Computersystem und Verfahren zur Berechnung von ADME-Eigenschaften
EP1469309A4 (de) * 2001-12-27 2007-11-21 Japan Science & Tech Agency Verfahren zur beurteilung der zellaktivität
KR100555793B1 (ko) * 2002-06-25 2006-03-03 주식회사 마크로젠 고분자 그래프팅에 의해 표면이 개질된 바이오 지지체 및 그 제조방법
JP2006517397A (ja) * 2002-09-16 2006-07-27 センス プロテオミック リミテッド タンパク質アレイ、及びその使用方法
EP1439394A1 (de) * 2002-12-20 2004-07-21 Graffinity Pharmaceuticals Aktiengesellschaft Verfahren und Vorrichtung zum Erstellen von ADME Profilen in der frühen Wirkstoffentwicklung
US8741577B2 (en) * 2003-04-07 2014-06-03 Bio-Rad Laboratories Inc. Surface immobilised multilayer structure of vesicles
AU2004274843A1 (en) * 2003-09-24 2005-03-31 Ge Healthcare Bio-Sciences Ab Method and system for molecular interaction analysis
US7470549B2 (en) * 2004-05-26 2008-12-30 Fujifilm Corporation Measurement method using biosensor
AU2005257705A1 (en) * 2004-06-24 2006-01-05 Ge Healthcare Bio-Sciences Ab Method for detecting molecular surface interactions
SE0401633D0 (sv) * 2004-06-24 2004-06-24 Biacore Ab Method for detecting molecular surface interactions
JP4371954B2 (ja) 2004-08-31 2009-11-25 富士フイルム株式会社 表面プラズモン共鳴分析による被験物質の解析方法
JP4580291B2 (ja) * 2005-06-30 2010-11-10 富士フイルム株式会社 バイオセンサーを用いた測定方法
US20070003559A1 (en) * 2005-07-01 2007-01-04 Wyeth Methods of determining pharmacokinetics of targeted therapies
ES2336832T3 (es) 2005-07-22 2010-04-16 Five Prime Therapeutics, Inc. Composiciones y procedimientos para tratar enfermedades con proteinas de fusion de fgfr.
US7704695B2 (en) * 2005-07-29 2010-04-27 Xenoport, Inc. Screening of compounds for BGT1 transporter activity
US7700300B2 (en) * 2005-07-29 2010-04-20 Xenoport, Inc. Screening of compounds for GAT2 transporter activity
WO2007016164A2 (en) * 2005-07-29 2007-02-08 Xenoport, Inc. Cat1 transporters expressed in blood brain barrier cells
DE602005017148D1 (de) * 2005-08-30 2009-11-26 Perkinelmer Cellular Technolog Verfahren zum Nachweis einer biochemischen Interaktion
US8506502B2 (en) * 2006-09-16 2013-08-13 Terence Gilhuly Sensors and sensing for monitoring neuromuscular blockade
US7931791B2 (en) * 2006-10-25 2011-04-26 Southern Illinois University Carbondale Method of detecting analyte-biomolecule interactions
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US20120190127A1 (en) * 2009-06-15 2012-07-26 Brandeis University Systems and methods for determining process conditions in confined volumes
EP2498764B1 (de) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmentierte hydrogele
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
CN102667447B (zh) * 2009-11-30 2016-03-23 通用电气健康护理生物科学股份公司 用于结合行为分析的方法和系统
CN102667448B (zh) * 2009-11-30 2015-02-04 通用电气健康护理生物科学股份公司 用于相互作用分析的方法和系统
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
TWI382087B (zh) * 2010-05-24 2013-01-11 Univ Taipei Medical 一種篩檢拓樸異構酶抑制劑之裝置及其方法
GB2490652A (en) * 2011-04-18 2012-11-14 Microtest Matrices Ltd Methods of quantifying antibodies, especially IgE antibodies in a sample
JP5828507B2 (ja) * 2011-09-07 2015-12-09 国立大学法人金沢大学 尿検査方法及び尿検査用キット
EP2791667B1 (de) 2011-12-13 2018-03-28 3M Innovative Properties Company Verfahren zur identifizierung und quantitativen bestimmung einer unbekannten organischen verbindung in einem gasförmigen medium
EP3254108A1 (de) * 2015-02-06 2017-12-13 University of Rochester Auf polymermikropartikel basierendes verfahren zur sondenablagerung in markierungsfreien biosensoren
CN114791477B (zh) * 2021-01-25 2023-12-05 北京中医药大学 一种大蜜丸质构感官属性检测方法在质量控制中的应用
WO2022123332A1 (en) * 2021-08-09 2022-06-16 Debasish Banerjee Bioavailability and bioequivalence through intrinsic activity and kd measurements in vivo in humans
CN114112980B (zh) * 2022-01-24 2022-05-10 武汉宏韧生物医药股份有限公司 一种基于数据分析的药物组分检测方法与系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548066A (en) * 1984-08-07 1985-10-22 Rca Corporation Press workpiece thickness measuring system and method
US5338659A (en) 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
SE8902043L (sv) 1988-11-10 1990-05-11 Pharmacia Ab Foerfarande foer karakterisering av makromolekyler
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
SE501013C2 (sv) 1990-10-01 1994-10-17 Pharmacia Biosensor Ab Förfarande för förbättring av analys med bindning till fast fas
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
US5485277A (en) 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
SE9503028D0 (sv) 1995-09-01 1995-09-01 Pharmacia Biosensor Ab Method of analysing chemical and physical interactions at a sensor surface
GB9518429D0 (en) 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU8898198A (en) * 1997-08-08 1999-03-01 Alexander V Kabanov Methods of identifying biological agent compositions
US6289286B1 (en) * 1998-05-29 2001-09-11 Biacore Ab Surface regeneration of biosensors and characterization of biomolecules associated therewith
US6651008B1 (en) * 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics

Also Published As

Publication number Publication date
JP2003502668A (ja) 2003-01-21
AU6034000A (en) 2001-01-09
AU775060B2 (en) 2004-07-15
DE60020119T2 (de) 2005-10-06
ATE295541T1 (de) 2005-05-15
EP1188058B1 (de) 2005-05-11
JP4543187B2 (ja) 2010-09-15
WO2000079268A3 (en) 2001-07-19
US20020019019A1 (en) 2002-02-14
WO2000079268A2 (en) 2000-12-28
US20050037418A1 (en) 2005-02-17
EP1188058A2 (de) 2002-03-20
US6808938B2 (en) 2004-10-26

Similar Documents

Publication Publication Date Title
DE60020119D1 (de) Verfahren und Vorrichtung zur Untersuchung von Wirksstoffskandidaten und zur Bestimmung ihrer pharmakokinetischen Parametern
EP1312919A3 (de) Probevolumen-Messapparat
WO2007038754A3 (en) Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
Cozzolino et al. Feasibility study on the use of attenuated total reflectance mid-infrared for analysis of compositional parameters in wine
WO2003043487A3 (en) Method of using a non-antibody protein to detect and measure an analyte
ATE246378T1 (de) Verfahren zum feststellen der preparationsgüte von objektträgern und proben
DE60031427D1 (de) Verfahren zum kalibrieren einer spektroskopievorrichtung
DE59610431D1 (de) Optochemischer Fluoreszenzsensor sowie ein Verfahren zur Messung der Konzentration zumindest eines Analyten in einer Probe
ATE364721T1 (de) Verfahren zum charakterisieren von biologischen bedingungen, die kalibrierte genexpressionsprofile verwenden
WO2005095644A3 (de) Verfahren zur erkennung von signaturen in komplexen genexpressionsprofilen
DE602004020327D1 (de) Verfahren zur Detektierung von Temperaturänderungen
DE69910007D1 (de) Vorrichtung zum vorhersagen von physiologischen messwerten
CA2093015A1 (en) A method of calibrating a spectrometer using correlation between calibration sample spectra and measured spectra
WO2004063709A8 (en) Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
WO2005001462A8 (en) System and method for determining an abused sensor during analyte measurement in a biological fluid
WO2005094332A3 (en) Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators in non-small cell lung cancer
WO2006086566A3 (en) Methods and apparatuses for noninvasive determinations of analytes
AU2003298412A1 (en) Analytical platform and identification method
ATE370414T1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
WO2003017127A3 (en) Method for modelling biochemical pathways
CA2586654A1 (en) Use of asc as a marker for colorectal cancer
DE69702966T2 (de) Verfahren zur quantitativen bestimmung einer nukleinsäure in einer lösung durch messung der elektrischen leitfähigkeit und vorrichtung dafür
BRPI0412376A (pt) sensor de refletáncia altamente preciso para medição de umidade de revestimentos e pastas de pigmento
DE60220288D1 (de) Bestimmung der Genauigkeit eines Probevolumens in Biosensoren
MXPA05006804A (es) Identificacion, monitoreo y tratamiento de enfermedad infecciosa y caracterizacion de condiciones inflamatorias relacionadas con enfermedad infecciosa usando perfiles de expresion genica.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE BIO-SCIENCES AB, UPPSALA, SE

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

Ref document number: 1188058

Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB