DE3817603A1 - Extracorporeal hyperthermia device - Google Patents

Extracorporeal hyperthermia device

Info

Publication number
DE3817603A1
DE3817603A1 DE3817603A DE3817603A DE3817603A1 DE 3817603 A1 DE3817603 A1 DE 3817603A1 DE 3817603 A DE3817603 A DE 3817603A DE 3817603 A DE3817603 A DE 3817603A DE 3817603 A1 DE3817603 A1 DE 3817603A1
Authority
DE
Germany
Prior art keywords
blood
hyperthermia device
extracorporeal hyperthermia
extracorporeal
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE3817603A
Other languages
German (de)
Other versions
DE3817603C2 (en
Inventor
Michael Stieglitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STIEGLITZ, MICHAEL, 6473 GEDERN, DE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE3817603A priority Critical patent/DE3817603A1/en
Publication of DE3817603A1 publication Critical patent/DE3817603A1/en
Application granted granted Critical
Publication of DE3817603C2 publication Critical patent/DE3817603C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/369—Temperature treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/366—General characteristics of the apparatus related to heating or cooling by liquid heat exchangers

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

In summary, the device can be described as a unit which permits the hyperthermal healing method to be carried out outside the body of the patient to be treated and in which only blood is treated thermally.

Description

Die Erfindung betrifft ein Gerät nach dem Oberbegriff des Anspruchs zu 1. und 2.The invention relates to a device according to the preamble of claims to 1. and 2.

Das unter Anspruch zu 1 u. 2 beschriebene Gerät gehört derzeit erkennbar nicht zu dem medizinischen Stand der Technik.That under claim to 1 u. 2 described device belongs currently not recognizable regarding the medical status of the technique.

Die konventionelle Hyperthermie-Therapie gilt als anerkanntes medizinisches Heilverfahren, bei dem mittels Kurzwelle oder Bädern nach Schlenz eine thera­ peutisch erwünschte, partielle Erhöhung der Körper­ temperatur, wodurch thermolabile Erreger bei verschied­ enen Infektionskrankheiten geschwächt bzw. abgetötet werden, bewirkt wird.Conventional hyperthermia therapy is considered recognized medical treatment, in which a short wave or baths according to Schlenz a thera partially desired increase of the body temperature, causing thermolabile pathogens in various infectious diseases weakened or killed be effected.

Die bisherigen physikalischen Hyperthermie-Verfahren durch Bäder bzw. Kurzwelle belasten in starkem Maße den gesamten Organismus, so daß es eine Anzahl von Kontraindikationen zu beachten galt, insbesondere viele Herz- und Kreislauferkrankungen, aber auch ver­ schiedene path. Veränderungen am Bewegungs- und Stütz­ apparat sowie einige Hauterkrankungen.The previous physical hyperthermia procedures polluted by baths or short waves to a great extent  the whole organism, making it a number of Contraindications had to be considered, especially many cardiovascular diseases, but also ver divorced path. Changes in movement and support apparatus as well as some skin diseases.

Durch die Behandlung mit dem Gerät nach dem Oberbe­ griff des Anspruchs zu 1 wird einerseits die Anwendung der Hyperthermie standardisiert und einfach abzu­ stimmen, andererseits fällt die thermische Belastung des Organismus gänzlich weg, so daß praktisch keine Kontraindikationen mehr bestehen. Des weiteren kann bei entsprechender Behandlungsdauer das Blut nicht nur partiell, sondern fast vollständig der thermischen Behandlung ausgesetzt werden. Bei dem Gerät nach dem Oberbegriff des Anspruchs zu 2 kann das Blut gleich­ zeitig extrakorporal uv-bestrahlt werden, was die Behandlung zu einer Art "physikalischem Antibiotikum" ohne unumgänglich Neben- und Wechselwirkungen eines chemischen Antibiotikums werden läßt.By treatment with the device after Oberbe on the one hand, the application standardized and easy to remove hyperthermia correct, on the other hand the thermal load drops of the organism completely, so that practically none Contraindications exist more. Furthermore, with the appropriate duration of treatment, the blood does not only partially, but almost completely thermal Be suspended. For the device after The preamble of claim 2 can equal the blood be extracorporeally UV-irradiated at an early stage, Treatment for a kind of "physical antibiotic" without inevitable side effects and interactions chemical antibiotic.

Bei der nachfolgenden technischen Beschreibung des Gerätes wird ergänzend auf die anliegende technische Zeichnung Bezug genommen (Anlage 3).In the following technical description of the Device is complementary to the attached technical Drawing referred (Appendix 3).

Die Verbindung zwischen Gerät und Patient wird ent­ weder durch sie sog. Cimino-Fistel (Shunt zw. Art. radialis und V. cephalica antebrachii) oder über beide Arme (links an Art. radialis, rechts an Cubitalvene) hergestellt. Bei Eintritt in das Gerät wird das Blut heparinisiert und durchläuft eine Blutpumpe, wobei die Durchlaufmenge nicht über 15 ml/min. liegen darf. Das Blut durchläuft in einer Kunststoff-Schlauchspirale den Wärmetauscher A, dessen Thermiköl-Füllung mittels der durch den Temperatur­ fühler und Schaltthermostat A gesteuerten Heizsprirale A regelbar auf 40-47 Grad C erwärmt wird. Im Anschluß an diese Erwärmung durchläuft das Blut zur Temperatur- Rückführung den Wärmetauscher B, dessen über den Tem­ peraturfühler und Schaltthermostat B gesteuerte Heiz­ sprirale das Thermiköl auf 37-38 Grad C erwärmt. Dieser Wärmetauscher B wird getrennt schaltbar sein, falls eine Senkung der Temperatur auf die physio­ logischen Normalwerte therapeutisch unzweckmäßig ist. Ein nachgeschalteter elektronischer Thermostat mit elektromagnetischem Absperrventil gewährleistet, daß auch bei Ausfall einer der vorgeschalteten Tempera­ turfühler u./o. Schaltthermostate kein übermäßig er­ wärmtes Blut zurückgeführt wird. Das Blut wird weiter durch einen Flachbehälter geführt, der bei entprechen­ der Indikation mit UV-Licht bestrahlt werden kann; der Flachbehälter dient hierbei zur Vergrößerung der Bestrahlungsfläche. Danach ist ein handelsüblicher Luftfänger mit Ventil geschaltet, der der Vermeidung von Lufteinschlüssen im Blut dient und somit der Gefahr einer Luftembolie wirksam vorbeugt. Eine weitere, danach geschaltete Vorrichtung ermöglicht vor der Reinfusion die Einleitung von Medikamenten, O2 oder zur Volumensubstitution über einen handelsüblichen Luer-Anschluß.The connection between the device and the patient is established either through so-called cimino fistula (shunt between art. Radialis and V. cephalica antebrachii) or via both arms (left to art. Radialis, right to cubital vein). When entering the device, the blood is heparinized and passed through a blood pump, the flow rate not exceeding 15 ml / min. may lie. The blood passes through the heat exchanger A, the thermal oil filling is heated by means of the sensor by the temperature and switching thermostat controlled Heizsprirale A A regulated to 40-47 degrees C in a plastic tube spiral. Following this warming, the blood passes through the heat exchanger B for temperature feedback, the heat sensor controlled by the temperature sensor and switching thermostat B heating the thermal oil to 37-38 degrees C. This heat exchanger B will be switchable separately if a lowering of the temperature to the normal physiological values is therapeutically inappropriate. A downstream electronic thermostat with an electromagnetic shut-off valve ensures that even if one of the upstream temperature sensors u./o. Switching thermostats do not return excessively warmed blood. The blood is passed through a flat container, which can be irradiated with UV light if the indication corresponds. the flat container serves to enlarge the radiation area. A commercially available air trap with a valve is then switched on, which serves to avoid air pockets in the blood and thus effectively prevents the risk of air embolism. Another device switched on afterwards enables the introduction of medication, O 2 or for volume substitution via a commercially available Luer connection before reinfusion.

Claims (2)

1. Medizinisch-technische Vorrichtung zur Durchführung einer extrakorporalen Hyperthermie-Therapie, dadurch gekennzeichnet, menschliches Blut über eine Arterie entnommen, in einem geschlossenen Kreislauf auf bis zu 47 Grad C erhitzt und vor der Rückführung in den Körper durch eine Vene auf normale Körpertem­ peratur heruntergekühlt wird.1. Medical-technical device for carrying out extracorporeal hyperthermia therapy, characterized in that human blood is drawn via an artery, heated in a closed circuit to up to 47 degrees C and cooled down to normal body temperature through a vein before being returned to the body becomes. 2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß bei Bedarf das Blut zu­ sätzlich mit UV-Licht bestrahlt werden kann.2. Device according to claim 1, characterized in that if necessary the blood too can also be irradiated with UV light.
DE3817603A 1988-05-24 1988-05-24 Extracorporeal hyperthermia device Granted DE3817603A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3817603A DE3817603A1 (en) 1988-05-24 1988-05-24 Extracorporeal hyperthermia device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3817603A DE3817603A1 (en) 1988-05-24 1988-05-24 Extracorporeal hyperthermia device

Publications (2)

Publication Number Publication Date
DE3817603A1 true DE3817603A1 (en) 1989-11-30
DE3817603C2 DE3817603C2 (en) 1992-12-24

Family

ID=6355005

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3817603A Granted DE3817603A1 (en) 1988-05-24 1988-05-24 Extracorporeal hyperthermia device

Country Status (1)

Country Link
DE (1) DE3817603A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3279B (en) 1993-05-19 1995-05-25 Kanapenas Rimantas Mykolas Apparatus for purification of biological fluid from toxical material and virus
WO1996009843A1 (en) * 1994-09-26 1996-04-04 Microwave Medical Systems, Inc. Heat treatment for viral inactivation
US5588959A (en) * 1994-08-09 1996-12-31 University Of Washington Hemodialysis recirculation measuring method
DE19531935A1 (en) * 1995-08-17 1997-02-20 Panagiotis Tsolkas Device for whole body hyperthermia treatment
EP0773035A3 (en) * 1995-11-09 1997-11-12 Fresenius Medical Care Deutschland GmbH Method and apparatus for determining hemodynamic variables during extracorporal blood treatment
DE29719537U1 (en) * 1997-11-04 1997-12-18 Jostra Medizintechnik Ag Temperature regulating device
US5954659A (en) * 1996-02-16 1999-09-21 Curley; Michael G. Method and apparatus for invasively measuring cardiac output by detecting temperature differences of blood heated by radiation
WO2004009137A2 (en) * 2002-07-18 2004-01-29 Clearant, Inc. Methods for sterilizing biological materials by irradiation over a temperature gradient
LT5397B (en) 2005-03-23 2007-01-25 Rimantas KANAPĖNAS Mini multipurpose medical laser apparatus
US7848487B2 (en) 2001-09-24 2010-12-07 Clearant, Inc. Methods for sterilizing biological materials containing non-aqueous solvents
LT5996B (en) 2012-06-21 2014-02-25 Mykolas Rimantas KANAPĖNAS Portable laser device for treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2822167A1 (en) * 1977-05-31 1978-12-21 Parks Leon C METHOD AND DEVICE FOR CONDUCTING A FEVER TREATMENT
DE3624511A1 (en) * 1985-01-08 1987-05-07 Dresden Praecitronic Cuvette for irradiation of biological fluids by means of ultraviolet light
DD247846A1 (en) * 1983-11-23 1987-07-22 Ilmenau Tech Hochschule DEVICE FOR THERAPEUTICALLY EFFECTIVE ULTRAVIOLET RADIATION HEPARINIZED BLOOD

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2822167A1 (en) * 1977-05-31 1978-12-21 Parks Leon C METHOD AND DEVICE FOR CONDUCTING A FEVER TREATMENT
DD247846A1 (en) * 1983-11-23 1987-07-22 Ilmenau Tech Hochschule DEVICE FOR THERAPEUTICALLY EFFECTIVE ULTRAVIOLET RADIATION HEPARINIZED BLOOD
DE3624511A1 (en) * 1985-01-08 1987-05-07 Dresden Praecitronic Cuvette for irradiation of biological fluids by means of ultraviolet light

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DE-Z: Deutsche med. Wschr. 108/1983, S. 504-509 *
DE-Z: Medizinal-Markt/ACTA Mediotechnica, 19. Jg., Nr. 1/1971,S. 2-7 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3279B (en) 1993-05-19 1995-05-25 Kanapenas Rimantas Mykolas Apparatus for purification of biological fluid from toxical material and virus
US5588959A (en) * 1994-08-09 1996-12-31 University Of Washington Hemodialysis recirculation measuring method
WO1996009843A1 (en) * 1994-09-26 1996-04-04 Microwave Medical Systems, Inc. Heat treatment for viral inactivation
DE19531935A1 (en) * 1995-08-17 1997-02-20 Panagiotis Tsolkas Device for whole body hyperthermia treatment
WO1997006839A1 (en) * 1995-08-17 1997-02-27 Panagiotis Tsolkas Apparatus for hyperthermic treatment of the whole body
EP0773035A3 (en) * 1995-11-09 1997-11-12 Fresenius Medical Care Deutschland GmbH Method and apparatus for determining hemodynamic variables during extracorporal blood treatment
US5866015A (en) * 1995-11-09 1999-02-02 Fresenius Ag Method for determining hemodynamic parameters during an extracorporeal hemotherapy and related device
US5954659A (en) * 1996-02-16 1999-09-21 Curley; Michael G. Method and apparatus for invasively measuring cardiac output by detecting temperature differences of blood heated by radiation
DE29719537U1 (en) * 1997-11-04 1997-12-18 Jostra Medizintechnik Ag Temperature regulating device
US7848487B2 (en) 2001-09-24 2010-12-07 Clearant, Inc. Methods for sterilizing biological materials containing non-aqueous solvents
WO2004009137A2 (en) * 2002-07-18 2004-01-29 Clearant, Inc. Methods for sterilizing biological materials by irradiation over a temperature gradient
WO2004009137A3 (en) * 2002-07-18 2004-06-17 Clearant Inc Methods for sterilizing biological materials by irradiation over a temperature gradient
LT5397B (en) 2005-03-23 2007-01-25 Rimantas KANAPĖNAS Mini multipurpose medical laser apparatus
LT5996B (en) 2012-06-21 2014-02-25 Mykolas Rimantas KANAPĖNAS Portable laser device for treatment

Also Published As

Publication number Publication date
DE3817603C2 (en) 1992-12-24

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: STIEGLITZ, MICHAEL, 6473 GEDERN, DE

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee