CN104288854B - High precision closed loop blood constituent separates blood-sampling method and blood-taking device in real time - Google Patents
High precision closed loop blood constituent separates blood-sampling method and blood-taking device in real time Download PDFInfo
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- CN104288854B CN104288854B CN201410583668.3A CN201410583668A CN104288854B CN 104288854 B CN104288854 B CN 104288854B CN 201410583668 A CN201410583668 A CN 201410583668A CN 104288854 B CN104288854 B CN 104288854B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
- A61M1/382—Optimisation of blood component yield
- A61M1/385—Optimisation of blood component yield taking into account of the patient characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/005—Anatomical parts of the body used as an access side to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
Abstract
The present invention relates to a kind of high precision closed loop blood constituent and separate blood-sampling method and a kind of blood-taking device in real time, described method is for separating in real time to the blood of extraction in blood donor's body, blood constituent scene should be fed back and feed back in blood donor's body, desired blood component is stored in corresponding desired blood component container, blood constituent index in real-time Non-invasive detection blood donor's body during blood drawing, stop blood sampling when the blood constituent index in blood donor's body drops to safe gate value, the blood constituent separating is detected in real time, control the speed of service of centrifugal blood seperator according to this, to reach optimal separation effect.Described blood-taking device includes blood drawing unit, blood separative element, memory cell, feedback unit, composition quality detector unit, fluid infusion unit, real-time physiological monitoring unit and CPU.The present invention can accurately determine the maximum amount of donating blood according to the physical signs of blood donor, and can improve and ensure the disintegrate-quality of blood under the premise that security is guaranteed.
Description
Technical field
The present invention relates to a kind of high precision closed loop blood constituent and separate blood-sampling method and blood-taking device in real time.
Background technology
Existing blood-taking device is usually blood drawing blood pump and stores up blood bag accordingly, and blood drawing blood pump passes through bloodletting tube and blood drawing
Blood is extracted out in human body by syringe needle, sends into storage blood bag storage, and gather due to this mode is whole blood, is actually needed then
The part useful component being probably in blood, thus development has played a kind of novel separation Blood collection, by blood separation skill
The equipment that art is taken a blood sample is mainly blood separator, will use whole blood separate after, it is not necessary to composition (such as blood plasma) return
It is passed in blood donor's body, thus reduce and donate blood the adverse effect to blood donor, and improve the effect that utilizes of blood, existing this skill
Art has following defects that one is the maximum amount of donating blood that cannot accurately determine blood donor, and once maximum blood sampling volume often controls
One level relatively guarded, is unfavorable for maximally utilising, in the case of ensureing safe, resource of donating blood, especially for
Some special blood, owing to donating blood, source is considerably less, it is easy to the phenomenon of inadequate blood source occur, and for autologous feedback, then especially
Being difficult to obtain enough feedback blood volumes from a patient, two is that blood separator only has open loop, metered dose, does not has in separation process
Having and detecting separated component in real time, disintegrate-quality is difficult to control to.
Content of the invention
Overcome the drawbacks described above of prior art for the purpose of the present invention, provide a kind of high precision closed loop blood constituent real-time
Separate blood-sampling method and blood-taking device, in order under the premise that security is guaranteed, according to the physical signs of blood donor, accurately determine
The maximum amount of donating blood.
Further aim of the present invention is to detect the blood constituent separating in real time, by FEEDBACK CONTROL, improve and
Ensure disintegrate-quality.
The technical solution adopted in the present invention is:
A kind of high precision closed loop blood constituent separates blood-sampling method in real time, and its blood to extraction in blood donor's body is carried out
Separating in real time, being separated into different blood constituents, described different blood constituent includes feeding back blood constituent and one or many
Plant desired blood component, blood constituent (not needing blood constituent that is that gather and that should feed back in blood donor's body) should be fed back existing
Field feeds back in blood donor's body, desired blood component is stored in corresponding desired blood component container, in blood donor's body
During extraction blood, the blood constituent index in real-time Non-invasive detection blood donor's body, with the blood constituent in blood donor's body
Index (for example, the concentration index of one or more blood constituents), as the individual index limiting maximum blood sampling volume, works as blood donor
When internal blood constituent index drops to safe gate value (lower threshold), stop blood sampling.In addition, except the present invention is raw according to blood donor
Outside the maximum blood sampling volume that reason information particularly internal blood constituent detection information determines, in blood sampling also should while according to existing
Other standards and the corresponding situation stopping blood sampling of specification (if any) detect accordingly and judge, any one in appearance
When planting the situation that should stop taking a blood sample, blood sampling all should be stopped according to corresponding standards and norms.
Preferably, the blood constituent in separation and/or after separation is detected in real time, according to detection information, blood is divided
Carrying out online real-time feedback control from device, the speed of service of the centrifugal blood seperator that regulation separates for blood, to reach
Optimal separation effect.
Preferably, the blood constituent when described desired blood component includes blood platelet, in described separation and/or after separation
Real-time detection at least include to separate in and/or separate after hematoblastic purity detecting.
Preferably, the algorithm of the blood constituent index in described real-time Non-invasive detection blood donor's body uses dynamic spectrum integration
Dissolving equation with many unknowns method from normalizing, being provided with m spectral frequency f1, f2...fm in full spectral range of analysis, corresponding spectral power is
P1, p2...pm, amass at 0-fdc (such as 0.5Hz) and fac1 (such as 0.5Hz)-fac2 (such as 25Hz) respectively to i-th power spectrum pi
Point, respectively pidc and piac,
Pidc=∫ pidf f ∈ (0-fdc)
Piac=∫ pidf f ∈ (fac1-fac2)
For noisy dynamic spectrum integration, then the half-power region of piac limit of integration selection pulse Spectral structure:
Piac=∫ pidf f ∈ (f0.51-f0.5h), in formula, f0.51, f0.5h are respectively upper and lower half power points,
Take both log ratio ln (piac)/ln (pidc)=ri, column matrix equation:
I-th kind of composition Ci=a1*r1+a2*r2+...+an*rn
Solve n equation and obtain composition ci.
Preferably, the described algorithm detecting the blood constituent in separation and/or after separation in real time uses spectrum to amass
Proportion by subtraction example Y-factor method Y, automatically controls the speed of service of centrifugal blood seperator system, reaches the purpose of control accuracy, particularly as follows:
If there being n kind composition in blood, x1, x2......xn are the spectral density function of various composition, when system operates,
Spectral concentration is relevant with running speed v, if the spectral density function of i-th kind of useful component (such as hemoglobin) is xi, this is useful
The spectrum energy of composition with the ratio of total spectrum energy is:
Y=∫ xidf/{ ∫ x1df+ ∫ x2df+... ∫ xndf}, f is spectral frequency
Y is differentiated, dy/dv={ ∫ xidf/ [∫ x1df+ ∫ x2df+... ∫ xndf] }/dv
Make dy/dv=0, draw best execution speed,
Heterogeneity affect difference need weight to consider in the case of, the spectrum energy of this useful component and total spectrum energy it
Ratio is then:
Y=∫ xidf/{k1* ∫ x1df+k2* ∫ x2df+...kn* ∫ xndf}, wherein k1, k2...kn are weight system
Number, other formula are constant.
A kind of high precision closed loop blood constituent separates blood-taking device in real time, and it uses any one method above-mentioned, comprising:
Blood drawing unit, is provided with blood drawing blood pump, and described blood drawing blood pump is provided with bloodletting tube；
Blood separative element, is provided with the seperator for separating blood constituent, and the preferred centrifugal blood of described seperator separates
Machine, the import of described seperator connects the output of described blood drawing blood pump, carries out composition to the blood from described blood drawing blood pump and divides
From being provided with multiple output channel for exporting different blood constituent, such as include that one should feed back blood constituent for output
Output channel and one or more output channel for exporting desired blood component, when desired blood component is multiple,
Different blood constituents is respectively by different blood constituent output channel output；
Memory cell, be provided with one or more storage blood pump and with the one or more storage supporting one of blood pump or
The storage container of multiple desired blood components, such as storage blood bag, the import of described storage blood pump connects the corresponding blood of described seperator
The output channel of liquid composition, described storage blood delivery side of pump connects the storage container of corresponding desired blood component；
Real-time physiological monitoring unit, is used for Real-time Collection blood donor's physiologic information, at least includes that internal blood constituent is real-time
Noninvasive detection device, the real-time noninvasive detection device of described internal blood constituent is provided with signal transmission cable and/or radio communication mold
Block, for communicating to connect with central control unit；
Central control unit, is mainly made up of middle control computer or middle control data processor, is used for controlling blood drawing blood pump
Work, in order to extract blood in blood donor's body, receive from blood donor's physiologic information of described physiology monitoring unit and carry out
Analyse and compare, when blood donor's physical signs drops to draw blood safe gate value (lower threshold) or the blood constituent of collection reaches to set
During fixed amount, control blood drawing blood pump quits work, and described blood donor's information at least includes that described internal blood constituent is noninvasive in real time
The internal blood constituent indication information of the blood donor that detection device is obtained.
Preferably, this device also includes composition quality detector unit, and described composition quality detector unit is provided with blood and divides
From composition real-time detection apparatus, for described seperator is newly separated (after including in separation process and/or separating and complete
) blood constituent detect in real time, described blood separated component real-time detection apparatus by the information that detects accordingly by having
Line and/or wireless mode reach described CPU, and described blood separated component is examined by described CPU in real time
The detection information surveying device is analyzed, and controls the running parameter of described seperator (for example, when described separation according to analysis result
When machine uses blood separator, adjust and separate rotating speed, to obtain required separated component purity).
Preferably, this device also includes feeding back unit, and described feedback unit is provided with feedback blood pump, described feedback blood pump
Import connects the output channel that should feed back blood constituent of described seperator, and described feedback blood delivery side of pump is connected with feedback pipe,
In blood collection procedure and/or blood drawing finish after, described central control unit control described blood drawing blood pump quit work, then control
Make described feedback blood pump work, in order to that separates described seperator should feed back blood components reinfusion in blood donor's body.
Preferably, this device also includes fluid infusion unit, and described fluid infusion unit is provided with fluid infusion blood pump, and described fluid infusion blood pump sets
Having feed tube and liquid supplementation pipe, when needs are to blood donor's fluid infusion, described central control unit control described blood drawing blood pump stops work
Make, then control the work of fluid infusion blood pump, in order to fluid infusion liquid is sent in blood donor's body, dress can be connected by described feed tube
The bag (or bottle etc.) having fluid infusion liquid carries out fluid infusion, can also be carried out by fluid infusion blood pump by preparing required medicine in bottle
Drug injection.
Preferably, described liquid supplementation pipe and feedback pipe are connected to same input pipe, and described input pipe is furnished with for detecting pipe
Middle bubble information and the ultrasonic bubble/pressure-detecting device of pressure information, described ultrasonic bubble/pressure-detecting device will be corresponding
Detection information reaches described CPU by wiredly and/or wirelessly mode, and described CPU is to from described
The detection information of input pipe ultrasonic bubble/pressure-detecting device is analyzed, when there is bubble in described input pipe, described in
The described fluid infusion blood pump of Central Processing Unit control or feedback blood pump quit work.
Preferably, described memory cell be provided with for detect described desired blood component storage container in liquid level information
Storage liquid level supersonic detection device, described storage liquid level supersonic detection device will detect information accordingly by wired and/or nothing
Line mode reaches described CPU, and described CPU is to the inspection from described storage liquid level supersonic detection device
Measurement information is analyzed, and when in the storage container of described desired blood component, liquid level reaches setting height, described central authorities are processed
Unit control described blood drawing blood pump quits work.
Preferably, the real-time noninvasive detection device of described internal blood constituent be at least can in detection body in blood red carefully
The internal blood constituent of one of born of the same parents, blood plasma and PC (any one index in cell, blood plasma and PC) is real
When noninvasive detection device, various suitable Non-invasive detection technology can be used, for example, by selecting appropriate frequency/frequency range
The finger of infrared radiation blood donor or other appropriate site of health, detect transmitted spectrum, utilize heterogeneity to difference frequency
The ultrared Absorption of rate is different, by analyzing the infrared ray absorbing situation to CF/frequency range, analyzes bleeding
The concentration of corresponding composition in liquid.
Preferably, described blood separated component real-time detection apparatus is the real-time detection that at least can detect blood platelet purity
Device, can use various suitable detection technique, is for example suitable for hematoblastic special materials detection technique and spectral detection dress
Put, be used for the online real-time feedback control of blood platelet purity, thus promote blood platelet purity and quality.
Beneficial effects of the present invention: due to the blood constituent index in real-time Non-invasive detection blood donor's body, and donate blood working as
Blood constituent index in person's body drops to safe gate value and stops blood drawing, for determining that maximum blood sampling volume provides the foundation of science, by
This achieves the accurate control to maximum blood sampling volume, particularly nervous in blood source and other in particular cases, be conducive to fully profit
By resource of donating blood；Due to the real-time detection that blood is separated, by way of FEEDBACK CONTROL, separator is controlled, favorably
In raising disintegrate-quality；Owing to providing the suitable calculation relating to controlling blood constituent index in blood donor's body and disintegrate-quality
Method, is advantageously implemented corresponding detection and control purpose, it is ensured that detection and control quality.
Brief description
Fig. 1 is the system architecture diagram of the present invention.
Detailed description of the invention
Seeing Fig. 1, the executable portion of this device specifically includes that blood drawing unit, blood separative element, memory cell, returns
Defeated unit and fluid infusion unit, these executable portions (unit) carry out under the control of the central processing unit drawing blood (collection whole blood),
Blood separates, the storage of desired blood component, the feedback that blood constituent should be fed back and fluid infusion if desired (for example nutrient solution and
Liquid, determines according to actual needs), central control unit is real-time to the internal blood constituent in real-time physiological monitoring unit
The information that blood separated component real-time detection apparatus in noninvasive detection device and composition quality detector unit is obtained is carried out point
Analysis, and according to corresponding working specification etc., the blood drawing blood pump of control blood drawing unit, the seperator of blood separative element, storage are single
The storage blood pump of unit, the fluid infusion blood pump work feeding back blood pump and fluid infusion unit feeding back unit, it is achieved blood drawing, separate, storage,
The functions such as feedback and fluid infusion.Wherein,
Blood drawing unit, is used for gathering whole blood.
Blood separative element, for realizing the separation of blood constituent in whole blood, mainly to the blood plasma in blood, blood red
Cell and blood platelet are separated from each other.
Real-time physiological monitoring unit, for the monitoring to blood donor's physiologic information during donating blood and to central authorities' process list
Unit feedback, be mainly used for the Non-invasive detection to internal blood constituent, it is also possible to include according to actual needs to blood donor other
The collection of physiologic information, such as in blood sampling, erythrocyte quantity in dynamic Non-invasive detection body, set up expert system computing mould
Type, under the oxygen delivery capacity ensureing body tissue, reduces blood sampling time and number of times as far as possible.
Feed back unit and fluid infusion unit: CPU is according to internal dynamic blood constituent Non-invasive detection information, dynamically
Calculate fluid infusion composition and consumption, by feeding back unit and fluid infusion unit should feed back blood constituent respectively and fluid infusion liquid inputs people
Body, reaches the target of safety blood taking.
The course of work of this device is:
First middle control data processor (computer) of CPU is instructed the real-time noninvasive inspection of internal blood constituent
Survey the internal blood constituent to blood donor for the device to detect, determine whether internal blood constituent index is in safe range,
If safety, then instruction unpack blood drawing pump starts blood drawing, can often take out 10ml blood, the blood constituent of blood donor of Non-invasive detection
Detection.Blood enters blood separative element from blood drawing syringe needle through blood drawing blood pump, and blood is divided by blood separative element by centrifuge
From blood separated component real-time detection apparatus (testing circuit) of described composition quality detector unit is to isolated blood constituent
Detect in real time, preferably (newly isolated) blood constituent being newly disengaged out is detected, in order to carry out anti-timely
Feedback, in the conceived case, preferably detects to the isolated blood constituent being pointed within described seperator, it is also possible to
To described seperator corresponding blood constituent output channel in blood constituent detect, test point is preferably near away from seperator
Position, according to the setting of seperator, after CPU analyzing and processing result input centrifuge automatically controlled list
Unit or by the automatic control unit of blood separated component real-time detection apparatus and/or centrifuge directly to corresponding detection information
It is analyzed, adjusted the speed of service of centrifuge by the automatic control unit of centrifuge, reach optimal separation precision, after separation
Various desired blood components are stored in different storage blood bag by different output channels under the effect of storage blood pump, after separation
Unwanted composition (should feed back blood constituent) accesses and feeds back blood pump, and computer instruction blood drawing pump stops, and starts and feeds back blood pump simultaneously
Open efferent duct ultrasonic bubble detection device (testing circuit) simultaneously and carry out bubble, blood components reinfusion blood donor's body should be fed back
In.
When the desired blood component obtaining meets the collection capacity of setting or checks the physical signs of blood donor and drops to safety
Stop blood drawing during thresholding.
When blood donor requires supplementation with medicine, computer instruction blood drawing blood pump 1 and feedback blood pump stop, and open fluid infusion blood pump defeated
Injection thing.
Described various blood pump all uses accurate blood transfusion apparatus.
Various unit of the present invention, except having of being expressly recited is main and/or in addition to the part/device of basic function,
Can also include various part/device supporting and/or attached accordingly, for example described device with main or basic function
Mounting assembly, the described device with main and/or basic function supporting control circuit, for realizing the connection that liquid transmits
Connection pipeline of pipe or other forms etc., these supporting and/or attached part/devices can realize according to prior art.
The present invention relates to various suitable pipeline can be used to connect for the connection transmitting blood or blood constituent, described
Pipeline for connecting can be rubber tube, plastic tube and metal tube etc., it is possible to is provided with various required conduit coupling, institute
State the temporarily providing room/temporary container that can be provided with or without liquid on the pipeline for connection.
The mechanical package of each unit of the present invention or integrated can be according to prior art.
Described central control unit is used for controlling each blood pump and hardware structure and/or the communication mode of seperator can foundations
Prior art, can be for being connected the control interface of each blood pump and separator respectively by controlling cable.
The information/data that the present invention is alleged and central control unit communicates to connect or relates between central control unit passes
Send, be the middle control computer of direct or indirect mode and described central control unit or the communication connection of middle control data processor or
And the information/data transmission between the middle control computer of described central control unit or middle control data processor, described middle control
Computer or middle control data processor can be provided with corresponding interface circuit or data converting circuit etc., it is achieved described communication
Connecting or information/data transmission, described communication mode and information/data load mode and corresponding hardware structure can be according to now
There is technology.
The present invention can arrange various display, warning and output/input device according to prior art.
Each optimization technique means disclosed by the invention, unless otherwise indicated and optimization technique means are another technology hand
Outside the restriction further of section, all can form some different technical schemes in any combination.
Claims (7)
1. a high precision closed loop blood constituent separates blood-taking device in real time, it is characterised in that include:
Blood drawing unit, is provided with blood drawing blood pump, and described blood drawing blood pump is provided with bloodletting tube；
Blood separative element, is provided with the seperator for separating blood constituent, and described seperator is centrifugal blood seperator, to
Carry out composition separation from the blood of described blood drawing blood pump, be provided with multiple output channel for exporting different blood constituent；
Memory cell, is provided with one or more storage blood pump and stores supporting one or more of blood pump with the one or more
The storage container of desired blood component, the import of described storage blood pump connects the efferent duct of the corresponding blood constituent of described seperator
Road, described storage blood delivery side of pump connects the storage container of corresponding desired blood component；
Real-time physiological monitoring unit, is used for Real-time Collection blood donor's physiologic information, at least includes that internal blood constituent is noninvasive in real time
Detection device, the real-time noninvasive detection device of described internal blood constituent is provided with signal transmission cable and/or wireless communication module, uses
In with central control unit communication connection；
Central control unit, is mainly made up of middle control computer or middle control data processor, is used for controlling blood drawing blood pump work,
Receive from blood donor's physiologic information of described physiology monitoring unit and analyse and compare, when blood donor's physical signs drops to take out
During the safe gate value of blood or when the blood constituent of collection reaches the amount setting, control blood drawing blood pump quits work, blood donor's information
At least include the internal blood constituent indication information of the blood donor that the real-time noninvasive detection device of described internal blood constituent obtained,
The algorithm of the blood constituent index in real-time Non-invasive detection blood donor's body uses dynamic spectrum integration to dissolve polynary from normalizing
Equation method, is provided with m spectral frequency f1, f2 ... fm in full spectral range of analysis, and corresponding spectral power is p1, p2 ... pm, to i-th
Power spectrum pi respectively at 0-fdc and fac1-fac2 integration, respectively pidc and piac,
pidc=∫pidf f∈(0-fdc)
piac= ∫pidf f∈(fac1-fac2)
For noisy dynamic spectrum integration, then the half-power region of piac limit of integration selection pulse Spectral structure:
Piac=∫ pidf f ∈ (f0.5l-f0.5h), in formula, f0.5l, f0.5h are respectively upper and lower half power points,
Take both log ratio ln (piac)/ln (pidc)=ri, column matrix equation:
I-th kind of composition Ci=a1*r1+a2*r2+ ...+an*rn
Solve n equation and obtain composition ci.
2. blood-taking device as claimed in claim 1, it is characterised in that also include composition quality detector unit, described composition quality
Detector unit is provided with blood separated component real-time detection apparatus, carries out for the blood constituent newly separated described seperator
Detection in real time, described blood separated component real-time detection apparatus will be detected information accordingly and be passed by wiredly and/or wirelessly mode
To described central control unit, the detection information to described blood separated component real-time detection apparatus for the described central control unit is entered
Row is analyzed, according to the running parameter of the described seperator of analysis result control,
The algorithm detecting the blood constituent in separation and/or after separation in real time uses spectrum integral proportionality coefficient method, from
The speed of service of dynamic control centrifugal blood seperator system, reaches the purpose of control accuracy, particularly as follows:
If having n kind composition, x1, x2 in blood ... xn is the spectral density function of various composition, when system operates, spectrum is close
Spend relevant with running speed v, if the spectral density function of i-th kind of useful component is xi, the spectrum energy of this useful component and score
The ratio of energy is:
Y=∫ xidf/{ ∫ x1df+ ∫ x2df+ ... ∫ xndf}, f are spectral frequency
Y is differentiated, dy/dv={ ∫ xidf/ [∫ x1df+ ∫ x2df+ ... ∫ xndf] }/dv
Make dy/dv=0, draw best execution speed,
Heterogeneity affect difference need weight to consider in the case of, the ratio of the spectrum energy of this useful component and total spectrum energy is then
For:
Y=∫ xidf/{k1* ∫ x1df+k2* ∫ x2df+ ... kn* ∫ xndf}, wherein k1, k2 ... kn is weight coefficient, other formula are not
Become.
3. blood-taking device as claimed in claim 1 or 2, it is characterised in that also including feeding back unit, described feedback unit is provided with
Feeding back blood pump, the import of described feedback blood pump connects the output channel that should feed back blood constituent of described seperator, described feedback
Blood delivery side of pump is connected with feedback pipe, and in blood collection procedure and/or after blood drawing finishes, the control of described central control unit is described
Blood drawing blood pump quits work, and then controls described feedback blood pump work.
4. blood-taking device as claimed in claim 3, it is characterised in that also including fluid infusion unit, described fluid infusion unit is provided with fluid infusion
Blood pump, described fluid infusion blood pump is provided with feed tube and liquid supplementation pipe, and when needs are to blood donor's fluid infusion, described central control unit controls
Described blood drawing blood pump quits work, and then controls the work of fluid infusion blood pump.
5. blood-taking device as claimed in claim 4, it is characterised in that described liquid supplementation pipe and feedback pipe are connected to same input
Managing, described input pipe is furnished with ultrasonic bubble and pressure-detecting device for detecting bubble information and pressure information in pipe, and will
Corresponding detection information reaches described central control unit by wiredly and/or wirelessly mode, and described central control unit is to coming
It is analyzed from the detection information of described input pipe ultrasonic bubble and pressure-detecting device, when there is bubble in described input pipe
When, the described fluid infusion blood pump of described central control unit control or feedback blood pump quit work.
6. blood-taking device as claimed in claim 5, it is characterised in that described memory cell is provided with for detecting described required blood
The storage liquid level supersonic detection device of liquid level information in the storage container of liquid composition, described storage liquid level supersonic detection device is by phase
The detection information answered reaches described central control unit by wiredly and/or wirelessly mode, described central control unit to from
The detection information of described storage liquid level supersonic detection device is analyzed, when liquid level in the storage container of described desired blood component
When reaching setting height, described central control unit control described blood drawing blood pump quits work.
7. blood-taking device as claimed in claim 6, it is characterised in that the real-time noninvasive detection device of described internal blood constituent is
At least can the internal blood constituent real-time Non-invasive detection dress of one of red blood cell, blood plasma and PC in blood in detection body
Putting, described blood separated component real-time detection apparatus is the real-time detection apparatus that at least can detect blood platelet purity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6064898A (en) * | 1998-09-21 | 2000-05-16 | Essential Medical Devices | Non-invasive blood component analyzer |
| CN1356146A (en) * | 2000-11-28 | 2002-07-03 | 泰尔茂株式会社 | Thrombocyte sampling device |
| JP2006034467A (en) * | 2004-07-23 | 2006-02-09 | Terumo Corp | Filter monitoring system and platelet sampling device |
| JP2007130283A (en) * | 2005-11-11 | 2007-05-31 | Terumo Corp | Blood component sampling device |
| CN203074709U (en) * | 2012-05-07 | 2013-07-24 | 天津恒基晟达科技有限公司 | Human body blood component non-invasive monitoring device based on time gate |
| CN203885906U (en) * | 2014-05-19 | 2014-10-22 | 四川南格尔生物科技有限公司 | Single-pump centrifugal blood collection and liquid supplement device |
-
2014
- 2014-10-28 CN CN201410583668.3A patent/CN104288854B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6064898A (en) * | 1998-09-21 | 2000-05-16 | Essential Medical Devices | Non-invasive blood component analyzer |
| CN1356146A (en) * | 2000-11-28 | 2002-07-03 | 泰尔茂株式会社 | Thrombocyte sampling device |
| JP2006034467A (en) * | 2004-07-23 | 2006-02-09 | Terumo Corp | Filter monitoring system and platelet sampling device |
| JP2007130283A (en) * | 2005-11-11 | 2007-05-31 | Terumo Corp | Blood component sampling device |
| CN203074709U (en) * | 2012-05-07 | 2013-07-24 | 天津恒基晟达科技有限公司 | Human body blood component non-invasive monitoring device based on time gate |
| CN203885906U (en) * | 2014-05-19 | 2014-10-22 | 四川南格尔生物科技有限公司 | Single-pump centrifugal blood collection and liquid supplement device |
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