US5258506A
(en)
*
|
1984-10-16 |
1993-11-02 |
Chiron Corporation |
Photolabile reagents for incorporation into oligonucleotide chains
|
US5430136A
(en)
*
|
1984-10-16 |
1995-07-04 |
Chiron Corporation |
Oligonucleotides having selectably cleavable and/or abasic sites
|
US5714380A
(en)
|
1986-10-23 |
1998-02-03 |
Amoco Corporation |
Closed vessel for isolating target molecules and for performing amplification
|
US5720928A
(en)
*
|
1988-09-15 |
1998-02-24 |
New York University |
Image processing and analysis of individual nucleic acid molecules
|
US6147198A
(en)
*
|
1988-09-15 |
2000-11-14 |
New York University |
Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
|
US5324829A
(en)
*
|
1988-12-16 |
1994-06-28 |
Ortho Diagnostic Systems, Inc. |
High specific activity nucleic acid probes having target recognition and signal generating moieties
|
US6610256B2
(en)
|
1989-04-05 |
2003-08-26 |
Wisconsin Alumni Research Foundation |
Image processing and analysis of individual nucleic acid molecules
|
US5102784A
(en)
*
|
1990-05-04 |
1992-04-07 |
Oncor, Inc. |
Restriction amplification assay
|
US5677440A
(en)
*
|
1990-07-16 |
1997-10-14 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Oligonucleotide-polyamide conjugates
|
EP0529070A1
(de)
*
|
1991-02-27 |
1993-03-03 |
Amoco Corporation |
Verfahren zur verbesserung der empfindlichkeit von hybridisierungsassays
|
KR940701454A
(ko)
*
|
1991-06-17 |
1994-05-28 |
로버트 피. 블랙버언 |
선택가능한 절단부위로의 폴리뉴클레오티드의 결정
|
US5294534A
(en)
*
|
1991-08-13 |
1994-03-15 |
Miles, Inc. |
Amplification method for polynucleotide assays
|
US6872816B1
(en)
*
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
US5846717A
(en)
|
1996-01-24 |
1998-12-08 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
US5994069A
(en)
*
|
1996-01-24 |
1999-11-30 |
Third Wave Technologies, Inc. |
Detection of nucleic acids by multiple sequential invasive cleavages
|
WO1993005184A1
(en)
*
|
1991-09-10 |
1993-03-18 |
Love Jack D |
Dna/rna target and signal amplification
|
US6017696A
(en)
|
1993-11-01 |
2000-01-25 |
Nanogen, Inc. |
Methods for electronic stringency control for molecular biological analysis and diagnostics
|
US6652808B1
(en)
*
|
1991-11-07 |
2003-11-25 |
Nanotronics, Inc. |
Methods for the electronic assembly and fabrication of devices
|
US6569382B1
(en)
*
|
1991-11-07 |
2003-05-27 |
Nanogen, Inc. |
Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
|
US5632957A
(en)
*
|
1993-11-01 |
1997-05-27 |
Nanogen |
Molecular biological diagnostic systems including electrodes
|
GB9207380D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Compounds
|
GB9207381D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Synthesis of oligonucleotides
|
EP1130116A3
(de)
*
|
1992-04-06 |
2004-01-14 |
Abbott Laboratories |
Methode und Gerät zur Detektion von Nukleinsäuren unter Verwendung von totaler interner Reflektion
|
US5543292A
(en)
*
|
1992-06-16 |
1996-08-06 |
Hitachi, Ltd. |
Process for the measurement of nucleic acids
|
US5795714A
(en)
*
|
1992-11-06 |
1998-08-18 |
Trustees Of Boston University |
Method for replicating an array of nucleic acid probes
|
US6436635B1
(en)
*
|
1992-11-06 |
2002-08-20 |
Boston University |
Solid phase sequencing of double-stranded nucleic acids
|
US5614402A
(en)
*
|
1992-12-07 |
1997-03-25 |
Third Wave Technologies, Inc. |
5' nucleases derived from thermostable DNA polymerase
|
DE69433811T2
(de)
|
1993-01-07 |
2005-06-23 |
Sequenom, Inc., San Diego |
Dns - sequenzierung durch massenspektronomie
|
US6194144B1
(en)
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
US5605798A
(en)
*
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
KR960700349A
(ko)
*
|
1993-01-08 |
1996-01-19 |
다알렌 반스톤 |
체액 또는 조직으로부터 추출된 합성 올리고누클레오티드의 검출방법(detection of synthetic oligonucleotides extracted from body fluids or tissues)
|
US5679510A
(en)
*
|
1993-04-27 |
1997-10-21 |
Hybridon, Inc. |
Quantitative detection of specific nucleic acid sequences using lambdoid bacteriophages linked by oligonucleotides to solid support
|
JP2842758B2
(ja)
*
|
1993-05-10 |
1999-01-06 |
株式会社日立製作所 |
自動分析装置
|
US6225059B1
(en)
|
1993-11-01 |
2001-05-01 |
Nanogen, Inc. |
Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
|
US6331274B1
(en)
|
1993-11-01 |
2001-12-18 |
Nanogen, Inc. |
Advanced active circuits and devices for molecular biological analysis and diagnostics
|
US7314708B1
(en)
*
|
1998-08-04 |
2008-01-01 |
Nanogen, Inc. |
Method and apparatus for electronic synthesis of molecular structures
|
EP0736103A4
(de)
*
|
1993-12-17 |
1999-07-28 |
Roger S Cubicciotti |
Auf nukleotide gerichtete zusammenstellung von bimolekularen und multimolekularen medikamenten vorrichtungen
|
US6986985B1
(en)
|
1994-01-13 |
2006-01-17 |
Enzo Life Sciences, Inc. |
Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
|
US20050123926A1
(en)
*
|
1994-01-13 |
2005-06-09 |
Enzo Diagnostics, Inc., |
In vitro process for producing multiple nucleic acid copies
|
US20110097791A1
(en)
*
|
1999-04-16 |
2011-04-28 |
Engelhardt Dean L |
Novel process, construct and conjugate for producing multiple nucleic acid copies
|
US5484702A
(en)
*
|
1994-01-27 |
1996-01-16 |
Research Foundation Of The State University Of New York At Buffalo |
Method for preselecting recombinant clones containing a specific nucleic acid sequence and subsequent transformation with preselected clones
|
WO1995025538A1
(en)
*
|
1994-03-18 |
1995-09-28 |
The General Hospital Corporation |
Cleaved amplified rflp detection methods
|
US6110709A
(en)
*
|
1994-03-18 |
2000-08-29 |
The General Hospital Corporation |
Cleaved amplified modified polymorphic sequence detection methods
|
US5714330A
(en)
*
|
1994-04-04 |
1998-02-03 |
Lynx Therapeutics, Inc. |
DNA sequencing by stepwise ligation and cleavage
|
US5552278A
(en)
*
|
1994-04-04 |
1996-09-03 |
Spectragen, Inc. |
DNA sequencing by stepwise ligation and cleavage
|
US5831065A
(en)
*
|
1994-04-04 |
1998-11-03 |
Lynx Therapeutics, Inc. |
Kits for DNA sequencing by stepwise ligation and cleavage
|
US6589736B1
(en)
*
|
1994-11-22 |
2003-07-08 |
The Trustees Of Boston University |
Photocleavable agents and conjugates for the detection and isolation of biomolecules
|
US5876924A
(en)
*
|
1994-06-22 |
1999-03-02 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method hybridization signal amplification method (HSAM)
|
US20070269799A9
(en)
*
|
1994-06-22 |
2007-11-22 |
Zhang David Y |
Nucleic acid amplification methods
|
US6593086B2
(en)
|
1996-05-20 |
2003-07-15 |
Mount Sinai School Of Medicine Of New York University |
Nucleic acid amplification methods
|
USRE38442E1
(en)
*
|
1994-06-22 |
2004-02-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method hybridization signal amplification method (HSAM)
|
US5942391A
(en)
*
|
1994-06-22 |
1999-08-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method: ramification-extension amplification method (RAM)
|
US5552471A
(en)
*
|
1994-08-17 |
1996-09-03 |
The Perkin-Elmer Corporation |
Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
|
US5597909A
(en)
*
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
US5580731A
(en)
*
|
1994-08-25 |
1996-12-03 |
Chiron Corporation |
N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
|
US5990300A
(en)
*
|
1994-09-02 |
1999-11-23 |
Andrew C. Hiatt |
Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US5872244A
(en)
*
|
1994-09-02 |
1999-02-16 |
Andrew C. Hiatt |
3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
|
US6214987B1
(en)
*
|
1994-09-02 |
2001-04-10 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
|
US6232465B1
(en)
|
1994-09-02 |
2001-05-15 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US5763594A
(en)
*
|
1994-09-02 |
1998-06-09 |
Andrew C. Hiatt |
3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
|
US5808045A
(en)
*
|
1994-09-02 |
1998-09-15 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US6013445A
(en)
*
|
1996-06-06 |
2000-01-11 |
Lynx Therapeutics, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
US6974666B1
(en)
*
|
1994-10-21 |
2005-12-13 |
Appymetric, Inc. |
Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
|
US5660979A
(en)
*
|
1994-11-04 |
1997-08-26 |
Akzo Nobel N.V. |
Detection of human retrovirus infection
|
US20030104361A1
(en)
*
|
1997-09-29 |
2003-06-05 |
Susan Weininger |
Method of detection of nucleic acids with a specific sequence composition
|
US5871902A
(en)
*
|
1994-12-09 |
1999-02-16 |
The Gene Pool, Inc. |
Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
|
ES2185719T3
(es)
*
|
1994-12-23 |
2003-05-01 |
Dade Behring Inc |
Deteccion de acidos nucleicos por formacion de un producto catalizada por diana.
|
DE69631988T2
(de)
*
|
1995-01-12 |
2005-02-10 |
Toyo Boseki K.K. |
Neue alkalische Phosphatase, deren Herstellung und Verwendung
|
US5559000A
(en)
*
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
US6428955B1
(en)
|
1995-03-17 |
2002-08-06 |
Sequenom, Inc. |
DNA diagnostics based on mass spectrometry
|
EP0871640A4
(de)
|
1995-04-03 |
2002-04-17 |
Univ New York |
Verfahren zur messung physikalischer eigenschaften von nukleinsäuren durch mikropische abbildung
|
US8142708B2
(en)
*
|
1995-04-03 |
2012-03-27 |
Wisconsin Alumni Research Foundation |
Micro fluidic system for single molecule imaging
|
US7775368B2
(en)
*
|
1995-04-03 |
2010-08-17 |
Wisconsin Alumni Research Foundation |
Micro-channel long molecule manipulation system
|
US7803529B1
(en)
|
1995-04-11 |
2010-09-28 |
Sequenom, Inc. |
Solid phase sequencing of biopolymers
|
US20060063193A1
(en)
*
|
1995-04-11 |
2006-03-23 |
Dong-Jing Fu |
Solid phase sequencing of double-stranded nucleic acids
|
US5750341A
(en)
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
US5830655A
(en)
|
1995-05-22 |
1998-11-03 |
Sri International |
Oligonucleotide sizing using cleavable primers
|
US5700642A
(en)
*
|
1995-05-22 |
1997-12-23 |
Sri International |
Oligonucleotide sizing using immobilized cleavable primers
|
US6027879A
(en)
*
|
1995-08-09 |
2000-02-22 |
The Regents Of The University Of California |
Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe
|
US6146854A
(en)
*
|
1995-08-31 |
2000-11-14 |
Sequenom, Inc. |
Filtration processes, kits and devices for isolating plasmids
|
US5747255A
(en)
*
|
1995-09-29 |
1998-05-05 |
Lynx Therapeutics, Inc. |
Polynucleotide detection by isothermal amplification using cleavable oligonucleotides
|
US6849398B1
(en)
|
1996-01-18 |
2005-02-01 |
The Scripps Research Institute |
Use of encoded reaction cassette
|
CN1159452C
(zh)
*
|
1996-01-23 |
2004-07-28 |
佳根基因组学公司 |
利用非荧光标记检测配体对结合的方法和组合物
|
US6613508B1
(en)
|
1996-01-23 |
2003-09-02 |
Qiagen Genomics, Inc. |
Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
|
WO1997027325A2
(en)
*
|
1996-01-23 |
1997-07-31 |
Rapigene, Inc. |
Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
|
NZ331044A
(en)
*
|
1996-01-23 |
1999-02-25 |
Rapigene Inc |
Methods and compositions for determining the sequence of nucleic acid molecules
|
US6312893B1
(en)
*
|
1996-01-23 |
2001-11-06 |
Qiagen Genomics, Inc. |
Methods and compositions for determining the sequence of nucleic acid molecules
|
EP0992511B1
(de)
*
|
1996-01-23 |
2009-03-11 |
Operon Biotechnologies, Inc. |
Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen
|
US6027890A
(en)
*
|
1996-01-23 |
2000-02-22 |
Rapigene, Inc. |
Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
|
US6706471B1
(en)
|
1996-01-24 |
2004-03-16 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
US7195871B2
(en)
*
|
1996-01-24 |
2007-03-27 |
Third Wave Technologies, Inc |
Methods and compositions for detecting target sequences
|
US20080160524A1
(en)
*
|
1996-01-24 |
2008-07-03 |
Third Wave Technologies, Inc. |
Methods and Compositions for Detecting Target Sequences
|
US7122364B1
(en)
*
|
1998-03-24 |
2006-10-17 |
Third Wave Technologies, Inc. |
FEN endonucleases
|
US5985557A
(en)
|
1996-01-24 |
1999-11-16 |
Third Wave Technologies, Inc. |
Invasive cleavage of nucleic acids
|
US6090606A
(en)
*
|
1996-01-24 |
2000-07-18 |
Third Wave Technologies, Inc. |
Cleavage agents
|
EP1634890B1
(de)
*
|
1996-01-24 |
2008-11-19 |
Third Wave Technologies, Inc. |
Invasive Spaltung von Nukleinsäuren
|
US6875572B2
(en)
|
1996-01-24 |
2005-04-05 |
Third Wave Technologies, Inc. |
Nucleic acid detection assays
|
US7432048B2
(en)
*
|
1996-11-29 |
2008-10-07 |
Third Wave Technologies, Inc. |
Reactions on a solid surface
|
US7527928B2
(en)
*
|
1996-11-29 |
2009-05-05 |
Third Wave Technologies, Inc. |
Reactions on a solid surface
|
AU1710997A
(en)
*
|
1996-01-26 |
1997-08-20 |
Codon Pharmaceuticals, Inc. |
Oligonucleotide analogs
|
US5824478A
(en)
*
|
1996-04-30 |
1998-10-20 |
Vysis, Inc. |
Diagnostic methods and probes
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
US6342349B1
(en)
*
|
1996-07-08 |
2002-01-29 |
Burstein Technologies, Inc. |
Optical disk-based assay devices and methods
|
WO1998001533A1
(en)
*
|
1996-07-08 |
1998-01-15 |
Burstein Laboratories, Inc. |
Cleavable signal element device and method
|
US6780982B2
(en)
*
|
1996-07-12 |
2004-08-24 |
Third Wave Technologies, Inc. |
Charge tags and the separation of nucleic acid molecules
|
US5858665A
(en)
*
|
1996-07-25 |
1999-01-12 |
Navix, Inc. |
Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
|
US5853990A
(en)
|
1996-07-26 |
1998-12-29 |
Edward E. Winger |
Real time homogeneous nucleotide assay
|
US6352827B1
(en)
*
|
1996-08-28 |
2002-03-05 |
President And Fellows Of Harvard College |
Detection of multiple nucleic acid sequences in a fluid sample
|
US5777324A
(en)
|
1996-09-19 |
1998-07-07 |
Sequenom, Inc. |
Method and apparatus for maldi analysis
|
US6140053A
(en)
*
|
1996-11-06 |
2000-10-31 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry via exonuclease degradation
|
ATE259056T1
(de)
|
1996-11-06 |
2004-02-15 |
Sequenom Inc |
Verfahren zur massenspektrometrie
|
US5900481A
(en)
*
|
1996-11-06 |
1999-05-04 |
Sequenom, Inc. |
Bead linkers for immobilizing nucleic acids to solid supports
|
US6024925A
(en)
|
1997-01-23 |
2000-02-15 |
Sequenom, Inc. |
Systems and methods for preparing low volume analyte array elements
|
US6133436A
(en)
|
1996-11-06 |
2000-10-17 |
Sequenom, Inc. |
Beads bound to a solid support and to nucleic acids
|
ATE375403T1
(de)
*
|
1996-11-06 |
2007-10-15 |
Sequenom Inc |
Dna-diagnostik mittels massenspektrometrie
|
US7285422B1
(en)
*
|
1997-01-23 |
2007-10-23 |
Sequenom, Inc. |
Systems and methods for preparing and analyzing low volume analyte array elements
|
EP2374890B1
(de)
|
1996-11-29 |
2012-11-14 |
Third Wave Technologies, Inc. |
FEN-1-Endonucleasen, Mischungen und Spaltungsverfahren
|
US6706473B1
(en)
|
1996-12-06 |
2004-03-16 |
Nanogen, Inc. |
Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
|
AU5794498A
(en)
|
1996-12-10 |
1998-07-03 |
Genetrace Systems, Inc. |
Releasable nonvolatile mass-label molecules
|
US5905024A
(en)
*
|
1996-12-17 |
1999-05-18 |
University Of Chicago |
Method for performing site-specific affinity fractionation for use in DNA sequencing
|
NZ337893A
(en)
*
|
1997-02-21 |
2001-09-28 |
Burstein Technologies Inc |
Determining sequence of a gene by providing all or a subset of possible sequences and assaying for hybridised oligonucleotides for massive de novo sequencing which cannot be performed using PCR due to its limitations
|
US5846726A
(en)
*
|
1997-05-13 |
1998-12-08 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
CA2290510A1
(en)
*
|
1997-05-21 |
1998-11-26 |
Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) |
Method and kit for detecting dna mutations using restriction enzymes
|
US5928869A
(en)
*
|
1997-05-30 |
1999-07-27 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
CN1270598A
(zh)
*
|
1997-07-22 |
2000-10-18 |
拉普吉恩公司 |
用于质谱分析核酸的方法和组合物
|
US6365731B1
(en)
|
1997-08-06 |
2002-04-02 |
Ambion, Inc. |
Stripping nucleic acids with iodine and sodium thiosulfate
|
US5955378A
(en)
*
|
1997-08-20 |
1999-09-21 |
Challener; William A. |
Near normal incidence optical assaying method and system having wavelength and angle sensitivity
|
US6207370B1
(en)
|
1997-09-02 |
2001-03-27 |
Sequenom, Inc. |
Diagnostics based on mass spectrometric detection of translated target polypeptides
|
US8182991B1
(en)
|
1997-11-26 |
2012-05-22 |
Third Wave Technologies, Inc. |
FEN-1 endonucleases, mixtures and cleavage methods
|
US6268131B1
(en)
|
1997-12-15 |
2001-07-31 |
Sequenom, Inc. |
Mass spectrometric methods for sequencing nucleic acids
|
GB9815163D0
(en)
*
|
1998-07-13 |
1998-09-09 |
Brax Genomics Ltd |
Compounds
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
EP1063286A4
(de)
*
|
1998-02-09 |
2004-03-24 |
Toyo Kohan Co Ltd |
Substrate zur immobilisierung und amplifikation von dns, dns-immobilisierte chips mit immobilisierter dns auf den substraten und methode zur dns amplifikation
|
US6723564B2
(en)
|
1998-05-07 |
2004-04-20 |
Sequenom, Inc. |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
|
US6607888B2
(en)
|
1998-10-20 |
2003-08-19 |
Wisconsin Alumni Research Foundation |
Method for analyzing nucleic acid reactions
|
US6221592B1
(en)
|
1998-10-20 |
2001-04-24 |
Wisconsin Alumi Research Foundation |
Computer-based methods and systems for sequencing of individual nucleic acid molecules
|
US20020025519A1
(en)
|
1999-06-17 |
2002-02-28 |
David J. Wright |
Methods and oligonucleotides for detecting nucleic acid sequence variations
|
US6201112B1
(en)
*
|
1999-07-22 |
2001-03-13 |
Agilent Technologies Inc. |
Method for 3′ end-labeling ribonucleic acids
|
US6528319B1
(en)
*
|
1999-09-02 |
2003-03-04 |
Amersham Biosciences Corp |
Method for anchoring oligonucleotides to a substrate
|
US6893819B1
(en)
*
|
2000-11-21 |
2005-05-17 |
Stratagene California |
Methods for detection of a nucleic acid by sequential amplification
|
US7824859B2
(en)
*
|
1999-10-29 |
2010-11-02 |
Cytyc Corporation |
Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
|
US7118860B2
(en)
|
1999-10-29 |
2006-10-10 |
Stratagene California |
Methods for detection of a target nucleic acid by capture
|
US7838225B2
(en)
*
|
1999-10-29 |
2010-11-23 |
Hologic, Inc. |
Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
|
JP2001204463A
(ja)
*
|
2000-01-27 |
2001-07-31 |
Toyo Kohan Co Ltd |
ヌクレオチド固定用担体
|
AU4769701A
(en)
|
2000-03-22 |
2001-10-03 |
Solulink Inc |
Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
|
CA2406236C
(en)
*
|
2000-04-17 |
2013-02-19 |
Dyax Corp. |
Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
|
US8288322B2
(en)
|
2000-04-17 |
2012-10-16 |
Dyax Corp. |
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
|
ATE423221T1
(de)
|
2000-06-13 |
2009-03-15 |
Univ Boston |
Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
|
US6627748B1
(en)
|
2000-09-11 |
2003-09-30 |
The Trustees Of Columbia University In The City Of New York |
Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
|
US20060057565A1
(en)
*
|
2000-09-11 |
2006-03-16 |
Jingyue Ju |
Combinatorial fluorescence energy transfer tags and uses thereof
|
US7829348B2
(en)
*
|
2000-09-22 |
2010-11-09 |
Iowa State University Research Foundation, Inc. |
Raman-active reagents and the use thereof
|
ATE315957T1
(de)
|
2000-09-25 |
2006-02-15 |
Picoliter Inc |
Schallausstoss von fluiden aus mehreren behältern
|
ES2327316T3
(es)
|
2000-09-26 |
2009-10-28 |
Boston Probes, Inc. |
Sondas, conjuntos de sondas, metodos y kits que se refieren a la deteccion, identificacion y/o enumeracion de bacterias.
|
JP2004510433A
(ja)
*
|
2000-10-06 |
2004-04-08 |
ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク |
Dnaおよびrnaを解読するための大量並行方法
|
US9708358B2
(en)
|
2000-10-06 |
2017-07-18 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
CA2426686A1
(en)
|
2000-10-30 |
2002-07-18 |
Sequenom, Inc. |
Method and apparatus for delivery of submicroliter volumes onto a substrate
|
EP1548130B1
(de)
*
|
2000-11-15 |
2012-01-18 |
Third Wave Technologies, Inc. |
FEN Endonukleasen
|
JP4860098B2
(ja)
*
|
2000-12-18 |
2012-01-25 |
ダイアックス、コープ |
遺伝的パッケージの焦点を合わせたライブラリー
|
KR20020063359A
(ko)
*
|
2001-01-27 |
2002-08-03 |
일렉트론 바이오 (주) |
핵산 및 올리거뉴클레오티드의 상보적 이중결합의 특정서열에 특이적으로 반응하는 절단기법을 이용한 핵산 혼성분석 방법 및 장치
|
WO2002073158A2
(en)
*
|
2001-03-09 |
2002-09-19 |
Apollo Biotechnology, Inc. |
Conjugate probes and optical detection of analytes
|
AU2013205033B2
(en)
*
|
2001-04-17 |
2016-06-09 |
Takeda Pharmaceutical Company Limited |
Novel Methods of Constructing Libraries Comprising Displayed and/or Expressed Members of a Diverse Family of Peptides, Polypeptides or Proteins and the Novel Libraries
|
US6534646B2
(en)
*
|
2001-06-04 |
2003-03-18 |
Barrskogen, Inc. |
Oligonucleotide labeling reagents
|
US6893822B2
(en)
|
2001-07-19 |
2005-05-17 |
Nanogen Recognomics Gmbh |
Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
|
US20050147984A1
(en)
*
|
2001-08-31 |
2005-07-07 |
Clondiag Chip Technologies Gmbh |
Interaction detection on several probe arrays
|
US20030170678A1
(en)
*
|
2001-10-25 |
2003-09-11 |
Neurogenetics, Inc. |
Genetic markers for Alzheimer's disease and methods using the same
|
US20030224380A1
(en)
*
|
2001-10-25 |
2003-12-04 |
The General Hospital Corporation |
Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
|
WO2003054143A2
(en)
*
|
2001-10-25 |
2003-07-03 |
Neurogenetics, Inc. |
Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
|
GB0129012D0
(en)
*
|
2001-12-04 |
2002-01-23 |
Solexa Ltd |
Labelled nucleotides
|
US7057026B2
(en)
*
|
2001-12-04 |
2006-06-06 |
Solexa Limited |
Labelled nucleotides
|
DE10201463B4
(de)
|
2002-01-16 |
2005-07-21 |
Clondiag Chip Technologies Gmbh |
Reaktionsgefäß zur Durchführung von Array-Verfahren
|
US7074597B2
(en)
*
|
2002-07-12 |
2006-07-11 |
The Trustees Of Columbia University In The City Of New York |
Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
|
US20040067532A1
(en)
|
2002-08-12 |
2004-04-08 |
Genetastix Corporation |
High throughput generation and affinity maturation of humanized antibody
|
US11008359B2
(en)
|
2002-08-23 |
2021-05-18 |
Illumina Cambridge Limited |
Labelled nucleotides
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
DK3587433T3
(da)
|
2002-08-23 |
2020-05-18 |
Illumina Cambridge Ltd |
Modificerede nukleotider
|
DE60330182D1
(de)
*
|
2002-09-08 |
2009-12-31 |
Applera Corp |
Festphasengebundene PNA-Dimere und deren Synthese
|
US20050032081A1
(en)
*
|
2002-12-13 |
2005-02-10 |
Jingyue Ju |
Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
|
ES2524048T3
(es)
|
2003-03-31 |
2014-12-03 |
F. Hoffmann-La Roche Ag |
Composiciones y métodos para la detección de ciertos flavivirus, incluidos los miembros del serogrupo del virus de la encefalitis japonesa
|
US7158353B2
(en)
*
|
2003-11-06 |
2007-01-02 |
Seagate Technology Llc |
Magnetoresistive sensor having specular sidewall layers
|
US7667024B2
(en)
*
|
2003-11-19 |
2010-02-23 |
Allelogic Biosciences Corp. |
Oligonucleotides labeled with a plurality of fluorophores
|
WO2005084272A2
(en)
*
|
2004-02-28 |
2005-09-15 |
Wang Chang-Ning J |
Nucleic acid complexes
|
EP2436778A3
(de)
*
|
2004-03-03 |
2012-07-11 |
The Trustees of Columbia University in the City of New York |
Photospaltbare fluoreszierende Nukleotide zur DNA-Sequenzierung auf einem durch ortsspezifische Kopplungschemie konstruierten Chip
|
WO2006073436A2
(en)
*
|
2004-04-29 |
2006-07-13 |
The Trustees Of Columbia University In The City Of New York |
Mass tag pcr for multiplex diagnostics
|
US7939251B2
(en)
|
2004-05-06 |
2011-05-10 |
Roche Molecular Systems, Inc. |
SENP1 as a marker for cancer
|
WO2005118871A1
(en)
*
|
2004-05-28 |
2005-12-15 |
The Arizona Board Of Regents |
Surface plasmon resonance sensor for detecting changes in polynucleotides mass
|
US7828954B2
(en)
*
|
2004-09-21 |
2010-11-09 |
Gamida For Life B.V. |
Electrode based patterning of thin film self-assembled nanoparticles
|
EP1672082B1
(de)
*
|
2004-10-08 |
2009-12-16 |
Sysmex Corporation |
Verfahren zum Nachweis einer Zielsubstanz unter Verwendung einer Nukleinsäuresonde
|
JP2008520616A
(ja)
*
|
2004-11-24 |
2008-06-19 |
アプラーゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング |
固相ペプチド合成および精製方法
|
EP2239342A3
(de)
|
2005-02-01 |
2010-11-03 |
AB Advanced Genetic Analysis Corporation |
Reagentien, Verfahren und Bibliotheken zur Sequenzierung mit Kügelchen
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
US9169510B2
(en)
*
|
2005-06-21 |
2015-10-27 |
The Trustees Of Columbia University In The City Of New York |
Pyrosequencing methods and related compositions
|
GB0517097D0
(en)
*
|
2005-08-19 |
2005-09-28 |
Solexa Ltd |
Modified nucleosides and nucleotides and uses thereof
|
CA2630544A1
(en)
*
|
2005-11-21 |
2007-05-31 |
The Trustees Of Columbia University In The City Of New York |
Multiplex digital immuno-sensing using a library of photocleavable mass tags
|
KR100652903B1
(ko)
*
|
2005-12-21 |
2006-12-04 |
한국과학기술연구원 |
초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
|
CN101495654A
(zh)
*
|
2006-04-19 |
2009-07-29 |
阿普里拉股份有限公司 |
无凝胶珠基测序的试剂、方法和文库
|
US7674924B2
(en)
|
2006-05-22 |
2010-03-09 |
Third Wave Technologies, Inc. |
Compositions, probes, and conjugates and uses thereof
|
WO2008042067A2
(en)
|
2006-09-28 |
2008-04-10 |
Illumina, Inc. |
Compositions and methods for nucleotide sequencing
|
GB2457402B
(en)
|
2006-12-01 |
2011-10-19 |
Univ Columbia |
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
|
US20090017562A1
(en)
*
|
2007-03-13 |
2009-01-15 |
Iowa State University Research Foundation, Inc. |
Raman-active reagents
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
CA2964398C
(en)
*
|
2007-09-14 |
2023-03-07 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
WO2009039122A2
(en)
|
2007-09-17 |
2009-03-26 |
Sequenom, Inc. |
Integrated robotic sample transfer device
|
EP2209911B1
(de)
|
2007-10-19 |
2013-10-16 |
The Trustees of Columbia University in the City of New York |
Dna-sequenzierung mit reversiblen nicht-fluoreszenz-nukleotid-terminatoren und mit einer spaltbaren markierung modifizierten nukleotidterminatoren und eine deoxyinosineverbindung mit einer reversiblen terminatorgruppe
|
US20110014611A1
(en)
|
2007-10-19 |
2011-01-20 |
Jingyue Ju |
Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequences by synthesis
|
US20090215050A1
(en)
|
2008-02-22 |
2009-08-27 |
Robert Delmar Jenison |
Systems and methods for point-of-care amplification and detection of polynucleotides
|
WO2009114815A1
(en)
*
|
2008-03-13 |
2009-09-17 |
Dyax Corp |
Libraries of genetic packages comprising novel hc cdr3 designs
|
JP5651022B2
(ja)
*
|
2008-03-15 |
2015-01-07 |
ホロジック,インコーポレーテッド |
増幅反応中の核酸分子を分析するための組成物及び方法
|
US9388510B2
(en)
|
2008-04-24 |
2016-07-12 |
Dyax Corp. |
Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs
|
US8208909B2
(en)
|
2008-06-02 |
2012-06-26 |
West Corporation |
System, apparatus and method for availing a mobile call of address information
|
EP2478136A4
(de)
*
|
2009-09-14 |
2013-09-25 |
Dyax Corp |
Bibliotheken aus genetischen packungen mit neuen hc-cdr3-entwürfen
|
CA2787483C
(en)
*
|
2010-02-12 |
2018-03-06 |
Saint Louis University |
Molecular biosensors capable of signal amplification
|
EP2561098B1
(de)
*
|
2010-04-23 |
2015-09-09 |
Australian Centre for Plant Functional Genomics Pty Ltd. |
Durch verankerte enzyme vermittelte nukleinsäureerkennung
|
US9354228B2
(en)
|
2010-07-16 |
2016-05-31 |
Adimab, Llc |
Antibody libraries
|
KR20130042033A
(ko)
|
2010-09-20 |
2013-04-25 |
주식회사 씨젠 |
단일-표지 고정화 프로브 및 엑소핵산 절단 활성을 이용한 고상에서의 타겟 핵산서열 검출
|
CN110564819A
(zh)
|
2011-05-19 |
2019-12-13 |
基纳生物技术有限公司 |
用于多重核酸鉴定的产品和方法
|
EP3388442A1
(de)
|
2013-03-15 |
2018-10-17 |
Illumina Cambridge Limited |
Modifizierte nukleoside oder nukleotide
|
WO2014144883A1
(en)
|
2013-03-15 |
2014-09-18 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
EP3722442B1
(de)
|
2013-08-05 |
2023-04-05 |
Twist Bioscience Corporation |
De-novo-synthetisierte genbanken
|
US10669304B2
(en)
|
2015-02-04 |
2020-06-02 |
Twist Bioscience Corporation |
Methods and devices for de novo oligonucleic acid assembly
|
WO2016172377A1
(en)
|
2015-04-21 |
2016-10-27 |
Twist Bioscience Corporation |
Devices and methods for oligonucleic acid library synthesis
|
CN114350766A
(zh)
|
2015-04-24 |
2022-04-15 |
基纳生物技术有限公司 |
检测和定量次要变体的并行式方法
|
US10233489B2
(en)
|
2015-04-24 |
2019-03-19 |
Agena Bioscience, Inc. |
Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
|
KR20180050411A
(ko)
|
2015-09-18 |
2018-05-14 |
트위스트 바이오사이언스 코포레이션 |
올리고핵산 변이체 라이브러리 및 그의 합성
|
CN113604546A
(zh)
|
2015-09-22 |
2021-11-05 |
特韦斯特生物科学公司 |
用于核酸合成的柔性基底
|
CN108603307A
(zh)
|
2015-12-01 |
2018-09-28 |
特韦斯特生物科学公司 |
功能化表面及其制备
|
GB2568444A
(en)
|
2016-08-22 |
2019-05-15 |
Twist Bioscience Corp |
De novo synthesized nucleic acid libraries
|
JP6871364B2
(ja)
*
|
2016-09-21 |
2021-05-12 |
ツイスト バイオサイエンス コーポレーション |
核酸に基づくデータ保存
|
WO2018066713A1
(ja)
*
|
2016-10-07 |
2018-04-12 |
地方独立行政法人神奈川県立産業技術総合研究所 |
核酸の検出方法及びそのためのキット
|
WO2018112426A1
(en)
|
2016-12-16 |
2018-06-21 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
CN110892485A
(zh)
|
2017-02-22 |
2020-03-17 |
特韦斯特生物科学公司 |
基于核酸的数据存储
|
US10894959B2
(en)
|
2017-03-15 |
2021-01-19 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
CA3066744A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
WO2018231864A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
KR20200047706A
(ko)
|
2017-09-11 |
2020-05-07 |
트위스트 바이오사이언스 코포레이션 |
Gpcr 결합 단백질 및 이의 합성 방법
|
CN111565834B
(zh)
|
2017-10-20 |
2022-08-26 |
特韦斯特生物科学公司 |
用于多核苷酸合成的加热的纳米孔
|
SG11202006460SA
(en)
|
2018-01-04 |
2020-08-28 |
Twist Bioscience Corp |
Dna-based digital information storage
|
SG11202011467RA
(en)
|
2018-05-18 |
2020-12-30 |
Twist Bioscience Corp |
Polynucleotides, reagents, and methods for nucleic acid hybridization
|
WO2020176680A1
(en)
|
2019-02-26 |
2020-09-03 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for antibody optimization
|
SG11202109322TA
(en)
|
2019-02-26 |
2021-09-29 |
Twist Bioscience Corp |
Variant nucleic acid libraries for glp1 receptor
|
US11332738B2
(en)
|
2019-06-21 |
2022-05-17 |
Twist Bioscience Corporation |
Barcode-based nucleic acid sequence assembly
|