CN105289385A - Distorted arc-shaped micro mixer based on enhanced secondary flow effect - Google Patents
Distorted arc-shaped micro mixer based on enhanced secondary flow effect Download PDFInfo
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Abstract
The invention provides a distorted arc-shaped micro mixer based on an enhanced secondary flow effect. The micro mixer comprises a plurality of inlets, a mixing pipeline, an arc-shaped bend hybrid matrix and an outlet, wherein the inlets are communicated with one end of the arc-shaped bend hybrid matrix through the mixing pipeline, the other end of the arc-shaped bend hybrid matrix is communicated with the outlet, and the arc-shaped bend hybrid matrix comprises a plurality of arc-shaped bend mixing units which are sequentially communicated. Compared with a common S-type mixing pipeline, the mixing speed of the mixer is increased in a nonlinear mode along with mixing length increase.
Description
Technical field
The present invention relates to micro-mixer chip, particularly, relating to a kind of distortion arc micro-mixer based on strengthening secondary flow patterns effect.
Background technology
Micro-mixer is the equipment for the low capacity fluid of mixed flow in very narrow passage.Object is that in the many microfluidics systems for biochemical analysis, drug delivery and nucleic acid series or synthesis, micro-mixer is necessary.The bioprocess such as such as cell activation, enzyme reaction and protein folding often relate to the reaction requiring to start with mixed reactant.In the chemical system that the multiple microcosmic carrying out complicated chemical synthesis manufactures, mixing is also necessary.See " PassiveMixinginaThree-DimensionalSerpentineMicrochannel, " R.H.Liu, M.A.Stremler, K.V.Sharp, JournalofMicroelectromechanicalSystem, Vol.9, No.1, June2000.
With the fluid-phase ratio flowed in macrocosm, when fluid flows in the passage being similar to human hair's size, be called that the phenomenon of laminar flow presents very different character.Laminar flow is also relevant to low reynolds number (Reynoldsnumber), and this laminar flow makes the different layers of the fluid in the channel when mixing a little or do not have to mix or mutually adjacent particle move (except diffusion).
As the people such as Liu utilize classification explained, adopt this classification in this article, microcosmic blender can be divided into initiatively or passive mixer.Passive stirring scheme comprises layering in simple face and chaotic advection stirs (rapid deformation and elongation that the people such as Liu is defined as material interface).Active mixer has the parts of movement or the outside forcing function applied, such as pressure, electric field or ultrasonic wave.Passive mixer utilizes the geometry of passage usually, increases the interfacial area between fluid to be mixed, or the chaos effect of enhance fluid, thus improves the possibility of diffusion mixing.These blenders can be divided into two kinds of groups: in face outside blender and face or lamination mixers, in face, blender separates and mixes logistics in the fluid network being limited in a plane, outside face or lamination mixers utilize three-dimensional channel geometry.Passive mixer outside the face that the paper of the people such as the above-mentioned Liu quoted describes three dimensional tortuous channel, this blender depends on chaotic advection, and blender in two faces: square-wave channel and beeline channel.In the simplest face, two liquid stream are merged in single passage by blender, by means of molecular diffusion, depend on that time and high diffusivity coefficient realize mixing, thus fluid-mixing or move solute between the fluids.Concerning the Biosample forming the normally complicated oligomeric or paradigmatic structure of molecule, this is difficult.Outside face, lamination mixers separately liquid stream liquid stream is deposited in threedimensional fluidic network continuously.Lamination mixers requires multilayer microfabrication techniques usually, this make they concerning target be simple manufacture, planar design and be easily integrated into microfluidics systems bioanalysis system designers, not attractive.
Recently developed multiple microfluid mixing apparatus, these fluid devices are attempted to improve the mixing of microscale devices inner fluid.United States Patent (USP) 6 that on October 24th, 2000 promulgates, that transfer UniversityofWashington, 136,272 to describe in microfluidic channels and connect fast and the device of separate fluid layer, and this allows in both direction (depth direction and width), carry out diffusion and mixes.Unfortunately, the device described in this patent relates to the bending bridge channels (curvedbridgechannel) used in " mixed mode ", this device is not described in the centrifugal mixing in these passages, in fact shows the Laminar Flow be devoted to separation and remains in bridge channels.The unique mixture table occurred in these devices reveals and is present in parallel straight channel, and parallel straight channel is positioned at the downstream of any bridge channels.
Strengthening Secondary Flow effect is that a kind of mixing efficiency that improves compares effective method, and when fluid is through arc bend, because the pressure on same cross section is different with flow velocity, can produce the Secondary Flow on cross section, this Secondary Flow can effectively strengthen liquid mixability.The present invention is exactly based on Secondary Flow effect, designs bend as much as possible and forms Secondary Flow and improve mixing efficiency.
Although micro-mixer has in recent years had considerable progress, in multiple field, still there are unsatisfied needs, be not enough to effective in microfluidic device, reliable and repeatedly can mix one or more actual and samples.Such as, the bioprocess such as biochemical analysis, drug delivery and nucleic acid series or synthesis, such as cell activation, enzyme reaction and protein folding is usually directed to require that mixed reactant is with the reaction started in micro-space.In the chemical system that the multiple microcosmic carrying out complicated chemical synthesis (such as combinatorial chemistry) manufactures, mixing is also necessary.Except the requirement meeting biochemical reaction, how to utilize simple as far as possible technique to prepare the effective way that efficient micro-mixer is also extended hybrid device range of application, existing most of micro-mixer can not meet above requirement completely.
Along with microelectromechanical systems (Micro-Electro-MechanicalSystems, MEMS) fast development of technology and the subject such as life science, analysis science, Bio-MEMS (Bio-MEMS) technology and progressively become the study hotspot of people based on the micro-total analysis system (MicroTotalAnalysisSystem, μ TAS) of Bio-MEMS technology.The present invention is prepared from based on MEMS technology.
Summary of the invention
For defect of the prior art, the object of this invention is to provide a kind of distortion arc micro-mixer based on strengthening secondary flow patterns effect.
According to the distortion arc micro-mixer based on strengthening secondary flow patterns effect provided by the invention, comprise multiple import, mixing duct, arc bend hybrid matrix and outlet;
Wherein, described multiple import is communicated with one end of described arc bend hybrid matrix by described mixing duct; The other end of described arc bend hybrid matrix is communicated with described outlet;
Described arc bend hybrid matrix comprises multiple arc bend mixed cell be communicated with successively.
Preferably, described arc bend mixed cell comprises the first curved channel, the second curved channel, the 3rd curved channel and the 4th curved channel;
Wherein, described first curved channel, described second curved channel, described 3rd curved channel are connected successively with described 4th curved channel;
Multiple described arc bend mixed cell is connected successively and forms arc bend mixing array, in wherein adjacent two described arc bend mixed cells, arc bend mixed cell described in two connects the first curved channel or the 4th curved channel of another arc bend mixed cell in two;
Multiple described arc bend mixing array is connected successively and forms arc bend hybrid matrix, in two wherein adjacent arc bend mixing array, the arc bend mixing array in two connects one end or the other end of another arc bend mixing array in two.
Preferably, described first curved channel, described second curved channel and described 3rd curved channel are semicircular arc; Described 4th curved channel is 1/4 circular arc;
The radius of curvature of described first curved channel and described 4th curved channel is 0.15mm to 1mm; The radius of curvature of described second curved channel and described 3rd curved channel is 0.05mm to 0.3mm.
Preferably, described multiple import, described mixing duct, described arc bend mixing array and described outlet are made by dimethyl silicone polymer casting matrix is bonded in described substrate of glass.
Preferably, described dimethyl silicone polymer casting matrix is made by casting template;
Described casting template is adopted and is made with the following method:
-on silicon chip, spin coating negative photoresist carries out drying and processing, and exposed through the mask plate with figure by litho machine, develop graphically, on silicon chip, form the casting template with runner;
Described dimethyl silicone polymer casting matrix is adopted and is made with the following method:
-by casting in described casting template after dimethyl siloxane performed polymer and curing agent mixing, take out after several hours of isothermal holding, take casting matrix off, and cut into described dimethyl silicone polymer casting matrix.
Preferably, the arc bend that described arc mixing bend unit comprises multiple different curvature radius is connected in turn and forms.
Preferably, described mixing duct is width 20 μm to 150 μm, is highly the rectangular duct of 20 μm to 50 μm.
Preferably, described import and described outlet are cylindrical cavity structure, and described cylindrical cavity diameter of movement is 0.5 to 2mm.
Preferably, multiple described arc mixing bend unit according to first left distortion again the principle of right distortion be connected and form arc bend mixing array;
Multiple described arc bend mixing array according to first left distortion again the principle of right distortion be connected and form arc bend hybrid matrix.
Compared with prior art, the present invention has following beneficial effect:
1, mixing velocity is fast, and the present invention is compared with comparatively conventional S type mixing duct, and the mixing velocity of this blender is non-linear growth along with mixing length increases;
2, utilization rate is high, and general blender mixing rate and chip utilization rate cannot have concurrently, and require that mixing rate then needs complicated mixed structure and larger chip area, chip area is little, cannot improve mixing rate.The chip area utilization rate that the present invention increases while improving mixing rate, i.e. the area utilization of dimethyl silicone polymer casting matrix;
3, highly versatile, micro-mixer is owing to being limited to preparation technology and material, and mostly cannot meet the mix reagent of various character, particularly large biological molecule is as protein, nucleic acid etc., and this present invention only uses the PDMS of inertia and glass as passage construction material, spectrum usability is higher;
4, preparation technology is simple, and the present invention and other micro-fluidic chip processing compatibilities by force, have considered MEMS preparation technology in design, accomplished the compatibility of chip preparing process, and manufacture craft is simple, is easy to mass production.
Accompanying drawing explanation
By reading the detailed description done non-limiting example with reference to the following drawings, other features, objects and advantages of the present invention will become more obvious:
Fig. 1 is structural representation of the present invention;
Fig. 2 is cross sectional representation of the present invention;
Fig. 3 is the structural representation of arc bend mixed cell in the present invention;
In figure:
1 is import;
2 is mixing duct;
3 is arc bend mixed cell;
4 is arc bend mixing array;
5 is outlet;
6 is substrate of glass;
7 is dimethyl silicone polymer casting matrix.
8 is hybrid channel.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art and understand the present invention further, but not limit the present invention in any form.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, some distortion and improvement can also be made.These all belong to protection scope of the present invention.
In the present embodiment, the distortion arc micro-mixer based on strengthening secondary flow patterns effect provided by the invention, comprises multiple import 1, mixing duct 2, arc bend hybrid matrix and outlet 5; Wherein, described multiple import 1 is communicated with one end of described arc bend mixing array 4 by described mixing duct 2; The other end of described arc bend hybrid matrix is communicated with described outlet 5; Described arc bend hybrid matrix comprises multiple arc bend mixed cell 3 be communicated with successively.In the present embodiment, the quantity of described import 1 is 2.
The arc bend that described arc mixing bend unit 3 comprises multiple different curvature radius is connected in turn and forms.Be specially, as shown in Figure 3, wherein R
1for inner ring hybrid channel, R
1the semi arch of to be radius of curvature be 0.05 to 0.3mm, R
2semi arch or 1/4 circular arc of to be radius of curvature be 0.15 to 1mm.Multiple described arc mixing bend unit 3 according to first left distortion again the principle of right distortion be connected and form arc bend mixing array; Multiple described arc bend mixing array 4 according to first left distortion again the principle of right distortion be connected and form arc bend hybrid matrix.
In variation, described arc bend mixed cell 3 comprises the first curved channel, the second curved channel, the 3rd curved channel and the 4th curved channel; Wherein, described first curved channel, described second curved channel, described 3rd curved channel are connected successively with described 4th curved channel; Multiple described arc bend mixed cell 3 is connected successively and forms arc bend mixing array 4, in wherein adjacent two described arc bend mixed cells 3, arc bend mixed cell 3 described in two connects the first curved channel or the 4th curved channel of another arc bend mixed cell 3 in two; Multiple described arc bend mixing array 4 is connected successively and forms arc bend hybrid matrix, in two wherein adjacent arc bend mixing array 4, the arc bend mixing array 4 in two connects one end or the other end of another arc bend mixing array 4 in two.Described first curved channel, described second curved channel and described 3rd curved channel are semicircular arc; Described 4th curved channel is 1/4 circular arc; The radius of curvature of described first curved channel and described 4th curved channel is 0.15mm to 1mm; The radius of curvature of described second curved channel and described 3rd curved channel is 0.05mm to 0.3mm.Described first curved channel, the second curved channel, the 3rd curved channel and the 4th curved channel are hybrid channel.Described multiple import 1, described mixing duct 2, described arc bend mixing array 4 and described outlet 5 are made by dimethyl silicone polymer casting matrix 7 is bonded in described substrate of glass 6.Substrate of glass 6 and dimethyl silicone polymer casting matrix 7 utilize oxygen plasma bonding techniques to carry out two-part encapsulation.Described dimethyl silicone polymer casting matrix 7 is made by casting template; Described casting template utilizes the technique of microelectromechanical systems (MEMS) to be prepared from, and specifically adopts and makes with the following method:
-on silicon chip, spin coating negative photoresist carries out drying and processing, and exposed through the mask plate with figure by litho machine, develop graphically, on silicon chip, form the casting template with runner;
Described dimethyl silicone polymer casting matrix 2 is adopted and is made with the following method:
-by casting in described casting template after dimethyl siloxane performed polymer and curing agent mixing, take out after several hours of isothermal holding, take casting matrix off, and cut into described dimethyl silicone polymer casting matrix 7.
In the present embodiment, be incubated 60 DEG C and take out after 2 hours, take dimethyl silicone polymer casting matrix 7 off, and cut into certain size.Last and substrate of glass 6 carries out oxygen plasma bonding.
The arc bend that described arc mixing bend unit 3 comprises multiple different curvature radius is connected in turn and forms.Multiple described arc mixing bend unit 3 according to first left distortion again the principle of right distortion be connected and form arc bend mixing array; Multiple described arc bend mixing array 4 according to first left distortion again the principle of right distortion be connected and form arc bend hybrid matrix.Described mixing duct 2 is width 20 μm to 150 μm, is highly the rectangular duct of 20 μm to 50 μm.Described import and described outlet are cylindrical cavity structure, and described cylindrical cavity diameter of movement is 0.5 to 2mm.
The mixing implementation process of the distortion arc micro-mixer based on strengthening secondary flow patterns effect provided by the invention is: two kinds of liquid to be mixed inject from entrance respectively, in the process of mixing bend flowing through arc bend hybrid matrix, because fluid flows in bend, flow direction changes at any time, produce the Secondary Flow along bend transverse direction when there is sharply change in direction, make two kinds of liquid blendings.Greatly, Secondary Flow is more obvious, and mixing efficiency is also higher, flows out after mixing from outlet 5 in the bend radius of curvature change flowed through.
Above specific embodiments of the invention are described.It is to be appreciated that the present invention is not limited to above-mentioned particular implementation, those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (9)
1., based on the distortion arc micro-mixer strengthening secondary flow patterns effect, it is characterized in that, comprise multiple import (1), mixing duct (2), arc bend hybrid matrix and outlet (5);
Wherein, described multiple import (1) is communicated with one end of described arc bend hybrid matrix (4) by described mixing duct (2); The other end of described arc bend hybrid matrix is communicated with described outlet (5);
Described arc bend hybrid matrix comprises multiple arc bend mixed cell (3) be communicated with successively.
2. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 1, it is characterized in that, described arc bend mixed cell (3) comprises the first curved channel, the second curved channel, the 3rd curved channel and the 4th curved channel;
Wherein, described first curved channel, described second curved channel, described 3rd curved channel are connected successively with described 4th curved channel;
Multiple described arc bend mixed cell (3) is connected successively and forms arc bend mixing array (4), in wherein adjacent two described arc bend mixed cells (3), the first curved channel of another arc bend mixed cell (3) during arc bend mixed cell (3) described in two connects two or the 4th curved channel;
Multiple described arc bend mixing array (4) is connected successively and forms arc bend hybrid matrix, in two wherein adjacent arc bend mixing array (4), one end of another arc bend mixing array (4) during the arc bend mixing array (4) in two connects two or the other end.
3. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 2, is characterized in that,
Described first curved channel, described second curved channel and described 3rd curved channel are semicircular arc; Described 4th curved channel is 1/4 circular arc;
The radius of curvature of described first curved channel and described 4th curved channel is 0.15mm to 1mm; The radius of curvature of described second curved channel and described 3rd curved channel is 0.05mm to 0.3mm.
4. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 1, it is characterized in that, described multiple import (1), described mixing duct (2), described arc bend mixing array (4) and described outlet (5) are made by dimethyl silicone polymer casting matrix (7) is bonded in described substrate of glass (6).
5. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 4, is characterized in that, described dimethyl silicone polymer casting matrix (7) is made by casting template;
Described casting template is adopted and is made with the following method:
-on silicon chip, spin coating negative photoresist carries out drying and processing, and exposed through the mask plate with figure by litho machine, develop graphically, on silicon chip, form the casting template with runner;
Described dimethyl silicone polymer casting matrix (7) is adopted and is made with the following method:
-cast in after dimethyl siloxane performed polymer and curing agent mixing in described casting template, if isothermal holding took out after individual hour, take casting matrix off, and cut into described dimethyl silicone polymer casting matrix (7).
6. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 1, is characterized in that, described arc mixing bend unit (3) comprises that the arc bend of multiple different curvature radius is connected in turn to be formed.
7. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 1, it is characterized in that, described mixing duct (2) is width 20 μm to 150 μm, is highly the rectangular duct of 20 μm to 50 μm.
8. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 1, it is characterized in that, described import and described outlet are cylindrical cavity structure, and described cylindrical cavity diameter of movement is 0.5mm to 2mm.
9. the distortion arc micro-mixer based on strengthening secondary flow patterns effect according to claim 1, it is characterized in that, multiple described arc mixing bend unit (3) according to first left distortion again the principle of right distortion be connected and form arc bend mixing array;
Multiple described arc bend mixing array (4) according to first left distortion again the principle of right distortion be connected and form arc bend hybrid matrix.
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| CN105771763A (en) * | 2016-03-07 | 2016-07-20 | 东南大学 | High concentration gradient microfluidic mixing chip with jet flow damaging function |
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| CN107233833A (en) * | 2017-06-14 | 2017-10-10 | 东南大学 | Ultrafast microfluidic mixer device with viscosity adaptability |
| CN107670520A (en) * | 2017-11-20 | 2018-02-09 | 浙江大学 | The passive mixing device of knot type |
| CN110191590A (en) * | 2019-05-30 | 2019-08-30 | 上海彰恒信息科技有限公司 | A kind of flexible circuit plate preparation method and flexible circuit plate |
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| CN110191590A (en) * | 2019-05-30 | 2019-08-30 | 上海彰恒信息科技有限公司 | A kind of flexible circuit plate preparation method and flexible circuit plate |
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Application publication date: 20160203 |