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Publication numberCN1511011 A
Publication typeApplication
Application numberCN 02810549
PCT numberPCT/US2002/011452
Publication date7 Jul 2004
Filing date12 Apr 2002
Priority date13 Apr 2001
Also published asCA2443739A1, CA2443739C, CN1263422C, DE20221877U1, DE60221371D1, DE60221371T2, EP1377210A1, EP1377210A4, EP1377210B1, US6603988, US6701175, US6865412, US7171253, US7725155, US20020151778, US20030083566, US20040152967, US20050137467, US20070100229, US20100274125, WO2002082993A1
Publication number02810549.4, CN 02810549, CN 1511011 A, CN 1511011A, CN-A-1511011, CN02810549, CN02810549.4, CN1511011 A, CN1511011A, PCT/2002/11452, PCT/US/2/011452, PCT/US/2/11452, PCT/US/2002/011452, PCT/US/2002/11452, PCT/US2/011452, PCT/US2/11452, PCT/US2002/011452, PCT/US2002/11452, PCT/US2002011452, PCT/US200211452, PCT/US2011452, PCT/US211452
Inventors坎比泽道拉特肖, 坎比泽・道拉特肖
Applicant凯尔西有限公司
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
Apparatus and method for delivering ablative laser energy and determining volume of tumor mass destroyed
CN 1511011 A
Abstract  translated from Chinese
确定被破坏肿瘤块(40)的体积所用的一种装置和方法,该装置包括一个温度探针(16)和一个激光探针(14),激光探针(14)具有一个温度传感器(15)。 Determining tumor mass destruction (40) of an apparatus and method used for the volume, the apparatus comprises a temperature probe (16) and a laser probe (14), a laser probe (14) having a temperature sensor (15) . 激光探针(14)和温度探针(16)被插入以测量肿瘤块(40)的温度和肿瘤块(40)周围的组织块(38)的温度。 The laser probe (14) and temperature probe (16) is inserted to measure the tumor mass (40) temperature and tumor mass (40) surrounding tissue mass (38) temperature. 通过确定被破坏肿瘤块(40)的体积,则可得到对治疗肿瘤进行监控的图示状况。 By determining the volume of tumor mass destruction (40) can be obtained for the treatment of tumors were shown status monitoring.
Claims(33)  translated from Chinese
  1. 本发明的权利要求如下所述:1、用于确定被破坏肿瘤块体积的一种装置,该装置包括:具有温度传感器的一个激光探针,温度传感器用于测量所述肿瘤块的温度;用于对与肿瘤块相邻的组织温度进行测量一个温度探针;与激光探针和温度探针电动连接的一个计算机控制系统,该计算机控制系统根据肿瘤块温度和组织温度来确定被破坏肿瘤块的体积;与计算机控制系统相连的一个显示器,该显示器对被破坏的肿瘤块体积进行图示性显示。 The rights of the present invention is as follows: 1, an apparatus for determining the volume of tumor mass destroyed, the apparatus comprising: a laser probe having a temperature sensor, a temperature sensor for measuring the temperature of said tumor mass; with of the tumor mass in the tissue adjacent to measure the temperature of a temperature probe; and a computer-controlled system laser probe and temperature probe electric connection, the computer control system based on tumor mass temperature and tissue temperature to determine the destruction of the tumor mass volume; a monitor connected to the computer control system, which monitors the volume of the tumor mass destruction were being illustrative display.
  2. 2.根据权利要求1所述的装置,其中:被破坏肿瘤块的体积的图示性显示包括一个圆形标识。 2. The apparatus according to claim 1, wherein: the destroyed tumor mass volume of illustrative display comprises a circular identification.
  3. 3.根据权利要求1所述的装置,其中:所述图示性显示包括一个球形标识。 3. The apparatus according to claim 1, wherein: said display comprises a spherical illustrative identity.
  4. 4.根据权利要求1所述的装置,其中:所述被破坏肿瘤块的体积的图示性显示被添加到肿瘤块的实际图像上而对被破坏肿瘤块进行即时可视的监控。 4. The apparatus according to claim 1, wherein: the volume of tumor mass destroyed illustration of the display is added to the actual image of the tumor mass and the destruction of tumor mass instant visual monitoring.
  5. 5.根据权利要求4所述的装置,其中:在间隙式激光治疗过程中,对被破坏肿瘤块进行即时的可视性监控。 5. The apparatus according to claim 4, wherein: the gap during the laser treatment of tumor mass destroyed instant visibility monitoring.
  6. 6.根据权利要求1所述的装置,其中:图示性显示还包括温度传感器和温度探针的柱形图。 6. The apparatus according to claim 1, wherein: illustrative display further comprises a temperature sensor and temperature probe bar graph.
  7. 7.根据权利要求1所述的装置,其中:该装置还包括用于接收激光探针的一个激光枪。 7. The apparatus according to claim 1, wherein: the apparatus further includes means for receiving a laser probe of a laser gun.
  8. 8.根据权利要求1所述的装置,其中:该装置还包括用于接收激光探针和温度探针的一个激光枪。 8. The apparatus according to claim 1, wherein: the apparatus further includes means for receiving the laser probe and temperature probe a laser gun.
  9. 9.根据权利要求1所述的装置,其中:激光探针用于接收一根光学纤维以将有效量的激光辐射导入肿瘤块中。 9. The apparatus according to claim 1, wherein: a laser probe for receiving an optical fiber to an effective amount of laser radiation is introduced into the tumor mass.
  10. 10.根据权利要求1所述的装置,其中:激光探针包括用于接收光学纤维的一个金属套管,从而将有效量的激光辐射引入肿瘤块中,而生理液体和麻醉液体之一流入肿瘤块中。 10. The apparatus according to claim 1, wherein: the laser probe comprises an optical fiber for receiving a metal sleeve, so that an effective amount of laser radiation is introduced into a tumor mass, but one of the physiological and anesthetic fluid flows into the liquid tumors block.
  11. 11.根据权利要求1所述的装置,其中:将温度传感器插入与激光探针相分离的肿瘤块中。 11. The apparatus according to claim 1, wherein: the temperature sensor is inserted into the tumor mass and the separation of the probe laser.
  12. 12.根据权利要求1所述的装置,其中:该装置包括一个流体泵以将一定量的液体输入具有一中心温度的肿瘤块中,从而使该中心温度在60℃-100℃之间变化。 12. The apparatus according to claim 1, wherein: the apparatus comprises a fluid pump to a quantity of liquid having a central input temperature of the tumor mass, so that the central temperature between 60 ℃ -100 ℃ change.
  13. 13.用于确定被破坏肿瘤块体积的一种装置,该装置包括:具有一个温度传感器和多个位置标识的一个激光探针,温度传感器用于测量所述肿瘤块的温度;具有多个位置标识的一个温度探针,该温度探针用于对与肿瘤块相邻的组织温度进行测量,所述激光探针和温度探针的位置标识使操作者易于确定激光探针和温度探针之间的相对距离;与激光探针和温度探针电动连接的一个计算机控制系统,该计算机控制系统根据肿瘤块温度和组织温度来确定被破坏肿瘤块的体积;与计算机控制系统相连的一个显示器,该显示器对被破坏的肿瘤块体积进行图示性显示。 13. An apparatus for determining the destruction of tumor mass volume, the apparatus comprising: a laser probe having a temperature sensor and a plurality of location identifier, a temperature sensor for measuring the temperature of said tumor mass; having a plurality of locations A temperature probe is identified, the temperature probe used for tumor mass and adjacent tissue temperature measurement, identifies the location of the laser probe and temperature probe enables the operator to readily determine the laser probe and temperature probe the relative distance between; a computer control system and laser probe and temperature probe electric connection, the computer control system based on tumor mass temperature and tissue temperature to determine the volume of the tumor mass destruction; a monitor connected to the computer control system, The display of the destruction of the tumor mass volume was illustrative display.
  14. 14.根据权利要求13所述的装置,其中:所述位置标识沿着激光探针和温度探针中的每一个的至少一部分长度以相等的距离相互间隔。 14. The apparatus according to claim 13, wherein: said location identifier laser probe and temperature probe along at least a portion of the length of each of the spaced apart at equal distances.
  15. 15.根据权利要求13所述的装置,其中:所述位置标识沿着激光探针和温度探针中的每一个的至少一部分长度以0.5cm的距离相互间隔。 15. The apparatus according to claim 13, wherein: said location identifier laser probe and temperature probe along at least a portion of the length of each of the spaced apart a distance to 0.5cm.
  16. 16.根据权利要求13所述的装置,其中:激光探针和温度探针均具有一个远端。 16. The apparatus of claim 13, wherein: the laser probe and temperature probe each have a distal end.
  17. 17.根据权利要求16所述的装置,其中:激光探针的远端与温度探针的远端在轴向上相距1.0cm。 17. The apparatus according to claim 16, wherein: the distal end of the distal end of the laser probe and temperature probe in the axial direction away from 1.0cm.
  18. 18.根据权利要求13所述的装置,其中:温度探针包括5个温度探测器,其中每个探测器位于沿着温度探针的相应位置标识处。 18. The apparatus according to claim 13, wherein: the temperature probe comprises five temperature detectors, wherein each detector is located at a corresponding position along the temperature probe identification.
  19. 19.根据权利要求18所述的装置,其中:温度探测器之一位于与激光探针的远端相距1.0cm的位置处。 19. The apparatus of claim 18, wherein, wherein: one of temperature probes located at the distal end of the laser probe position 1.0cm apart of.
  20. 20.根据权利要求19所述的装置,其中:激光探针的远端在肿瘤块中居中定位。 20. The apparatus according to claim 19, wherein: the distal end of the laser probe centrally located in the tumor mass.
  21. 21.用于确定被破坏肿瘤块体积的一种方法,该方法包括如下步骤:提供具有一个温度传感器的一个温度探针和一个激光探针;将激光探针和温度探针插入以测量肿瘤块的温度和肿瘤块周围的组织块的温度;根据肿瘤块温度和组织块温度确定被破坏的肿瘤块的体积;将被破坏肿瘤块的体积的图形标识显示出来。 21. A method for determining the destruction of tumor mass volume, the method comprising the steps of: providing a temperature probe and a laser probe having a temperature sensor; laser probe and temperature probe is inserted to measure the tumor mass The temperature and the temperature of the tissue mass surrounding the tumor mass; according to tumor mass temperature and temperature determine the volume of tissue mass destruction of tumor mass; the graphics are destroyed tumor mass volume identifier is displayed.
  22. 22.根据权利要求21所述的方法,其中:被破坏肿瘤块体积的图形标识包括一个圆形标识。 22. The method according to claim 21, wherein: the volume of tumor mass destroyed graphical identification comprises a circular identification.
  23. 23.根据权利要求21所述的方法,其中:对被破坏肿瘤块的图形标识进行显示包括显示出一个球形标识。 23. The method of claim 21, wherein: the destruction of tumor mass identification graphical display includes displaying a spherical identification.
  24. 24.根据权利要求22所述的方法,其中:对被破坏肿瘤块体积的图形标识进行显示包括将破坏区的图像添加到肿瘤块的图像上。 24. The method according to claim 22, wherein: the volume of tumor mass destroyed graphical indication comprises adding an image display area destroyed tumor mass onto the image.
  25. 25.根据权利要求21所述的方法,其中:该方法包括对被破坏肿瘤块的体积进行即时可视性监控的步骤。 25. The method according to claim 21, wherein: the method comprising the steps of a volume of tumor mass destroyed instant visibility monitoring.
  26. 26.根据权利要求21所述的方法,其中:该方法包括在间隙式激光治疗过程中对被破坏肿瘤块体积的图形标识进行显示。 26. The method according to claim 21, wherein: the method comprises a gap during laser treatment is the destruction of tumor mass volume of graphical indication is displayed.
  27. 27.根据权利要求21所述的方法,其中:该方法包括利用血液循环测试来确认整个肿瘤块被有效破坏掉。 27. The method according to claim 21, wherein: the method comprises the use of a blood circulation test to confirm that the entire tumor mass is effectively destroyed.
  28. 28.根据权利要求27所述的方法,其中:该方法包括在肿瘤块被破坏之前及破坏之后进行血液循环测试。 28. The method according to claim 27, wherein: the method comprises, after and before the destruction of tumor mass destroyed blood circulation test.
  29. 29.根据权利要求21所述的方法,该方法包括:在对肿瘤块进行破坏过程中进行一次血液循环测试,并对血液循环测试进图示性显示以对被破坏的肿瘤块体积进行即时监控。 29. The method according to claim 21, the method comprising: performing a blood circulation test of the destruction process in the tumor mass, and blood circulation tests are shown in the diagram of the volume of tumor mass destroyed instantly monitor .
  30. 30.根据权利要求21所述的方法,该方法包括如下步骤,即对激光探针与温度探针的相对距离进行测量。 30. The method according to claim 21, the method comprising the steps, i.e., the relative distance between the laser probe and temperature probe was measured.
  31. 31.根据权利要求30所述的方法,其中:所述测量步骤包括通过利用位于每个激光探针和温度探针上的多个位置标识进行测量。 31. The method according to claim 30, wherein: said measuring step comprises the measurement by using a plurality of positions located at each of the laser probe and temperature identification probe.
  32. 32.根据权利要求21所述的方法,该方法包括将肿瘤块的中心温度保持在60℃-100℃范围内的一个步骤。 32. The method according to claim 21, which comprises a step of holding the center of the tumor mass temperature within the range of -100 ℃ of 60 ℃.
  33. 33.根据权利要求21所述的方法,该方法包括这样一个步骤:即对与被破坏的肿瘤块体积相应的激光能量进行计算。 33. The method according to claim 21, which comprises a step of: the volume of tumor mass destroyed with the respective laser energy is calculated.
Description  translated from Chinese
用于传送烧蚀性激光能及确定受破坏肿瘤体积的装置和方法 For delivering ablative laser energy and determination means and methods by destruction of tumor volume

在现场或原地经由皮肤对恶性乳腺肿瘤进行激光治疗的方式目前已得到了发展,这种情况部分是由于每年接受乳房X线摄影的妇女数量增多,从而在早期就可检测到乳腺癌。 On-site or in-situ way via skin malignant breast tumors laser treatment has been developed, this situation is partly due to an increase in the number of women each year breast X-ray photography, which can be detected at an early stage breast cancer. 如果乳腺癌及其他癌症或肿瘤能在早期被发现的话,则可利用烧蚀作用如激光能对肿瘤进行有效治疗。 If breast cancer and other cancers or tumors can be detected at an early, then you can use the role as laser ablation of tumors can be effectively treated.

恶性肿瘤如乳腺肿瘤、肝脏肿瘤、脑瘤及颈部肿瘤的图像导引激光治疗技术已发展了十多年了。 Malignant tumors such as breast cancer, liver cancer, brain tumors and neck cancer image guided laser treatment technology has been developed over a decade. 例如,授予Dowlatshahi的美国专利No.5,169,396(第396号专利)涉及对肿瘤块进行激光治疗的一种间隙式应用,该专利在此作为参考而被结合使用。 For example, granting Dowlatshahi U.S. Patent No.5,169,396 (No. 396 patent) relates to laser treatment of tumor blocks a gap-type applications, which is incorporated herein by reference and are used in combination. 总体上,第“396”号专利所披露的装置包括一个探针、一个激光器和一根光学纤维。 Overall, the device disclosed in the first "396" No patents include a probe, a laser and one optical fiber. 所述探针具有用于插入肿瘤块的一个细金属套管,激光器用于产生具有所选择波长和强度的激光,所述光学纤维用于接收激光光线且将该光线传输至肿瘤块中,此时将光学纤维插入所述套管,这样一种经选择且可接受的生理流体就在套管和光学纤维之间同轴流动。 The probe for insertion into the tumor mass having a thin metal sleeve, having a laser for generating a selected wavelength and intensity of the laser, the optical fiber for receiving the laser beam and the light transmitted to the tumor mass, then this When the optical fiber is inserted into the sleeve, so that a selected and physiologically acceptable fluid flow between the sleeve in coaxial and optical fiber. 此外,将一个热传感件贴靠着插入肿瘤块中以监控肿瘤的温度。 In addition, a thermal sensor element inserted into the tumor mass abuts to monitor tumor temperature. 这样,通过身体免疫系统将失去生命力的肿瘤逐渐清除掉且在六个月内由一个疤痕所取代。 Thus, by the body's immune system will gradually lose its vitality tumor removed and be replaced by a scar within six months.

但是,通常认为肿瘤的治疗、特别是乳腺肿瘤的特殊治疗是更加困难的,这是由于很难确定肿瘤的三维边界,从而就难于确定全部肿瘤何时被破坏掉。 Typically, however, that the treatment of tumors, especially breast cancer special treatment is more difficult, it is difficult to determine due to the three-dimensional tumor boundaries, so it is difficult to determine when the entire tumor is destroyed.

为解决这个问题,医疗工作者已利用了多种肿瘤块鉴定技术来确定肿瘤块的尺寸和外边界。 To solve this problem, the medical workers have utilized a variety of tumor blocks and identification techniques to determine the size of the outer boundary of the tumor mass. 与激光治疗结合使用的常用鉴定技术的例子为磁共振成像技术、X光线摄影技术和超声诊断技术。 Laser therapy combined with common techniques used to identify examples of magnetic resonance imaging, X - ray photography and ultrasound diagnostic techniques. 在利用一种鉴定技术时,通过使用立体定向技术或类似技术来确定坐标,该坐标就可鉴定肿瘤块的实际尺寸。 When using an identification techniques, through the use of stereotactic technique or the like to determine the coordinate that can identify the actual size of the tumor mass.

为解决这个问题,在进行激光治疗时,将标记置于“正常”组织的一个0.5-1.0cm的区域内以划分出肿瘤扩充的区域。 To solve this problem, during the laser treatment, the marker is placed within the area of "normal" tissue to be divided into a tumor 0.5-1.0cm expanded area. “正常”组织所在的环区等于这样一种组织的环区,即该组织包含有在通常的外科手术(如乳房肿瘤切除术)中所除去的肿瘤。 "Normal" tissue where the ring area equal to such an organized ring area, which includes the organization's tumor is usually surgery (such as lumpectomy) The removed. 通过经由一个针头而将金属标记插入,从而在3、6、9、12点钟的位置处标识出肿瘤周围的边界。 Via a needle which is inserted a metal tag, which identifies a boundary around the tumor in a position 3,6,9,12 o'clock. 利用已知的立体定向技术并使用商业上应用的立体定向标签来精确确定插入点。 Using known stereotactic technique and application of commercial use of stereotactic labels to accurately determine the insertion point.

这种标识元件是授予Dowlatshahi的美国专利No.5,853,366所披露的主题,该专利涉及用于间隙式治疗的一种标识元件。 Such identification element is a subject matter disclosed in U.S. Patent No.5,853,366 granted Dowlatshahi, which patent relates to an identification device for the gap-type treatment. 总体上来说,第“366”号专利披露了可被整体置于病人身体中的一种标识元件,利用一种具有导引路径的引导部件将该元件定位的病人身体中,从而标识出相应的肿瘤。 Generally speaking, the first "366" No. Patent discloses a patient's body may be placed integrally in one identification element, using a guide member having a guide path of the element is positioned in the patient's body, thereby identifying the corresponding tumors. 该标识元件是利用辐射透不过的材料制成的,该材料包括可通过常用的X光线摄影技术、超声诊断技术或电磁技术检测到的任何材料。 The identity element is the use of a radiopaque material, the material includes any material but is detected by conventional X-ray photography, ultrasound diagnostic technology or electromagnetic technology.

医疗工作者还使用了除激光治疗之外的非外科技术来治疗乳腺肿瘤。 Medical workers also used in addition to the non-surgical laser treatment technology to treat breast cancer. 例如,他们尝试利用了无线电射频方式、微波方式及相关的低温治疗方式。 For example, they try to use the radio frequency mode, a microwave method and associated hypothermia treatment.

本发明已认识到上述问题,即提供一种非切除式的癌症治疗方式、特别是乳腺癌的治疗方式,这种方式可可靠地确定整个肿瘤是何时被有效破坏的。 The present invention has recognized the above problem, i.e. to provide a non-excisional treatment of cancer, especially breast cancer treatment, this approach can reliably determine when the entire tumor is effectively destroyed. 因此,目前存在进行非切除式癌症治疗的需要,本发明即可解决这种问题以及由难于确定肿瘤是否被完整消灭而引发的问题。 Therefore, there is now need for a non-excisional treatment of cancer, the present invention can solve this problem and is difficult to determine whether the tumor is by the complete elimination of problems caused.

发明内容 DISCLOSURE

本发明通过提供一种装置和方法来解决上述问题,该装置和方法用于确定病人身体内的组织块(例如乳腺组织)中被破坏的肿瘤块(如乳腺癌)的体积,这样,被破坏的肿瘤块的图形标识就可适当地形成于实际肿瘤块的图像上,因此就可即时可视性地监控对肿瘤块的破坏程度。 The present invention provides an apparatus and method for solving the above problems, the means and methods for determining the volume of the patient's body within the organization block (for example breast tissue) was destroyed tumor mass (such as breast cancer), so that was destroyed graphic tumor mass identification can be properly formed on the image of the actual tumor mass, so you can monitor real-time visibility into the extent of damage to the tumor mass. 接合乳腺组织和乳腺癌或肿瘤对本发明进行描述,但应认识到本发明可应用于其他肿瘤或癌症的治疗。 Engaging breast tissue and breast cancer or tumors present invention will be described, it should be appreciated that the present invention may be used to treat other tumors or cancers. 本发明还可通过将病人置于一种商用的立体定向台上来实现。 The present invention also by placing the patient stereotactic table to achieve a commercial. 如果将组织块如乳腺固定且将目标锁定,则可利用超声和磁共振成像(MRI)技术来实现本发明。 If the block such as breast tissue is fixed and will be targeted, you can use ultrasound and magnetic resonance imaging (MRI) technology to achieve the present invention.

本发明一个实施例中的装置优选包括一个激光枪。 A preferred embodiment of the apparatus embodiment of the present invention comprises a laser gun. 激光枪具有一个其上带有温度传感器的激光探针和一个其上带有多个温度探测器的温度探针。 Laser gun has a laser probe with its temperature sensor and a temperature probe thereon a plurality of temperature detectors. 激光枪将激光探针插入肿瘤块中以提供足够量的激光辐射且在激光的施加点处测量肿瘤的温度。 The laser probe is inserted into the laser gun tumor mass to provide a sufficient amount of laser radiation and measuring the tumor temperature at the application point of the laser. 然后,激光枪将温度探针插入人体中优选与肿瘤块非常靠近的部位。 Then, the laser gun and the temperature probe is inserted into the body preferably very close to the site of the tumor mass. 在间隙式激光治疗过程中,温度探针在肿瘤块附近的多个位置处测量身体或组织的温度。 In the space laser treatment, a temperature probe to measure the temperature of the body or tissue at a location more than one tumor block nearby. 激光探针和温度探针最好包括有位置标记以使操作者精确地定位并确定探针之间的相互位置。 The laser probe and temperature probe preferably include position marks to enable the operator to accurately locate and determine the mutual position between the probes.

该装置优选包括一个计算机控制系统,该计算机控制系统与激光枪及其部件即激光探针、传感器、温度探针和探测器电动连接。 The apparatus preferably includes a computer control system, the computer control system and laser guns and their components namely laser probe, sensor, temperature probe and probe electrical connections. 计算机控制系统利用操作数据如由控制系统从激光探针和温度探针处接收到的温度数据及温度传感器之间的距离来确定被破坏的肿瘤块的体积。 Computer control system using the operation data received by the control system, such as the distance from the laser probe and temperature probe at the temperature data and temperature sensors to determine the volume of tumor mass destroyed. 在间隙式激光治疗的过程中,计算机控制系统可根据肿瘤块温度及肿瘤块周围的身体或组织块的温度而在任何时间计算出被破坏的肿瘤块的体积。 In the space of laser treatment process, the computer control system at any time to calculate the volume of tumor mass destroyed tumor mass temperature and the temperature surrounding the tumor mass, body or organization blocks.

在计算机控制系统计算被破坏的肿瘤块体积的同时,计算机控制系统显示出肿瘤块被破坏的量的连续图形标识,这些图形标识可即时附加到实际肿瘤块的图像上。 In the computer control system calculates the volume of tumor mass is destroyed while the computer control system displays the amount of destruction of tumor mass continuous graphical indication, these graphics can instantly identify the actual image attached to the tumor mass. 该图形显示使医生在间隙式激光治疗的过程中能够可视觉性地即时监控被破坏的肿瘤块的量,这样,使用者就可确定对肿瘤块的破坏是在何时有效完成的。 The graphic display allows doctors in the process of gap-type laser therapy can be to visually monitor the amount of immediate destruction of tumor mass, so that the user can determine the destruction of the tumor mass is effective when done.

因此,本发明的一个优势在于提供了一种用于计算被破坏的肿瘤块体积的装置和方法,从而显示出被破坏的肿瘤块的图形标识。 Thus, one advantage of the present invention to provide a method for calculating the volume of tumor mass destroyed apparatus and methods, thus showing the pattern is destroyed tumor mass identification.

本发明的另一个优势在于:在激光治疗过程中可对肿瘤块的破坏进行即时的可视性监控。 Another advantage of the present invention is that: the laser treatment process to destroy the tumor can block instant visibility monitoring.

本发明的另一个优势在于提供了一种用于确定肿瘤块在何时被有效地完全破坏掉的装置和方法。 Another advantage of the present invention is to provide an apparatus and method for tumor blocks completely destroyed when it was effectively out for OK.

本发明的另一个优势在于提供了一种装置和方法,在间隙式激光治疗的过程中,该装置和方法用于确定乳腺肿瘤块是在何时被有效完整破坏的。 Another advantage of the present invention is to provide an apparatus and method, in the process of laser treatment gap, the apparatus and method for determining when a breast tumor mass is effectively complete destruction.

通过下面的描述内容,并接合附图可明确本发明的其他目的、特征和优点,在附图中相同的参考符号指示同样的备件、部件、过程和步骤。 The contents of the following description and drawings can be clearly engaging other objects, features and advantages of the present invention, the same reference numerals indicate like parts, components, processes and procedures in the drawings.

通过下文中详细描述的发明内容和附图可明确本发明的其他特征和优点。 Disclosure of the detailed description and drawings can be clearly below the other features and advantages of the present invention.

附图说明 Brief Description

图1A所示为确定被破坏的肿瘤块的体积所用的本发明装置的透视图;图1B所示为本发明装置的一个透视图,图中显示了激光枪;图2A所示为激光探针和温度探针在插入包含有肿瘤块的组织块或身体之前的一个示意图;图2B所示为被插入包含有肿瘤块的组织块中的激光探针和温度探针的一个示意图;图3所示为激光探针和温度探针的示意图,图中显示了被破坏的肿瘤块的体积与激光探针的温度传感器及温度探针的温度探测器之间的相互关系;图4A-4C显示了在激光治疗的初始阶段、随后阶段和最终阶段的肿瘤块破坏区以对肿瘤块的消除情况进行可视性的即时监控;图4D-4H显示了在激光治疗的初始阶段、随后阶段和最终阶段的肿瘤块破坏区的另一个图形标识以对肿瘤块的消除情况进行可视性的即时监控;图4I和4J显示了在肿瘤块的不同破坏阶段而在Tc、T1、T2、T3、T4、T5位置处的另一个柱形温度标识图;图5A、5B和5C显示了在治疗之前和治疗之后由彩色多普勒超声装置检测到的、在肿瘤块周围的肿瘤块和组织块中的血液流动情况。 Fig perspective view of determining the volume of destroyed tumor mass used according to the present invention, the apparatus shown in 1A; 1B of the present invention shown in a perspective view in FIG apparatus, showing a laser gun; Fig. 2A shows the laser probe and inserting a temperature probe contains a schematic block tumor tissue or body before the block; FIG. 2B is a schematic view of the laser probe and temperature probe is inserted into the tissue mass containing the tumor mass; Fig. 3 a schematic diagram of the laser probe and temperature probe, showing the relationship between the temperature sensor and temperature probe was destroyed tumor mass volume of the laser probe and temperature probe between; Figures 4A-4C show In the initial stage of laser treatment, followed by tumor mass destruction zone stage and the final stage in order to eliminate cases of tumor mass were the visibility of real-time monitoring; Fig. 4D-4H show the laser treatment in the initial stages, later stage and final stage The tumor mass destruction zone of another graphic logo to the elimination of tumor mass were the case the visibility of real-time monitoring; Fig. 4I and 4J shows the different stages of tumor mass destruction while at Tc, T1, T2, T3, T4, Another cylinder temperature at the location identified in Figure T5; Fig. 5A, 5B and 5C show before treatment and after treatment detected by color Doppler ultrasound device to, in tumor mass surrounding the tumor mass and tissue blocks the blood flow. 图5A显示了在没有对比剂的辅助下而在治疗之前的血流情况。 Figure 5A shows a contrast agent in the absence of the aid in the blood flow before treatment. 图5B显示了在有对比剂的辅助下而在治疗之前的血流情况。 Figure 5B shows the auxiliary contrast agent and before the treatment at the blood flow. 图5C显示了在治疗之后的血流损失情况;图6所示为一个照片,该照片中显示了通过本发明的激光治疗而破坏的实际肿瘤块。 Figure 5C shows the situation after treatment blood loss; shows a photograph, the photograph shown in Figure 6 the actual tumor mass through the laser treatment and the destruction of the present invention.

具体实施方式 DETAILED DESCRIPTION

现在参考附图,特别参考附图1A、1B、2A和2B,图中总体上显示了用于确定被破坏的肿瘤块体积的装置和方法。 Referring now to the drawings, particularly with reference to the accompanying drawings 1A, 1B, 2A and 2B, a display apparatus and a method for determining the volume of tumor mass destroyed generally to FIG. 本发明通过依据将在下文中描述的肿瘤块温度和肿瘤块周围的组织块温度的相对温度来确定被破坏肿瘤块的体积而对被破坏肿瘤块的体积进行图形显示或标识。 Temperature and relative humidity of tumor mass surrounding the tumor mass of tissue block temperature according to the present invention will be described by the following in determining the volume of tumor mass is destroyed while the volume of tumor mass destroyed graphical display or logo. 该显示图最好提供给医生或其他可对肿瘤块的破坏程度进行即时可视性监控的操作者以确定整个肿瘤块是在何时被有效完整破坏掉的。 This is shown in Figure preferably provided to a physician or other damage to the extent of the tumor mass for instant visibility monitoring operator to determine when the entire tumor mass is effectively destroyed the complete.

本发明利用激光探针的一个温度传感器和具有多个温度传感器或探测器的一个独立的温度探针来监控肿瘤块内及肿瘤块附近区域中的温度。 The present invention utilizes a laser probe and a separate temperature sensor a temperature probe having a plurality of temperature sensors or detectors to monitor the area near the tumor mass and the temperature of the tumor mass. 该温度传感器和温度探针提供用以确定被破坏肿瘤块的温度数据,从而提供被破坏肿瘤块的即时图形显示。 The temperature sensor and temperature probe is provided for determining tumor mass destruction temperature data, providing immediate destruction of the tumor mass graphical display.

为计算被破坏的肿瘤块体积,则须将温度探针相对于温度传感器正确定位,二者之间的相对距离须精确确定。 To calculate the volume of tumor mass is destroyed, it shall be a temperature probe temperature sensor is properly positioned with respect to the relative distance between the two shall be precisely determined. 本发明利用布置在温度探针和激光探针上的多个位置标识以决定和确定温度检测器和激光探针之间的相对定位,该内容将在下文中进行描述。 The present invention utilizes a plurality of positions arranged identified on the temperature probe and laser probe to determine the temperature and determine the relative positioning between the detector and the laser probe, which content will be described below.

在一个实施例中,本发明优选包括一个激光枪10,该激光枪10包括一个在间隙式激光治疗过程中应用的探针保持件12。 In one embodiment, the present invention preferably includes a laser gun 10, the laser gun 10 includes a probe laser application in the gap holding member 12 during treatment. 该探针保持件12用于接收一个激光探针14和一个温度探针16。 The probe holder 12 for receiving a laser probe 14 and a temperature probe 16. 激光探针14和温度探针16可移动性地插入探针保持件中且从其中延伸出。 The laser probe 14 and temperature probe 16 may be inserted into the mobility probe holding member and which extends out from. 激光探针14和温度探针16通过激光枪而保持在相对的固定位置中。 The laser probe 14 and temperature probe 16 by a laser gun is held in a relatively fixed position. 根据本发明而可对激光探针14和温度探针16的定位进行人工控制或计算机控制。 The laser probes can locate 14 and temperature probe 16 is manually controlled or computer-controlled in accordance with the present invention.

激光探针14包括一个温度传感器15。 The laser probe 14 includes a temperature sensor 15. 激光探针14用于接收与激光源20相连的一根光学纤维18,该激光源20与一个计算机控制系统22相连。 The laser probe 14 for receiving the laser source 20 is connected to one optical fiber 18, the laser light source 20 is connected to a computer control system 22. 控制系统22优选通过一个温度控制装置24与温度探针16及激光探针14的温度传感器15相连,从而简化与计算机控制系统22的电动连接。 Control system 22 is preferably connected to the temperature sensor 24 and a temperature probe 16 and laser probe 14 of 15 by a temperature control device, thereby simplifying the electrical and computer control system 22 is connected. 但是,激光探针14和温度探针16可具有均与一个中央计算机控制系统(图中未显示)相连的独立控制系统。 However, the laser probe 14 and temperature probe 16 may have associated with a central computer control system (not shown) is connected to an independent control system.

更具体地说,激光探针14包括用于插入肿瘤块的一个较细的金属套管和用于接收激光或辐射且将其传输至肿瘤块的一根光学纤维,所述光学纤维被插入套管中,这样,就如在第“396”号专利中所描述的那样,一种已选择的生理流体或麻醉剂可在套管和光学纤维之间流动,如上所述,第“396”号专利在本申请中作为参考而被接合使用。 More specifically, the laser probe 14 for insertion into a tumor mass comprising a thin metal sleeve for receiving a laser or radiation and to transfer it to a tumor mass of one optical fiber, said optical fiber is inserted into the sleeve tube, so that, as in the first "396" was described in the patent as a selected physiological fluids or anesthetic agent can flow between the sleeve and the optical fiber, as described above, the first "396" No Patents In the present application by reference used is bonded. 在一个优选的实施例中,较细的金属套管的长度约为18cm且由规格为16-18但优选规格为16的不锈钢制成。 In a preferred embodiment, the thin metal sleeve 18cm and a length of about 16-18, but preferably by the specifications for size 16 made of stainless steel. 此外,所述光学或激光纤维为直径在400nm-600nm范围内的石英纤维且具有一个球形顶端。 In addition, the optical or laser fiber having a diameter in the range of 400nm-600nm and a quartz fiber having a spherical tip. 该光学纤维是商业上应用的光学纤维,如来自Texas州的Woodland的SURGIMED制造的光学纤维。 The optical fiber is an optical fiber applications commercially, such as the optical fiber from the Texas State SURGIMED Woodland manufactured.

可运用任何适当的流体泵26来输送液体,这样,肿瘤在激光治疗过程中的中心温度就不会超过100℃或低于60℃。 You may use any suitable fluid pump 26 to transport liquid, so that the laser treatment of cancer in the course of the core temperature does not exceed 100 ℃ or below 60 ℃. 在一个实施例中,液体可以在0.5ml/min-2.0ml/min范围内的一个速度传输。 In one embodiment, the liquid can be transmitted in a rate 0.5ml / min-2.0ml / min range.

激光源20产生有效量的激光辐射并将该激光辐射施加到激光探针14中。 Laser source 20 generates an effective amount of laser radiation and the laser radiation is applied to the laser probe 14. 激光源20最好是二极管激光器。 Laser source 20 is preferably a diode laser. 特别地,激光源20是一种商业上常用的半导体805nm的二极管激光器,例如由英格兰剑桥的Diomed生产的激光器。 In particular, the laser source 20 is a commercially popular semiconductor 805nm diode laser, such as laser from Cambridge, England Diomed production. 但是,本发明并不仅限于利用二极管激光器,而可使用多种不同的适当激光源。 However, the present invention is not limited to the use of diode lasers, but may use a variety of different suitable laser sources.

激光探针14还包括如前所述的一个温度传感器15。 The laser probe 14 also includes a temperature sensor 15 as previously described. 在肿瘤块被破坏时,温度传感器15可有效地测量肿瘤块中心的温度。 When the tumor mass is destroyed, the temperature sensor 15 is effective to measure the temperature of the center of the tumor mass. 温度传感器15最好通过焊接或其他连接装置直接附加到激光探针14上,从而在激光探针14的远端28处测量肿瘤块的温度,激光探针14的远端28优选位于肿瘤块的中心区域处。 Temperature sensor 15 is preferably attached directly to a by welding or other attachment means 14 of the laser probe, laser probe temperature so that the distal end 14 of the 28 tumors were measured block laser probe 28 is preferably located at the distal end 14 of the tumor mass central region.

温度探针16的远端30插入身体部位的组织块内的身体之中,该部位与肿瘤块相邻(例如,最好距肿瘤块10cm远)且包围肿瘤块。 Temperature probe distal end 30 of body 16 inserted into the body parts of the organization within the block among blocks adjacent to the site of the tumor (for example, the best piece 10cm away from the tumor) and tumor mass surrounded. 温度探针16具有多个温度探测器32或传感器,这些探测器或传感器沿着温度探针以不同的距离或间隔(例如,优选为0.5cm)布置。 Temperature probe 16 having a plurality of temperature detectors 32 or sensors, these temperature detectors or sensors along the probe at different distances or intervals (e.g., preferably 0.5cm) arranged. 在一个优选实施例中,温度探针16是由规格在16-20内且优选规格为16的不锈钢制作的。 In a preferred embodiment, the temperature probe 16 is made in the size and preferably 16-20 specifications 16 made of stainless steel. 就如在图3中进一步显示的那样,温度探针16的温度探测器32布置在T1、T2、T3、T4、T5处。 As further shown in Figure 3 above, a temperature probe temperature probe 16 of 32 arranged in T1, T2, T3, T4, T5 place. 依据这种结构,则可在距肿瘤块表面的不同距离处得到肿瘤块温度测量值。 According to this structure, the tumor mass temperature can be obtained from the measured values of the tumor mass surface at different distances. 该温度数据与温度传感器的相应的距离相结合来计算被破坏的肿瘤块的体积,因此,所述温度数据被用来确定整个肿瘤块是在何时被有效破坏的,该内容将在下文中描述。 Corresponding to the temperature data from the temperature sensor to calculate the combined volume of tumor mass destroyed, and therefore, the temperature data is used to determine when the entire tumor mass is effectively destroyed, the contents of which will be described hereinafter .

如上所述,温度探针16与激光探针14的相对位置必须确定以精确计算被破坏的肿瘤块的体积。 As described above, a temperature probe 16 and laser probe 14 must be determined relative position to accurately calculate the volume of tumor mass destroyed. 如图1A所示,温度探针16和激光探针14包括多个位置标识34以确定温度探针16和激光探针14的相对位置。 1A, the temperature probe 16 and laser probe 14 includes a plurality of positions relative location identifier 34 to determine the temperature probe 16 and laser probe 14. 位置标识34最好沿着温度探针16的部分长度和激光探针14的部分长度以优选0.5cm的距离均匀间隔布置。 34 best position to identify the temperature probe 16 along part of the length and the length of the laser probe portion 14 by a distance of 0.5cm preferably evenly spaced. 但是,本发明并不仅限于该距离而可包括处于不同位置处的相间隔位置标识。 However, the present invention is not limited to this distance may include spaced locations identified in phase at different locations. 操纵者可利用这些位置标识来正确定位激光探针及与激光探针相应的温度探针。 The operator can use these positions to identify the correct positioning of the laser probe and laser probe corresponding temperature probes.

本发明优选包括计算机控制系统22,该控制系统22与激光枪10及其部件即温度探针和具有温度传感器15的激光探针14电动连接。 The present invention preferably includes a computer control system 22, the control system 22 and the laser gun 10 and its components namely, temperature probe, and a temperature sensor laser probe 15 of 14 electric connection. 在肿瘤块被加热和破坏时,计算机控制系统22接收来自激光探针14和温度探针16的数据。 When the tumor mass is heated and destroyed, the computer control system 22 receives the probe 14 and temperature probe data 16 from the laser. 该数据被用于计算在任何给定时间的被破坏的肿瘤块的体积。 This data is used to destroy the tumor volume was calculated block at any given time. 所述计算是以来自温度探针16和温度传感器15的温度数据为依据的。 The calculation is based from the temperature probe 16 and temperature sensor data 15 is based. 计算机控制系统22利用被破坏的肿瘤体积计算值而在与计算机控制系统22相连的一个显示器36上示意性地显示出被破坏的肿瘤块体积(即肿瘤块破坏区)。 Computer control system 22 uses the calculated value was destroyed tumor volume while on the computer control system 22 is connected to a display 36 schematically shows the destruction of the tumor mass volume (ie, a tumor mass destruction zone).

在一个实施例中,激光枪10将激光探针14和温度探针16推入乳腺组织38中以破坏躺在检查台42上的病人41的乳腺组织38内的肿瘤块40。 In one embodiment, the laser gun 10 laser probe 14 and temperature probe 16 is pushed into the breast tissue to destroy 38 to check a patient 42 lying on the stage breast tissue 41 40 38 within the tumor mass. 激光枪10布置在一个立体定向平台或平桌44上。 Laser gun 10 is arranged on a stereotactic platform or flat desk 44. 立体定向平台或平桌44以通常的方式应用而在将温度探针16和激光探针14插入乳腺组织38之前辨识肿瘤块40在乳腺组织38中的实际位置。 Stereotactic platform or flat desk 44 applications in the usual way in the temperature probe 16 and laser probe 14 is inserted into the breast tissue before the actual position 38 to identify 40 of the 38 tumor mass in the breast tissue. 在一个优选的实施例中,立体定向平台或平桌44是由Danbury,Connecticut的LORAD/Trex MedicalStereoguide DSM制造的商用平台。 In a preferred embodiment, the stereotactic platform or flat desk 44 by the Danbury, Connecticut's LORAD / Trex MedicalStereoguide DSM commercial manufacturing platform. 但是,可利用常用的放射照像辨识技术、超声诊断辨识技术、热成像辨识技术、磁成像辨识技术或其他类似辨识技术来实现上述的辨识。 However, we can identify by conventional radiographic techniques, diagnostic ultrasound recognition technology, thermal imaging recognition technology, magnetic imaging recognition technology or other similar identification techniques to achieve the above identification.

在辨识出肿瘤块40的位置之后,优选将多个标识元件46插入与乳腺肿瘤40相靠近的乳腺组织38中。 After the identification of the location of the tumor block 40 is preferably multiple identities element 46 is inserted breast tissue and breast tumor 40 with close to 38. 标识元件46用于标识出被治疗的肿瘤块40,并随后对治疗区进行辨识和观察,该内容在前面所述且在本申请中作为参考使用的第“366”号专利中做了进一步的描述。 Identification element 46 is used to identify the tumor mass to be treated 40, and then to identify and observe the treatment zone, the content and in the present application as the reference used in the front of the "366" number of patents has been further description.

通过明确肿瘤块的真正位置,可利用激光枪10在与乳腺组织38中的肿瘤块40相关的一个最优位置处将激光探针14和温度探针16推入乳腺组织38中。 By explicitly tumor mass real location, you can use the laser gun 10 in an optimal position with the breast tissue in 38 of 40 tumor mass associated with the laser probe 14 and temperature probe 16 is pushed into the breast tissue 38. 本发明利用了一个探针引导件48以易于将温度探针16和激光探针14插入乳腺组织38中。 The present invention utilizes a probe guide 48 for ease of the temperature probe 16 and laser probe 14 is inserted into the breast tissue 38. 在显示器36上就可可视性地监控与肿瘤块40及肿瘤块周围的组织块的位置相应的激光探针14、温度探针16和标识元件46的位置。 Visibility on the display 36 can monitor the position of the tumor tissue mass surrounding the tumor mass block 40 and the corresponding laser probe 14, 16, and identifies the location of a temperature probe element 46.

如上所述,本发明利用一个激光枪10以将激光探针14和温度探针16推入肿瘤块和肿瘤块周围的组织块中。 As described above, the present invention utilizes a laser gun 10 to the laser probe 14 and temperature probe 16 is pushed into the tumor mass and tissue mass surrounding the tumor mass. 激光枪10可由任何适当的材料制成且可被构造成不同的结构。 Laser gun 10 may be of any suitable material and may be configured to a different configuration. 图1B中显示了这种结构的一个例子。 Figure 1B shows an example of such a structure.

激光枪10被定位在立体定向平台44的一个导引机构52上,该立体定向平台44可在插入激光探针和温度探针之前将激光枪10定位。 Laser gun 10 is positioned on a platform with stereotactic guiding mechanism 52 44, the stereotactic platform 44 prior to insertion of the laser probe and temperature probe laser gun 10 is positioned. 激光枪10包括用于容纳激光探针和温度探针及探针保持件12的一个壳体54,每个激光探针和温度探针所用的探针保持件12可从壳体中延伸出来。 Receiving the laser gun 10 includes a laser probe and temperature probe and probe holding member 12 of a housing 54, each of the laser probe and temperature probe used for holding the probe member 12 may extend from the housing. 激光枪10还包括附加在壳体上的一个对准部件56而在插入之前使激光枪对准。 Laser gun 10 also includes an additional alignment of the housing member 56 prior to insertion of the laser gun. 激光枪10还包括附加在壳体上的一个插入部件58以自动插入激光探针和温度探针。 Laser gun 10 further comprises automatically inserting the laser probe and temperature probe attached to an insertion member 58 of the housing. 激光枪10与控制系统59相连,该控制系统59包括一个计算机处理单元60。 Laser gun 10 is connected to the control system 59, the control system 59 includes a computer processing unit 60. 在激光治疗过程中,控制系统59运行以控制和监控温度探针和激光探针,例如控制激光源和流体泵及监控所述温度。 In the laser treatment process, the control system 59 to control and monitor the operation of a temperature probe and laser probe, such as controlling the laser source and fluid pump and monitor the temperature.

如图2B所示,优选首先将激光探针14插入肿瘤块的中心。 2B, the laser probe 14 is preferably first inserted into the center of the tumor mass. 一旦优选性地将激光探针14插入肿瘤块40中,就如在图2A和2B中进一步显示的那样,优选将温度探针16插入且与激光探针14平行定位(例如,最好距激光探针约为1cm)。 Once a preference to the laser probe 14 is inserted into the tumor mass 40, on the way as in FIG. 2A and 2B further shown, it is preferable to insert a temperature probe 16 and laser probe 14 positioned in parallel (e.g., preferably from a laser Probe about 1cm). 在治疗过程中,温度探针16和激光探针14的最优位置对于监控从激光探针的顶端产生的热量的中心区是必需的。 During treatment, a temperature probe 16 and laser probe 14 of the best position to monitor the heat generated from the tip of the laser probe of the central area is required. 如下文所述,对激光探针的中心区产热图谱进行监控是必需的,从而对治疗过程中被破坏的肿瘤块体积进行有效检测。 As described below, the central region of the laser probe to monitor the heat pattern is required, thus the volume of tumor mass destroyed during treatment effectively detected.

由于相对于肿瘤块40正确且精确布置激光探针14及温度探针16非常重要,因此,本发明优选将立体定向技术与标识元件相结合以对上述部件的布置进行监控。 Since the block 40 relative to the tumor correct and precise placement of the laser probe 14 and temperature probe 16 is very important, therefore, the present invention preferably will stereotactic technique combined with the identification element to the arrangement of the above components to be monitored. 本发明还利用布置在每个温度探针16和激光探针14上的多个位置标识34来监控激光探针14相对于温度探针16的轴向定位。 The present invention is also the use of a plurality of positions arranged on each of the temperature probe 16 and laser probe 14 for monitoring the identity of 34 with respect to the laser probe 14 temperature probe 16 is positioned axially. 如上所述,位置标识34沿着温度探针16和激光探针14中的每一个以公知的距离优选0.5cm相互间隔。 As described above, the position of the probe identified 34 of 14 each a known distance spaced 0.5cm preferably along a temperature probe 16 and laser. 因此,位置标识34就被用于可视性地监控激光探针14和温度探针16的相对位置,这样,除利用计算机自动调整外,还可利用人工来调整激光探针14和温度探针16的相对位置。 Thus, 34 was used to identify the position of the visibility of the laser probe 14 to monitor the temperature and the relative position of the probe 16, so that, in addition to the use of computer automated adjustments can also be used to adjust the artificial laser probe 14 and temperature probe 16 in the relative position.

如图3所示,温度探针16优选包括一个温度探测器T3,该温度探测器T3与肿瘤块40的外表面相接触以测量该位置处的温度。 As shown, a temperature probe 16 preferably includes a temperature detector 3 T3, T3 and the tumor mass temperature detector 40 to measure the temperature of the outer surface of the contact at that location. 其他温度探测器即T1、T2、T4和T5沿着温度探针与T3以一定的距离(如上所述)间隔布置。 I.e. other temperature detectors T1, T2, T4 and T5 and T3 along the temperature probe at a certain distance (as described above) spaced. 每个温度探测器与温度探针14的温度传感器Tc(即,测量肿瘤块中心的温度)相距不同的径向距离即r1、r2、r3、r4、r5。 Each temperature probe and a temperature probe temperature sensor Tc 14 (i.e., the center of the tumor mass temperature measuring) distance i.e. different radial distances r1, r2, r3, r4, r5. Tc和T3之间的径向距离(即r3)是已知的,即Tc和T3之间的轴向距离优选为1.0cm。 The radial distance (i.e., r3) Tc and T3 are known between, i.e., preferably the axial distance between Tc and T3 is 1.0cm. 通过明确T3和其他温度探测器(即T1、T2、T4和T5)之间的距离以及T3和Tc之间的径向距离,利用勾股定理则可分别确定Tc与T1、T2、T4、T5之间的径向距离,即对于一个直角三角形来说,其斜边长度H与形成直角的侧边A、B之间存在如下关系,即H2=A2+B2。 By explicitly T3 and other temperature probe distance (ie T1, T2, T4 and T5) and the radial distance between T3 and Tc between using the Pythagorean theorem can be determined separately Tc and T1, T2, T4, T5 the radial distance between, i.e., for a right-angled triangle, its hypotenuse length H and is formed at right angles to the side A, the following relationship exists between the B, i.e., H2 = A2 + B2.

例如,(r1)2=(T1-T3)2+(r3)2=(1.0cm)2+(1.0cm)2=2.0cm2,其中T1-T3=1.0cm且r3=1.0cm,因此,r1=r5=(2.0cm2)1/2=1.4cm。 For example, (r1) 2 = (T1-T3) 2+ (r3) 2 = (1.0cm) 2+ (1.0cm) 2 = 2.0cm2, wherein T1-T3 = 1.0cm and r3 = 1.0cm, therefore, r1 = r5 = (2.0cm2) 1/2 = 1.4cm. 基于同样的计算,r4=r2=1.10cm,而T1-T2=0.5cm且R3=1.0cm。 For the same calculation, r4 = r2 = 1.10cm, and T1-T2 = 0.5cm and R3 = 1.0cm. 因此,肿瘤周围的组织温度相对于激光纤维顶端温度Tc的温度可通过温度探测器如T1、T2、T3、T4、T5来监控,所述监控是通过在距激光纤维顶端不同的已知或相应的径向距离来进行,如上述的r1=1.4cm,r2=1.10cm,r3=1.0cm,r4=1.10cm,r5=1.4cm。 Therefore, the tissue temperature surrounding the tumor relative to the laser fiber tip temperature Tc temperature by a temperature probe, such as T1, T2, T3, T4, T5 monitored, said monitoring is carried out by the laser fiber tip from respective different known or The radial distance to carry out, as described above r1 = 1.4cm, r2 = 1.10cm, r3 = 1.0cm, r4 = 1.10cm, r5 = 1.4cm.

通过确定所述径向距离,则可优选基于球体体积V的已知计算公式即V=4/3∏r3来计算每个温度探测器处的体积值,其中,r为距球体中心的径向距离,而∏为通用的常值22/7即任一圆的周长与其直径的比值。 By determining the radial distances, can be preferably based on the known formula V, i.e., the volume of a sphere V = 4 / 3Πr3 volume value calculated at each temperature detector, wherein, r is the radial distance of the center of the sphere distance, and Π is universal constant 22/7 in any ratio that is the circumference of a circle to its diameter. 当任一温度探测器处的温度达到可对肿瘤块进行破坏的温度值时,在每个温度探测器处的体积计算值与球形区域中被破坏的肿瘤块的体积有效对应,该球形区域具有与温度探测器相应的径向距离,即为r1、r2、r3、r4和r5。 When the temperature at any temperature probes can reach the tumor mass destruction temperature, the volume of the spherical region and the calculated value at each temperature probe volume of tumor mass destroyed effectively corresponds to the spherical region having a and temperature probes corresponding to the radial distance, i.e. r1, r2, r3, r4 and r5.

例如,在开始施加激光辐射时,则在Tc的区域处及在Tc区域的附近对肿瘤块40造成破坏。 For example, laser radiation is applied at the beginning, at the area in the vicinity of Tc and Tc regions in damage to the tumor mass 40. 随着时间的经过,与由T3所测量的温度的增加相对应,被破坏的肿瘤块的体积也增大。 With the elapse of time, increased by the measured temperature T3 corresponds to the volume of tumor mass destroyed increases. 因此,被破坏的肿瘤块的体积小于与所具有的径向距离为r3的球形区域相应的体积。 Thus, the volume of destroyed tumor mass is smaller than the radial distance corresponding with the volume of the spherical region r3.

当T3达到或增大至某一温度优选为60℃时,该温度可破坏肿瘤块,即为肿瘤块破坏温度,被破坏的肿瘤块体积与所具有的径向距离为r3的球形区域的体积有效对应。 When T3 reaches or increases to a certain temperature is preferably 60 ℃, the temperature may destroy the tumor mass, namely the tumor mass destruction temperature, the volume of the tumor mass is destroyed and the radial distance of the volume has a spherical region of r3 effective countermeasures. 被破坏肿瘤块的球形形状在侵蚀性乳腺肿瘤上得到确证,带有乳腺癌的36个病人的肿瘤经激光治疗而被顺次除去且由病理学者将其解剖并进行报告。 Destroyed tumor mass spherical shape corroborated on aggressive breast tumors, 36 patients with breast cancer after laser treatment and are sequentially removed and dissected by the pathologist and reported.

为确保整个肿瘤块被有效破坏掉,激光治疗连续进行直至由另外的或外部温度探测器即T1、T2、T4和T5测量的温度达到或增大至肿瘤块破坏温度优选为60℃。 To ensure that the entire tumor mass is effectively destroyed, laser therapy continued until that is T1, temperature T2, T4 and T5 measured reaches or increases to the tumor mass destruction temperature is 60 ℃ preferably by the additional or external temperature probe. 在发生这种情况时,球形区域的体积中的肿瘤块被有效破坏掉,该球形区域小于与外部温度探测器相关的径向距离为r1、r2、r4、r5的球形区域。 In this occurs, the volume of the spherical region of the tumor mass is effectively destroyed, the spherical area is smaller than the radial distance associated with the external temperature detector is r1, r2, spherical region r4, r5 of. 在最外部温度探测器如T1和T5所测量的温度增大至肿瘤块破坏温度优选为60℃时,激光治疗结束。 When the external temperature detector such as T1 and T5 measured temperature increases to the tumor mass destruction temperature is preferably 60 ℃, the end of the laser treatment.

应认识到:对于破坏肿瘤块和肿瘤块周围的组织块所需的激光能的能量也是可确定的。 It should be recognized: the destruction of the tumor mass and tissue mass surrounding the tumor mass required laser energy can also be determined. 根据本发明人以前的研究,每破坏约为1cm3的肿瘤块和/或肿瘤块周围的组织块,则需要大约2500焦耳的激光能。 According to the inventors previous studies, each of about 1cm3 tumor mass destruction and / or tissue surrounding the tumor mass block, you need about 2,500 joules of laser energy. (例如,参见Dowlatshahi等的“超自然乳腺肿瘤的立体定向导引激光治疗(Stereotactically Guided Laser Therapy of Occult BreastTumors)”,ARCH.SURG.,Vol.135,pp.1345-1352,Nov.2000)。 (For example, see Dowlatshahi like "supernatural guided stereotactic breast cancer laser treatment (Stereotactically Guided Laser Therapy of Occult BreastTumors)", ARCH.SURG., Vol.135, pp.1345-1352, Nov.2000). 通过计算所破坏的肿瘤块的量且假设肿瘤块的破坏量需要约2500J/cm3的激光能,则可计算破坏肿瘤块的体积所必需的激光能(J)。 By calculating the amount of tumor mass destroyed and assuming that the amount of tumor mass destruction requires approximately laser 2500J / cm3 of energy, it may be necessary for the volume of tumor mass destruction calculation of laser energy (J).

应认识到:本发明并不仅限于上述温度探测器的数目、类型、定位和位置。 It should be recognized: the present invention is not limited to the number, type, location and position of the temperature probe. 例如,根据肿瘤的治疗情况如肿瘤的类型和位置可利用多个位置和多个探测器。 For example, according to the treatment of tumors, such as tumors of the type and location of a plurality of available positions and a plurality of detectors. 在一个优选的实施例中,将温度探测器定位以有效地监控从与外部温度探测器(例如T1和T5)相应的实际肿瘤块至一定径向距离的肿瘤块破坏情况。 In a preferred embodiment, the temperature probe positioned to effectively monitor the corresponding actual tumor mass and external temperature detector (e.g., T1 and T5) to a certain radial distance of the tumor mass destruction.

还应认识到:本发明并不仅限于所述的肿瘤块破坏温度。 It should also be recognized that: the present invention is not limited to the tumor mass destruction temperature. 根据上述的肿瘤治疗情况可利用多个不同的温度而与肿瘤块破坏温度相对应。 According to the cancer treatment can take advantage of a number of different temperatures and the temperature corresponding to the tumor mass destruction. 在一个优选实施例中,优选的肿瘤块破坏温度至少为60℃。 In a preferred embodiment, the preferred tumor mass destruction temperature of at least 60 ℃.

计算机控制系统利用上述肿瘤块破坏计算公式而将被破坏的肿瘤块的图形标识提供到一个图形显示器62,如图4A所示,所述图形标识最好在治疗之前施加到实际肿瘤块的一个图像上。 Computer control system using the above formula and the destruction of tumor mass is destroyed tumor mass identification pattern to provide a graphic display 62, shown in Figure 4A, the graphical indication is preferably applied prior to treatment to an image of the actual tumor mass on. 被破坏肿瘤块的图形显示器62最好以圆形(2-D)或球形(3-D)标记显示。 Destroyed tumor mass graphics display 62 is preferably a circular (2-D) or spherical (3-D) mark display. 除了显示肿瘤块之外,还示意性地显示标识元件。 In addition to displaying the tumor mass, but also identify the elements shown schematically.

在图4B中,显示器62显示了插入肿瘤组织之后的激光探针14和温度探针16。 In Fig. 4B, the display 62 shows the laser probe is inserted into the tumor tissue after 14 and a temperature probe 16. 激光探针14的顶端64在肿瘤块40内居中布置,温度探针16依前述而相对于激光探针14布置。 The laser probe 64 of the top 14 centrally disposed within the tumor mass 40, a temperature probe 16 according to the above with respect to the laser probe 14 is arranged. 随着温度在空间中的升高及集中远离激光探针的顶端,温度探测器在T3处测量肿瘤块的破坏温度(即最好为60℃)。 As the temperature rises to the top and the focus away from the laser probe in space, the temperature detector measures a tumor mass destruction temperature at T3 (i.e., preferably 60 ℃). 在此温度下,被破坏的肿瘤块标记66就如在图4B的显示器显示的那样。 At this temperature, the destroyed tumor mass has been marked in the display 66 on the way as shown in FIG. 4B. 随着T1和T5处的温度达到上述肿瘤块破坏温度,如图4C所示,被破坏的肿瘤块标记67就扩展而包含与T1和T5相关的被破坏肿瘤块区域。 As the temperature at T1 and T5 reach the tumor mass destruction temperature above, as shown in Fig. 4C, destroyed tumor mass markers comprising 67 to expand and T1 and T5 are destroyed tumor mass region associated.

肿瘤块破坏标记从肿瘤块的实际图形处以与温度探针的外部温度探测器(例如,T1,T5)的位置相应的距离向外扩展。 Outwardly extended tumor mass destruction temperature probe labeled impose external temperature detector from the actual tumor mass graphics (e.g., T1, T5) corresponding to the position of the distance. 如图4C所示,在该距离下则有效完成了肿瘤块的破坏。 4C, in the distance is the effective completion of the destruction of the tumor mass. 所述距离在约0.25cm-约0.75cm内变化,优选在约0.4cm-0.5cm范围内变动。 The distance in about 0.25cm- about 0.75cm, preferably from changes in the scope of about 0.4cm-0.5cm. 与公知的显示情况相反,本发明的图形显示可即时且可视性地监控肿瘤块的破坏情况,公知的显示情况只是通过柱状图表来显示在不同的肿瘤块位置处的温度。 And known display contrary, the present invention graphic display for immediate and visible way to monitor tumor mass destruction, known only by a bar graph display case to show the temperature at different locations tumor mass.

在图4D、4E、4F、4G和4H中显示了对肿瘤块的破坏进行即时可视性监控而在激光治疗的开始阶段、随后阶段及终了阶段的肿瘤块破坏区的图形表征的另一个实施例。 In Fig. 4D, 4E, 4F, 4G and 4H shows the destruction of the tumor mass for instant visibility to monitor and laser treatment at the beginning, followed by another graphical representation of the stage and the end stage of the tumor mass destruction zone implementation Example. 图4D所示为没有任何破坏区的肿瘤。 Figure 4D is no tumor destruction zone. 图4E、4F和4G和4H显示了破坏区尺寸增大而扩展超过肿瘤区的情况。 Fig. 4E, 4F and 4G and 4H show the situation increases the size of the damage zone extending over the tumor area. 应认识到:可利用不同的交叉剖面线、阴影线和示意图来示意性地显示肿瘤块和破坏区。 It should be recognized: available different cross-hatching, hatching and diagrams that schematically show the tumor mass and the destruction zone. 还应认识到:可示意性地利用不同的颜色来显示肿瘤块和破坏区。 It should also be recognized that: can schematically with different colors to show the tumor mass and the destruction zone.

应认识到:可与上述示意性视图相结合来显示温度的图形标识。 It should be recognized: with a combination of the above schematic view to show the graphic temperature of identity. 图4I和4J所示为一个柱形图,该图最好提供给系统的操作者。 Fig. 4I and 4J shows a bar chart, this figure is preferably provided to the system operator. 该柱形图即时性地显示了不同位置的Tc、T1、T2、T3、T4和T5点处的温度。 The bar chart shows the real-time temperature at different locations of Tc, T1, T2, T3, T4 and T5 point. 如图4I所示,在Tc处的温度大于在T3处的温度,而在T3处的温度大于在T2和T4处的温度,在T4处的温度大于在T1和T5处的温度。 As shown in Fig. 4I, the temperature Tc is greater than the temperature at T3, T3 in temperature is greater than the temperature at T2 and T4 at a temperature greater than the temperature at T4 and T5 at T1. 随着在这些点处的肿瘤块破坏温度的升高,破坏区也增大,柱形图则即时改变为如图4J所示的一个点。 With these points in the tumor mass destruction temperature, the destruction zone increases, Column immediate change is shown as a point in Figure 4J. 在该点处,T1和T5处的区域处于肿瘤块破坏温度优选为60℃之上。 At this point, the area T1 and T5 is at a tumor mass destruction temperature is preferably above 60 ℃. 因此,操作者除可明确上述图示情况之外,还可明确已被破坏的肿瘤块的情况。 Therefore, in addition to a clear case of operator illustrated above circumstances, it can also clearly have been destroyed tumor mass.

在另一个实施例中,本发明将血液循环测试与即时可视性监控相结合来确定整个肿瘤块是何时被完全有效破坏的。 In another embodiment, the present invention will now test the blood circulation combined with real-time visibility monitoring to determine when the entire tumor mass is effectively destroyed completely. 在该实施例中可利用任何适当的血液循环测试。 In this embodiment may utilize any suitable blood circulation test. 但是,优选利用对比度增强的彩色多普勒超声检测技术,该技术使用了一种适当的对比剂和一种适当的变频超声波,从而当带有颜色的血液在肿瘤块周围的肿瘤块和组织块(即乳腺组织)中循环时,则可对带有颜色的血液进行观察。 Preferably, however, the use of contrast-enhanced color Doppler ultrasound technology, which uses a suitable contrast agent and a suitable frequency ultrasonic waves, so that when blood colored blocks tumor mass and tissue surrounding the tumor mass in (ie breast tissue) in circulation, with the color of blood can be observed. 该血液循环测试在治疗之前和治疗之后进行,且将结果进行对比以确定肿瘤块是否已被有效破坏。 The blood circulation test before treatment and after therapy, and the results are compared to determine whether the tumor mass is effectively destroyed.

在本实施例中可利用任何适当的变频器和对比剂。 In this embodiment, the drive can be used with any suitable contrast agent. 在一个优选实施例中,变频超声波是一个7.5MHz的线性阵列变频超声装置,该装置是由华盛顿Bothel的ATL生产的商用变频超声装置。 In a preferred embodiment, the ultrasonic frequency is a linear array 7.5MHz frequency ultrasound apparatus, the apparatus is a commercial frequency by the ultrasonic apparatus of ATL production Bothel, Washington.

此外,对比剂优选为一个声波降解的清蛋白制剂,即为具有气泡的一种声波降解的清蛋白制剂。 In addition, a contrast agent is preferably sonicated albumin preparation, it is having an acoustic bubble degradation albumin preparation. 应认识到:声波降解的清蛋白制剂材料中气泡的声波反射对血液流动或血液循环产生彩色反应指示。 It should be recognized: sound reflection albumin preparation material sonication of bubbles of blood flow or circulation produce a color response instructions. 特别地,该对比剂是由St.Louis,Missouri的Mallinkrodt生产的商用产品即OPTISON牌对比剂。 In particular, the contrast agent is a St.Louis, Missouri's Mallinkrodt produce commercial products namely licensing OPTISON contrast agent.

在治疗之前,优选将有效量的对比剂注入血管中。 Before treatment, an effective amount of a preferable contrast agent injected into the blood vessel. 该对比剂用来改进利用彩色多普勒超声技术产生的血液循环的图示效果。 This illustrates the effect of contrast agent used to improve the use of color Doppler ultrasound technology to produce blood circulation. 通过将图5A和5B所示的彩色多普勒超声波血液流动图进行对比来显示对比剂的效果。 By 5A and color Doppler ultrasound blood flow shown in Fig. 5B are compared to show the effect of contrast agents. 该对比剂用来产生图5B所示而非图5A所示的血液流动图。 The contrast agent is used to generate blood flow diagram shown in Figure 5B 5A rather than shown. 通过将上述视图进行对比,则可明确:与图5A所示的血流图象相比,图5B中的血液流动图像得到了改进。 By comparing the above view, you can clear: Compared with the blood flow image shown in Fig. 5A, 5B, the image of the blood flow has been improved.

转到图5B,利用对比度增强的彩色多普勒超声波检测肿瘤块和肿瘤块周围的组织块中的真实的血流量。 Go 5B, the use of contrast-enhanced color Doppler ultrasound to detect tumor mass and tissue mass surrounding the tumor mass in the real blood flow. 在治疗之后,再将对比剂喷入以观察肿瘤块内和肿瘤块周围的血液流动。 After the treatment, and then to observe the contrast agent is injected into the blood flow within the tumor mass and surrounding the tumor mass. 随着进一步的观察,如图5C所示,利用上述超声波技术所检测的肿瘤块内及其周围区域已没有有效的血液流动。 As a further observation, as shown in FIG 5C, the use of the ultrasonic technology detected tumor mass and surrounding areas has been no effective blood flow. 这就显示出:肿瘤块及肿瘤块周围的组织块已被有效破坏掉。 This shows that: the tumor mass and tissue mass surrounding the tumor mass has been effectively destroyed. 如果肿瘤块及其周围组织块已被破坏掉,则通过彩色多普勒超声装置不能有效观察到该被治疗区域内的血液循环。 If the tumor mass and surrounding tissue blocks have been destroyed, then by color Doppler ultrasound device can not effectively observe blood circulation in the treated area. 将治疗之前和治疗之后的血液循环测试结果进行比较分析以用于确定整个肿瘤块是否被破坏掉。 Before treatment and blood circulation test results after treatment were compared and analyzed for determining whether to block the entire tumor is destroyed.

在激光治疗过程中,通过将有效量的对比剂喷入血管中也可观察肿瘤块中及肿瘤块周围的血液循环内的变化。 In the laser treatment, by administering an effective amount of contrast agent injected into the blood vessel changes can be observed in the tumor mass and surrounding blood circulation within the tumor mass. 这样,在激光治疗过程中可对肿瘤块和肿瘤块周围的组织块中的血液循环进行即时监控。 Thus, in the course of laser treatment can block tumor mass and tumor tissue around the block in the blood circulation for instant monitoring. 随着越来越多的肿瘤块和肿瘤块周围的组织块被破坏掉,则流过该区域的血液也越少。 As more and more organizations block tumor mass and surrounding tumor mass is destroyed, then the blood flowing through the region are also less. 随着血液循环的降低,则可利用血液循环测试如彩色多普勒超声波测试来有效测量前面所述的血液循环中的减少量。 With reduced blood circulation, you can use a blood test cycle, such as color Doppler ultrasound tests to measure the aforementioned effective in reducing the amount of blood circulation. 这样,在激光治疗过程中可连续监控彩色多普勒超声波检测结果的图示情况。 Thus, the laser treatment process can be continuously monitored by color Doppler ultrasound illustrated case the test results. 所示图示情况可在一个独立的显示器上显示出来,或者可在激光治疗过程中添加到肿瘤块的真实图像上。 As shown in the illustrated case can be displayed on a separate monitor, or laser treatment can be added onto the real image of the tumor mass. 在将病人从平台上移开之前,该图形显示可进一步对治疗的破坏情况进行即时监控。 Before the patient is removed from the platform, the graphic display can be further treated for destruction instant monitoring. 如果目标组织的一部分显示出表征生命力的血液流动,则可进行额外的激光治疗。 If a portion of the target tissue characterization shows the vitality of the blood flow, it can perform additional laser treatment. 应认识到:可以任何适当的方式来形成图示性标识,这样就可对血液循环进行监控。 It is appreciated that: can be formed in any suitable manner diagrammatic identification, so you can monitor the blood circulation.

图6中显示了在本发明的激光治疗过程中被破坏的一个实际的肿瘤块。 Figure 6 shows an actual tumor mass in the laser treatment process of the present invention is damaged. 图中的中空区域表示由激光治疗所破坏的肿瘤块和组织块周围的区域。 FIG hollow area indicates an area of tumor mass and surrounding tissue mass destruction by the laser therapy. 如图6所示,所示中空区域基本为圆形且直径约为2.5cm-3.0cm。 As shown in Figure 6, the hollow region shown substantially circular and has a diameter of about 2.5cm-3.0cm. 图6显示了激光治疗的乳腺肿瘤的一个切面。 Figure 6 shows a section of the laser treatment of breast cancer. 红色环代表发炎区,该发炎区内的组织被破坏掉。 Red ring on behalf of inflamed area, the organization of the inflamed area was destroyed. 红色环的直径与在图5C中通过彩色多普勒超声装置所看到的无血管区的直径是相对应的。 Red ring with a diameter in Fig. 5C by color Doppler ultrasound device to see avascular zone diameter corresponding.

本发明还提供了一种用于确定被破坏肿瘤块体积的方法。 The present invention also provides a method for determining the volume of tumor mass destruction method. 该方法优选包括提供一个激光枪的步骤。 The method preferably comprises the step of providing a laser gun. 激光枪还包括上面详述的一个激光探针和一个温度探针。 Laser gun also includes a laser probe and a temperature probe as detailed above. 将激光探针和温度探针插入病人身体中,这样就将激光探针插入肿瘤块中,而将温度探针插入与肿瘤块相邻的组织块中。 The laser probe and temperature probe is inserted into a patient's body, so it will be a laser probe is inserted into a tumor mass, and the temperature probe is inserted into the tumor mass of tissue adjacent blocks. 激光枪产生有效量的激光辐射并通过激光探针送入肿瘤块中。 An effective amount of a laser gun and a laser probe laser radiation into the tumor mass. 激光探针的温度传感器对肿瘤块中的肿瘤块温度进行测量。 The laser probe temperature sensor tumor block tumor block temperature measurement. 温度探针在沿着温度探针的不同位置处测量肿瘤块周围的组织块温度。 Temperature probes measure the temperature of the tumor tissue blocks around the block at different locations along the temperature probe. 计算机控制系统优选与激光枪及其部件即激光探针、激光探针的温度传感器、温度探针和一个流体泵电动连接。 Computer control system preferably with laser guns and their components namely laser probe, laser probe of the temperature sensor, a temperature probe and a fluid pump electric connections. 如上所述,该计算机控制系统接收来自温度探针和激光探针的温度数据和激光数据以确定或计算被破坏肿瘤块的体积。 As described above, the computer control system receives temperature data from the temperature data and laser probes and laser probes to determine or calculate the volume of tumor mass destroyed. 计算机(或操作者)对流体泵输送的液体流进行调节,这样,在激光治疗过程中,肿瘤块的中心温度即Tc就不会超过100℃或低于60℃。 Computer (or operator) for pumping the liquid flow of the fluid is adjusted so that the laser treatment, i.e., the center temperature Tc of the tumor mass does not exceed 100 ℃ or below 60 ℃.

计算机控制系统利用该计算值产生一个显示图而示意性地将被破坏的肿瘤块显示到实际肿瘤块的图像上。 Computer control system uses the calculated value and generate a schematic diagram showing the destruction of the tumor mass will be displayed on the image of the actual tumor mass. 通过示意性地显示被破坏的肿瘤块的量,就如前面的内容所述,医生就可即时且可视性地监控肿瘤块所破坏情况,从而确定肿瘤块是何时被有效破坏掉的。 By schematically shows the amount of tumor mass destroyed, as the contents of the foregoing, the doctor can monitor real-time visibility into the tumor mass and the destruction, in order to determine when the tumor mass was effectively destroyed in.

在另一个实施例中,本发明的方法包括在将激光枪插入肿瘤块之前对肿瘤块进行辨识的步骤。 In another embodiment, the method of the present invention includes the steps prior to the laser gun to insert the tumor mass identification of tumor blocks. 利用常用的X光线摄影技术、超声诊断技术或电磁成像技术来进行该辨识步骤。 By conventional X-ray photography, ultrasound diagnostic techniques or electromagnetic imaging techniques for the identification procedure. 优选利用前述的立体定向技术或类似技术确定用于辨识肿瘤块实际位置的坐标。 Preferably using the aforementioned stereotactic technique or the like to determine the coordinates of the identification of the actual location of a tumor mass.

在另一个实施例中,本发明在治疗之前及治疗之后利用了一个血液循环测试例如彩色多普勒超声检测装置来进一步证实整个肿瘤块是在何时被有效破坏掉的,该内容已在前面的内容中进行了描述。 In another embodiment, the present invention prior to treatment and after treatment utilizes a blood circulation test such as color Doppler ultrasound detection means further confirmed when the entire tumor mass is effectively destroyed, and that the content is in front The contents are described. 如上所述,在激光治疗过程中也可利用血液循环测试以对肿瘤块的破坏情况进行即时监控。 As described above, in the laser treatment of the blood circulation test can also be used to block the destruction of the tumor were real-time monitoring.

应认识到:本发明并不仅限于间隙式激光治疗,特别是对乳腺肿瘤进行破坏的激光治疗。 It should be recognized: the present invention is not limited to laser treatment gap, especially breast cancer laser treatment failure. 本发明可用于对多种不同肿瘤块进行破坏的不同形式的非外科治疗。 The present invention can be used for non-surgical treatment of various forms of many different tumor blocks destruction.

应认识到:在不脱离本发明的范围和新颖内容的情况下可对本发明进行变更和变化,还应认识到本申请只受到附加的权利要求的范围的限制。 It should be recognized: without departing from the scope and content of the present invention the novel circumstances of the present invention may be modified and changes should also be appreciated that the present application is limited only by the appended claims range.

应认识到:对本申请所述的优选实施例所作发改变和变更对于本领域的人员来说是很明确的。 It should be recognized: hair changes and modifications made to the person skilled in the art that it is clear of the preferred embodiments described herein. 在不脱离本发明的精神实质和范围的情况下且在不消除本申请的优势的情况下即可作出所述变更和变化。 The modifications and changes can be made in the case, without departing from the spirit and scope of the present invention does not eliminate the advantage of the situation and in the present application. 因此,附加的权利要求也覆盖这些变更和变化。 Therefore, the appended claims cover such modifications and variations also.

Classifications
International ClassificationA61B6/04, A61B18/20, A61B18/24, A61B8/06, A61B5/05, A61B6/00, A61B5/01, A61B19/00, A61N5/06, A61B5/00, A61B18/00, A61B5/06, A61B17/00
Cooperative ClassificationA61B5/064, A61B2018/2005, A61B5/01, A61B18/20, A61B6/0414, A61B2018/00011, A61B6/502, A61B5/06, A61B2017/00084, A61B2018/206, A61B8/06, A61N5/0601, A61B2090/063
European ClassificationA61N5/06B, A61B18/20, A61B5/06
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Owner name: NOVI HEALTHY CO., LTD.
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