DE3479294D1 - Applicator for the non-invasive transcutaneous delivery of medicament - Google Patents

Applicator for the non-invasive transcutaneous delivery of medicament

Info

Publication number
DE3479294D1
DE3479294D1 DE8484109840T DE3479294T DE3479294D1 DE 3479294 D1 DE3479294 D1 DE 3479294D1 DE 8484109840 T DE8484109840 T DE 8484109840T DE 3479294 T DE3479294 T DE 3479294T DE 3479294 D1 DE3479294 D1 DE 3479294D1
Authority
DE
Germany
Prior art keywords
applicator
medicament
transcutaneous delivery
invasive transcutaneous
layers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484109840T
Other languages
English (en)
Inventor
Den Sibalis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drug Delivery Systems Inc
Original Assignee
Drug Delivery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery Systems Inc filed Critical Drug Delivery Systems Inc
Application granted granted Critical
Publication of DE3479294D1 publication Critical patent/DE3479294D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
DE8484109840T 1983-08-18 1984-08-17 Applicator for the non-invasive transcutaneous delivery of medicament Expired DE3479294D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/524,252 US4557723A (en) 1983-08-18 1983-08-18 Applicator for the non-invasive transcutaneous delivery of medicament

Publications (1)

Publication Number Publication Date
DE3479294D1 true DE3479294D1 (en) 1989-09-14

Family

ID=24088425

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484109840T Expired DE3479294D1 (en) 1983-08-18 1984-08-17 Applicator for the non-invasive transcutaneous delivery of medicament

Country Status (10)

Country Link
US (1) US4557723A (de)
EP (1) EP0147524B1 (de)
JP (1) JPS6060860A (de)
KR (1) KR930005050B1 (de)
AT (1) ATE45290T1 (de)
AU (1) AU563137B2 (de)
BR (1) BR8404119A (de)
CA (1) CA1224993A (de)
DE (1) DE3479294D1 (de)
MX (1) MX158181A (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
WO1986007269A1 (en) * 1985-06-10 1986-12-18 Drug Delivery Systems Inc. Programmable control and mounting system for transdermal drug applicator
US5135477A (en) * 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
GB2175207B (en) * 1985-05-20 1989-07-05 Nabil Ibraham Rizk Improvements in or relating to implantable electrophoretic pumps
ATE50915T1 (de) * 1985-06-10 1990-03-15 Drug Delivery Systems Inc Anlage und verfahren zur steuerung der elektrokinetischen lieferungsgeschwindigkeit einer arznei.
DE3533230A1 (de) * 1985-09-18 1987-03-26 Ruediger Prof Dr Groening Transdermale arzneiformen mit verbesserter biologischer verfuegbarkeit der wirkstoffe
JPH066171B2 (ja) * 1985-11-15 1994-01-26 美智士 谷 生薬を使用した電気的刺激治療装置
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
AU597890B2 (en) * 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4915685A (en) * 1986-03-19 1990-04-10 Petelenz Tomasz J Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange
US4886489A (en) * 1986-03-19 1989-12-12 Jacobsen Stephen C Flow-through methods and apparatus for iontophoresis application of medicaments at a controlled pH
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
JPS62268569A (ja) * 1986-05-19 1987-11-21 株式会社アドバンス イオントフオレ−ゼ用リザ−バ電極
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4911688A (en) * 1986-07-15 1990-03-27 Patent Research And Development Corp. Fluid containing covers - with electrical circuits
US4734090A (en) * 1986-07-18 1988-03-29 Drug Delivery Systems Inc. Electrical transdermal drug applicator
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
JPS63102768A (ja) * 1986-10-20 1988-05-07 山之内製薬株式会社 イオントフオレ−シス用の新規プラスタ−構造体
JPS63135179A (ja) * 1986-11-26 1988-06-07 立花　俊郎 薬物の経皮投与具
US4822334A (en) * 1986-12-04 1989-04-18 Robert Tapper Electrical dosimetry control system
US4940456A (en) * 1987-02-10 1990-07-10 Dan Sibalis Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5163899A (en) * 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
CA1317522C (en) * 1987-03-20 1993-05-11 Dan Sibalis Transdermal drug delivery system
US4787888A (en) * 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
JPH0197475A (ja) * 1987-10-09 1989-04-14 Watanabe Wataru 電気治療器
ATE131081T1 (de) * 1988-01-21 1995-12-15 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
JP2907342B2 (ja) * 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア イオン滲透非侵襲的サンプリングまたは送出装置
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5162042A (en) * 1988-07-05 1992-11-10 Alza Corporation Electrotransport transdermal system
US4978337A (en) * 1988-09-08 1990-12-18 Alza Corporation Formulation chamber with exterior electrotransport delivery device
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
WO1990004434A1 (en) * 1988-10-26 1990-05-03 Kabushiki Kaisya Advance Interface for electric endermism
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
IT1224045B (it) * 1988-12-29 1990-09-26 Alberico Benedicenti Veicolatore elettronico portatile
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
ES2095929T3 (es) * 1989-10-23 1997-03-01 Theratech Inc Dispositivo iontoforetico que emplea un regulador del regimen.
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US6004309A (en) * 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
ES2082973T3 (es) * 1990-03-30 1996-04-01 Alza Corp Dispositivo para administracion iontoforetica de farmacos.
ATE251929T1 (de) * 1990-03-30 2003-11-15 Alza Corp Vorrichtung zur iontophoretischen verabreichung
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5160741A (en) * 1990-07-06 1992-11-03 Alza Corporation Reduction or prevention of skin irritation by drugs
US5130139A (en) * 1990-07-06 1992-07-14 Alza Corporation Reduction or prevention of skin irritation by drugs
US5087241A (en) * 1990-07-24 1992-02-11 Empi, Inc. Iontophoresis electrode with reservoir and injection site
US5120545A (en) * 1990-08-03 1992-06-09 Alza Corporation Reduction or prevention of sensitization to drugs
US5149539A (en) * 1990-08-03 1992-09-22 Alza Corporation Reduction or prevention of sensitization to drugs
US5380271A (en) * 1992-09-24 1995-01-10 Alza Corporation Electrotransport agent delivery device and method
FR2709670B1 (fr) * 1993-09-10 1995-10-20 Asulab Sa Dispositif en trois modules pour l'administration transdermique de médicaments par électrophorèse ou iontophorèse.
JP2818999B2 (ja) * 1993-11-22 1998-10-30 ドラッグ デリバリー システムズ インコーポレイテッド 経皮薬剤アプリケータ
DE69513672T3 (de) * 1994-09-30 2007-09-06 Vyteris, Inc. (n.d.Ges.d. Staates Delaware) Verbesserte vorrichtung zur iontophoretischen verabreichung von medikamenten
EP0920345A4 (de) * 1996-06-19 2006-05-10 Vyteris Inc Iontophoretische abscheidung von zelladhäsions-inhibitoren
HUP0004589A3 (en) 1997-06-30 2003-08-28 Centre Nat Rech Scient Improved method for transferring nucleic acid into the striped muscle and combination therefor
BR9810372A (pt) 1997-06-30 2000-09-05 Rhone Poulenc Rorer Sa Processo de transferência de ácido nucléico para o interior de células de organismos eucarióticos pluricelulares in vivo, composição, ácido nucléico e campo elétrico, e, produto de combinação
US6163720A (en) * 1997-12-18 2000-12-19 Alza Corporation Layered rate controlling membranes for use in an electrotransport device
RU2323017C2 (ru) * 2001-10-24 2008-04-27 Пауэр Пэйпер Лтд. Устройство и способ контролируемой доставки активных веществ в кожу
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
JP4721902B2 (ja) * 2003-12-26 2011-07-13 久光製薬株式会社 用時活性化型イオントフォレーシスデバイス
WO2005084257A2 (en) * 2004-02-26 2005-09-15 Vpn Solutions, Llc Composite thin-film glucose sensor
US8386029B2 (en) 2005-03-31 2013-02-26 Encore Medical Asset Corporation Apparatus for electrotherapy drug delivery with added impurities
US9072476B2 (en) * 2005-09-23 2015-07-07 Medtronic Minimed, Inc. Flexible sensor apparatus
CA2935569A1 (en) * 2006-04-13 2007-10-25 Teva Pharmaceuticals International Gmbh Transdermal methods and systems for the delivery of anti-migraine compounds
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
EP2494932B1 (de) 2007-06-22 2020-05-20 Ekos Corporation Vorrichtung zur Behandlung von intrakranialen Blutungen
EP2644228A1 (de) * 2007-06-27 2013-10-02 The General Hospital Corporation Verfahren und Vorrichtung zur optischen Unterdrückung der photodynamischen Therapie
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US7981106B2 (en) * 2008-02-26 2011-07-19 Pinchas Gilad Electronically-controlled device for release of drugs, proteins, and other organic or inorganic chemicals
EP2100850A1 (de) 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Mikronadelarray und Verfahren zur Mikronadelherstellung
FR2950802B1 (fr) 2009-10-02 2012-02-03 Sartorius Stedim Biotech Sa Elaboration et/ou conservation d'un produit biopharmaceutique.
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
US9950143B2 (en) 2012-02-07 2018-04-24 Marie Andrea I. Wilborn Intravenous splint cover and associated methods
US20130204190A1 (en) * 2012-02-07 2013-08-08 Marie-Andrea I. Wilborn Intravenous splint cover and associated methods
USD790071S1 (en) * 2015-10-19 2017-06-20 Mölnlycke Health Care Ab Wound dressing
EP3307388B1 (de) 2015-06-10 2022-06-22 Ekos Corporation Ultraschallkatheter
CN109289116A (zh) * 2018-09-28 2019-02-01 胡希龙 养生保健护腰

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US588479A (en) * 1897-08-17 Atjguste roedel
US486902A (en) * 1892-11-29 Galvanic body-battery
US385567A (en) * 1888-07-03 Chables d
US385556A (en) * 1888-07-03 Medicated electric belt
US2493155A (en) * 1947-01-09 1950-01-03 Mine Safety Appliances Co Apparatus for treating skin diseases
US2667162A (en) * 1950-05-03 1954-01-26 Zwahlen Henry Device permitting the ambulatory ionization of blood circulatory troubles of the lower limbs
US2784715A (en) * 1953-03-25 1957-03-12 Kestler Otto Colman Cataphoresis unit
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US3289671A (en) * 1963-09-11 1966-12-06 Troutman Edwin Glenn Iontophoresis method
US3547107A (en) * 1968-02-27 1970-12-15 Robert L Chapman Chest mounted heart tachycardia detector
US4008721A (en) * 1975-04-14 1977-02-22 Medtronic, Inc. Tape electrode for transmitting electrical signals through the skin
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus
US4273135A (en) * 1977-08-19 1981-06-16 Minnesota Mining And Manufacturing Company Biomedical electrode
US4239046A (en) * 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4243052A (en) * 1979-01-08 1981-01-06 Stimtech, Inc. Disposable electrode
DE2902183A1 (de) * 1979-01-20 1980-07-31 Geb Schmidt Beate D Ringwelski Vorrichtung zum aufbringen bzw. halten von nitrit- und/oder nitratverbindungen auf der haut
US4314554A (en) * 1979-07-16 1982-02-09 Greatbatch W Tissue growth control apparatus and method
US4367745A (en) * 1980-05-27 1983-01-11 Minnesota Mining And Manufacturing Company Conformable electrically conductive compositions
US4419091A (en) * 1981-02-12 1983-12-06 Sybron Corporation Metalized medical treatment electrode with insulated edge
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
EP0060452B1 (de) * 1981-03-05 1985-10-23 Medtronic, Inc. Iontotherapeutisches Gerät
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
JPS58130054A (ja) * 1982-01-29 1983-08-03 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体

Also Published As

Publication number Publication date
KR850001702A (ko) 1985-04-01
BR8404119A (pt) 1985-07-16
MX158181A (es) 1989-01-13
ATE45290T1 (de) 1989-08-15
CA1224993A (en) 1987-08-04
EP0147524A1 (de) 1985-07-10
JPH0456627B2 (de) 1992-09-09
AU3185084A (en) 1985-02-21
AU563137B2 (en) 1987-06-25
KR930005050B1 (ko) 1993-06-15
JPS6060860A (ja) 1985-04-08
EP0147524B1 (de) 1989-08-09
US4557723A (en) 1985-12-10

Similar Documents

Publication Publication Date Title
DE3479294D1 (en) Applicator for the non-invasive transcutaneous delivery of medicament
AU591738B2 (en) Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
AR241261A1 (es) Mejoras en un aplicador para la administracion sub-cutanea no invasiva de medicamentos.
US4196737A (en) Transcutaneous electrode construction
DE3475692D1 (en) Drug delivery device
US3518984A (en) Packaged diagnostic electrode device
NZ220016A (en) Transdermal drug delivery system with drug reservoir(s), adhesive layer(s) and flexible backing layer
EP0293893A3 (de) Wegwerfbare und/oder wiederauffüllbare Medikamentenapplikatoren und Anfertigungsverfahren dafür
DK0521988T3 (da) Anordning til iontoforetisk lægemiddeltilførsel
MY103355A (en) Active substance-containing plaster of the controlled administration of active substances to the skin, the use thereof and a process for the controlled administration of active substances to the skin
DE3173564D1 (en) Subcutaneously implantable lead with drug dispenser means
NL187788C (nl) Elektrotherapie-inrichting voor niet-invasieve elektrische stimulatie van het menselijk lichaam.
HUT53542A (en) Therapeutical system effecting through skin
DE3271718D1 (de) Bioelectrode
GB1335530A (en) Implantable electric device
EP0749763A3 (de) Transdermaler Wirkstoffapplikator und Elektroden hierfür
ES8101878A1 (es) Perfeccionamientos en electrodos pasivos en acoplamiento ca-pacitivo
EP0138551A3 (de) System zur transdermalen Abgabe von Nitroglycerin
AU3683484A (en) The use of menthol to enhance transdermal drug delivery
GB2190289B (en) Applicators for applying medicated liquids to the skin
ES2007849A6 (es) Aplicadores de medicamentos transdermicos desechables yno rellenables y metodo de fabricacion de los mismos.
ZA856428B (en) Adhesive transdermal dosage layer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT

8339 Ceased/non-payment of the annual fee