CN103118619B - 用于肾神经消融的多个柔性线丝上的rf电极 - Google Patents

用于肾神经消融的多个柔性线丝上的rf电极 Download PDF

Info

Publication number
CN103118619B
CN103118619B CN201180046875.XA CN201180046875A CN103118619B CN 103118619 B CN103118619 B CN 103118619B CN 201180046875 A CN201180046875 A CN 201180046875A CN 103118619 B CN103118619 B CN 103118619B
Authority
CN
China
Prior art keywords
elastic component
electrode
equipment
conduit
sheath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180046875.XA
Other languages
English (en)
Other versions
CN103118619A (zh
Inventor
P·A·哈弗科斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Boston Scientific Scimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Scimed Inc filed Critical Boston Scientific Scimed Inc
Publication of CN103118619A publication Critical patent/CN103118619A/zh
Application granted granted Critical
Publication of CN103118619B publication Critical patent/CN103118619B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A61B2018/00226—Balloons extending from a surface, i.e. Blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A61B2018/00232—Balloons having an irregular shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267—Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505—Urinary tract
    • A61B2018/00511—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1475—Electrodes retractable in or deployable from a housing

Abstract

一种导管包括具有远端的柔性轴，其长度被设置成用于在病人肾动脉内的展开。许多细长弹性构件被沿着轴的远端的纵向长度安装，并且能够在限定于纵向间隔的接合位置之间的区域处从轴径向地延伸。一个或多个电极在径向可延伸区域处被安装在弹性构件的每一个上。许多导体被电耦接到电极并沿着导管的轴延伸。细长弹性构件当被包围在外护套的腔内时是可收缩的，并且当导管和弹性构件轴向地延伸超过护套的远侧尖端时能够在限定于纵向间隔的接合位置之间的区域处从轴径向地向外延伸。RF能量被输送至电极以便消融血管周围肾神经。

Description

用于肾神经消融的多个柔性线丝上的RF电极
发明内容
本公开的实施例一般地涉及用于从脉管（vessel）内消融人体的目标组织的设备和方法。实施例涉及高频AC（例如，射频（RF））消融导管、系统以及方法，其采用多个柔性线丝上的电极以用于电极在目标脉管内的增强并置，特别是针对沿着脉管的内壁的不规则性而言。本公开的各种实施例涉及用于消融血管周围肾神经（诸如用于高血压治疗）的设备和方法。
根据各种实施例，一种用于输送消融治疗的设备包括护套，护套具有腔和相对于经皮进入位置足以进入病人体内的目标脉管的一段轴。导管包括具有近端、远端以及长度的柔性轴，轴的长度足以相对于经皮进入位置进入目标脉管。该轴的尺寸被设置成用于在护套的腔中移位并且可延伸超过护套的远侧尖端。
所述设备包括多个细长弹性构件，每个细长弹性构件沿着轴的远端的纵向长度安装。弹性构件在许多纵向间隔的位置接合轴，并且能够在限定于纵向间隔的接合位置之间的区域处从轴径向地延伸。一个或多个电极在径向可延伸区域处被安装在弹性构件的每一个上。许多导体被电耦接到电极并沿着导管的轴延伸。细长弹性构件当被包围在护套的腔内时是可皱缩的，并且当导管和弹性构件轴向地延伸超过护套的远侧尖端时能够在限定于纵向间隔的接合位置之间的区域处从轴径向地向外延伸。
根据某些实施例，一种设备包括护套，护套具有腔和足以相对于经皮进入位置进入病人的肾动脉的长度。导管包括具有近端、远端以及长度的柔性轴，轴的长度足以相对于经皮进入位置进入病人的肾动脉。轴的尺寸设置成用于在护套的腔内移位并且可延伸超过护套的远侧尖端。
所述设备包括许多细长弹性构件，每个细长弹性构件沿着轴的远端的纵向长度安装。弹性构件在许多纵向间隔的位置接合轴，并且能够在限定于纵向间隔的接合位置之间的区域处从轴径向地延伸。一个或多个电极在径向可延伸区域处被安装在弹性构件的每一个上。许多导体被电耦接到电极并沿着导管的轴延伸。细长弹性构件当被包围在护套的腔内时是可皱缩的，并且当导管和弹性构件轴向地延伸超过护套的远侧尖端时能够在限定于纵向间隔的接合位置之间的区域处从轴径向地向外延伸。
鉴于以下详细讨论和附图，可以理解这些以及其他特征。
附图说明
图1是右肾和包括从腹主动脉横向地分支的肾动脉的肾脉管系统的图示；
图2A和2B示出肾动脉的交感神经支配；
图3A示出肾动脉的壁的各种组织层；
图3B和3C示出肾神经的一部分；
图4A示出根据各种实施例的用于消融人体脉管的目标组织的设备；
图4B示出根据各种实施例的用于消融人体脉管的目标组织的设备；
图4C示出了当被包围在护套或目标脉管的腔内时的处于皱缩构造的消融治疗元件的细长弹性构件；
图5和6示出根据本公开的低断面实施例的支撑线丝段装置和缩回机构的导管轴的远端；
图7和8示出根据各种实施例的导管，其包括由线丝段装置支撑且具有组织移位特征的多个电极；
图9和10示出根据各种实施例的促进线丝段装置的可控扩张和缩回的布置；
图11示出根据各种实施例的具有绝缘套管或涂层的弹性构件；
图12-15示出消融治疗元件的各种实施例，其包括相对于彼此以结构协作构造安装的多个弹性构件；以及
图16示出根据各种实施例的代表性RF肾治疗设备。
具体实施方式
本公开的实施例涉及用于从脉管内消融目标组织的设备和方法。本公开的实施例涉及用于从肾动脉内消融血管周围肾神经以便治疗高血压的设备和方法。本公开的实施例包括支撑多个电极以便输送肾神经消融的线丝段结构。
在血管周围肾神经消融期间获得与动脉壁的良好接触是困难的。如果接触是可变的，则组织温度未受到很好的控制，并且可能不会在目标组织中实现消融温度，同时在诸如动脉壁各部分的其他区域中的温度可能偏离到足以引起不想要的动脉组织损伤。针对理想的解剖结构，可以更容易地实现良好的脉管壁贴合，但是尤其是在扭曲或患病肾动脉的情况下，可能存在非常差的接触而不能有效地且可预测地从消融设备向组织传输电流。可能期望多个离散区域处的受控消融以减少动脉损伤，而不要求多个重复定位和消融循环。存在对用于神经消融及其他治疗的改进的脉管壁接触和多点消融的持续需要。
本公开的实施例涉及用于血管周围肾神经的多点RF消融以用于高血压治疗的设备和方法。根据各种实施例，血管内导管设备在远端附近具有多个线丝段，其在低断面引入构造与大直径展开构造之间移动。一个或多个RF电极被安装在单独的线丝段上。线丝段可包括可扩张曲线、环路、网、篮或其他结构以将RF电极放置在单独的位置上。
当线丝段结构展开时，其弯曲以适应变化的脉管解剖结构。线丝段展开可以如在固定篮构造中被耦接，或者是独立的，使得每个线丝段扩张解剖结构要求的那么多。线丝段的展开将RF电极置于与脉管壁的良好接触。
可以使导管设备前进并在肾动脉中展开以消融肾神经。通过经由沿着导管的绝缘导体从外部能量源进行激励来激活某些RF电极或组合，提供多个离散的RF消融区域。展开可以利用自动扩张弹力、推/拉控制结构、外部保持和重新捕捉护套以及其他联动装置和结构。可以使用外护套在放置和收回期间在导管的远端处保护和约束线丝段。
根据各种实施例，血管内导管设备在远端附近具有多个线丝段，其在低断面引入构造与大直径展开构造之间移动。一个或多个RF电极被安装在单独的线丝段上。线丝段可包括可扩张曲线、环路、网、篮或其他结构以将RF电极放置在单独的位置上。当线丝段结构展开时，其弯曲以适应变化的脉管解剖结构。
在一个构造中，线丝段独立于其他线丝，使得每个线丝段扩张解剖结构要求的那么多。线丝段可以被绝缘并充当外部RF控制单元与电极之间的电导体。通过经由沿着导管的绝缘导体从外部能量源进行激励来激活某些RF电极或组合，提供多个离散的RF消融区域。展开可以利用自动扩张弹力、推/拉控制结构、外部保持和重新捕捉护套以及其他联动装置和结构。
线丝段的展开将RF电极置于与脉管壁的良好接触。可以使用外护套在放置和收回期间在导管的远端处保护和约束线丝段。可以使导管设备前进并在肾动脉中展开以消融肾神经。在将导管的远端定位于肾动脉内之后，可以使护套缩回以允许线丝段展开和扩张。
在其他实施例中，线丝段可以如在固定篮构造中被耦接，很像标测导管（mapping catheter）。可以同时地激励某些或所有电极，或者可以激励单独电极或电极的子集以消融血管周围神经的一个或多个区域。变化包括线丝段和电极的数目、周向位置和轴向位置。线丝段可以具有螺旋或其他弯曲。可以将线丝段构造为环路。
可以推动或拉动线丝的近端以帮助展开。可以将线丝段的远端附着于导管。可以提供腔段或滑动附着点以控制该线丝但允许展开移动。
可以用线丝段的推拉展开来将具有电极的多个线丝段结合到导管中。可以将电极成形为使内动脉壁的组织朝着外动脉壁移位，从而有效地缩短将电极和邻近于外动脉壁的神经支配目标组织分离的距离。根据各种实施例，电极包括组织移位尖端，其具有将内动脉壁强制地推入外动脉壁中（从而挤压中间的动脉壁组织）而不穿透内或外动脉壁的半径。在某些实施例中，可能期望允许电极尖端穿过内动脉壁，但是优选地不穿过外动脉壁。可以在前进和缩回期间使用外护套来覆盖线丝和电极。
可以在电极的位置处提供诸如热电偶的一个或多个温度传感器以测量电极的温度。在某些实施例中，温度传感器位于每个电极的位置处或附近，允许消融电极布置的单独电极位置处的精确温度测量。
本公开的各种实施例涉及用于治疗高血压的用于肾神经去除的设备和方法。高血压是血压升高的慢性医学疾病。持久性高血压是与多种负面医学疾病相关联的显著风险因素，包括心脏病发作、心力衰竭、动脉瘤以及中风。持久性高血压是慢性肾衰竭的主要原因。服务于肾的交感神经系统的亢进与高血压及其进展相关联。经由肾神经去除进行的肾中的神经去激活能够降低血压，并且可能是用于对常规药物没有反应的具有高血压的许多病人的可行治疗选择。
肾在许多人体过程中起作用，包括血液过滤、液体平衡的调节、血压控制、电解质平衡以及激素产生。肾的一个主要功能是从血液去除毒素、无机盐和水以形成尿。肾通过肾动脉接收心输出量的约20-25%，肾动脉从腹主动脉的左和右分支，在肾的凹面（即肾门）处进入每个肾。
血液通过肾动脉和输入小动脉流入肾，进入肾的过滤部分，即肾小球。肾小球由小球（即称为肾小囊的被充满体液的杯形囊围绕的毛细血管丛）组成。由于存在于毛细血管中的血压与肾小囊中的体液之间的压力梯度，血液中的溶解物通过小球的非常薄的毛细血管壁被过滤。由小动脉的收缩或扩张来控制压力梯度。在过滤发生之后，已过滤血液穿过输出小动脉和肾小管周围毛细血管，在小叶间静脉中汇合，并且最后通过肾静脉离开肾。
从血液过滤的颗粒和体液通过许多小管从肾小囊移动至集合管。尿在集合管中形成并随后通过输尿管和膀胱离开。小管被肾小管周围毛细血管（包含已过滤血液）围绕。随着滤液穿过小管并朝向集合管，营养素、水和电解液（诸如钠和氯化物）被再吸收到血液中。
肾是受肾丛神经支配的，肾丛主要源自于主动脉神经节。肾神经节由肾丛的神经在神经遵循肾动脉的路线并进入肾时形成。肾神经是自主神经系统的一部分，其包括交感和副交感组分。交感神经系统被称为提供人体“战斗或逃走”响应的系统，而副交感神经系统提供“休息与消化”响应。交感神经活动的刺激触发交感神经响应，其促使肾增加激素的产生，其增加血管收缩和体液潴留。此过程称为对于增加的肾交感神经活动的肾素－血管紧张素－醛甾酮－系统（RAAS）响应。
响应于血容量的减少，肾分泌肾素，这刺激了血管紧张素的产生。血管紧张素促使血管收缩，导致增加的血压，并且还刺激激素醛甾酮从肾上腺皮质的分泌。醛甾酮促使肾的小管增加钠和水的再吸收，这增加体内的液体量和血压。
充血性心力衰竭（CHF）是与肾功能有联系的疾病。当心脏不能遍及全身有效地泵送血液时发生CHF。当血流下降时，肾功能由于肾小球内的血液的不足灌注而下降。到肾的减少血流触发交感神经系统活动的增加（即，RAAS变得过于活动），这促使肾分泌增加体液潴留和血管收缩的激素。体液潴留和血管收缩又增加循环系统的外围阻力，对心脏施加甚至更大的负荷，这进一步减少血流。如果心脏和肾功能的退化继续，最后，身体垮掉，并且发生心力衰竭代偿失调的情况，常常导致病人的住院治疗。
图1是右肾10和包括从腹主动脉20横向地分支的肾动脉12的肾脉管系统的图示。在图1中，出于说明的简化目的，仅示出了右肾10，但是在本文中将对左肾和右肾两者以及相关联的肾脉管系统和神经系统结构进行参考，其在本公开的实施例的背景下全部被设想到。肾动脉12被有目的地示出为不成比例地大于右肾10和腹主动脉20，以便促进本公开的各种特征和实施例的讨论。
左肾和右肾被从左肾动脉和右肾动脉供应血液，左肾动脉和右肾动脉从腹主动脉20的各自的左横向表面和右横向表面分支。左肾动脉和右肾动脉中的每一个被指引跨越橫膈脚，从而与腹主动脉20几乎形成直角。左肾动脉和右肾动脉大体上从腹主动脉20延伸至接近于肾的肾门17的各自肾窦，并分支到分段动脉且随后分成肾10内的小叶间动脉。小叶间动脉向外辐射，穿透肾小囊并延伸通过肾锥体之间的肾柱。通常，肾接收总心输出量的约20%，其对于正常人而言代表每分钟通过肾的约1200 mL的血流。
肾的主要功能是通过控制尿的产生和浓度来保持用于人体的水和电介质平衡。在产生尿时，肾分泌诸如尿素和铵的废物。肾还控制葡萄糖和氨基酸的再吸收，并且在包括维他命D、肾素和促红细胞生成素的激素的产生中是重要的。
肾的重要辅助功能是控制人体的新陈代谢的动态平衡。控制止血功能包括调节电解液、酸碱平衡和血压。例如，肾负责通过例如调整在尿中损失的水容量并释放促红细胞生成素和肾素来调节血容量和压力。肾还通过控制在尿中损失的量和骨化三醇的合成来调节血浆离子浓度（例如纳、钾、氯离子、以及钙离子水平）。由肾控制的其他止血功能包括通过控制尿中的氢和重碳酸盐离子的损失来使血液pH稳定，通过防止有价值营养素的分泌来将其保留，以及帮助肝排毒。
在图1中还示出了右肾上腺11，一般称为右肾上腺。肾上腺11是停靠在肾10的顶部上的星形内分泌腺。肾上腺（左和右）的主要功能是通过皮质甾和儿茶酚胺（分别包括皮质醇和肾上腺素）的合成来调节人体的压力响应。围绕肾10、肾上腺11、肾脉管12以及相邻周围脂肪的是肾筋膜，例如Gerota筋膜（未示出），其是从腹膜外结缔组织衍生出的筋膜袋。
人体的自主神经系统控制血管、消化系统、心脏和腺中的平滑肌的不自主动作。自主神经系统被划分成交感神经系统和副交感神经系统。一般而言，副交感神经系统通过降低心率、降低血压和刺激消化来使身体准备好休息。交感神经系统通过增加心率、增加血压和增加新陈代谢来实行人体的战斗或逃跑响应。
在自主神经系统中，源自于中枢神经系统并延伸至各种神经节的纤维称为节前纤维，而从神经节延伸至效应器官的那些称为节后纤维。通过从肾上腺11释放肾上腺素和较小程度的降肾上腺素来实现交感神经系统的激活。这种肾上腺素的释放是由从节前交感神经释放的神经递质乙酰胆碱触发的。
肾和输尿管（未示出）是受肾神经14神经支配的。图1和2A-2B示出肾脉管系统的交感神经支配，主要是肾动脉12的神经支配。肾脉管系统的交感神经支配的主要功能包括肾血流量和血压的调节、肾素释放的刺激以及水和钠离子再吸收的直接刺激。
对肾脉管系统进行神经支配的大部分神经是从肠系膜上神经节26出现的交感节后纤维。肾神经14大体上轴向地沿着肾动脉12延伸，在肾门17处进入肾10，跟随肾10内的肾动脉12的分支，并延伸至单独的肾元。诸如肾神经节24、肠系膜上神经节26、左右主动脉神经节22和腹腔神经节28的其他肾神经节也对肾脉管系统进行神经支配。腹腔神经节28被较大胸内脏神经（较大TSN）连结。主动脉神经节26被较小胸内脏神经（较小TSN）连结并对肾丛的较大部分进行神经支配。
到肾10的交感信号是经由主要在脊柱段T10-T12和LI处发起的受神经支配的肾脉管系统传送的。副交感信号主要在脊柱段S2-S4处且从低位脑的延髓发起。交感神经往来穿过交感干神经节，在那里，某些可以形成突触，而其他的在主动脉神经节22（经由较小胸内脏神经，即较小TSN）和肾神经节24（经由最小胸内脏神经，即最小TSN）处形成突触。突触后交感信号然后沿着肾动脉12的神经14行进至肾10。突出前副交感信号行进至肾10附近的位置，然后它们在肾10上或附近形成突触。
特别地参考图2A，如大多数动脉和小动脉的情况一样，肾动脉12内衬有控制肾动脉腔13的直径的平滑肌34。平滑肌一般地是在大和小动脉和静脉的中间层以及各种器官内找到的非自主平滑肌。肾的血管小球例如包含称为系膜细胞的平滑肌状细胞。平滑肌在结构、功能、兴奋－收缩耦接、以及收缩机制方面根本上不同于骨骼肌和心肌。
可以刺激平滑肌细胞以通过自主神经系统收缩或松弛，但是还可以应来自相邻细胞的刺激并响应于激素和血液产生的电解液和药剂（例如，血管扩张剂或血管收缩剂）而起反应。例如，肾10的肾小球旁器的输入小动脉内的专用平滑肌细胞产生激活血管紧张素II系统的肾素。
肾神经14对肾动脉壁15的平滑肌34进行神经支配，并沿着肾动脉壁15以大体轴向或纵向方式纵长地延伸。平滑肌34周向地围绕肾动脉，并且沿着大体上横穿肾神经14的纵向取向的方向纵长地延伸，如图2B所示。
肾动脉12的平滑肌34处于自主神经系统的非自主控制下。交感活动的增加例如趋向于使平滑肌34收缩，这减小肾动脉腔13的直径并减少血液灌流。交感活动的减少趋向于促使平滑肌34松弛，导致脉管扩张和肾动脉腔直径和血液灌流的增加。相反，增加的副交感活动趋向于使平滑肌34松弛，而减少的副交感活动趋向于引起平滑肌收缩。
图3A示出了通过肾动脉的纵向横截面的一段，并且示出肾动脉12的壁15的各种组织层。肾动脉12的最内层是内皮30，其为内膜32的最内层并且由内弹性膜支撑。内皮30是接触流过脉管腔13的血液的单层细胞。内皮细胞通常是多边形的、椭圆形的或纺锭形的，并且具有非常可分辨的圆形或椭圆形核。内皮30的细胞与多血管功能有关，包括经由血管收缩和血管舒张的血压控制、血液凝固，并且充当腔13内的内含物与周围组织之间的阻挡层，诸如将内膜32与中间层34分离的内膜32的膜、以及外膜36。内膜32的膜或浸渍是高度弹性且一般具有纵向褶皱状图案的细微、透明、无色结构。
邻近于内膜32的是中间层33，其是肾动脉12的中间层。该中间层由平滑肌34和弹性组织构成。通过其色彩及通过其纤维的横向布置，可以很容易地识别中间层33。更特别地，中间层33主要由以薄板状方式或薄片布置并圆形地设置在动脉壁15周围的成束的平滑肌纤维34组成。肾动脉壁15的最外层是外膜36，其由结缔组织组成。外膜36包括在伤口愈合中起到重要作用的成纤维细胞38。
血管周围区域37被示出邻近于肾动脉壁15的外膜36并在其外围。肾神经14被示出接近于外膜36且穿过血管周围区域37的一部分。肾神经14被示出沿着肾动脉12的外壁15基本上纵向地延伸。肾神经14的主干一般存在于肾动脉12的外膜36中或上，常常穿过血管周围区域37，某些分支行进到中间层33中而使肾动脉平滑肌34无力。
可以将本公开的实施例实现为向受神经支配的肾脉管系统提供不同程度的去神经治疗。例如，本公开的实施例可以提供由使用本公开的治疗设备输送的去神经治疗是吸纳的肾神经脉冲传输中断的程度和相对持久性的控制。可以修整肾神经损伤的程序和相对持久性以实现期望的交感神经活动的减少（包括部分和完整块），并实现期望程度的持久性（包括暂时性或不可逆的损伤）。
返回图3B和3C，图3B和3C中所示的肾神经14的一部分包括神经纤维14b的束14a，每个包括轴突或树突，其在位于神经节中或脊髓上或脑中的细胞体或神经元上起源或终止。神经14的支撑组织结构14c包括神经内膜（围绕神经轴突纤维）、神经束膜（围绕纤维群以形成簇）以及神经外膜（将簇束缚于神经中），其用于分离和支撑神经纤维14b和束14a。特别地，特别地，也称为神经内膜管或小管的神经内膜是一层纤弱的结缔组织，其围绕簇内的神经纤维14b的髓鞘。
神经的主要组成部分包括作为包括核子的神经元的中心部分的体细胞、称为树突的细胞扩展部分以及作为载送神经信号的电缆状突出体的轴突。轴突终端包含突触，其是其中释放神经递质化学品以便与目标组织通信的专用结构。周围神经系统的许多神经元的轴突被覆盖在髓鞘质中，其由称为神经膜细胞的一种胶质细胞形成。髓鞘神经膜细胞缠绕在轴突周围，使得轴膜在称为郎飞结的规则间隔节点处相对未被覆盖。轴突的髓鞘化使得能够实现称为突变的电脉冲传播的特别快速模式。
在某些实施例中，可以将本公开的治疗设备实施为输送去神经治疗，其对肾神经纤维14b造成瞬时和可逆损伤。在其他实施例中，可以将本公开的治疗设备实施为输送去神经治疗，其对神神经纤维14b造成更严重损伤，其在治疗以及时的方式终止的情况下可以是可逆的。在优选实施例中，可以将本公开的治疗设备实施为输送去神经治疗，其对肾神经纤维14b造成严重且不可逆的损伤，导致肾交感神经活动的永久停止。例如，可以将治疗设备实施为输送去神经治疗，其使神经纤维形态中断至足以在物理上分离神经纤维14b的神经内膜管的程度，这能够防止再生和重新神经支配过程。
举例来说，并且根据在本领域中已知的Seddon分类，可以将本公开的治疗设备实施为通过按照机能性麻痹对肾神经纤维14b给予破坏来中断神经脉冲沿着肾神经纤维14b的传导。机能性麻痹描述了不存在神经纤维14b或其鞘的中断的神经损伤。在这种情况下，存在神经脉冲沿神经纤维的传导的中断，在没有实际再生的情况下在几小时至几个月内发生恢复，因为未发生沃勒变性。沃勒变性指的是与神经元的细胞核分离的轴突的一部分变性的过程。此过程也称为顺行性变性。机能性麻痹是最轻度的神经损伤，可以通过使用根据本公开的实施例的治疗设备来将其赋予到肾神经纤维14b。
可以将治疗设备实施为通过按照轴突断伤对肾神经纤维给予损伤来中断神经脉冲沿着肾神经纤维的传导。轴突断伤涉及神经纤维的轴突的相对连续性的损失及其髓鞘质的覆盖，但保留了神经纤维的结缔组织框架。在这种情况下，保留了神经纤维14b的包封支撑组织14c。由于失去了轴突连续性，所以发生沃勒变性。从轴突断伤的恢复仅通过轴突的再生而发生，该再生是要求约几个星期或几个月的时间的过程。在电学上，神经纤维14b显示出快速且完全的变性。只要神经内管是完好无损的，再生和重新神经支配就可以发生。
可以将治疗设备实施为通过按照神经断伤对肾神经纤维给予损伤来中断神经脉冲沿着肾神经纤维14b的传导。根据Seddon分类的神经断伤是方案中最严重的神经损伤。在此类损伤中，神经纤维14b和神经鞘两者被中断。虽然可以发生部分恢复，但完全恢复是不可能的。神经断伤涉及轴突和包封结缔组织14c的连续性的损失，在肾神经纤维14b的情况下，导致自主机能的完全丧失。如果神经纤维14b已被完全分开，则轴突再生促使在近侧残端中形成神经瘤。
通过参考如在本领域中已知的Sunderland系统，可以找到神经断伤神经损伤的更多层次的分类。Sunderland系统定义了五个程度的神经损伤，其中的前两个与Seddon分类的机能性麻痹和轴突断伤紧密地相对应。后三个Sunderland系统分类描述不同水平的神经断伤神经损伤。
Sunderland系统中的第一和第二程度的神经损伤分别类似于Seddon的机能性麻痹和轴突断伤。根据Sunderland系统，第三程度神经损伤涉及神经内膜的中断，神经外膜和神经束膜保持完好无损。根据束内纤维化，恢复可以在从很差至完全的范围内。第四程度神经损伤涉及所有神经和支撑元件的中断，神经外膜保持完好无损。神经通常扩大。第五程度的神经损伤涉及具有连续性损失的神经纤维14b的完全横断。
现在转到图4A，示出根据各种实施例的用于消融人体脉管的目标组织的设备。根据某些实施例，并且如图4A中所示，该设备包括护套119，护套119具有腔和相对于经皮进入位置足以进入病人的目标脉管（诸如病人的肾动脉）的长度。该设备还包括导管100，其包括具有近端、远端和长度的柔性轴104。轴104的长度相对于经皮进入位置足以进入目标脉管，诸如病人的肾动脉12。导管100的轴104的尺寸被设置成用于在护套119的腔内的移位，并且可延伸超过护套119的远侧尖端。
在导管的轴104的远端处提供了多个细长弹性构件131。在图4A中所示的代表性实施例中，在导管的轴104的远端处提供四个细长弹性构件131a-131d。细长弹性构件131a-131d中的每一个沿着轴104的远端的纵向长度安装，并且在两个或更多个纵向间隔的位置处接合轴104。细长弹性构件131a-131d被安装在轴104上，使得每个能够在限定于纵向间隔接合位置之间的区域处从轴104径向地延伸。细长弹性构件131a-131d由在弹性构件131a-131d中产生弹力的材料形成，该弹力在导管100和弹性构件131a-131d轴向地延伸超过轴104的远侧尖端时足以引起弹性构件131a-131d的自动扩张。例如，弹性构件131a-131d可以由柔性导电材料形成，其促进弹性构件131a-131d的弯曲以适应肾动脉解剖结构的变化。
一个或多个电极120在径向可延伸区域处被安装在每个弹性构件131a-131d上。在图4A中所示的代表性实施例中，示出了在轴104的纵向间隔接合位置之间的顶点位置处安装在四个弹性构件131a-131d中的每一个上的一个电极120-120d。导体装置电耦接到安装在每个弹性构件131a-131d上的一个或多个电极120并沿着轴104延伸至导管100的近端。
在某些实施例中，每个弹性构件131a-131d限定导体，其沿着轴104延伸并提供与导管100的近端处的电极120a-120d的电连接。可以用沿着轴104的长度延伸的区域上的绝缘套管或涂层来覆盖弹性构件131a-131。在其他实施例中，可以将轴104的单独腔的尺寸设置为接收弹性构件131a-131d中的一个，其可以包括弹性构件构造（其不包括绝缘套管或涂层）中的绝缘材料的内壁。在其他实施例中，可以将每个弹性构件131a-131d耦接到导管100的远端附近的各自电导体，并且该电导体可以沿着轴延伸并且可在导管100的近端处接近。
细长弹性构件131a-131d优选地由具有形状记忆的弹性导电合金构成。如在图4C中最好地看到的，细长弹性构件131a-131d当被包围在护套119的腔内或目标脉管（诸如病人肾动脉12）的腔内时是可皱缩的。当轴向地延伸超过护套119的远侧尖端时，弹性构件131a-131d在限定于纵向间隔的接合位置之间的区域处从轴104径向地向外扩张。安装在弹性构件131a-131d的顶点位置处或附近的电极120a-120d通过向外扩张的弹性构件131a-131d而向外移动并形成与目标脉管的内壁的被迫接合。在展开构造中，多个弹性构件131a-131d提供电极120a-120d在目标脉管内的增强并置，特别是针对沿着脉管内壁的不规则性而言。
根据各种实施例，弹性构件131a-131d被绕着导管的轴104的周界布置，使得电极120a-120d位于目标脉管（诸如肾动脉）的壁的互异位置处。例如，弹性构件131a-131d被绕着导管的轴104的周界布置，使得电极120a-120d形成大体上螺旋形状，以在导管100和弹性构件131a-1313d轴向地延伸超过护套119的远侧尖端时促进肾动脉壁中的螺旋损害的形成。
在某些实施例中，弹性构件131a-131d被沿着轴104的远端的纵向长度在结构上相互独立地安装。优选地选择弹性构件131a-131d的形状记忆，使得弹性构件131a-131d在处于其扩张展开构造时保持间隔开的关系。在此类构造中，不需要用绝缘套管或涂层来覆盖弹性构件131a-131d，不过如果期望的话，可以包括此类套管或涂层。根据利用紧密间隔的弹性构件131a-131d的其他实施例，可能期望用绝缘套管或涂层来覆盖（一个或多个）电极120a-120d近侧和远侧的弹性构件131a-131d。图11示出具有绝缘套管或涂层137的弹性构件131，绝缘套管或涂层137覆盖在由弹性构件131支撑的电极120近侧和远侧的弹性构件131的一些部分。
根据各种实施例，多个弹性构件131被沿着轴104的远端的纵向长度相对于彼此以结构协作构造安装。在图12-15中示出了此类实施例的说明性示例。图12例如示出了由许多弹性构件131形成且具有篮或网构造的线丝段装置127。篮或网的每个弹性构件131具有大体上弓形的形状，其相对的端部在公共的远侧和近侧周向安装区域处接合轴104。
图12中的每个弹性构件131被示为支撑多个电极120（例如，6个电极120）。在某些实施例中，将由单独弹性构件131支撑的电极120串联连接。在其他实施例中，经由单独导体来连接由单独弹性构件131支撑的电极120中的全部或至少某些。在此类实施例中，由单独弹性构件131支撑的所有或至少某些电极120是单独可控的，允许篮或网装置127的电极120的选择性激活和去激活。
可以将线丝段装置127的弹性构件131布置成形成可扩张曲线或环。在图13-15中示出了其他线丝段装置构造127的说明性示例。可设想这些及其他线丝段装置127，其可以在线丝段和电极的数目、周向位置和轴向位置方面改变。
可以同时地激励线丝段装置127的某些或所有电极120，或者可以激励单独电极120或电极120的子集以消融血管周围神经的一个或多个区域。例如，电极120可以是可单独激励的，以产生肾动脉的多个离散消融区域。线丝段装置127的一个或多个弹性构件131的电极120的选择性激活和去激活有利地提供具有多种形状（例如，螺旋的、周向的、斑点）和尺寸（例如，诸如通过在产生损害时增加或减少被激活电极120的数目）的损害的形成。本公开的这些及其他实施例促进在目标脉管中的具有期望形状和尺寸（例如，目标脉管壁的完整的一圈）的损害的形成，而不必在消融程序期间将导管轴104重新定位。
图4B示出根据各种实施例的用于消融人体脉管的目标组织的设备。在图4B中所示的实施例中，导管100包括安装在导管的轴104的远端处的多个细长弹性构件131，并且类似于图4A中所示的导管实施例。每个细长弹性构件131a-131d被沿着轴104的远端的纵向长度安装，在两个或更多纵向间隔位置处接合轴104，并且当被包围在护套119的腔内时是可皱缩的。当轴向地延伸超过护套119的远侧尖端时，弹性构件131a-131d从轴104径向地向外扩张，促使安装在弹性构件131a-131d的顶点位置处或附近的电极120a-120d向外移动并形成与目标脉管的内壁的被迫接合。
图4B中所示的实施例包括在导管100的远端处的线丝段装置处提供的温度传感器123。如图4B中所示，细长弹性构件131a-131d中的每一个支撑在细长弹性构件131a-131d的电极120a-120d处或附近提供的温度传感器123a-123d，诸如热电偶。每个温度传感器123a-123d被耦接到各自的传感器线丝，其沿着导管100的轴104的长度延伸并且可在导管100的近端处接近。
传感器线丝可以是以理发店旋转圆筒（barber pole）方式缠绕在弹性构件131周围的柔软的被绝缘的线丝。在其他构造中，传感器线丝可以平行于弹性构件131a-131d行进并且被结合到弹性构件131a-131d。在其他实施例中，可以用电绝缘套管或涂层来覆盖弹性构件131a-131d，在这种情况下，传感器线丝不需要具有电绝缘套管或涂层。
图5和6分别示出根据各种实施例的导管100，其包括以展开和缩回构造被线丝段装置支撑的多个电极。图5和6示出根据本公开的低断面实施例的导管轴104的远端，导管轴104支撑线丝段装置和缩回机构。在图5中所示的实施例中，导管100包括线丝段装置，其包括纵向地和周向地相互间隔的四个细长弹性构件131a-131d。四个细长弹性构件131a-131d中的每一个支撑电极120a-120d。弹性构件131a-131d和电极120a-120d被布置成使得可以消融目标脉管的至少一个整圈，而不必在消融程序期间将导管100重新定位。
导管轴104包括腔，一对控制线丝133a、133b延伸通过该腔。控制线丝133a、133b可以位于轴104的公共腔中或位于单独的腔中。控制线丝133a、133b的远端被耦接到弹性构件131a-131d的近端，其经由穿过轴壁的小孔或裂缝进入控制线丝腔。可以将密封装置在线丝段装置近侧定位于控制线丝腔中，以防止血液在密封装置近侧进入轴104。
在各种实施例中，控制线丝133a、133b被耦接到弹性构件131a-131d以由临床医生来提供弹性构件131a-131d的推拉展开和缩回。在某些构造中，两个最远侧弹性构件131a和131b的远端被耦接到控制线丝133a，并且两个最近侧弹性构件131c和131d的远端被耦接到控制线丝133b。当弹性构件131a和131b处于缩回构造（参见图6）时推控制线丝133a，促使弹性构件131a和131b从轴104向外移动成展开构造（参见图5）。当弹性构件131a和131b处于展开构造时拉控制线丝133a，促使弹性构件131a和131b向内移动至轴104的控制线丝腔中（如图6的缩回构造中所示）。可以通过以与上文关于控制线丝133a所述的相同方式来操纵控制线丝133b来使弹性构件131c和131d移动成展开和缩回构造。
在其他实施例中，弹性构件131a-131d中的每一个被耦接到单个控制线丝133。在此构造中，沿远侧方向推控制线丝133促使弹性构件131a-131d移动至展开构造。沿近侧方向拉控制线丝133促使弹性构件131a-131d移动至缩回构造。在其他实施例中，可以将每个弹性构件131a-131d耦接到单独的控制线丝131。在此构造中，可以通过推和拉被耦接到单独弹性构件131a-131d的各自控制线丝131来使单独弹性构件131a-131d移动至展开和缩回构造。可以使用护套（未示出）在导管100前进到目标脉管和从目标脉管缩回期间覆盖线丝段装置131a-131d和电极120a-120d。
图7和8示出根据各种实施例的导管100，其包括由线丝段装置支撑且具有组织移位特征的多个电极。出于清楚解释的目的，仅示出了支撑单个电极的一个线丝段装置。图7中所示的电极包括从电极主体120伸出的组织移位尖端125。组织移位尖端125的长度被选择为限制组织移位尖端125进入目标脉管壁的移位深度。例如，并且如图8中所示，电极120的组织移位尖端125所具有的长度和半径允许组织移位尖端125强制地使肾动脉壁12的壁的组织移位至规定深度但至少不刺穿肾动脉12的外壁。用于图8所示应用的组织移位电极120和尖端125通常具有不长于约2.5mm的长度。
将图7和8中所示的电极120构造成包括组织移位尖端125通过挤压内和外动脉壁之间的动脉组织来有效地减小电极120与目标组织（诸如血管周围肾神经）之间的距离。减小电极120与目标组织之间的距离有利地减少对相邻非目标组织的热损伤的程度，并且可以减小消融血管周围肾神经所需的电流密度。
图9和10示出根据各种实施例的促进线丝段装置的可控扩张和缩回的布置。在图9中所示的实施例中，支撑电极120的细长弹性构件131具有固定地位于轴104的外壁处的远端143。优选地经由进入孔口141将弹性构件131的远端1434结合或以其他方式附接到轴104的内壁安装位置。在图9中，以扩张展开构造示出了弹性构件131，其中，电极120被支撑在相对于轴104的外壁的横向高度h1处。在各种实施例中，横向高度h1可以相对于轴104的外壁在约1mm与约4.5mm之间的范围。
弹性构件131的近端被示为能够响应于施加到弹性构件131的近端或施加到被耦接到弹性构件131的近端的其他细长构件的指向近侧和远侧的力而移位。可以使弹性构件131的近端移位通过行进长度l1，其足以将弹性构件131相对于轴104的外壁的扩张和皱缩限制在横向高度尺寸h1内。当处于其缩回构造时，弹性构件131被抵靠着轴的外壁挤压，并且沿着轴104的外壁基本放平，将横向高度h1减小到比电极120和弹性构件131的组合厚度（例如，约0.2mm的组合厚度）多一小点。
当抵靠着轴的外壁挤压弹性构件131时，诸如当使输送护套在弹性构件131上前进时，迫使弹性构件131的近端向近侧进入轴104中的腔中或沿着轴104。弹性构件131的近端到其腔中的前进允许弹性构件131抵靠着轴104的外壁采取低断面。当去除输送护套时，自动扩张的弹性构件131扩张而采取其预成形形状，促使弹性构件131的近端向远侧移动一些而至少部分地从其腔出来。
在某些构造中，在弹性构件131的近端上施加指向远侧的力以实现弹性构件131的完全扩张。在其他构造中，形成弹性构件131的材料的弹力通过使弹性构件131上的张力放松来引起弹性构件131到其展开构造的自动扩张。在各种构造中，可以在弹性构件131的近端上施加一定程度的指向远侧的力以加强弹性构件131到其展开构造的自动扩张。
根据某些实施例，控制线丝133被附接到弹性构件131的远端，并且可由临床医生在导管100的近端处致动，例如以先前关于图5和6所述的方式。在其他实施例中，不使用控制线丝133，并且上文所讨论的缩回和扩张机制响应于在使用期间向弹性构件131施加挤压力和从弹性构件131去除挤压力而自动地操作。
在图10中所示的实施例中，示出了可滑动止动装置，该可滑动止动装置包括一对止动件151a、151b，其捕捉弹性构件131的至少一段。止动构件153被安装到弹性构件131。弹性构件131沿远侧方向的轴向移位的范围受到止动构件153与远侧止动件151a之间的接触的限制。弹性构件131沿近侧方向的轴向移位的范围受到止动构件153与近侧止动件151b之间的接触的限制。因此，弹性构件131的轴向移位的范围受到在一对止动件151a、151b之间所限定的行进距离l2的限制。此行进距离l2限制弹性构件131的横向高度h2在扩张和皱缩构造之间所能改变的程度。优选地将行进距离l2选择为允许弹性构件131在展开构造中的完全扩张以及弹性构件131的完全压缩以实现低断面缩回构造。
当沿着近侧方向拉弹性构件131（或被耦接到弹性构件131的控制线丝）使得止动构件153接触近侧止动件151b时，支撑电极的弹性构件131朝着轴104的外表面皱缩直至实现完全低断面缩回或皱缩构造。当释放弹性构件131上的张力和/或施加指向远侧的力时，止动构件153朝着远侧止动件151a前进，允许弹性构件131随着止动构件153朝着远侧止动件151a前进而自动扩张至其预成形展开形状。当止动构件153接触远侧止动件151a时，弹性构件131实现其展开构造。应注意的是，可以在轴104的腔内，在轴104的壁内或在至少部分地沿着轴104的外壁延伸的侧腔中实施图9和10所示的布置。
图16示出了根本公开的各种实施例的代表性RF肾治疗设备300。图16中所示的设备300包括外部电极激活电路320，其包括功率控制电路322和定时控制电路324。外部电极激活电路320（其包括RF发生器）被耦接到温度测量电路328，并且可以被耦接到任选的阻抗传感器326。导管100包括轴104，其包括被构造成根据需要或要求接收多种部件的腔装置105，所述多种部件诸如导体、药剂、致动器元件、闭塞物、传感器或其他部件。
外部电极激活电路320的RF发生器可以包括返回垫电极330，其被构造成在肾附近舒适地接合病人的后背或身体的其他部分。由RF发生器产生的射频能量被设置在导管轴104的腔中的导体装置110耦合到导管101的远端处的治疗元件101。
利用图16所示设备的肾去神经治疗通常通过使用由位于肾动脉12内的治疗元件101的线丝段装置支撑的电极120和位于病人后背上的返回垫电极330来执行，RF发生器以单极模式操作。在此实施方式中，电极120a-120d例如被构造成以单极构造操作。在其他实施方式中，由治疗元件101的线丝段装置支撑的电极120可以构造成以双极构造操作，在这种情况下，不需要返回电极垫330。
射频能量根据预定激活序列（例如顺续的或同时的）流过电极120，引起离子搅动并因此引起肾动脉的相邻组织中的摩擦。
一般地，当肾动脉组织温度上升至高于约113℉（50℃）时，蛋白质被永久性地破坏（包括肾神经纤维的那些）。如果加热至超过约65℃，则胶原变性且阻止萎缩。如果加热至超过约65℃且高达100℃，则细胞壁破裂且油与水分离。高于约100℃，组织脱水。
根据某些实施例，电极激活电路320被构造成根据预定能量输送协议且响应于从温度测量电路328接收到的信号来控制电极120的激活和去激活。电极激活电路320控制被输送到电极120的射频能量，从而将电流密度保持在足以将目标组织加热到至少约55℃的温度的水平。
在某些实施例中，温度传感器位于治疗元件101处并提供肾动脉组织温度的连续监测，并且RF发生器的功率被自动地调整，从而实现并保持目标温度。可以使用阻抗传感器装置326来测量和监测RF去神经治疗期间的电阻抗，并且可以基于阻抗测量或阻抗和温度测量的组合来调节RF发生器320的功率和定时。被消融区域的尺寸在很大程度上由治疗元件101的线丝段装置所支撑的电极120的尺寸、数目和形状、所施加的功率、施加能量的持续时间决定。
可以将标记带314放置在治疗元件101的一个或多个部分上以使得能够在手术期间实现可视化。导管101的其他部分，诸如轴104的一个或多个部分（例如，在铰链机构356处）可以包括标记带314。标记带314可以是例如铂或其他不透辐射金属的实心带或分裂带。不透辐射材料被理解成是这样的材料，其能够在医疗程序期间在荧光检查屏或其他成像技术上产生相对明亮的图像。此相对明亮的图像帮助用户确定导管100的特定部分，例如导管101的尖端、治疗元件101以及铰链356。根据某些实施例，导管100的辫子和/或电极可以是不透辐射的。
一般地，在用于控制高血压的血管周围肾神经消融术的背景下描述了本文公开的各种实施例。然而应理解的是本公开的实施例可在其他背景下应用，例如从身体的其他脉管（包括其他动脉、静脉和脉管系统，例如心脏和泌尿脉管系统和脉管）和身体的其他组织（包括各种器官）内执行消融。
应理解的是即使在前述说明中已经阐述了各种实施例的许多特性以及各种实施例的结构和功能的细节，但此详细说明仅仅是说明性的，并且可以在由用来表达所附权利要求的措辞的广泛一般意义所指示的完整程度上在细节方面进行修改，尤其是在由各种实施例说明的部分的结构和布置方面。

Claims (12)

1.一种用于输送消融治疗的设备，包括：
护套，所述护套具有腔和足以相对于经皮进入位置进入病人体内的目标脉管的一段轴；
导管，所述导管包括具有近端、远端和长度的柔性轴，所述柔性轴的长度足以相对于所述经皮进入位置进入所述目标脉管，所述柔性轴的尺寸被设置成用于在所述护套的腔内的移位并且能够延伸超过所述护套的远侧尖端；
多个细长弹性构件，每个沿着所述柔性轴的远端的纵向长度在结构上相互独立地安装，所述弹性构件在多个纵向间隔的位置处接合所述柔性轴并且能够在限定于纵向间隔的接合位置之间的区域处从所述柔性轴径向地延伸；
一个或多个消融电极，所述一个或多个消融电极在径向可延伸区域处被安装在所述弹性构件的每一个上；以及
多个导体，所述多个导体被电耦接到所述一个或多个消融电极并沿着所述导管的轴延伸；
所述细长弹性构件当被包围在所述护套的腔内时是可皱缩的，并且当所述导管和所述弹性构件轴向地延伸超过所述护套的远侧尖端时能够在限定于纵向间隔的接合位置之间的区域处从所述柔性轴径向地向外延伸，
其中，所述电极的每一个包括组织移位尖端，并且
其中每个所述细长弹性构件的近端相对于所述柔性轴能独立地移动。
2.根据权利要求1所述的设备，其中，所述弹性构件被绕着导管轴的周界布置以将电极定位在所述目标脉管的壁的互异位置处。
3.根据权利要求1所述的设备，其中，所述弹性构件被以篮或网构造布置。
4.根据权利要求1所述的设备，其中，所述弹性构件被布置成形成可扩张曲线或环。
5.根据权利要求1所述的设备，其中，所述弹性构件由柔性导电材料形成，其促进所述弹性构件的弯曲以适应目标脉管解剖结构的变化。
6.根据权利要求1所述的设备，其中，所述组织移位尖端被构造成相对于所述目标脉管的外壁将所述目标脉管的内壁的组织强制地移位至规定深度，但是至少不刺穿所述目标脉管的外壁。
7.根据权利要求1所述的设备，其中，所述电极能够单独地激励以产生所述目标脉管的多个离散的消融区域。
8.根据权利要求1所述的设备，其中，所述弹性构件由在所述弹性构件中产生弹力的材料形成，在所述导管和所述弹性构件轴向地延伸超过所述护套的远侧尖端时，所述弹力足以引起所述弹性构件的自动扩张。
9.根据权利要求1所述的设备，其中，所述弹性构件由柔性材料形成，其促进所述弹性构件响应于被施加到所述弹性构件的扩张和收缩控制力而扩张和收缩。
10.根据权利要求1所述的设备，其中，所述弹性构件在所述电极之间的一部分被电绝缘体覆盖。
11.根据权利要求1所述的设备，其中，所述电极绕着导管轴的周界分布，以在所述导管和所述弹性构件轴向地延伸超过所述护套的远侧尖端时促进所述目标脉管的壁中的螺旋损害的形成。
12.根据前述权利要求中的任一项所述的设备，其中，所述目标脉管包括肾动脉，并且所述一个或多个消融电极被构造成当所述导管和所述弹性构件轴向地延伸超过所述护套的远侧尖端时消融邻近于所述肾动脉的血管周围肾神经组织。
CN201180046875.XA 2010-07-30 2011-07-29 用于肾神经消融的多个柔性线丝上的rf电极 Expired - Fee Related CN103118619B (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US36945810P 2010-07-30 2010-07-30
US61/369,458 2010-07-30
US61/369458 2010-07-30
US41866710P 2010-12-01 2010-12-01
US61/418,667 2010-12-01
US61/418667 2010-12-01
US13/184,677 2011-07-18
US13/184,677 US9408661B2 (en) 2010-07-30 2011-07-18 RF electrodes on multiple flexible wires for renal nerve ablation
US13/184677 2011-07-18
PCT/US2011/045152 WO2012015722A1 (en) 2010-07-30 2011-07-29 Rf electrodes on multiple flexible wires for renal nerve ablation

Publications (2)

Publication Number Publication Date
CN103118619A CN103118619A (zh) 2013-05-22
CN103118619B true CN103118619B (zh) 2016-09-07

Family

ID=45527480

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180046875.XA Expired - Fee Related CN103118619B (zh) 2010-07-30 2011-07-29 用于肾神经消融的多个柔性线丝上的rf电极

Country Status (7)

Country Link
US (2) US9408661B2 (zh)
EP (1) EP2598069A1 (zh)
JP (1) JP5953302B2 (zh)
CN (1) CN103118619B (zh)
AU (1) AU2011282933A1 (zh)
CA (1) CA2806728A1 (zh)
WO (1) WO2012015722A1 (zh)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8774913B2 (en) * 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
EP3045136B1 (en) 2003-09-12 2021-02-24 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
EP1819304B1 (en) 2004-12-09 2023-01-25 Twelve, Inc. Aortic valve repair
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
EP2465574B1 (en) * 2006-06-28 2015-10-28 Ardian, Inc. Systems for thermally-induced renal neuromodulation
EP2992850A1 (en) 2006-10-18 2016-03-09 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
EP2076194B1 (en) 2006-10-18 2013-04-24 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
WO2008070189A2 (en) 2006-12-06 2008-06-12 The Cleveland Clinic Foundation Method and system for treating acute heart failure by neuromodulation
US8103327B2 (en) 2007-12-28 2012-01-24 Rhythmia Medical, Inc. Cardiac mapping catheter
CA2743992A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US20100168739A1 (en) * 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
CN103068330B (zh) 2010-04-09 2016-06-29 Vessix血管股份有限公司 用于治疗组织的功率发生和控制装置
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
EP3100696B1 (en) 2010-10-25 2023-01-11 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses having multi-electrode arrays for renal neuromodulation
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
CN103813745B (zh) 2011-07-20 2016-06-29 波士顿科学西美德公司 用以可视化、对准和消融神经的经皮装置及方法
CN103813829B (zh) 2011-07-22 2016-05-18 波士顿科学西美德公司 具有可定位于螺旋引导件中的神经调制元件的神经调制系统
WO2013055826A1 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
CN108095821B (zh) 2011-11-08 2021-05-25 波士顿科学西美德公司 孔部肾神经消融
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
EP2788078B1 (en) 2011-12-09 2020-09-02 Metavention, Inc. Therapeutic neuromodulation of the hepatic system
WO2013090848A1 (en) 2011-12-15 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for treating pulmonary hypertension
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP2793724B1 (en) 2011-12-23 2016-10-12 Vessix Vascular, Inc. Apparatuses for remodeling tissue of or adjacent to a body passage
CN104135958B (zh) 2011-12-28 2017-05-03 波士顿科学西美德公司 用有聚合物消融元件的新消融导管调变神经的装置和方法
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9439598B2 (en) 2012-04-12 2016-09-13 NeuroMedic, Inc. Mapping and ablation of nerves within arteries and tissues
CN107693114A (zh) 2012-04-24 2018-02-16 西比姆公司 用于颈动脉体摘除的血管内导管和方法
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
CA2872189A1 (en) 2012-05-11 2013-11-14 William W. CHANG Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods
WO2013181660A1 (en) 2012-06-01 2013-12-05 Cibiem, Inc. Methods and devices for cryogenic carotid body ablation
US9398930B2 (en) 2012-06-01 2016-07-26 Cibiem, Inc. Percutaneous methods and devices for carotid body ablation
KR101465159B1 (ko) * 2012-06-15 2014-11-25 주식회사 오에스와이메드 고주파 전달 전극 삽입장치
US9283033B2 (en) 2012-06-30 2016-03-15 Cibiem, Inc. Carotid body ablation via directed energy
US9955946B2 (en) 2014-03-12 2018-05-01 Cibiem, Inc. Carotid body ablation with a transvenous ultrasound imaging and ablation catheter
CN104540465A (zh) 2012-08-24 2015-04-22 波士顿科学西美德公司 带有含单独微孔隙区域的球囊的血管内导管
US8612022B1 (en) 2012-09-13 2013-12-17 Invatec S.P.A. Neuromodulation catheters and associated systems and methods
CN104780859B (zh) 2012-09-17 2017-07-25 波士顿科学西美德公司 用于肾神经调节的自定位电极系统及方法
US9333035B2 (en) 2012-09-19 2016-05-10 Denervx LLC Cooled microwave denervation
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
US10835305B2 (en) 2012-10-10 2020-11-17 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods
WO2014059351A1 (en) 2012-10-11 2014-04-17 Tva Medical, Inc. Devices and methods for fistula formation
CN102908191A (zh) 2012-11-13 2013-02-06 陈绍良 多极同步肺动脉射频消融导管
US9827036B2 (en) 2012-11-13 2017-11-28 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US11241267B2 (en) 2012-11-13 2022-02-08 Pulnovo Medical (Wuxi) Co., Ltd Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
USRE49433E1 (en) * 2013-02-05 2023-02-28 Handock Inc. Catheter for denervation
KR101465163B1 (ko) 2013-02-18 2014-11-25 주식회사 오에스와이메드 고주파 전달 전극 삽입장치
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
AU2014249776B2 (en) 2013-03-12 2017-04-20 Boston Scientific Scimed, Inc. Medical systems and methods for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9297845B2 (en) 2013-03-15 2016-03-29 Boston Scientific Scimed, Inc. Medical devices and methods for treatment of hypertension that utilize impedance compensation
JP6220044B2 (ja) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーションのための医療用デバイス
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US10022182B2 (en) 2013-06-21 2018-07-17 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
JP2016523147A (ja) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 同乗型電極支持体を備えた腎除神経バルーンカテーテル
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US10413357B2 (en) 2013-07-11 2019-09-17 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
EP3019105B1 (en) 2013-07-11 2017-09-13 Boston Scientific Scimed, Inc. Devices for nerve modulation
CN105682594B (zh) 2013-07-19 2018-06-22 波士顿科学国际有限公司 螺旋双极电极肾脏去神经支配气囊
EP3024406B1 (en) 2013-07-22 2019-06-19 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3024405A1 (en) 2013-07-22 2016-06-01 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
US20160199127A1 (en) * 2013-08-14 2016-07-14 La Vita Technologies Ltd. Methods and apparatuses for treating auto-immune diseases by ablative neuromodulation
WO2015027096A1 (en) 2013-08-22 2015-02-26 Boston Scientific Scimed, Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
US9913684B2 (en) 2013-08-23 2018-03-13 Oscor Inc. Steerable ablation catheter for renal denervation
US9907570B2 (en) 2013-08-23 2018-03-06 Oscor Inc. Steerable medical devices
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
US20150073515A1 (en) 2013-09-09 2015-03-12 Medtronic Ardian Luxembourg S.a.r.I. Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods
EP3043733A1 (en) 2013-09-13 2016-07-20 Boston Scientific Scimed, Inc. Ablation balloon with vapor deposited cover layer
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9687166B2 (en) 2013-10-14 2017-06-27 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
US9962223B2 (en) 2013-10-15 2018-05-08 Boston Scientific Scimed, Inc. Medical device balloon
EP3057521B1 (en) 2013-10-18 2020-03-25 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires
US10390881B2 (en) 2013-10-25 2019-08-27 Denervx LLC Cooled microwave denervation catheter with insertion feature
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
EP3091922B1 (en) 2014-01-06 2018-10-17 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
US20150209107A1 (en) 2014-01-24 2015-07-30 Denervx LLC Cooled microwave denervation catheter configuration
EP3424453A1 (en) 2014-02-04 2019-01-09 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
US10463424B2 (en) * 2014-03-11 2019-11-05 Medtronic Ardian Luxembourg S.A.R.L. Catheters with independent radial-expansion members and associated devices, systems, and methods
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
WO2015164280A1 (en) 2014-04-24 2015-10-29 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters having braided shafts and associated systems and methods
US10478249B2 (en) 2014-05-07 2019-11-19 Pythagoras Medical Ltd. Controlled tissue ablation techniques
WO2015179634A2 (en) 2014-05-22 2015-11-26 CARDIONOMIC, Inc. Catheter and catheter system for electrical neuromodulation
WO2015187430A2 (en) * 2014-06-04 2015-12-10 Boston Scientific Scimed, Inc. Electrode assembly
EP3194017A1 (en) 2014-09-08 2017-07-26 Cardionomic, Inc. Methods for electrical neuromodulation of the heart
AU2015315658B2 (en) * 2014-09-08 2019-05-23 CARDIONOMIC, Inc. Catheter and electrode systems for electrical neuromodulation
EP3242717B1 (en) 2015-01-05 2019-06-12 Cardionomic, Inc. Cardiac modulation facilitation systems
US10376308B2 (en) 2015-02-05 2019-08-13 Axon Therapies, Inc. Devices and methods for treatment of heart failure by splanchnic nerve ablation
US10342611B2 (en) 2015-04-29 2019-07-09 Innoblative Designs, Inc. Cavitary tissue ablation
US10383685B2 (en) 2015-05-07 2019-08-20 Pythagoras Medical Ltd. Techniques for use with nerve tissue
US10799287B2 (en) 2015-07-07 2020-10-13 Boston Scientific Scimed, Inc. Medical device having extenable members
EP3367945B1 (en) * 2015-10-29 2020-02-26 Innoblative Designs, Inc. Screen sphere tissue ablation devices
WO2017105351A1 (en) * 2015-12-15 2017-06-22 Agency For Science, Technology And Research Method and deployable multi-spine apparatus for catheter-based renal denervation
US11026743B2 (en) 2016-01-15 2021-06-08 Tva Medical, Inc. Devices and methods for forming a fistula
US10874422B2 (en) 2016-01-15 2020-12-29 Tva Medical, Inc. Systems and methods for increasing blood flow
US20170215947A1 (en) 2016-02-02 2017-08-03 Innoblative Designs, Inc. Cavitary tissue ablation system
US10869714B2 (en) 2016-03-01 2020-12-22 Innoblative Designs, Inc. Resecting and coagulating tissue
EP3426338A4 (en) 2016-03-09 2019-10-30 Cardionomic, Inc. SYSTEMS AND METHODS FOR NEUROSTIMULATION OF CARDIAC CONTRACTILITY
WO2017199240A2 (en) 2016-05-18 2017-11-23 Pythagoras Medical Ltd. Helical catheter
CN109475734B (zh) * 2016-05-24 2024-02-13 洛桑联邦理工学院 腔内神经调制设备及其使用方法
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
CA3031766A1 (en) * 2016-07-29 2018-02-01 Howard Levin Devices, systems, and methods for treatment of heart failure by splanchnic nerve ablation
DE102016116871A1 (de) * 2016-09-08 2018-03-08 Phenox Gmbh Vorrichtung und Verfahren zur Vorbeugung und Behandlung eines Vasospasmus
US10070921B2 (en) 2016-10-17 2018-09-11 Innoblative Designs, Inc. Treatment devices and methods
JP6875757B2 (ja) 2016-11-08 2021-05-26 イノブレイティブ デザインズ， インコーポレイテッド 電気手術の組織および脈管シールデバイス
US11786297B2 (en) 2017-07-26 2023-10-17 Innoblative Designs, Inc. Minimally invasive articulating assembly having ablation capabilities
CN109563818B (zh) * 2017-07-27 2022-05-06 松下知识产权经营株式会社 驱动致动器的方法、致动器及制造致动器的方法
EP3664703A4 (en) 2017-09-13 2021-05-12 Cardionomic, Inc. NEUROSTIMULATION SYSTEMS AND METHODS FOR INFLUENCING HEART CONTRACTILITY
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
WO2019118976A1 (en) 2017-12-17 2019-06-20 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
JP7334167B2 (ja) 2018-01-26 2023-08-28 アクソン セラピーズ，インク． 内臓神経の血管内アブレーションの為の方法及びデバイス
CA3107959A1 (en) 2018-08-13 2020-02-20 CARDIONOMIC, Inc. Systems and methods for affecting cardiac contractility and/or relaxation
CA3137307A1 (en) 2019-05-06 2020-11-12 CARDIONOMIC, Inc. Systems and methods for denoising physiological signals during electrical neuromodulation
EP3917426B1 (en) 2019-06-20 2023-09-06 Axon Therapies, Inc. Devices for endovascular ablation of a splanchnic nerve
WO2021059273A2 (en) 2019-09-26 2021-04-01 Universitat Zurich Left atrial appendage occlusion devices
ES2960299T3 (es) 2020-01-17 2024-03-04 Axon Therapies Inc Dispositivos para la ablación endovascular de un nervio esplácnico
EP4108197A1 (en) 2021-06-24 2022-12-28 Gradient Denervation Technologies Systems for treating tissue

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772590A (en) * 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US6165172A (en) * 1997-09-11 2000-12-26 Vnus Medical Technologies, Inc. Expandable vein ligator catheter and method of use
CN101511292A (zh) * 2005-03-28 2009-08-19 明诺医学有限公司 用于选择性地治疗动脉粥样硬化和其他目标组织的内腔电组织表征和调谐射频能量

Family Cites Families (1197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US164184A (en) 1875-06-08 Improvement in vesicular electrodes
US1167014A (en) 1915-06-25 1916-01-04 William R O'brien Veterinary surgical instrument.
US2505358A (en) 1949-04-20 1950-04-25 Sklar Mfg Co Inc J Double-cutting biopsy bistoury
US2701559A (en) 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US3108593A (en) 1961-03-13 1963-10-29 Jacob A Glassman Surgical extractor
US3108594A (en) 1962-08-14 1963-10-29 Jacob A Glassman Surgical extractor and method of use
US3540431A (en) 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US6014590A (en) 1974-03-04 2000-01-11 Ep Technologies, Inc. Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions
US3952747A (en) 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4046150A (en) 1975-07-17 1977-09-06 American Hospital Supply Corporation Medical instrument for locating and removing occlusive objects
US4290427A (en) 1979-11-26 1981-09-22 Thomas J. Fogarty Endarterectomy apparatus
US4402686A (en) 1981-07-09 1983-09-06 Medel Gonzalo A Pinched nerve instrument
US4483341A (en) 1982-12-09 1984-11-20 Atlantic Richfield Company Therapeutic hypothermia instrument
US4784132A (en) 1983-03-25 1988-11-15 Fox Kenneth R Method of and apparatus for laser treatment of body lumens
EP0152766A1 (en) 1984-01-24 1985-08-28 Shiley Incorporated Reduction of an arteriosclerotic lesion by selective absorption of electromagnetic energy in a component thereof
US4574804A (en) 1984-02-27 1986-03-11 Board Of Regents, The University Of Texas System Optic nerve clamp
US4682596A (en) 1984-05-22 1987-07-28 Cordis Corporation Electrosurgical catheter and method for vascular applications
US4587975A (en) 1984-07-02 1986-05-13 Cardiac Pacemakers, Inc. Dimension sensitive angioplasty catheter
US5162217A (en) 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US5143836A (en) 1984-08-27 1992-09-01 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US6030611A (en) 1984-08-27 2000-02-29 Bio-Technology General Corp. Therapeutic SOD compositions and uses thereof
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4799479A (en) 1984-10-24 1989-01-24 The Beth Israel Hospital Association Method and apparatus for angioplasty
US5318024A (en) 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
US5693043A (en) 1985-03-22 1997-12-02 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US5034010A (en) 1985-03-22 1991-07-23 Massachusetts Institute Of Technology Optical shield for a laser catheter
US20020045811A1 (en) 1985-03-22 2002-04-18 Carter Kittrell Laser ablation process and apparatus
US4862886A (en) 1985-05-08 1989-09-05 Summit Technology Inc. Laser angioplasty
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
GB8622797D0 (en) 1986-09-22 1986-10-29 Allied Colloids Ltd Polymeric particles
US4784162A (en) 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
US5231995A (en) 1986-11-14 1993-08-03 Desai Jawahar M Method for catheter mapping and ablation
US4785806A (en) 1987-01-08 1988-11-22 Yale University Laser ablation process and apparatus
US4790310A (en) 1987-02-04 1988-12-13 Robert Ginsburg Laser catheter having wide angle sweep
US4765331A (en) 1987-02-10 1988-08-23 Circon Corporation Electrosurgical device with treatment arc of less than 360 degrees
US4823791A (en) 1987-05-08 1989-04-25 Circon Acmi Division Of Circon Corporation Electrosurgical probe apparatus
US4770653A (en) 1987-06-25 1988-09-13 Medilase, Inc. Laser angioplasty
US4938766A (en) 1987-08-28 1990-07-03 Jarvik Robert K Prosthetic compliance devices
US5154705A (en) 1987-09-30 1992-10-13 Lake Region Manufacturing Co., Inc. Hollow lumen cable apparatus
US4788975B1 (en) 1987-11-05 1999-03-02 Trimedyne Inc Control system and method for improved laser angioplasty
US4887605A (en) 1988-02-18 1989-12-19 Angelsen Bjorn A J Laser catheter delivery system for controlled atheroma ablation combining laser angioplasty and intra-arterial ultrasonic imagining
US5372138A (en) 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
US5178620A (en) 1988-06-10 1993-01-12 Advanced Angioplasty Products, Inc. Thermal dilatation catheter and method
US4830003A (en) 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
DE68922497T2 (de) 1988-08-24 1995-09-14 Marvin J Slepian Endoluminale dichtung mit bisdegradierbaren polymeren.
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US6066130A (en) 1988-10-24 2000-05-23 The General Hospital Corporation Delivering laser energy
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US5129396A (en) 1988-11-10 1992-07-14 Arye Rosen Microwave aided balloon angioplasty with lumen measurement
ATE133545T1 (de) 1988-12-21 1996-02-15 Massachusetts Inst Technology Verfahren für laserinduzierte fluoreszenz von gewebe
US5697369A (en) 1988-12-22 1997-12-16 Biofield Corp. Method and apparatus for disease, injury and bodily condition screening or sensing
WO1990007303A1 (en) 1989-01-06 1990-07-12 Angioplasty Systems, Inc. Electrosurgical catheter for resolving atherosclerotic plaque
US5749914A (en) 1989-01-06 1998-05-12 Advanced Coronary Intervention Catheter for obstructed stent
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
US5052402A (en) 1989-01-31 1991-10-01 C.R. Bard, Inc. Disposable biopsy forceps
US5453091A (en) 1989-03-17 1995-09-26 Merit Medical Systems, Inc. RF transmission module for wirelessly transmitting balloon catheter data in a syringe inflation system
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5098431A (en) 1989-04-13 1992-03-24 Everest Medical Corporation RF ablation catheter
US5071424A (en) 1989-08-18 1991-12-10 Evi Corporation Catheter atherotome
US5156610A (en) 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
US5662701A (en) 1989-08-18 1997-09-02 Endovascular Instruments, Inc. Anti-stenotic method and product for occluded and partially occluded arteries
US5211651A (en) 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
JP3036835B2 (ja) 1989-08-18 2000-04-24 イーブイアイ コーポレイション カテーテルアテロトーム
US5282484A (en) 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
DE69029141T2 (de) 1989-09-08 1997-04-10 Boston Scient Corp Angioplastie mit niedrigem physiologischen stress
US5109859A (en) 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
US5344395A (en) 1989-11-13 1994-09-06 Scimed Life Systems, Inc. Apparatus for intravascular cavitation or delivery of low frequency mechanical energy
US5178625A (en) 1989-12-07 1993-01-12 Evi Corporation Catheter atherotome
US5074871A (en) 1989-12-07 1991-12-24 Evi Corporation Catheter atherotome
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5158564A (en) 1990-02-14 1992-10-27 Angiomed Ag Atherectomy apparatus
US5084006A (en) 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5098429A (en) 1990-04-17 1992-03-24 Mmtc, Inc. Angioplastic technique employing an inductively-heated ferrite material
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
ATE123658T1 (de) 1990-06-15 1995-06-15 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5053033A (en) 1990-10-10 1991-10-01 Boston Advanced Technologies, Inc. Inhibition of restenosis by ultraviolet radiation
US5304171A (en) 1990-10-18 1994-04-19 Gregory Kenton W Catheter devices and methods for delivering
US5139496A (en) 1990-12-20 1992-08-18 Hed Aharon Z Ultrasonic freeze ablation catheters and probes
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5997497A (en) 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US5368557A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having multiple ultrasound transmission members
US5312328A (en) 1991-01-11 1994-05-17 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5304115A (en) 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5447509A (en) 1991-01-11 1995-09-05 Baxter International Inc. Ultrasound catheter system having modulated output with feedback control
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5368558A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5916192A (en) 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use
US5542917A (en) 1991-01-11 1996-08-06 Baxter International, Inc. Ultrasound delivery catheters incorporating improved distal tip construction
US5405318A (en) 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5380274A (en) 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5957882A (en) 1991-01-11 1999-09-28 Advanced Cardiovascular Systems, Inc. Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels
US5267954A (en) 1991-01-11 1993-12-07 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5234407A (en) 1991-03-06 1993-08-10 Baxter International Inc. Method and device for exchanging cardiovascular guide catheter while a previously inserted angioplasty guide wire remains in place
US5454788A (en) 1991-04-24 1995-10-03 Baxter International Inc. Exchangeable integrated-wire balloon catheter
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US6309379B1 (en) 1991-05-23 2001-10-30 Lloyd K. Willard Sheath for selective delivery of multiple intravascular devices and methods of use thereof
US5270654A (en) 1991-07-05 1993-12-14 Feinberg David A Ultra-fast multi-section MRI using gradient and spin echo (grase) imaging
US5383917A (en) 1991-07-05 1995-01-24 Jawahar M. Desai Device and method for multi-phase radio-frequency ablation
JPH0596012A (ja) 1991-10-07 1993-04-20 Olympus Optical Co Ltd 温熱治療装置
US5697909A (en) 1992-01-07 1997-12-16 Arthrocare Corporation Methods and apparatus for surgical cutting
EP0611293B1 (en) 1991-11-04 1998-03-25 Baxter International Inc. Ultrasonic ablation device adapted for guidewire passage
US5906614A (en) 1991-11-08 1999-05-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using predicted temperature for monitoring and control
US5383874A (en) 1991-11-08 1995-01-24 Ep Technologies, Inc. Systems for identifying catheters and monitoring their use
ATE241938T1 (de) 1991-11-08 2003-06-15 Boston Scient Ltd Ablationselektrode mit isoliertem temperaturmesselement
ATE144124T1 (de) 1991-12-20 1996-11-15 Technomed Medical Systems Schallwellen aussendende,thermische effekte und kavitationseffekte erzeugende vorrichtung fur die ultraschalltherapie
US5498261A (en) 1991-12-20 1996-03-12 Advanced Cardiovascular Systems, Inc. Thermal angioplasty system
US5301683A (en) 1991-12-23 1994-04-12 Durkan John A Diagnosing carpal tunnel syndrome
US5522873A (en) 1991-12-26 1996-06-04 Webster Laboratories, Inc. Catheter having electrode with annular recess and method of using same
US5681282A (en) 1992-01-07 1997-10-28 Arthrocare Corporation Methods and apparatus for ablation of luminal tissues
US6179824B1 (en) 1993-05-10 2001-01-30 Arthrocare Corporation System and methods for electrosurgical restenosis of body lumens
US5419767A (en) 1992-01-07 1995-05-30 Thapliyal And Eggers Partners Methods and apparatus for advancing catheters through severely occluded body lumens
US5242441A (en) 1992-02-24 1993-09-07 Boaz Avitall Deflectable catheter with rotatable tip electrode
US5263493A (en) 1992-02-24 1993-11-23 Boaz Avitall Deflectable loop electrode array mapping and ablation catheter for cardiac chambers
US5330518A (en) 1992-03-06 1994-07-19 Urologix, Inc. Method for treating interstitial tissue associated with microwave thermal therapy
US5306250A (en) 1992-04-02 1994-04-26 Indiana University Foundation Method and apparatus for intravascular drug delivery
US5573533A (en) 1992-04-10 1996-11-12 Medtronic Cardiorhythm Method and system for radiofrequency ablation of cardiac tissue
US5540681A (en) 1992-04-10 1996-07-30 Medtronic Cardiorhythm Method and system for radiofrequency ablation of tissue
US5314466A (en) 1992-04-13 1994-05-24 Ep Technologies, Inc. Articulated unidirectional microwave antenna systems for cardiac ablation
US5300068A (en) 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
JPH07506991A (ja) 1992-04-23 1995-08-03 シメッド　ライフ　システムズ　インコーポレイテッド 血管穿刺を密封するための装置及び方法
US5810810A (en) 1992-04-23 1998-09-22 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US6063085A (en) 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
USRE40863E1 (en) 1992-04-23 2009-07-21 Boston Scientific Scimed, Inc. Apparatus and method for sealing vascular punctures
US5443470A (en) 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5277201A (en) 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5295484A (en) 1992-05-19 1994-03-22 Arizona Board Of Regents For And On Behalf Of The University Of Arizona Apparatus and method for intra-cardiac ablation of arrhythmias
US5255679A (en) 1992-06-02 1993-10-26 Cardiac Pathways Corporation Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method
US5478351A (en) 1992-06-24 1995-12-26 Microsurge, Inc. Endoscopic surgical tool with handle and detachable tool assembly
DE69328096T2 (de) 1992-06-26 2000-09-14 Schneider Usa Inc Katheter mit ausdehnbarer maschendrahtspitze
US5382228A (en) 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5365172A (en) 1992-08-07 1994-11-15 Brigham And Women's Hospital Methods and apparatus for MRI
US5297564A (en) 1992-08-27 1994-03-29 Love Jack W Catheter technique for creation of an aortico-pulmonary shunt
US5401272A (en) 1992-09-25 1995-03-28 Envision Surgical Systems, Inc. Multimodality probe with extendable bipolar electrodes
US5333614A (en) 1992-09-28 1994-08-02 Feiring Andrew J Measurement of absolute vascular flow
US5471982A (en) 1992-09-29 1995-12-05 Ep Technologies, Inc. Cardiac mapping and ablation systems
US6086581A (en) 1992-09-29 2000-07-11 Ep Technologies, Inc. Large surface cardiac ablation catheter that assumes a low profile during introduction into the heart
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
CA2107741C (en) 1992-10-07 2000-06-27 Peter T. Keith Ablation devices and methods of use
US6398782B1 (en) 1992-10-13 2002-06-04 Edwards Lifesciences Corporation Bipolar vascular sealing apparatus and methods
US5432876C1 (en) 1992-10-19 2002-05-21 Minnesota Mining & Mfg Illumination devices and optical fibres for use therein
US5634901A (en) 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
US5571122A (en) 1992-11-09 1996-11-05 Endovascular Instruments, Inc. Unitary removal of plaque
US5643297A (en) 1992-11-09 1997-07-01 Endovascular Instruments, Inc. Intra-artery obstruction clearing apparatus and methods
US5676693A (en) 1992-11-13 1997-10-14 Scimed Life Systems, Inc. Electrophysiology device
WO1994010922A1 (en) 1992-11-13 1994-05-26 Ep Technologies, Inc. Cardial ablation systems using temperature monitoring
US6068653A (en) 1992-11-13 2000-05-30 Scimed Life Systems, Inc. Electrophysiology catheter device
US6923805B1 (en) 1992-11-13 2005-08-02 Scimed Life Systems, Inc. Electrophysiology energy treatment devices and methods of use
DE4338758C2 (de) 1992-11-13 2001-08-09 Scimed Life Systems Inc Katheteranordnung
US5545161A (en) 1992-12-01 1996-08-13 Cardiac Pathways Corporation Catheter for RF ablation having cooled electrode with electrically insulated sleeve
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5706809A (en) 1993-01-29 1998-01-13 Cardima, Inc. Method and system for using multiple intravascular sensing devices to detect electrical activity
CA2114988A1 (en) 1993-02-05 1994-08-06 Matthew O'boyle Ultrasonic angioplasty balloon catheter
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US6161543A (en) 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5403311A (en) 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US6915806B2 (en) 1993-05-10 2005-07-12 Arthrocare Corporation Method for harvesting graft vessel
US5693082A (en) 1993-05-14 1997-12-02 Fidus Medical Technology Corporation Tunable microwave ablation catheter system and method
US5405346A (en) 1993-05-14 1995-04-11 Fidus Medical Technology Corporation Tunable microwave ablation catheter
US5364392A (en) 1993-05-14 1994-11-15 Fidus Medical Technology Corporation Microwave ablation catheter system with impedance matching tuner and method
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
US5630837A (en) 1993-07-01 1997-05-20 Boston Scientific Corporation Acoustic ablation
CA2165829A1 (en) 1993-07-01 1995-01-19 John E. Abele Imaging, electrical potential sensing, and ablation catheters
US5584831A (en) 1993-07-09 1996-12-17 September 28, Inc. Spinal fixation device and method
US5409000A (en) 1993-09-14 1995-04-25 Cardiac Pathways Corporation Endocardial mapping and ablation system utilizing separately controlled steerable ablation catheter with ultrasonic imaging capabilities and method
US5843124A (en) 1993-09-28 1998-12-01 Hemodynamics, Inc. Surface opening adhesive sealer
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5417672A (en) 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5496312A (en) 1993-10-07 1996-03-05 Valleylab Inc. Impedance and temperature generator control
EP0754075B1 (en) 1993-10-14 2006-03-15 Boston Scientific Limited Electrode elements for forming lesion patterns
US5991650A (en) 1993-10-15 1999-11-23 Ep Technologies, Inc. Surface coatings for catheters, direct contacting diagnostic and therapeutic devices
WO1995010225A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Multiple electrode element for mapping and ablating
US5840076A (en) 1996-04-12 1998-11-24 Ep Technologies, Inc. Tissue heating and ablation systems and methods using electrode structures with distally oriented porous regions
US5797903A (en) 1996-04-12 1998-08-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with electrically conductive surfaces
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
JP3400835B2 (ja) 1993-12-20 2003-04-28 テルモ株式会社 副伝導路検出装置
US5441498A (en) 1994-02-16 1995-08-15 Envision Surgical Systems, Inc. Method of using a multimodality probe with extendable bipolar electrodes
US5588962A (en) 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
US5505201A (en) 1994-04-20 1996-04-09 Case Western Reserve University Implantable helical spiral cuff electrode
US5451207A (en) 1994-04-25 1995-09-19 The Regents Of The University Of California Method of coronary plaque removal with bypass and perfusion
US5715819A (en) 1994-05-26 1998-02-10 The Carolinas Heart Institute Microwave tomographic spectroscopy system and method
US5573531A (en) 1994-06-20 1996-11-12 Gregory; Kenton W. Fluid core laser angioscope
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US5505730A (en) 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
CA2194062C (en) 1994-06-27 2005-06-28 Dorin Panescu System for controlling tissue ablation using temperature sensors
ES2216016T3 (es) 1994-06-27 2004-10-16 Boston Scientific Limited Sistemas de control no lineal sobre el calentamiento del tejido corporal y los procedimientos de ablacion.
US5735846A (en) 1994-06-27 1998-04-07 Ep Technologies, Inc. Systems and methods for ablating body tissue using predicted maximum tissue temperature
EP0768842A4 (en) 1994-06-27 1998-05-13 Ep Technologies SYSTEMS AND METHODS FOR TEMPERATURE MEASUREMENT IN THE BODY
WO1996002873A1 (en) 1994-07-19 1996-02-01 Hologram Technology International, Inc. Image recording medium and method of making same
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5967976A (en) 1994-08-19 1999-10-19 Novoste Corporation Apparatus and methods for procedures related to the electrophysiology of the heart
US5531520A (en) 1994-09-01 1996-07-02 Massachusetts Institute Of Technology System and method of registration of three-dimensional data sets including anatomical body data
US6572609B1 (en) 1999-07-14 2003-06-03 Cardiofocus, Inc. Phototherapeutic waveguide apparatus
US8025661B2 (en) 1994-09-09 2011-09-27 Cardiofocus, Inc. Coaxial catheter instruments for ablation with radiant energy
US5647847A (en) 1994-09-16 1997-07-15 Scimed Life Systems, Inc. Balloon catheter with improved pressure source
US5876336A (en) 1994-10-11 1999-03-02 Ep Technologies, Inc. Systems and methods for guiding movable electrode elements within multiple-electrode structure
US5810742A (en) 1994-10-24 1998-09-22 Transcan Research & Development Co., Ltd. Tissue characterization based on impedance images and on impedance measurements
US5571151A (en) 1994-10-25 1996-11-05 Gregory; Kenton W. Method for contemporaneous application of laser energy and localized pharmacologic therapy
US5817144A (en) 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US5643255A (en) 1994-12-12 1997-07-01 Hicor, Inc. Steerable catheter with rotatable tip electrode and method of use
US5665062A (en) 1995-01-23 1997-09-09 Houser; Russell A. Atherectomy catheter and RF cutting method
US5776174A (en) 1995-01-30 1998-07-07 Illumenex Corporation Stabilization of vascular lesions by ultraviolet radiation
FR2729845B1 (fr) 1995-02-01 1997-07-25 Centre Nat Rech Scient Catheter d'imagerie echographique endocavitaire
US6409722B1 (en) 1998-07-07 2002-06-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US6110187A (en) 1995-02-24 2000-08-29 Heartport, Inc. Device and method for minimizing heart displacements during a beating heart surgical procedure
US5904697A (en) 1995-02-24 1999-05-18 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
WO1996026671A1 (en) 1995-02-28 1996-09-06 Boston Scientific Corporation Polymeric implements for torque transmission
US5797849A (en) 1995-03-28 1998-08-25 Sonometrics Corporation Method for carrying out a medical procedure using a three-dimensional tracking and imaging system
US5755753A (en) 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US6430446B1 (en) 1995-05-05 2002-08-06 Thermage, Inc. Apparatus for tissue remodeling
US5660836A (en) 1995-05-05 1997-08-26 Knowlton; Edward W. Method and apparatus for controlled contraction of collagen tissue
US6241753B1 (en) 1995-05-05 2001-06-05 Thermage, Inc. Method for scar collagen formation and contraction
US6425912B1 (en) 1995-05-05 2002-07-30 Thermage, Inc. Method and apparatus for modifying skin surface and soft tissue structure
US6251104B1 (en) 1995-05-10 2001-06-26 Eclipse Surgical Technologies, Inc. Guiding catheter system for ablating heart tissue
US5782760A (en) 1995-05-23 1998-07-21 Cardima, Inc. Over-the-wire EP catheter
US6190379B1 (en) 1995-06-06 2001-02-20 Sun Star Technology, Inc. Hot tip catheter
US5666964A (en) 1995-06-06 1997-09-16 Meilus; Algis A. Muscle treatment devices
US6632193B1 (en) 1995-06-07 2003-10-14 Arthrocare Corporation Systems and methods for electrosurgical tissue treatment
US6293943B1 (en) 1995-06-07 2001-09-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
US5741248A (en) 1995-06-07 1998-04-21 Temple University-Of The Commonwealth System Of Higher Education Fluorochemical liquid augmented cryosurgery
US6837888B2 (en) 1995-06-07 2005-01-04 Arthrocare Corporation Electrosurgical probe with movable return electrode and methods related thereto
US6293942B1 (en) 1995-06-23 2001-09-25 Gyrus Medical Limited Electrosurgical generator method
AU710619B2 (en) 1995-06-23 1999-09-23 Gyrus Medical Limited An electrosurgical instrument
US5702433A (en) 1995-06-27 1997-12-30 Arrow International Investment Corp. Kink-resistant steerable catheter assembly for microwave ablation
US8241217B2 (en) 1995-06-29 2012-08-14 Teratech Corporation Portable ultrasound imaging data
EP0835075A4 (en) 1995-06-30 1999-06-23 Boston Scient Corp CATHETER FOR ULTRASONIC IMAGING, WITH A CUTTING ELEMENT
US5693029A (en) 1995-07-10 1997-12-02 World Medical Manufacturing Corporation Pro-cell intra-cavity therapeutic agent delivery device
US5865801A (en) 1995-07-18 1999-02-02 Houser; Russell A. Multiple compartmented balloon catheter with external pressure sensing
US5800484A (en) 1995-08-15 1998-09-01 Rita Medical Systems, Inc. Multiple antenna ablation apparatus with expanded electrodes
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US6763261B2 (en) 1995-09-20 2004-07-13 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6090618A (en) 1996-10-07 2000-07-18 Arch Development Corporation DNA constructs and viral vectors comprising a smooth muscle promoter
US6190353B1 (en) 1995-10-13 2001-02-20 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
EP1317908B1 (en) 1995-10-13 2011-07-06 Medtronic Vascular, Inc. A device and system for interstitial transvascular intervention
US5846245A (en) 1995-10-20 1998-12-08 New York University Bone-adjusting device
US5817092A (en) 1995-11-09 1998-10-06 Radio Therapeutics Corporation Apparatus, system and method for delivering radio frequency energy to a treatment site
US5833593A (en) 1995-11-09 1998-11-10 United States Surgical Corporation Flexible source wire for localized internal irradiation of tissue
US5906623A (en) 1995-12-11 1999-05-25 Boston Scientific Corporation Lithotripsy system
US6350276B1 (en) 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US5853411A (en) 1996-01-19 1998-12-29 Ep Technologies, Inc. Enhanced electrical connections for electrode structures
US5879348A (en) 1996-04-12 1999-03-09 Ep Technologies, Inc. Electrode structures formed from flexible, porous, or woven materials
US5868736A (en) 1996-04-12 1999-02-09 Ep Technologies, Inc. Systems and methods to control tissue heating or ablation with porous electrode structures
US6071278A (en) 1996-02-28 2000-06-06 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with specified electrical resistivities
US5836874A (en) 1996-04-08 1998-11-17 Ep Technologies, Inc. Multi-function electrode structures for electrically analyzing and heating body tissue
US5925038A (en) 1996-01-19 1999-07-20 Ep Technologies, Inc. Expandable-collapsible electrode structures for capacitive coupling to tissue
US5830213A (en) 1996-04-12 1998-11-03 Ep Technologies, Inc. Systems for heating and ablating tissue using multifunctional electrode structures
US5846238A (en) 1996-01-19 1998-12-08 Ep Technologies, Inc. Expandable-collapsible electrode structures with distal end steering or manipulation
WO1997025919A1 (en) 1996-01-19 1997-07-24 Ep Technologies, Inc. Systems and methods for heating and ablating tissue using multifunctional electrode structures
US5846239A (en) 1996-04-12 1998-12-08 Ep Technologies, Inc. Tissue heating and ablation systems and methods using segmented porous electrode structures
US5871483A (en) 1996-01-19 1999-02-16 Ep Technologies, Inc. Folding electrode structures
US5961513A (en) 1996-01-19 1999-10-05 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures
US5891135A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Stem elements for securing tubing and electrical wires to expandable-collapsible electrode structures
US6475213B1 (en) 1996-01-19 2002-11-05 Ep Technologies, Inc. Method of ablating body tissue
US5891136A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Expandable-collapsible mesh electrode structures
US6579311B1 (en) 1996-02-02 2003-06-17 Transvascular, Inc. Method for interstitial transvascular intervention
US6436056B1 (en) 1996-02-28 2002-08-20 Boston Scientific Corporation Polymeric implements for torque transmission
US6139527A (en) 1996-03-05 2000-10-31 Vnus Medical Technologies, Inc. Method and apparatus for treating hemorrhoids
EP0921765B1 (en) 1996-03-05 2007-05-02 Vnus Medical Technologies, Inc. Vascular catheter-based system for heating tissue
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
US6152899A (en) 1996-03-05 2000-11-28 Vnus Medical Technologies, Inc. Expandable catheter having improved electrode design, and method for applying energy
US6033397A (en) 1996-03-05 2000-03-07 Vnus Medical Technologies, Inc. Method and apparatus for treating esophageal varices
US5843016A (en) 1996-03-18 1998-12-01 Physion S.R.L. Electromotive drug administration for treatment of acute urinary outflow obstruction
US5690681A (en) 1996-03-29 1997-11-25 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US5769880A (en) 1996-04-12 1998-06-23 Novacept Moisture transport system for contact electrocoagulation
US7604633B2 (en) 1996-04-12 2009-10-20 Cytyc Corporation Moisture transport system for contact electrocoagulation
US6813520B2 (en) 1996-04-12 2004-11-02 Novacept Method for ablating and/or coagulating tissue using moisture transport
US6673040B1 (en) 1996-04-16 2004-01-06 Cardeon Corporation System and methods for catheter procedures with circulatory support in high risk patients
US5904709A (en) 1996-04-17 1999-05-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microwave treatment for cardiac arrhythmias
US20020045890A1 (en) 1996-04-24 2002-04-18 The Regents Of The University O F California Opto-acoustic thrombolysis
US6022309A (en) 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US6898454B2 (en) 1996-04-25 2005-05-24 The Johns Hopkins University Systems and methods for evaluating the urethra and the periurethral tissues
AUPN957296A0 (en) 1996-04-30 1996-05-23 Cardiac Crc Nominees Pty Limited A system for simultaneous unipolar multi-electrode ablation
US7022105B1 (en) 1996-05-06 2006-04-04 Novasys Medical Inc. Treatment of tissue in sphincters, sinuses and orifices
US6066139A (en) 1996-05-14 2000-05-23 Sherwood Services Ag Apparatus and method for sterilization and embolization
GB9612993D0 (en) 1996-06-20 1996-08-21 Gyrus Medical Ltd Electrosurgical instrument
US5882346A (en) 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5832228A (en) 1996-07-30 1998-11-03 Itt Industries, Inc. System and method for providing multi-level security in computer devices utilized with non-secure networks
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US6684098B2 (en) 1996-08-16 2004-01-27 Brigham And Women's Hospital, Inc. Versatile stereotactic device and methods of use
US7203537B2 (en) 1996-08-19 2007-04-10 Mr3 Medical, Llc System and method for breaking reentry circuits by cooling cardiac tissue
US5800494A (en) 1996-08-20 1998-09-01 Fidus Medical Technology Corporation Microwave ablation catheters having antennas with distal fire capabilities
US6123679A (en) 1996-08-29 2000-09-26 Lafaut; Jean-Pierre Method for extracorporeal shock wave lithotripsy by applying an acoustic shock wave followed by a limited oscillating acoustic pressure wave train
US5906636A (en) 1996-09-20 1999-05-25 Texas Heart Institute Heat treatment of inflamed tissue
US6451044B1 (en) 1996-09-20 2002-09-17 Board Of Regents, The University Of Texas System Method and apparatus for heating inflammed tissue
US7603166B2 (en) 1996-09-20 2009-10-13 Board Of Regents University Of Texas System Method and apparatus for detection of vulnerable atherosclerotic plaque
US5957941A (en) 1996-09-27 1999-09-28 Boston Scientific Corporation Catheter system and drive assembly thereof
US5971975A (en) 1996-10-09 1999-10-26 Target Therapeutics, Inc. Guide catheter with enhanced guidewire tracking
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US5931834A (en) 1996-10-15 1999-08-03 Eclipse Surgical Technologies, Inc. Method for non-synchronous laser-assisted myocardial revascularization
US5785702A (en) 1996-10-15 1998-07-28 Eclipse Surgical Technologies, Inc. Method for non-synchronous laser-assisted transmyocardial revascularization
US5741249A (en) 1996-10-16 1998-04-21 Fidus Medical Technology Corporation Anchoring tip assembly for microwave ablation catheter
US5810803A (en) 1996-10-16 1998-09-22 Fidus Medical Technology Corporation Conformal positioning assembly for microwave ablation catheter
US6237605B1 (en) 1996-10-22 2001-05-29 Epicor, Inc. Methods of epicardial ablation
US5848969A (en) 1996-10-28 1998-12-15 Ep Technologies, Inc. Systems and methods for visualizing interior tissue regions using expandable imaging structures
US5904651A (en) 1996-10-28 1999-05-18 Ep Technologies, Inc. Systems and methods for visualizing tissue during diagnostic or therapeutic procedures
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US6216704B1 (en) 1997-08-13 2001-04-17 Surx, Inc. Noninvasive devices, methods, and systems for shrinking of tissues
US6081749A (en) 1997-08-13 2000-06-27 Surx, Inc. Noninvasive devices, methods, and systems for shrinking of tissues
US5875782A (en) 1996-11-14 1999-03-02 Cardiothoracic Systems, Inc. Methods and devices for minimally invasive coronary artery revascularization on a beating heart without cardiopulmonary bypass
AU5431898A (en) 1996-11-21 1998-06-10 Boston Scientific Corporation Mucosal ablation using light
US6159187A (en) 1996-12-06 2000-12-12 Target Therapeutics, Inc. Reinforced catheter with a formable distal tip
US5999678A (en) 1996-12-27 1999-12-07 Eclipse Surgical Technologies, Inc. Laser delivery means adapted for drug delivery
CA2225521C (en) 1996-12-27 2004-04-06 Eclipse Surgical Technologies, Inc. Laser assisted drug delivery apparatus
US5775338A (en) 1997-01-10 1998-07-07 Scimed Life Systems, Inc. Heated perfusion balloon for reduction of restenosis
US6342363B1 (en) 1997-01-28 2002-01-29 Human Genome Sciences, Inc. Death domain containing receptor 4 nucleic acids and methods
US7452538B2 (en) 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US8329179B2 (en) 1997-01-28 2012-12-11 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
JP2001512334A (ja) 1997-02-12 2001-08-21 プロリフィックス メディカル，インコーポレイテッド ステントから物質を除去する装置
US5989284A (en) 1997-02-18 1999-11-23 Hearten Medical, Inc. Method and device for soft tissue modification
US6120516A (en) 1997-02-28 2000-09-19 Lumend, Inc. Method for treating vascular occlusion
US5868735A (en) 1997-03-06 1999-02-09 Scimed Life Systems, Inc. Cryoplasty device and method
US7220257B1 (en) 2000-07-25 2007-05-22 Scimed Life Systems, Inc. Cryotreatment device and method
US6032675A (en) 1997-03-17 2000-03-07 Rubinsky; Boris Freezing method for controlled removal of fatty tissue by liposuction
US5904667A (en) 1997-03-17 1999-05-18 C.R. Bard, Inc. Rotatable control mechanism for steerable catheter
US5972026A (en) 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US7425212B1 (en) 1998-06-10 2008-09-16 Asthmatx, Inc. Devices for modification of airways by transfer of energy
US6488673B1 (en) 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US6524299B1 (en) 1997-04-09 2003-02-25 Target Therapeutics, Inc. Flow-directed catheter
WO1998046115A2 (en) 1997-04-11 1998-10-22 Transvascular, Inc. Methods and apparatus for transmyocardial direct coronary revascularization
US5827203A (en) 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
GB9708268D0 (en) 1997-04-24 1997-06-18 Gyrus Medical Ltd An electrosurgical instrument
US6117128A (en) 1997-04-30 2000-09-12 Kenton W. Gregory Energy delivery catheter and method for the use thereof
US6723063B1 (en) 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US5989208A (en) 1997-05-16 1999-11-23 Nita; Henry Therapeutic ultrasound system
US6217576B1 (en) 1997-05-19 2001-04-17 Irvine Biomedical Inc. Catheter probe for treating focal atrial fibrillation in pulmonary veins
US5895378A (en) 1997-05-29 1999-04-20 Target Therapeutics, Inc. Flow-directed catheter having multiple tapers and radio-opaque markers
US5951539A (en) 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
US6152912A (en) 1997-06-10 2000-11-28 Target Therapeutics, Inc. Optimized high performance spiral-wound vascular catheter
US6855143B2 (en) 1997-06-13 2005-02-15 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
CA2287206A1 (en) 1997-06-13 1998-12-17 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
EP0989822A4 (en) 1997-06-23 2004-07-28 Focus Surgery Inc ACOUSTIC HEMOSTASIS METHODS AND DEVICES
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
USRE40279E1 (en) 1997-06-26 2008-04-29 Sherwood Services Ag Method and system for neural tissue modification
US6241666B1 (en) 1997-07-03 2001-06-05 Cardiac Pathways Corp. Ablation catheter tip with a buffer layer covering the electrode
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
ATE433306T1 (de) * 1997-07-08 2009-06-15 Univ California Vorrichtung zur zirkumferenziellen ablation
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6997925B2 (en) 1997-07-08 2006-02-14 Atrionx, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6547788B1 (en) 1997-07-08 2003-04-15 Atrionx, Inc. Medical device with sensor cooperating with expandable member
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US5891138A (en) 1997-08-11 1999-04-06 Irvine Biomedical, Inc. Catheter system having parallel electrodes
US9023031B2 (en) 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
US6402719B1 (en) 1997-09-05 2002-06-11 Cordis Webster, Inc. Steerable DMR catheter with infusion tube
US5964757A (en) 1997-09-05 1999-10-12 Cordis Webster, Inc. Steerable direct myocardial revascularization catheter
US6401719B1 (en) 1997-09-11 2002-06-11 Vnus Medical Technologies, Inc. Method of ligating hollow anatomical structures
US6179832B1 (en) 1997-09-11 2001-01-30 Vnus Medical Technologies, Inc. Expandable catheter having two sets of electrodes
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
US5954717A (en) 1997-09-25 1999-09-21 Radiotherapeutics Corporation Method and system for heating solid tissue
US8257725B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6238389B1 (en) 1997-09-30 2001-05-29 Boston Scientific Corporation Deflectable interstitial ablation device
US5891114A (en) 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
US6007514A (en) 1997-09-30 1999-12-28 Nita; Henry Ultrasound system with pathfinding guidewire
KR100530607B1 (ko) 1997-10-08 2005-11-22 가부시키가이샤 가네가 풍선 카테테르 및 그 제조방법
US6231516B1 (en) 1997-10-14 2001-05-15 Vacusense, Inc. Endoluminal implant with therapeutic and diagnostic capability
US5935063A (en) 1997-10-29 1999-08-10 Irvine Biomedical, Inc. Electrode catheter system and methods thereof
JP2001521774A (ja) 1997-10-31 2001-11-13 シー・アール・バード・インコーポレーテッド 診断用および切除用カテーテルのためのリング状電極構造
US6156046A (en) 1997-11-07 2000-12-05 Prolifix Medical, Inc. Methods and systems for treating obstructions in a body lumen
US6120476A (en) 1997-12-01 2000-09-19 Cordis Webster, Inc. Irrigated tip catheter
US5971979A (en) 1997-12-02 1999-10-26 Odyssey Technologies, Inc. Method for cryogenic inhibition of hyperplasia
DE69921449T2 (de) 1998-01-12 2005-11-24 Ronald P. Lesser Verfahren zur behandlung von hirnleiden mittels gesteuerter wärmezufuhr
AU2114299A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
JP4373605B2 (ja) 1998-01-26 2009-11-25 ボストン サイエンティフィック リミテッド 遠方誘導結合器および埋め込み伝送路を備えたカテーテルアセンブリ
US6447505B2 (en) 1998-02-11 2002-09-10 Cosman Company, Inc. Balloon catheter method for intra-urethral radio-frequency urethral enlargement
US6517534B1 (en) 1998-02-11 2003-02-11 Cosman Company, Inc. Peri-urethral ablation
US6651670B2 (en) 1998-02-13 2003-11-25 Ventrica, Inc. Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication
US7165551B2 (en) 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
EP1059886A2 (en) 1998-03-02 2000-12-20 Atrionix, Inc. Tissue ablation system and method for forming long linear lesion
EP1059887A1 (en) 1998-03-06 2000-12-20 Curon Medical, Inc. Apparatus to electrosurgically treat esophageal sphincters
US6115626A (en) 1998-03-26 2000-09-05 Scimed Life Systems, Inc. Systems and methods using annotated images for controlling the use of diagnostic or therapeutic instruments in instruments in interior body regions
EP1071491A4 (en) 1998-03-30 2004-10-20 Univ Virginia STOP OF THE FLOW, DOUBLE BALLOON TECHNIQUE ALLOWING THE OCCLUSION OF ANNEVRISMS OR BLOOD VESSELS
US6142991A (en) 1998-03-31 2000-11-07 Galil Medical, Ltd. High resolution cryosurgical method and apparatus
US7001378B2 (en) 1998-03-31 2006-02-21 Innercool Therapies, Inc. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US6200266B1 (en) 1998-03-31 2001-03-13 Case Western Reserve University Method and apparatus for ultrasound imaging using acoustic impedance reconstruction
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
AU3212199A (en) 1998-03-31 1999-10-18 Scimed Life Systems, Inc. Temperature controlled solute delivery system
US6666874B2 (en) 1998-04-10 2003-12-23 Endicor Medical, Inc. Rotational atherectomy system with serrated cutting tip
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US20020065542A1 (en) 1998-04-22 2002-05-30 Ronald G. Lax Method and apparatus for treating an aneurysm
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6050994A (en) 1998-05-05 2000-04-18 Cardiac Pacemakers, Inc. RF ablation apparatus and method using controllable duty cycle with alternate phasing
US6558378B2 (en) 1998-05-05 2003-05-06 Cardiac Pacemakers, Inc. RF ablation system and method having automatic temperature control
US6066096A (en) 1998-05-08 2000-05-23 Duke University Imaging probes and catheters for volumetric intraluminal ultrasound imaging and related systems
US6508815B1 (en) 1998-05-08 2003-01-21 Novacept Radio-frequency generator for powering an ablation device
US6022901A (en) 1998-05-13 2000-02-08 Pharmascience Inc. Administration of resveratrol to prevent or treat restenosis following coronary intervention
US7494488B2 (en) 1998-05-28 2009-02-24 Pearl Technology Holdings, Llc Facial tissue strengthening and tightening device and methods
CA2345921C (en) 1998-06-12 2005-01-25 Cardiac Pacemakers, Inc. Modified guidewire for left ventricular access lead
US6121775A (en) 1998-06-16 2000-09-19 Beth Israel Deaconess Medical Center, Inc. MRI imaging method and apparatus
US6292695B1 (en) 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6394096B1 (en) 1998-07-15 2002-05-28 Corazon Technologies, Inc. Method and apparatus for treatment of cardiovascular tissue mineralization
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US5980563A (en) 1998-08-31 1999-11-09 Tu; Lily Chen Ablation apparatus and methods for treating atherosclerosis
US6228109B1 (en) 1998-08-31 2001-05-08 Lily Chen Tu Methods for treating atherosclerosis and vulnerable plaques
US20050080374A1 (en) 1998-09-01 2005-04-14 Brady Esch Method and apparatus for treating acute myocardial infarction with selective hypothermic perfusion
US6251128B1 (en) 1998-09-01 2001-06-26 Fidus Medical Technology Corporation Microwave ablation catheter with loop configuration
US6183468B1 (en) 1998-09-10 2001-02-06 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6489307B1 (en) 1998-09-14 2002-12-03 University Of Florida Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use
US7722539B2 (en) 1998-09-18 2010-05-25 University Of Washington Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue
US6299379B1 (en) 1998-09-18 2001-10-09 Lewis Hunting Accessories, Mfg., Inc. Reflective trail markers
US6425867B1 (en) 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US6123703A (en) 1998-09-19 2000-09-26 Tu; Lily Chen Ablation catheter and methods for treating tissues
US8257724B2 (en) 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6036689A (en) 1998-09-24 2000-03-14 Tu; Lily Chen Ablation device for treating atherosclerotic tissues
EP1115328A4 (en) 1998-09-24 2004-11-10 Super Dimension Ltd SYSTEM AND METHOD FOR LOCATING A CATHETER DURING AN ENDOCORPOREAL MEDICAL EXAMINATION
US20060240070A1 (en) 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
US6319251B1 (en) 1998-09-24 2001-11-20 Hosheng Tu Medical device and methods for treating intravascular restenosis
US6283935B1 (en) 1998-09-30 2001-09-04 Hearten Medical Ultrasonic device for providing reversible tissue damage to heart muscle
US6796981B2 (en) 1999-09-30 2004-09-28 Sherwood Services Ag Vessel sealing system
US7137980B2 (en) 1998-10-23 2006-11-21 Sherwood Services Ag Method and system for controlling output of RF medical generator
US7901400B2 (en) 1998-10-23 2011-03-08 Covidien Ag Method and system for controlling output of RF medical generator
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6673290B1 (en) 1998-11-12 2004-01-06 Scimed Life Systems, Inc. Electrode structure for heating and ablating tissue and method for making and assembling the same
US6210406B1 (en) 1998-12-03 2001-04-03 Cordis Webster, Inc. Split tip electrode catheter and signal processing RF ablation system
US6129725A (en) 1998-12-04 2000-10-10 Tu; Lily Chen Methods for reduction of restenosis
US6078839A (en) 1998-12-09 2000-06-20 Pacesetter, Inc. Abrasion resistant implantable lead insulation protector
EP1140278B1 (en) 1998-12-14 2004-05-19 Tre Esse Progettazione Biomedica S.r.l Catheter system for performing intramyocardiac therapeutic treatment
US20070066972A1 (en) 2001-11-29 2007-03-22 Medwaves, Inc. Ablation catheter apparatus with one or more electrodes
US7066900B2 (en) 1998-12-23 2006-06-27 Life Therapeutics Removal of metabolic components from blood
US6106477A (en) 1998-12-28 2000-08-22 Medtronic, Inc. Chronically implantable blood vessel cuff with sensor
US6296619B1 (en) 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
US6102908A (en) 1999-01-04 2000-08-15 Tu; Lily Chen Rotatable apparatus having ablation capabilities
AU1989100A (en) 1999-01-05 2000-07-24 Kaiku Limited Impedance measurements of bodily matter
US6206831B1 (en) 1999-01-06 2001-03-27 Scimed Life Systems, Inc. Ultrasound-guided ablation catheter and methods of use
US6228076B1 (en) 1999-01-09 2001-05-08 Intraluminal Therapeutics, Inc. System and method for controlling tissue ablation
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US7329236B2 (en) 1999-01-11 2008-02-12 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7481803B2 (en) 2000-11-28 2009-01-27 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US6695830B2 (en) 1999-01-15 2004-02-24 Scimed Life Systems, Inc. Method for delivering medication into an arterial wall for prevention of restenosis
US6191862B1 (en) 1999-01-20 2001-02-20 Lightlab Imaging, Llc Methods and apparatus for high speed longitudinal scanning in imaging systems
US6423057B1 (en) 1999-01-25 2002-07-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method and apparatus for monitoring and controlling tissue temperature and lesion formation in radio-frequency ablation procedures
US6592526B1 (en) 1999-01-25 2003-07-15 Jay Alan Lenker Resolution ultrasound devices for imaging and treatment of body lumens
US6113615A (en) 1999-02-03 2000-09-05 Scimed Life Systems, Inc. Atherectomy burr including a bias wire
US6236883B1 (en) 1999-02-03 2001-05-22 The Trustees Of Columbia University In The City Of New York Methods and systems for localizing reentrant circuits from electrogram features
US6203537B1 (en) 1999-02-04 2001-03-20 Sorin Adrian Laser-driven acoustic ablation catheter
WO2000047118A1 (en) 1999-02-10 2000-08-17 Swaminathan Jayaraman Balloon catheter for cryotherapy and method of using same
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
CA2362332A1 (en) 1999-02-19 2000-08-24 Scimed Life Systems, Inc. Laser lithotripsy device with suction
US6648879B2 (en) 1999-02-24 2003-11-18 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6468297B1 (en) 1999-02-24 2002-10-22 Cryovascular Systems, Inc. Cryogenically enhanced intravascular interventions
US6428534B1 (en) 1999-02-24 2002-08-06 Cryovascular Systems, Inc. Cryogenic angioplasty catheter
US6514245B1 (en) 1999-03-15 2003-02-04 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6432102B2 (en) 1999-03-15 2002-08-13 Cryovascular Systems, Inc. Cryosurgical fluid supply
ATE298536T1 (de) 1999-03-09 2005-07-15 Thermage Inc Vorichtung zur behandlung von gewebe
US6484052B1 (en) 1999-03-30 2002-11-19 The Regents Of The University Of California Optically generated ultrasound for enhanced drug delivery
US6911026B1 (en) 1999-07-12 2005-06-28 Stereotaxis, Inc. Magnetically guided atherectomy
US6409723B1 (en) 1999-04-02 2002-06-25 Stuart D. Edwards Treating body tissue by applying energy and substances
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US20010007070A1 (en) 1999-04-05 2001-07-05 Medtronic, Inc. Ablation catheter assembly and method for isolating a pulmonary vein
US20050010095A1 (en) 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
WO2000062672A1 (en) 1999-04-15 2000-10-26 Surgi-Vision Methods for in vivo magnetic resonance imaging
US6577902B1 (en) 1999-04-16 2003-06-10 Tony R. Brown Device for shaping infarcted heart tissue and method of using the device
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6149647A (en) 1999-04-19 2000-11-21 Tu; Lily Chen Apparatus and methods for tissue treatment
US6245045B1 (en) 1999-04-23 2001-06-12 Alexander Andrew Stratienko Combination sheath and catheter for cardiovascular use
US6514236B1 (en) 1999-04-23 2003-02-04 Alexander A. Stratienko Method for treating a cardiovascular condition
US6595959B1 (en) 1999-04-23 2003-07-22 Alexander A. Stratienko Cardiovascular sheath/catheter
JP2002543684A (ja) 1999-04-26 2002-12-17 シマゲ オユ 放射線撮像線用自己トリガー撮像デバイス
US6689142B1 (en) 1999-04-26 2004-02-10 Scimed Life Systems, Inc. Apparatus and methods for guiding a needle
US7226446B1 (en) 1999-05-04 2007-06-05 Dinesh Mody Surgical microwave ablation assembly
US6648854B1 (en) 1999-05-14 2003-11-18 Scimed Life Systems, Inc. Single lumen balloon-tipped micro catheter with reinforced shaft
US6692490B1 (en) 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
US7343195B2 (en) 1999-05-18 2008-03-11 Mediguide Ltd. Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation
EP1180004A1 (en) 1999-05-18 2002-02-20 Silhouette Medical Inc. Surgical weight control device
GB9911956D0 (en) 1999-05-21 1999-07-21 Gyrus Medical Ltd Electrosurgery system and method
US6375668B1 (en) 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
US6391024B1 (en) 1999-06-17 2002-05-21 Cardiac Pacemakers, Inc. RF ablation apparatus and method having electrode/tissue contact assessment scheme and electrocardiogram filtering
US6398792B1 (en) 1999-06-21 2002-06-04 O'connor Lawrence Angioplasty catheter with transducer using balloon for focusing of ultrasonic energy and method for use
SE519023C2 (sv) 1999-06-21 2002-12-23 Micromuscle Ab Kateterburna mikrokirurgiska verktygsset
US6546272B1 (en) 1999-06-24 2003-04-08 Mackinnon Nicholas B. Apparatus for in vivo imaging of the respiratory tract and other internal organs
US7426409B2 (en) 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US7840278B1 (en) 1999-06-25 2010-11-23 Puskas John D Devices and methods for vagus nerve stimulation
US6238392B1 (en) 1999-06-29 2001-05-29 Ethicon Endo-Surgery, Inc. Bipolar electrosurgical instrument including a plurality of balloon electrodes
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6508804B2 (en) 1999-07-28 2003-01-21 Scimed Life Systems, Inc. Catheter having continuous lattice and coil reinforcement
US6203561B1 (en) 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US7033372B1 (en) 1999-08-04 2006-04-25 Percardia, Inc. Corkscrew reinforced left ventricle to coronary artery channel
US6235044B1 (en) 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
DE29913688U1 (de) 1999-08-05 1999-10-14 Wolf Gmbh Richard Transurethrale Dissektionselektrode
ATE258768T1 (de) 1999-08-05 2004-02-15 Broncus Tech Inc Verfahren und vorrichtungen zur herstellung von kollateralen kanälen in den lungen
FR2797389B1 (fr) 1999-08-09 2001-11-30 Novatech Inc Prothese aortique bifurquee
US6445939B1 (en) 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
US7288096B2 (en) 2003-01-17 2007-10-30 Origin Medsystems, Inc. Apparatus for placement of cardiac defibrillator and pacer
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
US6283959B1 (en) 1999-08-23 2001-09-04 Cyrocath Technologies, Inc. Endovascular cryotreatment catheter
US6298256B1 (en) 1999-09-10 2001-10-02 Frank-Egbert Meyer Device and method for the location and catheterization of the surroundings of a nerve
NL1013084C2 (nl) 1999-09-17 2001-03-20 Neopost Bv Instellen van een systeem voor het samenstellen van poststukken.
US6454775B1 (en) 1999-12-06 2002-09-24 Bacchus Vascular Inc. Systems and methods for clot disruption and retrieval
US6829497B2 (en) 1999-09-21 2004-12-07 Jamil Mogul Steerable diagnostic catheters
JP2003510126A (ja) 1999-09-28 2003-03-18 ノヴァシス メディカル インコーポレイテッド エネルギーと薬の適用による組織の処置
US6485489B2 (en) 1999-10-02 2002-11-26 Quantum Cor, Inc. Catheter system for repairing a mitral valve annulus
US6514248B1 (en) 1999-10-15 2003-02-04 Neothermia Corporation Accurate cutting about and into tissue volumes with electrosurgically deployed electrodes
JP2001116565A (ja) 1999-10-15 2001-04-27 Yazaki Corp 車載ナビゲーション装置及び車載ナビゲーション装置における処理プログラムを記録した記録媒体
US6669655B1 (en) 1999-10-20 2003-12-30 Transurgical, Inc. Sonic element and catheter incorporating same
EP1229839A4 (en) 1999-10-25 2005-12-07 Therus Corp USING FOCUSED ULTRASOUND FOR VASCULAR SEALING
ES2299447T3 (es) 1999-11-10 2008-06-01 Cytyc Surgical Products Sistema para detectar perforaciones en una cavidad corporal.
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6529756B1 (en) 1999-11-22 2003-03-04 Scimed Life Systems, Inc. Apparatus for mapping and coagulating soft tissue in or around body orifices
EP1237472A4 (en) 1999-11-24 2008-04-30 Nuvasive Inc SLEKTROMYOGRAPHIESYSTEM
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US7097641B1 (en) 1999-12-09 2006-08-29 Cryocath Technologies Inc. Catheter with cryogenic and heating ablation
US6800075B2 (en) 1999-12-10 2004-10-05 Sprite Solutions Method to inject and extract fluid at a treatment site to remove debris
US7494485B2 (en) 1999-12-10 2009-02-24 Sprite Solutions Fluidic interventional device and method of distal protection
US6480745B2 (en) 1999-12-24 2002-11-12 Medtronic, Inc. Information network interrogation of an implanted device
US6494891B1 (en) 1999-12-30 2002-12-17 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty transmission member
US6440125B1 (en) 2000-01-04 2002-08-27 Peter Rentrop Excimer laser catheter
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US6447443B1 (en) 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US6623453B1 (en) 2000-01-19 2003-09-23 Vanny Corporation Chemo-thermo applicator for cancer treatment
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US6692450B1 (en) 2000-01-19 2004-02-17 Medtronic Xomed, Inc. Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same
US7184827B1 (en) 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
US6569109B2 (en) 2000-02-04 2003-05-27 Olympus Optical Co., Ltd. Ultrasonic operation apparatus for performing follow-up control of resonance frequency drive of ultrasonic oscillator by digital PLL system using DDS (direct digital synthesizer)
US6457365B1 (en) 2000-02-09 2002-10-01 Endosonics Corporation Method and apparatus for ultrasonic imaging
US6663622B1 (en) 2000-02-11 2003-12-16 Iotek, Inc. Surgical devices and methods for use in tissue ablation procedures
US6158250A (en) 2000-02-14 2000-12-12 Novacept Flat-bed knitting machine and method of knitting
US7499745B2 (en) 2000-02-28 2009-03-03 Barbara Ann Karmanos Cancer Institute Multidimensional bioelectrical tissue analyzer
US6394956B1 (en) 2000-02-29 2002-05-28 Scimed Life Systems, Inc. RF ablation and ultrasound catheter for crossing chronic total occlusions
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6458098B1 (en) 2000-03-17 2002-10-01 Nozomu Kanesaka Vascular therapy device
WO2001072373A2 (en) 2000-03-24 2001-10-04 Transurgical, Inc. Apparatus and method for intrabody thermal treatment
US6471696B1 (en) 2000-04-12 2002-10-29 Afx, Inc. Microwave ablation instrument with a directional radiation pattern
AU2001253654A1 (en) 2000-04-27 2001-11-12 Medtronic, Inc. Vibration sensitive ablation apparatus and method
US20020107514A1 (en) 2000-04-27 2002-08-08 Hooven Michael D. Transmural ablation device with parallel jaws
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
EP1642544B1 (en) 2000-05-03 2009-04-08 C.R.Bard, Inc. Apparatus for mapping and ablation in electrophysiology procedures
WO2001087172A1 (en) 2000-05-12 2001-11-22 Cardima, Inc. Multi-channel rf energy delivery with coagulum reduction
US7252664B2 (en) 2000-05-12 2007-08-07 Cardima, Inc. System and method for multi-channel RF energy delivery with coagulum reduction
US7006858B2 (en) 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US6760616B2 (en) 2000-05-18 2004-07-06 Nu Vasive, Inc. Tissue discrimination and applications in medical procedures
US6544780B1 (en) 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
US6511500B1 (en) 2000-06-06 2003-01-28 Marc Mounir Rahme Use of autonomic nervous system neurotransmitters inhibition and atrial parasympathetic fibers ablation for the treatment of atrial arrhythmias and to preserve drug effects
US20020022864A1 (en) 2000-06-07 2002-02-21 Mahvi David M. Multipolar electrode system for radiofrequency ablation
ATE290827T1 (de) 2000-06-13 2005-04-15 Atrionix Inc Chirurgische ablationssonde zum formen einer ringförmigen läsion
US7837720B2 (en) 2000-06-20 2010-11-23 Boston Scientific Corporation Apparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon
US6477426B1 (en) 2000-06-20 2002-11-05 Celsion Corporation System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors
US6958075B2 (en) 2001-09-18 2005-10-25 Celsion Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
MXPA03000014A (es) 2000-06-28 2004-09-13 Ira Sanders Metodos para utilizar con fines beneficiosos toxina tetanica en animales.
US6511478B1 (en) 2000-06-30 2003-01-28 Scimed Life Systems, Inc. Medical probe with reduced number of temperature sensor wires
US6638277B2 (en) 2000-07-06 2003-10-28 Scimed Life Systems, Inc. Tumor ablation needle with independently activated and independently traversing tines
US20020095197A1 (en) 2000-07-11 2002-07-18 Lardo Albert C. Application of photochemotherapy for the treatment of cardiac arrhythmias
US6635054B2 (en) 2000-07-13 2003-10-21 Transurgical, Inc. Thermal treatment methods and apparatus with focused energy application
DE10038737A1 (de) 2000-08-02 2002-02-14 Oliver Wendt Katheter für magnetresonanztomographische Untersuchungen
US7678106B2 (en) 2000-08-09 2010-03-16 Halt Medical, Inc. Gynecological ablation procedure and system
US6699241B2 (en) 2000-08-11 2004-03-02 Northeastern University Wide-aperture catheter-based microwave cardiac ablation antenna
US7789876B2 (en) 2000-08-14 2010-09-07 Tyco Healthcare Group, Lp Method and apparatus for positioning a catheter relative to an anatomical junction
US6497711B1 (en) 2000-08-16 2002-12-24 Scimed Life Systems, Inc. Therectomy device having a light weight drive shaft and an imaging device
US20040010118A1 (en) 2000-08-16 2004-01-15 Zerhusen Bryan D. Novel proteins and nucleic acids encoding same
US6602246B1 (en) 2000-08-18 2003-08-05 Cryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6955174B2 (en) 2000-08-18 2005-10-18 Uryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6669692B1 (en) 2000-08-21 2003-12-30 Biosense Webster, Inc. Ablation catheter with cooled linear electrode
CN1466466A (zh) 2000-09-08 2004-01-07 ��һ��������ҩ��ʽ���� 心衰治疗剂
US6511496B1 (en) 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6985774B2 (en) 2000-09-27 2006-01-10 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US6470219B1 (en) 2000-10-02 2002-10-22 Novasys Medical, Inc. Apparatus and method for treating female urinary incontinence
US6640120B1 (en) 2000-10-05 2003-10-28 Scimed Life Systems, Inc. Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US6527765B2 (en) 2000-10-06 2003-03-04 Charles D. Kelman Cryogenic surgical system and method of use in removal of tissue
US6802857B1 (en) 2000-10-11 2004-10-12 Uab Research Foundation MRI stent
US6475215B1 (en) 2000-10-12 2002-11-05 Naim Erturk Tanrisever Quantum energy surgical device and method
US7104987B2 (en) 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US7646544B2 (en) 2005-05-14 2010-01-12 Batchko Robert G Fluidic optical devices
US6706037B2 (en) 2000-10-24 2004-03-16 Galil Medical Ltd. Multiple cryoprobe apparatus and method
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US20060062786A1 (en) 2000-11-08 2006-03-23 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20070292411A1 (en) 2000-11-08 2007-12-20 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US6673066B2 (en) 2000-11-10 2004-01-06 Cardiostream, Inc. Apparatus and method to diagnose and treat vulnerable plaque
AU2001263143B2 (en) 2000-11-16 2006-12-07 Covidien Lp System and method of treating abnormal tissue in the human esophagus
US7314483B2 (en) 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US6942692B2 (en) 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
WO2002045588A1 (de) 2000-11-24 2002-06-13 Innovacell Biotechnologie Gmbh Ultraschallsonde mit positioniereinrichtung für untersuchungs- und operationsvorrichtungen
US6579308B1 (en) 2000-11-28 2003-06-17 Scimed Life Systems, Inc. Stent devices with detachable distal or proximal wires
US7081114B2 (en) 2000-11-29 2006-07-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having lariat configuration of variable radius
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US6659981B2 (en) 2000-12-08 2003-12-09 Medtronic, Inc. Medical device delivery catheter with distal locator
US6623452B2 (en) 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US20020087151A1 (en) 2000-12-29 2002-07-04 Afx, Inc. Tissue ablation apparatus with a sliding ablation instrument and method
DE60238178D1 (de) 2001-01-16 2010-12-16 Cytyc Surgical Products Palo A Vorrichtung und verfahren zur behandlung des venösen reflux
US6569177B1 (en) 2001-01-19 2003-05-27 Scimed Life Systems, Inc. Ablation atherectomy burr
AU2002236790B2 (en) 2001-01-19 2006-08-17 Boston Scientific Limited Introducer for deployment of branched prosthesis
US20020107536A1 (en) 2001-02-07 2002-08-08 Hussein Hany M. Device and method for preventing kidney failure
US6823205B1 (en) 2001-02-08 2004-11-23 Boston University Radiology Associates Synthetic images for a magnetic resonance imaging scanner using linear combination of source images to generate contrast and spatial navigation
CN1496271B (zh) 2001-02-16 2010-04-28 阿斯比奥制药株式会社 伴随有aop-1基因或aop-1的表达减少的疾病的治疗方法以及该疾病的治疗药
AUPR333301A0 (en) 2001-02-23 2001-03-22 Northern Sydney Area Health Service Determining the volume of a normal heart and its pathological and treated variants by using dimension sensors
US6702763B2 (en) 2001-02-28 2004-03-09 Chase Medical, L.P. Sizing apparatus and method for use during ventricular restoration
US6564096B2 (en) 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
US6666863B2 (en) 2001-03-01 2003-12-23 Scimed Life Systems, Inc. Device and method for percutaneous myocardial revascularization
US6786904B2 (en) 2002-01-10 2004-09-07 Triton Biosystems, Inc. Method and device to treat vulnerable plaque
AU2002309117A1 (en) 2001-03-08 2002-11-05 Avtandil Koridze Alkane and alkane group dehydrogenation with organometallic catalysts
US6570659B2 (en) 2001-03-16 2003-05-27 Lightlab Imaging, Llc Broadband light source system and method and light source combiner
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
US20020147480A1 (en) 2001-04-04 2002-10-10 Mamayek Donald S. Treatment of lipid pool
US6552796B2 (en) 2001-04-06 2003-04-22 Lightlab Imaging, Llc Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography
US6764501B2 (en) 2001-04-10 2004-07-20 Robert A. Ganz Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US6666858B2 (en) 2001-04-12 2003-12-23 Scimed Life Systems, Inc. Cryo balloon for atrial ablation
US20050232921A1 (en) 2001-04-13 2005-10-20 Rosen Craig A Vascular endothelial growth factor 2
US7402312B2 (en) 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
US6989010B2 (en) 2001-04-26 2006-01-24 Medtronic, Inc. Ablation system and method of use
US6645223B2 (en) 2001-04-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Deployment and recovery control systems for embolic protection devices
EP1418972A1 (en) 2001-05-01 2004-05-19 C.R. Bard, Inc. Method and apparatus for altering conduction properties along pathways in the heart and in vessels in conductive communication with the heart
US6972016B2 (en) * 2001-05-01 2005-12-06 Cardima, Inc. Helically shaped electrophysiology catheter
US20020169444A1 (en) 2001-05-08 2002-11-14 Mest Robert A. Catheter having continuous braided electrode
US7160296B2 (en) 2001-05-10 2007-01-09 Rita Medical Systems, Inc. Tissue ablation apparatus and method
US20030130713A1 (en) 2001-05-21 2003-07-10 Stewart Mark T. Trans-septal catheter with retention mechanism
US6771996B2 (en) 2001-05-24 2004-08-03 Cardiac Pacemakers, Inc. Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination
US20050214210A1 (en) 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20090226429A1 (en) 2001-05-25 2009-09-10 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US20050214209A1 (en) 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20050129616A1 (en) 2001-05-25 2005-06-16 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
AU2002344234B2 (en) 2001-05-31 2007-11-08 Miravant Pharmaceuticals, Inc. Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
US20020198520A1 (en) 2001-06-20 2002-12-26 Scimed Life Systems, Inc. Irrigation sheath
US6797933B1 (en) 2001-06-29 2004-09-28 Vanguard International Semiconductor Corporation On-chip design-for-testing structure for CMOS APS (active pixel sensor) image sensor
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US20040043030A1 (en) 2001-07-31 2004-03-04 Immunomedics, Inc. Polymeric delivery systems
WO2003013368A1 (en) 2001-08-08 2003-02-20 Canica Design Inc. Surgical retractor and tissue stabilization device
US6786900B2 (en) 2001-08-13 2004-09-07 Cryovascular Systems, Inc. Cryotherapy methods for treating vessel dissections and side branch occlusion
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US8287524B2 (en) 2001-08-23 2012-10-16 Jerry Siegel Apparatus and method for performing radiation energy treatments
WO2003017745A2 (en) 2001-08-23 2003-03-06 Sciperio, Inc. Architecture tool and methods of use
DE60203806T2 (de) 2001-08-31 2005-10-06 Boston Scientific Ltd., St. Michael Perkutane pringle-okklusionsvorrichtung
US6962584B1 (en) 2001-09-06 2005-11-08 Stone Gregg W Electromagnetic photonic catheter for reducing restenosis
US7252679B2 (en) 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
US20030065317A1 (en) 2001-09-19 2003-04-03 Rudie Eric N. Microwave ablation device
JP2005527474A (ja) 2001-09-20 2005-09-15 コーネル リサーチ ファンデーション インコーポレーテッド 前立腺特異的膜抗原に特異的な結合剤を用いて、皮膚障害を治療するかまたは防止するための方法および組成物
US6723043B2 (en) 2001-09-25 2004-04-20 Sdgi Holdings, Inc. Methods and devices for inserting and manipulating surgical instruments
JP3607231B2 (ja) 2001-09-28 2005-01-05 有限会社日本エレクテル 高周波加温バルーンカテーテル
EP1429678B1 (en) 2001-09-28 2006-03-22 Rita Medical Systems, Inc. Impedance controlled tissue ablation apparatus
JP2003111848A (ja) 2001-10-05 2003-04-15 Nihon Medix 加熱式バルーンカテーテル装置およびその加熱方法
CA2462968C (en) 2001-10-06 2012-11-20 Medos S.A. Method of setting and actuating a multi-stable micro valve and adjustable micro valve
US6814730B2 (en) 2001-10-09 2004-11-09 Hong Li Balloon catheters for non-continuous lesions
US6926716B2 (en) 2001-11-09 2005-08-09 Surgrx Inc. Electrosurgical instrument
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
US6807444B2 (en) 2001-11-05 2004-10-19 Hosheng Tu Apparatus and methods for monitoring tissue impedance
US20030092995A1 (en) 2001-11-13 2003-05-15 Medtronic, Inc. System and method of positioning implantable medical devices
US7317077B2 (en) 2001-11-16 2008-01-08 Nymox Pharmaceutical Corporation Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
WO2003043685A2 (en) 2001-11-19 2003-05-30 Cardiovascular Systems, Inc High torque, low profile intravascular guidewire system
US6895077B2 (en) 2001-11-21 2005-05-17 University Of Massachusetts Medical Center System and method for x-ray fluoroscopic imaging
WO2007136946A2 (en) 2001-12-03 2007-11-29 Xtent, Inc. Delivery catheter having active engagement mechanism for prosthesis
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US6849075B2 (en) 2001-12-04 2005-02-01 Estech, Inc. Cardiac ablation devices and methods
US20050149069A1 (en) 2001-12-04 2005-07-07 Bertolero Arthur A. Left atrial appendage devices and methods
US6709431B2 (en) 2001-12-18 2004-03-23 Scimed Life Systems, Inc. Cryo-temperature monitoring
US20050214205A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
AU2002361784A1 (en) 2001-12-20 2003-07-09 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US20050214208A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20050214207A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind toTRAIL receptors
US6972024B1 (en) 2001-12-21 2005-12-06 Advanced Cardiovascular Systems, Inc. Method of treating vulnerable plaque
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
US7326237B2 (en) 2002-01-08 2008-02-05 Cordis Corporation Supra-renal anchoring prosthesis
DE60336534D1 (de) 2002-01-11 2011-05-12 Gen Hospital Corp Vorrichtung zur OCT Bildaufnahme mit axialem Linienfokus für verbesserte Auflösung und Tiefenschärfe
US6790206B2 (en) 2002-01-31 2004-09-14 Scimed Life Systems, Inc. Compensation for power variation along patient cables
US6814733B2 (en) 2002-01-31 2004-11-09 Biosense, Inc. Radio frequency pulmonary vein isolation
US6826830B2 (en) 2002-02-05 2004-12-07 International Business Machines Corporation Multi-layered interconnect structure using liquid crystalline polymer dielectric
US6949121B1 (en) 2002-02-07 2005-09-27 Sentient Engineering & Technology, Llc Apparatus and methods for conduits and materials
MXPA04007897A (es) 2002-02-15 2004-11-26 Celsion Corp Metodo y aparato para tratar el tejido adyacente a un conducto corporal con termocompresion y farmacos.
US7192427B2 (en) 2002-02-19 2007-03-20 Afx, Inc. Apparatus and method for assessing transmurality of a tissue ablation
PL375045A1 (en) 2002-02-21 2005-11-14 Wyeth Gasp1: a follistatin domain containing protein
US7294127B2 (en) 2002-03-05 2007-11-13 Baylis Medical Company Inc. Electrosurgical tissue treatment method
US6824516B2 (en) 2002-03-11 2004-11-30 Medsci Technologies, Inc. System for examining, mapping, diagnosing, and treating diseases of the prostate
ATE369084T1 (de) 2002-03-15 2007-08-15 Bard Inc C R Apparat zur steuerung von ablationsenergie und elektrogrammaufnahme mittels einer vielzahl gemeinsamer elektroden in einem elektrophysiologie-katheter
ITBS20020039U1 (it) 2002-03-20 2003-09-22 Fogazzi Di Venturelli Andrea & Catetere con elettrodo flessibile raffreddato
WO2003079887A2 (en) 2002-03-21 2003-10-02 Radiant Medical, Inc. Measuring blood flow rate or cardiac output
US6979420B2 (en) 2002-03-28 2005-12-27 Scimed Life Systems, Inc. Method of molding balloon catheters employing microwave energy
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US20050256398A1 (en) 2004-05-12 2005-11-17 Hastings Roger N Systems and methods for interventional medicine
US6685733B1 (en) 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
DE10217559B4 (de) 2002-04-19 2004-02-19 Universitätsklinikum Freiburg Vorrichtung zur minimalinvasiven, intravasalen Aortenklappenextraktion
US20030199747A1 (en) 2002-04-19 2003-10-23 Michlitsch Kenneth J. Methods and apparatus for the identification and stabilization of vulnerable plaque
US6989009B2 (en) 2002-04-19 2006-01-24 Scimed Life Systems, Inc. Cryo balloon
US6746401B2 (en) 2002-05-06 2004-06-08 Scimed Life Systems, Inc. Tissue ablation visualization
EP1508157B1 (en) 2002-05-08 2011-11-23 Phoseon Technology, Inc. High efficiency solid-state light source and methods of use and manufacture
AUPS226402A0 (en) 2002-05-13 2002-06-13 Advanced Metal Coatings Pty Limited An ablation catheter
US6746474B2 (en) 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
US7153315B2 (en) 2002-06-11 2006-12-26 Boston Scientific Scimed, Inc. Catheter balloon with ultrasonic microscalpel blades
EP1517651B1 (en) 2002-06-28 2010-05-26 Cook Incorporated Thoracic aortic aneurysm stent graft
GB2390545B (en) 2002-07-09 2005-04-20 Barts & London Nhs Trust Hollow organ probe
US7769427B2 (en) 2002-07-16 2010-08-03 Magnetics, Inc. Apparatus and method for catheter guidance control and imaging
US6866662B2 (en) 2002-07-23 2005-03-15 Biosense Webster, Inc. Ablation catheter having stabilizing array
WO2004011076A2 (en) 2002-07-25 2004-02-05 Boston Scientific Limited Medical device for navigation through anatomy and method of making same
US8920826B2 (en) 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
US6702748B1 (en) 2002-09-20 2004-03-09 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
TWI235073B (en) 2002-08-20 2005-07-01 Toray Industries Catheter for treating cardiac arrhythmias
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US7137963B2 (en) 2002-08-26 2006-11-21 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
US6929639B2 (en) 2002-08-30 2005-08-16 Scimed Life Systems, Inc. Cryo ablation coil
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
WO2005037105A1 (en) 2002-09-20 2005-04-28 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
US7282213B2 (en) 2002-09-30 2007-10-16 Medtronic, Inc. Method for applying a drug coating to a medical device
EP1405613B1 (en) 2002-10-04 2006-03-22 Sorin Biomedica Cardio S.R.L. An implant device for treating aneurisms of the abdominal aorta
US6673101B1 (en) 2002-10-09 2004-01-06 Endovascular Technologies, Inc. Apparatus and method for deploying self-expanding stents
US7493154B2 (en) 2002-10-23 2009-02-17 Medtronic, Inc. Methods and apparatus for locating body vessels and occlusions in body vessels
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US7599730B2 (en) 2002-11-19 2009-10-06 Medtronic Navigation, Inc. Navigation system for cardiac therapies
US6926713B2 (en) 2002-12-11 2005-08-09 Boston Scientific Scimed, Inc. Angle indexer for medical devices
KR100887669B1 (ko) 2002-12-28 2009-03-11 엘지디스플레이 주식회사 액정표시장치 및 그 제조방법
US20050154277A1 (en) 2002-12-31 2005-07-14 Jing Tang Apparatus and methods of using built-in micro-spectroscopy micro-biosensors and specimen collection system for a wireless capsule in a biological body in vivo
EP1583569A4 (en) 2003-01-03 2009-05-06 Ekos Corp ULTRASONIC CATHETER COMPRISING AN AXIAL ENERGY FIELD
US6847848B2 (en) 2003-01-07 2005-01-25 Mmtc, Inc Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
US7083612B2 (en) 2003-01-15 2006-08-01 Cryodynamics, Llc Cryotherapy system
US7087051B2 (en) 2003-01-15 2006-08-08 Boston Scientific Scimed, Inc. Articulating radio frequency probe handle
US6960207B2 (en) 2003-01-21 2005-11-01 St Jude Medical, Daig Division, Inc. Ablation catheter having a virtual electrode comprising portholes and a porous conductor
US7819866B2 (en) 2003-01-21 2010-10-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter and electrode
JP4067976B2 (ja) 2003-01-24 2008-03-26 有限会社日本エレクテル 高周波加温バルーンカテーテル
AU2004208580A1 (en) 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
US20040193211A1 (en) 2003-02-14 2004-09-30 Voegele James W. Fingertip surgical instruments
US7201749B2 (en) 2003-02-19 2007-04-10 Biosense, Inc. Externally-applied high intensity focused ultrasound (HIFU) for pulmonary vein isolation
WO2004073505A2 (en) 2003-02-20 2004-09-02 Prorhythm, Inc. Cardiac ablation devices
US9603545B2 (en) 2003-02-21 2017-03-28 3Dt Holdings, Llc Devices, systems, and methods for removing targeted lesions from vessels
US7818053B2 (en) 2003-02-21 2010-10-19 Dtherapeutics, Llc Devices, systems and methods for plaque type determination
US8465452B2 (en) 2003-02-21 2013-06-18 3Dt Holdings, Llc Devices, systems, and methods for removing stenotic lesions from vessels
US20040167506A1 (en) 2003-02-25 2004-08-26 Scimed Life Systems, Inc. Medical devices employing ferromagnetic heating
DE10308383A1 (de) 2003-02-27 2004-09-16 Storz Endoskop Produktions Gmbh Verfahren und optisches System zur Vermessung der Topographie eines Meßobjekts
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US20050015125A1 (en) 2003-03-14 2005-01-20 Mioduski Paul C. Hyperthermia treatment systems and methods
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US6953425B2 (en) 2003-04-25 2005-10-11 Medtronic Vascular, Inc. Method of treating vulnerable plaque using a catheter-based radiation system
US7597704B2 (en) 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US20040243022A1 (en) 2003-04-29 2004-12-02 Medtronic Vascular, Inc. Method and system of detecting vulnerable plaque by sensing motion of thin fibrous cap
US7279600B2 (en) 2003-05-02 2007-10-09 Wyeth Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents
WO2004098694A1 (en) 2003-05-02 2004-11-18 Boston Scientific Limited Multi-functional medical catheter
CN100344610C (zh) 2003-05-16 2007-10-24 惠氏公司 芳基－甲醛肟衍生物及其作为雌激素药物的用途
JP2004337400A (ja) 2003-05-16 2004-12-02 Terumo Corp 薬剤投与キット
CL2004000985A1 (es) 2003-05-16 2005-01-14 Wyeth Corp Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc
US7758520B2 (en) 2003-05-27 2010-07-20 Boston Scientific Scimed, Inc. Medical device having segmented construction
US7285120B2 (en) 2003-05-27 2007-10-23 Venture Manufacturing, Llc Balloon centered radially expanding ablation device
US6932776B2 (en) 2003-06-02 2005-08-23 Meridian Medicalssystems, Llc Method and apparatus for detecting and treating vulnerable plaques
US7529589B2 (en) 2003-06-04 2009-05-05 Synecor Llc Intravascular electrophysiological system and methods
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
WO2004110258A2 (en) 2003-06-10 2004-12-23 Cardiofocus, Inc. Guided cardiac ablation catheters
US20080208169A1 (en) 2003-06-11 2008-08-28 Boyle Edward M Jr Body-Space Treatment Catheter
US7112196B2 (en) 2003-06-13 2006-09-26 Piezo Technologies, Inc. Multi-element array for acoustic ablation
DE10328816A1 (de) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
US7066895B2 (en) 2003-06-30 2006-06-27 Ethicon, Inc. Ultrasonic radial focused transducer for pulmonary vein ablation
US7678104B2 (en) 2003-07-17 2010-03-16 Biosense Webster, Inc. Ultrasound ablation catheter and method for its use
US7670335B2 (en) 2003-07-21 2010-03-02 Biosense Webster, Inc. Ablation device with spiral array ultrasound transducer
US7479157B2 (en) 2003-08-07 2009-01-20 Boston Scientific Scimed, Inc. Stent designs which enable the visibility of the inside of the stent during MRI
US7250440B2 (en) 2003-08-12 2007-07-31 Wyeth (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
US7294125B2 (en) 2003-08-22 2007-11-13 Scimed Life Systems, Inc. Methods of delivering energy to body portions to produce a therapeutic response
US7313430B2 (en) 2003-08-28 2007-12-25 Medtronic Navigation, Inc. Method and apparatus for performing stereotactic surgery
EP3045136B1 (en) 2003-09-12 2021-02-24 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US7569052B2 (en) 2003-09-12 2009-08-04 Boston Scientific Scimed, Inc. Ablation catheter with tissue protecting assembly
US7736362B2 (en) 2003-09-15 2010-06-15 Boston Scientific Scimed, Inc. Catheter balloons
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US7280863B2 (en) 2003-10-20 2007-10-09 Magnetecs, Inc. System and method for radar-assisted catheter guidance and control
US7480532B2 (en) 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
KR100573976B1 (ko) 2003-10-28 2006-04-26 삼성전자주식회사 전사벨트의 구동방법
EP1691852A2 (en) 2003-11-10 2006-08-23 Angiotech International AG Medical implants and fibrosis-inducing agents
EP1689457A2 (en) 2003-11-10 2006-08-16 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
WO2005046516A2 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and anti-scarring agents
US7367970B2 (en) 2003-11-11 2008-05-06 Biosense Webster Inc. Externally applied RF for pulmonary vein isolation
JP2007512077A (ja) 2003-11-25 2007-05-17 エフ．ディー． カルディオ リミテッド インフレーション・チューブを使用したステントの位置決め
WO2005053555A1 (de) 2003-12-01 2005-06-16 Biotronik Crm Patent Ag Elektrodenleitung für die elektrotherapie von herzgewebe
AU2004294324B2 (en) 2003-12-02 2010-05-27 Fuso Pharmaceutical Industries, Ltd. Dual-chamber container
JP4391221B2 (ja) 2003-12-22 2009-12-24 有限会社日本エレクテル 高周波加温バルーンカテーテル
US20050148842A1 (en) 2003-12-22 2005-07-07 Leming Wang Positioning devices and methods for in vivo wireless imaging capsules
JPWO2005065559A1 (ja) 2004-01-06 2007-12-20 東レ株式会社 バルーンカテーテル
US7326206B2 (en) 2004-01-16 2008-02-05 St. Jude Medical, Atrial Fibrillation Division, Inc. Conforming-electrode catheter and method for ablation
US7371231B2 (en) 2004-02-02 2008-05-13 Boston Scientific Scimed, Inc. System and method for performing ablation using a balloon
KR100605849B1 (ko) 2004-02-09 2006-08-01 삼성전자주식회사 휴대용 단말기의 데이터 저장 및 재생방법
US20050182479A1 (en) 2004-02-13 2005-08-18 Craig Bonsignore Connector members for stents
US7157492B2 (en) 2004-02-26 2007-01-02 Wyeth Dibenzo chromene derivatives and their use as ERβ selective ligands
US20050203410A1 (en) 2004-02-27 2005-09-15 Ep Medsystems, Inc. Methods and systems for ultrasound imaging of the heart from the pericardium
US7662114B2 (en) 2004-03-02 2010-02-16 Focus Surgery, Inc. Ultrasound phased arrays
US7198632B2 (en) 2004-03-02 2007-04-03 Boston Scientific Scimed, Inc. Occlusion balloon catheter with longitudinally expandable balloon
US8052636B2 (en) 2004-03-05 2011-11-08 Hansen Medical, Inc. Robotic catheter system and methods
US7247141B2 (en) 2004-03-08 2007-07-24 Ethicon Endo-Surgery, Inc. Intra-cavitary ultrasound medical system and method
US7238184B2 (en) 2004-03-15 2007-07-03 Boston Scientific Scimed, Inc. Ablation probe with peltier effect thermal control
US20080147002A1 (en) 2004-03-23 2008-06-19 Michael Eric Gertner Obesity treatment systems
US20080300618A1 (en) 2004-03-23 2008-12-04 Michael Eric Gertner Obesity treatment systems
US20060142790A1 (en) 2004-03-23 2006-06-29 Michael Gertner Methods and devices to facilitate connections between body lumens
US20060195139A1 (en) 2004-03-23 2006-08-31 Michael Gertner Extragastric devices and methods for gastroplasty
WO2006049725A2 (en) 2004-03-23 2006-05-11 Minimus Surgical Systems Surgical systems and devices to enhance gastric restriction therapies
US7946976B2 (en) 2004-03-23 2011-05-24 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US7841978B2 (en) 2004-03-23 2010-11-30 Michael Gertner Methods and devices for to treatment of obesity
US20070233170A1 (en) 2004-03-23 2007-10-04 Michael Gertner Extragastric Balloon
US8343031B2 (en) 2004-03-23 2013-01-01 Michael Gertner Obesity treatment systems
US20080071306A1 (en) 2004-03-23 2008-03-20 Michael Gertner Extragastric Balloon With Attachment Tabs
US8001976B2 (en) 2004-03-23 2011-08-23 Michael Gertner Management systems for the surgically treated obese patient
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US20050228415A1 (en) 2004-03-23 2005-10-13 Michael Gertner Methods and devices for percutaneous, non-laparoscopic treatment of obesity
US9555223B2 (en) 2004-03-23 2017-01-31 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
US7854733B2 (en) 2004-03-24 2010-12-21 Biosense Webster, Inc. Phased-array for tissue treatment
US20050214268A1 (en) 2004-03-25 2005-09-29 Cavanagh William A Iii Methods for treating tumors and cancerous tissues
US7323006B2 (en) 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
JP4216810B2 (ja) 2004-03-30 2009-01-28 株式会社東芝 生体情報計測装置
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US20060018949A1 (en) 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US7566319B2 (en) 2004-04-21 2009-07-28 Boston Scientific Scimed, Inc. Traction balloon
US20050245862A1 (en) 2004-04-28 2005-11-03 Endobionics, Inc. Torque mechanism for interventional catheters
US20050251116A1 (en) 2004-05-05 2005-11-10 Minnow Medical, Llc Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter
US7291142B2 (en) 2004-05-10 2007-11-06 Boston Scientific Scimed, Inc. Low temperature lesion formation apparatus, systems and methods
US7087053B2 (en) 2004-05-27 2006-08-08 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter with bifurcated, collapsible tip for sensing and ablating
US7527643B2 (en) 2004-05-28 2009-05-05 Cook Incorporated Exchangeable delivery system for expandable prosthetic devices
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
WO2005120375A2 (en) 2004-06-02 2005-12-22 Medtronic, Inc. Loop ablation apparatus and method
US7640046B2 (en) 2004-06-18 2009-12-29 Cardiac Pacemakers, Inc. Methods and apparatuses for localizing myocardial infarction during catheterization
US7197354B2 (en) 2004-06-21 2007-03-27 Mediguide Ltd. System for determining the position and orientation of a catheter
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US20060024564A1 (en) 2004-07-06 2006-02-02 Manclaw Ronald R Manclaw-Harrison fuel cell
WO2006015354A2 (en) 2004-07-30 2006-02-09 Washington University In St. Louis Electrosurgical systems and methods
US7799021B2 (en) 2004-08-04 2010-09-21 Kimberly-Clark Inc. Electrosurgical treatment in conjunction with monitoring
AP2007003921A0 (en) 2004-08-16 2007-02-28 Atugen Ag Therapeutic uses of inhibitors of rtp801
US7540852B2 (en) 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
JP2008512458A (ja) 2004-09-07 2008-04-24 ワイス ６Ｈ−［１］ベンゾピラノ［４，３−ｂ］キノリン及びエストロゲン様物質としてのそれらの使用
US20060095096A1 (en) 2004-09-09 2006-05-04 Debenedictis Leonard C Interchangeable tips for medical laser treatments and methods for using same
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8545488B2 (en) 2004-09-17 2013-10-01 The Spectranetics Corporation Cardiovascular imaging system
US7458971B2 (en) 2004-09-24 2008-12-02 Boston Scientific Scimed, Inc. RF ablation probe with unibody electrode element
US20060069385A1 (en) 2004-09-28 2006-03-30 Scimed Life Systems, Inc. Methods and apparatus for tissue cryotherapy
US7635383B2 (en) 2004-09-28 2009-12-22 Boston Scientific Scimed, Inc. Rotating stent delivery system for side branch access and protection and method of using same
WO2006042047A1 (en) 2004-10-07 2006-04-20 Flea Street Translational, Llc Methods, systems and devices for establishing communication between hollow organs and tissue lumens
US20060089637A1 (en) 2004-10-14 2006-04-27 Werneth Randell L Ablation catheter
US7887538B2 (en) 2005-10-15 2011-02-15 Baxano, Inc. Methods and apparatus for tissue modification
US7938830B2 (en) 2004-10-15 2011-05-10 Baxano, Inc. Powered tissue modification devices and methods
US7962854B2 (en) 2004-10-19 2011-06-14 Sony Ericsson Mobile Communications Ab Systems, methods and computer program products for displaying content on multiple display screens using handheld wireless communicators
US20060083194A1 (en) 2004-10-19 2006-04-20 Ardian Dhrimaj System and method rendering audio/image data on remote devices
US20060089638A1 (en) 2004-10-27 2006-04-27 Yuval Carmel Radio-frequency device for passivation of vascular plaque and method of using same
US7753907B2 (en) 2004-10-29 2010-07-13 Boston Scientific Scimed, Inc. Medical device systems and methods
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US7200445B1 (en) 2005-10-21 2007-04-03 Asthmatx, Inc. Energy delivery devices and methods
US20090240249A1 (en) 2004-11-08 2009-09-24 Cardima, Inc. System and Method for Performing Ablation and Other Medical Procedures Using An Electrode Array with Flexible Circuit
WO2006055845A1 (en) 2004-11-15 2006-05-26 Cytyc Corporation System for drug delivery
US8617152B2 (en) 2004-11-15 2013-12-31 Medtronic Ablation Frontiers Llc Ablation system with feedback
JP2008520331A (ja) 2004-11-18 2008-06-19 トランスファーマ メディカル リミテッド 薬剤の経皮的送達のためのマイクロチャネル形成とイオントフォレーシスの組合せ
US20060167106A1 (en) 2004-11-19 2006-07-27 Mei Zhang Compounds acting at the centrosome
US7473890B2 (en) 2004-11-23 2009-01-06 New York University Manipulation of objects in potential energy landscapes
US20060247266A1 (en) 2004-11-26 2006-11-02 Asahi Kasei Pharma Corporation Nitrogen-containing tricyclic compounds
US8048144B2 (en) 2004-11-30 2011-11-01 Scimed Life Systems, Inc. Prosthesis fixation device and method
EP1819304B1 (en) 2004-12-09 2023-01-25 Twelve, Inc. Aortic valve repair
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
WO2006066610A1 (en) 2004-12-23 2006-06-29 Telecom Italia S.P.A. Method and system for video telephone communications set up, related equipment and computer program product
US20080009927A1 (en) 2005-01-11 2008-01-10 Vilims Bradley D Combination Electrical Stimulating and Infusion Medical Device and Method
US8007440B2 (en) 2005-02-08 2011-08-30 Volcano Corporation Apparatus and methods for low-cost intravascular ultrasound imaging and for crossing severe vascular occlusions
US7828837B2 (en) 2005-02-17 2010-11-09 Khoury Medical Devices, LLC. Vascular endograft
KR20160120809A (ko) 2005-03-04 2016-10-18 수캄포 아게 말초 혈관 질환 치료를 위한 방법 및 조성물
US8801701B2 (en) 2005-03-09 2014-08-12 Sunnybrook Health Sciences Centre Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment
US7759315B2 (en) 2005-03-09 2010-07-20 Csl Behring Ag Treatment of inflammatory conditions of the intestine
US7674256B2 (en) 2005-03-17 2010-03-09 Boston Scientific Scimed, Inc. Treating internal body tissue
ATE533520T1 (de) 2005-03-23 2011-12-15 Abbott Lab Abgabe von stark lipophilen mitteln durch medizinprodukte
US7670337B2 (en) 2005-03-25 2010-03-02 Boston Scientific Scimed, Inc. Ablation probe having a plurality of arrays of electrodes
US20060224153A1 (en) 2005-04-05 2006-10-05 Fischell Robert E Catheter system for the treatment of atrial fibrillation
US7715912B2 (en) 2005-04-13 2010-05-11 Intelect Medical, Inc. System and method for providing a waveform for stimulating biological tissue
US8298224B2 (en) 2005-04-21 2012-10-30 Asthmatx, Inc. Control methods and devices for energy delivery
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
US20060247760A1 (en) 2005-04-29 2006-11-02 Medtronic Vascular, Inc. Methods and apparatus for treatment of aneurysms adjacent branch arteries
US7505816B2 (en) 2005-04-29 2009-03-17 Medtronic, Inc. Actively cooled external energy source, external charger, system of transcutaneous energy transfer, system of transcutaneous charging and method therefore
US7806871B2 (en) 2005-05-09 2010-10-05 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
AU2006323195A1 (en) 2005-05-10 2007-06-14 Michael Gertner Obesity treatment systems
US7942874B2 (en) 2005-05-12 2011-05-17 Aragon Surgical, Inc. Apparatus for tissue cauterization
US20080091193A1 (en) 2005-05-16 2008-04-17 James Kauphusman Irrigated ablation catheter having magnetic tip for magnetic field control and guidance
WO2006127096A2 (en) 2005-05-20 2006-11-30 Omeros Corporation Cyclooxygenase inhibitor and calcium channel antagonist compositions and methods for use in urological procedures
US10092429B2 (en) 2005-08-22 2018-10-09 Incept, Llc Flared stents and apparatus and methods for delivering them
US7767844B2 (en) 2005-05-23 2010-08-03 Atomic Energy Council Method for manufacturing diethylene triamine pentaacetic acid derivative
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US7584004B2 (en) 2005-06-13 2009-09-01 Cardiac Pacemakers, Inc. Vascularly stabilized peripheral nerve cuff assembly
EP1895927A4 (en) * 2005-06-20 2011-03-09 Medtronic Ablation Frontiers ABLATION CATHETER
US7717853B2 (en) 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
AU2006263448B2 (en) 2005-06-29 2013-01-24 Radiant Medical, Inc. Devices, systems and methods for rapid endovascular cooling
US20070016274A1 (en) 2005-06-29 2007-01-18 Boveja Birinder R Gastrointestinal (GI) ablation for GI tumors or to provide therapy for obesity, motility disorders, G.E.R.D., or to induce weight loss
WO2007005386A1 (en) 2005-06-30 2007-01-11 Rox Medical, Inc. Devices, systems, and methods for creation of a peripherally located fistula
DE102005032755B4 (de) 2005-07-13 2014-09-04 Siemens Aktiengesellschaft System zur Durchführung und Überwachung minimal-invasiver Eingriffe
US20070016184A1 (en) 2005-07-14 2007-01-18 Ethicon Endo-Surgery, Inc. Medical-treatment electrode assembly and method for medical treatment
EP1906853B1 (en) 2005-07-21 2017-09-06 Covidien LP Systems for treating a hollow anatomical structure
WO2007013065A2 (en) 2005-07-25 2007-02-01 Rainbow Medical Ltd. Electrical stimulation of blood vessels
AU2006272544B2 (en) 2005-07-26 2012-01-19 Rox Medical, Inc. Devices, systems, and methods for peripheral arteriovenous fistula creation
WO2007021804A2 (en) 2005-08-12 2007-02-22 Proteus Biomedical, Inc. Evaluation of depolarization wave conduction velocity
US7591996B2 (en) 2005-08-17 2009-09-22 University Of Washington Ultrasound target vessel occlusion using microbubbles
DE102005041601B4 (de) 2005-09-01 2010-07-08 Siemens Ag Ablationskatheter zum Setzen einer Läsion und Verfahren zur Herstellung eines Ablationskatheters
WO2007028258A2 (en) 2005-09-09 2007-03-15 Ottawa Health Research Institute Interpenetrating networks, and related methods and compositions
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US20070073151A1 (en) 2005-09-13 2007-03-29 General Electric Company Automated imaging and therapy system
WO2007041593A2 (en) 2005-10-03 2007-04-12 Combinatorx, Incorporated Anti-scarring drug combinations and use thereof
US20070299043A1 (en) 2005-10-03 2007-12-27 Hunter William L Anti-scarring drug combinations and use thereof
DE102005050344A1 (de) 2005-10-20 2007-05-03 Siemens Ag Kryokatheter zur Einführung in ein Körpergefäß sowie medizinische Untersuchungs- und Behandlungsvorrichtung
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
EP1946712B1 (en) 2005-11-01 2012-08-29 Japan Electel Inc. Balloon catheter system
US8052700B2 (en) 2005-11-02 2011-11-08 University Of Massachusetts Tissue clamp
US7901420B2 (en) 2005-11-02 2011-03-08 University Of Massachusetts Tissue clamp
US10716749B2 (en) 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
WO2007055521A1 (en) 2005-11-09 2007-05-18 Korea University Industrial & Academic Collaboration Foundation Radio frequency ablation electrode for selected tissue removal
US7766833B2 (en) 2005-11-23 2010-08-03 General Electric Company Ablation array having independently activated ablation elements
US7959627B2 (en) 2005-11-23 2011-06-14 Barrx Medical, Inc. Precision ablating device
US8190238B2 (en) 2005-12-09 2012-05-29 Hansen Medical, Inc. Robotic catheter system and methods
US7776967B2 (en) 2005-12-16 2010-08-17 Continental Ag Polyorganosiloxane composition for use in unsaturated elastomer, article made therefrom, and associated method
US20080108867A1 (en) 2005-12-22 2008-05-08 Gan Zhou Devices and Methods for Ultrasonic Imaging and Ablation
US8031927B2 (en) 2005-12-28 2011-10-04 The General Hospital Corporation Medical image processing
US7896874B2 (en) 2005-12-29 2011-03-01 Boston Scientific Scimed, Inc. RF ablation probes with tine valves
US7993334B2 (en) 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US20070162109A1 (en) 2006-01-11 2007-07-12 Luis Davila Intraluminal stent graft
US8033284B2 (en) 2006-01-11 2011-10-11 Curaelase, Inc. Therapeutic laser treatment
CA2574935A1 (en) 2006-01-24 2007-07-24 Sherwood Services Ag A method and system for controlling an output of a radio-frequency medical generator having an impedance based control algorithm
CA2641117C (en) 2006-01-31 2018-01-02 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US20070179496A1 (en) 2006-01-31 2007-08-02 Medtronic, Inc. Flexible catheter for ablation therapy
WO2007092330A1 (en) 2006-02-03 2007-08-16 Synecor, Llc Intravascular device for neuromodulation
US7918850B2 (en) 2006-02-17 2011-04-05 Biosense Wabster, Inc. Lesion assessment by pacing
US7869854B2 (en) 2006-02-23 2011-01-11 Magnetecs, Inc. Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation
US20070208210A1 (en) 2006-03-02 2007-09-06 G&L Consulting, Llc Method and apparatus to unload a failing heart
US20070208256A1 (en) 2006-03-03 2007-09-06 Medtronic Vascular, Inc. Multiple Branch Tubular Prosthesis and Methods
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US8027718B2 (en) 2006-03-07 2011-09-27 Mayo Foundation For Medical Education And Research Regional anesthetic
US7894905B2 (en) 2006-03-13 2011-02-22 Neuropace, Inc. Implantable system enabling responsive therapy for pain
US20070219576A1 (en) 2006-03-16 2007-09-20 Medtronic Vascular, Inc. Reversibly and Radially Expandable Electroactive Polymer Element for Temporary Occlusion of a Vessel
WO2007109171A2 (en) 2006-03-17 2007-09-27 Microcube, Llc Devices and methods for creating continuous lesions
US20070225781A1 (en) 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
EP2010085A1 (en) 2006-03-31 2009-01-07 Breval S.R.L. Device and method for the thermal ablation of tumors by means of high-frequency electromagnetic energy under overpressure conditions
US20080004673A1 (en) 2006-04-03 2008-01-03 Cvrx, Inc. Implantable extravascular electrostimulation system having a resilient cuff
JP5209603B2 (ja) 2006-04-13 2013-06-12 ミラビリス メディカ インコーポレイテッド 高密度焦点式超音波エネルギーの使用による機能性子宮出血、子宮内膜の病状、および子宮頸部の新形成の治療のための方法および装置
EP2010088A1 (en) 2006-04-14 2009-01-07 Koninklijke Philips Electronics N.V. Systems and methods for cardiac ablation using laser induced optical breakdown (liob)
US20080051454A1 (en) 2006-04-21 2008-02-28 The Board Of Trustees Operating Michigan State University Compositions and methods for transient receptor potential vanilloid (TRPV) channel mediated treatments
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US7511494B2 (en) 2006-05-11 2009-03-31 The General Hospital Corporation Method for measuring the microarchitecture of complex tissue with MRI
EP3756604A1 (en) 2006-05-12 2020-12-30 Vytronus, Inc. Device for ablating body tissue
US7725157B2 (en) 2006-05-16 2010-05-25 General Electric Company System and method for interventional procedures using MRI
EP2032045A2 (en) 2006-05-24 2009-03-11 Emcision Limited Vessel sealing device and methods
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
CA2653864A1 (en) 2006-06-02 2007-12-13 Victhom Human Bionics Inc. Nerve cuff, method and apparatus for manufacturing same
WO2007141796A2 (en) 2006-06-09 2007-12-13 Quark Pharmaceuticals, Inc. Therapeutic uses of inhibitors of rtp801l
US20080097251A1 (en) 2006-06-15 2008-04-24 Eilaz Babaev Method and apparatus for treating vascular obstructions
EP2465574B1 (en) 2006-06-28 2015-10-28 Ardian, Inc. Systems for thermally-induced renal neuromodulation
JP2008010537A (ja) 2006-06-28 2008-01-17 Toshiba Corp Ｎａｎｄ型不揮発性半導体記憶装置およびｎａｎｄ型不揮発性半導体記憶装置の製造方法
CA2552620C (en) 2006-07-20 2014-07-15 Ruggedcom Inc. An anchoring member to facilitate fastening daughter boards to a mother board and a method for use
GB0614557D0 (en) 2006-07-21 2006-08-30 Emcision Ltd Tissue Ablator
US8452988B2 (en) 2006-07-24 2013-05-28 Michael Sujue Wang Secure data storage for protecting digital content
KR101794531B1 (ko) 2006-07-28 2017-11-07 메르츠 노스 아메리카 인코포레이티드 신경 전도를 제한하기 위한 절제 장치 및 시스템
US8409172B2 (en) 2006-08-03 2013-04-02 Hansen Medical, Inc. Systems and methods for performing minimally invasive procedures
US20080039727A1 (en) 2006-08-08 2008-02-14 Eilaz Babaev Ablative Cardiac Catheter System
US20090221955A1 (en) 2006-08-08 2009-09-03 Bacoustics, Llc Ablative ultrasonic-cryogenic methods
US8725225B2 (en) 2006-08-10 2014-05-13 University Of Rochester Intraoperative imaging of renal cortical tumors and cysts
WO2008022148A2 (en) 2006-08-14 2008-02-21 Stereotaxis, Inc. Method and apparatus for ablative recanalization of blocked vasculature
US20080243091A1 (en) 2006-08-22 2008-10-02 Mitchell R. Humphreys Process and System For Systematic Oxygenation and Renal Preservation During Retrograde Perfusion of the Ischemic Kidney
KR20090045940A (ko) 2006-08-29 2009-05-08 포휴먼텍(주) 세포자멸사의 억제를 위한 약학 조성물, 및 이를 전달하는 방법
US20080064957A1 (en) 2006-09-07 2008-03-13 Spence Paul A Ultrasonic implant, systems and methods related to diverting material in blood flow away from the head
US20080082109A1 (en) 2006-09-08 2008-04-03 Hansen Medical, Inc. Robotic surgical system with forward-oriented field of view guide instrument navigation
WO2008033867A2 (en) 2006-09-11 2008-03-20 Enbio Limited Method of doping surfaces
US20080071269A1 (en) 2006-09-18 2008-03-20 Cytyc Corporation Curved Endoscopic Medical Device
US8486060B2 (en) 2006-09-18 2013-07-16 Cytyc Corporation Power ramping during RF ablation
US7691080B2 (en) 2006-09-21 2010-04-06 Mercator Medsystems, Inc. Dual modulus balloon for interventional procedures
WO2008111960A2 (en) 2006-09-29 2008-09-18 University Of Akron Metal oxide fibers and nanofibers, method for making same, and uses thereof
US8617149B2 (en) 2006-10-02 2013-12-31 Boston Scientific Scimed, Inc. Common bond, double-balloon catheter
US8641660B2 (en) 2006-10-04 2014-02-04 P Tech, Llc Methods and devices for controlling biologic microenvironments
US7664548B2 (en) 2006-10-06 2010-02-16 Cardiac Pacemakers, Inc. Distributed neuromodulation system for treatment of cardiovascular disease
EP2076194B1 (en) 2006-10-18 2013-04-24 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
EP2992850A1 (en) 2006-10-18 2016-03-09 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
US7615072B2 (en) 2006-11-14 2009-11-10 Medtronic Vascular, Inc. Endoluminal prosthesis
US20080255550A1 (en) 2006-11-30 2008-10-16 Minos Medical Systems and methods for less invasive neutralization by ablation of tissue including the appendix and gall bladder
US20080140002A1 (en) 2006-12-06 2008-06-12 Kamal Ramzipoor System for delivery of biologically active substances with actuating three dimensional surface
US7699809B2 (en) 2006-12-14 2010-04-20 Urmey William F Catheter positioning system
US7846160B2 (en) 2006-12-21 2010-12-07 Cytyc Corporation Method and apparatus for sterilization
US20080208162A1 (en) 2007-02-26 2008-08-28 Joshi Ashok V Device and Method For Thermophoretic Fluid Delivery
US20080221448A1 (en) 2007-03-07 2008-09-11 Khuri-Yakub Butrus T Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions
US8406877B2 (en) 2007-03-19 2013-03-26 Cardiac Pacemakers, Inc. Selective nerve stimulation with optionally closed-loop capabilities
JP5301527B2 (ja) 2007-03-30 2013-09-25 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 放射線治療及び他の治療を誘導するためのｍｒｉガイド下ｈｉｆｕマーキング
US8198611B2 (en) 2007-04-02 2012-06-12 Globalfoundries Inc. Laser beam formatting module and method for fabricating semiconductor dies using same
US9259233B2 (en) 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US7495439B2 (en) 2007-04-27 2009-02-24 The General Hospital Corporation MRI method for reducing artifacts using RF pulse at offset frequency
US8641704B2 (en) 2007-05-11 2014-02-04 Medtronic Ablation Frontiers Llc Ablation therapy system and method for treating continuous atrial fibrillation
US11395694B2 (en) 2009-05-07 2022-07-26 St. Jude Medical, Llc Irrigated ablation catheter with multiple segmented ablation electrodes
CA2687876A1 (en) 2007-05-23 2009-03-05 Oscillon Ltd. Apparatus and method for guided chronic total occlusion penetration
US20080312673A1 (en) 2007-06-05 2008-12-18 Viswanathan Raju R Method and apparatus for CTO crossing
US8263104B2 (en) 2007-06-08 2012-09-11 Northwestern University Polymer nanofilm coatings
US20090210953A1 (en) 2007-06-08 2009-08-20 Bryan Moyer Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release
US20080312644A1 (en) 2007-06-14 2008-12-18 Boston Scientific Scimed, Inc. Cryogenic balloon ablation instruments and systems
US20090270850A1 (en) 2007-06-20 2009-10-29 Tea Time Partners, L.P., Organized In Texas Devices and methods for the ablation of tissue in the lateral direction
US20090018486A1 (en) 2007-07-13 2009-01-15 Menachem Goren Diagnosis and treatment of vericocele and prostate disorders
US8828068B2 (en) 2007-07-17 2014-09-09 Cardiac Pacemakers, Inc. Systems and methods for local vasoactive response using temperature modulation
US8702609B2 (en) 2007-07-27 2014-04-22 Meridian Cardiovascular Systems, Inc. Image-guided intravascular therapy catheters
US8821477B2 (en) 2007-08-06 2014-09-02 Boston Scientific Scimed, Inc. Alternative micromachined structures
US8066731B2 (en) 2007-08-20 2011-11-29 Olympus Medical Systems Corp. Treatment device
KR101282285B1 (ko) 2007-08-20 2013-07-10 삼성전자주식회사 이동 통신 시스템에서 위치 기반 서비스 제공 시스템 및방법
US7863897B2 (en) 2007-09-07 2011-01-04 The General Hospital Corporation Method and apparatus for characterizing the temporal resolution of an imaging device
US20090069671A1 (en) 2007-09-10 2009-03-12 General Electric Company Electric Motor Tracking System and Method
US7777486B2 (en) 2007-09-13 2010-08-17 The Board Of Trustees Of The Leland Stanford Junior University Magnetic resonance imaging with bipolar multi-echo sequences
US20090076502A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc. Prostate cancer ablation
US9283034B2 (en) 2007-09-26 2016-03-15 Retrovascular, Inc. Recanalization system using radiofrequency energy
JP5479672B2 (ja) 2007-09-27 2014-04-23 シスメックス株式会社 血液または尿の分析装置およびデータ処理装置
WO2009046441A1 (en) 2007-10-05 2009-04-09 Coaptus Medical Corporation Systems and methods for transeptal cardiac procedures
US20090157161A1 (en) 2007-10-24 2009-06-18 Edwards Lifesciences Corporation Percutaneous Nitinol Stent Extraction Device
WO2009055542A1 (en) 2007-10-26 2009-04-30 University Of Utah Research Foundation Use of mri contrast agents for evaluating the treatment of tumors
US20090112202A1 (en) 2007-10-31 2009-04-30 Boston Scientific Scimed, Inc. Dispersive electrode with thermochromatic properties
US20090118620A1 (en) 2007-11-06 2009-05-07 General Electric Company System and method for tracking an ultrasound catheter
US8613721B2 (en) 2007-11-14 2013-12-24 Medrad, Inc. Delivery and administration of compositions using interventional catheters
US20090131798A1 (en) 2007-11-19 2009-05-21 Minar Christopher D Method and apparatus for intravascular imaging and occlusion crossing
US20090143640A1 (en) 2007-11-26 2009-06-04 Voyage Medical, Inc. Combination imaging and treatment assemblies
WO2009068689A2 (en) 2007-11-30 2009-06-04 Novartis Ag Combination of protein tyrosine phosphatase inhibitors and human growth hormone for the treatment of muscle atrophy and related disorders
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090171333A1 (en) 2007-12-27 2009-07-02 Boston Scientific Scimed, Inc. System and method for controllably delivering liquid coolant to a cryo-ablation device
US8021413B2 (en) 2007-12-27 2011-09-20 Cook Medical Technologies Llc Low profile medical device
US8366615B2 (en) 2009-01-05 2013-02-05 Texas Heart Institute Introducer sheath with electrodes
US8273023B2 (en) 2009-01-05 2012-09-25 Texas Heart Institute Introducer sheathe with electrodes
GB2456301A (en) 2008-01-08 2009-07-15 Gmj Design Ltd Surface Representation from a Point Cloud
US8676322B2 (en) 2008-01-30 2014-03-18 Boston Scientific Neuromodulation Corporation Methods and systems of treating pancreatitis pain
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US8738147B2 (en) 2008-02-07 2014-05-27 Cardiac Pacemakers, Inc. Wireless tissue electrostimulation
WO2009105482A1 (en) 2008-02-19 2009-08-27 Boston Scientific Scimed, Inc. Apparatus for uniformly distributing coolant within a cryo-ablation device
US20110040324A1 (en) 2008-03-17 2011-02-17 Mccarthy Patrick M Devices and methods for percutaneous access, hemostasis, and closure
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US20090247966A1 (en) 2008-03-28 2009-10-01 Gunn Euen T Methods and products for applying structured compositions to a substrate
US20090253974A1 (en) 2008-04-08 2009-10-08 Marc Mounir Rahme Use of tools, mapping systems, catheters, electrodes or any devices targeting any autonomic nerve(s) structure(s) in the human heart for the diagnostic, treatment and/or prevention of the recurrence of cardiac arrhythmias.
US20090264755A1 (en) 2008-04-22 2009-10-22 National Taiwan University High-Intensity Ultrasonic Vessel Ablator Using Blood Flow Signal for Precise Positioning
US7956613B2 (en) 2008-05-02 2011-06-07 The General Hospital Corporation Method for imaging acoustically induced rotary saturation with a magnetic resonance imaging system
WO2009137819A1 (en) 2008-05-09 2009-11-12 Innovative Pulmonary Solutions, Inc. Systems, assemblies, and methods for treating a bronchial tree
JP2011521679A (ja) 2008-05-12 2011-07-28 ボストン サイエンティフィック サイムド，インコーポレイテッド 冷凍アブレーションの冷却材を冷却する装置
US8480663B2 (en) 2008-05-15 2013-07-09 Boston Scientific Scimed, Inc. Apparatus and methods for cryogenically ablating tissue and adjusting cryogenic ablation regions
US8128617B2 (en) 2008-05-27 2012-03-06 Boston Scientific Scimed, Inc. Electrical mapping and cryo ablating with a balloon catheter
US8187261B2 (en) 2008-05-29 2012-05-29 Boston Scientific Scimed, Inc. Regulating internal pressure of a cryotherapy balloon catheter
US20090318749A1 (en) 2008-06-19 2009-12-24 Craig Stolen Method and apparatus for pacing and intermittent ischemia
US20100049099A1 (en) 2008-07-18 2010-02-25 Vytronus, Inc. Method and system for positioning an energy source
US20100030061A1 (en) 2008-07-31 2010-02-04 Canfield Monte R Navigation system for cardiac therapies using gating
US9211155B2 (en) 2008-08-20 2015-12-15 Prostacare Pty Ltd. Non-thermal ablation system for treating BPH and other growths
WO2010022314A1 (en) 2008-08-21 2010-02-25 Med-El Elektromedizinische Geraete Gmbh Multipath stimulation hearing systems
WO2010022367A2 (en) 2008-08-21 2010-02-25 Bliss Holdings, Llc Illumination-based medical device and methods of use thereof
US20100069837A1 (en) 2008-09-16 2010-03-18 Boston Scientific Scimed, Inc. Balloon Assembly and Method for Therapeutic Agent Delivery
EP2341839B1 (en) 2008-09-22 2015-10-21 Vessix Vascular, Inc. System for vascular ultrasound treatments
DE102008048616B4 (de) 2008-09-23 2010-08-05 Olympus Winter & Ibe Gmbh Urologischer Ballonkatheter
DE102008050347B4 (de) 2008-10-02 2011-01-20 Siemens Aktiengesellschaft Verfahren, Magnetresonanzanlage und Datenträger zur Bestimmung eines Nierenfunktionsparameters
EP2349440B1 (en) 2008-10-07 2019-08-21 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US8372068B2 (en) 2008-10-21 2013-02-12 Hermes Innovations, LLC Tissue ablation systems
US20100114244A1 (en) 2008-10-31 2010-05-06 Medtronic, Inc. Electrical renal autonomic blockade
WO2010056771A1 (en) 2008-11-11 2010-05-20 Shifamed Llc Low profile electrode assembly
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
CA2743992A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
CN102307618B (zh) 2008-12-09 2014-03-12 内费拉有限公司 泌尿系统的刺激
WO2010082993A2 (en) 2008-12-11 2010-07-22 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US20100160903A1 (en) 2008-12-22 2010-06-24 Yosef Krespi Process and system for treating a vascular occlusion or other endoluminal structure
US20100160906A1 (en) 2008-12-23 2010-06-24 Asthmatx, Inc. Expandable energy delivery devices having flexible conductive elements and associated systems and methods
US8317810B2 (en) 2008-12-29 2012-11-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Tissue puncture assemblies and methods for puncturing tissue
US9352174B2 (en) 2008-12-30 2016-05-31 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation system with blood leakage minimization and tissue protective capabilities
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
EP2208506A1 (en) 2009-01-16 2010-07-21 Oncotherm Kft. Intraluminar oncothermia catheter
WO2010088301A1 (en) 2009-01-27 2010-08-05 Boveda Marco Medical Llc Catheters and methods for performing electrophysiological interventions
EP2404171A4 (en) 2009-03-03 2016-01-27 Mc10 Inc SYSTEMS, METHODS AND DEVICES HAVING INTEGRATED INTEGRATED CIRCUIT ELEMENTS FOR DETECTING AND ADMINISTERING THERAPY
US20100249604A1 (en) 2009-03-31 2010-09-30 Boston Scientific Corporation Systems and methods for making and using a motor distally-positioned within a catheter of an intravascular ultrasound imaging system
US8287532B2 (en) 2009-04-13 2012-10-16 Biosense Webster, Inc. Epicardial mapping and ablation catheter
EP2421536B1 (en) 2009-04-20 2015-08-26 Gilead Calistoga LLC Methods of treatment for solid tumors
US8399443B2 (en) 2009-04-22 2013-03-19 Mercator Medsystems, Inc. Treatment of hypertension by renal vascular delivery of guanethidine
US8517955B2 (en) 2009-05-08 2013-08-27 Broncus Medical Inc. Tissue sampling devices, systems and methods
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US8292881B2 (en) 2009-05-27 2012-10-23 Vivant Medical, Inc. Narrow gauge high strength choked wet tip microwave ablation antenna
ES2717268T3 (es) 2009-07-08 2019-06-20 Sanuwave Inc Uso de ondas de choque de presión intracorpóreas en medicina
WO2011005901A2 (en) 2009-07-09 2011-01-13 Silhouette Medical Inc. Apparatus for treating medical conditions of hollow anatomical structures
US20110071400A1 (en) 2009-09-23 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using intravascular ultrasound imaging systems with sealed imaging cores
US20110071401A1 (en) 2009-09-24 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using a stepper motor for an intravascular ultrasound imaging system
US8343145B2 (en) 2009-09-28 2013-01-01 Vivant Medical, Inc. Microwave surface ablation using conical probe
US9101733B2 (en) 2009-09-29 2015-08-11 Biosense Webster, Inc. Catheter with biased planar deflection
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
EP3132828B1 (en) 2009-10-30 2017-10-11 ReCor Medical, Inc. Apparatus for treatment of hypertension through percutaneous ultrasound renal denervation
CN102596319B (zh) 2009-10-30 2015-07-15 科纳医药股份有限公司 通过去肾交感神经非侵入性地治疗高血压的装置
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
EP2498706B1 (en) 2009-11-13 2016-04-20 St. Jude Medical, Inc. Assembly of staggered ablation elements
US20110137155A1 (en) 2009-12-09 2011-06-09 Boston Scientific Scimed, Inc. Delivery device for localized delivery of a therapeutic agent
US9179827B2 (en) 2009-12-15 2015-11-10 Boston Scientific Scimed, Inc. Systems and methods for determining the position and orientation of medical devices inserted into a patient
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
US20110270238A1 (en) 2009-12-31 2011-11-03 Raed Rizq Compliant Cryoballoon Apparatus for Denervating Ostia of the Renal Arteries
US20110264116A1 (en) 2009-12-31 2011-10-27 Gordon Kocur Compressive Denervation Apparatus for Innervated Renal Vasculature
US20110200171A1 (en) 2010-01-19 2011-08-18 Ardian, Inc. Methods and apparatus for renal neuromodulation via stereotactic radiotherapy
CA2793737A1 (en) 2010-03-24 2011-09-29 Shifamed Holdings, Llc Intravascular tissue disruption
CN103068330B (zh) 2010-04-09 2016-06-29 Vessix血管股份有限公司 用于治疗组织的功率发生和控制装置
EP2558016A2 (en) * 2010-04-14 2013-02-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
US20110257641A1 (en) 2010-04-14 2011-10-20 Roger Hastings Phototherapy for renal denervation
US9192790B2 (en) * 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US20110257642A1 (en) 2010-04-16 2011-10-20 Griggs Iii Charles Sherman Method for producing a permanent or nearly permanent skin image, design or tattoo by freezing the skin
JP5977735B2 (ja) 2010-04-26 2016-08-24 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 腎神経調節のためのカテーテル装置
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US8120518B2 (en) 2010-06-14 2012-02-21 Koren Advanced Institute of Science and Technology Digital feedforward sigma-delta modulator in analog-to-digital converter and modulation method thereof
US9358020B2 (en) 2010-06-25 2016-06-07 Boston Scientific Scimed Inc. Catheter device for delivery energy to a vein
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US20120029512A1 (en) 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US20120029496A1 (en) 2010-07-30 2012-02-02 Scott Smith Renal nerve ablation using mild freezing and microwave energy
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US20120029505A1 (en) 2010-07-30 2012-02-02 Jenson Mark L Self-Leveling Electrode Sets for Renal Nerve Ablation
CN103547229B (zh) 2010-08-05 2017-09-26 美敦力Af卢森堡有限责任公司 用于肾神经调制的低温消融装置、系统及方法
CN103200893A (zh) 2010-09-07 2013-07-10 波士顿科学西美德公司 用于肾去神经的自供电消融导管
US20120059241A1 (en) 2010-09-08 2012-03-08 Boston Scientific Scimed, Inc. Systems and methods for making and using a steerable imaging system configured and arranged for insertion into a patient
US20120065554A1 (en) 2010-09-09 2012-03-15 Michael Pikus Dual Balloon Ablation Catheter with Vessel Deformation Arrangement for Renal Nerve Ablation
US20120065506A1 (en) 2010-09-10 2012-03-15 Scott Smith Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation
WO2012054762A2 (en) 2010-10-20 2012-04-26 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable mesh structures for renal neuromodulation and associated systems and methods
US9084610B2 (en) 2010-10-21 2015-07-21 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
JP6046041B2 (ja) 2010-10-25 2016-12-14 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 神経変調療法の評価及びフィードバックのためのデバイス、システム、及び方法
TW201221174A (en) 2010-10-25 2012-06-01 Medtronic Ardian Luxembourg Microwave catheter apparatuses, systems, and methods for renal neuromodulation
EP3100696B1 (en) 2010-10-25 2023-01-11 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses having multi-electrode arrays for renal neuromodulation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9060755B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US20120109021A1 (en) 2010-10-27 2012-05-03 Roger Hastings Renal denervation catheter employing acoustic wave generator arrangement
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US20120123261A1 (en) 2010-11-16 2012-05-17 Jenson Mark L Renal Nerve Ablation Using Mild Freezing and Vibration
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US20120265198A1 (en) 2010-11-19 2012-10-18 Crow Loren M Renal nerve detection and ablation apparatus and method
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120136349A1 (en) 2010-11-30 2012-05-31 Roger Hastings RENAL DENERVATION CATHETER AND METHOD USING pH ALTERATION
US20120157992A1 (en) 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US20120232409A1 (en) 2010-12-15 2012-09-13 Stahmann Jeffrey E System and method for renal artery occlusion during renal denervation therapy
US20120184952A1 (en) 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
CN103813745B (zh) 2011-07-20 2016-06-29 波士顿科学西美德公司 用以可视化、对准和消融神经的经皮装置及方法
CN103813829B (zh) 2011-07-22 2016-05-18 波士顿科学西美德公司 具有可定位于螺旋引导件中的神经调制元件的神经调制系统
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
US20140243821A1 (en) 2011-09-30 2014-08-28 Covidien Lp Energy delivery device and methods of use
WO2013055826A1 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
WO2013055685A2 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
AU2012321166A1 (en) 2011-10-11 2014-05-08 Boston Scientific Scimed, Inc. Ablation catheter with insulated tip
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US20130090650A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Renal nerve ablation cooling device and technique
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
US20130096550A1 (en) 2011-10-18 2013-04-18 Boston Scientific Scimed, Inc. Ablative catheter with electrode cooling and related methods of use
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US20130110106A1 (en) 2011-10-28 2013-05-02 Boston Scientific Scimed, Inc. Expandable structure for off-wall ablation electrode
CN108095821B (zh) 2011-11-08 2021-05-25 波士顿科学西美德公司 孔部肾神经消融
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP2793724B1 (en) 2011-12-23 2016-10-12 Vessix Vascular, Inc. Apparatuses for remodeling tissue of or adjacent to a body passage
CN104135958B (zh) 2011-12-28 2017-05-03 波士顿科学西美德公司 用有聚合物消融元件的新消融导管调变神经的装置和方法
WO2013101446A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Balloon expandable multi-electrode rf ablation catheter
US20130172879A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation medical devices
US20130172880A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for renal nerve modulation
CN104135959A (zh) 2011-12-29 2014-11-05 波士顿科学西美德公司 用于肾神经调变监测的装置和方法
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772590A (en) * 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US6165172A (en) * 1997-09-11 2000-12-26 Vnus Medical Technologies, Inc. Expandable vein ligator catheter and method of use
CN101511292A (zh) * 2005-03-28 2009-08-19 明诺医学有限公司 用于选择性地治疗动脉粥样硬化和其他目标组织的内腔电组织表征和调谐射频能量

Also Published As

Publication number Publication date
AU2011282933A1 (en) 2013-02-21
US10531913B2 (en) 2020-01-14
US9408661B2 (en) 2016-08-09
US20120029510A1 (en) 2012-02-02
JP5953302B2 (ja) 2016-07-20
EP2598069A1 (en) 2013-06-05
JP2013532552A (ja) 2013-08-19
CA2806728A1 (en) 2012-02-02
WO2012015722A1 (en) 2012-02-02
US20160317222A1 (en) 2016-11-03
CN103118619A (zh) 2013-05-22

Similar Documents

Publication Publication Date Title
CN103118619B (zh) 用于肾神经消融的多个柔性线丝上的rf电极
EP2645955B1 (en) Expandable angular vascular electrode for renal nerve ablation
US9649156B2 (en) Bipolar off-wall electrode device for renal nerve ablation
JP5933547B2 (ja) 腎神経切除用の順次始動ｒｆ電極セットを含む装置
CN102933169B (zh) 采用螺旋成形装置的肾动脉去神经支配术器械
US9848946B2 (en) Self-expanding cooling electrode for renal nerve ablation
CN103327921B (zh) 肾神经检测以及消融装置
US9192435B2 (en) Renal denervation catheter with cooled RF electrode
US8974451B2 (en) Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) RF renal denervation catheter with multiple independent electrodes
US20120157992A1 (en) Off-wall electrode device for renal nerve ablation
US20120184952A1 (en) Low-profile off-wall electrode device for renal nerve ablation
US20120029505A1 (en) Self-Leveling Electrode Sets for Renal Nerve Ablation
US20110270238A1 (en) Compliant Cryoballoon Apparatus for Denervating Ostia of the Renal Arteries
JP2013532564A (ja) 腎神経アブレーションのための表面電極および一体的冷却を備えたバルーン

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160907

Termination date: 20190729