CN103550015A - Heart valve prosthesis valve frame and intervened heart valve prosthesis using valve frame - Google Patents
Heart valve prosthesis valve frame and intervened heart valve prosthesis using valve frame Download PDFInfo
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- CN103550015A CN103550015A CN201310535292.4A CN201310535292A CN103550015A CN 103550015 A CN103550015 A CN 103550015A CN 201310535292 A CN201310535292 A CN 201310535292A CN 103550015 A CN103550015 A CN 103550015A
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Abstract
The invention provides a heart valve prosthesis valve frame and an intervened heart valve prosthesis using the valve frame. The valve frame is a cylindrical framework which can be retracted and expanded in the radial direction and comprises an annular inlet layer and an outlet layer which are arranged along the axial direction of the cylindrical framework at an interval and in parallel, an annular middle layer which is arranged between the inlet layer and the outlet layer in parallel, and a plurality of connection beams which are uniformly distributed along the peripheral direction and are parallel to the axial direction of the cylindrical framework, wherein the connection beams penetrate through the middle layer to be connected with the inlet layer and the outlet layer and comprise three main connection beams which are uniformly distributed along the peripheral direction; each layer is respectively provided with a plurality of continuous V-shaped units which are formed by connecting supporting rods which are the same in length and mutually form angles end to end; the length of each supporting rod of the middle layer and the angle between the supporting rods are greater than those of the inlet layer and the outlet layer; the connection beams are connected with all the layers by end points or middle points of the supporting rods. According to the intervened heart valve prosthesis and the valve frame provided by the invention, the pressing diameter can be reduced, sufficient supporting forces are provided while an inner stress of the valve frame is reduced; the stopping of blood entering a coronary artery is reduced.
Description
Technical field
The intervention Cardiac valve prosthesis that the present invention relates to a kind of Cardiac valve prosthesis lobe frame and this lobe frame of employing, belongs to technical field of medical instruments.
Background technology
Valvular heart disease is one of cardiopathic main species at present, and valve disease can cause the great dysfunction of heart and finally need to be with the autologous cardiac valve of artificial cardiac valve replacement.For majority, need to change valvular patient, can adopt operating mode that Cardiac valve prosthesis is implanted.But the Srgery grafting of Cardiac valve prosthesis needs surgery open chest surgery conventionally, cardiac arrest during this period, patient carries out extracorporeal circulation by heart-lung machine.In operation process the needed time of extracorporeal circulation longer, patient's mortality risk is higher.Therefore a considerable amount of have the patient of valve defect can not undergo a surgical operation because health is too weak, as high-risk, advanced age with exist surgery to change the patient of lobe contraindication.
Due to the operating above-mentioned shortcoming of conventional Thoracotomy in Management, percutaneous is got involved the method for cardiac valve replacement and is shown great attention to.Get involved at present cardiac valve and be mainly divided into balloon-expandable and self-expansion type, all by conduit percutaneous, implant.Cardiac valve prosthesis is compressive state in conduit, then by airbag inflation or utilize self expandable principle to expand in desired location.Common intervention Cardiac valve prosthesis is comprised of lobe frame, the lobe impeller structure that comprises a plurality of lobe leaves and stitching skirt.Lobe frame 1 as shown in Figure 1, it is the cylindrical frame with entrance point 2 and the port of export 3, in order to guarantee support strength, adopting identical V-arrangement cellular construction to repeat multilamellar arranges, summit, V-arrangement unit between multilamellar is connected, and this makes embedded material too much, and density is larger.
Summary of the invention
The invention provides a kind of lobe frame of Cardiac valve prosthesis, after implantation, can when effective support force is provided, reduce diameter and the internal stress of lobe frame, reduce flowing into stopping of coronary flow.
The present invention also provides a kind of intervention Cardiac valve prosthesis that adopts above-mentioned lobe frame, there is in use higher-strength, can subtract the crimp of minor cusp, effective support is provided and reduces and flow into stopping of coronary flow, the structural stability of lobe leaf and stitching skirt is strong, can reduce the blood reflux of getting involved after Cardiac valve prosthesis is implanted.
The invention provides a kind of lobe frame of Cardiac valve prosthesis, described lobe frame is cylindrical frame radially collapsible and expansion, and it comprises:
Import layer and outlet layer, be arranged in parallel along the axially spaced-apart of described cylindrical frame, and respectively along the circumferential formation circular ring of described cylindrical frame;
Intermediate layer, is set in parallel between described import layer and outlet layer, and along the circumferential formation circular ring of described cylindrical frame;
Equally distributed many tie-beams along the circumferential direction, described many tie-beams respectively with the axially parallel of described cylindrical frame, and connect described import layer and outlet layer through described intermediate layer, and described tie-beam at least comprises along the circumferential direction equally distributed 3 main tie-beams;
Wherein, described import layer, outlet layer and intermediate layer have respectively the continuous V-arrangement unit being formed by a plurality of length pole joining end to end identical and at an angle to each other, the strut lengths that forms V-arrangement unit, intermediate layer is greater than the strut lengths of described import layer and outlet layer V-type unit, and the angle that described intermediate layer is connected between pole is greater than the angle that described import layer is connected between pole with outlet layer, and described tie-beam connects each layer by end points or the mid point of described pole.
Further, the width of described intermediate layer pole is more than or equal to the width of described import layer and outlet layer pole.
Further, described import layer and/or outlet layer are monolayer annulus or the double-layer circular ring that arranges along the axially parallel of described cylindrical frame.
Further, described import layer and/or outlet layer are double-layer circular ring, described double-layer circular ring comprises the first annulus portion and the second annulus portion, and the V-arrangement unit opening of the V-arrangement unit of described the first annulus portion and the second annulus portion at opposite position place is relative or arrange in the same way.
Further, it is relative that the V-arrangement unit of described the first annulus portion and the V-arrangement unit of the second annulus portion at opposite position place are opening, and described the first annulus portion is connected by the pole end points of V-arrangement unit opening with the second annulus portion.
Further, on described main tie-beam, have hole or groove, the width of described hole aperture or groove is 0.4-1.4mm.
Further, the pole that forms described intermediate layer has locating hole, and the aperture of described locating hole is 0.4-1.2mm.
Further, described many tie-beams also comprise three along the circumferential direction equally distributed secondary tie-beams.
Further, described import layer, intermediate layer and outlet layer are all connected with described tie-beam by described pole end points; Or described tie-beam connects described import layer and outlet layer by the pole mid point in described intermediate layer, and described tie-beam is connected with the pole end points of described import layer and outlet layer.
Further, the pole of described import layer is identical with the strut lengths of described outlet layer.
Further, in described import layer and/or outlet layer, between two adjacent described main tie-beams, there is 4-8 described V-arrangement unit.
Further, described cylindrical frame is in expansion state, and in described import layer and/or outlet layer, the angle between two poles of formation V-arrangement unit is 80-120 °.
Further, in described intermediate layer, between two adjacent described main tie-beams, there is 2-4 described V-arrangement unit.
Further, described cylindrical frame is in expansion state, and in described intermediate layer, the angle between two poles of formation V-arrangement unit is 90-140 °.
Further, the elliptic arc structure by a projection is connected between described pole and between described pole and described tie-beam, between elliptic arc and pole, adopts arc transition.
Further, described cylindrical frame is that tubing hollow out is formed, or cylindrical by being rolled into after sheet material hollow out.
The present invention also provides a kind of intervention Cardiac valve prosthesis, comprises above-mentioned lobe frame, and there is the lobe impeller structure of 3 lobe leaves and sew up skirt, wherein,
Described lobe impeller structure is arranged on the inside of described cylindrical frame, by stitching thread, is fixed main tie-beam and is sewed up on skirt;
Described lobe leaf is lamellar, has fan-shaped lower limb, and two lateral margins of lobe leaf are connected with two adjacent described main tie-beams respectively;
Described stitching skirt is along being circumferentially arranged between described cylindrical frame and described lobe impeller structure, and close with intermediate layer and import layered suture respectively at two ends, and the lower limb of lobe leaf is connected in the inner surface of sewing up skirt.
Further, the pole that forms described intermediate layer has locating hole, and described stitching skirt is connected with described intermediate layer by this locating hole.
Further, described tie-beam has hole, and described stitching skirt is connected with described tie-beam by this hole with lobe leaf.
The present invention program's enforcement, at least has following advantage:
1, lobe frame of the present invention is when being used less embedded material that effective support force is provided, and is beneficial to and reduces to press-fit diameter and press-fit and expand back lobe frame internal stress; And can effectively reduce after implantation flowing into stopping of coronary flow;
2, the valve that utilizes lobe frame of the present invention to make, can increase lobe leaf and sew up the stationkeeping ability of skirt and the stability of location in clinical practice, reduce and get involved circumferentially backflowing after valve implantation.
Accompanying drawing explanation
Fig. 1 is the lobe shelf structure schematic diagram of existing Cardiac valve prosthesis.
Fig. 2 is the perspective view of embodiment 1 mesopetalum frame.
Fig. 3 is expanded view along the circumferential direction after the main tie-beam center line A-A ' of along the frame of lobe shown in Fig. 2 cuts.
Fig. 4 is along expanded view along the circumferential direction after a main tie-beam midline incision of embodiment 2 mesopetalum framves.
Fig. 5 is along expanded view along the circumferential direction after a main tie-beam midline incision of embodiment 3 mesopetalum framves.
Fig. 6 a, Fig. 6 b, Fig. 6 c and Fig. 6 d are respectively in lobe frame provided by the invention between pole and the enforcement schematic diagram of the junction of pole and tie-beam.
Fig. 7 is along expanded view along the circumferential direction after a main tie-beam midline incision of embodiment 4 mesopetalum framves.
Fig. 8 is the artificial valvular perspective view of intervention provided by the invention.
The specific embodiment
The valve that the invention provides a kind of Cardiac valve prosthesis lobe frame and this lobe frame of use, when effective support force is provided, reduces the stress in lobe frame after implant into body, reduces flowing into stopping of coronary flow.This lobe frame is cylindrical frame radially collapsible and expansion, and it comprises: import layer and outlet layer, along the axially spaced-apart of described cylindrical frame, be arranged in parallel, and respectively along the circumferential formation circular ring of described cylindrical frame;
Intermediate layer, is set in parallel between described import layer and outlet layer, and along the circumferential formation circular ring of described cylindrical frame;
Equally distributed many tie-beams along the circumferential direction, described many tie-beams respectively with the axially parallel of described cylindrical frame, and connect described import layer and outlet layer through described intermediate layer, and described tie-beam at least comprises along the circumferential direction equally distributed 3 main tie-beams;
Wherein, described import layer, outlet layer and intermediate layer have respectively the continuous V-arrangement unit being formed by a plurality of length pole joining end to end identical and at an angle to each other, the strut lengths that forms V-arrangement unit, intermediate layer is greater than the strut lengths of described import layer and outlet layer V-type unit, and the angle that described intermediate layer is connected between pole is greater than the angle that described import layer is connected between pole with outlet layer, and described tie-beam connects each layer by end points or the mid point of described pole.
The blood of valve of flowing through enters valve through import layer, through outlet layer, flows out.Described import layer can be monolayer annulus or the double-layer circular ring arranging along the axially parallel of cylindrical frame.Above-mentioned double-layer circular ring comprises the first annulus portion and the second annulus portion, and it is relative or arrange in the same way that the V-arrangement unit of the first annulus portion and the V-arrangement unit of the second annulus portion at opposite position place are opening, this structure is conducive to, to sewing up the further fixing and support of skirt, in implantation, reduce afterwards the circumferential leakage by valve blood; And make import layer as one of main part of the force of support blood vessels, increase the support strength to blood vessel.
In specific embodiment, it is relative that the V-arrangement unit of the first annulus portion and the V-arrangement unit of the second annulus portion at opposite position place are opening, and the first annulus portion is connected by the pole end points of V-arrangement unit opening with the second annulus portion.In addition, tie-beam can also be arranged to the junction of the first annulus portion and the second annulus portion, make double-layer circular ring more harmonious when compression process neutralization provides support.
For outlet layer, can adopt identical structure with import layer.In specific embodiment, outlet layer can adopt monolayer annulus, and this structure can effectively increase the aperture area of blood flow import department lobe frame, reduces valve to flowing into stopping of coronary flow.
The strut lengths that forms import layer can be identical or different with the strut lengths and the width that form outlet layer, but be all less than the strut lengths that forms intermediate layer.
In the present invention, should consider the annulus number of plies of pole width or diameter, import layer and outlet layer and the material using etc., to meet the requirement to lobe frame intensity.For example, when higher to the requirement of strength of lobe frame, optionally increase pole width or thickness, the annulus number of plies, and the higher material of selection intensity.
On the pole in formation intermediate layer, can be provided with locating hole, for the fixing skirt of sewing up, the aperture of this locating hole can be 0.4-1mm; Also can adopt current routine without the structure of locating hole, by sewing up skirt, directly be sewn on the pole of closing on.
In specific embodiment, can adopt intermediate layer V-arrangement number of unit lower than import layer and outlet layer, and the width of its bar is greater than width or the diameter of import layer and outlet layer king-rod.This structure makes lobe frame when enough support strength is provided, has increased the area of the built on stilts gap of lobe, is conducive to reduce to the stopping of blood flow, simultaneously wider bar location hole that makes can arrange easily on it.
In the present invention, tie-beam connects each layer by end points or the mid point of pole, for example, import layer, intermediate layer and outlet layer all can be connected with tie-beam by pole end points, or tie-beam connects import layer and outlet layer by the mid point of intermediate layer pole, and tie-beam is connected with the end points (being the summit of V-arrangement unit) of import layer and outlet layer pole.
Above-mentioned tie-beam, except comprising 3 main tie-beams, can also comprise many along the circumferential direction uniform secondary tie-beams.Main tie-beam is for connecting the lobe impeller structure of getting involved valve, and its width or diameter are equal to or greater than other secondary tie-beam not directly being connected with lobe impeller structure.In order to sew up with lobe impeller structure more easily, on main tie-beam, can also be provided with hole or elongate slot, the aperture of hole or the width of groove are 0.4-1.4mm conventionally.
The material category that lobe frame in the present invention, lobe impeller structure and stitching skirt are used can be with reference to prior art, and wherein, the material that lobe frame material is plastically deformable, such as using medical Nitinol, cochrome, rustless steel etc.; Lobe leaf can be used animal pericardium material, or animal valve, as bovine pericardium, and porcine aorta valve; Sew up skirt and can use dacron fabric etc.
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is described.
Embodiment 1
The present embodiment provides a kind of lobe frame 100 of Cardiac valve prosthesis.Fig. 2 is the perspective view of this lobe frame 100.Fig. 3 is expanded view along the circumferential direction after the main tie-beam 401 center line A-A ' of along the frame of lobe shown in Fig. 1 100 cut.As shown in Figures 2 and 3, this lobe frame is cylindrical frame 100 radially collapsible and expansion, can be by tubing hollow out be formed, and also can be cylindrical by being rolled into after sheet material hollow out.This lobe frame 100 comprises: the circular import layer 10 arranging to top spaced and parallel from bottom, and intermediate layer 20 and outlet layer 30, wherein import layer 10 and outlet layer 30 are for limiting the blood flow direction of the valve of flowing through; Intermediate layer 20 is set in parallel between import layer 10 and outlet layer 30, provides support power; And equally distributed many tie-beams along the circumferential direction, its respectively with the axially parallel of cylindrical frame 100, and tie-beam 401-406 connects import layer 10 and outlet layers 30 through intermediate layer 20.
As shown in Figures 2 and 3, the tie-beam that connects import layer 10, intermediate layer 20 and outlet layer 30 has six 401-406, wherein tie-beam 401,403,405 is main tie-beam, all the other can be described as secondary tie-beam, main tie-beam 401,403,405 is in the circumferencial direction 120 ° of symmetric arrays of being separated by, and its width (along the circumferential direction) is greater than other three secondary tie-beams.The main tie-beam of whole piece keeps the width of homogeneous, flushes with the top that forms the V-arrangement unit of outlet layer 30, is beneficial to lobe frame and sews up with less axial length and lobe impeller structure.Article three, main tie-beam is provided with the hole 41 that some apertures are 0.8mm, for connect get involved valve lobe leaf 50(in conjunction with shown in Fig. 7).
Import layer 10, intermediate layer 20 and outlet layer 30 are monolayer circular ring structure.The strut lengths that forms intermediate layer 20 is greater than the strut lengths that forms import layer 10 and outlet layer 30, and therefore, between adjacent two main tie-beams, the V-arrangement unit that forms import layer 10 and outlet layer 30 respectively has 4, and the V-arrangement unit that forms intermediate layer 20 has 2.Between main tie-beam and the secondary tie-beam that is adjacent, the V-arrangement unit that forms import layer 10 and outlet layer 30 respectively has 2, and the V-arrangement unit that forms intermediate layer 20 only has 1.In order to be more conducive to the radial contraction of implantation process mesopetalum frame 100, lobe frame 100 is under expansion state, and for import layer 10 and outlet layer 30, between adjacent struts, angle is 80-120 °, and for intermediate layer 20, the angle between adjacent struts is 90-140 °.On the bar of the v-shaped structure in intermediate layer 20, only have that on the bar adjacent with main tie-beam, to have aperture be the locating hole 21 of 0.6mm, can be used for fixing skirt 300 and the lobe leaf 50(of sewing up in conjunction with shown in Fig. 7).
In the present embodiment, the material that lobe frame is used that is arranged so that in intermediate layer 20 reduces.Therefore the lobe frame 100 that the present embodiment provides can be when providing effective support force, minimizing is to flowing into stopping of coronary flow, arranging of hole 41 and locating hole 21 can increase lobe leaf 50 and sew up the stationkeeping ability of skirt 300 and the stability of location, reduces the blood reflux (shown in Fig. 7) of getting involved after valve 400 is implanted.
As shown in Figure 4, the lobe frame 100 that the present embodiment provides is basic identical with the structure in embodiment 1.Difference is, outlet layer 30 and intermediate layer 20 are monolayer annulus, and import layer 10 is double-layer circular ring, have the first annulus portion 11 and the second annulus portion 12, the opening of its V-arrangement unit is relative, and the first annulus portion 11 is not connected with the summit, V-arrangement unit at the second annulus portion 12 opposite position places.This structure is conducive to sewing up the further fixing of skirt 300, is reduced in rear reduction of implantation and passes through the circumferential leakage of valve blood after implantation; And make import layer 10 as one of main part of the force of support blood vessels, increase the support strength to blood vessel; Increase the aperture area of blood flow import department simultaneously, reduce flowing into stopping of coronary flow.
As shown in Figure 4, the tie-beam that connects import layer 10, intermediate layer 20 and outlet layer 30 has six 401-406, wherein 401,403,405 is main tie-beam, all the other are secondary tie-beam, main tie-beam 401,403,405 is in the circumferencial direction 120 ° of symmetric arrays of being separated by, its width or diameter are greater than other three company's pairs and connect beam, have the elongated slot 42 of 0.8mm on main tie-beam, for the fixing lobe leaf 50 of getting involved valve.In order to reduce embedded material, main tie-beam is the width of the part of trough of belt 42 or the part that diameter can be less than trough of belt 42 not.
As shown in Figure 5, the lobe frame 100 that the present embodiment provides is basic identical with the structure in embodiment 2.Difference is, the first annulus portion 11 is connected with the summit, V-arrangement unit at the second annulus portion 12 opposite position places.Fig. 6 d is the tie-beam 406 of Fig. 5 mesopetalum frame and the enlarged drawing of the junction c of above-mentioned the first annulus portion 11 and the second annulus portion 12.As shown in Fig. 6 d, when tie-beam 406 is connected with the second annulus portion 12 with the first annulus portion 11, the elliptic arc structure of junction projection forms M shape structure and Y-shaped structure.When 100 compressions of lobe frame are installed, it is parallel more harmonious that the structure that this double-layer circular ring connects is conducive to double-layer circular ring.
Each pole that forms intermediate layer 20 is provided with the hole that an aperture is 0.6mm, and it is for the fixing position of sewing up skirt 300 and further fixed lobes leaf 50.
In addition, in the present embodiment, the width that forms the bar in intermediate layer 20 is greater than the pole that forms import layer 10 and outlet layer 30, and this structure is beneficial to provides better support effect.
Embodiment 4
As shown in Figure 7, the lobe frame 100 that the present embodiment provides is basic identical with the structure in embodiment 1.Difference is, tie-beam 401-406 structure is identical, is the beam of not establishing hole or groove.In addition, tie-beam 401-406 connects import layer 10 and outlet layer 30 by the mid point of intermediate layer 20 poles, the relative arrangement in V-arrangement unit of import layer 10 and outlet layer 30, and end points (being the summit of the V-arrangement unit) point of tie-beam 401-406 and import layer 10 and pole in outlet layer 30 is connected.
Embodiment 5
The present embodiment provides a kind of intervention Cardiac valve prosthesis 400.As shown in Figure 8, this valve comprises the cylindrical frame 100 in embodiment 1, the lobe impeller structure 200 with 3 lobe leaves and stitching skirt 300.Lobe impeller structure 200 is arranged on the inside of cylindrical frame 100, has the shape similar to physiology lobe leaf, by stitching thread 60, is fixed on intermediate layer 20 and main tie-beam 401,403,405.In the present embodiment, each lobe leaf 50 is lamellar, has fan-shaped lower limb, and two lateral margins of lobe leaf 50 are sewn to respectively on the hole 41 of adjacent two main tie-beams 403 and 405.Sew up skirt 300 along being circumferentially arranged between cylindrical frame 100 and lobe impeller structure 200, upper and lower two ends are sewed up with intermediate layer 20 and import layer 10 respectively.Sew up skirt 300 and upwards can sew up with tie-beam hole 41 in week, and can further by locating hole 21 and intermediate layer 20, sew up, play further fixing effect, and the lower limb of lobe leaf 50 is connected in the inner surface of sewing up skirt 200.
The intervention Cardiac valve prosthesis 400 that the present embodiment provides can reduce in use to flowing into stopping of coronary flow, and the structural stability of lobe leaf 50 and stitching skirt 200 is strong, can reduce the blood reflux of getting involved after Cardiac valve prosthesis 400 is implanted.
Finally it should be noted that: each embodiment, only in order to technical scheme of the present invention to be described, is not intended to limit above; Although the present invention is had been described in detail with reference to aforementioned each embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record aforementioned each embodiment is modified, or some or all of technical characterictic is wherein equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
Claims (19)
1. a lobe frame for Cardiac valve prosthesis, is characterized in that, described lobe frame is cylindrical frame radially collapsible and expansion, and it comprises:
Import layer and outlet layer, be arranged in parallel along the axially spaced-apart of described cylindrical frame, and respectively along the circumferential formation circular ring of described cylindrical frame;
Intermediate layer, is set in parallel between described import layer and outlet layer, and along the circumferential formation circular ring of described cylindrical frame;
Equally distributed many tie-beams along the circumferential direction, described many tie-beams respectively with the axially parallel of described cylindrical frame, and connect described import layer and outlet layer through described intermediate layer, and described tie-beam at least comprises along the circumferential direction equally distributed 3 main tie-beams;
Wherein, described import layer, outlet layer and intermediate layer have respectively continuous V-arrangement unit, described continuous V-arrangement unit is formed by a plurality of length pole joining end to end identical and at an angle to each other, the strut lengths that forms V-arrangement unit, intermediate layer is greater than the strut lengths of described import layer and outlet layer V-type unit, and the angle that described intermediate layer is connected between pole is greater than the angle that described import layer is connected between pole with outlet layer, and described tie-beam connects each layer by end points or the mid point of described pole.
2. lobe frame according to claim 1, is characterized in that, the width of described intermediate layer pole is more than or equal to the width of described import layer and outlet layer pole.
3. lobe frame according to claim 1, is characterized in that, described import layer and/or outlet layer are monolayer annulus or the double-layer circular ring that arranges along the axially parallel of described cylindrical frame.
4. lobe frame according to claim 3, it is characterized in that, described import layer and/or outlet layer are double-layer circular ring, described double-layer circular ring comprises the first annulus portion and the second annulus portion, and to be opening relative or arrange in the same way the V-arrangement unit of described the first annulus portion and the V-arrangement unit of the second annulus portion at opposite position place.
5. lobe frame according to claim 4, it is characterized in that, it is relative that the V-arrangement unit of described the first annulus portion and the V-arrangement unit of the second annulus portion at opposite position place are opening, and described the first annulus portion is connected by the pole end points of V-arrangement unit opening with the second annulus portion.
6. lobe frame according to claim 1, is characterized in that, on described main tie-beam, has hole or groove, and the aperture of described hole or the width of groove are 0.4-1.4mm.
7. lobe frame according to claim 1, is characterized in that, the pole that forms described intermediate layer has locating hole, and the aperture of described locating hole is 0.4-1.2mm.
8. lobe frame according to claim 1, is characterized in that, described many tie-beams also comprise three along the circumferential direction equally distributed secondary tie-beams.
9. according to the lobe frame described in claim 1-8 any one, it is characterized in that, described import layer, intermediate layer and outlet layer are all connected with described tie-beam by described pole end points; Or described tie-beam connects described import layer and outlet layer by the pole mid point in described intermediate layer, and described tie-beam is connected with the pole end points of described import layer and outlet layer.
10. lobe frame according to claim 1, is characterized in that, the pole of described import layer is identical with the strut lengths of described outlet layer.
11. lobe framves according to claim 10, is characterized in that, in described import layer and/or outlet layer, have 4-8 described V-arrangement unit between two adjacent described main tie-beams.
12. according to the lobe frame described in claim 10 or 11, it is characterized in that, described cylindrical frame is in expansion state, and in described import layer and/or outlet layer, the angle between two poles of formation V-arrangement unit is 80-120 °.
13. according to the lobe frame described in claim 1 or 11, it is characterized in that, in described intermediate layer, has 2-4 described V-arrangement unit between two adjacent described main tie-beams.
14. lobe framves according to claim 13, is characterized in that, described cylindrical frame is in expansion state, and in described intermediate layer, the angle between two poles of formation V-arrangement unit is 90-140 °.
15. lobe framves according to claim 1, is characterized in that, the elliptic arc structure by a projection is connected between described pole and between described pole and described tie-beam, between described elliptic arc and described pole, adopts arc transition.
16. lobe framves according to claim 1, is characterized in that, described cylindrical frame is that tubing hollow out is formed, or cylindrical by being rolled into after sheet material hollow out.
17. 1 kinds of intervention Cardiac valve prosthesiss, is characterized in that, described intervention Cardiac valve prosthesis comprises the lobe frame described in claim 1-16 any one, also comprise and there is the lobe impeller structure of 3 lobe leaves and sew up skirt, wherein,
Described lobe impeller structure is arranged on the inside of described cylindrical frame, by stitching thread, is fixed main tie-beam and is sewed up on skirt;
Described lobe leaf is lamellar, has fan-shaped lower limb, and two lateral margins of lobe leaf are connected with two adjacent described main tie-beams respectively;
Described stitching skirt is along being circumferentially arranged between described cylindrical frame and described lobe impeller structure, and close with intermediate layer and import layered suture respectively at two ends, and the lower limb of lobe leaf is connected in the inner surface of sewing up skirt.
18. intervention Cardiac valve prosthesiss according to claim 17, is characterized in that, the pole that forms described intermediate layer has locating hole, and described stitching skirt is connected with described intermediate layer by this locating hole.
19. according to the intervention Cardiac valve prosthesis described in claim 17 or 18, it is characterized in that, described tie-beam has hole, and described stitching skirt is connected with described tie-beam by this hole with lobe leaf.
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| CN201310535292.4A CN103550015B (en) | 2013-11-01 | 2013-11-01 | Heart valve prosthesis valve frame and intervened heart valve prosthesis using valve frame |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104720937A (en) * | 2015-03-26 | 2015-06-24 | 杭州启明医疗器械有限公司 | Valve support for decreasing compression length and valve replacement device with valve support |
| CN105342725A (en) * | 2015-11-27 | 2016-02-24 | 金仕生物科技（常熟）有限公司 | Artificial biological heart valve stent and artificial biological heart valve |
| WO2018121341A1 (en) * | 2016-12-30 | 2018-07-05 | 先健科技(深圳)有限公司 | Heart valve prosthesis device and leaflet and stent body thereof |
| CN109688941A (en) * | 2016-08-11 | 2019-04-26 | 4C医学技术有限公司 | For keeping, supplementing and/or replacing the heart chamber prosthetic valve implantation piece with raising valve section and single chamber anchoring of native valve function |
| WO2019196845A1 (en) * | 2018-04-09 | 2019-10-17 | 倍芮医疗器械（上海）有限公司 | Venous valve replacement device |
| EP3107500B1 (en) | 2014-02-18 | 2021-11-24 | Edwards Lifesciences Corporation | Flexible commissure frame |
| WO2022078525A1 (en) * | 2020-10-12 | 2022-04-21 | 金仕生物科技（常熟）有限公司 | Interventional mitral valve stent |
| WO2023087817A1 (en) * | 2021-11-16 | 2023-05-25 | 上海臻亿医疗科技有限公司 | Prosthetic heart valve |
| US11969340B2 (en) | 2022-03-28 | 2024-04-30 | Edwards Lifesciences Corporation | Flexible commissure frame |
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| EP4091581B1 (en) * | 2014-02-18 | 2023-12-27 | Edwards Lifesciences Corporation | Flexible commissure frame |
| US20220218477A1 (en) * | 2014-02-18 | 2022-07-14 | Edwards Lifesciences Corporation | Flexible commissure frame |
| EP3107500B1 (en) | 2014-02-18 | 2021-11-24 | Edwards Lifesciences Corporation | Flexible commissure frame |
| US11957574B2 (en) * | 2014-02-18 | 2024-04-16 | Edwards Lifesciences Corporation | Flexible commissure frame |
| EP4285866A3 (en) * | 2014-02-18 | 2024-02-28 | Edwards Lifesciences Corporation | Flexible commissure frame |
| EP4285867A3 (en) * | 2014-02-18 | 2024-02-28 | Edwards Lifesciences Corporation | Flexible commissure frame |
| EP4275656A3 (en) * | 2014-02-18 | 2024-01-31 | Edwards Lifesciences Corporation | Flexible commissure frame |
| CN104720937A (en) * | 2015-03-26 | 2015-06-24 | 杭州启明医疗器械有限公司 | Valve support for decreasing compression length and valve replacement device with valve support |
| CN105342725B (en) * | 2015-11-27 | 2017-11-03 | 金仕生物科技（常熟）有限公司 | Artificial biological heart valve support and artificial biological heart valve |
| CN105342725A (en) * | 2015-11-27 | 2016-02-24 | 金仕生物科技（常熟）有限公司 | Artificial biological heart valve stent and artificial biological heart valve |
| CN109688941A (en) * | 2016-08-11 | 2019-04-26 | 4C医学技术有限公司 | For keeping, supplementing and/or replacing the heart chamber prosthetic valve implantation piece with raising valve section and single chamber anchoring of native valve function |
| CN109688941B (en) * | 2016-08-11 | 2021-10-15 | 4C医学技术有限公司 | Heart chamber prosthetic valve implants with elevated valve sections and single chamber anchoring for maintaining, supplementing and/or replacing native valve function |
| CN108261255A (en) * | 2016-12-30 | 2018-07-10 | 先健科技(深圳)有限公司 | Artificial heart valve film device and its leaflet and rack body |
| WO2018121341A1 (en) * | 2016-12-30 | 2018-07-05 | 先健科技(深圳)有限公司 | Heart valve prosthesis device and leaflet and stent body thereof |
| CN108261255B (en) * | 2016-12-30 | 2020-12-25 | 先健科技(深圳)有限公司 | Artificial heart valve device and valve leaf and support main body thereof |
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| US11969340B2 (en) | 2022-03-28 | 2024-04-30 | Edwards Lifesciences Corporation | Flexible commissure frame |
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