DE10199055I2 - Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie. - Google Patents

Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie.

Info

Publication number
DE10199055I2
DE10199055I2 DE2001199055 DE10199055C DE10199055I2 DE 10199055 I2 DE10199055 I2 DE 10199055I2 DE 2001199055 DE2001199055 DE 2001199055 DE 10199055 C DE10199055 C DE 10199055C DE 10199055 I2 DE10199055 I2 DE 10199055I2
Authority
DE
Germany
Prior art keywords
suspensions
disclosed
microsphere suspensions
microbubbles
ultrasound echography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE2001199055
Other languages
English (en)
Other versions
DE10199055I1 (de
Inventor
Michel Schneider
Jean Brochot
Jerome Puginier
Feng Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8212014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10199055(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of DE10199055I1 publication Critical patent/DE10199055I1/de
Publication of DE10199055I2 publication Critical patent/DE10199055I2/de
Active legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225Microparticles, microcapsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
DE2001199055 1992-11-02 1993-10-21 Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie. Active DE10199055I2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810837 1992-11-02
PCT/EP1993/002915 WO1994009829A1 (en) 1992-11-02 1993-10-21 Stable microbubble suspensions as enhancement agents for ultrasound echography

Publications (2)

Publication Number Publication Date
DE10199055I1 DE10199055I1 (de) 2002-08-14
DE10199055I2 true DE10199055I2 (de) 2005-09-29

Family

ID=8212014

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2001199055 Active DE10199055I2 (de) 1992-11-02 1993-10-21 Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie.
DE69307124T Expired - Lifetime DE69307124T2 (de) 1992-11-02 1993-10-21 Stabile mikroblasensuspensionen wie verstärkungagenzien für ultraschall-echographie

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69307124T Expired - Lifetime DE69307124T2 (de) 1992-11-02 1993-10-21 Stabile mikroblasensuspensionen wie verstärkungagenzien für ultraschall-echographie

Country Status (22)

Country Link
US (7) US5445813A (de)
EP (1) EP0619743B1 (de)
JP (1) JP3135919B2 (de)
KR (1) KR100216138B1 (de)
CN (1) CN1069838C (de)
AT (1) ATE146972T1 (de)
AU (3) AU666238B2 (de)
CA (1) CA2125027C (de)
DE (2) DE10199055I2 (de)
DK (1) DK0619743T3 (de)
ES (1) ES2097548T3 (de)
FI (1) FI115953B (de)
GR (1) GR3022826T3 (de)
HU (1) HU227043B1 (de)
IL (1) IL107453A (de)
IS (1) IS1625B (de)
LU (1) LU90837I2 (de)
NL (1) NL300061I2 (de)
NO (1) NO308830B1 (de)
NZ (2) NZ257115A (de)
WO (1) WO1994009829A1 (de)
ZA (1) ZA938117B (de)

Families Citing this family (177)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
CA2154590C (en) * 1993-01-25 2001-06-12 Steven C. Quay Phase shift colloids as ultrasound contrast agents
IL108416A (en) * 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
EP0711179B2 (de) 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
HU225495B1 (en) * 1993-12-15 2007-01-29 Bracco Research Sa Gas mixtures useful as ultrasound contrast media
DE4406474A1 (de) 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
WO2004073750A1 (en) * 1995-06-07 2004-09-02 Harald Dugstad Improvements in or relating to contrast agents
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
ATE238072T1 (de) 1996-02-19 2003-05-15 Amersham Health As Verbesserungen an (oder im bezug auf) kontrastmittel
AU721209B2 (en) * 1996-03-05 2000-06-29 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
DE69736981D1 (de) 1996-05-01 2007-01-04 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US5849727A (en) 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
ES2316157T3 (es) * 1996-08-02 2009-04-01 Ge Healthcare As Mejoras en o relativas a agentes de contraste.
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
WO1998010798A1 (en) 1996-09-11 1998-03-19 Imarx Pharmaceutical Corp. Improved methods for diagnostic imaging using a contrast agent and a vasodilator
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US5962015A (en) * 1997-05-02 1999-10-05 Kobo Products S.A.R.L. Stabilized liposomes
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6726650B2 (en) * 1997-12-04 2004-04-27 Bracco Research S.A. Automatic liquid injection system and method
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE69925461T2 (de) * 1998-02-09 2006-04-27 Bracco International B.V. Zielgerichtete abgabe von biologische-aktive medien
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
US6187665B1 (en) * 1999-01-14 2001-02-13 Lucent Technologies, Inc. Process for deuterium passivation and hot carrier immunity
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
FR2791249B1 (fr) 1999-03-25 2001-06-15 Edap Technomed Milieu de couplage pour ultrasons de puissance
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US6210611B1 (en) * 1999-11-30 2001-04-03 Duke University Methods for producing gas microbubbles having lipid-containing shells formed thereon
AU2001266696A1 (en) 2000-06-02 2001-12-11 Bracco Research Usa Compounds for targeting endothelial cells
DE60223239T2 (de) * 2001-04-06 2008-08-14 Bracco Research S.A. Vorrichtung zur Messung lokaler physikalischer Parameter in einem flüssigkeitsgefüllten Hohlraum
US6855561B2 (en) * 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
SI2301587T1 (sl) 2002-03-01 2014-11-28 Dyax Corp. KDR in VEGF/KDR vezavni peptidi in njihova uporaba pri diagnozi
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
WO2004006964A1 (en) * 2002-07-11 2004-01-22 Targeson, Llc Microbubble compositions, and methods for preparing and using same
KR20050072496A (ko) 2002-11-29 2005-07-11 아머샴 헬스 에이에스 초음파 촬영 방법
ES2352087T3 (es) * 2003-02-04 2011-02-15 Bracco Suisse Sa Agentes de contraste para ultrasonido y procedimiento para la preparación de los mismos.
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
US20060235296A1 (en) 2003-02-13 2006-10-19 Bracco Imaging S.P.A. Contrast enhanced x-ray phase imaging
ES2692166T3 (es) 2003-03-03 2018-11-30 Dyax Corp. Péptidos que se unen específicamente al receptor de HGF (cMet) y usos de los mismos
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
US8021303B2 (en) 2003-06-12 2011-09-20 Bracco Research Sa System for extracting morphological information through a perfusion assessment process
KR101025490B1 (ko) 2003-06-12 2011-04-04 브라코 인터내셔날 비.브이. 초음파 콘트라스트 조영에서 보충 커브 피팅을 통한 혈류 개산
EP1696965B1 (de) * 2003-12-22 2014-12-10 Bracco Suisse SA Anordnung aus gasgefüllten mikrovesikeln mit wirkstoff für die kontrastdarstellung
CN100563718C (zh) * 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
JP4602993B2 (ja) * 2004-01-16 2010-12-22 ボストン サイエンティフィック リミテッド 医用撮像のための方法及び装置
US8708909B2 (en) 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2417080B (en) 2004-08-13 2008-05-21 Stichting Tech Wetenschapp Intravascular ultrasound techniques
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
EP1853333A1 (de) * 2004-12-23 2007-11-14 Bracco Research S.A. Flüssigkeitstransfervorrichtung für medizinische ausgabebehälter
CN100556368C (zh) 2004-12-23 2009-11-04 伯拉考开发股份有限公司 基于弹丸注射的灌注评价方法和系统
WO2006094951A1 (en) 2005-03-03 2006-09-14 Bracco Research Sa Medical imaging system based on a targeted contrast agent
EP1714642A1 (de) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
US8634608B2 (en) 2005-11-10 2014-01-21 Bracco Suisse S.A. Instantaneous visualization of contrast agent concentration in imaging applications
US9198639B2 (en) 2005-11-10 2015-12-01 Bracco Suisse S.A. Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
ES2428964T3 (es) 2005-12-09 2013-11-12 Bracco Suisse Sa Conjugados de vectores específicos de una diana-fosfolípidos
EP1797919A1 (de) * 2005-12-16 2007-06-20 Bracco Research S.A. Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten
CA2659645C (en) 2006-08-01 2015-06-30 Martijn E. Frijlink Pulse inversion sequences for nonlinear imaging
ITBO20060593A1 (it) * 2006-08-04 2008-02-05 Francesca Cavalieri Microbolle realizzate in alcol polivinilico e relativo caricamento delle stesse con ossido di azoto
ATE469660T1 (de) 2006-09-05 2010-06-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden
US8293214B2 (en) * 2006-12-19 2012-10-23 Bracco Suisse S.A. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
CN101605500B (zh) 2006-12-21 2013-01-30 博莱科瑞士股份有限公司 在医学成像应用中对固定造影剂脱离的检测
WO2009083557A1 (en) 2007-12-28 2009-07-09 Bracco Research S.A. Quantification analisys of immobilized contrast agent in medical imaging applications
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
EP2346532B1 (de) 2008-10-07 2020-10-07 Bracco Suisse SA Target-konstrukt mit einem anti-polymer-antikörper und an diesen bindende mikrovesikel
EP2189112A1 (de) 2008-11-24 2010-05-26 Bracco Research S.A. Echzeit-Perfusionsbildgebung und -quantifizierung
JP5341205B2 (ja) 2008-12-16 2013-11-13 ブラッコ・シュイス・ソシエテ・アノニム 造影剤ボーラス投与デバイス
CA2761596C (en) 2009-06-08 2017-11-07 Bracco Suisse S.A. Auto-scaling of parametric images
SG10201403566SA (en) * 2009-08-06 2014-10-30 Sunstar Engineering Inc Composition and process for production thereof
EP2473972B1 (de) 2009-09-01 2019-11-06 Bracco Suisse SA Verfahren zum Erzeugen medizinischer Parameterbilder
EP2335675B1 (de) 2009-12-10 2015-02-18 Neubourg Skin Care GmbH & Co. KG Emulgatorfreie, Polymer-stabilisierte Schaumformulierungen
EP2345732A1 (de) 2010-01-19 2011-07-20 Universite Paris Descartes Verfahren zur intrazellulären Abgabe von Nukleinsäuren
EP2544593B1 (de) 2010-03-09 2014-12-31 Bracco Suisse SA Initialisierung von anpassungsparametern für die perfusionsbeurteilung basierend auf der bolusverabreichung
US20130261535A1 (en) 2010-08-09 2013-10-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods and pharmaceutical compositions for the treatment of an ocular disease in a subject
DK3338807T3 (da) 2010-08-09 2021-02-22 Bracco Suisse Sa Målrettet konstruktion til gasfyldte mikrovesikler
EP2654788B1 (de) 2010-12-24 2018-03-14 Bracco Suisse SA Gasgefüllte mikrovesikel zur verwendung als impfstoff
EP2474327A1 (de) 2011-01-07 2012-07-11 RWTH Aachen Mikrodosierung von Ultraschallkontrastmitteln
AU2012235634B2 (en) 2011-03-28 2017-05-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Sustained-release injectable formulation
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
EP2545908A1 (de) 2011-07-11 2013-01-16 RWTH Aachen Medium für Mikrobläschen oder Mikropartikel und seine Herstellung
KR102166648B1 (ko) 2012-12-21 2020-10-19 브라코 스위스 에스.에이. 시간 경과에 따른 통계 분석에 기초한 영상 진단 애플리케이션에서의 분할
US10010630B2 (en) 2012-12-21 2018-07-03 Bracco Suisse S.A. Gas-filled microvesicles
WO2014140197A1 (en) 2013-03-15 2014-09-18 Westfaelische Wilhelms-Universitaet Muenster Detection of acute renal allograft rejection
BR112015032732B1 (pt) 2013-07-03 2022-05-17 Bracco Suisse S.A. Sistema para tratamento ultrassônico de acidente vascular cerebral
CN106163412B (zh) 2014-04-07 2019-10-11 博莱科瑞士股份有限公司 利用非基频分析对声级进行原位估计
DK3233136T3 (da) 2014-12-18 2019-05-20 Bracco Suisse Sa Formulering med målrettede gasfyldte mikrovesikler
BR112017011881A2 (pt) 2014-12-22 2018-01-02 Bracco Suisse Sa microvesículas cheias com gás para uso como vacina
KR20240005184A (ko) 2014-12-31 2024-01-11 랜티우스 메디컬 이메징, 인크. 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법
WO2017097853A1 (en) 2015-12-09 2017-06-15 Koninklijke Philips N.V. Interleaved beam pattern for sonothrombolysis and other vascular acoustic resonator mediated therapies
WO2017097738A1 (en) 2015-12-10 2017-06-15 Bracco Suisse Sa Detection of immobilized contrast agent with dynamic thresholding
IL260957B2 (en) 2016-02-09 2023-11-01 Bracco Suisse Sa Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
CN107233582B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种基于叔丁醇/水混合溶剂制备超声造影剂的方法
CN115531560A (zh) 2016-05-04 2022-12-30 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10232061B1 (en) 2018-07-06 2019-03-19 Bracco Suisse Sa Freeze-dried formulation for gas-filled microvesicles
CN112165959A (zh) * 2018-07-06 2021-01-01 博莱科瑞士股份有限公司 用于充气微泡的冻干制剂
US10335502B1 (en) 2019-01-29 2019-07-02 Bracco Suisse Sa Freeze-dried formulation for gas-filled microvesicles
CA3120179A1 (en) 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
GB201908352D0 (en) 2019-06-11 2019-07-24 Innovation Ulster Ltd Sonodynamic therapy
US20230057224A1 (en) 2020-02-11 2023-02-23 Bracco Suisse Sa Gas-filled microvesicles for therapeutic use
GB202004629D0 (en) 2020-03-30 2020-05-13 Innovation Ulster Ltd Therapy
US11191888B1 (en) 2020-05-18 2021-12-07 Agitated Solutions Inc. Syringe-based microbubble generator
CN113440627B (zh) * 2021-07-30 2022-11-25 北京诺康达医药科技股份有限公司 一种冻干粉末及其制备方法与应用
CN114177317A (zh) * 2021-11-03 2022-03-15 深圳奥祺生物医药有限公司 一种用于超声造影的微泡冻干制剂、造影剂及制备方法
US11833224B1 (en) 2023-02-08 2023-12-05 Leuvian Llc Lyoprotectant compositions and uses thereof

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US3900420A (en) * 1970-05-18 1975-08-19 Felix Sebba Microgas emulsions and method of forming same
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4256251A (en) * 1978-04-24 1981-03-17 Lawrence M. Smith Surgical staplers and staple
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4587545A (en) * 1978-12-20 1986-05-06 At&T Bell Laboratories High voltage dielectrically isolated remote gate solid-state switch
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4316391A (en) * 1979-11-13 1982-02-23 Ultra Med, Inc. Flow rate measurement
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
DE3324754A1 (de) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen Ultraschallkontrastmittel sowie dessen herstellung
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5283067A (en) * 1987-01-30 1994-02-01 Ciba-Geigy Corporation Parenteral suspensions
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
CH672733A5 (de) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
DE58908194D1 (de) * 1988-02-05 1994-09-22 Schering Ag Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika.
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US5730954A (en) * 1988-08-23 1998-03-24 Schering Aktiengesellschaft Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
DE3934656A1 (de) * 1989-10-13 1991-04-18 Schering Ag Verfahren zur herstellung von waessrigen dispersionen
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
SE465300B (sv) * 1989-12-29 1991-08-26 Sjoeberg John Anitec Ab Anordning vid stickkniv foer urtagning av blod fraan slaktdjur
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
JPH05506031A (ja) * 1990-03-30 1993-09-02 スミスクライン・ビーチャム・コーポレイション 免疫不全ウイルス感染に伴う疾病の抑制
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
DE4127442C2 (de) * 1991-08-17 1996-08-22 Udo Dr Gros Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
EP0605477B2 (de) * 1991-09-17 2007-06-20 GE Healthcare AS Gasförmige ultraschallkontrastmittel
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
CA2148372A1 (en) * 1992-11-02 1994-05-11 Margaret A. Wheatley Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
KR100218642B1 (ko) * 1993-07-02 1999-09-01 스티븐 로손 열변성된 단백질로부터 캡슐화된 마이크로스피어의 제조방법
EP0711179B2 (de) * 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
US5601085A (en) * 1995-10-02 1997-02-11 Nycomed Imaging As Ultrasound imaging

Also Published As

Publication number Publication date
NZ280615A (en) 1997-02-24
US5908610A (en) 1999-06-01
AU3431795A (en) 1996-01-04
DK0619743T3 (da) 1997-01-20
FI115953B (fi) 2005-08-31
FI943167A0 (fi) 1994-07-01
ZA938117B (en) 1994-06-23
IL107453A (en) 1998-01-04
EP0619743A1 (de) 1994-10-19
IS1625B (is) 1996-10-18
CN1069838C (zh) 2001-08-22
AU5336294A (en) 1994-05-24
NZ257115A (en) 1997-06-24
NO308830B1 (no) 2000-11-06
WO1994009829A1 (en) 1994-05-11
NL300061I2 (nl) 2002-02-01
FI943167A (fi) 1994-07-01
CN1088456A (zh) 1994-06-29
NL300061I1 (nl) 2001-12-01
IS4089A (is) 1994-05-03
EP0619743B1 (de) 1997-01-02
AU704954B2 (en) 1999-05-13
NO942476L (no) 1994-06-30
IL107453A0 (en) 1994-02-27
AU681812B2 (en) 1997-09-04
KR940703691A (ko) 1994-12-12
AU666238B2 (en) 1996-02-01
JPH07503254A (ja) 1995-04-06
CA2125027A1 (en) 1994-05-11
US5597549A (en) 1997-01-28
CA2125027C (en) 1998-12-01
LU90837I2 (fr) 2001-11-19
GR3022826T3 (en) 1997-06-30
HUT74561A (en) 1997-01-28
JP3135919B2 (ja) 2001-02-19
US5686060A (en) 1997-11-11
HU9401409D0 (en) 1994-08-29
US6187288B1 (en) 2001-02-13
HU227043B1 (en) 2010-05-28
US20030129137A1 (en) 2003-07-10
DE10199055I1 (de) 2002-08-14
DE69307124T2 (de) 1997-07-17
ES2097548T3 (es) 1997-04-01
US5445813A (en) 1995-08-29
ATE146972T1 (de) 1997-01-15
US20010001279A1 (en) 2001-05-17
NO942476D0 (no) 1994-06-30
KR100216138B1 (ko) 1999-08-16
DE69307124D1 (de) 1997-02-13
AU2618197A (en) 1997-12-18

Similar Documents

Publication Publication Date Title
DE10199055I2 (de) Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie.
EA199800745A1 (ru) Устовершенствования в области контрастных агентов
NZ295744A (en) Frozen suspension of gas bubbles; the liquid suspension being used as an injectable contrast agent
DE69111719T2 (de) Stabile mikroblasensuspensionen zur injektion in lebewesen.
ATE94056T1 (de) Verfahren zur herstellung einer nanoemulsion von oelpartikeln in einer waessrigen phase.
ES2192572T3 (es) Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo.
NO963501L (no) Gassinneholdende mikropartikler, middel inneholdende disse, deres anvendelse ved ultralyddiagnostikk, såvel som fremgangsmåte for fremstilling av partiklene og midlene
MX9706402A (es) EMULSIaN DE GAS ESTABILIZADA, QUE CONTIENE FOSFOLIPIDOS PARA AUMENTAR EL CONTRASTE DEL ULTRASONIDO.