CN102755202B - Animal operation and experiment table - Google Patents
Animal operation and experiment table Download PDFInfo
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- CN102755202B CN102755202B CN201210272208.XA CN201210272208A CN102755202B CN 102755202 B CN102755202 B CN 102755202B CN 201210272208 A CN201210272208 A CN 201210272208A CN 102755202 B CN102755202 B CN 102755202B
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Abstract
The invention discloses an animal operation and experiment table. The animal operation and experiment table comprises a table top of an experiment table, rails and an operation table, wherein the table top of the experiment table is provided with a first imaging hole which passes through the table top of the experiment table; the rails are arranged on the table top of the experiment table so as to fix an imaging device; the operation table is movably arranged on the table top of the experiment table and is provided with a second imaging hole which passes through the operation table; and the first image hole and the second imaging hole are kept coaxial. According to the animal operation and experiment table, the operation table is combined with the imaging device into a whole, the blood flow can be continuously detected in real time before, in or after the process of operation on animals, and the requirements of imaging blood vessels and the blood flow of the experimental animals at different body positions (such as lying on the back or lying on stomach) can be met.
Description
Technical field
The present invention relates to field of biomedicine technology, and in particular to a kind of animal surgery testing stand.
Background technology
Blood flow is biological tissue's supply oxygen and nutrition, and its dynamic variation reflects the state of biological tissue's metabolism and physiological function.Hemodynamic monitoring is that the Diagnosis and Treat of clinical disease provides important information, become clinical in requisite monitoring means.
In the research process of the relevant disease (as apoplexy) of some cerebral tissue, early stage cortex Blood supply mechanism is significant to searching optimal treatment window, therefore monitor the regulation of disease most important to the blood flow of brain in clinical experiment, and optical image technology is as a kind of important Brian Imaging means, be widely used in the research of brain science.At present at blood flow in health check-up is surveyed, laser doppler technique obtains extensive use, but this technology is only suitable for monitoring the flow velocity of single vessel, as monitored the flow velocity of large area region blood vessel, needs to add scanning means, thus limits time or the spatial resolution of imaging; And this method adopts transmission mode to measure vascular flow rate, require higher to the transparency of tissue to be measured.Briers etc. propose a kind of laser speckle imaging technology in recent years, analytical technology is contrasted also referred to as laser speckle, the blood distribution in region can be obtained without the need to scanning, and the method adopts catoptric imaging mode to measure blood flow, to the transparency not requirement of blood vessel, therefore there is purposes widely.
Laser speckle contrast imaging technology (LSCI) can obtain the two-dimensional brain cortex blood-stream image of high time and space resolution, endogenous cytokinin technology (OIS) provides the cerebral function imaging method with higher spatial resolution, by the application of multiple brain imaging technique, we can realize monitoring and the imaging of the cortex blood flow of single or multiple parameter.But utilize the brain blood flow of existing animal clinical surgical experiments platform to animal to monitor, because the Brian Imaging system of laboratory table and optics is separated from each other, therefore in animal surgery process, Real-Time Monitoring cannot be carried out to cerebral blood flow.
In addition, for the feature of optical image technology, laboratory table must ensure the stable of laboratory animal head, and in experiment operation, requires to carry out the fixing of different position (lie on the back/prostrate) to laboratory animal.Brain solid positioner is now mainly prone Position Design, cannot meet the location of dorsal position, if apoplexy modeling operation carries out under dorsal position.And, in experiment operation, require that laboratory table has certain mobility to be convenient to operation technique.The table top of tradition fixed flat planar formula, is not easy to operate target area in operation process.
Summary of the invention
The object of the present invention is to provide a kind of animal surgery laboratory table, to solve the disappearance of prior art.
For solving above technical problem, animal surgery laboratory table provided by the invention, it comprises: laboratory bench top, has the first imaging hole worn on it; Track, is arranged at described laboratory bench top, with fixed imaging device; Operating-table, is movably set on described laboratory bench top, has the second imaging hole worn on it; Described first imaging hole and the second imaging hole keep same axle center.
Further, described laboratory bench top is provided with depressed part.
Further, described operating-table is circular operating-table, and its edge is gear-like.
Further, described animal surgery laboratory table comprises: activity orientation part, is arranged on described laboratory bench top, with the gear-like edge matching of described operating-table.
Further, animal surgery laboratory table comprises: runing rest, and be arranged on described laboratory bench top, described operating-table is fixed on described runing rest.
Further, described runing rest, comprises elevation and subsidence regulating device and regulates fixture.
Further, animal surgery laboratory table comprises: fixture, and be arranged on described operating-table, it comprises: ear bar, position finder.
Further, described position finder, comprises adapter, fixes the head of animal with activity.
Further, described fixture comprises: adjusting device, is connected with described ear bar, to regulate described ear bar.
In sum, animal surgery laboratory table provided by the invention, for laboratory animal head provides noinvasive and stable fixed form.And, achieved the combination of imaging device and laboratory table by slide rail mode, and meet the fixing of different position.In addition, the present invention, using the grown form of circle as experiment porch, adds the motility of operation technique.For guaranteeing its stability rotated, circular platform is fixed in rotatable support frame by we, and is gear-like by edge designs, realizes fixing by the mode of key, thus realizes the flexible rotating of experiment porch and fix.The present invention devises the lowering or hoisting gear of circular operating-table in addition, is used for changing the distance of target object and imaging device.For realizing carrying out monitored over time to whole modeling operation process, imaging device moves to immediately below Surgery Platform by the present invention, by imaging hole, imaging is carried out to laboratory animal head, thus the operation interference broken away from operation process, reach the object of laboratory animal cerebral blood flow change in monitored over time operation.
Accompanying drawing explanation
Figure 1 shows that the structural representation of the animal surgery laboratory table that one embodiment of the invention provides;
Figure 2 shows that the close-up schematic view of the animal surgery laboratory table that one embodiment of the invention provides;
Figure 3 shows that the structural representation of the runing rest of the animal surgery laboratory table that one embodiment of the invention provides;
Figure 4 shows that the structural representation of the animal fixing device of the animal surgery laboratory table that one embodiment of the invention provides.
Detailed description of the invention
For making object of the present invention, feature becomes apparent, and is further described the specific embodiment of the present invention below in conjunction with accompanying drawing.
Refer to Fig. 1, refer to Fig. 1, Figure 1 shows that the structural representation of the animal surgery laboratory table that one embodiment of the invention provides.
This animal surgery laboratory table, for animal head operation, it comprises: laboratory bench top 110, has the first imaging hole 111 worn on it; Track 120, is arranged at described laboratory bench top 110, with fixed imaging device 130; Operating-table 140, is movably set on described laboratory bench top 110, has the second imaging hole 141 worn on it; Described first imaging hole 111 and the second imaging hole 141 keep same axle center.
In the present embodiment, track 120 wedge track for this reason, and be arranged at above or below described laboratory bench top 110 or both up and down.Imaging device 130 to be fixed on described track 120 and can to slide on track 120 and regulates.Thus make the first imaging hole 111 in the camera lens of imaging device 130 and animal surgery laboratory table and the second imaging hole 141 keep an axis, thus ensure that the accuracy of observation.
In an embodiment of the present invention, in order to realize carrying out monitored over time to whole modeling operation process, because track 120 is arranged at above or below described laboratory bench top 110 or both up and down, imaging device 130 is fixed on below laboratory bench top 110 by the present embodiment, by the first imaging hole 111 and the second imaging hole 141 pairs of laboratory animals, such as rat head carries out imaging, thus the operation interference broken away from operation process, reach the object of laboratory animal cerebral blood flow change in monitored over time modeling operation.
In embodiments of the present invention, laboratory bench top 110 is provided with depressed part 160, places computer 170 for user, and the USB line that computer 170 is connected with imaging device 130 is built in laboratory table, only two need be inserted respectively computer and imaging device 1, handled easily when needing.
In embodiments of the present invention, refer to Fig. 2, in order to increase the motility of operation technique, described operating-table 140 is circular operating-table, and its edge is gear-like.This animal surgery laboratory table comprises keeper 150, is arranged on described laboratory bench top 110, with the gear-like edge matching of described operating-table 140.Conflicted by the engaging at keeper 150 pairs of operating-table 140 gear-like edges, reach the effect of fixing operation platform 140.In the present embodiment, keeper 150, for pressing the location button of upspringing, is upspring by this button and to be engaged with the gear-like edge of described operating-table 140, thus realize the location of described operating-table 140.
In embodiments of the present invention, refer to Fig. 3, it is depicted as the structural representation of the runing rest of the animal surgery laboratory table that one embodiment of the invention provides, add operation technique motility and guarantee operate stability, described laboratory bench top 110 arranges runing rest 170, operating-table 140 is fixed on described runing rest 170, thus realize the flexible rotating of operating-table 140, and in conjunction with the gear-like edge matching of above-mentioned keeper 150 with described operating-table 140, and then achieve the stable fixing of operating-table 140.
In embodiments of the present invention, described runing rest 170, comprise elevation and subsidence regulating device 171 and regulate fixture 172, the height of operating-table 140 is regulated by elevation and subsidence regulating device 171, and then be adjusted to the distance of picture target area to imaging device 130 camera lens, and by regulating fixture 172, adopt adjusting screw(rod) threaded adjusting in the present embodiment, realize the monolithic stability lifting of operating-table 140.
In embodiments of the present invention, refer to Fig. 4, it is depicted as the structural representation of the animal fixing device of the animal surgery laboratory table that one embodiment of the invention provides.
This fixture 400, be arranged on described operating-table 140, it comprises: ear bar 411,412, position finder 420.Described position finder 420, comprises adapter 421, fixes the head of animal with activity.
Fixture 400 comprises: adjusting device 431,432, is connected with described ear bar 411,412, to regulate described ear bar 411,412.
In the present embodiment, have two ear bars 411 and 412 for loading test animal, as rat, ear fixes its head, ear bar 411 and 412 is secured to the adjusting device 431 and 432 in figure respectively by screw tightening, and the degree of depth that ear bar 411 and 412 inserts rat ear can regulate.
Refer to Fig. 4, position finder 420, comprise adapter 421, fix the head of animal with activity.
Time fixing, position finder 420 can catch on the tooth of experimental rat by fore-aft travel.The adapter 421 be fixed on position finder 420 is stretched in the head front end (i.e. rat nasal portion) of rat, and according to the head form of different rat, rat head can fix to correct position by fore-aft travel by adapter 421.Rat dorsal position or prone fixing can be realized by being overturn by adapter 421.
In sum, the animal surgery laboratory table that the embodiment of the present invention provides, for laboratory animal head provides noinvasive and stable fixed form.And, achieved the combination of imaging device and laboratory table by slide rail mode, and meet the fixing of different position.In addition, the embodiment of the present invention, using the grown form of circle as laboratory table, adds the motility of operation technique.For guaranteeing its stability rotated, laboratory table is fixed in rotatable support frame by we, and is gear-like by edge designs, realizes fixing by the mode of button, thus realizes the flexible rotating of experiment porch and fix.Embodiments provide the lowering or hoisting gear of circular operating-table in addition, be used for changing the distance of target object and imaging device.For realizing carrying out monitored over time to whole modeling operation process, imaging device moves to immediately below Surgery Platform by the present invention, by imaging hole, imaging is carried out to laboratory animal head, thus the operation interference broken away from operation process, reach the object of laboratory animal cerebral blood flow change in monitored over time operation.
These are only citing, and be not used to limit the present invention, the scope that protection scope of the present invention should contain with claims is as the criterion.
Claims (9)
1. an animal surgery laboratory table, is characterized in that, comprising:
Laboratory bench top, has the first imaging hole worn on it;
Track, is arranged at described laboratory bench top, with fixed imaging device; Fixing also can the slip in orbit on the track of described imaging device regulates;
Operating-table, is movably set on described laboratory bench top, has the second imaging hole worn on it;
Described first imaging hole and the second imaging hole keep same axle center.
2. animal surgery laboratory table according to claim 1, is characterized in that, described laboratory bench top is provided with depressed part.
3. animal surgery laboratory table according to claim 1, is characterized in that, described operating-table is circular operating-table, and its edge is gear-like.
4. animal surgery laboratory table according to claim 3, is characterized in that, also comprise:
Activity orientation part, is arranged on described laboratory bench top, with the gear-like edge matching of described operating-table.
5. animal surgery laboratory table according to claim 1, is characterized in that, also comprise:
Runing rest, be arranged on described laboratory bench top, described operating-table is fixed on described runing rest.
6. animal surgery laboratory table according to claim 5, is characterized in that, described runing rest comprises elevation and subsidence regulating device and regulates fixture.
7. animal surgery laboratory table according to claim 1, is characterized in that, also comprise:
Fixture, it comprises ear bar and position finder, is arranged on described operating-table.
8. animal surgery laboratory table according to claim 7, is characterized in that, described position finder comprises adapter, fixes the head of animal with activity.
9. animal surgery laboratory table according to claim 7, is characterized in that, described fixture comprises adjusting device, and described adjusting device is connected with described ear bar, to regulate described ear bar.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210272208.XA CN102755202B (en) | 2012-08-02 | 2012-08-02 | Animal operation and experiment table |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210272208.XA CN102755202B (en) | 2012-08-02 | 2012-08-02 | Animal operation and experiment table |
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| CN102755202A CN102755202A (en) | 2012-10-31 |
| CN102755202B true CN102755202B (en) | 2015-01-07 |
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| CN201210272208.XA Expired - Fee Related CN102755202B (en) | 2012-08-02 | 2012-08-02 | Animal operation and experiment table |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018136681A1 (en) * | 2017-01-20 | 2018-07-26 | Regeneron Pharmaceuticals, Inc. | Rotatable surgical table |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546209B (en) * | 2013-10-18 | 2017-03-15 | 苏州瑞派宁科技有限公司 | A kind of toy position finder |
| CN107049549B (en) * | 2017-05-31 | 2019-04-09 | 杭州高能医疗设备有限公司 | The Machinery Control System of imaging |
| CN108030568B (en) * | 2018-01-23 | 2019-11-29 | 佳木斯大学 | A kind of medical research animal experimental table |
| CN108836557B (en) * | 2018-07-04 | 2021-03-23 | 十堰市太和医院 | Adaptation device for fixing rat or mouse through oral cavity |
| CN108904092B (en) * | 2018-07-17 | 2020-02-07 | 新乡医学院三全学院 | Experiment table for white mouse anatomy experiment teaching |
| CN109044558A (en) * | 2018-08-24 | 2018-12-21 | 中国人民解放军总医院 | A kind of 3 D positioning equipment for Bioexperiment |
| CN109124811A (en) * | 2018-09-28 | 2019-01-04 | 遵义医学院附属医院 | A kind of medical experiment rat fixed station |
| CN111888036B (en) * | 2020-07-31 | 2022-04-26 | 福建医科大学附属第一医院 | Fixing structure of rat brain stereotaxic instrument |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624437A (en) * | 1995-03-28 | 1997-04-29 | Freeman; Jerre M. | High resolution, high speed, programmable laser beam modulating apparatus for microsurgery |
| JPH11197148A (en) * | 1997-10-24 | 1999-07-27 | Morita Mfg Co Ltd | Auxiliary device radiography and x-ray bisection plane photographing method using the same |
| JP2002136511A (en) * | 2000-10-31 | 2002-05-14 | Shimadzu Corp | X-ray imaging device |
| US6491699B1 (en) * | 1999-04-20 | 2002-12-10 | Surgical Navigation Technologies, Inc. | Instrument guidance method and system for image guided surgery |
| CN1938626A (en) * | 2004-03-31 | 2007-03-28 | 奥林巴斯株式会社 | Observing device and fluorescent light observing device |
| CN101697871A (en) * | 2009-11-16 | 2010-04-28 | 华中科技大学 | Laser imaging method and device for automatically cutting artery blood vessel and vein blood vessel |
| CN101919686A (en) * | 2010-09-21 | 2010-12-22 | 华中科技大学 | Multi-mode imaging system for observing cerebral cortex functions of moving animals |
| CN101926644A (en) * | 2010-09-21 | 2010-12-29 | 华中科技大学 | Cortical functional multi-mode imaging system |
| CN102065769A (en) * | 2008-06-13 | 2011-05-18 | 卡尔斯特里姆保健公司 | Torsional support for craniocaudal rotation of animals |
| CN102596019A (en) * | 2009-09-04 | 2012-07-18 | 约翰斯·霍普金斯大学 | Multimodal laser speckle imaging |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080234586A1 (en) * | 2007-03-19 | 2008-09-25 | The General Hospital Corporation | System and method for providing noninvasive diagnosis of compartment syndrome using exemplary laser speckle imaging procedure |
-
2012
- 2012-08-02 CN CN201210272208.XA patent/CN102755202B/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624437A (en) * | 1995-03-28 | 1997-04-29 | Freeman; Jerre M. | High resolution, high speed, programmable laser beam modulating apparatus for microsurgery |
| JPH11197148A (en) * | 1997-10-24 | 1999-07-27 | Morita Mfg Co Ltd | Auxiliary device radiography and x-ray bisection plane photographing method using the same |
| US6491699B1 (en) * | 1999-04-20 | 2002-12-10 | Surgical Navigation Technologies, Inc. | Instrument guidance method and system for image guided surgery |
| JP2002136511A (en) * | 2000-10-31 | 2002-05-14 | Shimadzu Corp | X-ray imaging device |
| CN1938626A (en) * | 2004-03-31 | 2007-03-28 | 奥林巴斯株式会社 | Observing device and fluorescent light observing device |
| CN102065769A (en) * | 2008-06-13 | 2011-05-18 | 卡尔斯特里姆保健公司 | Torsional support for craniocaudal rotation of animals |
| CN102596019A (en) * | 2009-09-04 | 2012-07-18 | 约翰斯·霍普金斯大学 | Multimodal laser speckle imaging |
| CN101697871A (en) * | 2009-11-16 | 2010-04-28 | 华中科技大学 | Laser imaging method and device for automatically cutting artery blood vessel and vein blood vessel |
| CN101919686A (en) * | 2010-09-21 | 2010-12-22 | 华中科技大学 | Multi-mode imaging system for observing cerebral cortex functions of moving animals |
| CN101926644A (en) * | 2010-09-21 | 2010-12-29 | 华中科技大学 | Cortical functional multi-mode imaging system |
Non-Patent Citations (5)
| Title |
|---|
| "Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery:a pilot clinical study";Parthasarathy,et al;《Journal of Biomedical Optics》;20101130;第15卷(第6期);第066030-1－066030-8页 * |
| "Simultaneous bilateral laser Doppler fluxmetry and electrophysiological recording during middle cerebral artery occlusion in rats";Edwin, et al;《Journal of Neuroscience Methods》;20060630;第154卷(第1－2期);第109－115页 * |
| "基于激光散斑成像的小鼠脑出血后大脑皮层血流时空变化的研究";刘晨玮;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20110715;E070-20 * |
| "监测区域性流速分布的激光散斑成像系统 ";程海英 等;《仪器仪表学报》;20040615;第25卷(第3期);第409－412页 * |
| "高分辫率激光散斑血流成像技术及其应用";苗鹏;《中国博士学位论文全文数据库 信息科技辑 》;20120715;I138-94 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018136681A1 (en) * | 2017-01-20 | 2018-07-26 | Regeneron Pharmaceuticals, Inc. | Rotatable surgical table |
| US11864976B2 (en) | 2017-01-20 | 2024-01-09 | Regeneron Pharmaceuticals, Inc. | Rotatable surgical table |
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