DE3277816D1 - Inclusion complexes of n-(1-phenylethyl)-3,3-diphenylpropylamine respectively the hydrochloride thereof with cyclodextrin, a process for the preparation of these inclusion complexes as well as pharmaceutical preparations containing these inclusion complexes - Google Patents

Inclusion complexes of n-(1-phenylethyl)-3,3-diphenylpropylamine respectively the hydrochloride thereof with cyclodextrin, a process for the preparation of these inclusion complexes as well as pharmaceutical preparations containing these inclusion complexes

Info

Publication number
DE3277816D1
DE3277816D1 DE8282901423T DE3277816T DE3277816D1 DE 3277816 D1 DE3277816 D1 DE 3277816D1 DE 8282901423 T DE8282901423 T DE 8282901423T DE 3277816 T DE3277816 T DE 3277816T DE 3277816 D1 DE3277816 D1 DE 3277816D1
Authority
DE
Germany
Prior art keywords
inclusion complexes
diphenylpropylamine
cyclodextrin
phenylethyl
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282901423T
Other languages
English (en)
Inventor
Jozsef Dr Szejtli
Agnes Dr Stadler
Maria Dr Vikmon
Dezso Dr Korbonits
Sandor Dr Virag
Istvan Turcsan
Pal Dr Kiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of DE3277816D1 publication Critical patent/DE3277816D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
DE8282901423T 1981-05-12 1982-05-12 Inclusion complexes of n-(1-phenylethyl)-3,3-diphenylpropylamine respectively the hydrochloride thereof with cyclodextrin, a process for the preparation of these inclusion complexes as well as pharmaceutical preparations containing these inclusion complexes Expired DE3277816D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU811286A HU183430B (en) 1981-05-12 1981-05-12 Process for producing cyclodextrine inclusion complexes of n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine or n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine-hydrochloride
PCT/HU1982/000024 WO1982004052A1 (en) 1981-05-12 1982-05-12 Method for the preparation of inclusion complexes derived from n-(1-phenyle-ethyle)-3,3-diphenyle-propylamine respectively from the hydrochloryde thereof and from cyclodextrine

Publications (1)

Publication Number Publication Date
DE3277816D1 true DE3277816D1 (en) 1988-01-21

Family

ID=10953697

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282901423T Expired DE3277816D1 (en) 1981-05-12 1982-05-12 Inclusion complexes of n-(1-phenylethyl)-3,3-diphenylpropylamine respectively the hydrochloride thereof with cyclodextrin, a process for the preparation of these inclusion complexes as well as pharmaceutical preparations containing these inclusion complexes

Country Status (6)

Country Link
US (1) US4518588A (de)
EP (1) EP0078820B1 (de)
DE (1) DE3277816D1 (de)
FI (1) FI67390C (de)
HU (1) HU183430B (de)
WO (1) WO1982004052A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3372705D1 (en) * 1982-04-30 1987-09-03 Takeda Chemical Industries Ltd Pharmaceutical composition and its use
JPS60202115A (ja) * 1984-03-27 1985-10-12 Ichiro Shibauchi エポキシ樹脂用硬化剤
HU193933B (en) * 1984-06-08 1987-12-28 Nitrokemia Ipartelepek Herbicide or plant growth stimulating agent comprising beta-cyclodextrin complex of benzolsulphonylurea derivative and process for preparing the active substances
IL76889A0 (en) * 1984-11-02 1986-02-28 Johnson Matthey Plc Solubilised platinum compound,method for the production thereof and pharmaceutical compositions containing the same
EP0261719A3 (de) * 1986-09-23 1990-10-10 Akzo N.V. Thermochemischlumineszierende Komplexe von Cyclodextrinen
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
US4877774A (en) * 1987-09-09 1989-10-31 The United States Of America As Represented By The Department Of Health And Human Services Administration of steroid hormones
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
WO1989006978A1 (en) * 1988-02-05 1989-08-10 Schering Aktiengesellschaft Berlin Und Bergkamen Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
KR100251995B1 (ko) * 1991-08-23 2000-06-01 젠센 제임스 유. 칼슘 수용체 활성 분자
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
ZA955582B (en) * 1994-07-06 1996-02-26 Group Services Proprietary Lim Inclusion complexes of ranitidine
EP1275635A1 (de) 1994-10-21 2003-01-15 Nps Pharmaceuticals, Inc. Kalzium-Rezeptor aktive Verbindungen
ATE352537T1 (de) 1996-05-01 2007-02-15 Nps Pharma Inc Verbindungen, die auf anorganische ionen- rezeptoren wirken
DE60117777T2 (de) * 2000-05-11 2006-08-17 Eastman Chemical Co., Kingsport Acylierte zyclodextrin guest-inklusion komplexe

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553191A (en) * 1968-05-21 1971-01-05 Cpc International Inc Aminoethyl cyclodextrin and method of making same
JPS52121084A (en) * 1976-04-05 1977-10-12 Morogata Naoya Cyclodextrin inclusion compound and process for preparting the same
HU176215B (en) * 1978-01-27 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1
US4352793A (en) * 1979-04-26 1982-10-05 Sumitomo Chemical Company, Limited Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
US4407795A (en) * 1981-07-16 1983-10-04 American Cyanamid Company Inclusion compound of p-hexadecylamino benzoic acid in cyclodextrin and method of use

Also Published As

Publication number Publication date
HU183430B (en) 1984-05-28
FI67390B (fi) 1984-11-30
EP0078820A1 (de) 1983-05-18
FI830011A0 (fi) 1983-01-03
FI67390C (fi) 1985-03-11
US4518588A (en) 1985-05-21
EP0078820A4 (de) 1984-11-23
WO1982004052A1 (en) 1982-11-25
FI830011L (fi) 1983-01-03
EP0078820B1 (de) 1987-12-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: LOTTERHOS, H., DIPL.-ING. DR.-ING. BARTSCH, E., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 6000 FRANKFURT

8339 Ceased/non-payment of the annual fee