DE50214903D1 - Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität - Google Patents

Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität

Info

Publication number: DE50214903D1
Authority: DE; Germany
Prior art keywords: zinc; arm; improved stability; insulin preparations; free
Prior art date: 2001-03-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE50214903T

Other languages

English (en)

Inventor

Peter Boderke

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis Deutschland GmbH

Original Assignee

Sanofi Aventis Deutschland GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-23

Filing date

2002-03-09

Publication date

2011-03-24

2002-03-09 Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH

2002-03-09 Priority to DE50214903T priority Critical patent/DE50214903D1/de

2011-03-24 Application granted granted Critical

2011-03-24 Publication of DE50214903D1 publication Critical patent/DE50214903D1/de

2022-03-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
239000011701 zinc Substances 0.000 title 2
229910052725 zinc Inorganic materials 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
238000002360 preparation method Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

DE50214903T 2001-03-23 2002-03-09 Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität Expired - Lifetime DE50214903D1 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE50214903T DE50214903D1 (de)	2001-03-23	2002-03-09	Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10114178A DE10114178A1 (de)	2001-03-23	2001-03-23	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
PCT/EP2002/002625 WO2002076495A1 (de)	2001-03-23	2002-03-09	Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität
DE50214903T DE50214903D1 (de)	2001-03-23	2002-03-09	Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität

Publications (1)

Publication Number	Publication Date
DE50214903D1 true DE50214903D1 (de)	2011-03-24

Family

ID=7678654

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE10114178A Ceased DE10114178A1 (de)	2001-03-23	2001-03-23	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE50214903T Expired - Lifetime DE50214903D1 (de)	2001-03-23	2002-03-09	Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE10114178A Ceased DE10114178A1 (de)	2001-03-23	2001-03-23	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität

Country Status (32)

Country	Link
US (5)	US6960561B2 (de)
EP (2)	EP1381385B1 (de)
JP (1)	JP4231292B2 (de)
KR (2)	KR100987311B1 (de)
CN (1)	CN1273187C (de)
AR (2)	AR033059A1 (de)
AT (1)	ATE497777T1 (de)
AU (1)	AU2002302409B2 (de)
BR (1)	BRPI0208210B8 (de)
CA (1)	CA2441260C (de)
CY (2)	CY1111413T1 (de)
DE (2)	DE10114178A1 (de)
DK (2)	DK1381385T3 (de)
ES (2)	ES2360505T3 (de)
HK (1)	HK1061521A1 (de)
HR (1)	HRP20030765B1 (de)
HU (1)	HU228847B1 (de)
IL (2)	IL158057A0 (de)
ME (1)	ME00408B (de)
MX (1)	MXPA03007942A (de)
MY (1)	MY129417A (de)
NO (1)	NO326780B1 (de)
NZ (1)	NZ528335A (de)
PE (1)	PE20020968A1 (de)
PL (1)	PL205465B1 (de)
PT (2)	PT1381385E (de)
RS (1)	RS51579B (de)
RU (1)	RU2311922C2 (de)
SI (1)	SI1381385T1 (de)
TW (1)	TWI301761B (de)
WO (1)	WO2002076495A1 (de)
ZA (1)	ZA200306637B (de)

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2001
- 2001-03-23 DE DE10114178A patent/DE10114178A1/de not_active Ceased
2002
- 2002-03-09 WO PCT/EP2002/002625 patent/WO2002076495A1/de active Application Filing
- 2002-03-09 RU RU2003131187/15A patent/RU2311922C2/ru active
- 2002-03-09 CA CA2441260A patent/CA2441260C/en not_active Expired - Lifetime
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- 2002-03-09 DK DK02729985.8T patent/DK1381385T3/da active
- 2002-03-09 RS YU73503A patent/RS51579B/sr unknown
- 2002-03-09 MX MXPA03007942A patent/MXPA03007942A/es active IP Right Grant
- 2002-03-09 AT AT02729985T patent/ATE497777T1/de active
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- 2002-03-09 DE DE50214903T patent/DE50214903D1/de not_active Expired - Lifetime
- 2002-03-09 HU HU0303596A patent/HU228847B1/hu unknown
- 2002-03-09 PL PL362800A patent/PL205465B1/pl unknown
- 2002-03-09 DK DK10178836.2T patent/DK2289539T3/da active
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- 2002-03-09 EP EP10178836A patent/EP2289539B1/de not_active Expired - Lifetime
- 2002-03-09 PT PT02729985T patent/PT1381385E/pt unknown
- 2002-03-09 SI SI200230934T patent/SI1381385T1/sl unknown
- 2002-03-09 KR KR1020037012339A patent/KR100987311B1/ko active IP Right Grant
- 2002-03-09 KR KR1020107011428A patent/KR20100061868A/ko not_active Application Discontinuation
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- 2002-03-21 TW TW091105385A patent/TWI301761B/zh not_active IP Right Cessation
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- 2002-03-22 US US10/102,862 patent/US6960561B2/en not_active Expired - Lifetime
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2004
- 2004-06-19 HK HK04104454A patent/HK1061521A1/xx not_active IP Right Cessation
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2007
- 2007-03-08 US US11/683,747 patent/US7452860B2/en not_active Expired - Lifetime
2008
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- 2011-03-03 CY CY20111100253T patent/CY1111413T1/el unknown
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Also Published As

Publication number	Publication date
CN1273187C (zh)	2006-09-06
DE10114178A1 (de)	2002-10-10
HRP20030765A2 (en)	2005-06-30
HU228847B1 (en)	2013-06-28
AR096376A2 (es)	2015-12-23
IL158057A (en)	2013-10-31
CY1111413T1 (el)	2015-08-05
ES2393180T3 (es)	2012-12-19
US7205276B2 (en)	2007-04-17
WO2002076495A1 (de)	2002-10-03
DK1381385T3 (da)	2011-06-06
SI1381385T1 (sl)	2011-05-31
EP1381385B1 (de)	2011-02-09
HRP20030765B1 (en)	2011-10-31
US20090186807A1 (en)	2009-07-23
MY129417A (en)	2007-03-30
JP4231292B2 (ja)	2009-02-25
NO326780B1 (no)	2009-02-16
ATE497777T1 (de)	2011-02-15
ME00408B (de)	2011-10-10
US20030004096A1 (en)	2003-01-02
KR100987311B1 (ko)	2010-10-13
RU2003131187A (ru)	2005-03-10
PL205465B1 (pl)	2010-04-30
AU2002302409B2 (en)	2007-01-04
US20070155653A1 (en)	2007-07-05
CN1498113A (zh)	2004-05-19
PE20020968A1 (es)	2002-12-10
RS51579B (sr)	2011-08-31
AR033059A1 (es)	2003-12-03
HUP0303596A3 (en)	2005-11-28
PT1381385E (pt)	2011-03-17
US7452860B2 (en)	2008-11-18
HUP0303596A2 (hu)	2004-01-28
EP2289539B1 (de)	2012-09-19
US7696162B2 (en)	2010-04-13
RU2311922C2 (ru)	2007-12-10
CA2441260C (en)	2011-04-26
MXPA03007942A (es)	2004-04-02
US6960561B2 (en)	2005-11-01
JP2004523589A (ja)	2004-08-05
BRPI0208210B1 (pt)	2018-05-02
NO20034125D0 (no)	2003-09-16
US7205277B2 (en)	2007-04-17
US20050187142A1 (en)	2005-08-25
ZA200306637B (en)	2004-05-07
BR0208210A (pt)	2004-03-09
PL362800A1 (en)	2004-11-02
ES2360505T3 (es)	2011-06-06
US20050187143A1 (en)	2005-08-25
IL158057A0 (en)	2004-03-28
MEP60808A (en)	2011-05-10
TWI301761B (en)	2008-10-11
HK1061521A1 (en)	2004-09-24
NZ528335A (en)	2005-03-24
EP2289539A1 (de)	2011-03-02
NO20034125L (no)	2003-11-11
KR20100061868A (ko)	2010-06-09
KR20040011483A (ko)	2004-02-05
PT2289539E (pt)	2012-11-20
CA2441260A1 (en)	2002-10-03
DK2289539T3 (da)	2013-01-14
CY1113318T1 (el)	2016-04-13
EP1381385A1 (de)	2004-01-21
YU73503A (sh)	2006-05-25
BRPI0208210B8 (pt)	2021-05-25

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