CN104000589A - Positioning method and positioning device of magnetic resonance imaging system - Google Patents

Positioning method and positioning device of magnetic resonance imaging system Download PDF

Info

Publication number
CN104000589A
CN104000589A CN201310061082.6A CN201310061082A CN104000589A CN 104000589 A CN104000589 A CN 104000589A CN 201310061082 A CN201310061082 A CN 201310061082A CN 104000589 A CN104000589 A CN 104000589A
Authority
CN
China
Prior art keywords
wish
imaging system
resonance imaging
magnetic resonance
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201310061082.6A
Other languages
Chinese (zh)
Other versions
CN104000589B (en
Inventor
黄艳图
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Shenzhen Magnetic Resonance Ltd
Original Assignee
Siemens Shenzhen Magnetic Resonance Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Shenzhen Magnetic Resonance Ltd filed Critical Siemens Shenzhen Magnetic Resonance Ltd
Priority to CN201310061082.6A priority Critical patent/CN104000589B/en
Publication of CN104000589A publication Critical patent/CN104000589A/en
Application granted granted Critical
Publication of CN104000589B publication Critical patent/CN104000589B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

The invention discloses a positioning method and a positioning device of a magnetic resonance imaging system. The positioning method of the magnetic resonance imaging system comprises the steps of acquiring an image of a tested object; displaying the image; identifying a to-be-tested part in the displayed image; and conveying the identified to-be-tested part to the center of a magnetic field by controlling the movement of a sickbed of the magnetic resonance imaging system. According to the positioning method and the positioning device provided by the invention, the security of the tested object (a patient) caused by the magnetic resonance imaging system can be improved by avoiding the use of a laser transmitter, and the simple operation can be realized without the need for manual control of an operator (a doctor), therefore the efficiency and accuracy can be improved.

Description

A kind of localization method of magnetic resonance imaging system and positioner
Technical field
The present invention relates to magnetic resonance imaging system technical field, be specifically related to a kind of localization method and positioner of magnetic resonance imaging system.
Background technology
Nuclear magnetic resonance (Magnetic Resonance Imaging, MRI) is to utilize magnetic resonance phenomenon to carry out a kind of technology of imaging.The principle of magnetic resonance phenomenon mainly comprises: the atomic nucleus that comprises odd number proton, the hydrogen nuclei for example extensively existing in human body, its proton has spin motion, just as a small magnet, and the spin axis of these small magnets does not have certain rule, if apply exterior magnetic field, these small magnets rearrange the magnetic line of force by exterior magnetic field, be specially at the both direction that is either parallel or anti-parallel to the exterior magnetic field magnetic line of force and arrange, the above-mentioned direction that is parallel to the exterior magnetic field magnetic line of force is called to positive longitudinal axis, the above-mentioned direction that is antiparallel to the exterior magnetic field magnetic line of force is called to negative longitudinal axis, atomic nucleus only has longitudinal magnetization component, and this longitudinal magnetization component not only has direction but also have amplitude.With the atomic nucleus of radio frequency (Radio Frequency, RF) pulse excitation in exterior magnetic field of characteristic frequency, make these nuclear spin axiss depart from positive longitudinal axis or negative longitudinal axis, produce resonance, magnetic resonance phenomenon that Here it is.After the above-mentioned nuclear spin axis being excited departs from positive longitudinal axis or negative longitudinal axis, this atomic nucleus has just had component of transverse magnetisation.Stop launching after radio-frequency pulse, the atomic nucleus transmitting echo-signal being excited, the energy of absorption is progressively discharged with electromagnetic form, and the state before its phase place and energy level all return to and excite, can rebuild image by the same ripple signal of atomic nucleus transmitting through further processing such as space encodings.
In magnetic resonance imaging system, thereby the wish of detected object detection position should be placed on magnetic field center and reach best imaging effect, therefore before carrying out nuclear magnetic resonance, need to calculate wish and detect the distance between position and magnetic field center, thereby then move this distance and wish is detected to position be placed on magnetic field center by controlling the sick bed of magnetic resonance imaging system.That is to say, the distance that how to confirm wish detects between position and magnetic field center is those skilled in the art's technical issues that need to address.
In the prior art, use generating laser to solve the problems of the technologies described above.The localization method that the positioner that generating laser forms carries out comprises three steps: first, sick bed is moved to wish and detect the roughly position in generating laser below, position; Secondly, open generating laser, and sick bed is moved to the position of wish detection position under generating laser; Finally, close generating laser, sick bed is moved to a fixed range, i.e. horizontal range between generating laser and magnetic field center, makes wish detect position in magnetic field center.
But the defect of technique scheme is, one, in the process of location, laser likely hurts patient or doctor's eyes; Two, the process of location comprises the step such as coarse adjustment and fine tuning, and needs doctor's manual operation sick bed in operation room, and therefore comparatively loaded down with trivial details the and accuracy of the process of location is also difficult to ensure.
Summary of the invention
For above-mentioned technical problem, the object of the embodiment of the present invention is to provide a kind of localization method of magnetic resonance imaging system, comprises, gathers the image of detected object; Show described image; In shown image, identify wish and detect position; By controlling the movement of sick bed of described magnetic resonance imaging system, identified wish is detected to position and be transported to described magnetic field center.
In one embodiment of the invention, the position that described wish is detected is transported to described magnetic field center, comprise, the position of the position according to the ratio of described image, described wish detection position in described image and the magnetic field center of described magnetic resonance imaging system, the wish that estimation identifies detects the distance of position and described magnetic field center.
In one embodiment of the invention, the position that described wish is detected is transported to described magnetic field center, comprise, follow the trail of the wish that identifies and detect the position of position in described image and arrive at described magnetic field center through a precalculated position and moving a fixed range from described precalculated position.
In one embodiment of the invention, described wish detects geometric center or the specified location in user that the position of position in described image is described wish detection position.
The object of the embodiment of the present invention is also a kind of positioner of magnetic resonance imaging system, comprise an image acquisition part, a display section, an identification division and a control section, wherein, described image acquisition part, for gather the image of detected object and by described image transmitting to described display section; Described display section, for showing described image; Described identification division, detects position for identify wish at shown image; Described control section, for the movement of the sick bed by controlling described magnetic resonance imaging system, detects position by identified wish and is transported to described magnetic field center.
In one embodiment of the invention, described control section also comprises an evaluation unit, described evaluation unit, for according to detecting position in the position of described image and the position of the magnetic field center of described magnetic resonance imaging system according to the ratio of described image, the wish that identifies, the wish that estimation identifies detects the distance of position and described magnetic field center.
In one embodiment of the invention, described control section also comprises a tracing unit, described tracing unit, detects position and arrives at described magnetic field center in the position of described image through a precalculated position and moving a fixed range from described precalculated position for following the trail of identified wish.
In one embodiment of the invention, under the described image acquisition part in described precalculated position.
In one embodiment of the invention, described wish detects geometric center or the specified location in user that the position of position in described image is described wish detection position.
The embodiment of the present invention also provides a kind of magnetic resonance imaging system, comprises above-mentioned arbitrary positioner.
Can find out, localization method according to a particular embodiment of the invention and positioner.
Brief description of the drawings
Fig. 1 is according to the schematic diagram of the localization method of the first specific embodiment of the present invention.
Fig. 2 is according to the schematic diagram of the localization method of the second specific embodiment of the present invention.
Fig. 3 is the schematic diagram of positioner according to an embodiment of the invention.
Fig. 4 is according to the schematic diagram of the shown image in display section of the positioner of the first specific embodiment of the present invention and the second specific embodiment.
Detailed description of the invention
In order to make object, technical scheme and the advantage of the embodiment of the present invention clearer, below for example the embodiment of the present invention is described in further detail.
In order to solve the problem proposing in background technology, the present invention proposes.
Particularly, the present invention:
1. utilize video camera and display (or touch screen) to substitute generating laser, wherein video camera is arranged on sick bed top and display (or touch screen) is arranged on the main frame on the guidance panel of magnetic resonance imaging system or between controlling;
2. camera acquisition detected object (patient) image on one's sick bed, operator (doctor) detect position in the upper wish of selecting of display (or touch screen), and then control assembly is by following the tracks of or the mode such as estimation moves to magnetic field center by wish test section position automatically.
Localization method according to a particular embodiment of the invention and positioner, thereby avoid using generating laser to improve the safety of magnetic resonance imaging system for detected object (patient), and simple to operate without operator (doctor) thus manually control and improved efficiency and accuracy.
The first specific embodiment
Comprise according to the localization method of the first specific embodiment of the present invention: the image that gathers detected object; Show described image; In shown image, identify wish and detect position; By controlling the movement of sick bed of described magnetic resonance imaging system, identified wish is detected to position and be transported to described magnetic field center.Fig. 1 is according to the schematic diagram of the localization method of the first specific embodiment of the present invention, Fig. 3 is the schematic diagram of positioner according to an embodiment of the invention, and Fig. 4 is according to the schematic diagram of the shown image in display section of the positioner of the first specific embodiment of the present invention and the second specific embodiment.
As shown in figures 1 and 3, comprise video camera 101 and display 102 according to the positioner 100 of the first specific embodiment of the present invention, video camera 101 for gather the image of detected object (patient) and by described image transmitting to display 102, show that 102 for showing described image, wherein, video camera 101 is installed on sick bed top, display 102 can be arranged on the guidance panel place (as shown in Figure 3) of magnetic resonance imaging system, also can be arranged on the main frame of magnetic resonance imaging system.
Positioner 100 also comprises identification division and control section (not shown), and identification division detects position 201 for identify wish at shown image; Control section, for the movement of the sick bed by controlling described magnetic resonance imaging system, detects position by identified wish and is transported to described magnetic field center 202.
In the first specific embodiment of the present invention, video camera 101 gathers the image of detected object 200, and by this image transmitting to display 102, display 102 shows the image of the detected object 200 that video camera 101 gathers, as shown in Figure 4, the image of the detected object 200 that image pick-up device 101 gathers is presented on display 102, and this image comprises the magnet of detected object whole body, sick bed and magnetic resonance imaging system, on this image, utilize identification division can define wish and detect position 201, as shown in Figure 4, wherein identification division can be that mouse, felt pen etc. are for defining the peripheral hardware of image range, on the picture of identification division definition, identification division can define a region also can define a central point, and wish detects 201 center, position and indicates a cross figure (as shown in Figure 4), after success defines wish detection position 201, by controlling the movement of sick bed of described magnetic resonance imaging system, control section detects position 201 by wish and is transported to magnetic field center 202, wherein, control section detects the position of the magnetic field center 202 of the position of position 201 in described image and described magnetic resonance imaging system according to described wish, the wish that estimation identifies detects the distance L 1 of position 201 and described magnetic field center 202, wish surveyed area in identification division definition is a region, control section detects the position at position 201 using the geometric center in this region as wish.It is geometric center or the specified location in user that described wish detects position that described wish detects the position of position in described image.
Particularly, control section also comprises evaluation unit, this evaluation unit can detect the formula that the parameter such as coordinate position and the coordinate position of magnetic field center 202 of position 201 in image forms according to the ratio of described image, wish, wish is detected to position 201 and estimate with the distance of magnetic field center 202.For example, the coordinate position at known magnetic field center and some and the relatively-stationary coordinate position of magnetic field center, according to the ratio of described image, on described image, proportionally estimate wish and detect the coordinate position at position, and then show that wish detects the distance of position and magnetic field center.
The second specific embodiment
Comprise according to the localization method of the second specific embodiment of the present invention: the image that gathers detected object; Show described image; In shown image, identify wish and detect position; By controlling the movement of sick bed of described magnetic resonance imaging system, identified wish is detected to position and be transported to described magnetic field center.Fig. 2 is according to the schematic diagram of the localization method of the second specific embodiment of the present invention, Fig. 3 is the schematic diagram of positioner according to an embodiment of the invention, and Fig. 4 is according to the schematic diagram of the shown image in display section of the positioner of the first specific embodiment of the present invention and the second specific embodiment.
As shown in Figures 2 and 3, comprise video camera 101 and display 102 according to the positioner 100 of the second specific embodiment of the present invention, video camera 101 for gather the image of detected object (patient) and by described image transmitting to display 102, show that 102 for showing described image, wherein, video camera 101 is installed on sick bed top, display 102 can be arranged on the guidance panel place (as shown in Figure 3) of magnetic resonance imaging system, also can be arranged on the main frame of magnetic resonance imaging system.
Positioner 100 also comprises identification division and control section (not shown), and identification division detects position for identify wish at shown image; Control section, for the movement of the sick bed by controlling described magnetic resonance imaging system, detects position by identified wish and is transported to described magnetic field center.
In the first specific embodiment of the present invention, video camera 101 gathers the image of detected object 200, and by this image transmitting to display 102, display 102 shows the image of the detected object 200 that video camera 101 gathers, as shown in Figure 4, the image of the detected object 200 that image pick-up device 101 gathers is presented on display 102, and this image comprises the magnet of detected object whole body, sick bed and magnetic resonance imaging system, on this image, utilize identification division can define wish detect position 201, as shown in Figure 4, wherein identification division can be mouse, felt pen etc. for defining the peripheral hardware of image range, wish detect 201 center, position indicate a cross figure, after success defines wish detection position 201, by controlling the movement of sick bed of described magnetic resonance imaging system, control section detects position 201 by wish and is transported to magnetic field center, wherein, the wish that identifies of following the trail of control section detects position and arrives at described magnetic field center through a precalculated position and moving a fixed range L2 from described precalculated position, particularly, control section comprises tracing unit, in the process moving with sick bed at detected object, described tracing unit is constantly followed the trail of the relation in the precalculated position in wish detection position and the image identifying, the position relationship of the magnetic field center of this precalculated position and magnetic resonance imaging system i.e. distance is determined and is known, in other words, detect in wish after Yu Gai precalculated position, the center coincidence at position, wish detects that the distance that moves to magnetic field center of position is also just determined and cicada.It is geometric center or the specified location in user that described wish detects position that described wish detects the position of position in described image.
Success defines wish and detects behind position, positioner detects position using the wish of current video frame and preserves as target, then in video next frame, search the part of mating most with described target (i.e. wish detection position) as new target and preserve, and repeating this process.In other words, following the trail of wish test section is exactly the process of constantly mating target in video next frame, exists multiple image processing method can realize this image object tracing process in prior art.This precalculated position can be under video camera or other positions, under preferred video camera, thereby reduces error as far as possible; Meanwhile, can be on the image of display, locate to indicate this precalculated position on the sick bed of magnetic resonance imaging system etc., so that target can be followed the trail of while arriving at this precalculated position effectively.
Localization method of the present invention and positioner based on above-mentioned two specific embodiments have plurality of advantages, comprising: thus avoid using generating laser to improve the safety of magnetic resonance imaging system for detected object (patient), and simple to operate without operator (doctor) thus manually control and improved efficiency and accuracy.
The above, be only preferred embodiment of the present invention, is not intended to limit protection scope of the present invention.Can be to being improved appropriately according to a preferred embodiment of the invention, to adapt to the concrete needs of concrete condition in concrete implementation process.Therefore be appreciated that the specific embodiment of the present invention as herein described just plays an exemplary role, not in order to limit the scope of the invention.

Claims (10)

1. a localization method for magnetic resonance imaging system, comprises,
Gather the image of detected object;
Show described image;
In shown image, identify wish and detect position;
By controlling the movement of sick bed of described magnetic resonance imaging system, identified wish is detected to position and be transported to described magnetic field center.
2. the localization method of magnetic resonance imaging system according to claim 1, wherein, the position that described wish is detected is transported to described magnetic field center, comprise, the position of the position according to the ratio of described image, described wish detection position in described image and the magnetic field center of described magnetic resonance imaging system, the wish that estimation identifies detects the distance of position and described magnetic field center.
3. the localization method of magnetic resonance imaging system according to claim 1, wherein, the position that described wish is detected is transported to described magnetic field center, comprise, follow the trail of the wish that identifies and detect the position of position in described image and arrive at described magnetic field center through a precalculated position and moving a fixed range from described precalculated position.
4. according to the localization method of the magnetic resonance imaging system described in claim 2 or 3, wherein, it is geometric center or the specified location in user that described wish detects position that described wish detects the position of position in described image.
5. a positioner for magnetic resonance imaging system, comprises an image acquisition part, a display section, an identification division and a control section, wherein,
Described image acquisition part, for gather the image of detected object and by described image transmitting to described display section;
Described display section, for showing described image;
Described identification division, detects position for identify wish at shown image;
Described control section, for the movement of the sick bed by controlling described magnetic resonance imaging system, detects position by identified wish and is transported to described magnetic field center.
6. the positioner of magnetic resonance imaging system according to claim 5, wherein, described control section also comprises an evaluation unit, described evaluation unit, for according to detecting position in the position of described image and the position of the magnetic field center of described magnetic resonance imaging system according to the ratio of described image, the wish that identifies, the wish that estimation identifies detects the distance of position and described magnetic field center.
7. the positioner of magnetic resonance imaging system according to claim 5, wherein, described control section also comprises a tracing unit, described tracing unit, detects position and arrives at described magnetic field center in the position of described image through a precalculated position and moving a fixed range from described precalculated position for following the trail of identified wish.
8. the positioner of magnetic resonance imaging system according to claim 7, wherein, under the described image acquisition part in described precalculated position.
9. according to the positioner of arbitrary described magnetic resonance imaging system in claim 6-8, wherein, it is geometric center or the specified location in user that described wish detects position that described wish detects the position of position in described image.
10. a magnetic resonance imaging system, wherein, comprises as the positioner as described in arbitrary in claim 5-9.
CN201310061082.6A 2013-02-27 2013-02-27 The localization method of a kind of magnetic resonance imaging system and positioner Active CN104000589B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310061082.6A CN104000589B (en) 2013-02-27 2013-02-27 The localization method of a kind of magnetic resonance imaging system and positioner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310061082.6A CN104000589B (en) 2013-02-27 2013-02-27 The localization method of a kind of magnetic resonance imaging system and positioner

Publications (2)

Publication Number Publication Date
CN104000589A true CN104000589A (en) 2014-08-27
CN104000589B CN104000589B (en) 2016-12-28

Family

ID=51361697

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310061082.6A Active CN104000589B (en) 2013-02-27 2013-02-27 The localization method of a kind of magnetic resonance imaging system and positioner

Country Status (1)

Country Link
CN (1) CN104000589B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105476634A (en) * 2014-09-15 2016-04-13 西门子(深圳)磁共振有限公司 Imaging device and positioning device
CN105726025A (en) * 2014-12-09 2016-07-06 Ge医疗系统环球技术有限公司 Magnetic resonance imaging scanning method
CN107144805A (en) * 2017-06-09 2017-09-08 创领心律管理医疗器械(上海)有限公司 A kind of synthesis field method of testing of lower limb model and magnetic resonance imaging safety evaluation
CN107861079A (en) * 2017-11-03 2018-03-30 上海联影医疗科技有限公司 Method, magnetic resonance system and the computer-readable recording medium of local coil positioning
CN108968960A (en) * 2018-06-27 2018-12-11 上海联影医疗科技有限公司 Localization method and magnetic resonance system for magnetic resonance system
CN113908452A (en) * 2021-10-15 2022-01-11 国宏国康(北京)健康科技发展有限公司 Photon treatment auxiliary positioning illumination system and method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03258244A (en) * 1990-03-09 1991-11-18 Toshiba Corp Tomographic equipment
US5588430A (en) * 1995-02-14 1996-12-31 University Of Florida Research Foundation, Inc. Repeat fixation for frameless stereotactic procedure
CN1476813A (en) * 2002-07-18 2004-02-25 西门子公司 Patient-locating method and device for medical diagnostic or therapeutic equipment
CN201384493Y (en) * 2009-03-12 2010-01-20 西门子迈迪特(深圳)磁共振有限公司 Positioning device used for magnetic resonance system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03258244A (en) * 1990-03-09 1991-11-18 Toshiba Corp Tomographic equipment
US5588430A (en) * 1995-02-14 1996-12-31 University Of Florida Research Foundation, Inc. Repeat fixation for frameless stereotactic procedure
CN1476813A (en) * 2002-07-18 2004-02-25 西门子公司 Patient-locating method and device for medical diagnostic or therapeutic equipment
CN201384493Y (en) * 2009-03-12 2010-01-20 西门子迈迪特(深圳)磁共振有限公司 Positioning device used for magnetic resonance system

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105476634A (en) * 2014-09-15 2016-04-13 西门子(深圳)磁共振有限公司 Imaging device and positioning device
CN105726025A (en) * 2014-12-09 2016-07-06 Ge医疗系统环球技术有限公司 Magnetic resonance imaging scanning method
CN107144805A (en) * 2017-06-09 2017-09-08 创领心律管理医疗器械(上海)有限公司 A kind of synthesis field method of testing of lower limb model and magnetic resonance imaging safety evaluation
CN107861079A (en) * 2017-11-03 2018-03-30 上海联影医疗科技有限公司 Method, magnetic resonance system and the computer-readable recording medium of local coil positioning
CN107861079B (en) * 2017-11-03 2020-04-24 上海联影医疗科技有限公司 Method for local coil localization, magnetic resonance system and computer-readable storage medium
CN108968960A (en) * 2018-06-27 2018-12-11 上海联影医疗科技有限公司 Localization method and magnetic resonance system for magnetic resonance system
CN113908452A (en) * 2021-10-15 2022-01-11 国宏国康(北京)健康科技发展有限公司 Photon treatment auxiliary positioning illumination system and method

Also Published As

Publication number Publication date
CN104000589B (en) 2016-12-28

Similar Documents

Publication Publication Date Title
CN104000589A (en) Positioning method and positioning device of magnetic resonance imaging system
US20070219443A1 (en) Magnetic resonance marker based position and orientation probe
CA2960178A1 (en) Noise suppression methods and apparatus
JP6782562B2 (en) Magnetic Resonance Imaging Systems and Methods
WO2014033591A1 (en) Motion tracking based on fast image acquisition
US9759786B2 (en) Magnetic resonance apparatus and method for preparing a sensitivity map
US20100176800A1 (en) Coil position detection
CN105044636A (en) Method, system and magnetic resonance apparatus for compensating for inhomogeneities in the magnetic field
CN104101853A (en) Method and magnetic resonance system to determine a resonance frequency deviation
CN110857972B (en) System and method for waveform optimization for tilt scanning
JP2019141602A (en) Magnetic resonance imaging device and method for identifying position of rf coil
JP6537767B2 (en) Magnetic resonance imaging apparatus and power control method of magnetic resonance imaging apparatus
US9658306B2 (en) Magnetic resonance imaging method and apparatus
US20230366963A1 (en) Systems and methods for dynamically extending magnetic resonance imaging of a subject
CN105203977A (en) Magnetic resonance apparatus defining a sequence protocol for the magnetic resonance apparatus
CN104076309A (en) Method for the adjustment of at least one magnetic resonance image data set of a movable examination object and correspondingly designed magnetic resonance device
CN104871025A (en) Automated decoupling of RF receive coil elements
US11287493B2 (en) Magnetic resonance imaging method and system and computer-readable storage medium
JP5815384B2 (en) Magnetic resonance equipment
JP4912808B2 (en) Magnetic resonance imaging system
CN112748383A (en) Magnetic resonance imaging system and position display method
US9297867B2 (en) Radio frequncy (RF) body coil and method for tuning an RF body coil for magnetic resonance imaging
CN102370482B (en) Method for visualizing a lymph node and correspondingly embodied combined MR/PET apparatus
US10969449B2 (en) Local shimming system for magnetic resonance imaging and method thereof
JP5053725B2 (en) Magnetic resonance imaging system

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant