CN103006354A

CN103006354A - Artificial acetabulum acetabular cup with gradient structure and preparation method thereof

Info

Publication number: CN103006354A
Application number: CN2012104966407A
Authority: CN
Inventors: 宾月珍; 侯代水; 时晓梅
Original assignee: Dalian University of Technology
Current assignee: Dalian University of Technology
Priority date: 2012-11-29
Filing date: 2012-11-29
Publication date: 2013-04-03

Abstract

The invention discloses an artificial acetabulum acetabular cup with a gradient structure, which can effectively restrain the osteolysis process and prolong the service life of the artificial acetabulum acetabular cup. The artificial acetabulum acetabular cup is characterized in that the artificial acetabulum acetabular cup consists of a plurality of layers of cap-shaped joint bodies from inside to outside; each single layer structure is formed by the preparation of a ultra-high molecular weight polyethylene/hydroxyapatite composite material; and the content of hydroxyapatite on all single layers from inside to outside is gradually reduced. As the artificial acetabulum acetabular cup prepared by the invention has the gradient structure similar to that of a human skeleton, and the hydroxyapatite with the biological activity is added in the material, the osteolysis and the prosthesis failure can be effectively reduced, so that the service lives of artificial joints are greatly prolonged.

Description

A kind of gradient-structure manual acetabulum mortar cup and preparation method thereof

Technical field

The present invention relates to a kind of novel artificial hip cotyle cup, be used for prolonging the acetabular bone mortar cup service life of existing artificial hip joint replacing, and reduce the complication that causes because of the wearing and tearing of material etc.

Background technology

The of paramount importance biomaterial ingredient of artificial joint material, especially recent two decades has obtained significant progress in the last hundred years.Artificial joint comprises the joints such as hip, knee joint, shoulder, wrist, ankle, in recent years.Prosthetic replacement's quantity increases year by year, mainly take knee joint, hip replacement as main.The annual total hip replacement in the whole world just has examples up to a million.The hip replacement surgery of carrying out every year in the U.S. is no less than 200,000 examples, simultaneously civil affairs department's report shows, China only not free user of limbs just approximately has 1,500 ten thousand, wherein disabled approximately 7,800,000, and along with the development of society, science and technology and medical science, the demand of artificial joint will be increasing.

Ultra High Molecular Weight Polyethylene Composites is the hip cotyle cup material that adopts at present extensively, and the coefficient of friction of it and metal hip joint head is near the coefficient of friction of human hip, and it is the most extensive that it joins the assistant formula formula.Pure ultra-high molecular mass polyethylene hip cotyle cup generally is through hot-forming or be prepared from through lathe grinding by bar, it has good biocompatibility, chemical stability, impact resistance, wearability and rotproofness, is a kind of desirable macromolecular material.But since by the artificial hip joint mortar cup of pure ultra-high molecular mass polyethylene preparation in the prolonged application process, ultra-high molecular weight polyethylene gathers because of oxidized, wearing and tearing and abrasive dust, easily cause osteolysis and then cause aseptic becoming flexible, thus the service life of having increased the weight of the painful of user and having reduced artificial hip joint.Therefore, people are actively making great efforts to explore and how to improve ultrahigh molecular weight polyethylene abrasion-proof and how to reduce because of osteolysis that artificial hip joint mortar cup wearing and tearing cause, reach and prolong the effective ways that artificial closes the purpose in service life.

Hydroxyapatite forms identical with the inorganic substances of human body hard tissue (bone and tooth), can be directly behind the implant into body and the bone formation synostosis, and interface bond strength meets or exceeds the intensity of bone and implant self between the bone, be that hydroxyapatite has preferably biological activity, but because the crystal fragility of pure ha is large, rupture strength is low, is not suitable for use in carrying larger hard tissue repair and substitution material.

The utility model patent of Liu Qibin (CN 101053675A) proposes a kind of gradient biologically active ceramic coating material of a kind of titanium valve by the different quality mark and composite ceramic preparation, this utility model patent is with even with the titanium valve mixed grinding again behind ceramics and the rare earth oxide mix homogeneously, obtain the coated powder material, with the coated powder material for preparing be pressed in advance titanium alloy surface after binding agent mixes, adopt at last broadband laser cladding technique in titanium alloy surface cladding the first terraced coating, the preparation second that uses the same method is adopted in the cleaning surface then, three terraced coatings are to obtain making gradient biologically active ceramic on the titanium alloy TC 4 surface.But the gradient-structure artificial hip joint mortar cup of this method preparation just has biological coating on the surface, its agent structure still is metal material, do not meet the biological structure of human body acetabular bone, and face coat can produce obscission inevitably in the life-time service process, and this will cause the rejection of health.

Summary of the invention

The present invention will have than the hydroxyapatite of high bioactivity and biocompatibility preferably compound the preparing of ultra-high molecular weight polyethylene have apery body gradient hip cotyle cup, can slow down the bone dissolving of artificial joint in the normal wear situation and the generation of prosthetic loosening, prolong the service life of artificial hip joint, alleviated slight illness and the financial burden of user.

Technical scheme of the present invention is:

A kind of gradient-structure manual acetabulum mortar cup, whole acetabular bone mortar cup is formed by stacking by multilamellar medicated cap shape mortar body, each monolayer medicated cap shape mortar body adopts percentage by volume to be not more than 31.5% hydroxyapatite and molecular weight and is not less than 3,000,000 ultra-high molecular weight polyethylene and is composited, and the content of hydroxyapatite successively successively decreases from inside to outside.

The present invention has following characteristics:

1, added hydroxyapatite in the composite among the present invention, the main component of organism Endoskeleton inorganic salt, thereby have higher biological activity.Can not cause because of the immunoreation of organism self absorption and the dissolving of Periprosthetic sclerotin even in its use procedure, produce requisite abrasive dust yet, and then effectively reduce the phenomenon of prosthetic loosening.

2, the artificial hip joint mortar cup integral body of the present invention preparation is that ultra-high molecular weight polyethylene composite material by the different hydroxyapatite content of multilamellar is formed by stacking, have the biological gradient structure similar to the organism acetabular bone, can effectively satisfy acetabular bone in different motion pattern and characteristics such as Stress Transfer under the different stressed time.

3, the raw material of preparation artificial hip joint mortar cup is to have the good superhigh molecular weight polyethylene material of good chemical stability and biocompatibility and wear resistance and have hydroxyapatite than high bioactivity among the present invention, and contains a large amount of hydroxyapatite at the gradient layer that acetabular bone contacts with femoral head and help human body self osteocyte in its superficial growth.

4, the composite that adds a certain amount of hydroxyapatite preparation in the ultra-high molecular weight polyethylene matrix material and pure ultra-high molecular mass polyethylene material are under identical load, the former coefficient of friction is than the latter little (as shown in table 1), and when high capacity (1200N) the former wear rate than the latter little (as shown in table 2).

Respectively organize the coefficient of friction of sample under table 1 different loads

Annotate: 1, HA content represents the volume content of hydroxyapatite in the composite;

2, fusing sample is the pure ultra-high molecular mass polyethylene friction sample with reference to now prior art preparation.

Respectively organize the wear rate of sample under table 2 high capacity

In the table, HA content represents the volume content of hydroxyapatite in the composite; Fusing sample is the pure ultra-high molecular mass polyethylene friction sample with reference to now prior art preparation.

Description of drawings

Fig. 1 is that the master of the artificial hip joint mortar of the embodiment of the invention looks schematic diagram.

Fig. 2 is that schematic diagram is looked on the right side of the artificial hip joint mortar of the embodiment of the invention.

Fig. 3 is the cutaway view of the artificial hip joint mortar of the embodiment of the invention.

Among the figure: 1 monolayer medicated cap shape mortar body.

The specific embodiment

Be described in detail specific embodiments of the invention below in conjunction with technical scheme and accompanying drawing.

Shown in accompanying drawing 1-3, during making, carry out first the making of monolayer medicated cap shape mortar body: hydroxyapatite is dispersed in the medical liquid paraffin, adds ultra-high molecular weight polyethylene after 12 hours, adopt sol-gel process to prepare the composite that contains solvent.Solvent-laden composite is complete with n-hexane extraction, and in 60 ℃ convection oven, sample is dried.The composite of oven dry is put into customized mould in 150 ℃ of preheatings 5 minutes, then under this temperature, apply 3MPa pressure and kept 30 minutes, then sample is cooled to room temperature.

After monolayer prepares, in the customized mould of different-diameter, adopt identical condition compressing respectively in the composite of different hydroxyapatite content.Be placed on after the monolayer material of different hydroxyapatite content put well in order in the mould 150 ℃ of lower preheatings 10 minutes, then apply 3MPa pressure, and keep being cooled to after 30 minutes the artificial hip joint mortar cup that room temperature obtains having gradient-structure.

Claims

1. gradient-structure manual acetabulum mortar cup, it is characterized in that, whole acetabular bone mortar cup is formed by stacking by multilamellar medicated cap shape mortar body, each monolayer medicated cap shape mortar body adopts percentage by volume to be not more than 31.5% hydroxyapatite and molecular weight and is not less than 3,000,000 ultra-high molecular weight polyethylene and is composited, and the content of hydroxyapatite successively successively decreases from inside to outside.