DE3062332D1 - Multilayer column chromatography specific binding assay method, test device and test kit - Google Patents

Multilayer column chromatography specific binding assay method, test device and test kit

Info

Publication number
DE3062332D1
DE3062332D1 DE8080103191T DE3062332T DE3062332D1 DE 3062332 D1 DE3062332 D1 DE 3062332D1 DE 8080103191 T DE8080103191 T DE 8080103191T DE 3062332 T DE3062332 T DE 3062332T DE 3062332 D1 DE3062332 D1 DE 3062332D1
Authority
DE
Germany
Prior art keywords
species
ligand
binding
bed
column chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080103191T
Other languages
English (en)
Inventor
Judith Feingers
Anthony Joseph Pick
Daniel B Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ames Yissum Ltd
Original Assignee
Ames Yissum Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ames Yissum Ltd filed Critical Ames Yissum Ltd
Application granted granted Critical
Publication of DE3062332D1 publication Critical patent/DE3062332D1/de
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/524—Physical parameters structural properties
    • G01N2030/528—Monolithic sorbent material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
DE8080103191T 1979-06-21 1980-06-09 Multilayer column chromatography specific binding assay method, test device and test kit Expired DE3062332D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/050,543 US4301139A (en) 1979-06-21 1979-06-21 Multilayer column chromatography specific binding assay method, test device and test kit

Publications (1)

Publication Number Publication Date
DE3062332D1 true DE3062332D1 (en) 1983-04-21

Family

ID=21965858

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080103191T Expired DE3062332D1 (en) 1979-06-21 1980-06-09 Multilayer column chromatography specific binding assay method, test device and test kit

Country Status (8)

Country Link
US (1) US4301139A (de)
EP (1) EP0021214B1 (de)
JP (1) JPS566163A (de)
AT (1) ATE2807T1 (de)
AU (1) AU516431B2 (de)
CA (1) CA1140465A (de)
DE (1) DE3062332D1 (de)
IL (1) IL60104A (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
IL56839A0 (en) * 1979-03-11 1979-05-31 Technion Res & Dev Foundation Improvement in specific binding assay technique
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
JPS5782766A (en) * 1980-11-11 1982-05-24 Konishiroku Photo Ind Co Ltd Amynological measuring element
US4425438A (en) 1981-03-13 1984-01-10 Bauman David S Assay method and device
NZ201901A (en) * 1981-09-25 1986-11-12 Commw Serum Lab Commission An apparatus suitable for performing automated heterogeneous immunoassays in a plurality of samples
US5141875A (en) * 1982-01-08 1992-08-25 Environmental Diagnostics, Inc. Rotary fluid manipulator
US5496520A (en) * 1982-01-08 1996-03-05 Kelton; Arden A. Rotary fluid manipulator
US4938927A (en) * 1982-01-08 1990-07-03 Environmental Diagnostics, Inc. Rotary fluid manipulator
JPS58144743A (ja) * 1982-02-23 1983-08-29 Japan Exlan Co Ltd 活性度の異なるゲルの効率的な併用方法
US4487681A (en) * 1983-01-17 1984-12-11 Chemcut Corporation Electroplating test cell
GB8305197D0 (en) * 1983-02-24 1983-03-30 Amersham Int Plc Assay methods
US4666866A (en) * 1983-04-19 1987-05-19 Krauth Gary H Immunoassay for antigens employing supported binder
US4552839A (en) * 1983-08-01 1985-11-12 Syntex (U.S.A.) Inc. Determination of analytes in particle-containing medium
USRE34405E (en) * 1983-08-01 1993-10-12 Abbott Laboratories Determination of analytes in particle-containing medium
US4522923A (en) * 1983-10-03 1985-06-11 Genetic Diagnostics Corporation Self-contained assay method and kit
US4786471A (en) * 1983-10-21 1988-11-22 Baxter Travenol Laboratories, Inc. Heterogeneous immunoassay method and assembly
DE3342627A1 (de) * 1983-11-25 1985-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Immunchemischer schnelltest
JPS60235060A (ja) * 1984-05-08 1985-11-21 Dai Ichi Pure Chem Co Ltd 放射性物質を利用した迅速免疫測定法
DE3484505D1 (de) * 1983-12-19 1991-05-29 Daiichi Pure Chemicals Co Ltd Immuntest.
JPS60133368A (ja) * 1983-12-19 1985-07-16 Dai Ichi Pure Chem Co Ltd 免疫測定方法
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
US4740306A (en) * 1986-03-17 1988-04-26 Temple University - Of The Commonwealth System Of Higher Education Chromatographic column
US5039488A (en) * 1986-06-06 1991-08-13 Genentech, Inc. Devices for amino acid sequence determination
US5223435A (en) * 1986-06-06 1993-06-29 Genetech, Inc. Amino acid sequence determination with mobile peptide
DE3643760A1 (de) * 1986-12-20 1988-06-23 Boehringer Mannheim Gmbh Verfahren zur anreicherung und/oder isolierung von herzglykosiden unter verwendung unpolarer adsorberharze
IL84939A (en) * 1987-01-06 1991-05-12 Baylor College Medicine Chemically inert wafer for synthesizing biopolymers
US4787971A (en) * 1987-01-23 1988-11-29 Alan Donald Miniaturized column chromatography separation apparatus and method of assaying biomolecules employing the same
DE560410T1 (de) 1987-04-27 2001-12-20 Unilever Nv Testgerät zur Durchführung von spezifischen Bindungsprüfungen.
JPH02504188A (ja) * 1987-07-02 1990-11-29 イン・ヴィトロ・テクノロジーズ・インコーポレイテッド 複数分析の免疫検定用毛細管装置
ATE111604T1 (de) * 1989-01-30 1994-09-15 Epitope Inc Avidin-biotin assistiertes immunassayverfahren.
US6352862B1 (en) 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
US5433847A (en) * 1989-11-01 1995-07-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Radial flow chromatography
WO1991013998A1 (en) * 1990-03-12 1991-09-19 Biosite Diagnostics, Inc. Bioassay device with non-absorbent textured capillary surface
US5998220A (en) 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
US5877028A (en) 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US5316680A (en) * 1992-10-21 1994-05-31 Cornell Research Foundation, Inc. Multimodal chromatographic separation media and process for using same
WO1995019569A1 (en) * 1994-01-13 1995-07-20 Abion Beteiligungs- Und Verwaltungsgesellschaft Mbh Reaction columns for simultaneous multiple measurement and method
US5585070A (en) * 1994-04-29 1996-12-17 Phoenix International Life Sciences Inc. Method for extraction, extraction cartridge and automated extraction processing system
US5522994A (en) * 1995-02-01 1996-06-04 Cornell Research Foundation, Inc. Single column chromatographic determination of small molecules in mixtures with large molecules
CA2230802C (en) * 1995-09-01 2008-04-01 Ortho-Clinical Diagnostics, Inc. Analytical element and method for the determination of a specific binding ligand using a vanadium bromoperoxidase as a signal-generating enzyme
US5879951A (en) * 1997-01-29 1999-03-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing unidirectional flow
US5939252A (en) * 1997-05-09 1999-08-17 Lennon; Donald J. Detachable-element assay device
US7067264B2 (en) * 2001-07-23 2006-06-27 Bagaria Padma S Test device for detecting human blood and method of use
US7270959B2 (en) 2001-07-25 2007-09-18 Oakville Hong Kong Company Limited Specimen collection container
US7300633B2 (en) 2001-07-25 2007-11-27 Oakville Hong Kong Company Limited Specimen collection container
CN100528363C (zh) * 2002-02-13 2009-08-19 安捷伦科技有限公司 微流体分离柱装置及其制备方法
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7619819B2 (en) * 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
CA2499046A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
AU2003267192A1 (en) 2002-09-12 2004-04-30 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7560272B2 (en) 2003-01-04 2009-07-14 Inverness Medical Switzerland Gmbh Specimen collection and assay container
CA2527054C (en) * 2003-06-25 2013-01-08 Peregrine Pharmaceuticals, Inc. Methods and apparatus for continuous large-scale radiolabeling of proteins
JP4931584B2 (ja) * 2003-07-14 2012-05-16 ウオーターズ・テクノロジーズ・コーポレイシヨン 一体型ガードカラムをもつ分離装置
US7028536B2 (en) * 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US7517495B2 (en) 2003-08-25 2009-04-14 Inverness Medical Switzerland Gmbh Biological specimen collection and analysis system
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
ATE459933T1 (de) 2004-11-16 2010-03-15 Illumina Inc Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
DE102005024154B3 (de) * 2005-05-23 2007-02-08 Bischoff Analysentechnik und -geräte GmbH Elemente zur Trennung von Substanzen durch Verteilung zwischen einer stationären und einer mobilen Phase und Verfahren zur Herstellung einer Trennvorrichtung
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
WO2008140616A2 (en) * 2006-12-21 2008-11-20 Hammersmith Imanet Limited Nucleophilic radiofluorination using microfabricated devices
US20080166792A1 (en) * 2007-01-05 2008-07-10 Attar Amir J Detection of analytes in materials liquids using capillary colorimetric detection
US8283169B1 (en) * 2007-03-21 2012-10-09 Allan Yang Wu Differential gradient separation of cells
DE102007025311A1 (de) 2007-05-30 2008-12-04 Senova Gesellschaft für Biowissenschaft und Technik mbH Quantitativer heterogener schneller Bindungsassay mit breitem dynamischen Bereich und einfacher photometrischer Detektion
CA2721409A1 (en) * 2008-04-25 2009-10-29 Can Ozbal Separation cartridges and methods for fabrication and use thereof
EP2283349A1 (de) * 2008-04-29 2011-02-16 Becton, Dickinson & Company Verfahren und system zur messung einer probe für die bestimmung des vorliegens und gegebenenfalls behandlung eines krankheitszustands
CN102213717A (zh) * 2010-04-02 2011-10-12 王立莉 免疫纳米粒子层析测定方法及实施该方法的装置
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
JP6443714B2 (ja) * 2013-08-29 2018-12-26 高砂熱学工業株式会社 蒸気生成装置、吸着材収容器、及び蒸気生成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3659104A (en) * 1970-06-29 1972-04-25 Univ Jerusalem The Method of measuring serum thyroxine
US3823001A (en) * 1971-05-06 1974-07-09 Bio Rad Laboratories Determination of thyroid hormone uptake
IL42105A (en) * 1973-04-25 1976-08-31 Yissum Res Dev Co Process for determination of triiodothyronine
US3925017A (en) * 1973-05-01 1975-12-09 Wisconsin Alumni Res Found Preparation of dry, porous gel particles having high water regain for liquid sampling
US3941564A (en) * 1973-09-13 1976-03-02 Miles Laboratories, Inc. Method for assessing thyroid function
SE388694B (sv) * 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
US4151254A (en) * 1975-06-16 1979-04-24 Union Carbide Corporation Adsorption columns for use in radioimmunoassays
US4094647A (en) * 1976-07-02 1978-06-13 Thyroid Diagnostics, Inc. Test device
IL51354A (en) * 1977-01-28 1979-07-25 Ames Yissum Ltd Assay method for the quantitative determination of a hapten in aqueous solution
US4189304A (en) * 1978-10-27 1980-02-19 Miles Laboratories, Inc. Device and method for detecting myoglobin

Also Published As

Publication number Publication date
AU5881780A (en) 1981-03-12
EP0021214B1 (de) 1983-03-16
US4301139A (en) 1981-11-17
ATE2807T1 (de) 1983-04-15
IL60104A (en) 1983-03-31
AU516431B2 (en) 1981-06-04
EP0021214A1 (de) 1981-01-07
JPS566163A (en) 1981-01-22
CA1140465A (en) 1983-02-01

Similar Documents

Publication Publication Date Title
DE3062332D1 (en) Multilayer column chromatography specific binding assay method, test device and test kit
SE7714931L (sv) Forfarande och anordning for specifika bindningstest med tillhorande kolonnkromatografering
ES8607556A1 (es) Procedimiento para detectar y determinar un analito con pro-piedades de fijacion bioafines en una muestra liquida
Wall Thin-layer chromatography: a modern practical approach
AU720394B2 (en) Opposable-element assay device employing conductive barrier
JPS6463865A (en) Solid phase immunoassay
FI954591A (fi) Vastakkain asetettavilla elementeillä varustettu kromatografinen määrityslaite
KR830009486A (ko) 물질의 분석방법 및 장치
GB1489913A (en) Method and device for the quantitative determination of a substance having a specific binding affinity for another substance
FI863454A (fi) Multizonanalysanordning med koncentrationszon foer en maerkt reagens.
EP0271854A3 (en) Test strip for the analytical determination of body fluid constituents
GB1356847A (en) Methods of and apparatus for measuring the amount of a component in a biological fluid
JPS6432169A (en) Immunochromatograph method using colloidal particle
DK11186A (da) Fremgangsmaade og apparat til immunanalyser
DE3065997D1 (en) Enzyme-immuno assay for the detection of pathogen specific antibodies and test-kit for performing this assay
KR940005955A (ko) 고체상 분석
EP0279097A3 (de) Teststreifen für Immunassay
SE8700949D0 (sv) Adsorbent for affinitetskromatografi
IL74144A (en) Method of detecting biological substances in a fluid sample by contact with solid surface carrying material with affinity for said substance
ES2070834T3 (es) Estuche de ensayo para la determinacion de un analito en heces.
EP0394021A3 (de) Diagnostische Vorrichtung mit einem porösen, absorbierenden Einzelelement
Camag Considerations on the reproducibility of thin-layer chromatographic separations
Smith et al. Thin layer chromatography
Power High performance liquid chromatography in biopharmaceutical analysis using column switching techniques
Yang et al. Dual-column miniseparator to separate alpha-fetoprotein from fibrinogen and immunoglobulin

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee