DE3751422T2 - Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten. - Google Patents

Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten.

Info

Publication number
DE3751422T2
DE3751422T2 DE3751422T DE3751422T DE3751422T2 DE 3751422 T2 DE3751422 T2 DE 3751422T2 DE 3751422 T DE3751422 T DE 3751422T DE 3751422 T DE3751422 T DE 3751422T DE 3751422 T2 DE3751422 T2 DE 3751422T2
Authority
DE
Germany
Prior art keywords
mononuclear
cells
subclasses
immune system
activation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751422T
Other languages
English (en)
Other versions
DE3751422D1 (de
Inventor
Jeffrey E Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lymphocyte Kinetics Inc Chicago Ill Us
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE3751422D1 publication Critical patent/DE3751422D1/de
Publication of DE3751422T2 publication Critical patent/DE3751422T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G01N2015/016—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
DE3751422T 1986-08-12 1987-08-12 Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten. Expired - Lifetime DE3751422T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89575486A 1986-08-12 1986-08-12
PCT/US1987/001948 WO1988001385A1 (en) 1986-08-12 1987-08-12 Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system

Publications (2)

Publication Number Publication Date
DE3751422D1 DE3751422D1 (de) 1995-08-24
DE3751422T2 true DE3751422T2 (de) 1995-12-14

Family

ID=25405027

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751422T Expired - Lifetime DE3751422T2 (de) 1986-08-12 1987-08-12 Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten.

Country Status (7)

Country Link
US (3) US5445939A (de)
EP (1) EP0319543B1 (de)
JP (1) JP2769156B2 (de)
AT (1) ATE125361T1 (de)
CA (1) CA1296622C (de)
DE (1) DE3751422T2 (de)
WO (1) WO1988001385A1 (de)

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CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
AT392481B (de) * 1989-04-18 1991-04-10 Keplinger Klaus Verfahren zum nachweis fuer die anwesenheit von aids-viren im menschlichen organismus
CA2011099A1 (en) * 1989-04-19 1990-10-19 Stephen C. Wardlaw Determination of lymphocyte reactivity to specific antigens in blood
SE9501782D0 (sv) * 1995-05-12 1995-05-12 Landstinget I Oestergoetland Method of predicting the therapeutic response of a drug against a malignant tumour
US5846758A (en) * 1995-11-30 1998-12-08 His Excellency Ghassan I. Shaker Method for diagnosing autoimmune diseases
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5774482A (en) * 1996-04-30 1998-06-30 Sun Microsystems, Inc. Apparatus and method for processing errors associated with data transfers in a computer
US6014904A (en) * 1996-05-09 2000-01-18 Becton, Dickinson And Company Method for classifying multi-parameter data
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
EP0907412B1 (de) 1996-06-28 2008-08-27 Caliper Life Sciences, Inc. Hochdurchsatz-screening-testsystem mittels mikrofluidischer vorrichtungen
US7514232B2 (en) 1996-12-06 2009-04-07 Becton, Dickinson And Company Method for detecting T cell response to specific antigens in whole blood
US6285377B1 (en) * 1997-06-26 2001-09-04 Bayer Corporation Method and apparatus for generating a smooth normalized star diagram
WO1999006811A2 (en) * 1997-08-01 1999-02-11 Derek Nigel John Hart Method for counting dendritic cells
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
WO2000011476A1 (en) * 1998-08-25 2000-03-02 The Immune Response Corporation Methods for evaluating immune function
CN1140801C (zh) * 2000-03-01 2004-03-03 胡军 检测血液中淋巴细胞对特定抗原反应性的方法
JP2004501358A (ja) 2000-05-11 2004-01-15 ベクトン・ディキンソン・アンド・カンパニー 最適な境界を有する平滑化された多角形を使用して散布図中のクラスタを識別するシステム
WO2003008537A2 (en) 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
EP1752160A3 (de) 2001-04-06 2007-05-30 Mannkind Corporation Epitop-Sequenzen
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
US7476514B2 (en) 2002-04-11 2009-01-13 Cylex, Inc. Method for monitoring the immune response and predicting clinical outcomes in transplant recipients
WO2004015070A2 (en) * 2002-08-08 2004-02-19 Baylor College Of Medicine Isolation and identification of t cells
JP2005537800A (ja) * 2002-09-06 2005-12-15 マンカインド コーポレイション エピトープ配列
CN101146550B (zh) * 2004-12-29 2013-04-17 曼康公司 免疫原性组合物用于制备引发和增强免疫应答的试剂盒的用途
JP4649231B2 (ja) * 2005-02-28 2011-03-09 株式会社カネカ フローサイトメータ、細胞の解析方法、細胞解析プログラム、蛍光検出器の感度設定方法および陽性率判定法における基準ゲート設定方法
PL2420833T3 (pl) * 2006-05-05 2016-03-31 Opexa Therapeutics Szczepionka z komórek T
US20090062237A1 (en) * 2007-06-15 2009-03-05 Mayo Foundation For Medical Education And Research Evaluating immune competence
CA2764678C (en) 2009-06-04 2017-12-12 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
JP6047870B2 (ja) 2011-10-14 2016-12-21 ソニー株式会社 ３ｄデータ解析のための装置、方法及びプログラムと、微小粒子解析システム
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US10458976B2 (en) 2014-04-08 2019-10-29 Satish Deshpande Early warning of changes in health and robustness using narrowly forward scattered light to track ease of morphological changes of blood cells
US20150285738A1 (en) * 2014-04-08 2015-10-08 Satish Deshpande Early warning of changes in health and robustness using narrowly forward scattered light to track ease of morphological changes of blood cells
WO2016063364A1 (ja) * 2014-10-22 2016-04-28 株式会社日立ハイテクノロジーズ 細胞計測機構及びそれを有する細胞培養装置並びに細胞計測方法
WO2019177152A1 (ja) 2018-03-16 2019-09-19 Ｋｏｔａｉバイオテクノロジーズ株式会社 免疫実体の効率的クラスタリング
JP6796737B1 (ja) * 2020-06-02 2020-12-09 振武 曽 多項目自動血球計数装置

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US4381295A (en) * 1979-04-26 1983-04-26 Ortho Pharmaceutical Corporation Monoclonal antibody to human helper T cells and methods of preparing same
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
US4492752A (en) * 1982-09-03 1985-01-08 Ortho Diagnostics Systems Inc. Method for discriminating between unstained and absorbing dye stained cells
US4607007A (en) * 1983-04-07 1986-08-19 Becton, Dickinson And Company Differentiation of natural killer cell subpopulations of cells
US4599304A (en) * 1983-10-07 1986-07-08 Becton, Dickinson And Company Method for monitoring activated cell subpopulations
US4701408A (en) * 1984-01-30 1987-10-20 Smithkline Beckman Corporation Monoclonal antibody to activated macrophages
US4677061A (en) * 1984-10-19 1987-06-30 Genetic Systems Corporation T-cell lymphocyte subset monitoring of immunologic disease
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4778750A (en) * 1986-02-19 1988-10-18 Imreg, Inc. Diagnostic methods for immune function
CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
ES2061965T3 (es) * 1988-01-21 1994-12-16 Becton Dickinson Co Un anticuerpo monoclonal util para revelar la activacion de leucocitos.

Also Published As

Publication number Publication date
AU615880B2 (en) 1991-10-17
US5445939A (en) 1995-08-29
JP2769156B2 (ja) 1998-06-25
EP0319543A1 (de) 1989-06-14
EP0319543A4 (de) 1990-01-08
ATE125361T1 (de) 1995-08-15
WO1988001385A1 (en) 1988-02-25
AU7851187A (en) 1988-03-08
JPH02500297A (ja) 1990-02-01
EP0319543B1 (de) 1995-07-19
DE3751422D1 (de) 1995-08-24
US5656446A (en) 1997-08-12
CA1296622C (en) 1992-03-03
US5843689A (en) 1998-12-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LYMPHOCYTE KINETICS INC., CHICAGO, ILL., US

8381 Inventor (new situation)

Free format text: ANDERSON, JEFFREY E., CHICAGO, ILL., US