CN105213267A - A kind of preparation method of microcapsule-type anti-wrinkle eye cream - Google Patents
A kind of preparation method of microcapsule-type anti-wrinkle eye cream Download PDFInfo
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Abstract
The present invention discloses a kind of preparation method of microcapsule-type anti-wrinkle eye cream, with sodium alginate, Carboxymethyl cellulose sodium, hyaluronic acid, mink oil, squalane, lecithin, Jojoba wax, glycerol, serine, corn porous starch, Semen Granati ethanol extract, ganoderol extract, Flos Matricariae chamomillae ethanol extract, coenzyme Q10 and span 20 for raw material, prepare capsule wall solution A, capsule-core mixture B respectively, and after A and B is mixed, first dispersed with stirring carries out homogenizing again, finally homogenizing fluid C is instilled in calcium chloride solution, wash after filtration, obtained.The present invention adopts corn porous starch, lubricant component in core materials and active component are adsorbed, and then make microcapsule-type anti-wrinkle eye cream of the present invention in use, can make to be adsorbed on active component in corn porous starch and oils and fats slowly evenly discharges, and can not discharge in a large number the short time and bring too much nutrition and oil content to skin, and then can not cause the generation of fat granule, and the present invention also has the feature of good penetrability.
Description
Technical field
The invention belongs to microcapsule technology field, be specifically related to a kind of preparation method of microcapsule-type anti-wrinkle eye cream.
Background technology
Eye skin is the thinnest skin of human body, is again activity position the most frequently simultaneously, but also is pull the maximum place of skin number of times in making up, and is very easy to grow wrinkle.The FAQs of eye has following several: black eye, eye pouch, edema, microgroove, dry stricture of vagina, crows-feet, fat granule, eyes lack expression etc., and these eye problems, once occur, are easy to make people seem aged without god.Eye cream is one of skin type product, and it can moisten eye part skin, alleviates the generation of wrinkle, microgroove, effectively prevents the generation of black eye, eye pouch problem, totally plays the effect alleviating eye part skin aging.Based on above-mentioned effect of eye cream, the personage that more and more likes to be beautiful using eye cream as one of daily indispensable skin care item.
If but the eye cream used is improper, also can bring certain harmful effect to eye skin.As most higher containing lubricant component in existing eye cream, contained neutraceutical active ingredients discharges too fast and is not easily absorbed, these oils and fatss or nutritional labeling are deposited on eye part skin, be easy to the generation causing fat granule for a long time in the past, fat granule, once produce elimination in the very difficult short time, can not be despised on the impact that eye part skin causes; If but the eye cream using quality comparatively frivolous, the moist degree of eye cream can be made again to decline, do not reach good maintenance effect.Moreover; the active substance adopted in existing eye cream is most not through certain protection, and directly contacts with external environment, along with the prolongation of time; these active substances be easy to be oxidized by the external world, photodissociation and lose the activity that should possess, and then cause product failure.
Summary of the invention
For prior art above shortcomings, technical problem to be solved by this invention is: the preparation method how providing a kind of microcapsule-type anti-wrinkle eye cream, the product Middle nutrition active component making the method obtained evenly can discharge in use and be easy to absorb, have nourish effective, can not cause that fat granule produces, active substance is not easily by feature that external environment is destroyed.
In order to solve the problems of the technologies described above, the present invention adopts following technical scheme: a kind of preparation method of microcapsule-type anti-wrinkle eye cream, comprises the steps:
1) material of following parts by weight is taken: 40 ~ 50 parts of sodium alginates, 10 ~ 15 parts of Carboxymethyl cellulose sodium, 6 ~ 8 parts of hyaluronic acids, 15 ~ 20 parts of mink oils, 8 ~ 12 parts of squalanes, 6 ~ 9 parts of lecithin, 4 ~ 10 parts of Jojoba waxes, 6 ~ 8 parts of glycerol, 3 ~ 6 parts of serines, 6 ~ 8 parts of corn porous starch, 2 ~ 3 parts of Semen Granati ethanol extract, 1 ~ 3 part of ganoderol extract, 2 ~ 3 parts of Flos Matricariae chamomillae ethanol extract, 1 ~ 2 part of coenzyme Q10 and 4 ~ 7 parts of span 20s;
2) add in deionized water by the sodium alginate taken, Carboxymethyl cellulose sodium and hyaluronic acid, at 70 ~ 80 DEG C, heating for dissolving 5 ~ 10min, obtains capsule wall solution A; Wherein, the deionized water volume added is 30 ~ 40 times of sodium alginate, Carboxymethyl cellulose sodium and hyaluronic acid gross mass;
3) mink oil, squalane, lecithin, Jojoba wax, glycerol, serine, corn porous starch, Semen Granati ethanol extract, ganoderol extract, Flos Matricariae chamomillae ethanol extract, coenzyme Q10 and the span 20 mix homogeneously that will take, under 70 ~ 80 DEG C of water bath condition, stir 0.5 ~ 1h, obtain capsule-core mixture B; The mixing speed of wherein said stirring is 120 ~ 160r/min;
4) mixed by capsule wall solution A and capsule-core mixture B, after blender dispersion 20 ~ 30min, homogenizing 5 ~ 10min, obtains homogenizing fluid C; Wherein, the rotating speed of described blender is 300 ~ 350r/min, and the homogenization pressure of described homogenizing is 35 ~ 50MPa;
5) homogenizing fluid C is heated to 70 ~ 80 DEG C, using glue head dropper that the homogenizing fluid C after heating is slowly added dropwise to mass concentration is in the calcium chloride solution of 5 ~ 7%;
6) calcium chloride solution after step 5) instillation homogenizing fluid C is filtered, discard filtrate, collect oversize;
7) to the oversize deionized water wash 2 ~ 3 times that step 6) is collected, the anti-wrinkle eye cream of described microcapsule-type is obtained.
Compared to existing technology, the present invention has following beneficial effect:
1, the present invention adopts corn porous starch to adsorb the lubricant component in core materials and active component, and then the microcapsule-type anti-wrinkle eye cream making the present invention prepare in use, can make to be adsorbed on active component in corn porous starch and oils and fats slowly evenly discharges, and can not discharge in a large number the short time and bring too much nutrition and oil content to skin, and then the generation of fat granule can not be caused.
2, in order to strengthen the permeability of microcapsule-type anti-wrinkle eye cream prepared by the present invention, the present invention is special by a large amount of experimental studies, choose mink oil, squalane, Jojoba wax is as core materials, and the collaborative compatibility relationship that further study between three, final discovery is when using " 15 ~ 20 parts of mink oils, 8 ~ 12 parts of squalanes and 4 ~ 10 parts of Jojoba waxes " time, the moist degree of this product can either be ensured, again can not be too greasy, and what is more important is when three plays collaborative compatibility effect with this ratio, the permeability of this product can be strengthened, and then enable skin fully absorb nutritional labeling, import respond well.
3, the present invention adopts microcapsule technology, neutraceutical active ingredients embedding is got up, makes this product in use, can not the impact that in external environment, light, heat, oxygen etc. are too much be subject to, effectively ensure that the activity of active substance is not destroyed, the effect extending product keeps the phase.
4, the present invention adopts active skull cap components as nutrient, and this several natural materials is carried out composite, make them farthest play collaborative compatibility effect, the preparation method of giving microcapsule-type anti-wrinkle eye cream of the present invention combines effect with crease-resistant, moisturizing, antioxidative.
5, cyst wall hydrogel material of the present invention brings certain water moisture feeling to this product, and hyaluronic interpolation further increases the performance of keeping humidity of product, make this product in use, it is easier that eye part skin is pushed open, only need massage gently with finger and get final product uniform application, use convenient, the overnutrition at this position will be made to cause fat granule because product is deposited in a certain position of eye part skin.
6, shape of product of the present invention is regular, cyst wall has uniform thickness, and has uniform intensity, can retain the perfect shape of microcapsule and not be destroyed, the problem that capsule-core is revealed can not be caused, can not be damaged during effectively ensureing product stock, transport, shelf life.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, in the present embodiment if no special instructions, raw materials used be commercially available.
Described Semen Granati ethanol extract, ganoderol extract, Flos Matricariae chamomillae ethanol extract are after the ethanol water of employing 75% carries out alcohol extraction to Semen Granati, Ganoderma and Flos Matricariae chamomillae respectively, successively the extract that obtains of decompression recycling ethanol, lyophilization.
Embodiment 1:
The present embodiment microcapsule-type anti-wrinkle eye cream is a kind of microcapsule of nucleocapsid structure, and cyst material is: 40 parts of sodium alginates, 10 parts of Carboxymethyl cellulose sodium and 6 parts of hyaluronic acids; Core materials is: 15 parts of mink oils, 8 parts of squalanes, 6 parts of lecithin, 4 parts of Jojoba waxes, 6 parts of glycerol, 3 parts of serines, 6 parts of corn porous starch, 2 parts of Semen Granati ethanol extract, 1 part of ganoderol extract, 2 parts of Flos Matricariae chamomillae ethanol extract, 1 part of coenzyme Q10 and 4 parts of span 20s.
Adopt and be prepared with the following method:
1) material of above-mentioned weight portion is taken;
2) add in deionized water by the sodium alginate taken, Carboxymethyl cellulose sodium and hyaluronic acid, heating for dissolving 5min at 70 DEG C, obtains capsule wall solution A; Wherein, the deionized water volume added is 30 times of sodium alginate, Carboxymethyl cellulose sodium and hyaluronic acid gross mass;
3) mink oil, squalane, lecithin, Jojoba wax, glycerol, serine, corn porous starch, Semen Granati ethanol extract, ganoderol extract, Flos Matricariae chamomillae ethanol extract, coenzyme Q10 and the span 20 mix homogeneously that will take, under 70 DEG C of water bath condition, stir 0.5h, obtain capsule-core mixture B; The mixing speed of wherein said stirring is 120r/min;
4) mixed by capsule wall solution A and capsule-core mixture B, after blender dispersion 20min, homogenizing 5min, obtains homogenizing fluid C; Wherein, the rotating speed of described blender is 300r/min, and the homogenization pressure of described homogenizing is 35MPa;
5) homogenizing fluid C is heated to 70 DEG C, using glue head dropper that the homogenizing fluid C after heating is slowly added dropwise to mass concentration is in the calcium chloride solution of 5%;
6) calcium chloride solution after step 5) instillation homogenizing fluid C is filtered, discard filtrate, collect oversize;
7) to the oversize deionized water wash 2 ~ 3 times that step 6) is collected, the anti-wrinkle eye cream of described microcapsule-type is obtained.
Embodiment 2:
A preparation method for microcapsule-type anti-wrinkle eye cream, be a kind of microcapsule of nucleocapsid structure, cyst material is: 50 parts of sodium alginates, 15 parts of Carboxymethyl cellulose sodium and 8 parts of hyaluronic acids; Core materials is: 20 parts of mink oils, 12 parts of squalanes, 9 parts of lecithin, 10 parts of Jojoba waxes, 8 parts of glycerol, 6 parts of serines, 8 parts of corn porous starch, 3 parts of Semen Granati ethanol extract, 3 parts of ganoderol extracts, 3 parts of Flos Matricariae chamomillae ethanol extract, 2 parts of coenzyme Q10s and 7 parts of span 20s.
Adopt and be prepared with the following method:
1) material of above-mentioned weight portion is taken;
2) add in deionized water by the sodium alginate taken, Carboxymethyl cellulose sodium and hyaluronic acid, heating for dissolving 10min at 80 DEG C, obtains capsule wall solution A; Wherein, the deionized water volume added is 40 times of sodium alginate, Carboxymethyl cellulose sodium and hyaluronic acid gross mass;
3) mink oil, squalane, lecithin, Jojoba wax, glycerol, serine, corn porous starch, Semen Granati ethanol extract, ganoderol extract, Flos Matricariae chamomillae ethanol extract, coenzyme Q10 and the span 20 mix homogeneously that will take, under 80 DEG C of water bath condition, stir 1h, obtain capsule-core mixture B; The mixing speed of wherein said stirring is 160r/min;
4) mixed by capsule wall solution A and capsule-core mixture B, after blender dispersion 30min, homogenizing 10min, obtains homogenizing fluid C; Wherein, the rotating speed of described blender is 350r/min, and the homogenization pressure of described homogenizing is 50MPa;
5) homogenizing fluid C is heated to 80 DEG C, using glue head dropper that the homogenizing fluid C after heating is slowly added dropwise to mass concentration is in the calcium chloride solution of 7%;
6) calcium chloride solution after step 5) instillation homogenizing fluid C is filtered, discard filtrate, collect oversize;
7) to the oversize deionized water wash 2 ~ 3 times that step 6) is collected, the anti-wrinkle eye cream of described microcapsule-type is obtained.
Embodiment 3:
A preparation method for microcapsule-type anti-wrinkle eye cream, be a kind of microcapsule of nucleocapsid structure, cyst material is: 42 parts of sodium alginates, 12 parts of Carboxymethyl cellulose sodium and 8 parts of hyaluronic acids; Core materials is: 18 parts of mink oils, 10 parts of squalanes, 8 parts of lecithin, 6 parts of Jojoba waxes, 8 parts of glycerol, 5 parts of serines, 6 parts of corn porous starch, 2 parts of Semen Granati ethanol extract, 1 part of ganoderol extract, 2 parts of Flos Matricariae chamomillae ethanol extract, 2 parts of coenzyme Q10s and 6 parts of span 20s.
Adopt and be prepared with the following method:
1) material of above-mentioned weight portion is taken;
2) add in deionized water by the sodium alginate taken, Carboxymethyl cellulose sodium and hyaluronic acid, heating for dissolving 10min at 75 DEG C, obtains capsule wall solution A; Wherein, the deionized water volume added is 35 times of sodium alginate, Carboxymethyl cellulose sodium and hyaluronic acid gross mass;
3) mink oil, squalane, lecithin, Jojoba wax, glycerol, serine, corn porous starch, Semen Granati ethanol extract, ganoderol extract, Flos Matricariae chamomillae ethanol extract, coenzyme Q10 and the span 20 mix homogeneously that will take, under 75 DEG C of water bath condition, stir 1h, obtain capsule-core mixture B; The mixing speed of wherein said stirring is 150r/min;
4) mixed by capsule wall solution A and capsule-core mixture B, after blender dispersion 25min, homogenizing 10min, obtains homogenizing fluid C; Wherein, the rotating speed of described blender is 330r/min, and the homogenization pressure of described homogenizing is 45MPa;
5) homogenizing fluid C is heated to 75 DEG C, using glue head dropper that the homogenizing fluid C after heating is slowly added dropwise to mass concentration is in the calcium chloride solution of 7%;
6) calcium chloride solution after step 5) instillation homogenizing fluid C is filtered, discard filtrate, collect oversize;
7) to the oversize deionized water wash 2 ~ 3 times that step 6) is collected, the anti-wrinkle eye cream of described microcapsule-type is obtained.
The present invention adopts corn porous starch, lubricant component in core materials and active component are adsorbed, and then the preparation method making microcapsule-type anti-wrinkle eye cream of the present invention in use, can make to be adsorbed on active component in corn porous starch and oils and fats slowly evenly discharges, and can not discharge in a large number the short time and bring too much nutrition and oil content to skin, and then the generation of fat granule can not be caused.
In order to strengthen the permeability of the microcapsule-type anti-wrinkle eye cream that the present invention obtains, the present invention is special by a large amount of experimental studies, choose mink oil, squalane, Jojoba wax is as core materials, and the collaborative compatibility relationship that further study between three, final discovery is when using " 15 ~ 20 parts of mink oils, 8 ~ 12 parts of squalanes and 4 ~ 10 parts of Jojoba waxes " time, the moist degree of this product can either be ensured, again can not be too greasy, and what is more important is when three plays collaborative compatibility effect with this ratio, the permeability of this product can be strengthened, and then enable skin fully absorb nutritional labeling, import respond well.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although applicant's reference preferred embodiment is to invention has been detailed description, those of ordinary skill in the art is to be understood that, technical scheme of the present invention is modified or equivalent replacement, and do not depart from the aim of technical solution of the present invention and scope, all should be encompassed in the middle of right of the present invention.
Claims (5)
1. a preparation method for microcapsule-type anti-wrinkle eye cream, is characterized in that, comprises the steps:
1) material of following parts by weight is taken: 40 ~ 50 parts of sodium alginates, 10 ~ 15 parts of Carboxymethyl cellulose sodium, 6 ~ 8 parts of hyaluronic acids, 15 ~ 20 parts of mink oils, 8 ~ 12 parts of squalanes, 6 ~ 9 parts of lecithin, 4 ~ 10 parts of Jojoba waxes, 6 ~ 8 parts of glycerol, 3 ~ 6 parts of serines, 6 ~ 8 parts of corn porous starch, 2 ~ 3 parts of Semen Granati ethanol extract, 1 ~ 3 part of ganoderol extract, 2 ~ 3 parts of Flos Matricariae chamomillae ethanol extract, 1 ~ 2 part of coenzyme Q10 and 4 ~ 7 parts of span 20s;
2) add in deionized water by the sodium alginate taken, Carboxymethyl cellulose sodium and hyaluronic acid, at 70 ~ 80 DEG C, heating for dissolving 5 ~ 10min, obtains capsule wall solution A; Wherein, the deionized water volume added is 30 ~ 40 times of sodium alginate, Carboxymethyl cellulose sodium and hyaluronic acid gross mass;
3) mink oil, squalane, lecithin, Jojoba wax, glycerol, serine, corn porous starch, Semen Granati ethanol extract, ganoderol extract, Flos Matricariae chamomillae ethanol extract, coenzyme Q10 and the span 20 mix homogeneously that will take, under 70 ~ 80 DEG C of water bath condition, stir 0.5 ~ 1h, obtain capsule-core mixture B; The mixing speed of wherein said stirring is 120 ~ 160r/min;
4) mixed by capsule wall solution A and capsule-core mixture B, after blender dispersion 20 ~ 30min, homogenizing 5 ~ 10min, obtains homogenizing fluid C; Wherein, the rotating speed of described blender is 300 ~ 350r/min, and the homogenization pressure of described homogenizing is 35 ~ 50MPa;
5) homogenizing fluid C is heated to 70 ~ 80 DEG C, using glue head dropper that the homogenizing fluid C after heating is slowly added dropwise to mass concentration is in the calcium chloride solution of 5 ~ 7%;
6) calcium chloride solution after step 5) instillation homogenizing fluid C is filtered, discard filtrate, collect oversize;
7) to the oversize deionized water wash 2 ~ 3 times that step 6) is collected, the anti-wrinkle eye cream of described microcapsule-type is obtained.
2. the preparation method of microcapsule-type anti-wrinkle eye cream according to claim 1, is characterized in that, step 2) at 75 DEG C, heat 10min.
3. the preparation method of microcapsule-type anti-wrinkle eye cream according to claim 1, it is characterized in that, the mixing speed stirred described in step 3) is 150r/min.
4. the preparation method of microcapsule-type anti-wrinkle eye cream according to claim 1, is characterized in that, with after blender dispersion 25min in step 4), and homogenizing 10min.
5. the preparation method of microcapsule-type anti-wrinkle eye cream according to claim 1, it is characterized in that, the rotating speed of blender described in step 4) is 330r/min, and the homogenization pressure of described homogenizing is 45MPa.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510721591.6A CN105213267A (en) | 2015-10-30 | 2015-10-30 | A kind of preparation method of microcapsule-type anti-wrinkle eye cream |
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| CN201510721591.6A CN105213267A (en) | 2015-10-30 | 2015-10-30 | A kind of preparation method of microcapsule-type anti-wrinkle eye cream |
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| CN105213267A true CN105213267A (en) | 2016-01-06 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115252439A (en) * | 2022-08-03 | 2022-11-01 | 中国药科大学 | Smearing type skin care product composition containing millimeter capsules and preparation method thereof |
| WO2023135170A1 (en) * | 2022-01-13 | 2023-07-20 | Givaudan Sa | Composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391288B1 (en) * | 1999-07-27 | 2002-05-21 | Shiseido Co., Ltd. | Microcapsule and method of making the same |
| CN103202469A (en) * | 2013-03-28 | 2013-07-17 | 吉林大学 | Egg yolk lecithin microcapsules and preparation method thereof |
| CN104398392A (en) * | 2014-12-01 | 2015-03-11 | 重庆小丸科贸有限公司 | Hydrogel microcapsule and application thereof in anti-ageing cosmetic |
-
2015
- 2015-10-30 CN CN201510721591.6A patent/CN105213267A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391288B1 (en) * | 1999-07-27 | 2002-05-21 | Shiseido Co., Ltd. | Microcapsule and method of making the same |
| CN103202469A (en) * | 2013-03-28 | 2013-07-17 | 吉林大学 | Egg yolk lecithin microcapsules and preparation method thereof |
| CN104398392A (en) * | 2014-12-01 | 2015-03-11 | 重庆小丸科贸有限公司 | Hydrogel microcapsule and application thereof in anti-ageing cosmetic |
Non-Patent Citations (2)
| Title |
|---|
| 吴克刚等: "《食品微胶囊技术》", 31 July 2006 * |
| 杨晓东等: "《日用化学品生产技术》", 31 July 2008 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023135170A1 (en) * | 2022-01-13 | 2023-07-20 | Givaudan Sa | Composition |
| CN115252439A (en) * | 2022-08-03 | 2022-11-01 | 中国药科大学 | Smearing type skin care product composition containing millimeter capsules and preparation method thereof |
| CN115252439B (en) * | 2022-08-03 | 2023-12-19 | 中国药科大学 | Smearing type skin care product composition containing millimeter capsules and preparation method thereof |
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