CN102861369B - Slidable elastic valve bank for prefilling disposable syringe - Google Patents

Abstract

A valve bank suitable for prefilling disposable syringes is provided with an inner cavity for storing products for injection, or two independent inner cavities (2) and (3) for storing products (9) and (10) which are separated from each other and are to be mixed before injection, wherein the valve bank is used as a temporary blocking mechanism for blocking the communication between the two inner cavities or between the inner cavities and a pipe communicated with a syringe needle, and the valve bank comprises two cooperated discoid elements (4) and (5) located in a main body (1) of the syringe. The discoid elements has an outer edge leaned against a cylindrical surface of the main body, wherein one of the elements is a slidable elastic discoid plug (4) acting on the second element, and the second element is a receiving slidable discoid seat (5). Edges (19) and (20) which are thicker and smaller in elasticity then other parts of the main body of each element are defined at the bottoms of the two discoid elements. The valve bank is characterized in that the slidable elastic discoid plug (4) comprises an elastic bottom with several holes (14). A hollow blocking plunger (13) with an open bottom extends through the inside of the elastic bottom; and the slidable discoid seat (5) comprises a middle channel pipe (15) relative to the blocking plunger (13); the blocking plunger (13) comprises an inside inlet surrounding an outer cavity to maintain communication with the pipe; The valve bank is also characterized in that the the blocking plunger (13) extending through elastic bottom of the valve plug (4) has a round part with an external diameter slightly larger than the diameter of the channel pipe (15) of the receiving discoid seat (5).

Description

For the slideable feather valve group of pre-filled disposable syringe

Technical field

The present invention relates to keep each assembly be separated completely and sterilize, preventing the slideable valve of the elasticity for the pre-filled disposable syringe group of their contact needles before the injection.

This valve group owing to showing one's talent adopting the elastic mechanism of same parts composition to be integrated with novel modification in construction, its significantly enhance internal composition mixing and obtain solution effectively and discharge completely.

More specifically, the present invention relates to new valve set type, its discoid element of being joined by two associations forms, and one of discoid element is the slideable elasticity plate-like valve plug being used as to receive plate-like valve seat, and this plate-like valve seat is also slidably.

Consider that the amendment of combination is to guarantee that the solution obtained by the internal mix of component can be discharged completely by the independent injection of syringe.

In order to obtain the result described in above paragraph, the modification in construction be incorporated in the valve that two associations join mentioned eliminates all probabilities of less desirable displacement, the inside that described less desirable displacement can completely or partially be blocked between the chambers is communicated with, and affects the flowing of fluid towards injection needle thus.

The present invention is that the novel combination of improved mechanism is unforeseeable and even concerning better result all surprised expert to obtain.Therefore, except the characteristic of its novelty, in order to be considered to patent of invention, the conception of its 26S Proteasome Structure and Function indicates invention function clearly in the mode of the requirement determined in accordance with law.

Prior art

Pre-filled syringe generally includes has outside and inner hollow circle tube main body, and this outside limits the axle collar be communicated with injection needle, the plunger that this inside comprises axial location and can manually slide, and it stretches out from the base end part opened wide relative to the axle collar.In these cases, variable-displacement internal chamber is limited, as the terminal for goods to be injected.Described chamber comprises the cylindrical wall of main body, coordinates the described outer collar of injection needle, and manually can slide and fit snugly in the plunger head in the cylindrical wall of main body.

Lid around and join syringe needle to, keep its sealing and be separated, and it also joins syringe to and causes of short duration seal closure.

Based on previously mentioned base structure, can have many products, the inside of wherein said main body is also separated into two adjacent and coaxial variable-displacement chambers.Described chamber is by the cross-section baffle for separating of inside, and inner cross-section dividing plate comprises the valve system for being communicated with between chamber.

These syringes are known as dual cavity pre-filled syringe, and for storing two kinds of different liquid components or a kind of liquid component and another kind of powdery components, these components must be separated completely and keep before the injection being separated.In fact, when this kind of dual cavity pre-filled syringe, the described internal valve mechanism design forming the dividing plate between chamber is that user before the injection can mixed product and can not being polluted by exogenous impurity, that is, keeps initial separation.Only have upon mixing, the lid of syringe needle can be opened and the mixture obtained can flow into the syringe needle of injection.

In order to obtain mixture in described separation, the general plunger that uses is to move in contrast to the direction of injection.Due to this movement, in adjacent chamber, create malleation and low pressure, and described interior valve system is opened the connection of the mixing of setting up permission two kinds of goods, and the mixture be simultaneously stored in single chamber prepares injection.

Once obtain described mixing, user can only be had to carry out injection and be made mixture flow to syringe needle.

The product defining the various structures of the described inner valve dividing plate of adjacent chamber is known, and wherein adjacent chamber holds the goods be separated.Described known product is accurately distinguished by the valve system be incorporated in they each.

But produce inconvenience from the analysis of these internal valves, namely valve system is always designed for each specific occasion especially, and that is, described mechanism can only be applied to the syringe body adapting to mechanism in 26S Proteasome Structure and Function mode.

In other cases, exist and be adjusted to the valve element of conventional syringe main body, but require accessory or the constructional variant of some main bodys equally, all ultimate costs that these increased syringe and make its structure and filling become complicated.

Valve group of the present invention belongs to the set of those groups of the syringe body adapting to any conventional, comprises those groups with a chamber and those groups with two chambers.

The design of the 26S Proteasome Structure and Function of valve group has considered the condition of the conventional syringe being adapted to any type; It does not change the fact of filled articles to the automated procedure of syringe, particularly when dual cavity pre-filled syringe; And mixed process and injection after a while do not need the fact of special duty.

Also should be noted that and in pre-filled dual cavity syringe, play effective effect in order to realizing valve group, coordinate the described syringe axle collar of injection needle and its lid by stopper or be alternatively kept fluid and be separated with needle wall until it is important that the appropriate members of injecting is blocked, to guarantee joint and to go joint can not produce any less desirable leakage and spilling.

This kind of valve group comprises name and is called " CONJUNTO VALVULAR y DESLIZANTEAPTO PARA ACTUAR EL INTERIOR DE JERINGAS PRLLENADAS " (being applicable to the slideable feather valve group being applied to inner pre-filled syringe), Argentina patent of invention AR026823B, 1 (its everyone, Jaime Luis Szapiro, Sa ú l Moreno y Leonardo Szames, identical with applicant of the present invention) situation, it has an inner chamber of the goods holding injection, or the type of two of the goods of each self-separation that must mix before holding injection independent inner chambers, and wherein this valve group is as the mechanism for implementing of of short duration sealing, described in the device obstruction of this of short duration sealing between inner chamber or with being communicated with between the pipe extending to injection needle.

This valve group comprises the discoid element that two associations join, and is positioned at the main body of syringe, and outer rim leans against on the cylinderical surface of main body; One of them element is slideable elasticity plate valve, and another element is the slideable plate-like seat that described plate valve is applied to it simultaneously.This plate valve has the elastic bottom comprising multiple hole, and short column extends from described hole relative to the respective channel be limited to the bottom of described slideable plate-like seat.

The external margin of the bottom of the discoid element that two associations join is called edge, and these edge are thicker than the remainder of the main body of each valve element and elasticity is less.

According to this explanation, the discoid element that the described association being positioned at the body interior be communicated with the axle collar of syringe joins, can as the of short duration close mechanism axle collar of syringe with a pre-filled chamber.Once described discoid element with block the valve plug of the axle collar and be combined, equally can as of short duration close mechanism in as the two-chamber pre-filled syringe of the dividing plate between described chamber.

Verified once produce for the mixture injected and plunger moves forward, the described slideable elasticity plate-like valve so supported the blocking post of the passage be limited on slidably plate-like seat is positioned at the position allowing passage release, but still trends towards its blocking position.

In fact, sometimes when user is injected, he can find that described blocking post enters in the access opening of plate-like seat improperly, as less desirable stopper and the motion bringing repetition initial will fill in the needs that retract with release channel.

This is because described blocking post aligned with channel hole, although and the diameter of the bar end that is a bit larger tham the diameter bar in hole be not the fact of cup-shaped.Therefore, bar is in place by the pressure assembling of plunger, produces less desirable blocking.

In this case, it is enough to the motion repeating to fill, retracted by plunger, to make bar uncoupling.

Summary of the invention

Advantage

Slideable elastic seat for disposable pre-filled syringe as referred to herein also comprises the discoid element that two associations join, and be positioned at the main body of syringe, its outer rim leans against on the cylinderical surface of main body; One of them element is the slideable elasticity plate-like valve plug acted on another element, another element described receives slideable plate-like valve seat.

Discoid element all has the outer rim of the cylinderical surface against syringe body.Described edge is thicker than the remainder of the main body of each discoid element and elasticity is less.

The valve plug of valve group of the present invention comprises the elastic bottom with multiple hole.Coaxial blocking elastic cylinder extends from the inner side of described bottom, and has open bottom due to its hollow structure.

Just in time the phase and phase center-aisle pipe of answering is relatively and be positioned at the bottom of described slideable reception plate-like seat for this elastic cylinder.The diameter of tube portion is slightly smaller than the diameter of described cylindrical shell.

Similarly, the feature of described reception plate-like seat is the chamber having two diameters relative, the outlet of the contiguous center-aisle pipe in described chamber; Even if also allow fluid to flow when described blocking cylindrical shell is positioned at the position of the described outlet of its block via.

Owing to having the structure of the cylindrical shape blockage mechanism bottom its open end, be characterized in that fluid pressure self prevents from receiving plate-like seat passage during injecting.

But once described blocking cylindrical shell blocks the release outlet of described passage, so the difference of diameter coordinates preventing it in the intervalve of passage, causes closure function.In this case, the described exocoel of the entrance of contiguous described channel outlet guarantees that during injecting the persistent loop of fluid is to discharge outlet.

Once think that this is necessary, so the present invention considers that the entrance that can show as the described intervalve of adjacent channel has multiple exocoel.

Invention effect

Current, not used for the known dielectric film of bridging effect, from previous paragraph, even do not imply the proposition of structural solutions.Therefore, the application is not only novel, but also presents clearly original behavior.

Accompanying drawing explanation

Except user or expert can add except the advantage in the present invention; the structure of feather valve group, the characteristic of Structure and function of invention is also helped to understand in order to describe the concise and to the point advantage described in detail; below describe and preferred embodiment is shown; it provides the particular range do not had in additional page schematically; owing to being the fact of preferred embodiment, the explanation of phrase is not limited to or gets rid of the protection domain of patent of the present invention.The preferred embodiment be intended to explain and illustrate the present invention based on basic conception.

Fig. 1 is the viewgraph of cross-section that two elements forming feather valve group of the present invention are shown separately.

Fig. 2 is similar with foregoing figures but when described element is engaged viewgraph of cross-section.

Fig. 3 be also similar with previous two width accompanying drawings, the viewgraph of cross-section being positioned at and direction of flow can be made to inject two elements of the valve group of the present invention in the centre position exported is shown.

Fig. 4 is the axonometric chart of the slideable plate-like valve plug of elasticity that one of observation outside it, two elements forming valve seat of the present invention are shown.

Fig. 5 is the axonometric chart of the slideable plate-like valve plug of elasticity that one of observation inside it, two elements forming valve seat of the present invention are shown.

Fig. 6 is axonometric chart observation outside it being shown, forming the slideable plate-like seat of reception of another element of valve seat of the present invention.

Fig. 7 represents the axonometric chart observing, form the slideable plate-like seat of reception of another element of valve seat of the present invention inside it.

Fig. 8 is vertical longitudinal view that variable-displacement dual cavity pre-filled syringe is shown, when it commercially provides, valve group of the present invention is in spare space wherein.

Fig. 9 is also similar with foregoing figures, that valve seat present position of the present invention carry out mixed process in syringe during is shown longitudinal view.

Figure 10 is also similar with foregoing figures, that the position completed in syringe after mixed process residing for valve seat of the present invention is shown longitudinal view.

Figure 11,12,13 be similar with foregoing figures, illustrate and will belong to longitudinal view of the valve position of components of valve group of the present invention when being used for injecting when transmitting the mixture obtained.

Figure 14 and 15 is similar with foregoing figures, that the valve position of components of the valve group of the present invention when injecting is shown longitudinal views.

Figure 16 illustrates longitudinal view with variable-displacement traditional double chamber syringe, wherein also comprises valve group of the present invention, but in this case to overturn mode normal valve element.

Figure 17 is the longitudinal direction figure similar with foregoing figures, and it illustrates the operation of the valve element when the goods flowing mixed is to inject.

It is worth mentioning that, according to by the preferred embodiment of valve seat of the present invention selecting to describe, the parts of the identical or equivalence of valve group or composed component adopt identical Reference numeral in all of the figs.

Detailed description of the invention

As seen in figures 1 and 3, in the present invention, the slideable elastic seat for pre-filled syringe of indication comprises the element that two associations join, and is referred to by Reference numeral 4 and 5.

The element that the association referred to by Reference numeral 4 joins is slideable elasticity plate-like valve plug, it comprise there is slightly cup-shaped form, circular dimension elasticity plate-like bottom, be limited with multiple hole 14 thereon.Surrounded by thicker and harder periphery ring 19 bottom described plate-like.

The special feature of described plug is that the hollow of coaxial positioning is blocked the inner side that cylindrical shell 13 has complete open bottom from it and extended.

Second element is referred to by Reference numeral 5, has been envisioned for and has made described plate-like plug 4 can produce the closedown of valve or open, and is used as to assist the reception plate-like seat of joining.This element is preferably circle, and have central passage pipe 15 and respective periphery ring 20, this periphery ring is thicker than the other parts of main body.

According to the present invention, the feature receiving plate-like seat 5 is that the entrance of the pipe 15 of the obstruction cylindrical shell 13 relative to valve plug comprises at least two outer adjacent cavities 21 and 22, and these chambeies have short height, and each chamber is communicated with described channel 15.

These assist the element of joining according to described valve close with opening action necessarily together with operate.In order to do like this (as shown in Figure 2), the top of assisting one in the element of joining must be placed on the element that second association joins and both must aim at, described obstruction cylindrical shell 13 can be engaged in pipe 15 tightly, provide approach to the seal closure preventing goods from flowing through pipe.

According to the present invention, once plug 4 is against plate-like seat 5, described exocoel 21 and 22 guarantees that fluid can flow to exhaust outlet without difficulty.

With reference to the accompanying drawings 8 to 15, be appreciated that the operation when valve of the present invention is applied to dual cavity pre-filled syringe.

Longitudinal view of these accompanying drawings shows its conventional syringe provided before the injection effectively, that is, corresponding goods 9 and 10 are suitably separated between which and isolate and be suitably separated with the external world and isolate, and are stored in the corresponding chambers of the variable capacity 2 and 3 in syringe body 1.

Known syringe has the corresponding injection needle 11 be enclosed in lid 12.This lid joins the axle collar 18 to, and this axle collar is arranged in the top of syringe, hermetically enclosedly sets up inner connection with the position of the closed upper part plug 16 of suitably isolation thus comprising setting up.

These accompanying drawings clearly show front chamber 2 by valve seat 4 or 5 of the present invention at its bottom portion defining, are defined at its sidepiece by the inner side of the cylindrical wall of main body 1, and are defined outside it by the described valve plug 6 comprising the goods 9 being in separate mode.

Similarly, the rear chamber 3 of goods 10 storing appropriate separation is defined at an upper portion thereof by valve seat 4 or 5, is defined by 7 of the inner side of the cylindrical wall of main body 1 and plunger 8.

According to condition recited above, as as shown in Fig. 8,9 and 16, in described chamber 2 and 3, store goods 9 and 10 is feasible, and goods 9 and 10 can be two kinds of liquid components, or a kind of liquid and a kind of powdery components, be stored in both cases in any one of two chambers.

According to Fig. 8,9 and 10, the operation of valve group of the present invention during the mixing starting goods 9 and 10 before the injection can be seen.In order to do like this, user pulls back plunger 8 along direction F (direction relative to injection), causes the low pressure in chamber 3 to produce the displacement of plate-like seat 5, the connection between release chamber 2 and 3, owing to being separated, goods 9 flow through the hole 14 of valve plug 4 and the central canal 15 of discoid element 5.

Figure 10 illustrate described element 4 with 5 position with from be stored in chamber 3 be isolated from the outside and be communicated with in injection needle isolation described goods 9 and 10 mixing obtain obtaining of solution 16.Be characterized in that plate valve 5 also keeps the connection between two chambers 2 and 3 thus relative to valve plug 4 displacement.

Figure 11,12 and 13 illustrate when user along during the displacement plunger 8 of F1 direction by set up be communicated with caused by result, described solution 16 flows to chamber 2 from chamber 3, prepares to inject in the mode identical with any single chamber pre-filled syringe.

Pressure from plunger 8 causes the obstruction cylindrical shell 13 of valve plug 4 to be feasible against the entrance of channel 15, and fluid flowing in this case can not be affected, because it preferably flows through outside adjacent cavities 21 and 22.

In the sense that, the solution in conjunction with novel structure in the present invention comprises the obstruction cylindrical shell with open bottom, and it can not be engaged in pipe 15 to block connection.The fluid pressure flowing to exhaust outlet is tending towards expanding cylindrical shape wall, to guarantee that its circular portion is larger than the circular portion of described pipe 15.

But, as as shown in Figure 13,14 and 15, in conjunction with the solution of novel structure comprise the described exocoel 21 and 22 of the connection entrance of contiguous described passage 15 pipe, make once described obstruction cylindrical shell remains against on the entrance of channel 15, fluid just can normally flow through described chamber.

Figure 13 to 15 illustrates that wherein lid 12 removes in advance when user makes the pressure dislocation valve 6 that produced by fluid 16 and described fluid flows through injection needle 11 along F1 direction mobile plunger 8.

Figure 16 and 17 illustrate when valve element 4 and 5 be in obtain during change place valve operation.In the case, when user is along F direction mobile plunger, valve plug 4 by dislocation to change its elastic bottom, cause obstruction cylindrical shell 13 from its sealing seat dislocation and set up between inner chamber and be communicated with, make the goods be stored in chamber 2 can flow through pipe 15 and flow towards chamber 3 in hole 14, to form the mixture of goods 9 and 10.

Obviously the solution being combined in the novel structure in this valve seat makes it be applied to any traditional pre-filled syringe.

In fact, in these cases, valve group 4 and 5 is located in such a way, that is, it blocks and being communicated with of the interior axle collar 18, and makes independent chamber by valve group 4 or 5 at its front bottom portion defining, and by the cylindrical wall of main body 1 and chock plug 7 at its end bottom portion defining.

In this case, user also pulls back and produces inner hypobaric plunger, and the elasticity of producing component 4 changes, and connection is opened in the displacement of blocking cylindrical shell 13 thus, and the goods stored are discharged towards injection needle.

Claims (7)

1. for the slideable feather valve group of pre-filled syringe, there is the inner chamber stored for the goods injected, or there are two independent inner chambers (2, 3), to be stored in the goods (9 of the isolation of injection forward slip value, 10), wherein this valve group is as the temporary transient close mechanism be communicated with between inaccessible described inner chamber, or be used as the inner temporary transient close mechanism be communicated with of the inaccessible axle collar (18) be connected with the injection needle in the axle collar (18) being limited to syringe (1), the discoid element (4 that two associations comprising the main body (1) being positioned at syringe join, 5), and its outer rim leans against on the cylinderical surface of main body, one in these elements is the slideable elasticity plate-like plug (4) acted on the second element, second element receives slideable plate-like seat (5), the bottom margin of described discoid element is rendered as edge (19, 20), described edge is thicker than the remainder of the main body of each valve element and elasticity is less, its characteristic is, slideable elasticity plate-like plug (4) comprises the elastic bottom with multiple hole (14), hollow blocking plunger (13) with open bottom extends from the inside of described elastic bottom, simultaneously, the feature of slideable reception plate-like seat (5) is to have the center-aisle pipe (15) relative to described blocking plunger (13), described blocking plunger (13) has by chamber (21, 22) interior inlet surrounded, described chamber (21, 22) keep being communicated with described center-aisle pipe (15) inside.

2. the slideable feather valve group for pre-filled syringe according to claim 1, it is characterized in that, its blocking plunger (13) extends from the elastic bottom of slideable elasticity plate-like plug (4), described slideable elasticity plate-like plug (4) has circular portion, and this circular portion has the overall diameter slightly larger than channel (15) diameter receiving slideable plate-like seat (5).

3. the slideable feather valve group for pre-filled syringe according to claim 1, it is characterized in that, keep having with the inner chamber (21,22) be communicated with of the described center-aisle pipe (15) of holding described reception slideable plate-like seat (5) two diametrically chamber respect to one another (21,22).

4. the slideable feather valve group for pre-filled syringe according to claim 1, it is characterized in that, the center-aisle pipe (15) receiving slideable plate-like seat (5) has by the outlet that in described chamber, at least two are surrounded, and described chamber is communicated with the inside of center-aisle pipe (15).

5. the slideable feather valve group for pre-filled syringe according to claim 1, it is characterized in that, the blocking plunger (13) extended from slideable elasticity plate-like plug (4) comprises outer annular lug, and described lug is provisionally against the cylinderical surface of the center-aisle pipe (15) of the slideable plate-like seat (5) of reception.

6. the slideable feather valve group for pre-filled syringe according to claim 1, is characterized in that, assists the discoid element of joining to be positioned in the inside that main body is communicated with the axle collar of syringe, as the temporary transient close mechanism of single chamber pre-filled syringe.

7. the slideable feather valve group for pre-filled syringe according to claim 1, it is characterized in that, the discoid element (4 that the association combined with the valve plug (6) of the axle collar (18) blocking syringe (1) joins, 5), as having the dual cavity (2 be positioned at coaxially in syringe, 3) the temporary transient close mechanism of pre-filled syringe, and as the separation between each chamber.