CN103284774A - Gas-injection thrombosis-removal device and application thereof - Google Patents
Gas-injection thrombosis-removal device and application thereof Download PDFInfo
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- CN103284774A CN103284774A CN2013101913525A CN201310191352A CN103284774A CN 103284774 A CN103284774 A CN 103284774A CN 2013101913525 A CN2013101913525 A CN 2013101913525A CN 201310191352 A CN201310191352 A CN 201310191352A CN 103284774 A CN103284774 A CN 103284774A
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Abstract
The invention discloses a gas-injection thrombosis-removal device and application thereof. The gas-injection thrombosis-removal device comprises a thrombolysis catheter, a guide string, a gas pump and a suction pump. Gas-injection holes and suction holes are distributed on the front portion of the thrombolysis catheter, the gas-injection holes are communicated with gas injection channels, the suction holes are communicated with suction channels, and gas supplied by the gas pump is carbon dioxide. The gas pump fills gas into the gas injection channels in a high-frequency pulse manner, the gas is rapidly injected from the gas injection holes to smash thrombosis to be easily sucked out or to become loose to be quickly dissolved by thrombolysis medicines.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, in particular to a kind of jet except pin device.
Background technology
(venous thrombosis VTE) refers at venous blood flow slowly phlebothrombosis, and under high blood coagulation state and the tunica intima damage condition, acute nonsuppurative inflammation takes place vein, and the disease that forms of secondary thrombus.It comprises pulmonary thromboembolism and venous thrombosis, and foreign data shows that its sickness rate accounts for the 3rd in cardiovascular system diseases, be only second to coronary heart disease and apoplexy.Most venous thrombosis occur in the dark vein of pelvic cavity and lower limb.After being more common in major operation or wound, long-term bed, limb brake, late tumor patient.
Deep venous thrombosis (deep venous thrombosis is clinical common disease DVT), behind the deep venous thrombosis of lower limbs, and sick lower limb vein rest pain, easy concurrent eczema of later stage, cutaneous pigmentation, venous ulcer etc., severe patient disability.Can flow to pulmonary artery with blood after thrombosis comes off, cause pulmonary infarction, wherein 50%～60% DVT patient can take place pulmonary thromboembolism (pulmonary thromboembolism, PTE), the serious harm human health.Other has bibliographical information, goes to a doctor in the thrombosis 12h, and therapeutic effect is best, and mortality rate is low, and the limbs disturbance incidence rate is low;＞3d goes to a doctor, case fatality rate height, limbs disturbance incidence rate height.So deep venous thrombosis has serious threat to patient's health and lives, need the instant thrombosis of removing.
The traditional therapy of DVT is at present: surgical operation is got bolt, internal medicine treatment and interventional minimally-invasive treatment.Surgical operation therapy is not widely accepted as yet, its main cause is that deep venous thrombosis is got the high Gu of bolt operation back recurrence rate, popliteal phlebothrombosis to get clean rate low, the danger of pulmonary embolism (PE) is arranged in the art, operation risk is big, wound is big, and especially get and cause the tunica intima of vein damage in the bolt process, often be the one of the main reasons that causes the thrombosis recurrence.Roder followed up a case by regular visits to 10 years after reporting 46 routine ilium femoral vein thrombosis embolectomies, 40% no any symptom wherein, and 27% still has and suffers from the limb mild swelling, and 33% limbs still have obvious swelling.So surgical operation is got bolt can not fine solution thrombosis problem.
Internal medicine treatment mainly comprises anticoagulant therapy and thromboembolism treatment.In anticoagulant therapy, often use unfractionated heparin, Low molecular heparin, the order of method China.Urokinase, streptokinase, rt-PA etc. belong to thrombolytic drug, can directly promote plasminogen to transfer fibrinolysin to, and fibrinolysin is raise rapidly, impel fibrin degradation, produce fibrin degradation product (FDP) (FDP), thus thrombus.If thrombolytic drug consumptions such as urokinase too much will cause hemorrhage risk to increase, it is hemorrhage to cause important organs such as head, digestive tract, but the severe patient threat to life.Thrombolytic drug for the fresh thrombus therapeutic effect of acute stage still can, treat subacute and old thrombosis weak effect.
Get with respect to surgical operation that bolt has a big risk, the medical treatment effective percentage is low, interventional minimally-invasive treatment has advantages such as complication such as wound is little, effective percentage is high, hemorrhage are low.At present the interventional minimally-invasive treatment thrombosis comprise insert IVCF, mechanical thrombus smash suction art, local veins indwelling catheter thromboembolism treatment to pieces, through methods such as catheter-based ultrasound ablations.
Wherein the many side openings thrombolysis catheter thrombolytic art in the interventional minimally-invasive treatment thrombosis has following advantage and is used widely in clinical, and the people that 1. the is situated between wound of performing the operation is little, reduces unexpected risks such as cardiovascular and cerebrovascular vessel.2. do not need to cut, sew up blood vessel, reduce the vascular restenosis risk.3. through conduit local injection thrombolytic drug, the thrombolytic drug consumption is low, can obviously reduce the risk of massive hemorrhage.4. can find that the blood vessel limitation is narrow under the intervention condition, handle together.
Usually adopt the venothrombotic treatment situation of following standard evaluation clinically.The I level: suffer from limb pain and the complete obiteration of swelling symptom, it is normal that Pi Wen and the colour of skin etc. are recovered, and color doppler ultrasonography demonstration deep venous thrombosis is dissolved fully, and the dark wall of vein of suffering from limb is smooth, and it is normal that bore recovers.The II level: the lower limb distending pain can occur after standing for a long time, lower extremity swelling and distension is eliminated substantially or is significantly alleviated, and it is normal that Pi Wen recovers, slight pigmentation is arranged on the skin, color doppler ultrasonography shows that deep venous thrombosis is partly dissolved, and the dark vein of suffering from limb has blood flow signal, and dark wall of vein is rough.The III level: suffer from limb distending pain and swelling and alleviate, color doppler ultrasonography shows that deep venous thrombosis reduces, and the deep vein stream of suffering from limb weakens.The IV level: it is obvious to suffer from the limb distending pain, and swelling does not alleviate, and color doppler ultrasonography shows the deep venous thrombosis no change.Suffer from the limb vein and do not have blood flow signal.I level and II level are produce effects, and the III level is for taking a turn for the better, and the IV level is invalid.
Above-mentioned anticoagulant, thrombolytic drug are in removing the process of bolt, and its side effect meeting increases the patient's bleeding risk, and causes complication such as other internal organs are hemorrhage.The more big patient's risk of bleeding of the consumption of above-mentioned anticoagulant, thrombolytic drug is more big.So the consumption of anticoagulant, thrombolytic drug will lack as much as possible, to reduce this type of medicine brings untoward reaction to patient risk.
Summary of the invention
At the deficiencies in the prior art, the invention provides a kind of jet except pin device, by the jet thrombosis that washes away, cause the thrombosis internal structure loosening, make the easier thrombosis inside that enters of urokinase, increase the contact area of medicine and thrombosis, thereby reduce drug dose and action time.
The jet pin device that removes of the present invention comprises: thrombolysis catheter, guiding wire, gas pump and suction pump, wherein thrombolysis catheter comprises two passages, outer tunnel is that its diameter of suction channel is 7～8F, internal channel is that its diameter of jet channel is 4～5F, jet channel and suction channel are coaxial, also have guiding wire in jet channel.The total length of thrombolysis catheter is 120～160cm, wherein remove the bolt live part in the thrombolysis catheter front portion, the diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the fumarole of 0.5～0.6mm, and the quantity of fumarole is 10-16, fumarole is distributed in the thrombolysis catheter both sides, every side 5-8.The diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the suction socket of 1.5～1.6mm, and the quantity of suction socket is 10-16, and suction socket is distributed in the thrombolysis catheter both sides, and every side 5-8, fumarole and the suction socket of every side are alternately distributed.Fumarole communicates with jet channel, and suction socket communicates with suction channel.
Jet thrombolysis catheter afterbody except pin device of the present invention has 4 interfaces, and wherein No. 1 interface links to each other with suction pump, and No. 2 interfaces are feeding opening, and No. 3 interface links to each other with gas pump, and No. 4 interfaces are the seal wire entrance.Wherein No. 1 interface communicates with suction channel, and No. 2, No. 3 and No. 4 interfaces communicate with jet channel.Link to each other with gas pump with suction pump respectively by screw knob with No. 3 interfaces for No. 1.No. 2 interface contains screw thread, is connected with syringe or drug efflux pump by threaded knob, and No. 4 interface contains screw thread, and the guiding wire of No. 4 seams passes a threaded knob, and this knob links to each other with No. 4 interfaces by screw thread.
The pressure of above-mentioned gas pump ejection gas is 100～200KPa, sprays 1 time every 0.5s, and each injecting time is 0.5s, and every injection 10-30 second, suction pump starts suction 10-30 second.Gas in the gas pump is carbon dioxide.
Above-mentioned jet except pin device in use, at first determine the position of thrombosis in the vein by the phlebography technology, under the guiding of guiding wire, thrombolysis catheter delivered to the thrombolytic place.Thrombolysis catheter is inserted in the thrombosis, No. 1 interface is linked to each other with gas pump, No. 3 interface links to each other with suction pump, No. 2 and the sealing of No. 4 interfaces, and gas pump pulsed inflation in the jet channel, gas sprays from fumarole rapidly, washes away thrombosis.Thrombosis washes away through the high frequency of gas, loosening, crack occurs and comes off with the broken [of trace, and suction pump starts the small thrombosis that suction comes off.The broken [that comes off is in time removed in gas pump and suction pump alternation as previously mentioned, makes that medicine is easier to be entered thrombosis inside along slight crack and carry out thrombolytic.It is tens of second that each position is washed away, and mobile thrombolysis catheter carries out aforesaid operations again, through behind the air scour number minute, closes gas pump and suction pump.Open interface No. 3, get syringe and be attached thereto.Get thrombolytic drug and be dissolved in the normal saline, in gained liquid gradation suction syringe, pressurized impulse injection in the thrombolysis catheter jet channel, namely be interrupted the pressurization administration, each vasopressing injection appropriate amount of drug, at interval the several seconds, repetitive operation is also observed the variation of patient respiratory pulse.Behind above-mentioned gas pulse and thrombolytic drug thrombolytic, the intravascular radiography detects thrombolytic situation in the blood vessel.
The above-mentioned jet pin device that removes has the following advantages:
1) by the high-frequency impulse of gas pump gas, endovascular thrombosis is washed away loosening, easily further thrombolytic.
2) the fumarole quantity of thrombolysis catheter front portion is many, and be evenly distributed, make the gas of gas pump ejection act on thrombosis uniformly, and wash away down at high frequency, slight crack appears in the thrombosis of fumarole contact, be conducive to urokinase and enter the thrombosis depths along slight crack, thereby arrival is by the urokinase of less amount, play maximum thrombolytic effect, reduce urokinase and cause hemorrhage side effect.
3) because the fumarole quantity of thrombolysis catheter front portion is many, and be evenly distributed on the outer wall of thrombolysis catheter, the fumarole of thrombolysis catheter front portion is embedded in the thrombosis during thrombolytic, and the gas load of fumarole ejection is even, and thrombosis is slided along the blood vessel access direction.
4) the broken [that comes off can be in time removed in gas pump and suction pump alternation, makes that medicine is easier to be entered thrombosis inside along slight crack and carry out thrombolytic.Since fresh thrombus easier by this device towards broken, so the described jet pin device that removes of the present invention is higher to the elimination efficiency of fresh thrombus.
Description of drawings
Fig. 1 is the jet structural representation except pin device of the present invention.
The rip cutting figure of Fig. 2 thrombolysis catheter.
The specific embodiment
Embodiment 1
, be described further of the present invention jet except pin device below in conjunction with accompanying drawing.
The jet pin device that removes of the present invention comprises: thrombolysis catheter 1, guiding wire 2, suction pump 3 and gas pump 4, wherein thrombolysis catheter comprises two passages, outer tunnel is that suction channel 17 its diameters are 8F, internal channel is that jet channel 18 its diameters are 4F, suction channel 17 and jet channel 18 are coaxial, also have guiding wire 2 in jet channel.The total length of thrombolysis catheter is 120cm, wherein remove the bolt live part in the thrombolysis catheter front portion, the diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the fumarole 11 of 0.5mm, and fumarole 11 is distributed in the both sides of thrombolysis catheter, and the quantity of every side fumarole is 5.The diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the suction socket 12 of 1.5mm, and suction socket 12 is distributed in the both sides of thrombolysis catheter, and the quantity of every side suction socket 12 is 5, and fumarole 11 and suction socket 12 are alternately distributed.Fumarole 11 communicates with jet channel 18, and suction socket 12 communicates with suction channel 17.
The jet thrombolysis catheter afterbody except pin device of the present invention has 4 interfaces, and wherein No. 1 interface 13 links to each other with suction pump 3, and No. 2 interface 14 is feeding opening, and No. 3 interface 15 links to each other with gas pump 4, and No. 4 interface 16 is the seal wire entrance.Wherein No. 1 interface communicates with suction channel 17, and No. 2, No. 3 and No. 4 interfaces communicate with jet channel 18.Link to each other with gas pump with suction pump respectively by screw knob with No. 3 interfaces for No. 1.No. 2 interface contains screw thread, is connected with syringe or drug efflux pump by threaded knob, and No. 4 interface contains screw thread, and the guiding wire of No. 4 seams passes a threaded knob, and this knob links to each other with No. 4 interfaces by screw thread.
The pressure of above-mentioned gas pump ejection gas is 100～200KPa, sprays 1 time every 0.5s, and each injecting time is 0.5s, and every injection 10-30 second, suction pump starts suction 10-30 second.Gas in the gas pump is carbon dioxide.
Embodiment 2
The jet pin device that removes of the present invention comprises: thrombolysis catheter 1, guiding wire 2, suction pump 3 and gas pump 4, wherein thrombolysis catheter comprises two passages, outer tunnel is that suction channel 17 its diameters are 8F, internal channel is that jet channel 18 its diameters are 5F, suction channel 17 and jet channel 18 are coaxial, also have guiding wire 2 in jet channel.The total length of thrombolysis catheter is 120cm, wherein remove the bolt live part in the thrombolysis catheter front portion, the diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the fumarole 11 of 0.6mm, and fumarole 11 is distributed in the both sides of thrombolysis catheter, and the quantity of every side fumarole is 5.The diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the suction socket 12 of 1.6mm, and suction socket 12 is distributed in the both sides of thrombolysis catheter, and the quantity of every side suction socket 12 is 5, and fumarole 11 and suction socket 12 are alternately distributed.Fumarole 11 communicates with jet channel 18, and suction socket 12 communicates with suction channel 17.The other parts structure of air jet system of the present invention is with embodiment 1.
The jet pin device that removes of the present invention comprises: thrombolysis catheter 1, guiding wire 2, suction pump 3 and gas pump 4, wherein thrombolysis catheter comprises two passages, outer tunnel is that suction channel 17 its diameters are 8F, internal channel is that jet channel 18 its diameters are 5F, suction channel 17 and jet channel 18 are coaxial, also have guiding wire 2 in jet channel.The total length of thrombolysis catheter is 120cm, wherein remove the bolt live part in the thrombolysis catheter front portion, the diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the fumarole 11 of 0.6mm, and fumarole 11 is distributed in the both sides of thrombolysis catheter, and the quantity of every side fumarole is 8.Being uniform-distribution with diameter in the 0.5～10cm scope of thrombolysis catheter front portion is the suction socket 12 of 1.6mm, and suction socket 12 is distributed in the both sides of thrombolysis catheter, and the quantity of every side suction socket 12 is 8, and fumarole 11 and suction socket 12 are alternately distributed.Fumarole 11 communicates with jet channel 18, and suction socket 12 communicates with suction channel 17.The other parts structure of air jet system of the present invention is with embodiment 1.
The jet pin device that removes of the present invention comprises: thrombolysis catheter 1, guiding wire 2, suction pump 3 and gas pump 4, wherein thrombolysis catheter comprises two passages, outer tunnel is that suction channel 17 its diameters are 7F, internal channel is that jet channel 18 its diameters are 4F, suction channel 17 and jet channel 18 are coaxial, also have guiding wire 2 in jet channel.The total length of thrombolysis catheter is 120cm, wherein remove the bolt live part in the thrombolysis catheter front portion, the diameter that distributing in the 0.5～10cm scope of thrombolysis catheter front portion is the fumarole 11 of 0.5mm, and fumarole 11 is distributed in the both sides of thrombolysis catheter, and the quantity of every side fumarole is 8.Being uniform-distribution with diameter in the 0.5～10cm scope of thrombolysis catheter front portion is the suction socket 12 of 1.5mm, and suction socket 12 is distributed in the both sides of thrombolysis catheter, and the quantity of every side suction socket 12 is 8, and fumarole 11 and suction socket 12 are alternately distributed.Fumarole 11 communicates with jet channel 18, and suction socket 12 communicates with suction channel 17.The other parts structure of air jet system of the present invention is with embodiment 1.
Embodiment 5 air jet system usings method
Above-mentioned jet except pin device in use, at first determine the position of thrombosis in the vein by the phlebography technology, under the guiding of guiding wire, thrombolysis catheter delivered to the thrombolytic place.Thrombolysis catheter is inserted in the thrombosis, No. 1 interface is linked to each other with suction pump, and No. 3 interface links to each other with gas pump, No. 2 and No. 4 interface sealings, gas pump is the pulsed inflation in the jet channel, gas sprays from fumarole rapidly, washes away thrombosis, and the pressure of gas pump ejection gas is 100～200KPa, spray 1 time every 0.5s, each injecting time is 0.5s, and every injection 10-30 second, suction pump starts suction 10-30 second.The broken [that comes off is in time removed in gas pump and suction pump alternation.30-35 second is washed away in each position, and mobile thrombolysis catheter is carrying out aforesaid operations, after 3-6 minute, closes gas pump and suction pump through air scour.Open interface No. 3, get the 5ml syringe and be attached thereto.Get urokinase 250,000 U and be dissolved in the 25ml normal saline, in gained liquid gradation suction syringe, pressurized impulse injection in the thrombolysis catheter jet channel, namely be interrupted the pressurization administration, each vasopressing injection medicine 5ml, interval 5s, repetitive operation is also observed the patient respiratory pulse and is changed.Behind above-mentioned gas pulse and urokinase thrombolytic, carry out angiography and detect thrombolytic situation in the blood vessel.
Embodiment 6 jet animals except pin device are tested except bolt
1, the foundation of deep venous thrombosis animal model:
1) material: 10 of the male beasle dogs of healthy adult are provided by the PLA General Hospital Experimental Animal Center.Body weight 10～15kg, average 12.9kg; 2～4 years old age of dog, 2.7 years old age of average dog.The normal raising for 1 week before the experiment.Selecting the right lower extremity femoral vein is experimental side, and the left lower extremity femoral vein is control sides.
2) modeling method:
The initial intravenous injection 3% pentobarbital sodium 30mg/kg of dog, anaesthetize successfully after, dog lain on the back is fixed in operating-table, dog is amesiality.Left upper extremity is set up venous access, with 1～2/s persistent instillation normal saline.In the experimentation according to the Animal Anesthesia degree, in good time intravenous drip 3% pentobarbital sodium 1～2mL.
Behind the dog general anesthesia, expose femoral vein, the ligation femoral vein is near, far-end, unclamps ligature behind the 48h.Radiography confirms that thrombosis forms, and it is 100% that thrombotic model is made into power.
After above-mentioned thrombotic principle was the ligation femoral vein, regional flow was retarded by silt, anoxia, caused vascular endothelial cell damage, started intrinsic coagulation system.In addition, platelet also rests on the part because blood flow is obstructed with the local thrombin that forms, and causes thrombosis.
2, thrombosis is removed
The dog of above-mentioned 10 modeling successes is divided into two groups at random, and 5 usefulness of A group are of the present invention jetly remove bolt except pin devices, and 5 of B groups are removed bolt with many side openings of 5F thrombolysis catheter.
A group: determine the position of thrombosis in the vein by the phlebography technology, under the guiding of guiding wire, thrombolysis catheter delivered to the thrombolytic place.Thrombolysis catheter is inserted in the thrombosis, No. 1 interface is linked to each other with gas pump, No. 3 interface links to each other with suction pump, No. 2 and the sealing of No. 4 interfaces, and gas pump pulsed inflation in the jet channel, gas sprays from fumarole rapidly, washes away thrombosis.Broken [is alternately in time removed in gas pump and suction pump as previously mentioned.Each position was washed away 40 seconds, and mobile thrombolysis catheter carries out aforesaid operations again, after about 5 minutes, closed gas pump and suction pump through air scour.Open interface No. 3, get the 5ml syringe and be attached thereto.Get urokinase 250,000 U and be dissolved in the 25ml normal saline, in gained liquid gradation suction syringe, pressurized impulse injection in the thrombolysis catheter jet channel namely is interrupted the pressurization administration, each vasopressing injection medicine 5ml, 5s at interval.
B group: insert thrombolysis catheter from the femoral vein far-end, half side opening inserts in thrombosis, and second half stays the outside, and the urokinase of 500,000 U is dissolved in the 50ml normal saline, splashes into the speed of micro-injection pump 8ml/h.
3, experimental result
Perform the operation after 1 day and after 30 days, detect the unobstructed situation of vein that A group and B organize experimental dog respectively by angiography.The result shows behind the operative treatment 1 day, and A group and B group experimental dog vein patency rate are 100%, and it is that to organize experimental dog vein patency rate be 80% to 100%, B that the A that perform the operation after 30 days organizes experimental dog vein patency rate.
Above-mentioned experimental result shows of the present invention jet except pin device, under the situation of the urokinase that uses less amount, still can reach many gaging holes thrombolysis catheter on the present market except the bolt effect.So the present invention removes pin device except the bolt while, can reduce the risk of bringing patient's bleeding because of thrombolytic drug.
Claims (7)
- One kind jet except pin device, comprise: thrombolysis catheter, guiding wire, gas pump and suction pump, described thrombolysis catheter front end is distributed with fumarole and suction socket, and the thrombolysis catheter tail end links to each other with suction pump with gas pump, and described guiding wire is in the inside of thrombolysis catheter.
- 2. according to claim 1 jet except pin device, it is characterized in that, described thrombolysis catheter comprises jet channel and suction channel, jet channel and suction channel are coaxial, suction channel is in the outside of jet channel, also have guiding wire in jet channel, described jet channel communicates with gas pump, and described suction channel communicates with suction pump.
- 3. according to any described jet pin device that removes in claim 1 or 2, it is characterized in that, described fumarole is distributed in the 0.5～10cm scope of its front portion of thrombolysis catheter, the diameter of fumarole is 0.5～0.6mm, fumarole is distributed in the both sides of thrombolysis catheter, the quantity of every side fumarole is 5-8, and fumarole communicates with jet channel.
- 4. according to any described jet pin device that removes in claim 1 or 2, it is characterized in that, described suction socket is distributed in the scope of its anterior 0.5-10cm of thrombolysis catheter, the diameter of suction socket is 1.5～1.6mm, suction socket is distributed in the both sides of thrombolysis catheter, the quantity of every side suction socket is 5-8, and suction socket communicates with suction channel.
- 5. according to any described jet pin device that removes in claim 1 or 2, it is characterized in that described fumarole and suction socket are distributed in the both sides of thrombolysis catheter, the fumarole of every side and suction socket alternately occur.
- 6. according to any described jet pin device that removes in claim 1 or 2, it is characterized in that the pressure of described gas pump ejection gas is 100～200KPa, the gas that uses in the gas pump is carbon dioxide.
- 7. the described jet using method except pin device of claim 1:1) at first determines the position of thrombosis in the vein by the phlebography technology, under the guiding of guiding wire, thrombolysis catheter delivered to the thrombolytic place.2) thrombolysis catheter is inserted in the thrombosis, gas pump is the pulsed inflation in the jet channel, gas sprays from fumarole rapidly, wash away thrombosis, the pressure of gas pump ejection gas is 100～200KPa, sprays 1 time every 0.5s, and each injecting time is 0.5s, every spray 10-30 second, suction pump starts suction 10-30 second.The broken [that comes off is in time removed in gas pump and suction pump alternation, and 30-35 second is washed away in each position, and mobile thrombolysis catheter carries out aforesaid operations again, after about 3-6 minute, closes gas pump and suction pump through air scour.3) getting syringe links to each other with the thrombolysis catheter jet channel, getting thrombolytic drug is dissolved in the normal saline, in gained liquid gradation suction syringe, pressurized impulse injection in the thrombolysis catheter jet channel, namely be interrupted the pressurization administration, repetitive operation is also observed the variation of patient respiratory pulse, behind above-mentioned gas pulse and thrombolytic drug thrombolytic, carries out angiography and detects thrombolytic situation in the blood vessel.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104997550A (en) * | 2015-02-15 | 2015-10-28 | 首都医科大学宣武医院 | Blood vessel automatic thrombolysis system |
| CN105769294A (en) * | 2014-12-18 | 2016-07-20 | 罗继琴 | Blood guiding drainage type scalpel |
| CN107252339A (en) * | 2016-04-14 | 2017-10-17 | 丰凯医疗器械（上海）有限公司 | Intravascular Thrombus suction system |
| CN107397575A (en) * | 2017-08-25 | 2017-11-28 | 江西理工大学 | sheath for thrombus crushing system |
| CN112971925A (en) * | 2021-02-23 | 2021-06-18 | 祝恒 | Catheter suitable for dissolving and crushing thrombus of deep iliac femoral vein |
| CN113729855A (en) * | 2021-08-30 | 2021-12-03 | 浙江清华柔性电子技术研究院 | Insertion type combined ultrasonic thrombolysis device |
| CN114469257A (en) * | 2022-04-02 | 2022-05-13 | 北京华脉泰科医疗器械股份有限公司 | Thrombus removing device |
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| CN104997550A (en) * | 2015-02-15 | 2015-10-28 | 首都医科大学宣武医院 | Blood vessel automatic thrombolysis system |
| CN104997550B (en) * | 2015-02-15 | 2019-11-15 | 首都医科大学宣武医院 | A kind of automatic thrombus dissolving system of blood vessel |
| CN107252339A (en) * | 2016-04-14 | 2017-10-17 | 丰凯医疗器械（上海）有限公司 | Intravascular Thrombus suction system |
| CN107252339B (en) * | 2016-04-14 | 2019-11-08 | 丰凯医疗器械（上海）有限公司 | Intravascular Thrombus suction system |
| CN107397575A (en) * | 2017-08-25 | 2017-11-28 | 江西理工大学 | sheath for thrombus crushing system |
| CN107397575B (en) * | 2017-08-25 | 2021-04-09 | 江西理工大学 | Sheath tube for thrombus disruption system |
| CN112971925A (en) * | 2021-02-23 | 2021-06-18 | 祝恒 | Catheter suitable for dissolving and crushing thrombus of deep iliac femoral vein |
| CN113729855A (en) * | 2021-08-30 | 2021-12-03 | 浙江清华柔性电子技术研究院 | Insertion type combined ultrasonic thrombolysis device |
| CN113729855B (en) * | 2021-08-30 | 2023-11-14 | 浙江清华柔性电子技术研究院 | Interventional combined ultrasonic thrombolysis device |
| CN114469257A (en) * | 2022-04-02 | 2022-05-13 | 北京华脉泰科医疗器械股份有限公司 | Thrombus removing device |
| CN114469257B (en) * | 2022-04-02 | 2022-07-01 | 北京华脉泰科医疗器械股份有限公司 | Thrombus removing device |
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Effective date of registration: 20190731 Address after: Department of Interventional Radiology, General Hospital of Chinese People's Liberation Army, 28 Fuxing Road, Haidian District, Beijing, 100853 Patentee after: General Hospital of Chinese PLA Address before: Department of Interventional Radiology, Tumor Building, 28 Fuxing Road, Beijing, 100853 Patentee before: Liu Fengyong |