DE141967C - - Google Patents

Description

IMPERIAL

PATENT OFFICE.

The observation was made that neutral, water-soluble high-proofs can be obtained from gelatoses Silver compounds can win, in which the silver is masked and firmly bound and which because of this property are therapeutically valuable; they contain up to 20 percent and more silver.

Gelatoses are understood to mean: cleavage products of glutin and aldehyde glutin, obtained therefrom by acids or alkalis, by boiling with water at ordinary or increased pressure, in acidic, alkaline or saline solution, through rotting or even through Digestion and which in the literature under the name glutoses (Proto-, Deuterousw. Glutose), glue pepton, glue albumose, semiglutin etc. are known.

To obtain the new silver compounds, the procedure is that the aqueous solution of the gelatoses neutralized, mixed with silver nitrate solution and then evaporated or the silver compounds are precipitated by alcohol or acetone.

When processing larger quantities, it is necessary to evaporate in a very weakly alkaline solution, in order to arrive at a completely neutral end product.

The gelatoses, as they are z. B. Hofmeister describes are more or less acidic reacting compounds. For the extraction of the silver compounds of gelatose it is necessary to add a neutralizing agent to the same to use. As such come z. B. into consideration: alkalis, alkaline reacting salts, organic bases, etc. The same in order to achieve neutralization, with the aid of an indicator, e.g. B. Lakmus, phenolphthalein, rosolic acid, the gelatose solution added.

40

Examples:

I. 100 g of gelatose, obtained from purified glue by heating with pressurized steam of ι 50 ⁰ , are dissolved in 40 g of water on a water bath and made weakly alkaline by 1.1 g of sodium hydrate in 3 ecm of water, so that liquor paper weak, but becomes distinctly blue in color. Then mix with 45 g of silver nitrate in 25 ecm of water. The mixture is brought to dryness in vacuo and contains 19.5 percent silver.

II. 100 g of semiglutin are in 50 g of water dissolved on the water bath and after neutralizing with 0.75 g of sodium hydrate in water mixed with 15 g of silver nitrate in ι ο ecm water. The mixture, brought to dryness in a vacuum, is a powder with a silver content of 8.5 percent.

III. Gelatin is digested in the usual way with pepsin hydrochloric acid, then that becomes Product boiled with freshly precipitated lead oxide, unleaded and evaporated after dialysis. 100 g of this product, further processed according to Example III, give a silver salt with 8.5 percent Silver.

IV. Formaldehyde gelatine is converted into gelatose by boiling with soda solution (1: 10000). 100 g of this product are dissolved in 40 ecm of water with 0.12 g of sodium hydroxide neutralized and with a concentrated

Mixed solution of 25 g of silver nitrate. The mixture brought to dryness contains 12 percent Silver.

The silver salts produced by this process form yellow-white powders, which are dissolve in water with a neutral reaction. 50 percent aqueous solutions are still easy manufacturable. Specific silver reagents, such as dilute hydrochloric acid, saline solution, sulfur-hydrogen, do not give any precipitates with the solutions of the new silver salts. Hexamethylenetetrarnine solution gives a precipitate which dissolves easily in excess of the precipitant. The solution can be easily soluble Evaporate the powder. Urea, piperazine and the like can also be used by evaporation the solutions of the two components produce easily soluble double compounds.

Silver compounds in which the silver is bound in a similar way as in glutinic silver already known and used therapeutically. The previously known products of this Art are either compounds of native protein and silver such as the soluble cascine silver (Argonin) or compounds of albumoses with silver, such as Protargol, and have one Silver content of 4.2 and 7.8 percent. Are added to solutions of argonin or protargol Silver solution, this creates insoluble compounds. It can therefore be derived from the relevant Do not produce silver compounds soluble in protein substances that significantly exceed the specified silver content. Similar the neutral solutions of all protein bodies behave.

In contrast to this, neutral solutions of the gelatoses with silver solutions do not give any precipitates, so that very high percentage can be obtained with great ease and by a much simpler process than with the proteins from the gelatoses Have silver connections made. As in the production of albumose silver the higher silver content of this product compared to the casein silver as a big step forward has been recognized, the superiority of the much higher percentage gelatin silver over the previous silver-protein compounds.

Claims (1)

Patent claim: Process for the preparation of neutrally soluble silver compounds of gelatoses, consisting in neutralizing solutions of gelatoses and adding silver nitrate solution added, then brings the solutions to dryness or the silver compounds by adding alcohol or acetone falls.