CN104780873A

CN104780873A - Systems and methods for attaining a predetermined porosity of a vascular device

Info

Publication number: CN104780873A
Application number: CN201380056973.0A
Authority: CN
Inventors: M·L·洛索尔多; R·库斯雷卡
Original assignee: Nellcor Puritan Bennett LLC
Current assignee: Nellcor Puritan Bennett LLC; Covidien LP
Priority date: 2012-10-30
Filing date: 2013-10-10
Publication date: 2015-07-15
Anticipated expiration: 2033-10-10
Also published as: WO2014070406A1; US9301831B2; US20150359646A1; US20140121745A1; US9114001B2; EP2914215B1; US9907643B2; US20140121746A1; EP2914215A1; CN104780873B

Abstract

A system for treating a patient is provided that includes an expandable vascular device having a body having a substantially uniform porosity that is adapted to change by adjusting an axial length of the body. The system also includes an expanding member positioned within a central lumen of the device, the expanding member configured to engage the body, as the body is radially expanded from a collapsed configuration, and to reduce a porosity of the body within a body region more than the body porosity is reduced outside the region.

Description

For obtaining the system and method for the predetermined porosity of vascular arrangement

The cross reference of association area

This application claims the U.S. Provisional Patent Application sequence No.61/720 submitted on October 30th, 2012,154, in the priority of the U.S. Patent Application Serial No.13/826971 of submission on March 14th, the 2013 and U.S. Patent Application Serial No.13/827030 in submission on March 14th, 2013, its full content is incorporated to the present invention by reference at this.

Background technology

Tube chamber in patient body can varying sized, shape and/or patency, and this change can cause the complication relevant with body function or infection.Such as, blood vessel wall, arterial wall may develop so-called aneurysmal pathologic increase especially.Observe aneurysm to expand from arterial wall.Because disease, damage or congenital malformation cause blood vessel wall thinning weak and produce aneurysm.Aneurysm has fragile thin-walled, has the trend of breaking, and usually because hypertension causes or worsen.Aneurysm can be found in the different piece of health; Modal is abdominal aortic aneurysm (AAA) and brain or brain stem aneurysm.The only usual not life-threatening of aneurysmal existence, but aneurysm can cause serious health consequences, the apoplexy such as caused because of the aneurysm rupture in brain.In addition, the aneurysm of breaking can cause death.

Summary of the invention

Such as illustrate this technology according to various aspects described below.Clause in order to convenient numbering (1,2,3 etc.) describes each example of the aspect of this technology.It is provided as example and unrestricted technology.It should be noted that any one in subparagraph all can be combined with combination in any and put in corresponding independent clause, such as clause 1,16 and 23.Other clause can be presented in a similar fashion.

1, be used for the treatment of a patient's system, described system comprises:

Expandable vascular arrangement, it comprises body, and described body has basic uniform porosity, changes described porosity by regulating the axial length of described body to be suitable for; With

Expansion member, described expansion member is positioned in the central lumen of described vascular arrangement, described expansion member is configured to when described body is from engaging described body during collapsed configuration expanded radially and reducing the porosity of the body in body regions, and the reduction degree of described porosity is greater than the reduction degree of the body porosity of described areas outside.

2, the system according to clause 1, wherein, described body comprises braiding structure.

3, the system according to clause 1, wherein, described body comprises cutting metal pipe.

4, the system according to clause 1, wherein, described body comprises self-expanding structure.

5, the system according to clause 1, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the axial length of the described expansion member be in expanded configuration.

6, the system according to clause 5, wherein, described expansion member is identical with the change of described body from body collapsed configuration to the axial length of body expanded configuration to the change of the axial length of described expanded configuration from described collapsed configuration.

7, the system according to clause 1, also comprises binding agent, and described binding agent is arranged between described expansion member and described region, for the part in described region is adhered to described expansion member.

8, the system according to clause 7, wherein, described binding agent comprises biodegradable material.

9, the system according to clause 1, also comprises corrugated tube, and described corrugated tube is arranged in described expansion member, and described bellows configuration becomes the axial shortening when described expansion member expansion.

10, the system according to clause 1, wherein, described expansion member comprises enlarged area when expanding, and described enlarged area has the diameter of the expansion in other region relative to described expansion member, and described enlarged area and described body regions are axially aligned substantially.

11, the system according to clause 10, also comprises binding agent, and described binding agent is arranged between the described enlarged area of described expansion member and described body regions.

12, the system according to clause 1, wherein, described expansion member comprises reduction region when expanding, described reduction region has the diameter of reduction relative to other region of described expansion member, and described reduction region and described body regions are axially aligned substantially.

13, the system according to clause 12, also comprises binding agent, and described binding agent is arranged in nearside or the distally in the described reduction region of described expansion member.

14, the system according to clause 1, wherein, described expansion member comprises two enlarged area when expanding, and described two enlarged area have relative to therebetween the diameter that swedged reduction region has expansion, and described reduction region and described body regions are axially aligned substantially.

15, the system according to clause 14, also comprises binding agent, and described binding agent is arranged between described enlarged area and described body.

16, for an induction system for vascular arrangement, described induction system comprises:

Conduit, described conduit has tube chamber;

Seal wire, described seal wire extends through the tube chamber of described conduit;

Vascular arrangement, described vascular arrangement has porosity, changes described porosity by regulating the axial length of described vascular arrangement; With

Expansion member, described expansion member is arranged in the distal part of described conduit, and described expansion member is configured to the axial shortening when described expansion member expanded radially;

Wherein, described expansion member is configured to engage the region of described vascular arrangement and the device porosity reduced when described expansion member axial shortening in described region, and the reduction degree of described porosity is greater than the reduction degree of the porosity of described areas outside.

17, the system according to clause 16, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the described axial length of the described expansion member be in expanded radially structure.

18, the system according to clause 17, wherein, the change of the axial length that described expansion member constructs from collapsed configuration to expanded radially is identical with the change of described device from device collapsed configuration to the axial length of device expanded configuration.

19, the system according to clause 16, also comprises binding agent, and described binding agent is arranged between described expansion member and described region, for the part in described region is adhered to described expansion member.

20, the system according to clause 16, wherein, described expansion member comprises enlarged area when expanded radially, and described enlarged area has the diameter of expansion relative to other region of described expansion member, and the region of described enlarged area and device is axially aligned substantially.

21, the system according to clause 16, wherein, described expansion member comprises reduction region when expanded radially, described reduction region has the diameter of reduction relative to other region of described expansion member, and the region of described reduction region and device is axially aligned substantially.

22, the system according to clause 16, wherein, described expansion member comprises two enlarged area when expanded radially, described two enlarged area have relative to therebetween the diameter that swedged reduction region has expansion, and the region of described reduction region and device is axially aligned substantially.

23, for the manufacture of a method for vascular arrangement, comprising:

Be arranged in by vascular arrangement in expansion member, described device comprises body, and described body has basic uniform porosity, changes described porosity by regulating the axial length of described body to be suitable for; With

A part for described body is adhered to described expansion member, make the bonding when described expansion member expanded radially between body part and described expansion member reduce the porosity of the body in described body part, the reduction degree of described porosity is greater than the reduction degree of the porosity of described portion outboard.

24, the method according to clause 23, wherein, bonds when described expansion member is in expanded configuration.

25, the method according to clause 24, wherein, is in the described expansion member uniform extension when unfettered in described expanded configuration.

26, the method according to clause 23, wherein, bonds when described expansion member is in collapsed configuration.

27, the method according to clause 23, wherein, the adhesive construct between described body part and described expansion member becomes the disconnection when described expansion member expands at least partly.

28, the method according to clause 23, wherein, the adhesive construct one-tenth between described body part and described expansion member disconnects when described expansion member expand into 80% of the complete expanded configuration being greater than described expansion member.

29, the method according to clause 23, wherein, the adhesive construct one-tenth between described body part and described expansion member disconnects because of the shear strain in described bonding when described expansion member expands.

30, for the manufacture of a method for vascular arrangement, comprising:

Make the region of vascular arrangement and the region alignment of expansion member, described vascular arrangement has porosity, changes described porosity by regulating the axial length of described device; With

The region of described device is adhered to the region of described expansion member, make when described expansion member expanded radially, bonding between described device and described expansion member reduces the porosity in the region of described expansion member, and the reduction degree of described porosity is greater than the reduction degree of the porosity of the areas outside in described expansion member.

31, the method according to clause 30, wherein, bonds when described expansion member is in expanded radially structure.

32, the method according to clause 30, wherein, bonds when described expansion member is in collapsed configuration.

33, the method according to clause 30, wherein, the adhesive construct between the region of described device and the region of described expansion member becomes the disconnection when described expansion member expands at least partly.

34, the method according to clause 30, wherein, the adhesive construct one-tenth between the region of described device and the region of described expansion member disconnects when described expansion member expand into 80% of the complete expanded configuration being greater than described expansion member.

35, the method according to clause 30, wherein, the adhesive construct one-tenth between the region of described device and the region of described expansion member disconnects because of the shear strain in described bonding when described expansion member expands.

36, one is used for the treatment of aneurysmal method, and described method comprises:

Vascular arrangement is positioned in the blood vessel aneurysm mouth place, described vascular arrangement comprises body, and described body has basic uniform porosity, changes described porosity by regulating the axial length of described body to be suitable for; With;

Make the expansion member expansion be positioned in the central lumen of described body; With

By making described body engage with described expansion member, reduce the body porosity in body regions when described body expanded radially, the reduction degree of described porosity is greater than the reduction degree of the body porosity of described areas outside.

37, the method according to clause 36, wherein, described location is included in before described device expands and makes described region relative to described aneurysm mouth axial dipole field.

38, the method according to clause 36, also comprises by making the corrugated tube be positioned in described expansion member axially collapse and reduces the axial length of described expansion member.

39, the method according to clause 36, also comprises dissolved adhesive, and the part of described body is adhered to described expansion member by described binding agent.

40, the method according to clause 36, also comprises and makes described volume expansion, and wherein, described body comprises braiding structure or the cutting metal pipe of self-expanding.

41, the method according to clause 36, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the axial length of the described expansion member be in expanded radially structure.

42, the method according to clause 41, wherein, described expansion member is identical with the change of described body from body collapsed configuration to the axial length of body expanded configuration to the change of the axial length of described expanded configuration from described collapsed configuration.

43, one is used for the treatment of aneurysmal method, and described method comprises:

Vascular arrangement is positioned in the blood vessel aneurysm mouth place, described vascular arrangement has porosity, changes described porosity by regulating the axial length of described device;

The intraluminal expansion member being positioned at described device is expanded; With

By making a region along with described expansion member axial shortening, reduce the porosity of the device in described region, the reduction degree of described porosity is greater than the reduction degree of the porosity of described areas outside.

44, the method according to clause 43, wherein, described location is included in before described expansion member expands and makes described region relative to described aneurysm mouth axial dipole field.

45, the method according to clause 43, also comprises by making the corrugated tube be positioned in described expansion member axially collapse and reduces the axial length of described expansion member.

46, the method according to clause 43, also comprises dissolved adhesive, and the part of described device is adhered to the part of described expansion member by described binding agent.

47, the method according to clause 43, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the axial length of the described expansion member be in expanded configuration.

48, the method according to clause 47, wherein, described expansion member is identical with the change of described device from device collapsed configuration to the axial length of device expanded configuration to the change of the axial length of described expanded configuration from described collapsed configuration.

Should be understood that, the structure of this technology will become apparent those of skill in the art from the following detailed description, wherein, be show and described the multiple structure of this technology by illustrated mode.To recognize, this technology can have other different structure and can with regard to many aspects to some details corrects, and this does not depart from the scope of this technology.Therefore, accompanying drawing and describe in detail essence be intended to explaination and unrestricted.

Accompanying drawing explanation

Be described in detail with reference to the accompanying drawings:

Figure 1A shows the system for controllably disposing the vascular arrangement be in collapsed configuration of some embodiments according to this technology;

Figure 1B shows the system for controllably disposing the vascular arrangement mediated in structure of some embodiments according to this technology;

Fig. 1 C shows the system for controllably disposing the vascular arrangement be in expanded configuration of some embodiments according to this technology;

Fig. 2 shows the vascular arrangement of some embodiments according to this technology;

Fig. 3 A shows the parison for the manufacture of expansion member of some embodiments according to this technology;

Fig. 3 B shows the example process for the manufacture of expansion member of some embodiments according to this technology;

Fig. 3 C shows the example process for the manufacture of expansion member of some embodiments according to this technology;

Fig. 3 D shows the expansion member of some embodiments according to this technology;

Fig. 3 E shows the expansion member of some embodiments according to this technology;

Fig. 4 A shows the vascular arrangement being connected to expansion member according to the use binding agent of some embodiments of this technology;

Fig. 4 B shows the vascular arrangement being connected to expansion member according to the use binding agent of some embodiments of this technology;

Fig. 4 C shows the vascular arrangement being connected to expansion member according to the use binding agent of some embodiments of this technology;

Fig. 4 D shows the vascular arrangement being connected to the expansion member of expansion according to the use binding agent of some embodiments of this technology;

Fig. 5 A shows the expansion member with enlarged area of some embodiments according to this technology;

Fig. 5 B shows the expansion member with layout enlarged area in the blood vessel of some embodiments according to this technology;

Fig. 6 A shows the expansion member with reduction region of some embodiments according to this technology;

Fig. 6 B shows has according to some embodiments of this technology the expansion member being arranged in endovascular reduction region;

Fig. 7 A shows the expansion member with two enlarged area of some embodiments according to this technology;

Fig. 7 B shows the expansion member with layout two enlarged area in the blood vessel of some embodiments according to this technology;

Fig. 8 A shows the example of the conduit of some embodiments according to this technology;

Fig. 8 B shows another example of the conduit of some embodiments according to this technology;

Fig. 9 shows the sectional view according to the blood vessel of some embodiments of this technology and the conveying of vascular arrangement;

Figure 10 shows the sectional view according to the blood vessel of some embodiments of this technology and the conveying of vascular arrangement;

Figure 11 shows the sectional view according to the blood vessel of some embodiments of this technology and the conveying of vascular arrangement;

Figure 12 shows the sectional view according to the blood vessel of some embodiments of this technology and the conveying of vascular arrangement;

Figure 13 shows the sectional view according to the blood vessel of some embodiments of this technology and the conveying of vascular arrangement;

Figure 14 shows the sectional view according to the blood vessel of some embodiments of this technology and the conveying of vascular arrangement.

Detailed description of the invention

The detailed description provided hereinafter is intended to describe multiple structure of this technology and is not intended to represent the unique configuration can putting into practice this technology.Accompanying drawing to be included in detailed description and as the part described in detail.Detailed description comprises specific detail, with this technology of complete understanding.But, those of skill in the art be it is evident that and can put into practice this technology when not comprising these specific detail.In some cases, show well-known structure and parts with block diagram form, to avoid the concept of fuzzy technology.

Aneurysm can such as be located along blood vessel sidewall.Aneurysmal cervical region generally defines the opening between about 2mm to 25mm, but other size and scope are also feasible.Dissection tube chamber is connected to aneurysmal bottom by cervical region.In certain embodiments, " vascular " or " tube chamber " can refer to blood vessel (comprising artery and vein) or other suitable organ with tube chamber, such as, gastrointestinal tract (such as, esophagus, stomach, small intestinal, colon, rectum), bile duct, bladder, ureter, urethra, trachea, bronchioles etc.Dissect intraluminal blood flow flow through cervical region and enter into bottom.In response to the constant blood flow flow in bottom aneurysm, aneurysm wall continuous expansion and there is the risk of breaking.When the pressure acted on aneurysm wall that the blood in aneurysm produces is greater than wall intensity, aneurysm rupture.

Reduce the blood flow flow in aneurysm or aneurysm cause reducing the power that acts on aneurysm wall and reduce risk of rupture accordingly.Can power be reduced by locking device and enter aneurysmal blood volume.During disposing, locking device can depend on the technology of doctor, to guarantee the porosity needed for the acquisition of aneurysm neck place.If the porosity at cervical region place is too high, then locking device may fail fully to reduce to flow into the blood flow in bottom.The proximal portion that longitudinal compressing force can be applied to locking device by the direction of distally part assigns to reduce the porosity of some locking devices.Because the porosity of locking device can be revised by applying compression stress, so continue reliably to realize the technology that required porosity height depends on doctor.

The method and system of this technology makes device continue reliably to block the blood flow entering into aneurysm by the deployment controlling vascular arrangement, prevents thus or that the probability that reduces aneurysm rupture solves in the problems referred to above is some or all.This system comprises expandable vascular arrangement and expansion member, and described expansion member is positioned in the central lumen of vascular arrangement.Expansion member is configured to the predetermined porosity in the region obtained during disposing for device.Therefore, the deployment using expansion member to control vascular arrangement reduces or stopped laminar flow to flow in aneurysm with the predetermined porosity obtained for region, allows the blood in aneurysm to start to stagnate thus.With to continue to flow through aneurysmal bottom contrary, blood stasis causes Aneurysmformation thrombosis, and this also contributes to preventing aneurysm rupture.

Figure 1A to Fig. 1 C shows the system 100 for controllably disposing vascular arrangement 110 of some embodiments according to this technology.System 100 comprises inflatable vascular arrangement 110, be positioned at expansion member 120 in the central lumen of vascular arrangement 110 and conduit 130.

With reference to Fig. 2, vascular arrangement 110 comprises body 111, and described body 111 has basic uniform porosity.The component 112 that body 111 can be opened by multiple basic uniform intervals is formed.By the porosity regulating the axial length of body 111 to change body 111.Such as, body 111 can be configured to during diameter or expanded radially and/or reduce porosity because of axial shortening afterwards.Body 111 can be self-expanding stent, and described self-expanding stent is made up of two or more circles or avette silk 112, and therefore, body 111 has the first collapsed configuration and the second expanded configuration.Silk 112 can be made up of known flexible material, and described known flexible material comprises shape-memory material, such as Nitinol, platinum and rustless steel.Body 111 can be formed by platinum/8% tungsten and 35N LT (cobalt-nickel alloy, it is the low titanium version of MP35N alloy) B alloy wire manufacture.In other embodiments, one or more in silk 112 can be formed by biocompatible metal material or bioavailable polymer.Silk 112 can be woven into final lattice-like structure.In at least one embodiment, in braiding or during being wound around body 111,1 rhizoid can be used to be positioned at 2 rhizoids on 2 rhizoids and to be positioned at the system loosely braided wires 112 of (1-over-2-under-2) below 2 rhizoids.But, under the prerequisite not deviating from the scope of the present disclosure, in other embodiments, other weaving method can be used.

Alternatively, body 111 can such as by the pre-formed pipe of cut or plate, to be interconnected by laser welding multiple component 112 or by such as chemical etching, grind, pierce through, other proper methods of electrical forming or other means interconnects multiple component 112 and formed.In another example, body 111 can comprise tubular bracket.

Body 111 has such porosity, and described porosity construction becomes to reduce the hematodinamics stream such as flow in aneurysm.The porosity determined by multiple component 112 of body 111 can be regulated by axial shortening body 111.The end of body 111 can be cut into pieces and therefore keep free expanded radially and contraction.Body 111 because of used material, body 111 porosity and there is no the fact of anchor portion and there is high flexibility.

With reference to Figure 1A to Fig. 1 C, expansion member 120 is configured to the body 111 engaging vascular arrangement 110 when body 111 expands from the first collapsed configuration.Expansion member 120 can comprise elastomeric ball bag, and described elastomeric ball bag very has elasticity, makes the axial length of the expansion member 120 be in collapsed configuration be about 200%-500% of the axial length of the expansion member 120 be in expanded configuration.Expansion member 120 can be formed by polyurethane, silicone or other similar material.

Expansion member 120 is configured to when body 111 moves to the second expanded configuration from the first collapsed configuration with the mode generation geometric deformation similar with vascular arrangement 110.Such as, expansion member 120 can be configured between expansion member 120 is from collapsed configuration to the expanded configuration phase of expansion axially contraction in length, and the radial dimension of expansion member 120 or the recruitment of diameter equal the radial dimension of body 111 or the recruitment of diameter when body 111 moves to the second expanded configuration from the first collapsed configuration.In other words, the change during moving to expanded configuration from collapsed configuration of axial length and the radial dimension of expansion member 120 and body 111 are identical with the change of radial dimension from the axial length during the first collapsed configuration to the second expanded configuration.

Expansion member 120 can have inner member 125, and described inner member 125 is arranged in the central longitudinal axis of expansion member 120, and described inner member 125 is configured to expand or axial shortening between expansionary phase in expansion member 120.The degree that inner member 125 can be configured to axial shortening between expansion or expansionary phase is identical with the degree of expansion member 120 axial shortening.Inner member 125 such as can comprise corrugated tube, telescoping tube or other structure being configured to axial shortening or collapsing.The near-end of expansion member 120 and far-end can be attached, connect or adhere to portions of proximal and the distal part of inner member 125.

In certain aspects, in order to reduce the trend of expansion member 120 creep or stress relaxation, the material of expansion member 120 can be cross-linked.Crosslinked is conjugate, dual functional polymer chain or multifunctional polymer chain, and expansion member 120 polymer chain is linked to another by them.Can be formed by chemical reaction crosslinked, start chemical reaction by heating, pressure, pH value change, radiation or alternate manner.Such as, will not to be polymerized or partially polymerized resin to mix crosslinked chemical reaction between the polymer chain that causes forming expansion member 120 material with the specified chemical thing being called cross-linking agent.When needs prevent creep or stress relaxation further, at axial shortening and expanded radially structure or expansion member 120 can be transported in expanded configuration.In this illustration, expansion member 120 can be configured to when expansion member 120 is in its maximum gauge and " static " in the situation of its shortest length.

With reference to Fig. 3 A to Fig. 3 D, mould 310 can be used to manufacture expansion member 120.In this process, one-step polymerization property management (parison) 320 is put in mould.Parison is in work (operation) temperature and then carries out axial tension and internal pressurization " P ", to form expansion member 120 to parison by heating element.Use this process, expansion member 120 or can be orthogonal to the longitudinal axis of expansion member 120 or be orthogonal to the vicissitudinous shape of cross section of both longitudinal axis tool of expansion member along expansion member 120 length along the length of expansion member 120.It is axial or biaxially oriented that this expansion member 120 manufacture process can give the polymer chain that can form expansion member 120.

Alternatively, expansion member 120 can be manufactured by solution casting die method.Solution casting die method is such process, in described process, mould is rotated, thus causes the solution in mould to comply with the inner surface of mould because of centrifugal force.After solution cured one-tenth thin film, dismounting mould, discharges expansion member 120 thus.

Other known method can also for the manufacture of expansion member 120.In some instances, expansion member 120 is made up of the silk of the winding be embedded in elastomer polymer or braiding.In another example, expansion member 120 can be made up of braided wires, and described braided wires can by using extension stem or pipe and axially-extending or shortening, and described rod is attached to the near-end that the far-end of braided wires and pipe are attached to braided wires.

Expansion member 120 can have nearside cuff 122A and distally cuff 122B, for being attached to conduit 130.In another embodiment, expansion member 120 only can have nearside cuff 122A, as shown in FIGURE 3 E.This embodiment is particularly effective for the distal portions being attached to fixing wire catheter, as discussed below.

Fig. 4 A to Fig. 7 B shows vascular arrangement 110 according to some embodiments of this technology and expansion member 120.Before and during vascular arrangement 110 is disposed in patient's vascular system, expansion member 120 is positioned in the central lumen of vascular arrangement 110.Expansion member 120 can be configured so that vascular arrangement 110 controllably expands, and makes vascular arrangement 110 such as can obtain predetermined porosity in the specific region place near the therapentic part of aneurysm neck.Such as, during disposing, expansion member 120 can cause the porosity of the body 111 in the 115A-D of region to reduce, and obtain the predetermined porosity for region 115A-D thus, the reduction degree of described porosity is greater than the reduction degree of the porosity of the body 111 outside the 115A-D of region.

Alternatively, expansion member 120 can be configured so that vascular arrangement 110 controllably expands, vascular arrangement 110 is made to obtain predetermined porosity in more than one region, the nearside of all aneurysm neck in this way in described region and distally (may be higher at this place's pressure).

With reference to Fig. 4 A to Fig. 4 D, expansion member 120 can make vascular arrangement 110 controllably expand, and the predetermined porosity obtained for region 115A by the part engaging vascular arrangement 110 before deployment with period definitely.Such as, binding agent 117 may be used for an outer surface part for vascular arrangement 110 being engaged, connect, is attached or is adhered to expansion member 120 definitely.Binding agent 117 contributes to utilizing the axial shrinkage of expansion member 120 and expanded radially feature by expansion member 120 is engaged, connects, is attached or adheres to the porosity that vascular arrangement 110 controls vascular arrangement 110 definitely.

Binding agent 117 can comprise Biodegradable material or such material, and described material can be dissolved in health or blood flow.Such as, binding agent 117 can comprise sugar, Polyethylene Glycol, polyethylene glycol oxide, polyvinyl alcohol, polylactic acid (PLA), polyglycolic acid (PGA), polylactic acid-glycollic acid (PLGA), poly-(c-caprolactone) copolymer, polydioxanone, poly-fumaric acid propylene glycol ester PTMC copolymer, polyhydroxyalkanoate, polyphosphazene, condensing model, poly-(ortho esters), poly-(aminoacid) or " puppet " poly-(aminoacid).

In certain aspects, expansion member 120 can be configured to expand in expansion member 120 or allow the tissue in perfusion expansion member downstream between expansionary phase.Dissolved adhesive 117 is helped in addition by allowing perfusion downstream to organize.

With reference to Fig. 4 A, in one example, binding agent 117 can be arranged between expansion member 120 and region 115A.A part of region 115A is adhered to the outer surface of expansion member 120 by binding agent 117.Binding agent 117 can be applied on expansion member 120 and/or vascular arrangement 110, makes its only nearside of adhesive area 115A and/or distal part.With reference to Fig. 4 C, alternatively, binding agent 117 can be applied to region 115A whole region on or particular portion office.With reference to Fig. 4 B, according to resolvability and/or the fragility of binding agent 117, binding agent 117 can continuously or on the interval outer surface that be applied to expansion member 120 or vascular arrangement 110.Binding agent 117 can be applied by spraying, dipping or other process.

With reference to Fig. 4 D, in an aspect, in expansion member 120 uniform extension, expansion, demi-inflation and/or while being in expanded configuration, binding agent 117 can be applied on the outer surface of expansion member 120.Such as, when expansion member 120 to be in expanded configuration and to stretch along its uniform length, binding agent 117 can be applied on the outer surface of expansion member 120.In this illustration, binding agent 117 can intermittently be applied in the 115A of region, makes to form non-adhesion area, as shown in Figure 4 C.When expansion member 120 and vascular arrangement prepare to dispose in vascular system and when moving into collapsed configuration, non-adhesion area contributes to folding or collapse expansion member 120 and vascular arrangement 110.

Alternatively, to reduce, collapse part and/or while being in collapsed configuration in expansion member 120, binding agent 117 can be applied on the outer surface of expansion member 120.In this illustration, binding agent 117 can be applied in the 115A of region continuously, as shown in Figure 4 B.

In another example, while the part that expansion member 120 has along its length extending, binding agent 117 can be applied on the outer surface of expansion member 120.Expandable part can correspond to the region 115A of vascular arrangement 110.

In certain aspects, expansion member 120 and vascular arrangement 110 engage definitely, connect, are attached or adhere to, and make in binding agent 117, to there is not shear strain when expansion member 120 and vascular arrangement 110 are in expanded configuration.In other side, expansion member 120 and vascular arrangement 110 engage definitely, connect, are attached or adhere to, make in binding agent 117, to there is enough shear strains when expansion member 120 and vascular arrangement 110 expand completely or be in expanded configuration, to make binding agent 117 rupture or disconnect and discharge vascular arrangement 110 from expansion member 120 thus.In other side, expansion member 120 and vascular arrangement 110 engage definitely, connect, are attached or adhere to, make in binding agent 117, to there is enough shear strains when expansion member 117 and vascular arrangement 110 demi-inflation, to make binding agent 117 rupture or disconnect and discharged vascular arrangement 110 from expansion member 120 thus before expansion member 120 expands completely.Described shear strain can be axial strain, hoop strain or its combination.

Before deployment, expansion member 120 can move into collapsed configuration, and vascular arrangement 110 is disposed thereon.When being in collapsed configuration, than the other parts of body 111, the region 115A of body 111 will have higher count and lower porosity because region 115A is adhered to the binding agent 117 of expansion member 120.During the follow-up expansion of expansion member 120 and vascular arrangement 110, the axial length of the increase of the diameter along with vascular arrangement 110 and vascular arrangement 110 shortens and reduces by the overall porosity of body 111.But between the phase of expansion or afterwards, than other region of body 111, the porosity of region 115A also will reduce and keep less hole.

With reference to Fig. 5 A to Fig. 5 B, expansion member 120 can make vascular arrangement 110 controllably expand, and is increased to the diameter of the other parts being greater than vascular arrangement 110 by the diameter of the region 115B by vascular arrangement 110 and keeps the predetermined porosity for region 115B.Expansion member 120 can comprise enlarged area 123A when expanding, and described enlarged area 123A has the diameter of the expansion in other region relative to expansion member 120.Enlarged area 123A and region 115B axially aligns substantially.

The enlarged area 123A of expansion member 120 makes the diameter of region 115B be increased to the diameter of the other parts being greater than body 111.Cause the component 112 in the other parts being arranged in body 111 to be pulled to region 115B by the diameter of enlarged area 115B, thus reduce the porosity in the 115B of region.Therefore, expansion member 120 causes the porosity of the body 111 in the 115B of region to reduce, obtain the predetermined porosity for region 115B thus, the porosity that the reduction degree of the porosity of the body 111 in described region 115B is greater than the body 111 outside the 115B of region reduces degree.

In an aspect, binding agent 117 may be used for the enlarged area 123A region 115B of vascular arrangement 110 being engaged, connect, is attached or is adhered to expansion member 120 definitely.Binding agent 117 contributes to the axial shrinkage and the expanded radially feature that utilize expansion member 120, so that by expansion member 120 being engaged, connect, is attached or adheres to vascular arrangement 110 definitely and controlling the porosity of vascular arrangement 110.Bonding between the region 115B of vascular arrangement 110 and expansion member 120 is guaranteed to keep predetermined porosity at deployment time domain 115B.

Once near therapentic part, binding agent 117 just dissolves starting.When expansion member 120 expands, residue binding agent 117 will rupture, and also contribute to dissolved adhesive 117 thus.Expansion member 120 and vascular arrangement 110 will expand in an identical manner, thus axial length shortens while diameter increases.The enlarged area 123A of expansion member 120 will expand into the diameter of the other parts being greater than expansion member 120, cause the density increase in the 115B of region thus and the porosity in the 115B of region reduces, the reduction degree of the degree that described density increases and porosity is all greater than the density increase degree of the other parts of body 111 and the reduction degree of porosity.

With reference to Fig. 6 A to Fig. 6 B, expansion member 120 can make vascular arrangement 110 controllably expand, and keeps the predetermined porosity for region 115C in the reduction region 123B being stored in expansion member 120 by the excess stock of the region 115C by vascular arrangement 110.Such as, expansion member 120 can comprise reduction region 123B when expanding, described reduction region 123B has the diameter of reduction relative to other region of expansion member 120.Reduce region 123B and region 115C substantially axially align and provide the region of the excess stock of memory area 115C.In other words, vascular arrangement 110 can be arranged in expansion member 120, the material of region 115C can be got together and be collected in the reduction region 123B of expansion member 120 with high fine and close layout.

In an aspect, binding agent 117 may be used for the portions of proximal of body 111 and/or distal part to be adhered to expansion member 120, and region 115C is not adhered to expansion member 120.In another example, binding agent 117 can be arranged along reduction region 123B interval, as shown in Figure 6A.Binding agent 117 contributes to being remained on by the excess stock of region 115C in the reduction region 123B of expansion member 120, and make when disposing, region 115C keeps predetermined porosity.Therefore, when expansion member 120 expands, the excess stock being stored in the 123B place, reduction region of expansion member 120 of region 115C is disposed with the porosity relatively reduced.

Once be positioned near therapentic part, binding agent 117 just dissolves starting.When expansion member 120 expands, residue binding agent 117 will rupture, and contribute to dissolved adhesive 117 further thus.Expansion member 120 and vascular arrangement 110 will expand in an identical manner, thus axial length shortens and diameter increase.The reduction region 123B of the excess stock of the housing region 115C of expansion member 120 expands starting and disposes the excess stock be included in wherein.

With reference to Fig. 7 A to Fig. 7 B, expansion member 120 can make vascular arrangement 110 controllably expand, and keeps the predetermined porosity for region 115D in being stored between two enlarged area 124 being arranged in expansion member 120 region 123C by the excess stock of the region 115D by vascular arrangement 110.Such as, expansion member 120 can comprise two enlarged area 124 when expanding, and described two enlarged area 124 have the diameter of expansion relative to therebetween reduction region 123C.Reduce the diameter that region 123C has reduction, substantially axially align and provide the region of the excess stock of memory area 115D with region 115D.In other words, vascular arrangement 110 can be arranged in expansion member 120, the material of region 115D can be got together and be collected in the reduction region 123C of expansion member 120 with the layout of high compaction.

In an aspect, binding agent 117 may be used for the enlarged area 124 portions of proximal of body 111 and/or distal part being adhered to expansion member 120, and region 115D is not adhered to described enlarged area 124.Binding agent 117 contributes to being remained on by the excess stock of region 115D in the reduction region 123C of expansion member 120, and make when disposing, region 115D keeps predetermined porosity.Therefore, when expansion member 120 expands, the excess stock being stored in the 123C place, reduction region of expansion member 120 of region 115D is disposed with the porosity relatively reduced.

Once be positioned near therapentic part, binding agent 117 just dissolves starting.When expansion member 120 expands, residue binding agent 117 will rupture, and contribute to dissolved adhesive 117 further thus.Expansion member 120 and vascular arrangement 110 will expand in an identical manner, thus axial length shortens and diameter increase.The reduction region 123C of the excess stock of the housing region 115D of expansion member 120 expands starting and disposes the excess stock be contained in wherein.

Radiopaque label can adjoin portions of proximal or the distal part location of vascular arrangement 110, and can comprise any location positioning of region 115A-D between the near-end and far-end of vascular arrangement 110 in the length along vascular arrangement 110.Label can be attached to vascular arrangement 110 by the technology of such as binding agent, hot melt, interference engagement, securing member, intermediate member, coating and so on or other technology.

In certain embodiments, label comprises ultrasonic label, MRI (nuclear magnetic resonance, NMR) safety label thing or other label.In certain embodiments, ultrasonic label allows doctor under the effect of ultrasonic imaging method, determine the position of vascular arrangement 110 in patient body exactly.Material for ultrasonic label has the sound density fully different from vascular arrangement 110, to provide suitable video picture via ultrasonic technique.Exemplary materials comprises polymer, metal (such as the alloy of titanium, platinum, gold, tungsten and these metals), hollow glass ball or microballon and other material.

In certain embodiments, MRI safety label thing allows doctor under the effect of nuclear magnetic resonance, determine the position of vascular arrangement 110 in patient body exactly.Exemplary materials for the manufacture of MRI safety label thing has the magnetic fully different from vascular arrangement 110, to provide suitable imaging via MRI technology.Exemplary materials comprises polymer, metal (such as the alloy of titanium, platinum, gold, tungsten and these metals), nonferrous material and other material.

Aneurysmal technology is used for the treatment of now with reference to Fig. 8 A to Figure 14 discussion.Vascular arrangement 110 can be transported in therapentic part by use system 100.System 100 comprises conduit 130, and described conduit can be such as (OTW) conduit on seal wire, exchange (multitube chamber) conduit or fixing wire catheter fast.

With reference to Fig. 8 A, OTW conduit comprises axle 131.The portions of proximal of axle 131 has the manifold 132 being fixed to this.The distal part of axle 131 has the expansion member 120 being fixed to this.Axle 131 also comprises two tube chambers---guidewire lumen 133 and be provided for the expanding lumen 134 that expansion member 120 expands or expand.The near-end of each tube chamber 133,134 is all configured to have a common boundary with manifold 132.

With reference to Fig. 8 B, rapid-exchange catheter comprises axle 131, and described axle 131 has the expanding lumen 134 extended through wherein.The portions of proximal of axle 131 has the lining 135 being fixed to this.The distal part of axle 131 has the expansion member 120 being fixed to this.Axle 131 only has two tube chambers in distal part.Expanding lumen 134 and guidewire lumen 133 are from the remote extension of axle 131 to thin slice (skive) 136.At thin slice 136 place, guidewire lumen 133 terminates and seal wire is communicated with the outer surface of axle 131.Expanding lumen 134 is configured so that expansion member 120 expands or expands.

Fixing wire catheter comprises axle, and described axle only has expanding lumen, and described expanding lumen is fixed to lining and expansion member 120.

With reference to Fig. 9, before conveying, utilize binding agent or do not utilize binding agent 117 that vascular arrangement 110 is installed to expansion member 120.Oversheath 140 is arranged in vascular arrangement 110 and expansion member 120, to be limited in the first collapsed configuration by vascular arrangement 110 in the annular space between oversheath 140 and expansion member 120.Oversheath 140 also keeps vascular arrangement 110 and expansion member 120 to be in longitudinal tensile strain and the radial structure reduced.

Vascular arrangement 110 and expansion member 120 can in oversheath 140 routing motion, vascular arrangement 110 is delivered to the therapentic part in patient's vascular system, such as aneurysm.

The vascular system that oversheath 140 can be configured by patient is introduced into and advances.Oversheath 140 can be made up of multiple thermoplastic material, such as, PTFE (politef), FEP (perfluoroethylene-propylene), HDPE (high density polyethylene (HDPE)), PEEK (polyether-ether-ketone) etc., described thermoplastic material alternatively as the inner surface of oversheath 140 lining or there is the lining of the such as water wetted material of PVP (polyvinylpyrrolidone) or the abutment surface of some other plastic coating.In addition, according to results needed, arbitrary surface can be coated with the multiple combination of different materials.

Axle 131 comprises guidewire lumen 133, extends through wherein for allowing seal wire 150.Axle 131 can also comprise the diameter of reduction at distal region 137 place, to provide sufficient annular space, deposit vascular arrangement 110 in described annular space.In this illustration, expansion member 120 will be arranged in the diameter region 137 of the reduction of axle 131.

Radiopaque label can be arranged on diverse location place along the length of system 100.Such as, the distal end 138 of the expansion of axle 131 can radiopaque.In another example, radiopaque label can be arranged on the reduction diameter distal region 137 of axle, below the far-end and near-end of vascular arrangement 110.In another example, radiopaque label 160 can be arranged on axle 131, adjoins the longitudinal center of vascular arrangement 110 and/or expansion member 120.

In an aspect, vascular arrangement 110 can be configured with the region 115A-D with axially different length.Doctor can select suitable vascular arrangement 110 based on the axial length of aneurysmal neck size and region 115A-D.Such as, based on the length of the axial length of region 115A-D and the cervical region of aneurysm " Ln ", vascular arrangement 110 can be selected, make the axial length being in time domain 115A-D in the second expanded configuration at vascular arrangement 110 longer than the length of aneurysmal cervical region.

In one aspect of the method, system 100 can manufacture and transport when expansion member 120 and vascular arrangement 110 are in expanded configuration.In this illustration, in selective system 100, make the axial length of the region 115A-D carried than after aneurysmal length length, vascular arrangement 110 and expansion member 120 assembly proximad can be drawn in oversheath 140 by doctor, to compress vascular arrangement and expansion member 120 assembly.In alternative embodiments, system 100 can manufacture and transport when expansion member 120 and vascular arrangement 110 to be in collapsed configuration and to be preloaded on oversheath 140.

With reference to Fig. 9, system 100 advances to therapentic part via skin on seal wire 150, advances to the position of aneurysm 210 in this illustration.Particularly, vascular arrangement 110 can be positioned at mouth or the cervical region place of blood vessel 200 medium-sized artery tumor 210.In an aspect, radiopaque label 160 can be positioned at the distally of the distal-lateral wall of aneurysm 210, offsets thus at the mouth making the forefoot area 115A-D of vascular arrangement 110 expansion relative to aneurysm 210.During carrying, oversheath 140 prevents any soluble binding agent 117 be arranged between vascular arrangement 110 and expansion member 120 from dissolving.Particularly, oversheath 140 covers vascular arrangement 110 with expansion member 120 assembly and prevents any fluid (such as blood) from contacting with binding agent 117 thus.

With reference to Figure 10, after system 100 being directed to the therapentic part in patient body, while the position of retainer shaft 131, proximad retracts oversheath 140, exposes the distal part of shaft 131, expansion member 120 and vascular arrangement 110 thus.Retract oversheath 140, until the far-end of oversheath 140 is positioned at the nearside of vascular arrangement 110 and expansion member 120 assembly.

If vascular arrangement 110 comprises self-expanding stent, then the part not adhering to expansion member 120 of vascular arrangement can part expanded radially and part axial shortening.In this illustration, during disposing and afterwards, owing to being arranged in the binding agent 117 between region 115A-D and expansion member 120, therefore region 115A-D will keep the density higher than the other parts of body 111 and lower porosity.Binding agent 117 allows expandable members 120 that vascular arrangement 110 is controllably expanded thus and keeps the predetermined porosity for region 115A-D by engaging vascular arrangement 110 definitely.Alternatively, if vascular arrangement 110 does not comprise self-expanding stent, then vascular arrangement 110 is retained in expansion member 120.When retracting oversheath 140 and exposing vascular arrangement 110 and expansion member 120 assembly thus, binding agent 117 starts the fluid contact with such as blood.Binding agent 117 starts because dissolving with fluid contact.

With reference to Figure 11, when expansion member 120 uses expanding lumen 134 demi-inflation or expansion, expansion member 120 and therefore vascular arrangement 110 partly expanded radially and part axial shortening.Between the expansion member phase of expansion, inner member 125 amount that also axial shortening is identical with expansion member 120 and/or vascular arrangement 110.

With reference to Figure 12, regain system 100 subsequently to nearside, until radiopaque label 160 along the mouth of aneurysm 210 or the length of cervical region placed in the middle.In other words, reorientate vascular arrangement 110 make region 115A-D placed in the middle along the length of mouth after, mouth or the cervical region of aneurysm 210 will be covered when vascular arrangement 110 is in time domain 115A-D in the second expanded configuration.

Expansion member 120 is expanded to complete expanded configuration subsequently, disposes vascular arrangement 110 completely thus.Expansion member 120 is axial shrinkage by expanded radially, meanwhile because of the residue binding agent 117 be arranged between vascular arrangement 110 and expansion member, vascular arrangement 110 is remained to its outer surface.Expansion member 120 makes vascular arrangement 110 controllably expand, and makes vascular arrangement 110 remain on the predetermined porosity at 115A-D place, region.During disposing, expansion member 120 causes the porosity of the body 111 in the 115A-D of region to reduce, keep the predetermined porosity for region 115A-D thus, the reduction degree of described porosity is greater than the reduction degree of the porosity of the body 111 outside the 115A-D of region.

Between expansion member 120 phase of expansion or afterwards, the binding agent 117 be arranged between expansion member 120 and vascular arrangement 110 can dissolve and/or rupture, and discharges vascular arrangement 110 thus from expansion member 120.

Expansion member 120 causes region 115A-D thus not by the porosity affecting acquisition and pre-programmed of various doctor's induced movements that can occur during vascular arrangement 110 deployment.In other words, the porosity of region 115A-D is more insensitive for the action of doctor's applying during vascular arrangement 110 deployment.

With reference to Figure 13, once whole vascular arrangement 110 expands completely, then expansion member 120 is collapsed or is reduced.With reference to Figure 14, after this, conduit 130 can be regained together with oversheath 140, axle 131, expansion member 120 and seal wire 150 from body.

The region 115A-D of vascular arrangement 100 has significantly lower porosity than the other parts of body 111.Due to the lower porosity of region 115A-D, therefore less blood flow in aneurysm 210, makes it possible to, in aneurysm 210, obvious thrombosis occurs.

In an arrangement, vascular arrangement 110 can be made up of metal, polymer, pottery, permanent durable material, and can comprise arbitrary in not-bio-absorbable and bioabsorbable material or both.Exemplary materials including, but not limited to rustless steel, cochrome, Ai Erji noy nonmagnetic alloy, magnesium alloy, polylactic acid, polyglycolic acid, polyesteramide (PEA), poly(ether-urethane) (PEU), aminoacid system Biomimetic Polymers, tungsten, tantalum, platinum, polymer, biopolymer, pottery, bioceramic or metal glass.The some or all of of medical treatment device can carry out the such material of elution along with passage of time, such as, medicine, biological preparation, gene therapy thing, anti-thrombotic substance, coagulating agent, anti-inflammatory medicaments, immunoregulation medicine, anti-proliferate material, migration inhibitor, extracellular matrix regulating medicine, treatment promoter, again endothelialization promoter or other material.In certain embodiments, vascular arrangement 110 can be formed by the material with shape-memory properties.In certain embodiments, slag can be removed and finishing vascular arrangement 110 by process.In certain embodiments, vascular arrangement 110 can bear temper under the temperature conditions being usually applied to material, makes forever to set up marking structure.

Vascular arrangement 110 can have different length and diameter.Such as, vascular arrangement 110 can have specific cross-sectional diameter, and the described diameter measured when the complete free wxpansion of vascular arrangement 110 is in about 2mm to about 6mm.If vascular arrangement 110 has the diameter between 3mm and 4mm, then it can be applied in (that is, the internal diameter of microguide is about 0.21 inch) in the microguide of size 18.If the diameter of vascular arrangement 110 is between 5mm and 6mm, then it can be applied in (that is, the internal diameter of microguide is about 0.027 inch) in the microguide of size 27.But, other suitable cross-sectional diameter can be used and do not depart from the scope of this technology.In certain embodiments, the length that vascular arrangement 110 is from the close-by examples to those far off measured along the longitudinal axis of vascular arrangement 110 is in the scope of 15mm to 40mm, although other scope and size are also feasible.

Technical staff can implement described function by different way for each embody rule.All parts and square (such as, arrange with different order or separate by different way) can be arranged by different way and do not depart from the scope of this technology.Should be understood that, the concrete order of the step in disclosed process or level are the explanations of illustrative methods.Should be understood that based on design preference, concrete order or the level of the step in process can be rearranged.Can some in synchronization implementation step.Subsidiary claim to a method presents the element in each step with sample order, and is not intended to be limited to the concrete order or level listed.

Previous description makes those of skill in the art can put into practice various aspects described here.Previous description provides each example of this technology, and this technology is not limited to these examples.For those of skill in the art, the multiple modification of these aspects is apparent, and General Principle defined in this can be applied to other side.Therefore, claim be not intended to be limited to shown in this in, but the full breadth consistent with language claims should be given, wherein, the element of singular references is not intended to describe " one or only one " and clearly states except being far from it, but represents " one or more ".Unless expressly stated, otherwise term " some " refers to one or more.Positive pronoun (such as, he) comprise negative and neutral (such as, she with it) and vice versa.Title and subtitle (if existence) are just to convenient and unrestricted the present invention.

The phrase of such as " aspect " does not also mean that essential or this aspect is applied to the possessive construction of this technology for this technology in this aspect.Disclosure in one can be applied to possessive construction or one or more structure.An aspect can provide one or more example.The phrase of such as aspect can refer to one or more aspect and vice versa.The such as phrase of " aspect " does not represent that essential or this aspect is applied to the possessive construction of this technology for this technology in this aspect.Disclosure in one can be applied to all in or in one or more.An aspect can provide one or more example.The phrase of such as " aspect " can refer to one or more aspect and vice versa.The such as phrase of " structure " do not mean that this structure for this technology essential or this Structural application in the possessive construction of this technology.About one structure openly can be applied to possessive construction or one or more structure.Structure can provide one or more example.The phrase of such as " structure " can refer to one or more structures and vice versa.

Word " exemplary " expression as used herein " exemplarily or explain ".This be described as " exemplary " any in or design all need not be interpreted as than other side or design preferred or favourable.

With describe in the disclosure, those skilled in the art's all 26S Proteasome Structure and Functions of the element equivalent of various aspects that are known or that understand after a while are incorporated to the disclosure all by reference and are intended to be encompassed by claim.And, no matter whether clearly describe in the claims and enumerate this disclosure, do not have disclosed content to be intended to be devoted to public at this.Do not have key element will understand according to the regulations of 35U.S.C § 112 the 6th section, except non-usage phrase " for ... device " clearly describe key element or use when claim to a method phrase " for ... step " describe key element.And to a certain extent, use term " to comprise " in description or claim, " having ", when being applied to the transition word in claim, this term is intended to approximately be interpreted as that term " comprises ".

Claims

1. be used for the treatment of a patient's system, described system comprises:

2. system according to claim 1, wherein, described body comprises braiding structure.

3. system according to claim 1, wherein, described body comprises cutting metal pipe.

4. system according to claim 1, wherein, described body comprises self-expanding structure.

5. system according to claim 1, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the axial length of the described expansion member be in expanded configuration.

6. system according to claim 5, wherein, described expansion member is identical with the change of described body from body collapsed configuration to the axial length of body expanded configuration to the change of the axial length of described expanded configuration from described collapsed configuration.

7. system according to claim 1, also comprises binding agent, and described binding agent is arranged between described expansion member and described region, for the part in described region is adhered to described expansion member.

8. system according to claim 7, wherein, described binding agent comprises biodegradable material.

9. system according to claim 1, also comprises corrugated tube, and described corrugated tube is arranged in described expansion member, and described bellows configuration becomes the axial shortening when described expansion member expansion.

10. system according to claim 1, wherein, described expansion member comprises enlarged area when expanding, and described enlarged area has the diameter of the expansion in other region relative to described expansion member, and described enlarged area and described body regions are axially aligned substantially.

11. systems according to claim 10, also comprise binding agent, and described binding agent is arranged between the described enlarged area of described expansion member and described body regions.

12. systems according to claim 1, wherein, described expansion member comprises reduction region when expanding, described reduction region has the diameter of reduction relative to other region of described expansion member, and described reduction region and described body regions are axially aligned substantially.

13. systems according to claim 12, also comprise binding agent, and described binding agent is arranged in nearside or the distally in the described reduction region of described expansion member.

14. systems according to claim 1, wherein, described expansion member comprises two enlarged area when expanding, and described two enlarged area have relative to therebetween the diameter that swedged reduction region has expansion, and described reduction region and described body regions are axially aligned substantially.

15. systems according to claim 14, also comprise binding agent, and described binding agent is arranged between described enlarged area and described body.

16. 1 kinds of induction systems for vascular arrangement, described induction system comprises:

Conduit, described conduit has tube chamber;

17. systems according to claim 16, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the described axial length of the described expansion member be in expanded radially structure.

18. systems according to claim 17, wherein, the change of the axial length that described expansion member constructs from collapsed configuration to expanded radially is identical with the change of described device from device collapsed configuration to the axial length of device expanded configuration.

19. systems according to claim 16, also comprise binding agent, and described binding agent is arranged between described expansion member and described region, for the part in described region is adhered to described expansion member.

20. systems according to claim 16, wherein, described expansion member comprises enlarged area when expanded radially, and described enlarged area has the diameter of expansion relative to other region of described expansion member, and the region of described enlarged area and device is axially aligned substantially.

21. systems according to claim 16, wherein, described expansion member comprises reduction region when expanded radially, described reduction region has the diameter of reduction relative to other region of described expansion member, and the region of described reduction region and device is axially aligned substantially.

22. systems according to claim 16, wherein, described expansion member comprises two enlarged area when expanded radially, described two enlarged area have relative to therebetween the diameter that swedged reduction region has expansion, and the region of described reduction region and device is axially aligned substantially.

23. 1 kinds, for the manufacture of the method for vascular arrangement, comprising:

24. methods according to claim 23, wherein, bond when described expansion member is in expanded configuration.

25. methods according to claim 24, wherein, are in the described expansion member uniform extension when unfettered in described expanded configuration.

26. methods according to claim 23, wherein, bond when described expansion member is in collapsed configuration.

27. methods according to claim 23, wherein, the adhesive construct between described body part and described expansion member becomes the disconnection when described expansion member expands at least partly.

28. methods according to claim 23, wherein, the adhesive construct one-tenth between described body part and described expansion member disconnects when described expansion member expand into 80% of the complete expanded configuration being greater than described expansion member.

29. methods according to claim 23, wherein, the adhesive construct one-tenth between described body part and described expansion member disconnects because of the shear strain in described bonding when described expansion member expands.

30. 1 kinds, for the manufacture of the method for vascular arrangement, comprising:

31. methods according to claim 30, wherein, bond when described expansion member is in expanded radially structure.

32. methods according to claim 30, wherein, bond when described expansion member is in collapsed configuration.

33. methods according to claim 30, wherein, the adhesive construct between the region of described device and the region of described expansion member becomes the disconnection when described expansion member expands at least partly.

34. methods according to claim 30, wherein, the adhesive construct one-tenth between the region of described device and the region of described expansion member disconnects when described expansion member expand into 80% of the complete expanded configuration being greater than described expansion member.

35. methods according to claim 30, wherein, the adhesive construct one-tenth between the region of described device and the region of described expansion member disconnects because of the shear strain in described bonding when described expansion member expands.

36. 1 kinds are used for the treatment of aneurysmal method, and described method comprises:

37. methods according to claim 36, wherein, described location is included in before described device expands and makes described region relative to described aneurysm mouth axial dipole field.

38. methods according to claim 36, also comprise by making the corrugated tube be positioned in described expansion member axially collapse and reduce the axial length of described expansion member.

39. methods according to claim 36, also comprise dissolved adhesive, and the part of described body is adhered to described expansion member by described binding agent.

40. methods according to claim 36, also comprise and make described volume expansion, and wherein, described body comprises braiding structure or the cutting metal pipe of self-expanding.

41. methods according to claim 36, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the axial length of the described expansion member be in expanded radially structure.

42. methods according to claim 41, wherein, described expansion member is identical with the change of described body from body collapsed configuration to the axial length of body expanded configuration to the change of the axial length of described expanded configuration from described collapsed configuration.

43. 1 kinds are used for the treatment of aneurysmal method, and described method comprises:

44. methods according to claim 43, wherein, described location is included in before described expansion member expands and makes described region relative to described aneurysm mouth axial dipole field.

45. methods according to claim 43, also comprise by making the corrugated tube be positioned in described expansion member axially collapse and reduce the axial length of described expansion member.

46. methods according to claim 43, also comprise dissolved adhesive, and the part of described device is adhered to the part of described expansion member by described binding agent.

47. methods according to claim 43, wherein, the axial length being in the described expansion member in collapsed configuration is about 200% to 500% of the axial length of the described expansion member be in expanded configuration.

48. methods according to claim 47, wherein, described expansion member is identical with the change of described device from device collapsed configuration to the axial length of device expanded configuration to the change of the axial length of described expanded configuration from described collapsed configuration.