CN102375071A - Method for testing parameters of biological samples - Google Patents
Method for testing parameters of biological samples Download PDFInfo
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- CN102375071A CN102375071A CN201110281191XA CN201110281191A CN102375071A CN 102375071 A CN102375071 A CN 102375071A CN 201110281191X A CN201110281191X A CN 201110281191XA CN 201110281191 A CN201110281191 A CN 201110281191A CN 102375071 A CN102375071 A CN 102375071A
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Abstract
The invention provides a method for testing parameters of biological samples. The method is characterized by comprising the following steps; 1) turning on a power supply, starting up a biochemical analyzer for power-on self-testing; 2) after passing through the power-on self-testing, preheating the biochemical; 3) when the testing temperature of the biochemical analyzer meets a preset temperature condition, reminding of putting test components and test samples; 4) testing in the biochemical analyzer; 5) after the testing is completed, outputting a testing result; 6) reminding of taking out the used test components and test samples; 7) reminding whether the testing is completed; 8) if selecting that the testing is not completed, reminding of putting new test components and test samples, then repeating the steps 4)-6); and 9) if selecting that the testing is completed, powering off the biochemical analyzer, and completing the testing. The testing system disclosed by the invention can smoothly complete testing, and provide accurate testing results.
Description
Technical field
The present invention relates to a kind of method of testing that adopts Biochemical Analyzer to measure the biological specimen parameter.
Background technology
Along with progress of science and technology, the bedside in-vitro diagnosis experiment (POCT:Point of Care Testing) in the laboratory medicine field is arisen at the historic moment and is obtained fast development.20th century, " soak and read " dry chemical method (dip-and-read) of occurring of the fifties was meant that liquid is detected sample directly to be added on the business-like dry type reagent strip into the disparity items certain production; Moisture with tested sample causes specific chemical reaction as solvent, thereby carries out chemico-analytic method.Biochemical dry type test paper method receives people's attention with characteristics such as its finding speed easy to carry, simple to operate are fast, also plays a significant role in the fast detecting at the scene.Introduction along with immune response and molecular biotechnology; The check field of medical science dry type test paper method expands to the detection to blood sugar, gestation, blood coagulable status, myocardial damage, acid base equilibrium, infectious diseases etc., and analysis, the infectious disease of medicine concentration monitor (TMD), alcohol content detection, thrombotest, blood mesophytization index are sieved, hormonal readiness and microchip DNA diagnosis and drug abuse detection etc. during operation.Rely on ocular estimate to judge the testing result of dry chemistry test paper slip, can only be as qualitative judgement, artificial subjective factor is very big to the decision influence of testing result, is easy to cause erroneous judgement.Therefore for to make the interpretation of quick detection test paper more accurate, supporting with it miniaturization experimental apparatus progressively grows up.These easy and simple to handleization of detecting instrument, result report timelyization, accuracy, more and more receive clinical medical and nursing personnel, patient and family members' thereof favor.And the resulting data of these detecting instruments can also realize that remote-wireless transfers to laboratory computer management system or electronic health record.
U.S. Pat 4780283 has disclosed a kind of dry chemical test paper analyser.This analyser comprises fixed detection light source, loads the hemispherical workbench of test paper bar.Through the interaction between the spring hemispherical workbench being transported to the detection light source place detects.Owing to just utilized the mechanicals efforts between the spring; Not only on producing, require to have very accurately control procedure; Increase production cost, and utilized the interaction of spring to be difficult to the tram between control reaction reagent bar and the detection light source, influenced testing result.And hemispherical structure has increased the volume of whole analytical instrument.On the other hand, spring is short serviceable life, needs regular replacing spring, and this makes troubles for the user of instrument.
U.S. Praxsys Biosystems Inc. company has developed a kind of tachysynthesis detection system that can be used for qualitative and quantitative judgement, in U.S. Pat 6136610, discloses, and this system is made up of detector and supporting with it detection paper box.This system uses single channel, promptly once only can detect single patient's sample.Because this detecting instrument once can only detect an index, so detection efficiency is lower.
One Chinese patent application 200910160639.5 discloses a kind of multi-channel portable colloidal gold test paper device for quick testing, mainly comprises: 4 independently sense channel, ARM data processor, keyboard and LCD parts.The pick-up unit of this invention can the multiple test item of quick and high-throughout completion.But 4 of this one Chinese patent application independently sense channel and whole detector be an integral body, the instrument user can not arbitrarily change test event through changing sense channel.
One Chinese patent application 200410052202.7 discloses a kind of quick diagnosis lateral flow assays system and method; This detection system comprises 1 master unit and 1 to 20 test module; And being connected to host computer through USB or blue teeth wireless receiver, host computer moves through the software control detector.This patented claim also discloses and has been designed to relatively independent relation between master unit and the test module, and when master unit broke down, all proving installations can be removed and ressemble with another master unit.It is a very complicated process that the described test module of this patented claim disassembles from master unit, needs a lot of parts of breakdown.On the other hand; Described test module is not the structure of a sealing; When sample when retention in the test module that is removed has test or test agent; Sample that these are residual or reagent can be exposed in the environment, and the environment around not only having polluted also can constitute dangerous to operating personnel's life security.
Summary of the invention
In order to overcome above-mentioned shortcoming of the prior art, one of the object of the invention provides the proving installation that a kind of medical test is used.
1, the proving installation used of a kind of medical test; It is characterized in that: comprise that base 101, design transport the movably microscope carrier 102 of testing element and be positioned at movably light emitted and the receiving trap 103 above the microscope carrier 102 in being used on the base 101; Microscope carrier 102 can move back and forth at predefined track; Light emitted and receiving trap 103 can near with away from microscope carrier 102, the motion track of microscope carrier 102 and light emitted and receiving trap 103 or the extended line of motion track intersect the perhaps orthogonal projection in same plane each other and intersect each other in same plane.
2, according to 1 described proving installation; It is characterized in that: when certain FX on the microscope carrier 102 is positioned at orthogonal projection place of light emitted and receiving trap 103 just; Microscope carrier 102 stops to move; Light emitted and receiving trap 103 detect near that FX on the microscope carrier 102 then, after detect accomplishing again away from that FX on the microscope carrier 102.
3, according to 2 described proving installations, it is characterized in that: proving installation also comprises the support 104 of at least one Fixed Design on base 101, and said light emitted and receiving trap 103 designs are on said support 104.
4, according to 3 described proving installations, it is characterized in that: said proving installation comprises at least two motors, drives said microscope carrier 102 and light emitted and receiving trap 103 respectively.
5, according to 4 described proving installations, it is characterized in that: said electro-motor is a stepper motor 107,130.
6, according to 5 described proving installations; It is characterized in that: on microscope carrier 102, be fixed with rack-plate 111; The stepper motor 107 that has gear 108 is installed on the said support, and the gear 108 on the stepper motor is connected with a joggle with the rack-plate 111 on the microscope carrier 102, drives microscope carrier 102 and moves.
7, according to 3 described proving installations, it is characterized in that: on base 101, be designed with left socle 104, right support 105, on said left socle and right support, be designed with upper bracket 106, light emitted and receiving trap 103 designs are on upper bracket 106.
8, according to 1 described proving installation, it is characterized in that: light emitted and receiving trap 103 comprise the optical coupled switch 132 that light emitted device 131, optical pickup apparatus and control light emitted and receiving trap move.
9, according to 8 described proving installations; It is characterized in that: said smooth lotus root switch 132 has lightening hole 133; Have shutter 134 on light emitted and the receiving trap, said shutter 134 has the lightening hole of blocking 133 and leaves 133 two positions of lightening hole with respect to lightening hole 133.
10, according to 9 described proving installations; It is characterized in that: in light emitted and the receiving trap 103 downward operational processs, when shutter 134 is positioned at lightening hole 133 tops of light lotus root switch 132, this moment, light path was unimpeded; Power supply keeps power supply state always; Make light emitted device 131 under electro-motor 130 rotates, continue to move downward, when shutter 134 had stopped the lightening hole 133 of light lotus root switch 132, light path was cut off; Thereby close the power supply of the electro-motor 130 of light emitted and receiving trap 103, and open light emitted and receiving trap 103 carries out the analysis of sample.
11, according to any one described proving installation of 1-10, it is characterized in that: base 101 Fixed Design have track base 112, and microscope carrier 104 Fixed Design have guide rail 113, said guide rail 113 and track base 112 sliding combination.
Two of the object of the invention provides a kind of medical detecting analyzer.
12, a kind of medical detecting analyzer; It is characterized in that: comprise a master control set 10 and at least one proving installation 100; Wherein, Master control set 10 comprises supply unit 11, control device, testing result output unit and is no less than the storage chamber 15 of proving installation number; Proving installation 100 comprises the microscope carrier 102 and the light emitted and the receiving trap 103 that are positioned at microscope carrier 102 tops that is used to carry detecting element and detection sample; Proving installation 100 is placed in the storage chamber 15 of master control set and with supply unit 11, control device and the testing result output unit of master control set and is electrically connected, and the microscope carrier 102 of control device control proving installation moves back and forth in certain direction, light emitted and receiving trap 103 with the direction of microscope carrier 102 moving direction approximate vertical on work mobile near with away from microscope carrier; And detect the change color parameter that places the detecting element on the microscope carrier 102; Then this parameter is delivered to control device, after handling through control device, via testing result output unit output testing result.
13, according to 12 described medical detecting analyzers, it is characterized in that: master control device 10 extracted and organized to proving installation 100 can repeated multiple times out.
14, according to 13 described medical detecting analyzers, it is characterized in that: be designed with rail structure between the inwall of the storage chamber 15 of the outer wall of proving installation 100 and master control set 10.
15, according to 14 described medical detecting analyzers, it is characterized in that: rail structure comprises the guide rail 16 and slide block structure 120 that is placed on storage chamber 15 inwalls and the proving installation outer wall, and said slide block structure 120 can slide in the guide rail 16 of storage chamber 15.
16, according to any one described medical detecting analyzer of 12-15; It is characterized in that: the proving installation 100 that comprises two or more; Each proving installation can detect the identical or different parameter that detects sample with kind, also can detect the identical or different parameter that variety classes detects sample.
17, according to 15 described medical detecting analyzers, it is characterized in that: also comprise at least one reagent storage unit 18, can place the plurality of detection element in this reagent storage unit 18.
18, according to 17 described medical detecting analyzers; It is characterized in that: the storage chamber 15 in the master control set 10 is optionally accommodated proving installation 100 or reagent storage unit 18; Be that storage chamber 15 can not only be taken in proving installation 100, also can take in reagent storage unit 18.
19, according to any one described medical detecting analyzer of 12-15 and 17-18, it is characterized in that: wherein the testing result output unit comprises printer 14 and/or display 13.
20, according to any one described medical detecting analyzer of 12-15 and 17-18, it is characterized in that: wherein control device comprises touch-screen display 13, and this touch-screen display 13 provides operation interface.
21, according to any one described medical detecting analyzer of 12-15 and 17-18, it is characterized in that: also comprise the latching system of master control set 10 with proving installation 100 snap closes or release.
22, according to 21 described medical detecting analyzers; It is characterized in that: said latching system comprises three permanent magnet blocks; Wherein first and second magnetic patch are placed in the shell of master control set 10, and the 3rd magnetic patch is fixed on the shell of proving installation 100, when proving installation is housed in the storage chamber 15 of master control set fully; Three magnetic patch are arranged in straight line basically; Second magnetic patch is between the first and the 3rd magnetic patch, and the two relative utmost point magnetic of the second and the 3rd magnetic patch are (for example one is the S utmost point, and another is the N utmost point) on the contrary; First two utmost point magnetic identical (for example all being the N utmost point or the S utmost point) that magnetic patch is relative with second magnetic patch, first magnetic patch can move with the line of proving installation (100) along three magnetic patch.
Three of the object of the invention provides a kind of Biochemical Analyzer.
23, a kind of Biochemical Analyzer; It is characterized in that: comprise a master control set 10 and at least one proving installation 100, master control set 10 comprises at least one storage chamber 15, and proving installation 100 is incorporated in the said storage chamber 15; Be designed with guide rail 16 in the storage chamber 15; Proving installation 100 is designed with slide block structure, and said slide block structure can slide in the guide rail 16 of storage chamber 15, thus reposefully with proving installation 100 from shifting out in the storage chamber 15 or proving installation being gone in storage chamber 15 for 100 groups.
24, according to 23 described Biochemical Analyzers, it is characterized in that: the two side of storage chamber 15 is designed with guide rail 16 respectively, and perhaps the bottom design at storage chamber has guide rail 17, perhaps all is designed with guide rail in the two side and the bottom of storage chamber.
25, according to 24 described Biochemical Analyzers, it is characterized in that: said slide block structure comprises the take-up housing 120 that designs in the side of proving installation base 101, in take-up housing 120, is provided with slide block 121, and said slide block 121 can slide in the guide rail 16 of storage chamber 15.
26, according to 24 described Biochemical Analyzers, it is characterized in that: said slide block structure comprises the take-up housing 120 that designs in the bottom of proving installation base 101, in take-up housing 120, is provided with slide block 121, and said slide block 121 can move in the guide rail 17 of storage chamber 15.
27, according to 23 described Biochemical Analyzers, it is characterized in that: the proving installation 100 that comprises two or more and quantity are no less than the storage chamber 15 of proving installation number.
28, according to 27 described Biochemical Analyzers, it is characterized in that: be separate work between the described proving installation 100.
29, according to 23 described Biochemical Analyzers, it is characterized in that: also comprise at least one reagent storage unit 18, have at least a storage chamber 15 to be used to take in reagent storage unit 18, remaining storage chamber is used to take in proving installation 100.
30, according to 29 described Biochemical Analyzers, it is characterized in that: described reagent storage has reagent storage frame 19 in the unit.
31, according to any one described Biochemical Analyzer of 23 to 30, it is characterized in that: fasten each other through the magnetic patch buckle structure between described proving installation 100 or reagent storage frame 19 and the master control set 10.
32, according to 31 described Biochemical Analyzers; It is characterized in that: described magnetic patch buckle structure comprises three permanent magnet blocks; Wherein first magnetic patch 151 and second magnetic patch 152 are placed in the shell of master control set 10, and the 3rd magnetic patch 153 is fixed on the shell of proving installation 100, when proving installation is housed in the storage chamber 15 of master control set fully; Three magnetic patch are arranged in straight line basically; Second magnetic patch 152 is between first magnetic patch 151 and the 3rd magnetic patch 153, and the two relative utmost point magnetic of second magnetic patch 152 and the 3rd magnetic patch 153 are (for example one is the S utmost point, and another is the N utmost point) on the contrary; Two utmost point magnetic identical (for example all being the N utmost point or the S utmost point) that first magnetic patch 151 is relative with second magnetic patch 152, first magnetic patch 151 can move along the line of three magnetic patch.
33, according to 32 described Biochemical Analyzers; It is characterized in that: 151 designs of first magnetic patch are on proving installation backboard 126; 152 designs of second magnet piece are in master control set 10; On the master control set bonnet, being designed with two bracing frames, 154, the three magnetic patch 153 is connected with bracing frame 154 through spring leaf 155.
34, according to 23 described Biochemical Analyzers, it is characterized in that: master control set 10 also comprises primary power 11, master switch 12, guidance panel 13 and printer 14, and master switch 12, guidance panel 13 and printer 14 are electrically connected with primary power 11.
35, according to 23 described Biochemical Analyzers, it is characterized in that: master control set 10 also comprises usb 19, fan 20 and general supply access port 21.
36, according to 23 described Biochemical Analyzers, it is characterized in that: proving installation 100 comprises a base 101, the microscope carrier that transport test strip 102 of design on base 101; Be positioned at the light emitted and the receiving trap 103 of microscope carrier 102 tops; At least Fixed Design has a support on base 101, and 103 designs of said light emitted and receiving trap are designed with rack-plate 111 at least one side of microscope carrier 102 regularly on said support; On said support, be designed with stepper motor 107; Gear 108 on the stepper motor is connected with a joggle with the rack-plate 111 on the microscope carrier 102, and the stepper motor driven gear rotates, and the gear driven microscope carrier moves in proving installation.
37, according to 36 described Biochemical Analyzers, it is characterized in that: said light emitted and receiving trap 103 comprise and promote motor 130, light emitted device 131, optical pickup apparatus and control light emitted that light emitted device 131 moves up and down and the optical coupled switch 132 of receiving trap movement position.
38, according to 23 described Biochemical Analyzers, it is characterized in that: said master control set 10 and proving installation 100 electric connections.
39, according to 38 described Biochemical Analyzers, it is characterized in that: master control set 10 is connected through power connector 140 with proving installation 100.
Four of the object of the invention provides another kind of Biochemical Analyzer.
40, a kind of Biochemical Analyzer; Comprise master control set 10 and the proving installation 100 that is electrically connected with master control set 10; It is characterized in that: master control set 10 comprises supply unit 11 and control device, proving installation 100 comprise microscope carrier movably 102 be positioned at can do on the microscope carrier near and the light emitted and the receiving trap 103 that move away from microscope carrier.
41, according to 40 described Biochemical Analyzers, it is characterized in that: said control device comprises shell with master control set 10 by hinged guidance panel 13, and guidance panel 13 can be rotating shaft upset 0-180 degree with the hinge.
42, according to 41 described Biochemical Analyzers, it is characterized in that: the operation interface of said guidance panel 13 is downward, and when guidance panel 13 is rotating shaft upset 90-180 when spending with the hinge, its guidance panel 13 is in opening.
43, according to 41 described Biochemical Analyzers, it is characterized in that: the operation interface of said guidance panel 13 upwards, when guidance panel 13 is rotating shaft upset 0-90 when spending with the hinge, its guidance panel 13 is in opening.
44, according to 43 described Biochemical Analyzers; It is characterized in that: guidance panel 13 is provided with support 24; The two ends of support 24 make the shell of guidance panel 13 and master control set 10 keep the angle between between the 0-90 degree respectively against the shell of guidance panel 13 and master control set 10.
45, according to any one described Biochemical Analyzer of 40-44, it is characterized in that: described guidance panel 13 is LCD or LED display panel.
46, according to 45 described Biochemical Analyzers, it is characterized in that: described guidance panel 13 is the touch-screen LCD or the LED display panels that can carry out touch screen operation.
47, according to any one described Biochemical Analyzer of 40-44, it is characterized in that: be provided with storage chamber 15 in the master control set 10, proving installation 100 inserts storage chamber with the mode of drawer or from storage chamber, extracts out.
48, according to 47 described Biochemical Analyzers, it is characterized in that: the outer wall of the inwall of storage chamber 15 and proving installation 100 is provided with the railroad that cooperatively interacts.
49, according to 48 described Biochemical Analyzers, it is characterized in that: rail structure comprises guide rail 16 and slide block structure 120, and said slide block structure can move on guide rail.
Five of the object of the invention provides a kind of magnetic patch buckle structure.
50, a kind of magnetic patch buckle structure; Comprise at least three permanent magnet blocks, wherein first magnetic patch 151 is fixed on first device, and second magnetic patch 152 is fixed on second device; The 3rd magnetic patch 153 is placed on second device movably; When first and second devices be in each other near the position time, three magnetic patch are arranged in straight line basically, second magnetic patch 152 is between first magnetic patch 151 and the 3rd magnetic patch 153; The two relative utmost point magnetic of second magnetic patch 152 and the 3rd magnetic patch 153 identical (for example all being the N utmost point or the S utmost point); Two utmost point magnetic different (for example one is the S utmost point, and another is the N utmost point) that first magnetic patch 151 is relative with second magnetic patch 152, the 3rd magnetic patch 153 can move along the line of three magnetic patch.
51, according to 50 described magnetic patch buckle structures, it is characterized in that: be designed with the spring leaf 155 that two supports 154 and two ends are movably attached to support 154 on second device, said the 3rd magnetic patch 153 is fixedly connected with spring leaf 155.
52, according to 50 described magnetic patch buckle structures, it is characterized in that: be designed with two slide bars 156 on second device and can on slide bar 156, slide through slide bar button 157 with slide bar button 157, the three magnetic patch 153 that are enclosed within on the slide bar 156.
53, according to 50 described magnetic patch buckle structures, it is characterized in that: be designed with two springs, 158, the three magnetic patch 153 on second device and link to each other with spring 158 through snak link 159.
Six of the object of the invention provides a kind of magnetic patch buckle structure that utilizes and makes two devices mutual snap closes and the method for separating.
54, a kind of magnetic patch buckle structure that utilizes makes two devices mutual snap closes and the method for separating; Said magnetic patch buckle structure comprises at least three permanent magnet blocks; Wherein first magnetic patch 151 is fixed on first device; Second magnetic patch 152 is fixed on second device, and the 3rd magnetic patch 153 is placed on second device movably, when first and second devices be in mutual near the position time; Three magnetic patch are arranged in straight line basically; Second magnetic patch 152 between first magnetic patch 151 and the 3rd magnetic patch 153, the two relative utmost point magnetic of second magnetic patch 152 and the 3rd magnetic patch 153 identical (for example all being the N utmost point or the S utmost point), two utmost point magnetic that first magnetic patch 151 is relative with second magnetic patch 152 are different, and (for example one is the S utmost point; Another is the N utmost point); The 3rd magnetic patch 153 can move along the line of three magnetic patch, and said method comprises the steps: 1) first device that will be fixed with said first magnetic patch 151 to second device that is fixed with said second magnetic patch 152 near, and make said the 3rd magnetic patch 153 and said second magnetic patch 152 keep distance enough far away; First magnetic patch 151 and second magnetic patch 152 are attached together through magnetic force, thereby first device is installed mutual snap close with second; 2) promote the 3rd magnetic patch 153 to second magnetic patch 152 near; Mutual repulsive force between the 3rd magnetic patch 153 and second magnetic patch 152 and first magnetic patch 151; Weaken the magnetic attraction between first magnetic patch 151 and second magnetic patch 153, thereby first device and second device are separated from each other.
Seven of the object of the invention provides a kind of Biochemical Analyzer with magnetic patch buckle structure.
55, a kind of Biochemical Analyzer with magnetic patch buckle structure comprises master control set 10 and proving installation 100, is provided with storage chamber 15 in the master control set 10; Proving installation 100 is housed in the storage chamber 15; It is characterized in that: said magnetic patch buckle structure comprises at least three permanent magnet blocks, and wherein first magnetic patch 151 is fixed on the proving installation 100, and second magnetic patch 152 is fixed on the master control set 10; The 3rd magnetic patch 153 is placed on the master control set 10 movably; When master control set 10 and trial assembly put 100 be in each other near the position time, three magnetic patch are arranged in straight line basically, second magnetic patch 152 is between first magnetic patch 151 and the 3rd magnetic patch 153; The two relative utmost point magnetic of second magnetic patch 152 and the 3rd magnetic patch 153 identical (for example all being the N utmost point or the S utmost point); Two utmost point magnetic different (for example one is the S utmost point, and another is the N utmost point) that first magnetic patch 151 is relative with second magnetic patch 152, the 3rd magnetic patch 153 can move along the line of three magnetic patch.
56, according to 55 described Biochemical Analyzers, it is characterized in that: on master control set 10, be designed with two bracing frames 154) the 3rd magnetic patch 153 is connected with bracing frame 154 through spring leaf 155.
57, according to 55 described Biochemical Analyzers, it is characterized in that: being designed with two slide bars, 156, the three magnetic patch 153 on the master control set 10 can slide on slide bar 156 through slide bar button 157.
58, according to 55 described Biochemical Analyzers, it is characterized in that: be designed with two springs, 158, the three magnetic patch 153 on the master control set 10 and conflict each other through snak link 159 and spring 158.
Eight of the object of the invention provides a kind of method of testing that adopts Biochemical Analyzer to measure the biological specimen parameter.
59, a kind of method of testing that adopts Biochemical Analyzer to measure the biological specimen parameter is characterized in that: may further comprise the steps: 1) opening power, and the Biochemical Analyzer start also gets into the startup self-detection step; 2) after startup self-detection was passed through, Biochemical Analyzer got into preheating step; 3) when the probe temperature of Biochemical Analyzer satisfies predefined temperature conditions, prompting is put into testing element and is detected sample; 4) Biochemical Analyzer starts test; 5) after test is accomplished, output test result; 6) prompting is taken out used testing element and is detected sample; 7) whether prompting detects and finishes; 8) if select not finish, then prompting is put into new testing element and is detected sample, and repeating step 4 then)-6); 9) if select to finish, then shutdown finishes test.
60, according to 59 described method of testings, it is characterized in that: said Biochemical Analyzer comprises master control set 10 and at least one proving installation 100, and the startup self-detection step comprises whether the state of checking each equipment is normal, and the quantity of checkout device 100.
61, according to 60 described method of testings; It is characterized in that: when the quantity of proving installation 100 is equal to, or greater than two; After the step that startup self-detection is passed through, before the preheating step, also comprise and select to open the step that which platform or which platform proving installation 100 are tested.
62, according to 61 described method of testings, it is characterized in that: after having selected the step that proving installation 100 tests or behind the preheating step, also comprise the step that 100 test approaches that will carry out of selected proving installation are selected.
63, according to 61 described method of testings, it is characterized in that: after putting into testing element and detecting sample, before analyser starts test, also comprise the step that 100 test approaches that will carry out of selected proving installation are judged automatically.
64, according to 63 described method of testings, it is characterized in that: the subsidiary beacon information that test approaches is arranged on the testing element, judge test approaches after the beacon information on the Biochemical Analyzer read test element automatically.
65, according to 64 described method of testings, it is characterized in that: after each proving installation 100 was accomplished test, whether Biochemical Analyzer prompting test finished; Finish if select; Then close this TV station proving installation 100, if do not carry out any selection, then this TV station proving installation cut out after the 100 idle schedule times.
66, according to 65 described method of testings, it is characterized in that: after whole proving installation 100 cuts out, the Biochemical Analyzer shutdown.
67, according to 59 described method of testings, it is characterized in that: be provided with guide rail between the master control set 10 of Biochemical Analyzer and at least one proving installation 100, at least one proving installation 100 can slide in master control set 10.
68, according to 67 described method of testings; It is characterized in that: Biochemical Analyzer also includes the identical or close reagent storage unit 18 of appearance profile and size and proving installation 100; Be provided with the storage chamber 15 that profile and size and proving installation 100 and reagent storage unit 18 are complementary in the master control set 10; Storage chamber can optionally be accommodated proving installation 100 or reagent storage unit 18, and promptly storage chamber 15 can not only be taken in proving installation 100, also can take in reagent storage unit 18.
69, according to 68 described method of testings, it is characterized in that: be provided with guide rail between reagent storage unit 18 and the master control set 10.
Because adopt technique scheme, the present invention has brought following beneficial effect:
Through the mobile cooperation of slide block in the master control set guide rail on the proving installation, can realize that proving installation is installed on the master control set or with proving installation to disassemble in the proving installation from master control set.This operating process is simple, convenient.
Because can also take in the reagent storage unit in the storage chamber, the operator can be placed on the reagent of needs in the reagent rack of reagent storage unit in advance, the reagent of taking-up needs from described reagent storage frame easily just during detection.If certain type proving installation is used by long-term, but then its corresponding reagent storage unit also long-term storage in master control set, form man-to-man relation with proving installation, prevent to misuse reagent.The reagent storage unit is incorporated in the master control set, makes operating table surface be unlikely to pile with reagent bottle, prevents hazard events such as reagent bottle tipping.
Magnetic patch buckle structure of the present invention has utilized the principle that the same sex of magnetic patch is inhaled mutually, the opposite sex is repelled each other, and has effectively realized the assembling between proving installation and the master control set.Magnetic patch buckle structure of the present invention does not need the operator to use a lot of strength, does not need the operator to dismantle such as a lot of screw nut etc. yet, and whole process is very simple and convenient.
The rack-plate operation that utilizes on the step motor drive gear driven microscope carrier of the present invention; Thereby drive the motion of test paper test paper microscope carrier; Not only improved test speed, and stepper motor driving action stably continuously, can stablize and accurately microscope carrier is transported to the tram.
The track base that the bottom of microscope carrier is designed with on guide rail and the base is used, and makes level and smooth in proving installation, the moving of microscope carrier ability to have reduced interference of noise.
Baffle plate of the present invention not only plays good protection to the test strips microscope carrier in the proving installation and light emitted and receiving trap, makes microscope carrier and light emitted and receiving trap avoid external force collision, prevents dust pollution.Simultaneously when proving installation is deposited separately; Because proving installation is the structure of a sealing; When sample when retention in the proving installation that is removed has test or test agent; Reagent or sample residual on the microscope carrier can not be exposed in the external environment, prevent the pollution to surrounding environment and operator.
Biochemical Analyzer of the present invention also comprises the supporting structure that is used for the support operation panel, because guidance panel when establishing, has stent support thereafter, the operator is when using panel button, and guidance panel can not cave in backward.
Description of drawings
Fig. 1 Biochemical Analyzer synoptic diagram;
Fig. 2 Biochemical Analyzer guidance panel open mode synoptic diagram;
A view that proving installation is drawn out of in Fig. 3 Biochemical Analyzer;
The reagent storage cell schematics is arranged in Fig. 4 Biochemical Analyzer;
The rear structure synoptic diagram of Fig. 5 Biochemical Analyzer and proving installation;
The guidance panel of Fig. 6 Biochemical Analyzer is by second kind of design diagram of stent support;
The proving installation inner structure synoptic diagram of Fig. 7 Biochemical Analyzer;
The cut-open view of the proving installation of Fig. 8 Biochemical Analyzer A-A direction along the line;
The proving installation door of the proving installation of Fig. 9 Biochemical Analyzer is opened synoptic diagram;
The synoptic diagram that first magnetic patch and second magnetic patch attract each other in first kind of magnetic patch buckle structure of Figure 10;
First magnetic patch and the separated synoptic diagram of second magnetic patch in first kind of magnetic patch buckle structure of Figure 11;
Second kind of magnetic patch buckle structure of Figure 12 synoptic diagram;
The third magnetic patch buckle structure synoptic diagram of Figure 13;
Figure 14 Biochemical Analyzer test flow chart.
Embodiment
Below in conjunction with concrete accompanying drawing the present invention is carried out detailed explanation.These concrete embodiment only are limited the enumerating under spirit of the present invention, do not get rid of one of ordinary skill in the art and combine prior art and the present invention and other concrete embodiments of generation.
As shown in Figure 1, Biochemical Analyzer 1 of the present invention comprises a master control set 10 and one or separate proving installation 100 more than, and master control set 10 is connected with lead through electric connector 140 with proving installation 100.Each proving installation 100 can be accomplished test item and testing result is transferred to master control set 10 outputs according to the instruction of master control set 10 transmission independently of one another.Be designed to relatively independent relation between each proving installation 100, the dismounting that proving installation 100 can be freely carries out repeatedly with master control set 10.
To shown in Figure 6, include primary power 11 (connecting the each several part power supply of giving Biochemical Analyzer after the external goods electricity consumption) like Fig. 1 in the casing of master control set 10.Master control set 10 also includes master switch 12, guidance panel 13 and the printer 14 of analyser.Master switch 12, guidance panel 13 and printer 14 are electrically connected with primary power 11 respectively.Guidance panel 13 is touch display screens, both can show the interface and the testing result of testing process, and the person's touch screen that is not convenient to operation is again operated.
Be provided with one or the storage chamber 15 that above size is suitable basically with proving installation 100 in the casing of master control set 10 side by side.For proving installation can be pushed in the storage chamber 15 of master control set to quick and stable; At least the two side of storage chamber 15 is designed with guide rail 16 respectively; Perhaps the bottom design at storage chamber 15 has guide rail 17, perhaps all is designed with guide rail in the two side and the bottom of storage chamber.Said guide rail cooperates with slide block or pulley (not shown) on the proving installation.When proving installation is assembled into master control set or from the process that master control set disassembles, slide block or pulley on the proving installation slide in guide rail, the guiding proving installation gets into the storage chamber of master control set or leaves storage chamber 15.
As shown in Figure 4; Also can put into the size reagent storage unit 18 suitable basically with proving installation 100 in the described storage chamber 15 with shape; In the said reagent storage unit 18 one or more reagent storage frame 19 can be set; Be used to deposit the testing element of test usefulness, this testing element can be test agent or reagent bucket etc.The advantage of this design is, can be according to actual needs, and the storage chamber 15 whole installation testing devices 100 in the master control set 10, perhaps part installation testing device 100, other installation reagent storage unit 18, thus make design more flexible.Biochemical Analyzer 1 as shown in Figure 4 has comprised a master control set 10, two proving installations 100 and reagent storage unit 18.As more changeable embodiment more; Biochemical Analyzer 1 can comprise a master control set 10, one to ten; Even the proving installation more than ten 100 and one to ten; Even the reagent storage unit 18 more than ten, and the quantity of proving installation 100 and storage unit 18 can be according to needing arbitrarily combination.The reagent that the operator can need when detecting is placed in the reagent storage frame 19 in advance.When detecting, the operator can take out corresponding reaction reagent easily from the reagent storage unit of analyser.If proving installation is used by long-term, but then its corresponding reagent storage unit also long-term storage in master control set, form man-to-man relation with proving installation, prevent to misuse reagent.Reagent is all sorted out and is placed in the reagent storage unit in addition, makes operating table surface be unlikely to pile with reagent bottle, prevents hazard events such as reagent bottle tipping.
Be equipped with USB interface 26, fan 20, general supply access port 21 etc. on the shell of master control set 10.For the proving installation 100 that is pushed into is stably remained in the storage chamber 15, the position of corresponding each proving installation can also comprise bonnet lock hole 22 on the bonnet of master control set.
To shown in Figure 9, proving installation 100 comprises a base 101 like Fig. 7, and microscope carrier 102 designs of transporting test strip are on base, and light emitted and receiving trap 103 are positioned at the top of microscope carrier 102.Fixed Design has left socle 104 and right support 105 on base 101, and left and right sides support surrounds microscope carrier 102 within it.Light emitted and receiving trap 103 are installed on the support of the left and right sides, and perhaps Fixed Design has upper bracket 106 on the support of the left and right sides, and light emitted and receiving trap 103 are installed on the upper bracket 106.Microscope carrier 102 can move back and forth at predefined track; Light emitted and receiving trap 103 can near with away from microscope carrier 102, the motion track of microscope carrier 102 and light emitted and receiving trap 103 or the extended line of motion track intersect the perhaps orthogonal projection in same plane each other and intersect each other in same plane.
On at least one support 104 or 105, be designed with stepper motor 107, gear 108 is housed on the stepper motor.The microscope carrier 102 that transports test strip comprises the pallet 110 that is used to carry test strip 109.At least one side at microscope carrier 102 is designed with rack-plate 111 regularly.Rack-plate 111 engagements on said gear 108 and the microscope carrier 102.When stepper motor is worked, order about driven wheel and rotate, and then order about rack-plate 111 and make linear running, thereby the microscope carrier that will link to each other with rack-plate is delivered to test zone or withdrawed from from test zone.Stepper motor is higher to the ratio of precision of motion, therefore when the motion of gear driven rack-plate, has not only improved the speed of transporting test paper, and has improved the stability and the accuracy of test.
The medium position Fixed Design of base 101 has track base 112; Guide rail 113 on this track base 112 and the test strips microscope carrier 102 is used; Microscope carrier 102 can slide along track base in proving installation, arrives the detection position or withdraws from test zone thereby transport test-strips.Described guide rail 113 designs in the bottom of microscope carrier 102.
A temperature control equipment 114 is arranged below the test zone that is positioned at test strips on the microscope carrier.When the environment temperature of test does not meet predefined temperature range, temperature control equipment will be regulated temperature (for example heating) automatically, make the temperature of test environment meet predefined temperature range.Temperature control equipment comprises resistive heating device, and transmits temperature through potsherd or sheet metal.
The left and right sides of proving installation base 101 can also respectively be mounted with a take-up housing 120, and take-up housing 120 is through being bolted on the base 101.Slide block 121 Fixed Design are on take-up housing 120; This slide block 121 can be free to slide in the guide rail 16 of storage chamber 15 sidewalls; Move in storage chamber 15 thereby drive whole testing device, proving installation is pushed into storage chamber and prepares to carry out the detection of analyte, perhaps is moved out of storage chamber.The take-up housing that has slide block can also be arranged on the bottom of base, is used with bottom guide track 17 in the storage chamber.As the change design, take-up housing 120 also can be an integral body with slide block 121, can also be a bar that matches with guide rail 16.
For better protection test microscope carrier and light emitted and receiving trap, can also respectively be designed with baffle plate 122-126 all around, promptly right baffle plate 122, right baffle-plate 123, overhead gage 124, front apron 125 and backboard 126 at proving installation 100.On front apron 125, be designed with a proving installation door 127, proving installation door 127 can be connected through the hinge with front apron 125.When proving installation did not use or detecting, the proving installation door was closed.When the test strips microscope carrier in the proving installation need transport test strip, the proving installation door was opened, and the handled easily person deposits or take out test paper.Said baffle plate plays good protection to the test strips microscope carrier in the proving installation and light emitted and receiving trap, makes microscope carrier and light emitted and receiving trap avoid external force collision, and can prevent dust pollution.When proving installation during by whole taking out, reagent or sample residual on the microscope carrier can not be exposed in the external environment, prevent the pollution to environment simultaneously.
Light emitted and receiving trap 103 comprise the electro-motor 130 (preferred stepper motor) that promotion light emitted and receiving trap move up and down, light emitted device 131.Light emitted and receiving trap 103 also comprise the optical coupled switch 132 of control light supply apparatus movement position, and said smooth lotus root switch 132 is electrically connected with said electro-motor 130, is used to control said electro-motor 130 operations and braking.Said smooth lotus root switch 132 has lightening hole 133, and light emitted and receiving trap have shutter 134.Said shutter 134 has the lightening hole of blocking 133 and leaves 133 two positions of lightening hole with respect to lightening hole 133.In light emitted and the downward operational process of receiving trap, when shutter 134 is positioned at lightening hole 133 tops of light lotus root switch 132, this moment, light path was unimpeded, and power supply keeps power supply state always, and light supply apparatus continues to move downward under electro-motor 130 rotates.When shutter 134 had stopped the lightening hole 133 of light lotus root switch 132, light path was cut off, thereby closed the power supply of electro-motor 130, and light supply apparatus is no longer descending, opened 131 pairs of samples of sample detection light source simultaneously and detected and analyze.
Each proving installation 100 can also comprise independently microprocessor; Can carry out the movement position, test environment temperature and the heating plate heating supervisor that include but not limited to for example control light emitted device, monitoring pallet, and transmit data to the external world through data transmission interface.
Proving installation 100 also can comprise power interface and data transmission interface, realizes to proving installation power supply and test transmission result.The also available integrated electric connector 140 of proving installation 100.Described electric connector is the device that power interface and data transmission interface are integrated, and this just makes proving installation have more space to deposit other accessories, has also reduced the operation of producing, and enhances productivity.Proving installation is connected with master control set through electric connector, accepts master control set proving installation is supplied power, or give the data output device of master control set with data transmission.The electric connector of proving installation also can be connected on other the data output device.
The detection light source that is adopted on each proving installation can be identical or different.When detection light source that a plurality of proving installation adopted is identical, can improve the speed and the efficient of detection.If the detection light source that proving installation adopted is different, each proving installation can be measured the identical or different biochemical parameter of identical or different samples, thereby realizes a tractor serves several purposes.Master control set that other are any and the array mode between the proving installation all are suitable.
In order to guarantee that proving installation well is fixed on the master control set, can on proving installation and master control set, be provided with proving installation is fixed to the buckle structure on the master control set.Described buckle structure can be fixed form, buckle snap close or the magnetic patch snap close of screw thread snap close (for example bolt and nut, screw and threaded hole).The structure of described magnetic patch snap close to shown in Figure 13, comprises at least three magnetic patch like Figure 10, first magnetic patch 151, second magnetic patch 152 and the 3rd magnetic patch 153.151 designs of first magnetic patch are on first device, and second magnetic patch 152 and 153 designs of the 3rd magnetic patch are on second device.The magnetic different (being respectively the S utmost point and the N utmost point) of two faces that first magnetic patch 151 is relative with second magnetic patch 152, the magnetic identical (be all the S utmost point or be all the N utmost point) of two faces that second magnetic patch 152 is relative with the 3rd magnet 153.First magnetic patch 151, second magnetic patch 152 and the 3rd magnetic patch 153 are roughly overlapping perpendicular to the projection on the direction of its opposite face.If with two mutual snap closes of device when living; Second device that first device that will have first magnetic patch 151 pushes to have second magnetic patch 152 near; First device and second device finally are attached together through magnetic force, and at this moment, the 3rd magnetic patch 153 is away from second magnetic patch 152.If two devices are separated from each other; This moment with the 3rd magnetic patch 153 push to second magnetic patch 152 near; Utilize the mutual repulsive force between the 3rd magnetic patch 153 and second magnetic patch 152 and first magnetic patch 151; Weakened the magnetic attraction between first magnetic patch 151 and second magnetic patch 153, thereby first device and second device are separated from each other.
Biochemical Analyzer of the present invention such as Figure 10 are to embodiment shown in Figure 11, and 151 designs of first magnetic patch are on the backboard 126 of proving installation 100.Second magnetic patch 152 is entrenched in the bonnet lock hole 22 of master control set 10.On the master control set bonnet, be designed with two bracing frames 154, support frame as described above 154 designs the both sides at bonnet lock hole respectively.The 3rd magnetic patch 153 is connected with bracing frame 154 through spring leaf 155.The magnetic different (being respectively the S utmost point and the N utmost point) of two faces that first magnetic patch 151 is relative with second magnetic patch 152, the magnetic identical (be all the S utmost point or be all the N utmost point) of two faces that second magnetic patch 152 is relative with the 3rd magnetic patch 153.State in the storage chamber 15 of shown in Figure 10 is proving installation 100 is pushed into master control set 10; At this moment; There is a natural attraction between the sexes because of magnet for first magnetic patch 151 and second magnetic patch 152, and this magnetic attraction makes that proving installation is inhaled on master control set firmly, and can from master control set, not skid off.Shown in figure 11; When needs are extracted proving installation 100 out, the 3rd magnetic patch 153 is pushed away to the second magnetic patch direction, because the polarity of second magnetic patch 152, two faces relative with the 3rd magnetic patch 153 is identical; And the polarity of the face that the 3rd magnetic patch 153 is relative with first magnetic patch 151 also is identical; According to the principle that the same sex of magnet is repelled each other, 153 pairs first magnetic patch of the 3rd magnetic patch and second magnetic patch all have a repulsive interaction, have weakened the magnetic attraction between first magnetic patch 151 and second magnetic patch 152.Along with the 3rd magnetic patch 153 near, this repulsive force can basic neutralisation first magnetic patch 151 and second magnetic patch 152 between magnetic attraction.Thereby proving installation 100 just can be extracted out from the storage chamber of master control set at an easy rate.
Figure 12 is the another kind of embodiment of magnetic patch buckle structure, and the 3rd magnetic patch 153 can slide on slide bar 156 through slide bar button 157.Figure 13 is the another kind of embodiment of magnetic patch buckle structure, and the 3rd magnetic patch 153 is conflicted through snak link 159 and spring 158 each other, and spring has the state that is compressed and unfold by the 3rd magnetic patch.
Testing process is shown in figure 14 between master control set and the proving installation.Workflow is: opening power at first, the Biochemical Analyzer start also gets into the startup self-detection program, treat that startup self-detection finishes after; Get into preheating program, when the probe temperature of Biochemical Analyzer met predefined temperature range, detector was in the wait test mode; The operator selects the proving installation that need test, put into the test paper bar after, analyser starts test; Behind the EOT, output test result, take out the test paper bar.Then put into new test paper bar once more if also will carry out the detection of next sample, the mensuration of a beginning new round.If all samples has all been tested completion, then shutdown.
Claims (10)
1. method of testing that adopts Biochemical Analyzer to measure the biological specimen parameter is characterized in that: may further comprise the steps: 1) opening power, and the Biochemical Analyzer start also gets into the startup self-detection step; 2) after startup self-detection was passed through, Biochemical Analyzer got into preheating step; 3) when the probe temperature of Biochemical Analyzer satisfies predefined temperature conditions, prompting is put into testing element and is detected sample; 4) Biochemical Analyzer starts test; 5) after test is accomplished, output test result; 6) prompting is taken out used testing element and is detected sample; 7) whether prompting detects and finishes; 8) if select not finish, then prompting is put into new testing element and is detected sample, and repeating step 4 then)-6); 9) if select to finish, then shutdown finishes test.
2. method of testing according to claim 1; It is characterized in that: said Biochemical Analyzer comprises master control set (10) and at least one proving installation (100); The startup self-detection step comprises whether the state of checking each equipment is normal, and the quantity of checkout device (100).
3. method of testing according to claim 2; It is characterized in that: when the quantity of proving installation (100) is equal to, or greater than two; After the step that startup self-detection is passed through, before the preheating step, also comprise and select to open the step that which platform or which platform proving installation (100) are tested.
4. method of testing according to claim 3; It is characterized in that: after having selected the step that proving installation (100) tests or behind the preheating step, also comprise to selected proving installation (100) the step selected of the test approaches that will carry out.
5. method of testing according to claim 3 is characterized in that: after putting into testing element and detecting sample, before analyser starts test, also comprise to selected proving installation (100) the step judged automatically of the test approaches that will carry out.
6. method of testing according to claim 5 is characterized in that: the subsidiary beacon information that test approaches is arranged on the testing element, judge test approaches after the beacon information on the Biochemical Analyzer read test element automatically.
7. method of testing according to claim 6; It is characterized in that: after each proving installation (100) is accomplished test; Whether Biochemical Analyzer prompting test finishes, if select to finish, then closes this TV station proving installation (100); If do not carry out any selection, then this TV station proving installation (100) cut out after the idle schedule time.
8. method of testing according to claim 7 is characterized in that: after whole proving installation (100) cuts out, and the Biochemical Analyzer shutdown.
9. method of testing according to claim 1 is characterized in that: be provided with guide rail between the master control set of Biochemical Analyzer (10) and at least one proving installation (100), at least one proving installation (100) can slide in master control set (10).
10. method of testing according to claim 9; It is characterized in that: Biochemical Analyzer also includes the appearance profile reagent storage unit (18) identical or close with proving installation (100) with size; Be provided with the storage chamber (15) that profile and size and proving installation (100) and reagent storage unit (18) are complementary in the master control set (10), storage chamber can optionally be accommodated proving installation (100) or reagent storage unit (18).
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| WO2022052364A1 (en) * | 2020-09-09 | 2022-03-17 | 广州万孚生物技术股份有限公司 | Biochemical analyzer |
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| CN102375071B (en) | 2014-04-16 |
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