CN104288854A - Method and device for high-precision closed-loop blood constituent real-time separation blood sampling - Google Patents
Method and device for high-precision closed-loop blood constituent real-time separation blood sampling Download PDFInfo
- Publication number
- CN104288854A CN104288854A CN201410583668.3A CN201410583668A CN104288854A CN 104288854 A CN104288854 A CN 104288854A CN 201410583668 A CN201410583668 A CN 201410583668A CN 104288854 A CN104288854 A CN 104288854A
- Authority
- CN
- China
- Prior art keywords
- blood
- real
- constituent
- time
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
- A61M1/382—Optimisation of blood component yield
- A61M1/385—Optimisation of blood component yield taking into account of the patient characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/005—Anatomical parts of the body used as an access side to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
Abstract
The invention relates to a method and device for high-precision closed-loop blood constituent real-time separation blood sampling. The method includes the steps that the blood drawn from the body of a blood donor is separated in real time, blood constituents which should be infused back are infused back to the body of the blood donor in a field, the required blood constituents are stored in a corresponding required blood constituent container, indexes of the blood constituents in the body of the blood donor are detected in real time in a non-invasive mode in the blood drawing process, blood sampling is stopped when the indexes of the blood constituents in the body of the blood donor are reduced below safety threshold values, the separated blood constituents are detected in real time so that the operation speed of a blood centrifugal machine can be controlled according to a detection result, and the optimal separation effect is achieved. The device for high-precision closed-loop blood constituent real-time separation blood sampling comprises a blood drawing unit, a blood separation unit, a storage unit, a back infusion unit, a constituent quality detection unit, a fluid infusion unit, a real-time physiological monitoring unit and a central processing unit. According to the method and device, on the premise that safety is guaranteed, the maximum blood donation volume can be accurately determined according to physical indexes of the blood donor, and the blood separation quality can be improved and guaranteed.
Description
Technical field
The present invention relates to a kind of high precision closed loop blood constituent and be separated blood-sampling method and blood-taking device in real time.
Background technology
Existing blood-taking device is generally blood drawing blood pump and corresponding storage blood bag, blood is extracted out by bloodletting tube and blood drawing syringe needle by blood drawing blood pump in human body, send into storage blood bag to store, what gather due to this mode is whole blood, actual needs may be then part useful component in blood, development plays a kind of novel separation Blood collection thus, the equipment mainly blood separator of taking a blood sample is carried out by blood separation technology, after the separation of whole blood of employing, unwanted composition (such as blood plasma) feeds back in blood donor's body, reducing thus donates blood to the adverse effect of blood donor, and improve blood utilize effect, there is following defect in existing this technology: one is the maximum amount of donating blood cannot determining blood donor exactly, once maximum blood sampling volume often controls a relatively conservative level, be unfavorable for maximally utilising when ensureing safety resource of donating blood, particularly for some special blood, owing to donating blood, source is considerably less, be easy to the phenomenon occurring inadequate blood source, and for autologous feedback, then be difficult to especially obtain enough feedback blood volumes from patient, two is that blood separator only has open loop, metered dose, separated component is not detected in real time in separation process, disintegrate-quality is difficult to control.
Summary of the invention
For object of the present invention overcomes the above-mentioned defect of prior art, provide a kind of high precision closed loop blood constituent and be separated blood-sampling method and blood-taking device in real time, so that under the premise that security is guaranteed, according to the physical signs of blood donor, determine the maximum amount of donating blood exactly.
Further aim of the present invention detects in real time the blood constituent be separated, and by feedback control, improves and ensure disintegrate-quality.
The technical solution adopted in the present invention is:
A kind of high precision closed loop blood constituent is separated blood-sampling method in real time, it is separated in real time to the blood extracted in blood donor's body, be separated into different blood constituents, described different blood constituent comprises should feed back blood constituent and one or more desired blood components, should feed back blood constituent (do not need gather and the blood constituent that should feed back in blood donor's body) scene feeds back in blood donor's body, desired blood component is stored in corresponding desired blood component container, extracting in the process of blood in blood donor's body, blood constituent index in real-time Non-invasive detection blood donor body, with the blood constituent index in blood donor's body (such as, the concentration index of one or more blood constituents) as the individual index limiting maximum blood sampling volume, when the blood constituent index in blood donor's body drops to safe gate value (lower threshold), stop blood sampling.In addition, except the present invention is according to except blood donor's physiologic information maximum blood sampling volume that particularly body inner blood composition detection information is determined, in blood sampling, also should the situation of blood sampling be stopped to detect accordingly and judge according to existing other standards and specification (if any) correspondence simultaneously, when occurring that any one should stop the situation of taking a blood sample, blood sampling all should be stopped according to corresponding standards and norms.
Preferably, the blood constituent in separation and/or after being separated is detected in real time, according to Detection Information, online real-time feedback control is carried out to blood separating mechanism, regulate the speed of service of the centrifugal blood seperator being used for blood separation, to reach optimal separation effect.
Preferably, when described desired blood component comprises platelet, the real-time detection of the blood constituent in described separation and/or after being separated at least comprises the hematoblastic purity detecting in separation and/or after being separated.
Preferably, the algorithm of the blood constituent index in described real-time Non-invasive detection blood donor body adopts dynamic spectrum integration to dissolve equation with many unknowns method from normalizing, m spectral frequency f1, f2...fm is provided with in full spectral range of analysis, corresponding spectral power is p1, p2...pm, to i-th power spectrum pi respectively at 0-fdc (as 0.5Hz) and fac1 (as 0.5Hz)-fac2 (as 25Hz) integration, be respectively pidc and piac
pidc＝∫?pidf?f∈(0-fdc)
piac＝∫?pidf?f∈(fac1-fac2)
For noisy dynamic spectrum integration, then the piac limit of integration selects the half-power region of pulse Spectral structure:
Piac=∫ pidf f ∈ (f0.51-f0.5h), in formula, f0.51, f0.5h are respectively upper and lower half power points,
Get both log ratio ln (piac)/ln (pidc)=ri, column matrix equation:
I-th kind of composition Ci=a1*r1+a2*r2+...+an*rn
Separate n equation and obtain composition ci.
Preferably, the described algorithm carrying out detecting in real time to the blood constituent in separation and/or after being separated adopts spectrum integral proportionality coefficient method, and the automatic speed of service controlling centrifugal blood seperator system, reaches the object of control accuracy, be specially:
If there is n kind composition in blood, x1, x2......xn are the spectral density function of various composition, when system operates, spectral density is relevant with running speed v, if the spectral density function of i-th kind of useful component (as hemoglobin) is xi, the spectrum energy of this useful component with the ratio of total spectrum energy is:
Y=∫ xidf/{ ∫ x1df+ ∫ x2df+... ∫ xndf}, f is spectral frequency
Y is differentiated, dy/dv={ ∫ xidf/ [∫ x1df+ ∫ x2df+... ∫ xndf] }/dv
Make dy/dv=0, draw best execution speed,
When heterogeneity impact difference needs weight to consider, the spectrum energy of this useful component with the ratio of total spectrum energy is then:
Y=∫ xidf/{k1* ∫ x1df+k2* ∫ x2df+...kn* ∫ xndf}, wherein k1, k2...kn are weight coefficient, and other formula are constant.
A kind of high precision closed loop blood constituent is separated blood-taking device in real time, and it adopts any one method above-mentioned, comprising:
Blood drawing unit, be provided with blood drawing blood pump, described blood drawing blood pump is provided with bloodletting tube;
Blood separation unit, be provided with the seperator for separating of blood constituent, the preferred centrifugal blood seperator of described seperator, the import of described seperator connects the output of described blood drawing blood pump, component separating is carried out to the blood from described blood drawing blood pump, be provided with multiple output channel for exporting different blood constituent, such as comprise one for exporting the output channel and one or more output channel for exporting desired blood component that should feed back blood constituent, when desired blood component is multiple, different blood constituents exports respectively by different blood constituent output channels,
Memory element, be provided with the storage container of one or more storage blood pump and one or more desired blood components supporting with described one or more storage blood pump, such as store up blood bag, the import of described storage blood pump connects the output channel of the corresponding blood constituent of described seperator, and described storage blood delivery side of pump connects the storage container of corresponding desired blood component;
Real-time physiological monitoring unit, for Real-time Collection blood donor physiologic information, at least comprise the real-time noninvasive detection device of body inner blood composition, the real-time noninvasive detection device of described body inner blood composition is provided with signal transmission cable and/or wireless communication module, for communicating to connect with central control unit;
Central control unit, form primarily of middle control computer or middle control data processor, for controlling the work of blood drawing blood pump, to extract blood in blood donor's body, receive the blood donor's physiologic information from described physiology monitoring unit and analyse and compare, when blood donor's physical signs drops to blood drawing safe gate value (lower threshold) or when the blood constituent of collection reaches the amount of setting, control blood drawing blood pump to quit work, described blood donor's information at least comprises the body inner blood component target information of the blood donor that the real-time noninvasive detection device of described body inner blood composition obtains.
Preferably, this device also comprises composition quality detecting unit, described composition quality detecting unit is provided with blood separation composition real-time detection apparatus, detect in real time for newly separating the blood constituent of (comprising in separation process and/or after being separated) to described seperator, corresponding Detection Information is reached described CPU by wired and/or wireless mode by described blood separation composition real-time detection apparatus, the Detection Information of described CPU to described blood separation composition real-time detection apparatus is analyzed, the running parameter of described seperator is controlled (such as according to analysis result, when described seperator adopts blood separator, adjustment is separated rotating speed, to obtain required separated component purity).
Preferably, this device also comprises feedback unit, described feedback unit is provided with feedback blood pump, the import of described feedback blood pump connects the output channel that should feed back blood constituent of described seperator, described feedback blood delivery side of pump is connected with and feeds back pipe, and in blood collection procedure and/or after blood drawing, described central control unit controls described blood drawing blood pump and quits work, then control the work of described feedback blood pump, so as described seperator to be separated should feed back blood components reinfusion in blood donor's body.
Preferably, this device also comprises fluid infusion unit, described fluid infusion unit is provided with fluid infusion blood pump, described fluid infusion blood pump is provided with feed tube and liquid supplementation pipe, when needs are to blood donor's fluid infusion, described central control unit controls described blood drawing blood pump and quits work, then the work of fluid infusion blood pump is controlled, fluid infusion liquid is sent in blood donor's body, can connecting by described feed tube the bag (or bottle etc.) that fluid infusion liquid is housed and carry out fluid infusion, drug injection can also be carried out by preparing required medicine in bottle by fluid infusion blood pump.
Preferably, described liquid supplementation pipe and feedback pipe are connected to same input pipe, described input pipe is furnished with the ultrasonic bubble/pressure-detecting device for bubble information in detector tube and pressure information, corresponding Detection Information is reached described CPU by wired and/or wireless mode by described ultrasonic bubble/pressure-detecting device, described CPU is analyzed the Detection Information from described input pipe ultrasonic bubble/pressure-detecting device, when there is bubble in described input pipe, fluid infusion blood pump described in described central processing unit controls or feedback blood pump quit work.
Preferably, described memory element is provided with the storage liquid level supersonic detection device of liquid level information in the storage container for detecting described desired blood component, corresponding Detection Information is reached described CPU by wired and/or wireless mode by described storage liquid level supersonic detection device, described CPU is analyzed the Detection Information from described storage liquid level supersonic detection device, when in the storage container of described desired blood component, liquid level reaches setting height, blood pump of drawing blood described in described central processing unit controls quits work.
Preferably, the real-time noninvasive detection device of described body inner blood composition is at least can erythrocyte in detection bodies inner blood, one of blood plasma and PC (cell, any one index in blood plasma and PC) the real-time noninvasive detection device of body inner blood composition, various suitable Non-invasive detection technology can be adopted, such as, by selecting finger or other appropriate site of health of the infrared ray radiation blood donor of appropriate frequency/frequency range, detect transmitted spectrum, utilize the ultrared Absorption of heterogeneity to different frequency different, by analyzing the infrared ray absorbing situation to characteristic frequency/frequency range, analyze the concentration of corresponding composition in blood.
Preferably, described blood separation composition real-time detection apparatus is the real-time detection apparatus that at least can detect platelet purity, various suitable detection technique can be adopted, such as be suitable for hematoblastic special materials detection technique and spectrum detection device, for the online real-time feedback control of platelet purity, thus promote platelet purity and quality.
Beneficial effect of the present invention: due to the blood constituent index in real-time Non-invasive detection blood donor body, and stop blood drawing dropping to safe gate value when blood constituent index in blood donor's body, for determining that maximum blood sampling volume provides the foundation of science, thus achieve the accurate control to maximum blood sampling volume, particularly nervous in blood source and other in particular cases, be conducive to making full use of resource of donating blood; Due to the real-time detection to blood separation, by the mode of feedback control, segregation apparatus is controlled, be conducive to improving disintegrate-quality; Owing to providing the suitable algorithm relating to and controlling blood donor's body inner blood component target and disintegrate-quality, be conducive to realizing corresponding detection and control object, ensure detection and control quality.
Accompanying drawing explanation
Fig. 1 is system architecture diagram of the present invention.
Detailed description of the invention
See Fig. 1, the execution part of this device mainly comprises: blood drawing unit, blood separation unit, memory element, feed back unit and fluid infusion unit, these perform part (unit) and carry out under the control of the central processing unit draw blood (collection whole blood), blood separation, the storage of desired blood component, feedback and fluid infusion (the such as nutritional solution and medicinal liquid if desired of blood constituent should be fed back, determine according to actual needs), central control unit is analyzed the information obtained from the real-time noninvasive detection device of body inner blood composition in real-time physiological monitoring unit and the blood separation composition real-time detection apparatus in composition quality detecting unit, and according to corresponding working specification etc., control the blood drawing blood pump of blood drawing unit, the seperator of blood separation unit, the storage blood pump of memory element, feed back the feedback blood pump of unit and the fluid infusion blood pump work of fluid infusion unit, realize blood drawing, be separated, store, the functions such as feedback and fluid infusion.Wherein,
Blood drawing unit, for gathering whole blood.
Blood separation unit, is mainly separated from each other the separation of blood constituent in whole blood the blood plasma in blood, erythrocyte and platelet for realizing.
Real-time physiological monitoring unit, for feeding back to CPU the monitoring of blood donor's physiologic information in the process of donating blood, be mainly used for the Non-invasive detection to body inner blood composition, also the collection to other physiologic informations of blood donor can be comprised according to actual needs, such as in blood sampling, erythrocyte quantity in dynamic Non-invasive detection body, sets up specialist system operational model, under the oxygen delivery capacity ensureing body tissue, reduce blood sampling time and number of times as far as possible.
Feed back unit and fluid infusion unit: CPU is according to blood constituent Non-invasive detection information dynamic in body, dynamic calculation fluid infusion composition and consumption, by feeding back unit and fluid infusion unit should feed back blood constituent respectively and fluid infusion liquid inputs human body, reach the target of safety blood taking.
The work process of this device is:
First detect by controlling the body inner blood composition of the real-time noninvasive detection device of data processor (computer) instruction body inner blood composition to blood donor in CPU, determine whether body inner blood component target is in safety range, if safety, then instruction unpack blood drawing pump starts blood drawing, can often take out 10ml blood, the blood constituent of a Non-invasive detection blood donor detects.Blood enters blood separation unit from blood drawing syringe needle through blood drawing blood pump, blood separation unit by centrifuge by blood separation, the blood separation composition real-time detection apparatus (testing circuit) of described composition quality detecting unit detects in real time to isolated blood constituent, preferably just isolated (newly isolated) blood constituent is detected, to feed back timely, in the conceived case, preferably detect to the isolated blood constituent being positioned at described seperator inside, also can the blood constituent in the output channel of the corresponding blood constituent of described seperator be detected, test point is preferably closely away from the position of seperator, according to the setting of seperator, result inputted the automatic control unit of centrifuge after CPU analyzing and processing or directly corresponding Detection Information analyzed by the automatic control unit of blood separation composition real-time detection apparatus and/or centrifuge, by the speed of service of the automatic control unit adjustment centrifuge of centrifuge, reach optimal separation precision, after being separated, various desired blood component is stored in different storage blood bag by different output channels under the effect storing blood pump, after being separated, unwanted composition (should feed back blood constituent) access feeds back blood pump, computer instruction blood drawing pump stops, start to feed back blood pump and open outlet tube ultrasonic bubble checkout gear (testing circuit) simultaneously and carry out bubble, should feed back in blood components reinfusion blood donor body.
Blood drawing is stopped when the collection capacity that the desired blood component obtained meets setting or the physical signs that is checked through blood donor drop to Secure Threshold.
When blood donor needs complementary medicine, computer instruction blood drawing blood pump 1 and feedback blood pump stop, and open fluid infusion blood pump infused drug.
Described various blood pump all adopts accurate blood transfusion apparatus.
Various unit of the present invention, except having of clearly recording is main and/or except the part/device of basic function, various part/device supporting and/or attached accordingly can also be comprised, have such as the installation component of the device of main or basic function, described in have the device of main and/or basic function supporting control circuit, for realizing the connection tube or other forms of connecting pipe etc. of liquid transfer, these supporting and/or attached part/devices can according to existing techniques in realizing.
The connection that the present invention relates to for transmitting blood or blood constituent can adopt various suitable pipeline to connect, the described pipeline for connecting can be rubber tube, plastic tube and metal tube etc., and various required conduit coupling can be provided with, the described pipeline for connecting can be provided with or not be provided with the temporarily providing room/temporary container of liquid.
The mechanical package of each unit of the present invention or integrated can according to prior art.
Described central control unit can according to prior art for controlling the hardware structure of each blood pump and seperator and/or communication mode, can for connecting the control interface of each blood pump and separator respectively by controlling cable.
Alleged and the central control unit of the present invention communicates to connect or relates to the information/data transmission between central control unit, for control computer in direct or indirect mode and described central control unit or middle control data processor communicate to connect or and described central control unit in information/data transmission between control computer or middle control data processor, described middle control computer or middle control data processor can be provided with corresponding interface circuit or data converting circuit etc., communication connection described in realization or information/data transmission, described communication mode and information/data load mode and corresponding hardware structure can according to prior aries.
The present invention according to prior art, can arrange various display, warning and output/input device.
Each optimization technique means disclosed by the invention, unless otherwise indicated and optimization technique means be outside the further restriction of another technological means, all can combination in any, form some different technical schemes.
Claims (10)
1. a high precision closed loop blood constituent is separated blood-sampling method in real time, it is separated in real time to the blood extracted in blood donor's body, be separated into different blood constituents, described different blood constituent comprises should feed back blood constituent and one or more desired blood components, should feed back blood constituent scene feeds back in blood donor's body, desired blood component is stored in corresponding desired blood component container, extracting in the process of blood in blood donor's body, blood constituent index in real-time Non-invasive detection blood donor body, using the blood constituent index in blood donor's body as the individual index limiting maximum blood sampling volume, when the blood constituent index in blood donor's body drops to safe gate value, stop blood sampling.
2. blood-sampling method as claimed in claim 1, it is characterized in that detecting in real time the blood constituent in separation and/or after being separated, according to Detection Information, online real-time feedback control is carried out to blood separating mechanism, regulate the speed of service of the centrifugal blood seperator being used for blood separation, to reach optimal separation effect.Such as: when described desired blood component comprises platelet, the real-time detection of the blood constituent in described separation and/or after being separated at least comprises the hematoblastic purity detecting in separation and/or after being separated.
3. blood-sampling method as claimed in claim 2, is characterized in that:
The algorithm of the blood constituent index in described real-time Non-invasive detection blood donor body adopts dynamic spectrum integration to dissolve equation with many unknowns method from normalizing, m spectral frequency f1, f2...fm is provided with in full spectral range of analysis, corresponding spectral power is p1, p2...pm, to i-th power spectrum pi respectively at 0-fdc (as 0.5Hz) and fac1 (as 0.5Hz)-fac2 (as 25Hz) integration, be respectively pi dc and pi ac
pidc＝∫?pidf?f∈(0-fdc)
piac＝∫?pidf?f∈(fac1-fac2)
For noisy dynamic spectrum integration, then the piac limit of integration selects the half-power region of pulse Spectral structure:
Piac=∫ pi df f ∈ (f0.51-f0.5h), in formula, f0.51, f0.5h are respectively upper and lower half power points,
Get both log ratio ln (piac)/ln (pidc)=ri, column matrix equation:
I-th kind of composition Ci=a1*r1+a2*r2+...+an*rn
Separate n equation and obtain composition ci,
The described algorithm carrying out detecting in real time to the blood constituent in separation and/or after being separated adopts spectrum integral proportionality coefficient method, and the automatic speed of service controlling centrifugal blood seperator system, reaches the object of control accuracy, be specially:
If there is n kind composition in blood, x1, x2......xn are the spectral density function of various composition, when system operates, spectral density is relevant with running speed v, if the spectral density function of i-th kind of useful component (as hemoglobin) is xi, the spectrum energy of this useful component with the ratio of total spectrum energy is:
Y=∫ xidf/{ ∫ x1df+ ∫ x2df+... ∫ xndf}, f is spectral frequency
Y is differentiated, dy/dv={ ∫ xidf/ [∫ x1df+ ∫ x2df+... ∫ xndf] }/dv
Make dy/dv=0, draw best execution speed,
When heterogeneity impact difference needs weight to consider, the spectrum energy of this useful component with the ratio of total spectrum energy is then:
Y=∫ xidf/{k1* ∫ x1df+k2* ∫ x2df+...kn* ∫ xndf}, wherein k1, k2...kn are weight coefficient, and other formula are constant.
4. adopt the high precision closed loop blood constituent of method described in any one claim in claim 1-3 to be separated a blood-taking device in real time, it is characterized in that comprising:
Blood drawing unit, be provided with blood drawing blood pump, described blood drawing blood pump is provided with bloodletting tube;
Blood separation unit, is provided with the seperator for separating of blood constituent, and the preferred centrifugal blood seperator of described seperator, carries out component separating to the blood from described blood drawing blood pump, is provided with multiple output channel for exporting different blood constituent;
Memory element, be provided with the storage container of one or more storage blood pump and one or more desired blood components supporting with described one or more storage blood pump, the import of described storage blood pump connects the output channel of the corresponding blood constituent of described seperator, and described storage blood delivery side of pump connects the storage container of corresponding desired blood component;
Real-time physiological monitoring unit, for Real-time Collection blood donor physiologic information, at least comprise the real-time noninvasive detection device of body inner blood composition, the real-time noninvasive detection device of described body inner blood composition is provided with signal transmission cable and/or wireless communication module, for communicating to connect with described central control unit;
Central control unit, form primarily of middle control computer or middle control data processor, for controlling the work of blood drawing blood pump, receive the blood donor's physiologic information from described physiology monitoring unit and analyse and compare, when blood donor's physical signs drops to blood drawing safe gate value (lower threshold) or when the blood constituent of collection reaches the amount of setting, control blood drawing blood pump to quit work, described blood donor's information at least comprises the body inner blood component target information of the blood donor that the real-time noninvasive detection device of described body inner blood composition obtains.
5. blood-taking device as claimed in claim 4, characterized by further comprising composition quality detecting unit, described composition quality detecting unit is provided with blood separation composition real-time detection apparatus, blood constituent for newly separating described seperator detects in real time, corresponding Detection Information is reached described CPU by wired and/or wireless mode by described blood separation composition real-time detection apparatus, the Detection Information of described CPU to described blood separation composition real-time detection apparatus is analyzed, the running parameter of described seperator is controlled according to analysis result.
6. the blood-taking device as described in claim 4 or 5, characterized by further comprising feedback unit, described feedback unit is provided with feedback blood pump, the import of described feedback blood pump connects the output channel that should feed back blood constituent of described seperator, described feedback blood delivery side of pump is connected with and feeds back pipe, in blood collection procedure and/or after blood drawing, described central control unit controls described blood drawing blood pump and quits work, and then controls the work of described feedback blood pump.
7. blood-taking device as claimed in claim 6, characterized by further comprising fluid infusion unit, described fluid infusion unit is provided with fluid infusion blood pump, described fluid infusion blood pump is provided with feed tube and liquid supplementation pipe, when needs are to blood donor's fluid infusion, described central control unit controls described blood drawing blood pump and quits work, and then controls the work of fluid infusion blood pump.
8. blood-taking device as claimed in claim 7, it is characterized in that described liquid supplementation pipe and feed back pipe being connected to same input pipe, described input pipe is furnished with the ultrasonic bubble/pressure-detecting device for bubble information in detector tube and pressure information, and corresponding Detection Information is reached described CPU by wired and/or wireless mode, described CPU is analyzed the Detection Information from described input pipe ultrasonic bubble/pressure-detecting device, when there is bubble in described input pipe, fluid infusion blood pump described in described central processing unit controls or feedback blood pump quit work.
9. blood-taking device as claimed in claim 8, it is characterized in that the storage liquid level supersonic detection device of liquid level information in the storage container that described memory element is provided with for detecting described desired blood component, corresponding Detection Information is reached described CPU by wired and/or wireless mode by described storage liquid level supersonic detection device, described CPU is analyzed the Detection Information from described storage liquid level supersonic detection device, when in the storage container of described desired blood component, liquid level reaches setting height, blood pump of drawing blood described in described central processing unit controls quits work.
10. blood-taking device as claimed in claim 9, it is characterized in that the real-time noninvasive detection device of described body inner blood composition is at least can the real-time noninvasive detection device of body inner blood composition of erythrocyte, one of blood plasma and PC in detection bodies inner blood, described blood separation composition real-time detection apparatus is the real-time detection apparatus that at least can detect platelet purity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410583668.3A CN104288854B (en) | 2014-10-28 | 2014-10-28 | High precision closed loop blood constituent separates blood-sampling method and blood-taking device in real time |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410583668.3A CN104288854B (en) | 2014-10-28 | 2014-10-28 | High precision closed loop blood constituent separates blood-sampling method and blood-taking device in real time |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104288854A true CN104288854A (en) | 2015-01-21 |
| CN104288854B CN104288854B (en) | 2016-11-09 |
Family
ID=52308955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410583668.3A Active CN104288854B (en) | 2014-10-28 | 2014-10-28 | High precision closed loop blood constituent separates blood-sampling method and blood-taking device in real time |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104288854B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245727A (en) * | 2018-03-16 | 2018-07-06 | 柴琳 | Blood refluxing device and feedback method more than heart lung machine |
| WO2020238150A1 (en) * | 2019-05-29 | 2020-12-03 | 刘忠英 | In-vivo closed-loop sterilization apparatus |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6064898A (en) * | 1998-09-21 | 2000-05-16 | Essential Medical Devices | Non-invasive blood component analyzer |
| CN1356146A (en) * | 2000-11-28 | 2002-07-03 | 泰尔茂株式会社 | Thrombocyte sampling device |
| JP2006034467A (en) * | 2004-07-23 | 2006-02-09 | Terumo Corp | Filter monitoring system and platelet sampling device |
| JP2007130283A (en) * | 2005-11-11 | 2007-05-31 | Terumo Corp | Blood component sampling device |
| CN203074709U (en) * | 2012-05-07 | 2013-07-24 | 天津恒基晟达科技有限公司 | Human body blood component non-invasive monitoring device based on time gate |
| CN203885906U (en) * | 2014-05-19 | 2014-10-22 | 四川南格尔生物科技有限公司 | Single-pump centrifugal blood collection and liquid supplement device |
-
2014
- 2014-10-28 CN CN201410583668.3A patent/CN104288854B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6064898A (en) * | 1998-09-21 | 2000-05-16 | Essential Medical Devices | Non-invasive blood component analyzer |
| CN1356146A (en) * | 2000-11-28 | 2002-07-03 | 泰尔茂株式会社 | Thrombocyte sampling device |
| JP2006034467A (en) * | 2004-07-23 | 2006-02-09 | Terumo Corp | Filter monitoring system and platelet sampling device |
| JP2007130283A (en) * | 2005-11-11 | 2007-05-31 | Terumo Corp | Blood component sampling device |
| CN203074709U (en) * | 2012-05-07 | 2013-07-24 | 天津恒基晟达科技有限公司 | Human body blood component non-invasive monitoring device based on time gate |
| CN203885906U (en) * | 2014-05-19 | 2014-10-22 | 四川南格尔生物科技有限公司 | Single-pump centrifugal blood collection and liquid supplement device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245727A (en) * | 2018-03-16 | 2018-07-06 | 柴琳 | Blood refluxing device and feedback method more than heart lung machine |
| WO2020238150A1 (en) * | 2019-05-29 | 2020-12-03 | 刘忠英 | In-vivo closed-loop sterilization apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104288854B (en) | 2016-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102046223B (en) | System and method for plasma reduced platelet collection | |
| EP2495302B1 (en) | Bio-device for extracting hematopoietic stem cells and mesenchymal stem cells in peripheral blood | |
| CN102395392B (en) | System and method for the re-anticoagulation of platelet rich plasma | |
| CN202289094U (en) | Transfusion alarm | |
| CN204275126U (en) | High precision closed loop blood constituent is separated blood-taking device in real time | |
| RU2013145427A (en) | PREPARING ANTICOAGULANT BLOOD COLLECTION LINE | |
| CN104491945B (en) | A kind of sampled plasma device | |
| CN102048546A (en) | System for monitoring, collecting and detecting biological information of human blood in real time | |
| CN104288854A (en) | Method and device for high-precision closed-loop blood constituent real-time separation blood sampling | |
| CN204352269U (en) | A kind of sampled plasma device | |
| CN103830783A (en) | Extracorporeal circulation perfusion policy making system | |
| CN103619377A (en) | Dermally affixed device for intravenous access | |
| CN102058914A (en) | Intelligent infusion apparatus with flow stabilizing and bubble breaking device and control method thereof | |
| CN107812276A (en) | Infusion flow rate monitoring and control system and method based on RFID technique | |
| CN104215474A (en) | Two-pipe saliva sampling device | |
| CN207520722U (en) | A kind of blood plasma extraction element | |
| CN201658692U (en) | Artificial pancreas system | |
| CN102160777B (en) | Body fluid bioinformation fiber dynamic testing system | |
| CN105498010B (en) | Full-automatic whole blood collecting and separating device and method | |
| CN211096685U (en) | Infusion dripping speed detection device | |
| CN107167216B (en) | It is a kind of to detect accurate blood plasma and haemocyte interface identification device | |
| CN203852650U (en) | Single-pump centrifugal erythrocyte removal and collection device | |
| CN203059677U (en) | Volume monitoring instrument | |
| CN205460112U (en) | Separator is gathered to full -automatic whole blood | |
| CN203943964U (en) | A kind of transfusion device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |