CN1248156A - 多层复合管状结构及其制造方法 - Google Patents

多层复合管状结构及其制造方法 Download PDF

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CN1248156A
CN1248156A CN97181483.XA CN97181483A CN1248156A CN 1248156 A CN1248156 A CN 1248156A CN 97181483 A CN97181483 A CN 97181483A CN 1248156 A CN1248156 A CN 1248156A
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tubular structure
multilayer composite
composite tubular
pipe
formation
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CN1173674C (zh
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J·K·埃克尔特
J·M·法里纳
J·P·加达
J·C·克利
J·G·托马斯
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STENT TECHNOLOGIES Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/01—Layered products comprising a layer of metal all layers being exclusively metallic
    • C—CHEMISTRY; METALLURGY
    • C21—METALLURGY OF IRON
    • C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D8/00—Modifying the physical properties by deformation combined with, or followed by, heat treatment
    • C21D8/10—Modifying the physical properties by deformation combined with, or followed by, heat treatment during manufacturing of tubular bodies
    • C21D8/105—Modifying the physical properties by deformation combined with, or followed by, heat treatment during manufacturing of tubular bodies of ferrous alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
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    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
    • C—CHEMISTRY; METALLURGY
    • C21—METALLURGY OF IRON
    • C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D2251/00—Treating composite or clad material
    • C21D2251/02—Clad material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/12292—Workpiece with longitudinal passageway or stopweld material [e.g., for tubular stock, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/12819—Group VB metal-base component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/12861—Group VIII or IB metal-base component
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

一用作一外科手术中移植件的多层复合管状结构,具有一生物相容性材料的外层(12)、一非透射性材料的中间层(14)和一生物相容性材料的内层(16)。这些层料被冶金法粘接,以形成一易延展的复合移植件(10),并且允许该复合移植件有大的变形而在生物相容性层(12,16)与非透射性层(14)之间不会发生分层。所形成的复合结构(10)在一荧光屏上是可见的,并且不会遮蔽移植件(10)本身的细节、或者绕移植件(10)周围的解剖器官。还公开了形成一多层复合管状结构(10)的方法。将一生物相容性材料管(12,16)同轴地环绕由非透射性材料所形成的一管(14)。例如通过管拉伸、模锻或深拉伸来同时减小这些管料结构,直到形成所希望的直径和壁厚。然后对这些管件进行热处理,以使生物相容性层(12,16)与非透射性层(14)扩散粘接。

Description

多层复合管状结构及其制造方法
本发明涉及多层复合管领域，尤其是用于外科手术中的移植件。本发明提供一用作一外科手术移植件的多层复合管状结构，其在一荧光屏上是可见的，但不会屏蔽解剖结构。本发明还提供一种在配置(deployment)和膨胀时不会分层的多层移植件。
已经在大量的外科手术中采用移植件。例如，在有序的治疗过程中采用移植件来修复和支承受损的组织。将移植件植入目标位置并且膨胀到其原始直径的几倍，直到该移植件接触周围组织。该过程称为移植件的初始膨胀。接着，移植件进一步膨胀，以使其埋入周围解剖结构的壁内，例如一动脉内。该过程称为埋置(imbedding)。初始膨胀与埋置的过程称为配置(deployment)。一旦移植件膨胀，其即处于一固定位置。
一包括使用一移植件的普通外科手术的例子是在从冠状动脉内去除溶菌斑后，将一移植件植入该动脉内。在该情形中，移植件用来支承已被动脉粥样硬化溶菌斑阻塞的血管。
移植件也用于包括输尿管和尿道的外科手术中。例如，在前列腺外科术中，移植件用来保持泌尿系统管道的通畅。
在所有例如上述外科手术中，移植件的放置与定位是至关重要的。因此已开发了允许一内科医师或外科医生观察一移植件位置的各种方法，以正确地植入。这些方法中最常见的是使用一(x射线)荧光检查仪观察植入物。
现有技术的移植件通常是由例如不锈钢、钽或(镍钛金属互化物)NitinolTM的单一金属制造，其中最常用的材料是不锈钢。不锈钢移植件的一主要缺陷是其对于荧光屏是透明的。因此，采用不锈钢移植件需要在血流中注入不透明的染料，以使外科医生能看见移植件来进行定位和配置。这些染料消散得非常快，使得只能在短暂的时间内看到该移植件。因此，包括不锈钢移植件的手术和使用染料来观察移植件要求快速地选位和配置移植件。此外，移植件的缺乏可见性使得即使并非不可能、但也极为困难来验证移植件是否在一段时间后已改变位置。
钽是移植件中广泛使用的一非透射性材料。一固体钽移植件必须具有一在配置和功能方面均有用的最小厚度。固体钽移植件所需的厚度导致一在荧光屏上的高的发光度，而这会引起一些问题。(问题之)一是由钽移植件产生的荧光屏图像太亮，以至于消除了移植件图案的细节和移植件/脉管交界处的细节。因为不可能看到移植件/脉管交界处，因此准确地将移植件放置到脉管分枝中是费事的。此外，移植件不能被准确地观察到的事实使得更难以确定在移植件位置是否已出现例如再狭窄的脉管状态。
因为在各种解剖位置使用移植件，需要改变移植件的厚度，因而改变其强度，以弥补解剖的不同。例如，可以在具有不同程度肌肉量的解剖位置使用移植件。一多层移植件应当能弥补肌肉量的变化，例如采用不同厚度的移植件层。另外，还希望能改变一移植件的发光度，以弥补不同的解剖变化和不同程度的肌肉量。
外科手术移植件在配置过程中承受极大的塑性变形。在一多层移植件中，移植件的层必须不分层或分离。一多层移植件的任何分层将会产生粗糙的或尖锐的边缘，导致血栓症，和(导致)直接的解剖损伤，包括撕裂脉管。
外科手术实践中通常采用一气球单元来配置、膨胀和埋置外科手术移植件。在移植件技术中采用这些气球单元是公知的。采用一气球单元来膨胀一外科手术移植件，所用的压力是关键性的。需要一较高的压力来膨胀的移植件会带来增大的气球破裂的危险，而破裂会导致一栓塞。
因此，需要一种在一荧光屏上可见而又不屏蔽解剖结构的移植件。
还需要一种可以膨胀而不分层的多层移植件。
还需要一种可通过改变其厚度来改变强度的多层移植件，以适应不同的解剖结构。
还需要一种可通过改变移植件层的厚度来改变其在荧光屏上的发光度的多层移植件，以适应不同的解剖结构。
还需要一种在一较低的压力下膨胀的移植件和当配置时提供气球破裂的危险减少的多层移植件。
本发明涉及一种能满足一移植件下列需要的结构：既可在一荧光屏上可见，又不遮蔽移植件本身或者围绕移植件周围的解剖结构的细节。本发明给这些需要提供了一确实创新和有效的解决方案。
一具有本发明特征的结构包括一多层复合移植件。该移植件的一层是由一非透射性材料形成。移植件的另一层是由一生物相容性材料形成。这些层的组合产生一种既生物相容、又在一荧光屏上可见，同时还不屏蔽移植件结构或周围的解剖结构的结构。
本发明还提供一种制造具有上述移植件特性之多层复合结构的方法。一作为本发明主题的多层复合结构是这样产生的：例如通过管拉伸、模锻或深拉伸一作为复合物的多重管或条带来使之减小，并且进行热处理来扩散粘接这些层。这导致一易延展的结构，其允许有大的变形而在生物相容性层与非透射性层之间不会分层。
为描述本发明，在附图中示出一目前较优的方式；但应当理解本发明并不限于所示的具体配置和手段。
图1表示一根据本发明的移植件在蚀刻或加工前的局部透视图。
图2表示一沿图1的2-2线剖取的横剖视图，示出了移植件的诸层。
图3是一根据本发明的实际移植件在蚀刻或加工后一部分的电子显微图。
图4表示一根据本发明另一实施例的移植件在蚀刻或加工前的一分解局部剖开图。
图5是一沿图4的5-5线剖取的横剖视图，表示移植件的诸层。
图6是一根据本发明的移植件的另一实施例的横剖视图，表示一在层之间的金属夹片。
图7～9是一根据本发明制造一移植件的方法之局部剖视图。
图10是一根据本发明的移植件设置在一动脉内的横剖视图。
图11是一根据本发明的移植件在膨胀前的侧视图。
现参照附图，其中相同的标记表示相同的元件，在图1和2中示出了根据本发明的一移植件10。在图1、2和3所示的本发明的优选实施例中，一移植件10包括一多层复合管状结构，其中，一外层12为生物相容性材料，一中层14为非透射性材料，一内层16也为生物相容性材料。在该优选实施例中，用于外层12和内层16的生物相容性材料是不锈钢，而非透射性中层14为钽。这些层材用下述方法粘结(bond)在一起。图3所示的移植件10已被蚀刻和加工成一定的型式。
应认识到可用其它生物相容性材料来代替不锈钢。还应当认识到非透射性层14也不限于钽，而是可采用包括但不限于金、铂、和这些材料的合金之类的其它材料，这些均在本发明的范围之内。
在一不锈钢-钽-不锈钢的移植件、例如移植件10中，钽层14必须具有足够的厚度，以在一荧光屏(未示出)上提供一亮丽和清晰的图像。非透射性钽层14的厚度可以变化，以给脉管内靠近表面植入移植件的地方提供最优的发光效果，此时需要较低的发光，而对于例如肌肉组织内较深位置的手术，则需要较高的发光，因此就需要一较厚的非透射性钽层14。非透射性钽层14的厚度也可改变来适应具有不同组织密度的解剖位置，因为这些位置需要不同的移植件发光效果。
在本发明的另一实施例中，如图4和5所示，薄的非透射性层24可以通过电镀、蒸发、化学或其它薄膜沉积技术沉积在一生物相容性材料制成的第一管材28的外表面26上。在图4和5中，为清晰起见，非透射性层24的相对厚度被夸大了。涂层的第一管材28然后被冶金方式粘结到一第二管材30上，如下所述在非透射性层24与第二管30之间形成一扩散层18。在另一实施例中，非透射性层24被沉积在一第一管(未示出)的内表面上，然后该第一管被同轴地设置和冶金方式粘结到一第二管上。
因此非透射性层14或24的厚度可以为移植件10壁厚的1％～95％。这样，发光效果可以很宽地变化，以适应不同的组织变化。
可以在本发明的移植件上增加附加的层，以形成各种合成移植件。例如，可形成一5层移植件，具有交替的不锈钢层和钽层，其中不锈钢层为最外层和最里层。
由于移植件10在配置和膨胀过程中必然会出现大的塑性变形，如前所述，因此不锈钢层与钽层之间所形成的粘接效果对于结构的功能是至关重要的。一机械粘接不足以满足根据本发明的移植件的要求。而是，一种发生材料成分扩散的冶金法粘接是所希望的方案。该冶金法粘接是通过向材料施加压力和热能形成的，正如下面所要描述的。
如图2所述，在结构的层之间形成一冶金法粘接的同时，在相邻的层12与14、或者14与16之间的交界面处还设置一扩散层18。通过适当的热处理周期可以有效地影响和控制这些扩散层18的特性，导致一所希望的易延展的(柔软的)扩散层18，或者一不希望的易碎的(脆化的)金属中间层。
热处理、温度和时间关系可控制扩散元素的传输速率，导致在扩散层18内具有不同的元素成分和厚度。热处理周期对于不同的材料组合必须是优化的，从而扩散层18保持配置所需的易延展性。扩散层18还必须是，在确保粘接完整性和确保在移植件10配置而膨胀的过程中防止分层的易延展性前提下所需的最小厚度。
在本发明的另一实施例中，如图6所示，将可能不易相容并且将导致形成一不希望的易碎金属中间层的材料粘接在一起，可以通过使用一金属夹片20来完成。该夹片20用于同时控制通过扩散区22传输的扩散速率和元素。例如，可采用一金制夹片来便于形成一适当的扩散层18。
可采用下列方法来形成具有本发明特征的一多层复合管状结构。
例1
如前所提及，不锈钢与钽之间的扩散层18是通过适当施加压力和热处理来建立和控制的。这在扩散粘接的领域是周知的。在一形成本发明所采用的方法例子中，同轴地设置一由生物相容性材料制造的外管、一由非透射性材料制造的中管和一由生物相容性材料制造的内管，并且例如通过模锻或管拉伸来同时减小这些管料。这种方式的管减小方法是周知的。以这种方法配置的一复合管状结构的例子表示在图1和3中。
在根据本发明的多层复合管状结构中，在层之间交界处的压力是由在复合拉伸操作后余留在管内的残余径向夹紧应力的结果所形成的。在管拉伸领域的普通技术人员将知道，增大面积缩减量和改变面积缩减量相对于壁厚缩减量的百分比，会增大或降低在一定限度内该残余应力的幅度。
在该方法的一例子中，如上所述设置一不锈钢外管、一钽中管和一不锈钢内管来形成复合结构。为便于层之间的正确粘接，应当在交界处建立一至少50p.s.i(磅/平方英寸)的残余夹紧应力。此外，必须在一有限的时间和温度范围内对复合管进行退火处理。该时间和温度范围的下限应当至少为1550华氏度和至少6分钟。上限不应超过1850华氏度和15分钟。在该温度范围内复合管的退火将会产生一最小厚度的扩散层和保持所需易延展性的基本成分，以允许在较低压力下配置和膨胀，并且仍然可防止在膨胀过程中分层。
例2
在形成本发明的另一方法中，在一生物相容性材料内管的外表面上沉积一非透射性材料层。该配置示于图4中。可以通过诸如蒸发沉积、电镀、喷涂或类似方法的一覆层(涂覆)方法来沉积该非透射性材料。然后绕该覆层内管设置一生物相容性材料外管。
然后一起拉伸复合管并且逐渐减小，直到获得所希望的残余夹紧应力，如上所述。然后如上所述对该管进行热处理，在非透射性层与外管的内表面之间形成一扩散粘接。
通过在外管的内表面上沉积非透射性层、并且将这一组合结构粘接到内管的外表面上都可完成该同样的过程。
例3
可用来形成一多层复合管状结构的另一方法包括使用一金属夹片20。该方法示于图6中。夹片20被设置在生物相容性层与非透射性层之间，并且用来控制通过扩散区传输的扩散速率和/或扩散微粒。然后一起拉伸并且逐渐减小这些多层管，直到获得所希望的残余夹紧应力，如上所述。然后如上所述对管进行热处理，以在非透射性材料与生物相容性材料之间形成一扩散粘接结构，这由夹片20而获得制做上的便利。
例4
可用来形成一根据本发明的多层复合管状结构之另一方法包括采用由一多层条带42进行深拉伸的步骤。深拉伸方法在管形成技术中是周知的。
在一实施例中，如图7、8和9所示，多层条带具有一不锈钢顶层54、一非透射性材料中层56和一不锈钢底层58。该条带42是在深拉伸处理之前通过冶金法粘接诸层而制备的。在深拉伸处理的过程中，如图8所示，条带42被放置到一冲模44上，并且条带42例如被一冲头46压入该冲模44内。在冲模44内就形成一具有一封闭端50的一定壁厚的管材48。采用一系列直径渐减的冲模重复该过程，直到形成一具有所希望的直径和壁厚的多层管48。对于一定的材料组合，可能需要在逐渐拉伸操作中进行中间热处理，如上所述。一旦形成一所希望厚度和尺寸的管材，就切掉管48的封闭端50和弯曲边缘52，如图9所示。然后，如上所述对管件进行热处理，直到在层之间形成适当的金属间粘接。
一此处所述的复合结构的优点是，对于一宽范围的非透射性层厚度和材料，移植件10可以在一较小施加的力下扩张，与同样厚度的一固体不锈钢移植件所需的压力相比，这会传递较低的配置压力。这是因为复合结构的较低的模量。该较低的模量是由非透射性材料的较低的弯曲强度和/或较低的疲劳应变硬化率造成的。
在一使用一移植件的典型的外科手术中，用一低压气球(未示出)来使移植件进行初始膨胀，直到移植件壁接触一被打开的脉管，例如一动脉的壁为止。图10中所示的一移植件10与一动脉11的壁保持接触。然后撤除低压气球，插入一高压气球(未示出)，并且该移植件10被高压气球进一步膨胀开，进入动脉壁11内。该第二次膨胀是指“埋置”。与同样厚度的普通不锈钢移植件相比，具有一种1∶1∶1的不锈钢∶钽∶不锈钢比率的复合移植件的膨胀和埋置压力详细示于表1：
表1
  不锈钢     多层复合物1∶1∶1(不锈钢∶钽∶不锈钢)
    配置   4个大气压     3.5个大气压
 膨胀(埋置)   8个大气压     7个大气压
与固体不锈钢移植件相比，给复合移植件采用较低膨胀和埋置压力的能力可控制其安全与可靠性。由于需要较低的压力来膨胀和埋置本发明的复合移植件，因此撕裂或损伤解剖的器官、组织或脉管周围的风险较小。此外，在气球单元上施加的应力较低，因此降低了气球破裂的危险和伴随的栓塞危险。
本发明可以具体化为其它特定的方式而不脱离其实质或基本特征，因此在确定本发明的保护范围时，应当参照所附的权利要求书而不是前述说明书。

Claims (57)

1.一用作一外科手术中之移植件的多层复合管状结构，包括：
(a)一包括一生物相容性材料的外层；
(b)一包括冶金法粘接到该外层的一非透射性材料的中间层；和
(c)一包括冶金法粘接到该中间层的一生物相容性材料的内层。
2.如权利要求1所述的多层复合管状结构，其特征是该外层是不锈钢料。
3.如权利要求1所述的多层复合管状结构，其特征是该内层是不锈钢料。
4.如权利要求1所述的多层复合管状结构，其特征是该中间层是包括钽、金、金合金、铂和铂合金的组中的一种。
5.如权利要求1所述的多层复合管状结构，其特征是该非透射性层的厚度被选择成在一荧光屏上产生预选的发光效果。
6.一用作一外科手术中之移植件的多层复合管状结构，包括：
(a)一生物相容性材料的外管；
(b)一生物相容性材料的内管，该内管具有一沉积在其外表面上的非透射性材料层，该非透射性层被冶金法粘接到外管上。
7.如权利要求6所述的多层复合管状结构，其特征是该非透射性材料是通过包括蒸发沉积、电镀和喷射的组中的一种(方法)沉积到内管的外表面上的。
8.如权利要求6所述的多层复合管状结构，其特征是该外管由不锈钢形成的。
9.如权利要求6所述的多层复合管状结构，其特征是该内管由不锈钢形成的。
10.如权利要求6所述的多层复合管状结构，其特征是该非透射性层是包括钽、金、金合金、铂和铂合金的组中的一种。
11.如权利要求6所述的多层复合管状结构，其特征是该非透射性层的厚度被选择成在一荧光屏上产生预选的发光效果。
12.一用作一外科手术中移植件的多层复合管状结构，包括：
(a)一生物相容性材料的外管，该外管具有一沉积在其内表面上的非透射性材料层；
(b)一生物相容性材料的内管，该非透射性层被冶金法粘接到该内管上。
13.如权利要求12所述的多层复合管状结构，其特征是该非透射性材料是通过包括蒸发沉积、电镀和喷射的组中的一种(方式)沉积到外管的内表面上的。
14.如权利要求12所述的多层复合管状结构，其特征是该外管由不锈钢形成。
15.如权利要求12所述的多层复合管状结构，其特征是该内管由不锈钢形成。
16.如权利要求12所述的多层复合管状结构，其特征是该非透射性层是包括钽、金、金合金、铂和铂合金的组中的一种。
17.如权利要求12所述的多层复合管状结构，其特征是该非透射性层的厚度被选择成在一荧光屏上产生预选的发光效果。
18.一用作一外科手术中之移植件的多层复合管状结构，包括一非透射性材料层，一生物相容性材料层和一在该非透射性材料与生物相容性材料之间合适的金属夹片。
19.如权利要求18所述的多层复合管状结构，其特征是该金属夹片是由金形成的。
20.如权利要求18所述的多层复合管状结构，其特征是该非透射性层的厚度被选择成在一荧光屏上产生预选的发光效果。
21.一形成用作一外科手术中之移植件的多层复合管状结构的方法，包括：
(a)将一生物相容性材料管同轴地环绕一非透射性材料管；
(b)将这些管同时减小到一所希望的直径并由此在管之间产生一残余夹紧应力；
(c)对管进行热处理，以形成这些管的扩散粘接，从而所形成的复合管是易延展的，并且允许变形而在非透射性材料与生物相容性材料之间不会分层。
22.如权利要求21所述的形成一多层复合管状结构的方法，其特征是通过管拉伸和模锻步骤之一来减小该层件。
23.如权利要求21所述的形成一多层复合管状结构的方法，其特征是残余夹紧应力至少为50p.s.i(磅/平方英寸)。
24.如权利要求21所述的形成一多层复合管状结构的方法，其特征是至少在1550华氏度的一温度下加热。
25.如权利要求21所述的形成一多层复合管状结构的方法，其特征是在不超过1850华氏度的一温度下加热。
26.如权利要求21所述的形成一多层复合管状结构的方法，其特征是加热6～15分钟。
27.如权利要求21所述的形成一多层复合管状结构的方法，其特征是在大约1550～约1850华氏度的温度范围内加热6～15分钟。
28.一形成用作一外科手术中之移植件的多层复合管状结构的方法，包括：
(a)在一第一管的外表面上沉积一非透射性层，该第一管是由生物相容性材料形成的；
(b)将一由生物相容性材料形成的第二管同轴地环绕该第一管；
(c)将这些管料同时减小到一所希望的直径并由此在管料之间产生一残余夹紧应力；
(d)对该管料进行热处理，以使非透射性层扩散粘接到外管上，从而形成一易延展的复合管，并且允许该复合管变形而在非透射性材料与生物相容性材料之间不会分层。
29.如权利要求28所述的形成一多层复合管状结构的方法，其特征是非透射性材料是通过包括蒸发沉积、电镀和喷射的组中的一种(方法)沉积到第一管的外表面上的。
30.如权利要求28所述的形成一多层复合管状结构的方法，其特征是通过管拉伸和模锻步骤之一来减小管料结构。
31.如权利要求28所述的形成一多层复合管状结构的方法，其特征是残余夹紧应力至少为50p.s.i(磅/平方英寸)。
32.如权利要求28所述的形成一多层复合管状结构的方法，其特征是至少在1550华氏度的一温度下加热。
33.如权利要求28所述的形成一多层复合管状结构的方法，其特征是在不超过1850华氏度的一温度下加热。
34.如权利要求28所述的形成一多层复合管状结构的方法，其特征是加热6～15分钟。
35.如权利要求28所述的形成一多层复合管状结构的方法，其特征是在大约1550～约1850华氏度的温度范围内加热6～15分钟。
36.一形成用作一外科手术中之移植件的多层复合管状结构的方法，包括：
(a)在一生物相容性材料的第一管的内表面上沉积一非透射性层；
(b)将该第一管同轴地环绕一生物相容性材料的第二管；
(c)将这些管料结构同时减小到一所希望的直径并由此在管料之间产生一残余夹紧应力；
(d)对管料结构进行热处理，以使非透射性层与外管的内表面扩散粘接，其中所形成的复合管是易延展的，并且允许该复合管变形而在非透射性材料与生物相容性材料之间不会分层。
37.如权利要求36所述的形成一多层复合管状结构的方法，其特征是非透射性材料是通过包括蒸发沉积、电镀和喷射的组中的一种(方法)沉积到第一管的内表面上的。
38.如权利要求36所述的形成一多层复合管状结构的方法，其特征是通过管拉伸和模锻步骤之一来减小管料结构。
39.如权利要求36所述的形成一多层复合管状结构的方法，其特征是残余夹紧应力至少为50p.s.i。
40.如权利要求36所述的形成一多层复合管状结构的方法，其特征是至少在1550华氏度的一温度下加热。
41.如权利要求36所述的形成一多层复合管状结构的方法，其特征是在不超过1850华氏度的一温度下加热。
42.如权利要求36所述的形成一多层复合管状结构的方法，其特征是加热6～15分钟。
43.如权利要求36所述的形成一多层复合管状结构的方法，其特征是在大约1550～约1850华氏度的温度范围内加热6～15分钟。
44.一形成用作一外科手术中之移植件的多层复合管状结构的方法，包括：
(a)用一生物相容性材料的管同轴地环绕一非透射性材料的管；
(b)将一金属夹片设置在该非透射性管与生物相容性管之间；
(c)将这些管料结构同时减小到一所希望的直径并由此在管料之间产生一残余夹紧应力；
(d)对管科结构进行热处理，以使非透射性层与生物相容性层扩散粘接，从而所形成的复合管是易延展的，并且允许该复合管变形而不会分层。
45.如权利要求44所述的形成一多层复合管状结构的方法，其特征是通过管拉伸和模锻步骤之一来减小层结构。
46.如权利要求44所述的形成一多层复合管状结构的方法，其特征是残余夹紧应力至少为50p.s.i。
47.如权利要求44所述的形成一多层复合管状结构的方法，其特征是至少在1550华氏度的一温度下加热。
48.如权利要求44所述的形成一多层复合管状结构的方法，其特征是在不超过1850华氏度的一温度下加热。
49.如权利要求44所述的形成一多层复合管状结构的方法，其特征是加热6～15分钟。
50.如权利要求44所述的形成一多层复合管状结构的方法，其特征是在大约1550～约1850华氏度的温度范围内加热6～15分钟。
51.一形成用作一外科手术中之移植件的多层复合管状结构的方法，包括：
(a)将一具有一非透射性材料层和一生物相容性材料层的条带放置到一冲模上；
(b)通过一系列的冲模深拉伸该条带来减小所述条带，从而在层结构之间产生一夹紧应力并且形成一具有一封闭端的所需壁厚的管料结构；
(c)一旦获得所需的壁厚，就切除管的封闭端；和
(d)对管件进行热处理，以使非透射性层与生物相容性层扩散粘接，从而所形成的复合管是易延展的，并且允许该复合管变形而在非透射性层与生物相容性层之间不会分层。
52.如权利要求51所述的形成一多层复合管状结构的方法，其特征是残余夹紧应力至少为50p.s.i。
53.如权利要求51所述的形成一多层复合管状结构的方法，其特征是至少在1550华氏度的一温度下加热。
54.如权利要求51所述的形成一多层复合管状结构的方法，其特征是在不超过1850华氏度的一温度下加热。
55.如权利要求51所述的形成一多层复合管状结构的方法，其特征是加热6～15分钟。
56.如权利要求51所述的形成一多层复合管状结构的方法，其特征是在大约1550～约1850华氏度的温度范围内加热6～15分钟。
57.一种设置一用作外科手术中之移植件的多层复合管状结构的方法，包括：
(a)将该结构配置到一解剖位置；
(b)用一不大于3.5个大气压压力的气球来使该结构膨胀，直到该结构的壁接触解剖位置处的组织；和
(c)通过用一大于7.5个大气压压力的气球进一步膨胀该结构，使该结构埋置到解剖位置处的所述组织内。
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100436119C (zh) * 2000-02-03 2008-11-26 纳幕尔杜邦公司 冶金结合的具有弯曲表面的层状制品
CN102429750A (zh) * 2011-08-15 2012-05-02 微创医疗器械(上海)有限公司 改进显影性能的血管支架及增强血管支架显影性能的方法
CN104454415A (zh) * 2014-12-10 2015-03-25 北京航空航天大学 一种闸线式形状记忆合金驱动器
CN106937894A (zh) * 2017-03-16 2017-07-11 贵州医科大学附属医院 增强血管支架显影性能的显影标志、血管支架和方法
CN107184291A (zh) * 2011-10-07 2017-09-22 W.L.戈尔及同仁股份有限公司 可刺穿又可再密封的移植物
CN107361880A (zh) * 2017-06-20 2017-11-21 西安交通大学 一种仿生颈动脉血管的制备方法
CN108325047A (zh) * 2018-03-26 2018-07-27 青岛市中心医院 一种体外导向心导管装置
CN108723711A (zh) * 2018-05-24 2018-11-02 上海天阳钢管有限公司 一种制造复合油井管的工艺方法
CN108747214A (zh) * 2018-05-24 2018-11-06 上海天阳钢管有限公司 一种制造带节箍的复合油井管的工艺方法

Families Citing this family (278)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101392B2 (en) * 1992-03-31 2006-09-05 Boston Scientific Corporation Tubular medical endoprostheses
US6497709B1 (en) 1992-03-31 2002-12-24 Boston Scientific Corporation Metal medical device
JPH07505316A (ja) * 1992-03-31 1995-06-15 ボストン　サイエンティフィック　コーポレーション 医療用ワイヤ
US5630840A (en) 1993-01-19 1997-05-20 Schneider (Usa) Inc Clad composite stent
US20050059889A1 (en) * 1996-10-16 2005-03-17 Schneider (Usa) Inc., A Minnesota Corporation Clad composite stent
US6039749A (en) 1994-02-10 2000-03-21 Endovascular Systems, Inc. Method and apparatus for deploying non-circular stents and graftstent complexes
US6329069B1 (en) * 1995-07-26 2001-12-11 Surface Genesis, Inc. Composite structure and devices made from same and method
AU707727B2 (en) * 1995-08-24 1999-07-15 Impra, Inc. Covered endoluminal stent and method of assembly
US5800512A (en) * 1996-01-22 1998-09-01 Meadox Medicals, Inc. PTFE vascular graft
US6027528A (en) * 1996-05-28 2000-02-22 Cordis Corporation Composite material endoprosthesis
US6099561A (en) * 1996-10-21 2000-08-08 Inflow Dynamics, Inc. Vascular and endoluminal stents with improved coatings
US8663311B2 (en) 1997-01-24 2014-03-04 Celonova Stent, Inc. Device comprising biodegradable bistable or multistable cells and methods of use
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
DE19720115C2 (de) * 1997-05-14 1999-05-20 Jomed Implantate Gmbh Stent-Graft
US6070589A (en) 1997-08-01 2000-06-06 Teramed, Inc. Methods for deploying bypass graft stents
NO311781B1 (no) * 1997-11-13 2002-01-28 Medinol Ltd Flerlags-stenter av metall
WO1999026559A1 (en) * 1997-11-25 1999-06-03 Triad Vascular Systems, Inc. Layered endovascular graft
US6296633B1 (en) * 1998-01-09 2001-10-02 Schneider (Usa) Inc. Medical device tubing assembly and method of making the same
US6395019B2 (en) * 1998-02-09 2002-05-28 Trivascular, Inc. Endovascular graft
US6290731B1 (en) 1998-03-30 2001-09-18 Cordis Corporation Aortic graft having a precursor gasket for repairing an abdominal aortic aneurysm
US7500988B1 (en) 2000-11-16 2009-03-10 Cordis Corporation Stent for use in a stent graft
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US6248190B1 (en) * 1998-06-15 2001-06-19 Scimed Life Systems, Inc. Process of making composite stents with gold alloy cores
US6387060B1 (en) * 1998-06-17 2002-05-14 Advanced Cardiovascular Systems, Inc. Composite radiopaque intracorporeal product
US6206915B1 (en) * 1998-09-29 2001-03-27 Medtronic Ave, Inc. Drug storing and metering stent
US6419806B1 (en) 1998-12-03 2002-07-16 Tosoh Smd, Inc. Insert target assembly and method of making same
WO2000048530A1 (en) * 1999-02-16 2000-08-24 Talison Research, Inc. Multilayer and multifunction vascular graft
US6620192B1 (en) * 1999-03-16 2003-09-16 Advanced Cardiovascular Systems, Inc. Multilayer stent
US6364903B2 (en) 1999-03-19 2002-04-02 Meadox Medicals, Inc. Polymer coated stent
US6464723B1 (en) 1999-04-22 2002-10-15 Advanced Cardiovascular Systems, Inc. Radiopaque stents
US6890350B1 (en) 1999-07-28 2005-05-10 Scimed Life Systems, Inc. Combination self-expandable, balloon-expandable endoluminal device
US6283357B1 (en) * 1999-08-03 2001-09-04 Praxair S.T. Technology, Inc. Fabrication of clad hollow cathode magnetron sputter targets
US6585757B1 (en) 1999-09-15 2003-07-01 Advanced Cardiovascular Systems, Inc. Endovascular stent with radiopaque spine
US6387123B1 (en) 1999-10-13 2002-05-14 Advanced Cardiovascular Systems, Inc. Stent with radiopaque core
US6733513B2 (en) 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US6475235B1 (en) 1999-11-16 2002-11-05 Iowa-India Investments Company, Limited Encapsulated stent preform
US7300457B2 (en) * 1999-11-19 2007-11-27 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same
US20060052865A1 (en) * 2004-09-09 2006-03-09 Banas Christopher E Stents with metallic covers and methods of making same
US6379383B1 (en) 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
US8458879B2 (en) 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
US6936066B2 (en) * 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US7736687B2 (en) * 2006-01-31 2010-06-15 Advance Bio Prosthetic Surfaces, Ltd. Methods of making medical devices
US10172730B2 (en) * 1999-11-19 2019-01-08 Vactronix Scientific, Llc Stents with metallic covers and methods of making same
US6537310B1 (en) 1999-11-19 2003-03-25 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal implantable devices and method of making same
US7235092B2 (en) * 1999-11-19 2007-06-26 Advanced Bio Prosthetic Surfaces, Ltd. Guidewires and thin film catheter-sheaths and method of making same
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6508832B1 (en) * 1999-12-09 2003-01-21 Advanced Cardiovascular Systems, Inc. Implantable nickel-free stainless steel stents and method of making the same
US6471721B1 (en) * 1999-12-30 2002-10-29 Advanced Cardiovascular Systems, Inc. Vascular stent having increased radiopacity and method for making same
US6245100B1 (en) 2000-02-01 2001-06-12 Cordis Corporation Method for making a self-expanding stent-graft
US6296661B1 (en) 2000-02-01 2001-10-02 Luis A. Davila Self-expanding stent-graft
US20010046610A1 (en) * 2000-02-03 2001-11-29 Barnes John J. Metallurgically bonded layered article having a curved surface
US6695865B2 (en) 2000-03-20 2004-02-24 Advanced Bio Prosthetic Surfaces, Ltd. Embolic protection device
US8845713B2 (en) 2000-05-12 2014-09-30 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same
US6652579B1 (en) 2000-06-22 2003-11-25 Advanced Cardiovascular Systems, Inc. Radiopaque stent
US20030077200A1 (en) * 2000-07-07 2003-04-24 Craig Charles H. Enhanced radiopaque alloy stent
US20030018380A1 (en) † 2000-07-07 2003-01-23 Craig Charles H. Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom
GB0020491D0 (en) 2000-08-18 2000-10-11 Angiomed Ag Stent with attached element and method of making such a stent
US6649030B1 (en) 2000-08-31 2003-11-18 Endovascular Technologies, Inc. Physical vapor deposition of radiopaque markings on a graft
US6652574B1 (en) 2000-09-28 2003-11-25 Vascular Concepts Holdings Limited Product and process for manufacturing a wire stent coated with a biocompatible fluoropolymer
US6492615B1 (en) 2000-10-12 2002-12-10 Scimed Life Systems, Inc. Laser polishing of medical devices
US6783793B1 (en) * 2000-10-26 2004-08-31 Advanced Cardiovascular Systems, Inc. Selective coating of medical devices
US6761708B1 (en) * 2000-10-31 2004-07-13 Advanced Cardiovascular Systems, Inc. Radiopaque marker for a catheter and method of making
ATE432673T1 (de) * 2000-10-31 2009-06-15 Boston Scient Ltd Endoluminale vorrichtung mit superelastischen und plastisch verformbaren abschnitten
WO2002038080A2 (en) * 2000-11-07 2002-05-16 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal stent, self-fupporting endoluminal graft and methods of making same
US7314483B2 (en) * 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
CA2428742C (en) * 2000-11-17 2014-07-22 Evysio Medical Devices Ulc Endovascular prosthesis
US7077837B2 (en) * 2000-11-20 2006-07-18 Implant Sciences Corporation Multi-layered radiopaque coating on intravascular devices
US6777110B2 (en) * 2001-01-31 2004-08-17 E. I. Du Pont De Nemours And Company Metallurgically bonded layered article having a curved surface
JP2004518558A (ja) * 2001-01-31 2004-06-24 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 湾曲した表面を有する、冶金的に接合された層状の物品
EP1258230A3 (en) * 2001-03-29 2003-12-10 CardioSafe Ltd Balloon catheter device
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
JP4856829B2 (ja) * 2001-05-24 2012-01-18 川澄化学工業株式会社 バルーンカテーテル及びバルーンの製造方法
US7862495B2 (en) * 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
US6565659B1 (en) * 2001-06-28 2003-05-20 Advanced Cardiovascular Systems, Inc. Stent mounting assembly and a method of using the same to coat a stent
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US20030060872A1 (en) * 2001-09-26 2003-03-27 Gary Gomringer Stent with radiopaque characteristics
US20040116998A1 (en) * 2001-11-19 2004-06-17 Raimund Erbel Endovascular prosthesis
US7147656B2 (en) * 2001-12-03 2006-12-12 Xtent, Inc. Apparatus and methods for delivery of braided prostheses
US7309350B2 (en) * 2001-12-03 2007-12-18 Xtent, Inc. Apparatus and methods for deployment of vascular prostheses
US7351255B2 (en) * 2001-12-03 2008-04-01 Xtent, Inc. Stent delivery apparatus and method
US7270668B2 (en) 2001-12-03 2007-09-18 Xtent, Inc. Apparatus and methods for delivering coiled prostheses
US7182779B2 (en) * 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US20040186551A1 (en) 2003-01-17 2004-09-23 Xtent, Inc. Multiple independent nested stent structures and methods for their preparation and deployment
US7294146B2 (en) * 2001-12-03 2007-11-13 Xtent, Inc. Apparatus and methods for delivery of variable length stents
US20030135266A1 (en) 2001-12-03 2003-07-17 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7137993B2 (en) * 2001-12-03 2006-11-21 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7892273B2 (en) * 2001-12-03 2011-02-22 Xtent, Inc. Custom length stent apparatus
US8080048B2 (en) 2001-12-03 2011-12-20 Xtent, Inc. Stent delivery for bifurcated vessels
US7125464B2 (en) * 2001-12-20 2006-10-24 Boston Scientific Santa Rosa Corp. Method for manufacturing an endovascular graft section
US7326237B2 (en) * 2002-01-08 2008-02-05 Cordis Corporation Supra-renal anchoring prosthesis
US7951258B2 (en) * 2002-03-29 2011-05-31 Lamera Ab Arrangement and methods for the manufacture of composite layer structures
US7637935B2 (en) * 2002-05-06 2009-12-29 Abbott Laboratories Endoprosthesis for controlled contraction and expansion
EP2529707B1 (en) * 2002-05-08 2015-04-15 Abbott Laboratories Endoprosthesis having foot extensions
US6865810B2 (en) * 2002-06-27 2005-03-15 Scimed Life Systems, Inc. Methods of making medical devices
EP1549248A4 (en) * 2002-09-26 2015-11-25 Advanced Bio Prosthetic Surfac NITINOL VACUUM-DEPOSITED ALLOY FILMS HAVING HIGH RESISTANCE, MEDICAL MATERIALS FOR THIN FILM CANDLES, AND METHOD OF MANUFACTURING THE SAME
US6638301B1 (en) * 2002-10-02 2003-10-28 Scimed Life Systems, Inc. Medical device with radiopacity
US7331986B2 (en) * 2002-10-09 2008-02-19 Boston Scientific Scimed, Inc. Intraluminal medical device having improved visibility
US7169178B1 (en) 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US6970734B2 (en) 2002-12-02 2005-11-29 Boston Scientific Scimed, Inc. Flexible marker bands
US20040143317A1 (en) * 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices
JP3966468B2 (ja) * 2003-02-12 2007-08-29 学校法人日本大学 生体組織の弾力特性測定装置
US7399296B2 (en) * 2003-02-26 2008-07-15 Medtronic Vascular, Inc. Catheter having highly radiopaque embedded segment
US7625398B2 (en) * 2003-05-06 2009-12-01 Abbott Laboratories Endoprosthesis having foot extensions
US7625401B2 (en) 2003-05-06 2009-12-01 Abbott Laboratories Endoprosthesis having foot extensions
ATE447904T1 (de) 2003-05-07 2009-11-15 Advanced Bio Prosthetic Surfac Metallische implantierbare prothesen und herstellungsverfahren dafür
US8225481B2 (en) * 2003-05-19 2012-07-24 Pratt & Whitney Rocketdyne, Inc. Diffusion bonded composite material and method therefor
US7241308B2 (en) 2003-06-09 2007-07-10 Xtent, Inc. Stent deployment systems and methods
US7247986B2 (en) * 2003-06-10 2007-07-24 Samsung Sdi. Co., Ltd. Organic electro luminescent display and method for fabricating the same
DE10338338B4 (de) * 2003-08-21 2005-06-30 Elringklinger Ag Schlauch mit einer Markierung und Verfahren zum Herstellen einer Markierung an einem Schlauch
US7198675B2 (en) * 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US7553324B2 (en) * 2003-10-14 2009-06-30 Xtent, Inc. Fixed stent delivery devices and methods
US20050080475A1 (en) * 2003-10-14 2005-04-14 Xtent, Inc. A Delaware Corporation Stent delivery devices and methods
US7192440B2 (en) * 2003-10-15 2007-03-20 Xtent, Inc. Implantable stent delivery devices and methods
WO2005044361A1 (en) * 2003-11-07 2005-05-19 Merlin Md Pte Ltd Implantable medical devices with enhanced visibility, mechanical properties and biocompatibility
US7403966B2 (en) * 2003-12-08 2008-07-22 Freescale Semiconductor, Inc. Hardware for performing an arithmetic function
US20070156225A1 (en) * 2003-12-23 2007-07-05 Xtent, Inc. Automated control mechanisms and methods for custom length stent apparatus
US7326236B2 (en) * 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
US8002822B2 (en) * 2004-01-22 2011-08-23 Isoflux, Inc. Radiopaque coating for biomedical devices
US7243408B2 (en) * 2004-02-09 2007-07-17 Boston Scientific Scimed, Inc. Process method for attaching radio opaque markers to shape memory stent
US7323006B2 (en) * 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
EP1734897A4 (en) 2004-03-31 2010-12-22 Merlin Md Pte Ltd PROCESS FOR TREATING ANEURYSMS
US8500751B2 (en) 2004-03-31 2013-08-06 Merlin Md Pte Ltd Medical device
US8715340B2 (en) * 2004-03-31 2014-05-06 Merlin Md Pte Ltd. Endovascular device with membrane
US20050228477A1 (en) * 2004-04-09 2005-10-13 Xtent, Inc. Topographic coatings and coating methods for medical devices
US20050288481A1 (en) * 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
US7758892B1 (en) * 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US8317859B2 (en) 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US20050288766A1 (en) * 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US20060069424A1 (en) * 2004-09-27 2006-03-30 Xtent, Inc. Self-constrained segmented stents and methods for their deployment
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
WO2006033641A1 (en) * 2004-12-22 2006-03-30 Merlin Md Pte Ltd A medical device
US20060142852A1 (en) * 2004-12-29 2006-06-29 Boston Scientific Scimed, Inc. Low profile, durable, reinforced ePTFE composite graft
US7806922B2 (en) 2004-12-31 2010-10-05 Boston Scientific Scimed, Inc. Sintered ring supported vascular graft
US7857843B2 (en) 2004-12-31 2010-12-28 Boston Scientific Scimed, Inc. Differentially expanded vascular graft
US7524445B2 (en) * 2004-12-31 2009-04-28 Boston Scientific Scimed, Inc. Method for making ePTFE and structure containing such ePTFE, such as a vascular graft
US20060210700A1 (en) * 2005-03-18 2006-09-21 Lachner Thomas F Flexible and plastic radiopaque laminate composition
DE102005013547B4 (de) 2005-03-23 2009-02-05 Admedes Schuessler Gmbh Aneurysmen-Stent und Verfahren zu seiner Herstellung
US20060216431A1 (en) * 2005-03-28 2006-09-28 Kerrigan Cameron K Electrostatic abluminal coating of a stent crimped on a balloon catheter
US7402168B2 (en) * 2005-04-11 2008-07-22 Xtent, Inc. Custom-length stent delivery system with independently operable expansion elements
DE102005019612B4 (de) 2005-04-27 2010-11-25 Admedes Schuessler Gmbh Mechanische Verriegelung eines Röntgenmarkers im Eyelet eines Stents oder in einem anderen Körperimplantat
US20060259126A1 (en) * 2005-05-05 2006-11-16 Jason Lenz Medical devices and methods of making the same
US7938851B2 (en) * 2005-06-08 2011-05-10 Xtent, Inc. Devices and methods for operating and controlling interventional apparatus
US8157851B2 (en) * 2005-06-08 2012-04-17 Xtent, Inc. Apparatus and methods for deployment of multiple custom-length prostheses
EP2364676B1 (en) 2005-06-30 2018-12-19 Abbott Laboratories Endoprosthesis having foot extensions
US20070038176A1 (en) * 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
DE102005039136B4 (de) 2005-08-18 2011-07-28 Admedes Schuessler GmbH, 75179 Verbesserung der Röntgensichtbarkeit und Korrosionsbeständigkeit von NiTi Stents unter Einsatz von Nieten aus Sandwichmaterial
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US8840660B2 (en) * 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070179587A1 (en) * 2006-01-30 2007-08-02 Xtent, Inc. Apparatus and methods for deployment of custom-length prostheses
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
AU2006338324A1 (en) * 2006-02-13 2007-08-23 Merlin Md Pte Ltd Endovascular device with membrane
US8038803B2 (en) 2006-03-07 2011-10-18 Abbott Laboratories Method of descaling metallic devices
US7776189B2 (en) * 2006-03-07 2010-08-17 Abbott Laboratories Method and apparatus for electropolishing metallic stents
JP2009530060A (ja) 2006-03-20 2009-08-27 エックステント・インコーポレーテッド 連結されたプロテーゼセグメントの展開装置及び方法
US20070224235A1 (en) * 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
JP5078271B2 (ja) 2006-03-30 2012-11-21 テルモ株式会社 生体器官拡張用ステントおよびその製造方法
US8048150B2 (en) * 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US7955383B2 (en) * 2006-04-25 2011-06-07 Medtronics Vascular, Inc. Laminated implantable medical device having a metallic coating
US8003156B2 (en) * 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US20070264303A1 (en) * 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
GB0609841D0 (en) 2006-05-17 2006-06-28 Angiomed Ag Bend-capable tubular prosthesis
GB0609911D0 (en) 2006-05-18 2006-06-28 Angiomed Ag Bend-capable stent prosthesis
US20070281117A1 (en) * 2006-06-02 2007-12-06 Xtent, Inc. Use of plasma in formation of biodegradable stent coating
US11039942B2 (en) * 2006-06-13 2021-06-22 Sino Medical Sciences Technology Inc. Drug eluting stent and method of use of the same for enabling restoration of functional endothelial cell layers
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) * 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
CA2655793A1 (en) * 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
JP2009545407A (ja) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド 三次元分解制御を備えたエンドプロテーゼ
GB0616729D0 (en) * 2006-08-23 2006-10-04 Angiomed Ag Method of welding a component to a shape memory alloy workpiece
US20080215132A1 (en) * 2006-08-28 2008-09-04 Cornova, Inc. Implantable devices having textured surfaces and methods of forming the same
GB0616999D0 (en) * 2006-08-29 2006-10-04 Angiomed Ag Annular mesh
US8500793B2 (en) * 2006-09-07 2013-08-06 C. R. Bard, Inc. Helical implant having different ends
US8414637B2 (en) * 2006-09-08 2013-04-09 Boston Scientific Scimed, Inc. Stent
JP2010503469A (ja) 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド 薬物溶出性皮膜を有する医療デバイス
JP2010503489A (ja) * 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生体内分解性内部人工器官およびその製造方法
WO2008034013A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
DE602007011114D1 (de) 2006-09-15 2011-01-20 Boston Scient Scimed Inc Biologisch erodierbare endoprothese mit biostabilen anorganischen schichten
WO2008034066A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
WO2008036548A2 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
WO2008036457A2 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Controlling biodegradation of a medical instrument
WO2008045184A1 (en) * 2006-10-05 2008-04-17 Boston Scientific Limited Polymer-free coatings for medical devices formed by plasma electrolytic deposition
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
GB0622465D0 (en) 2006-11-10 2006-12-20 Angiomed Ag Stent
GB0624419D0 (en) * 2006-12-06 2007-01-17 Angiomed Ag Stenting ring with marker
ES2506144T3 (es) * 2006-12-28 2014-10-13 Boston Scientific Limited Endoprótesis bioerosionables y procedimiento de fabricación de las mismas
US20080199510A1 (en) 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
GB0703379D0 (en) * 2007-02-21 2007-03-28 Angiomed Ag Stent with radiopaque marker
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8486132B2 (en) 2007-03-22 2013-07-16 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
GB0706499D0 (en) 2007-04-03 2007-05-09 Angiomed Ag Bendable stent
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7810223B2 (en) * 2007-05-16 2010-10-12 Boston Scientific Scimed, Inc. Method of attaching radiopaque markers to intraluminal medical devices, and devices formed using the same
US7976915B2 (en) * 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8252361B2 (en) * 2007-06-05 2012-08-28 Abbott Cardiovascular Systems Inc. Implantable medical devices for local and regional treatment
US20080306584A1 (en) * 2007-06-05 2008-12-11 Pamela Kramer-Brown Implantable medical devices for local and regional treatment
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US20090005853A1 (en) * 2007-06-26 2009-01-01 Karim Osman Integration Of Markers Into Bar Arms
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
WO2009012353A2 (en) 2007-07-19 2009-01-22 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) * 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
WO2009018340A2 (en) * 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (ja) * 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
GB0717481D0 (en) 2007-09-07 2007-10-17 Angiomed Ag Self-expansible stent with radiopaque markers
US8052745B2 (en) * 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090076584A1 (en) * 2007-09-19 2009-03-19 Xtent, Inc. Apparatus and methods for deployment of multiple custom-length prostheses
US20090082841A1 (en) * 2007-09-26 2009-03-26 Boston Scientific Corporation Apparatus for securing stent barbs
US8663309B2 (en) * 2007-09-26 2014-03-04 Trivascular, Inc. Asymmetric stent apparatus and method
US8066755B2 (en) * 2007-09-26 2011-11-29 Trivascular, Inc. System and method of pivoted stent deployment
US20090082845A1 (en) * 2007-09-26 2009-03-26 Boston Scientific Corporation Alignment stent apparatus and method
US8226701B2 (en) 2007-09-26 2012-07-24 Trivascular, Inc. Stent and delivery system for deployment thereof
CN101917929A (zh) 2007-10-04 2010-12-15 特里瓦斯库拉尔公司 用于低型面经皮递送的模块化脉管移植物
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118809A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8029554B2 (en) * 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US20090118813A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Nano-patterned implant surfaces
US8328861B2 (en) 2007-11-16 2012-12-11 Trivascular, Inc. Delivery system and method for bifurcated graft
US8083789B2 (en) * 2007-11-16 2011-12-27 Trivascular, Inc. Securement assembly and method for expandable endovascular device
US20090143855A1 (en) * 2007-11-29 2009-06-04 Boston Scientific Scimed, Inc. Medical Device Including Drug-Loaded Fibers
WO2009079389A2 (en) * 2007-12-14 2009-06-25 Boston Scientific Limited Drug-eluting endoprosthesis
US20100331958A1 (en) * 2007-12-20 2010-12-30 Trivascular, Inc. Hinged endovascular device
US8623071B2 (en) * 2008-01-07 2014-01-07 DePuy Synthes Products, LLC Radiopaque super-elastic intravascular stent
US9101503B2 (en) * 2008-03-06 2015-08-11 J.W. Medical Systems Ltd. Apparatus having variable strut length and methods of use
US8252048B2 (en) * 2008-03-19 2012-08-28 Boston Scientific Scimed, Inc. Drug eluting stent and method of making the same
EP2271380B1 (en) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) * 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9962523B2 (en) 2008-06-27 2018-05-08 Merit Medical Systems, Inc. Catheter with radiopaque marker
US20100004733A1 (en) * 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
US7985252B2 (en) * 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
CN103520824A (zh) * 2008-09-05 2014-01-22 C·R·巴德公司 具有不透射线的粘合剂的球囊
US8262692B2 (en) * 2008-09-05 2012-09-11 Merlin Md Pte Ltd Endovascular device
US8821562B2 (en) 2008-09-25 2014-09-02 Advanced Bifurcation Systems, Inc. Partially crimped stent
US8769796B2 (en) 2008-09-25 2014-07-08 Advanced Bifurcation Systems, Inc. Selective stent crimping
US8795347B2 (en) 2008-09-25 2014-08-05 Advanced Bifurcation Systems, Inc. Methods and systems for treating a bifurcation with provisional side branch stenting
CN102215780B (zh) 2008-09-25 2015-10-14 高级分支系统股份有限公司 部分压接支架
US11298252B2 (en) 2008-09-25 2022-04-12 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
US8382824B2 (en) * 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US9427304B2 (en) * 2008-10-27 2016-08-30 St. Jude Medical, Cardiology Division, Inc. Multi-layer device with gap for treating a target site and associated method
US8231980B2 (en) * 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
JP2012511411A (ja) * 2008-12-10 2012-05-24 ボストン サイエンティフィック サイムド，インコーポレイテッド チタン合金部材とスチール合金部材との間に継手を形成する方法および前記継手を含んでなる医療用デバイス
EP2403546A2 (en) * 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) * 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US9492587B2 (en) * 2009-04-13 2016-11-15 Abbott Cardiovascular Systems Inc. Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance
US8287937B2 (en) * 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20100274352A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scrimed, Inc. Endoprosthesis with Selective Drug Coatings
US20110022158A1 (en) * 2009-07-22 2011-01-27 Boston Scientific Scimed, Inc. Bioerodible Medical Implants
WO2011100367A2 (en) * 2010-02-10 2011-08-18 Trivascular, Inc. Fill tube manifold and delivery methods for endovascular graft
US8668732B2 (en) * 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
WO2011119883A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. Stent alignment during treatment of a bifurcation
CA2794080A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. System and methods for treating a bifurcation
US11298251B2 (en) 2010-11-17 2022-04-12 Abbott Cardiovascular Systems, Inc. Radiopaque intraluminal stents comprising cobalt-based alloys with primarily single-phase supersaturated tungsten content
JP2014508559A (ja) 2010-12-30 2014-04-10 ボストン サイエンティフィック サイムド，インコーポレイテッド 多段開放式ステント設計
EP2672932B1 (en) 2011-02-08 2018-09-19 Advanced Bifurcation Systems, Inc. System for treating a bifurcation with a fully crimped stent
WO2012109382A2 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use
US8790388B2 (en) 2011-03-03 2014-07-29 Boston Scientific Scimed, Inc. Stent with reduced profile
WO2012118526A1 (en) 2011-03-03 2012-09-07 Boston Scientific Scimed, Inc. Low strain high strength stent
US20120316633A1 (en) * 2011-06-07 2012-12-13 Boston Scientific Scimed, Inc. Durable Stent Drug Eluting Coating
US9724494B2 (en) 2011-06-29 2017-08-08 Abbott Cardiovascular Systems, Inc. Guide wire device including a solderable linear elastic nickel-titanium distal end section and methods of preparation therefor
US8992595B2 (en) 2012-04-04 2015-03-31 Trivascular, Inc. Durable stent graft with tapered struts and stable delivery methods and devices
US9498363B2 (en) 2012-04-06 2016-11-22 Trivascular, Inc. Delivery catheter for endovascular device
ES2943709T3 (es) 2012-04-06 2023-06-15 Merlin Md Pte Ltd Dispositivos para tratar un aneurisma
EP2656944B1 (de) * 2012-04-23 2018-03-21 Biotronik AG Verfahren zur Herstellung eines Implantats
WO2013162690A1 (en) 2012-04-26 2013-10-31 Medtronic Vascular Inc. Radiopaque enhanced cobalt alloy for stents
US9339398B2 (en) 2012-04-26 2016-05-17 Medtronic Vascular, Inc. Radiopaque enhanced nickel alloy for stents
US10130900B2 (en) 2016-06-16 2018-11-20 Bandera Acquisition, Llc Composite column for use in high pressure liquid chromatography
CN107790970B (zh) * 2017-10-20 2019-08-06 嘉峪关天源新材料有限责任公司 一种铜钢复合管及其制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2836181A (en) * 1955-01-17 1958-05-27 Chemstrand Corp Flexible nylon tube and method for preparing same
US3155095A (en) * 1961-02-07 1964-11-03 Adolph M Brown Anastomosis method and means
AT261800B (de) * 1966-08-22 1968-05-10 Braun Internat Gmbh B Verfahren zur Herstellung von röhrenförmigen, glatten bzw. mit einem Gewinde versehenen Gewebe-Blutgefäß-Prothesen
US3585647A (en) * 1968-04-25 1971-06-22 Baxter Laboratories Inc Antithrombogenic article and process
US4604762A (en) * 1981-02-13 1986-08-12 Thoratec Laboratories Corporation Arterial graft prosthesis
CA1204643A (en) * 1981-09-16 1986-05-20 Hans I. Wallsten Device for application in blood vessels or other difficulty accessible locations and its use
US4542539A (en) * 1982-03-12 1985-09-24 Artech Corp. Surgical implant having a graded porous coating
US4834755A (en) * 1983-04-04 1989-05-30 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
SE450809B (sv) * 1985-04-10 1987-08-03 Medinvent Sa Plant emne avsett for tillverkning av en spiralfjeder lemplig for transluminal implantation samt derav tillverkad spiralfjeder
US5628781A (en) * 1985-06-06 1997-05-13 Thomas Jefferson University Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4878906A (en) * 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US4793348A (en) * 1986-11-15 1988-12-27 Palmaz Julio C Balloon expandable vena cava filter to prevent migration of lower extremity venous clots into the pulmonary circulation
JPS63238872A (ja) * 1987-03-25 1988-10-04 テルモ株式会社 管状器官内腔の内径確保用器具
US5059211A (en) * 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5192307A (en) * 1987-12-08 1993-03-09 Wall W Henry Angioplasty stent
US4981478A (en) * 1988-09-06 1991-01-01 Advanced Cardiovascular Systems Composite vascular catheter
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US4917666A (en) * 1988-11-14 1990-04-17 Medtronic Versaflex, Inc. Steerable thru-lumen catheter
US5163958A (en) * 1989-02-02 1992-11-17 Cordis Corporation Carbon coated tubular endoprosthesis
US5425739A (en) * 1989-03-09 1995-06-20 Avatar Design And Development, Inc. Anastomosis stent and stent selection system
US4994071A (en) * 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5071407A (en) * 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
DE4104702C2 (de) * 1991-02-15 1996-01-18 Malte Neuss Implantate für Organwege in Wendelform
US5197978B1 (en) * 1991-04-26 1996-05-28 Advanced Coronary Tech Removable heat-recoverable tissue supporting device
US5527354A (en) * 1991-06-28 1996-06-18 Cook Incorporated Stent formed of half-round wire
US5356433A (en) * 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
US5443498A (en) * 1991-10-01 1995-08-22 Cook Incorporated Vascular stent and method of making and implanting a vacsular stent
US5234457A (en) * 1991-10-09 1993-08-10 Boston Scientific Corporation Impregnated stent
US5662713A (en) * 1991-10-09 1997-09-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
CA2079417C (en) * 1991-10-28 2003-01-07 Lilip Lau Expandable stents and method of making same
US5372600A (en) * 1991-10-31 1994-12-13 Instent Inc. Stent delivery systems
US5316023A (en) * 1992-01-08 1994-05-31 Expandable Grafts Partnership Method for bilateral intra-aortic bypass
US5507767A (en) * 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
CA2087132A1 (en) * 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
US5282823A (en) * 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
DE4240177C2 (de) * 1992-11-30 1997-02-13 Ruesch Willy Ag Selbstexpandierender Stent für Hohlorgane
US5342348A (en) * 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5419760A (en) * 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5423849A (en) * 1993-01-15 1995-06-13 Target Therapeutics, Inc. Vasoocclusion device containing radiopaque fibers
US5630840A (en) * 1993-01-19 1997-05-20 Schneider (Usa) Inc Clad composite stent
ES2166370T3 (es) * 1993-01-19 2002-04-16 Schneider Usa Inc Filamento implantable en material compuesto.
US5480423A (en) * 1993-05-20 1996-01-02 Boston Scientific Corporation Prosthesis delivery
US5441516A (en) * 1994-03-03 1995-08-15 Scimed Lifesystems Inc. Temporary stent
US5449373A (en) * 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
US5540701A (en) * 1994-05-20 1996-07-30 Hugh Sharkey Passive fixation anastomosis method and device
US5476508A (en) * 1994-05-26 1995-12-19 Tfx Medical Stent with mutually interlocking filaments
EP1051953A3 (en) * 1994-06-17 2001-02-28 Terumo Kabushiki Kaisha Indwelling stent and the method for manufacturing the same
US5545210A (en) * 1994-09-22 1996-08-13 Advanced Coronary Technology, Inc. Method of implanting a permanent shape memory alloy stent
US5637113A (en) * 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5667523A (en) * 1995-04-28 1997-09-16 Impra, Inc. Dual supported intraluminal graft
US5551444A (en) * 1995-05-31 1996-09-03 Radius Medical Technologies, Inc. Flexible guidewire with radiopaque outer coil and non-radiopaque inner coil

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100436119C (zh) * 2000-02-03 2008-11-26 纳幕尔杜邦公司 冶金结合的具有弯曲表面的层状制品
CN102429750A (zh) * 2011-08-15 2012-05-02 微创医疗器械(上海)有限公司 改进显影性能的血管支架及增强血管支架显影性能的方法
WO2013023583A1 (zh) * 2011-08-15 2013-02-21 上海微创医疗器械（集团）有限公司 改进显影性能的血管支架及增强血管支架显影性能的方法
CN107184291A (zh) * 2011-10-07 2017-09-22 W.L.戈尔及同仁股份有限公司 可刺穿又可再密封的移植物
CN107184291B (zh) * 2011-10-07 2019-11-05 W.L.戈尔及同仁股份有限公司 可刺穿又可再密封的移植物
CN104454415A (zh) * 2014-12-10 2015-03-25 北京航空航天大学 一种闸线式形状记忆合金驱动器
CN104454415B (zh) * 2014-12-10 2018-10-23 北京航空航天大学 一种闸线式形状记忆合金驱动器
CN106937894A (zh) * 2017-03-16 2017-07-11 贵州医科大学附属医院 增强血管支架显影性能的显影标志、血管支架和方法
CN107361880A (zh) * 2017-06-20 2017-11-21 西安交通大学 一种仿生颈动脉血管的制备方法
CN108325047A (zh) * 2018-03-26 2018-07-27 青岛市中心医院 一种体外导向心导管装置
CN108723711A (zh) * 2018-05-24 2018-11-02 上海天阳钢管有限公司 一种制造复合油井管的工艺方法
CN108747214A (zh) * 2018-05-24 2018-11-06 上海天阳钢管有限公司 一种制造带节箍的复合油井管的工艺方法

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ES2252799T3 (es) 2006-05-16
DK1011527T3 (da) 2006-04-10
EP1011527A1 (en) 2000-06-28
IL130918A0 (en) 2001-01-28
US5858556A (en) 1999-01-12
AU7998498A (en) 1998-08-07
EP1011527B1 (en) 2005-11-30
WO1998031304A1 (en) 1998-07-23
AR011062A1 (es) 2000-08-02
EP1011527A4 (en) 2002-05-08
CN1173674C (zh) 2004-11-03
IL130918A (en) 2004-06-20
CA2277841C (en) 2007-04-24
AU733023B2 (en) 2001-05-03
TW362023B (en) 1999-06-21
JP2000515052A (ja) 2000-11-14
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CA2277841A1 (en) 1998-07-23
BR9714324A (pt) 2000-02-08

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