CN102836653A - Liquid drop mixing unit based on electro-wetting digital micro-fluid chip - Google Patents
Liquid drop mixing unit based on electro-wetting digital micro-fluid chip Download PDFInfo
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- CN102836653A CN102836653A CN2012103512445A CN201210351244A CN102836653A CN 102836653 A CN102836653 A CN 102836653A CN 2012103512445 A CN2012103512445 A CN 2012103512445A CN 201210351244 A CN201210351244 A CN 201210351244A CN 102836653 A CN102836653 A CN 102836653A
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Abstract
The invention belongs to the technical field of digital micro-fluidics, and in particular relates to a liquid drop mixing unit based on an electro-wetting digital micro-fluid chip. The mixing unit comprises three parts consisting of an inlet zone, a mixing zone and an outlet zone; the fast, high-efficiency, automatic and reliable mixing of the liquid drops can be realized via the special bidirectional driving electrode and closed-loop electrode arrangement and simplified electrode connection mode. The liquid drop mixing unit has the advantages of novel design, easiness in control, high reliability, excellent practicability, high automation degree, and the like, so that the liquid drop mixing unit can be widely used in various digital micro-fluid chips.
Description
Technical field
The invention belongs to digital microfluidic technology field, be specifically related to relate in particular to a kind of drop mixed cell based on the wetting digital micro-fluid chip of electricity based on the medium wetting digital microfluidic technology chip that powers on.
Background technology
(Lab-on-a-chip LOC) as an emerging technology, owing to have many advantages such as high integration, high accuracy, low consumption, is just receiving increasing concern to chip lab, has excellent research and application prospect.And so-called chip lab is meant that can accomplish biochemistry handles each process, can accomplish the sophisticated functions microminiaturization of traditional experiment chamber task, integrated MEMS system automatically.Its target is an integrated analytic process completely on individual devices, can accomplish behaviour such as sample extraction, sample pretreatment, decomposition and separation, biochemical reaction, analyzing and testing, data and do.As the power section of chip lab, microflow control technique plays crucial effects.And be meant through applying voltage based on the wetting digital microfluidic technology of electricity and control a microfluidic technology of single drop because have relatively simply, controllability and driving force preferably, it is the most feasible in using to be considered to LOC, the technology of tool development prospect.
At present based on the wetting function of digital microfluidic technology on practical chip of electricity mainly concentrate on distribution, transport, mix fluid sample, multiple processing such as extraction, separation; And this function of the mixing of sample is most important; Being the foundation that digital micro flow chip is used, is the key of chip lab microminiaturization, automation, commercialization.
In present electric wetting digital micro flow chip; The mixing of sample main two big class methods: the first kind is simple direct mixing the on the chip, promptly merges through driving two kinds of sample drop, makes the merging drop transport the stretch footpath thereafter; In transport process, two kinds of samples are realized slowly mixing.This method is exactly to utilize the drop of digital micro flow chip to merge and transportation function in fact, can directly utilize the drive electrode of chip, and method is directly simple, does not need the additional functionality unit.But also there is distinct disadvantage in this method; At first be that mixing rate is very slow; Because it is to rely on the drop transport process of traditional die to accomplish; And traditional drop transports the path that can only take the air line, and the mixing efficiency of drop is very low like this, needs long drop transport path or long incorporation time.Secondly, because the mixing of drop does not have special-purpose functional unit, and the mixing of drop long period transports the pollution that can cause chip.At last owing to receive the constraint of the common drive electrode of chip, to mix the size dimension of drop restricted.And second type of mixed method is to adopt extra householder method; For example methods such as integrated sonication, magnetic agitation are mixed on digital micro flow chip; This type mixed method can obtain mixing efficiency and effect preferably; But need extra functional unit, increased the complexity and the commercial cost of chip, and the integrated level limit microminiaturization of micro flow chip.
Therefore, need a kind of simplely, good mixing effect, mixing efficiency is high, integrated level is high, cost is low drop mixed function device are to be integrated in the digital micro flow chip, to satisfy the application requirements of chip lab.
Summary of the invention
The present invention aims to provide a kind of drop mixed cell based on the wetting digital micro flow chip of electricity, to be integrated in the digital micro flow chip, can realize simple, the high efficient mixed of drop.
Mixing principle of the present invention is based on transporting of drop, promptly through with drop in a certain way the certain path of rapid transportation to reach the purpose of automatic mixing.
Drop mixed cell based on the wetting digital micro flow chip of electricity provided by the invention comprises three parts:
First is the inlet region of mixed cell; This part mainly is that the traction drop gets into mixed cell; The drive electrode of intake section can be an absolute electrode; It also can be the part of mixed cell internal drive electrode electrode; The shape size of electrode does not limit, and can the outer drop of mixed cell be transported to the combination drive electrode in the mixed cell as long as satisfy.The position and the number of inlet do not limit yet.
Second portion is the mixed zone of mixed cell; This part is the main functional parts of mixed cell, implements the high efficient mixed to drop.This part is made up of the unidirectional drive electrode.Each drive electrode head and the tail leans on mutually, the circulus of mutually nested formation sealing, and the mixed path that makes drop is the annulus curve.Utilize and to design, make drop, can improve the mixing efficiency of drop so widely no matter in that motion is curve in the motion of single electrode or on the whole piece mixed path; And this part uses and simplifies electrode and link to each other, and is electrically connected alternate electrode, makes the minimum control signal of whole mixed cell be two like this, greatly simplified the control system.In this part, the drive electrode of mixed cell is at least 4, but and no maximum, be arranged into annular enclosed structure as long as can guarantee electrode.
The unidirectional drive electrode of this part can adopt following frame mode.Electrode shape is asymmetric discrete electrodes; Each electrode is divided into 3 parts: the one, be the electrode head that corynebacterium and top are circular arc (E41); This part is used for when beginning, drawing the adjacent electrode drop to this electrode, and the top is a circular arc, to increase the drop driving force; The 2nd, have the electrode middle part (E42) of round breach, this part is that drop begins to contact drive electrode and is stabilized in the excessive part of drive electrode to drop, the effect of circumferential notch is increase drop driving force and one-way; The 3rd, the circular-arc and afterbody electrode afterbody jaggy (E43) of square, this part is the steady component of drop on drive electrode, the afterbody breach be convenient to nested with the head of adjacent electrode; Whole electrode structure satisfies following condition: for a certain size drop, no matter it is in any position on the electrode, as long as an effective coated electrode part applies the driving signal to electrode, it can both finally arrive the steady component of electrode afterbody;
Third part is the outlet area of mixed cell; This part mainly is the drop output with mixed cell; The drive electrode of exit portion can be an absolute electrode; It also can be the part of mixed cell internal drive electrode electrode; The shape size of electrode does not limit, thereby but will satisfy the drop that is in this part and can effectively touch the combination drive electrode and make drop can import mixed cell to mix.The position and the number of outlet do not limit yet.
The mixed cell that should be pointed out that traditional digital micro flow chip does not clearly define inlet, outlet, and definition of the present invention helps drop and passes in and out mixed cell fast, and can effectively combine with other functional unit of micro flow chip.This is one of innovative point of the present invention.
And in the present invention, the transport path when utilizing the circular path of asymmetric drive electrode and sealing that drop is mixed is not straight line, can improve mixing efficiency so greatly, and this is again an innovative point of the present invention.
In addition, in the present invention,, do not need to know in advance the drop position, only need that two drive electrodes are applied drive that signal promptly can realize drop High-Speed Automatic in turn and transport mixing owing to use the unidirectional drive electrode and simplify electrode connection mode.
Among the present invention, said " unit " is meant the organic assembling of a plurality of parts with certain function.
Among the present invention; Said " drop " is meant the drips of solution that can be used for electric wetting driving; Its composition can be single biological sample, chemical solution etc., also can be that multicomponent is formed, and the drop of one deck oil film etc. like coated outside; Its size does not limit, and can be raised to slightly between some milliliters for inferior.
Among the present invention, said " drive electrode " is meant that the voltage of counter electrode when chip is implemented is set to and is not 0 so that electric wetting driving can take place, and said " earth electrode " is meant that the voltage of counter electrode when chip is implemented is set to 0 or with 0 enough approaching.
Among the present invention, said " mutually nested " is meant between the drive electrode that some comprises the district how much, but on electric, do not link to each other, and when touching certain part of a certain drive electrode with the bonding drop, it also can exposure phase answers the part of adjacent electrode.
Drop mixed cell provided by the invention has following significant advantage:
1. directly utilize the drop transportation function, simple and convenient, be easy to integrated;
2. have the import and export part, can realize that drop passes in and out fast, and can effectively combine with other part;
3. compare with the conventional hybrid method, have mixing rate and better mixing effect faster;
4. mixing portion only needs two and drives signal, greatly reduces the control complexity;
5. utilize unique unidirectional electrode, can realize full-automatic mixing, have higher reliability;
6. utilize unique electrode configuration, can make the combination drive electrode number increase the control that does not but influence chip arbitrarily.
Description of drawings
Fig. 1 is the wetting digital micro-fluid chip structural representation of a kind of electricity of drop mixed cell of the present invention.
Fig. 2 is the drop mixed cell sketch map based on the wetting digital micro-fluid chip of electricity of the present invention.
Fig. 3 is a kind of unidirectional drive electrode structure diagram of the present invention.
The specific embodiment
Drop mixed cell based on the wetting digital micro-fluid chip of electricity provided by the invention can have multiple concrete chip implementation, and this embodiment is only enumerated a kind of common digit chip structure and implemented principle so that it to be described.Should be pointed out that this embodiment is to provide for illustration purpose, and pay no attention to limiting by any way scope of the present invention.
As shown in Figure 1 based on the wetting digital micro-fluid chip structure of a kind of electricity of the present invention.On substrate 11 mixed cell drive electrode 1-4 of the present invention.Fixing as the material of substrate, as long as insulation, as can be for the silicon chip of quartz, glass, insulation etc.; And electrode (comprising earth electrode described below) can be made up of any conductive material.Should explain; The combination drive electrode of sketch map is an example with 4 only, but its actual number do not limit, and the position of the just simple expression electrode of drive electrode in chip among the figure; Do not reflect it in detail and specifically arrange and connected mode, and be not described in detail chip structure.Electrode 1-4 goes up to dielectric layer 12, is hydrophobic layer 13 on it.Should be pointed out that dielectric layer should be the dielectric material but do not limit, and is preferably the material that dielectric constant is higher, breakdown characteristics is stronger.Substrate 11, drive electrode 1-4, dielectric layer 12, hydrophobic layer 13 have constituted the bottom crown 1 of chip jointly.On bottom crown driven droplet D; On the drop hydrophobic layer 23, medium 22, and basic 21, they have constituted the top crown 2 of chip jointly.The structure of entire chip is that drop is clipped between the bottom crown, and 1-4 applies voltage signal on request when the bottom crown drive electrode, and during top crown earth electrode ground connection, and drop will corresponding generation drives and transports, thereby realizes high-speed mixing.
Fig. 2 is the drop mixed cell sketch map based on the wetting digital micro-fluid chip of electricity of the present invention.Mixed cell is formed nested closed-loop structure by 4 drive electrode 1-4, realizes mixing in order to transport drop; Mixed cell comprises an inlet 5; The form that should be pointed out that inlet electrode 5 does not limit, can for independently electrode and electrode shape according to specifically changing; This explanation is only disposed with the mode of simplifying; With the inlet electrode 5 of a certain shape with transport drive electrode 1 and link to each other, to realize common control, the function that does not influence mixed cell realizes.In addition, mixed cell also comprises an outlet 6, and the form of outlet does not limit yet, and the present invention is caved in as outlet with the part of electrode 2, in order to be connected with outer electrode with the mixed drop of convenient output.Whole mixed cell adopts the mode of simplifying to connect, and finally draws two and drives signal connection electrode A, B.When mixed cell adopts the chip structure configuration of Fig. 1; If drop is positioned at the driver element porch, like D1, through to connection electrode A time voltage drive signals; While chip top crown ground connection; Drop will get into mixed cell so, finally is in the stable place that a certain mixing in the mixed cell transports electrode, like D2.Thereafter, if keep chip top crown ground connection, through to connection electrode B time voltage drive signals, and A cancels the driving signal, and drop will and finally be stabilized in the stable place of electrode 2 toward electrode 2 motions, like D3.In turn A, B connection electrode are applied the driving signal with this, drop will be done annular at electrode 1,2,3,4 with this and transport, thereby realizes that drop mixes.If when drop is positioned at the stable place of electrode 2, like D3, cancel the driving signal of electrode A, B simultaneously, drop will keep motionless always, and can with drop export mixed cell through exporting 6 this moment.In this embodiment, input, mixing, output function that whole mixed cell can the Rapid Realization drop have greater efficiency and better effects.
Claims (3)
1. the drop mixed cell based on the wetting digital micro-fluid chip of electricity is characterized in that being made up of inlet region, mixed zone and outlet area three parts, adopts drop rapid transportation mode to realize mixing; Wherein:
The inlet region is used to draw drop and gets into mixed cell, and the drive electrode of inlet region part is an absolute electrode, or the part of mixed cell internal drive electrode electrode;
The mixed zone is a main functional parts, implements the high efficient mixed to drop; The mixed zone is made up of the unidirectional drive electrode, and each drive electrode head and the tail leans on mutually, the circulus of mutually nested formation sealing, and the mixed path that makes drop is the annulus curve;
Outlet area is used for the drop output with mixed cell, and the drive electrode of outlet area part is an absolute electrode, or closes the part of unit internal drive electrode.
2. according to the said mixed cell of claim 1; The following frame mode of unidirectional drive electrodes use that it is characterized in that said mixed zone: electrode shape is asymmetric discrete electrodes; Each electrode is divided into 3 parts: the one, be the electrode head that corynebacterium and top are circular arc (E41); This part is used for when beginning, drawing the adjacent electrode drop to this electrode, and the top is a circular arc, to increase the drop driving force; The 2nd, have the electrode middle part (E42) of round breach, this part is that drop begins to contact drive electrode and is stabilized in the excessive part of drive electrode to drop, the effect of circumferential notch is increase drop driving force and one-way; The 3rd, the circular-arc and afterbody electrode afterbody jaggy (E43) of square, this part is the steady component of drop on drive electrode, the afterbody breach be convenient to nested with the head of adjacent electrode; Whole electrode structure satisfies following condition: for a certain size drop, no matter it is in any position on the electrode, as long as an effective coated electrode part applies the driving signal to electrode, it can both finally arrive the steady component of electrode afterbody.
3. the application of drop mixed cell in the digital micro flow chip that unipolar plate drives, bipolar plates drives various structures according to claim 1.
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| CN201210351244.5A CN102836653B (en) | 2012-09-20 | 2012-09-20 | Liquid drop mixing unit based on electro-wetting digital micro-fluid chip |
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| CN103143406A (en) * | 2013-03-10 | 2013-06-12 | 复旦大学 | Two-dimensional digital micro-fluidic chip based on one-way liquid drop transport |
| CN103412024A (en) * | 2013-07-05 | 2013-11-27 | 复旦大学 | Integrated electrochemical sensing chip |
| CN104248997A (en) * | 2013-06-27 | 2014-12-31 | 李木 | Digital micro fluidic chip and control method thereof |
| CN105854117A (en) * | 2016-03-28 | 2016-08-17 | 南京理工大学 | Precise administration infusion device based on electrowetting on dielectric |
| CN110383061A (en) * | 2016-12-28 | 2019-10-25 | 米罗库鲁斯公司 | Digital microcurrent-controlled device and method |
| US11298700B2 (en) | 2016-08-22 | 2022-04-12 | Miroculus Inc. | Feedback system for parallel droplet control in a digital microfluidic device |
| US11413617B2 (en) | 2017-07-24 | 2022-08-16 | Miroculus Inc. | Digital microfluidics systems and methods with integrated plasma collection device |
| US11471888B2 (en) | 2015-06-05 | 2022-10-18 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| US11524298B2 (en) | 2019-07-25 | 2022-12-13 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
| US11623219B2 (en) | 2017-04-04 | 2023-04-11 | Miroculus Inc. | Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets |
| US11738345B2 (en) | 2019-04-08 | 2023-08-29 | Miroculus Inc. | Multi-cartridge digital microfluidics apparatuses and methods of use |
| US11772093B2 (en) | 2022-01-12 | 2023-10-03 | Miroculus Inc. | Methods of mechanical microfluidic manipulation |
| US11944974B2 (en) | 2015-06-05 | 2024-04-02 | Miroculus Inc. | Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling |
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| CN103412024A (en) * | 2013-07-05 | 2013-11-27 | 复旦大学 | Integrated electrochemical sensing chip |
| CN103412024B (en) * | 2013-07-05 | 2016-01-20 | 复旦大学 | A kind of integrated electrochemical sensing chip |
| US11471888B2 (en) | 2015-06-05 | 2022-10-18 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| US11944974B2 (en) | 2015-06-05 | 2024-04-02 | Miroculus Inc. | Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling |
| US11890617B2 (en) | 2015-06-05 | 2024-02-06 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| CN105854117A (en) * | 2016-03-28 | 2016-08-17 | 南京理工大学 | Precise administration infusion device based on electrowetting on dielectric |
| CN105854117B (en) * | 2016-03-28 | 2022-03-15 | 南京理工大学 | Accurate infusion set that doses based on electrowetting on medium |
| US11298700B2 (en) | 2016-08-22 | 2022-04-12 | Miroculus Inc. | Feedback system for parallel droplet control in a digital microfluidic device |
| US11833516B2 (en) | 2016-12-28 | 2023-12-05 | Miroculus Inc. | Digital microfluidic devices and methods |
| US11253860B2 (en) | 2016-12-28 | 2022-02-22 | Miroculus Inc. | Digital microfluidic devices and methods |
| CN110383061A (en) * | 2016-12-28 | 2019-10-25 | 米罗库鲁斯公司 | Digital microcurrent-controlled device and method |
| US11623219B2 (en) | 2017-04-04 | 2023-04-11 | Miroculus Inc. | Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets |
| US11413617B2 (en) | 2017-07-24 | 2022-08-16 | Miroculus Inc. | Digital microfluidics systems and methods with integrated plasma collection device |
| US11857969B2 (en) | 2017-07-24 | 2024-01-02 | Miroculus Inc. | Digital microfluidics systems and methods with integrated plasma collection device |
| US11738345B2 (en) | 2019-04-08 | 2023-08-29 | Miroculus Inc. | Multi-cartridge digital microfluidics apparatuses and methods of use |
| US11524298B2 (en) | 2019-07-25 | 2022-12-13 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
| US11772093B2 (en) | 2022-01-12 | 2023-10-03 | Miroculus Inc. | Methods of mechanical microfluidic manipulation |
| US11857961B2 (en) | 2022-01-12 | 2024-01-02 | Miroculus Inc. | Sequencing by synthesis using mechanical compression |
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