CN104096313A - Implantable nerve electrical stimulation device and system - Google Patents
Implantable nerve electrical stimulation device and system Download PDFInfo
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- CN104096313A CN104096313A CN201410270731.8A CN201410270731A CN104096313A CN 104096313 A CN104096313 A CN 104096313A CN 201410270731 A CN201410270731 A CN 201410270731A CN 104096313 A CN104096313 A CN 104096313A
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Abstract
The invention discloses an implantable nerve electrical stimulation device which comprises a personal digital assistant (PDA), an in vitro controller, an in vivo stimulator and a stimulation electrode. A user uses the PDA to record the information of an experiment animal, and the working condition of the in vivo stimulator and the stimulation electrode. Stimulation parameters are programmed and are transmitted to the in vitro controller through bidirectional wireless radio frequency communication. Data and energy percutaneous wireless transmission is carried out between the in vitro controller and the in vivo stimulator through in vitro and in vivo coil coupling. The in vivo stimulator is sealed by a biology compatible silicone material, produces a stimulation pulse with specific parameters, and outputs the stimulation pulse to the stimulation electrode which is implanted into an epidural space through operation, so as to carry out spinal cord nerve electrical stimulation. The stimulation electrode is a multi-contact electrode based on a flexible circuit board technology. Insulation package is carried out on a number of gold-plated electrode contacts through polyimide. The device and the system, which are provided by the invention, are used for analgesia and promoting the mechanism study of movement function recovery after spinal cord injury, and can be used for the animal experiment study of the electrical stimulation therapy of Parkinson and other neurological diseases.
Description
Technical field
The invention belongs to implantable nerve prosthese technical field, more specifically, relate to a kind of implantable neural electrical stimulation equipment and system.
Background technology
Epidural spinal cord stimulation trial (epidural spinal cord stimulation, ESCS) refer to by operation electrode is implanted after spinal cord epidural space dorsal part, electrostimulator produces the boost pulse of special parameter by electrode stimulating myeloid tissue, reaches the object of test-and-treat.Since late 1970s, ESCS has established immeasurable critical role in intractable pain treatment field, except analgesia, the diagnosis, the inhibition that are also developed for nervous system disease are trembled and promote motor function recovery, especially for incomplete spinal cord injury (incomplete spinal cord injury, ISCI) patient's walking function recovers there is positive therapeutic effect with reconstruction, in recent years becomes the study hotspot of nervous system and rehabilitation engineering.
The implantable neural electrical stimulation device of clinical practice is at present mainly by Medtronic, Boston Scientific, the companies such as St.Jude Medical provide, but these products are mainly used in analgesia, its stimulus parameter adjusting range can not meet the demand of motion function rehabilitation after spinal cord injury, and because ESCS is for easing pain and promoting that the mechanism of motor function recovery is still not clear at present after spinal cord injury, in the urgent need to illustrate the neuromechanism of this therapy by animal experiment study, instruct clinical practice, but existing implanted stimulator product at all can not be for the Operation of minitype animal experiment (as rat etc.), simultaneously expensive, be not suitable for zoopery, therefore for zooperal implantable epidural spinal cord stimulation trial device, be a blank at present.
" a kind of implantable nerve electric pulse stimulation system " described in Chinese invention patent ZL200510116704.6 consists of the pulse generator in implant into body, lead electrode, vitro program controlled device, palm PC (PDA), controlling magnet.This consists external magnet, vitro program controlled device and PDA realize Untouched control duty and regulating impulse parameter, produce the adjustable electric stimulation pulses of parameter such as amplitude, frequency, pulsewidth, by stimulating electrode, target area is realized to electricity irritation, thereby find best electronic stimulation parameter; Also the software of internal controller can be upgraded by PDA and program controller, thereby also the update of product software can be realized without operation.This stimulating apparatus utilizes the magnetic coupling percutaneous between receiving coil in external transmitting coil and body to transmit data, but its communication distance is short, rate of data signalling is low.This stimulating apparatus implants and exists running down of battery to need the problem of second operation, and is not for zoopery, to design specially, is not suitable for zoopery.
" implanted type programmable nervus stimulator " described in Chinese invention patent ZL200610025658 has wireless messages and power transfer function, comprise communication unit, processing and control element (PCE) and electrode drive unit, communication unit is connected with external controller by wireless radio frequency mode, connect and process control section thereafter, after processing controls part, connection electrode drive part is with driving electrode array, communications portion is processed the energy importing into by wireless radio frequency mode and information, processing controls is partly used FPGA to realize the decoding to afferent message, information distribution and transfer control, the control of electrode drive circuit and the control of power supply, electrode drive is partly used analog circuit to produce micro-curtage, and repeatedly cascade is amplified, to meet the required condition of different stimulated, also realize the function that charge accumulation is eliminated simultaneously.This stimulator adopts external wireless energy supply method, for patient, design specially, mainly for generation of artificial hearing, vision, it not the zoopery application for nerve electric stimulation therapy, adopt the method for titanium or titanium alloy encapsulation stimulator to improve installation cost, can not finely meet zoopery and adjust the requirement of a plurality of body internal stimulus device stimulus parameters, therefore not be suitable for the grouping experiment of animal.
Summary of the invention
The object of the present invention is to provide a kind ofly for zooperal full-implantation type nerve electric stimulation device, can implement spinal cord Epidural Electrical stimulates.The present invention also provides the external control system of this stimulator, and personal digital assistant (PDA, or title palm PC) can be controlled many stimulators by external controller and work simultaneously.
The invention discloses a kind of specially for zooperal full implantable neural electrical stimulation device, for easing pain and promoting the mechanism research of motion function rehabilitation after spinal cord injury, also can be used for the animal experiment study of other nervous system disease such as electronic stimulation parkinson, epilepsy.
For achieving the above object, the invention provides a kind of implantable neural electrical stimulation device, described device comprises personal digital assistant, external controller, body internal stimulus device and stimulating electrode, wherein:
Described personal digital assistant, work state information for recording laboratory animal information, body internal stimulus device and stimulating electrode, and provide the man machine interface that stimulus parameter is set, by double-direction radio radio communication, be connected with external controller, described stimulus parameter is transferred to described external controller, receives the work state information of body internal stimulus device that external controller sends and stimulating electrode simultaneously and show;
Described external controller, for and body internal stimulus device between utilize the inductive coupled of body interior loop and external coil, carry out the percutaneous wireless transmission of stimulus parameter and energy, receive the work state information of body internal stimulus device and stimulating electrode and send personal digital assistant to by twireless radio-frequency communication;
Described body internal stimulus device, for producing boost pulse according to described stimulus parameter, export stimulating electrode to, implement spinal nerves electricity irritation, by measurement electrode and by the contact impedance between stimulation target tissue, obtain stimulator and stimulating electrode work state information in animal body simultaneously.
In one embodiment of the invention, described external controller comprises radio-frequency signal generator, E class power amplifier module, energy and data transmission module, RF transceiver, microprocessor, Data Modulation module and battery module, wherein:
Described radio-frequency signal generator is connected with E class power amplifier module, radio-frequency signal generator produces radio-frequency carrier and carries out power amplification through E class power amplifier module, the output of E class power amplifier module is connected to energy and data transmission module, driving-energy and the work of data transmission module;
Described microprocessor is connected with RF transceiver, receive the stimulus parameter that personal digital assistant sends by twireless radio-frequency communication, send body internal stimulus device by the wireless stimulator transmitting of load-modulate module percutaneous and stimulating electrode work state information to personal digital assistant;
Described microprocessor is also connected with Data Modulation module, exports serially stimulus parameter to Data Modulation module, and the radio-frequency carrier that E class power amplifier module is exported to energy and data transmission module by Data Modulation module carries out Data Modulation;
The radiofrequency signal carrier wave of described modulation is sent to body internal stimulus device by the magnetic coupling of inside and outside coil, completes the percutaneous wireless transmission of energy and data;
Described battery module, for powering to described radio-frequency signal generator and described E class power amplifier module.
In one embodiment of the invention, described body internal stimulus device comprises energy and data reception module, rectification filtering module, DC/DC conversion module, data demodulation module, microprocessor, stimulus waveform generation module, impedance detection module and load-modulate module, wherein:
Described energy and data reception module, receive energy and the data that transmit from external controller for the magnetic coupling by body and between external coil;
Described energy and data reception module, also for being connected with rectification filtering module, and send energy to DC/DC conversion module by rectification filtering module, thereby to microprocessor and the power supply of stimulus waveform generation module thereafter;
Described energy and information receiving module, be also connected with data demodulation module, and data demodulation module is carried out demodulation by the Data Modulation ripple of energy and information receiving module reception, and exports demodulation data out to microprocessor;
Described microprocessor is connected with stimulus waveform generation module, according to the stimulus parameter of described demodulation, controls stimulus waveform generation module output boost pulse to stimulating electrode;
Described impedance detection module stimulates loop current acquiring size stimulating electrode and is stimulated the contact impedance between tissue by measuring under constant DC voltage excitation, determines the duty of stimulator and stimulating electrode;
Described load-modulate module is connected with impedance detection module, for being loaded to body interior loop according to what send that low and high level corresponding to data access different impedances, by load-modulate effect, by the work state information of body internal stimulus device and stimulating electrode, the coupling by inside and outside coil is sent to external controller.
In one embodiment of the invention, described stimulating electrode is the multiconductor electrode based on flexible PCB technique, in Operation animal body, by electrode both sides aperture, adopt neural spine or muscular fascia fixed form to reduce displacement incidence rate and the crash rate after electrode is implanted.
In one embodiment of the invention, in described stimulating electrode, adopt polyimides to carry out insulation-encapsulated to a plurality of gold-plated electrodes contact, both sides aperture, for fixing in the operation of neural spine or the enterprising column electrode of muscular fascia, reduces displacement incidence rate and crash rate after electrode surgery is implanted.
The present invention also provides a kind of implantable neural electrical stimulator, and described system comprises personal digital assistants, a plurality of external controller, a plurality of body internal stimulus device and a plurality of stimulating electrode, wherein:
Described personal digital assistant, work state information for recording laboratory animal information, body internal stimulus device and stimulating electrode, and provide the man machine interface that stimulus parameter is set, by double-direction radio radio communication, be connected to external controller, and described stimulus parameter is transferred to described external controller, receive the work state information of body internal stimulus device that external controller transmits and stimulating electrode simultaneously and show;
Described external controller, for and body internal stimulus device between utilize the inductive coupled of body interior loop and external coil, carry out the percutaneous wireless transmission of stimulus parameter and energy, receive the work state information of body internal stimulus device and stimulating electrode and send personal digital assistant to by twireless radio-frequency communication;
Described body internal stimulus device, for producing according to described stimulus parameter the stimulating electrode that boost pulse exports Operation epidural space to, implements spinal nerves electricity irritation;
Described body internal stimulus device, obtains the work state information of stimulator and stimulator electrode by impedance measurement, utilize body interior loop to the load-modulate of external coil by the wireless external controller that is sent to of status information percutaneous;
Described personal digital assistant and a plurality of external controller form the network of star topology, and personal digital assistant is as the Centroid of this star network;
By the battery powered external controller that comprises transmitting coil, be placed in animal and wear in vest pocket, external transmitting coil with implant in the body of the subcutaneous stimulator of back part of animal receiving coil collimation over against;
User is by programme stimulus parameter be sent to a plurality of external controllers of personal digital assistant, by stimulus parameter, the coupling percutaneous by body interior loop and external coil is wireless is sent to corresponding body internal stimulus device for external controller, and the boost pulse that control volume internal stimulus device produces special parameter is connected to corresponding stimulating electrode; The work state information of stimulator and stimulating electrode is obtained in the measurement of body internal stimulus device, by body interior loop, the load-modulate of external coil is sent to external controller by status information.
In general, the above technical scheme of conceiving by the present invention compared with prior art, has following beneficial effect:
1, adopt wireless data transmission technology, personal digital assistant, body internal stimulus device and external controller all communicate by wireless signal, and can form wireless network and manage, can build the control system that many group stimulators are worked simultaneously, can be a plurality of external controller programming stimulus parameters by PDA transmitting control commands word, and by external controller, control corresponding body internal stimulus device and work, provide the real-time customization of grouping zoopery scheme to implement;
2, adopt wireless energy transfer mode to carry out percutaneous energy supply to body internal stimulus device, transmission when having realized data and energy, the infection risk of having avoided external battery powered percutaneous wire and having caused and disposable battery exhaust the operation causing and change risk, for long-term zoopery provides advanced means;
3, the flexible adjustable boost pulse of body internal stimulus circuit output parameter, and produce the biphasic pulse waveform of charge balance, eliminate the electrochemical reaction that charge accumulated causes; Utilize impedance detection and load-modulate that the wireless percutaneous of the work state information of stimulator and stimulating electrode is sent to external controller, through twireless radio-frequency communication, be sent to PDA, for experimenter understands experimental state in time, provide convenient hands section; Adopt the silica gel material encapsulation of bio-compatible, reduce installation cost, be particularly suitable for animal experiment study;
4, stimulating electrode is the multiconductor electrode based on flexible PCB technique, in Operation animal body, by electrode both sides aperture, adopt neural spine or muscular fascia fixed form to reduce displacement incidence rate and the crash rate after electrode is implanted, the cost of electrode is low, is particularly suitable for animal experiment study;
5, nerve electric stimulation device of the present invention can be applicable to the minitype animal experiments such as rat corresponding segments of spinal cord is implemented to epidural spinal cord stimulation trial, the analgesic mechanism of research ESCS, ESCS be the mechanism of action to maincenter mode generator in spinal cord to the effect of spinal cord injury position neuranagenesis and ESCS, curative effect and the mechanism of motion function rehabilitation after illustrating ESCS analgesia and promoting spinal cord injury, instruct the clinical practice of ESCS, so the present invention have higher scientific meaning and important economic worth.
Accompanying drawing explanation
Fig. 1 is the structural representation of implantable neural electrical stimulation device of the present invention;
Fig. 2 is the control command word that in one embodiment of the invention, PDA and a plurality of external controller Radio-Frequency Wireless Communication are used;
Fig. 3 is that the stimulus waveform in one embodiment of the invention produces schematic diagram;
Fig. 4 is the epidural stimulating electrode structure chart in one embodiment of the invention;
Fig. 5 is for the zooperal schematic diagram that divides into groups in one embodiment of the invention;
Fig. 6 is for the animal experiment study schematic diagram of spinal cord stimulation trial and weight-losing combination treatment in one embodiment of the invention.
The specific embodiment
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.In addition,, in each embodiment of described the present invention, involved technical characterictic just can not combine mutually as long as do not form each other conflict.
System of the present invention forms as shown in Figure 1, comprises personal digital assistant (PDA), external controller, body internal stimulus device and stimulating electrode.User is by the PDA stimulus parameter of programming, the work state information of recording laboratory animal information and body internal stimulus device, PDA is connected with external controller by double-direction radio radio communication, external controller utilizes the perception between body interior loop 1 and external coil 2 to connect stimulus parameter and the energy wireless transmission donor internal stimulus device of PDA programming, body internal stimulus device produces according to stimulus parameter the boost pulse needing and exports stimulating electrode enforcement nerve electric stimulation to, body internal stimulus device is by monitoring electrode state simultaneously, utilize the perception connection between the coil of inside and outside that information is fed back to external controller, external controller sends PDA to by wireless radio frequency mode.
External controller is sent to the mode of operation of the boost pulse parameter of programming and selection the body internal stimulus device of laboratory animal by sending the command control word (Fig. 2) of specific format, wherein check code is used for identifying control command word, model selection comprises stimulus modelity and impedance detection pattern: if stimulus modelity, body internal stimulus device is according to the corresponding boost pulse parameter generating of the control command word two-way stimulation pulse signal u receiving
1and u
2(Fig. 3), and be welded to gold-plated via hole 9 and be connected to respectively electrode contacts 6 and electrode contacts 7 (Fig. 4) by thering is the multiply stainless steel silk of TEFLON coating, synthetic negative 3 is at charge balance overlap biphasic impulse waveform ustim stimulating neural tissue front, that positive 5 has certain hour section 4 intervals between rear, positive negative, eliminate the electrochemical reaction that charge accumulated causes simultaneously, avoid damaging biological nervous tissue, the interval between positive and negative phase waveform makes positive balanced waveform can not block the action potential propagation that negative stimulus waveform causes; If impedance detection pattern, external controller will receive the work state information of body internal stimulus device and stimulating electrode and be sent to PDA.
Stimulating electrode adopts flexible PCB fabrication techniques, as shown in Figure 4, utilize polyimides to carry out insulation-encapsulated to gold-plated electrode contact 6 and 7, by stimulating electrode Operation destination organization, by the both sides aperture 8 employing neural spine of electrode mid portion or displacement incidence rate and the crash rate after muscular fascia fixed form reduction implantation.
The present invention can be used for animal grouping experiment, and as shown in Figure 5, personal digital assistant (PDA) 10 and a plurality of external controllers 11 form the network of star topologies, and personal digital assistant 10 is as the Centroid of this star network simultaneously.The battery powered external controller that comprises transmitting coil 18 is placed in to animal to be worn in vest pocket 13, transmitting coil 1 with implant receiving coil 2 collimations that the subcutaneous body internal stimulus of back part of animal device 12 comprises over against, user is by personal digital assistant 10 programming stimulus parameters and be sent to a plurality of external controllers 11, external controller 11 is by stimulus parameter by the wireless body internal stimulus device 12 that is sent to of coupling percutaneous of body interior loop 1 and external coil 2, and the boost pulse that control volume internal stimulus device produces special parameter is connected to stimulating electrode 14.
The present invention can be used for the animal experiment study of weight-losing and spinal cord stimulation trial combination treatment, as shown in Figure 6, aluminium flake 16 is connected with the loss of weight lever 17 of treadmill 18, the battery powered external controller that comprises transmitting coil 1 11 is fixed on to the outer surface of aluminium flake, the velcro 15 of the back of vest that animal is worn 19 by aluminium flake 16 inner surfaces cements with aluminium flake 16, simultaneously the transmitting coil 1 of external controller 11 and receiving coil 2 collimations of implanting the subcutaneous body internal stimulus of back part of animal device 12 over against.User is by personal digital assistant 10 programming stimulus parameters and be sent to external controller 11, external controller 11 by stimulus parameter by the wireless body internal stimulus device 12 that is sent to of coupling percutaneous of body interior loop 1 and external coil 2, the boost pulse that control volume internal stimulus device 12 produces special parameter is sent to the stimulating electrode 14 of implanting spinal cord epidural space, implements spinal cord stimulation trial.
Those skilled in the art will readily understand; the foregoing is only preferred embodiment of the present invention; not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (6)
1. an implantable neural electrical stimulation device, is characterized in that, described device comprises personal digital assistant, external controller, body internal stimulus device and stimulating electrode, wherein:
Described personal digital assistant, work state information for recording laboratory animal information, body internal stimulus device and stimulating electrode, and provide the man machine interface that stimulus parameter is set, by double-direction radio radio communication, be connected with external controller, described stimulus parameter is transferred to described external controller, receives the work state information of body internal stimulus device that external controller sends and stimulating electrode simultaneously and show;
Described external controller, for and body internal stimulus device between utilize the inductive coupled of body interior loop and external coil, carry out the percutaneous wireless transmission of stimulus parameter and energy, receive the work state information of body internal stimulus device and stimulating electrode and send personal digital assistant to by twireless radio-frequency communication;
Described body internal stimulus device, for producing boost pulse according to described stimulus parameter, export stimulating electrode to, implement spinal nerves electricity irritation, by measurement electrode and by the contact impedance between stimulation target tissue, obtain stimulator and stimulating electrode work state information in animal body simultaneously.
2. implantable neural electrical stimulation device as claimed in claim 1, it is characterized in that, described external controller comprises radio-frequency signal generator, E class power amplifier module, energy and data transmission module, RF transceiver, microprocessor, Data Modulation module and battery module, wherein:
Described radio-frequency signal generator is connected with E class power amplifier module, radio-frequency signal generator produces radio-frequency carrier and carries out power amplification through E class power amplifier module, the output of E class power amplifier module is connected to energy and data transmission module, driving-energy and the work of data transmission module;
Described microprocessor is connected with RF transceiver, receive the stimulus parameter that personal digital assistant sends by twireless radio-frequency communication, send body internal stimulus device by the wireless stimulator transmitting of load-modulate module percutaneous and stimulating electrode work state information to personal digital assistant;
Described microprocessor is also connected with Data Modulation module, exports serially stimulus parameter to Data Modulation module, and the radio-frequency carrier that E class power amplifier module is exported to energy and data transmission module by Data Modulation module carries out Data Modulation;
The radiofrequency signal carrier wave of described modulation is sent to body internal stimulus device by the magnetic coupling of inside and outside coil, completes the percutaneous wireless transmission of energy and data;
Described battery module, for powering to described radio-frequency signal generator and described E class power amplifier module.
3. implantable neural electrical stimulation device as claimed in claim 1 or 2, it is characterized in that, described body internal stimulus device comprises energy and data reception module, rectification filtering module, DC/DC conversion module, data demodulation module, microprocessor, stimulus waveform generation module, impedance detection module and load-modulate module, wherein:
Described energy and data reception module, receive energy and the data that transmit from external controller for the magnetic coupling by body and between external coil;
Described energy and data reception module, also for being connected with rectification filtering module, and send energy to DC/DC conversion module by rectification filtering module, thereby to microprocessor and the power supply of stimulus waveform generation module thereafter;
Described energy and information receiving module, be also connected with data demodulation module, and data demodulation module is carried out demodulation by the Data Modulation ripple of energy and information receiving module reception, and exports demodulation data out to microprocessor;
Described microprocessor is connected with stimulus waveform generation module, according to the stimulus parameter of described demodulation, controls stimulus waveform generation module output boost pulse to stimulating electrode;
Described impedance detection module stimulates loop current acquiring size stimulating electrode and is stimulated the contact impedance between tissue by measuring under constant DC voltage excitation, determines the duty of stimulator and stimulating electrode;
Described load-modulate module is connected with impedance detection module, for being loaded to body interior loop according to what send that low and high level corresponding to data access different impedances, by load-modulate effect, the work state information of body internal stimulus device and stimulating electrode is sent to external controller by inside and outside coil coupling.
4. implantable neural electrical stimulation device as claimed in claim 1 or 2, it is characterized in that, described stimulating electrode is the multiconductor electrode based on flexible PCB technique, in Operation animal body, by electrode both sides aperture, adopt neural spine or muscular fascia fixed form to reduce displacement incidence rate and the crash rate after electrode is implanted.
5. implantable neural electrical stimulation device as claimed in claim 4, it is characterized in that, in described stimulating electrode, adopt polyimides to carry out insulation-encapsulated to a plurality of gold-plated electrodes contact, both sides aperture, for fixing in the operation of neural spine or the enterprising column electrode of muscular fascia, reduces displacement incidence rate and crash rate after electrode surgery is implanted.
6. an implantable neural electrical stimulator, is characterized in that, described system comprises personal digital assistants, a plurality of external controller, a plurality of body internal stimulus device and a plurality of stimulating electrode, wherein:
Described personal digital assistant, work state information for recording laboratory animal information, body internal stimulus device and stimulating electrode, and provide the man machine interface that stimulus parameter is set, by double-direction radio radio communication, be connected to external controller, and described stimulus parameter is transferred to described external controller, receive the work state information of body internal stimulus device that external controller transmits and stimulating electrode simultaneously and show;
Described external controller, for and body internal stimulus device between utilize the inductive coupled of body interior loop and external coil, carry out the percutaneous wireless transmission of stimulus parameter and energy, receive the work state information of body internal stimulus device and stimulating electrode and send personal digital assistant to by twireless radio-frequency communication;
Described body internal stimulus device, for producing according to described stimulus parameter the stimulating electrode that boost pulse exports Operation epidural space to, implements spinal nerves electricity irritation;
Described body internal stimulus device, obtains the work state information of stimulator and stimulator electrode by impedance measurement, utilize body interior loop to the load-modulate of external coil by the wireless external controller that is sent to of status information percutaneous;
Described personal digital assistant and a plurality of external controller form the network of star topology, and personal digital assistant is as the Centroid of this star network;
By the battery powered external controller that comprises transmitting coil, be placed in animal and wear in vest pocket, external transmitting coil with implant in the body of the subcutaneous stimulator of back part of animal receiving coil collimation over against;
User is by programme stimulus parameter be sent to a plurality of external controllers of personal digital assistant, by stimulus parameter, the coupling percutaneous by body interior loop and external coil is wireless is sent to corresponding body internal stimulus device for external controller, and the boost pulse that control volume internal stimulus device produces special parameter is connected to corresponding stimulating electrode; The work state information of stimulator and stimulating electrode is obtained in the measurement of body internal stimulus device, by body interior loop, the load-modulate of external coil is sent to external controller by status information.
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