CN102232875B - Threaded biomedical implant structure and selective surface treatment method thereof - Google Patents
Threaded biomedical implant structure and selective surface treatment method thereof Download PDFInfo
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- CN102232875B CN102232875B CN 201010166884 CN201010166884A CN102232875B CN 102232875 B CN102232875 B CN 102232875B CN 201010166884 CN201010166884 CN 201010166884 CN 201010166884 A CN201010166884 A CN 201010166884A CN 102232875 B CN102232875 B CN 102232875B
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Abstract
The invention discloses a threaded biomedical implant structure and a selective surface treatment method thereof. The surface of the biomedical implant structure has threads and a plurality of nano holes, wherein the holes are only distributed in an area between threads. The method comprises: providing a biomedical implant structure with threads on the surface; cleaning the surface of the biomedical implant structure; performing heat treatment and anodic treatment on the biomedical implant structure; and forming the plurality of nano holes on the surface of the biomedical implant structure. The nano holes are selectively grown between the threads, and electrolyte used in the anodic treatment contains fluorinions. In the biomedical implant structure and the selective surface treatment method thereof, the nano holes are selectively grown only in the area between the threads on the surface of the implant structure, so when the implant structure is stressed, the parts where the threads with relative low strength are formed are insusceptible to deformation or collapse due to stress; and after being implanted into a human body, the implant structure does not loose off.
Description
Technical field
The present invention has giving birth to of bioactive substance and nanoscale hole about a kind of doctor of giving birth to implant structure, particularly a kind of surface and cures implant structure, and does the surface-treated method to giving birth to doctor's implant structure.
Background technology
Generally speaking, plant body behind implant into body, pathological changes occurs around must avoiding causing tissue, namely plant body and can not discharge or dissociate noxious substance, therefore can not cause the reaction of blood coagulation (blood coagulation) or haemolysis (hemolysis), the head phase capacitive (biocompatibility) of living again on material is selected.
Often being applied at present to give birth to the metal material that the doctor plants body is rustless steel, titanium alloy, chromium-cobalt alloy etc., wherein again with the most normal use of titanium, except the original engineering properties of metal is good, when titanium is exposed in air, the water or in the organism, can spontaneously generate the oxide layer of high stability and have splendid biocompatibility, point out the absorption that the titanium deoxid film of anatase (anatase) structure can effectively improve protein, and the generation of minimizing fibrous tissue according to research; But because titanium dioxide has the character of biologically inert, if this implant will be fixed in the relatively poor organism of bone health, what itself and surrounding tissue and bone restoration situation own and effect will be not as expections relatively will be good.
Take tooth root implant as example, if tooth root implant is selected the material of tool chemical stability and surface smoothness, then more can not produce toxicity and zest, but this kind material surface is smooth, can produce reaction and bond with surrounding tissue hardly, therefore can around tooth root implant, form about 0.1～10 μ m fibrous capsule (fibrous capsule).
Because this peplos is not to be connected with tooth root implant, in the situation that peplos continues to thicken, can block the supply of surrounding tissue blood flow, cause the accumulation of root of the tooth surrounding tissue refuse to cause inflammation to form cyst; In addition, peplos calcification and sclerosis are urged to the tooth root implant surrounding tissue, also can cause local pain; In addition, owing to be subjected to Stress non-homogeneity, and cause tooth root implant or surrounding tissue is impaired, pain or artificial tooth root get loose phenomenon.
For fear of the problem of above-mentioned peplos, can carry out surface treatment for the tooth root implant surface on the traditional handicraft.And to the mode that process on the tooth root implant surface, comprise for doing the blasting treatment of etching or interior erosion Cavitated, the coating coating is done on the tooth root implant surface processed in the tooth root implant surface, or sintered particles is in the sintering process of planting the surface and form hole.
For traditional blasting treatment, because blasting treatment is to utilize kinetic energy bump, so the distance between blasting treatment tooth root implant surface hole defect later is larger, and size dimension differs, mechanical strength a little less than; And the hole degree of depth there is no too large help at micrometer range for hyperplasia, attaching, differentiation; In addition, after surface treatment is complete, if without through carefully cleaning and sterilization, behind implant into body, cause easily allergic phenomena; In addition, the mode that the hole of blasting treatment generates because there is not selectivity, therefore can produce reaction in stressed larger part, and tooth root implant can collapse or deformation because the stressed young's modulus that surpasses itself produces.
And for doing the mode that the coating coating is processed in the tooth root implant surface, because tooth root implant surface and coating be each other without any chemical bonded refractory, easily behind implant into body, cause obscission under long-time and lose former capable.
Be that adopt high temperature be issued to surfaction effect as for the sintering rule more, but in pyroprocess, tend to cause the tooth root implant crystalline phase to change and so that physics and chemical property change, so the selection of tooth root implant material limits to some extent.
In addition, for tooth root implant itself, in order to promote the hyperosteogeny of periodontal tissue, also can add various growth material.The relevant method that active material is coated on the metal material has a lot of modes, and the mode of wherein accepting extensively most is the plasma spraying method.The problem of plasma spraying method fixed form is, because plasma spraying is to carry out under 1000 ℃ of high temperature, to be deposited on carrier upper outside except somatomedin, can make somatomedin unstable and produce many noncrystalline phases under the high temperature, and then affect purity and the conjugation of tooth root implant and somatomedin, add that tooth root implant is different from the thermal coefficient of expansion of somatomedin, can cause great stress between interface, easily at implant into body through for a long time with after body fluid contacts, cause obscission and lose and organize between adhesion, and the method also can't be fixed in the tooth root implant of porous character growth material is stable.
In TaiWan, China patent application TW093117549, provide a kind of living doctor's implant and method for making thereof with sucked type nano aperture, and exposure utilizes electrochemical means to form hole on the orthopaedics implant surface.Although utilize the method can form a plurality of nano apertures, being characterized as of its surface hole defect is not separate to link to each other between hole wall and hole wall, implant may be too weak on overall mechanical strength, when implant is stressed, may because of independent pore space structure, cause and plant body deformability or avalanche.And it does not disclose the method that how active substance is coated in the hole.
Therefore, how overcoming above-mentioned tooth root implant surface-treated defective, can provide periodontal tissue's hyperosteogeny again, take into account simultaneously the mechanical strength of implant structure, is the problem that institute of the present invention wish solves.
Summary of the invention
In view of this, main purpose of the present invention provides living doctor's implant structure that a kind of hole optionally generates in pitch, wherein give birth to doctor's implant structure surface and have screw thread and a plurality of nanoscale hole, those holes only are distributed in the zone between those screw threads and the screw thread, and the spacing of any two holes is greater than 5nm, the average diameter size of those hole openings is between 10 to 500nm, and the generation direction of those holes has single direction.Giving birth to doctor's implant structure can strengthen and biocompatible and bone conformability in response to increase bioactive substance with demand again, therefore, also comprises a bioactive substance at the described doctor's implant structure of giving birth to, and is distributed in implant structure top layer and those holes.
Another object of the present invention provides a kind ofly does the surface-treated method to implant structure, and comprising: an implant structure is provided, and the material of implant structure is metal; Implant structure is carried out cleaning surfaces; Impose a heat treatment, can under the environment such as vacuum, inertia, passivity gas, carry out; Then, form the burning layer film in the implant structure surface in the anodising mode, and form a plurality of nanoscale holes in the implant structure surface, wherein, utilize the employed electrolyte of anodising mode to contain fluorion, for example ammonium fluoride; At last, can strengthen and biocompatible and bone conformability in response to increase again bioactive substance with demand, fix a bioactive substance and be distributed in implant structure top layer and those holes.
Use selective surface provided by the present invention to process the tool thread structure and give birth to the method that the doctor plants body, the implant structure after the processing has following advantages:
The nanoscale hole only selectivity be created on zone between implant structure thread surface and the screw thread, when implant structure is stressed, the relatively weak place, screw thread place of intensity is not easy because of stressed deformation or avalanche to occur, and causes implant structure to get loose behind implant into body.
2. the generation direction of nanoscale hole has very strong unicity, makes implant structure inside can not reduce because communicating between the hole mechanical strength of implant structure.
3. increase contact area and the bone guided (Osteoconductive) of implant structure and osseous tissue, allow osteocyte be easy to growth.
4. can the electrochemical deposition mode scatter or the filled biomass active substance in the hole of implant structure, make implant structure behind implant into body, have osteoinductive (Osteoinductive), make the active increase of osteocyte, integrate (Osseointegration) time with the bone that reduces implant structure and tissue.
To sum up, after implant structure is processed by surface treatment method provided by the present invention, can be by increasing the surface area of tissue and implant structure contact, promote hyperosteogeny, reach the function that bone guided (Osteoconductive), bone are induced (Osteoinductive), effectively shorten bone and integrate (Osseointegration) time, needed rehabilitation period after the shortening patient underwent operative.
Description of drawings
The sketch map of Figure 1A embodiment of the invention tooth root implant implant into body;
The tooth root implant structure of Figure 1B embodiment of the invention;
The tooth root implant structure partial enlarged drawing of Fig. 1 C embodiment of the invention;
Fig. 1 D is along the profile of A-A transversal among Fig. 1 C;
The flow chart of Fig. 2 surface treatment method of the present invention; And
When Fig. 3 A～3D carries out anodising, the hole generative process sketch map on implant structure surface.
The component symbol explanation
1 ... tooth root implant structure 10 ... the nanoscale hole
11 ... bioactive substance 12 ... screw thread
120 ... zone 13 between screw thread and the screw thread ... the oxide layer thin film
The specific embodiment
About selective surface of the present invention process the tool thread structure give birth to method that the doctor plants body with and give birth to doctor's implant structure, can pass through following detailed description and appended graphic, be further understood.
In order proposed by the invention the giving birth to of clearer description to cure the feature of planting body, now cooperate graphic being described in detail as follows.The doctor's implant structure of giving birth to proposed by the invention has screw thread, can be applicable to tooth root implant, nail, hone lamella etc.In the present invention, as an embodiment, cooperate diagram to give a detailed account with a tooth root implant structure.
Please refer to Figure 1A～1D, Figure 1A shows the sketch map of the embodiment of the invention, is the tooth root implant structure 1 actual situation of implanting dental bed of the present invention.Figure 1B is the tooth root implant structure of the embodiment of the invention.
Because implant structure is behind implant into body, need to consider can not cause implant structure surrounding tissue generation pathological changes, therefore its material must be selected the material of tool biocompatibility, arbitrary existing biocompatibility metal or metal alloy compositions all can be selected, and are in the present invention to select titanium as the material of tooth root implant structure 1.
This be because titanium except the original engineering properties of metal is good, its surface forms easily titanium dioxide, belongs to the ceramic material of inertia, is not easy and other material produces reaction; Titanium dioxide has ratio aluminum oxide and the better biocompatibility of zirconium oxide, therefore, when titanium dioxide converts rutile structure to, can improve biocompatibility; In addition, the surperficial acid and alkali-resistance that titanium dioxide consists of effectively prevents disengaging of titanium ion.
Fig. 1 C is the tooth root implant structure partial enlarged drawing of the embodiment of the invention, and Fig. 1 D is along the profile of A-A transversal among Fig. 1 C.Wherein tooth root implant structure 1 surface has a plurality of nanoscale holes 10 and a bioactive substance 11.
Grow up in order to allow osteocyte can attach tooth root implant structure 1, increase its bioconjugation power, tooth root implant structure 1 surface can have a plurality of nanoscale holes 10, and hole opening average diameter size about 10 is to 500nm.Because tooth root implant structure 1 is behind implant into body, need consider that also the mechanical strength of implant structure can not be too a little less than, therefore, hole opening average diameter size about 10 to 80nm be the best.In embodiments of the present invention, the spacing of adjacent two holes needs at least greater than 5nm.The size of spacing then adjusts according to the situation of user.
Be noted that in embodiments of the present invention as shown in Figure 1B, tooth root implant structure 1 surface also has screw thread 12, so that tooth root implant structure 1 is fixed in the dental bed.Because the mechanical strength of screw thread 12 compared to the zone 120 between screw thread and the screw thread a little less than, therefore, aforesaid nanoscale hole 10 only is distributed in the zone 120 between screw thread and the screw thread.
The present invention provides simultaneously a kind of selective surface to process the tool thread structure and gives birth to the method that the doctor plants body.With reference to Fig. 2, be the flow chart of the embodiment of the invention.Implant structure is done the surface-treated purpose, namely be to allow the implant structure surface form a plurality of nanoscale holes, allow osteocyte be easy to growth.Method provided by the present invention is not limited to the employed implant structure of the embodiment of the invention, and other saves implant such as the pass, or the bone surgery implant etc., also can use method of the present invention to form hole on the surface, and bioactive substance.What the embodiment of the invention provided does the surface-treated method to implant structure, comprising:
S10: the threaded doctor of giving birth to of a tool at first is provided implant structure.As previously mentioned, giving birth to doctor's implant structure is a tooth root implant structure 1 in embodiments of the present invention.And the material of implant structure is the metal of arbitrary tool biocompatibility, and the embodiment of the invention selects titanium or titanium alloy as the material of tooth root implant structure 1;
S15: carry out cleaning surfaces to giving birth to doctor's implant structure.Because the titanium test piece of tool blemish or impurity has a great impact in nano aperture generates, therefore before preparation, need to carry out cleaning surfaces to giving birth to doctor's implant structure as much as possible.In the embodiment of the invention, utilize acetone, ethanol, deionized water to vibrate to remove surperficial oil stain and dirty respectively at ultrasound.
S20: do heat treatment to giving birth to doctor's implant structure, make and give birth to the original stress effect disappearance of doctor's implant structure and increase its oxide layer density.When doing heat treatment, can be chosen in vacuum, carry out under inertia or the passivity gas.The purpose of this step is that hole is only formed in the zone between screw thread 12 and screw thread 12 120, and is not formed at the jut of screw thread 12 as far as possible.Because stressed larger at the threaded bosses place, if also form hole in this part, when tooth root implant structure 1 is stressed, easily make the relatively weak place, screw thread place of intensity more fragile.
Because common metal is strong in place, tip oxidizing force, it is also more to be heated when heat treatment, therefore makes original oxide layer thin film 13 more fine and close behind heat treatment, and the effect of similar protective layer is so that when anodising, reduce the generation of threaded bosses part hole.And in vacuum, do heat treatment in the environment under inertia or the passivity gas, and be at high temperature to form too thick oxide layer thin film 13 in tooth root implant structure 1 surface for fear of airborne oxygen, cause follow-up when doing anodising, to be difficult to generate hole.On the other hand, in heat treatment process, also eliminate tooth root implant structure 1 original stress effect own and make the originally contained oxide layer thin film 13 in living doctor's implant structure surface finer and close and firm.The embodiment of the invention is in vacuum about 10
-1To 10
-8Under the environment of torr, about 200 to 900 ℃ of heat treatment temperature.Most preferred embodiment is in vacuum about 10 with life doctor implant structure
-2To 10
-4Under the environment of torr, implant structure is warming up to about 600 to 700 ℃.
S25: impose electrochemical process polishing implant structure.Electrochemical polish then utilizes butyl glycol ether (Ethylene Glycol Butyl ether, EG), methanol (Methanol) and crosses the electropolishing liquid that chloric acid (Perchloric Acid) mixes.Take tooth root implant structure 1 as anode, platinum (99.9%Platinum, Pt) is negative electrode, under the appropriate reaction parameter, carry out electrochemical polishing treatment, after polishing finishes, test piece is soaked in absolute methanol and with ultrasonic vibrating, the reactant that produces with polishing the time is removed.
S30: form burning layer film 13 in tooth root implant structure 1 surface in the anodising mode, and form a plurality of nanoscale holes 10 in tooth root implant structure 1 surface.Giving birth to doctor's implant structure surface formation hole, decapacitation makes its mechanical strength variation have seriality, and can increase the contact area of planting body and osseous tissue, and increases osteocyte or osseous tissue mechanical chimeric (interlocking) effect.
The electrolyte of anodising contains fluorion, and the embodiment of the invention is to use ammonium fluoride (NH
4F) collocation ethylene glycol (Ethylene Glycol, EG) and deionized water as electrolyte, and respectively with platinum (99.9%Platinum, Pt) be negative electrode, (material is pure titanium to implant structure, 99.5% Titanium) be anode, connect with the mains the respectively negative, positive utmost point of supply of the two poles of the earth is put into electrolyte and is carried out anodising.Change experiment parameter, apply current potential, electric current, response time, reaction temperature, electrolyte water content, fluorinion concentration such as reaction, but the size of the wide open mouth of control hole.Such as in embodiments of the present invention, wide open mouthful of average diameter about 10 of control hole be preferably 10 to 80nm, and the spacing of adjacent two holes needs greater than about 5nm at least to 500nm, with the overall mechanical strength of assurance tooth root implant structure 1.Therefore, the concentration about 0.1 of control ammonium fluoride is to 20wt%, but when experiment test of the present invention, ammonium fluoride concentration about 0.1 can obtain optimum to 0.4wt%.And apply about 10 to 90 volts of voltage range, about 40 volts of optimal parameter.About 5 minutes to 1200 minutes of response time.
Behind anodising, again carry out cleaning step S301, test piece is soaked in the absolute methanol, and with ultrasonic vibrating machine concussion 20 minutes, to remove remained on surface electrolyte.
Wherein, in the anodising process, form the mechanism of burning layer film 13, please refer to Fig. 3 A～3D, when carrying out anodising for method of the present invention, give birth to the sketch map of doctor's implant structure surface hole defect generative process.With the titanium of the embodiment of the invention, be because in the anodising process, apply current potential in tooth root implant structure 1 (titanium), make it to occur oxidation reaction, produce titanium ion (Ti
4+), cause the anode part chemolysis, such as reaction equation (1), and the electrolysis of water occurs simultaneously, make hydrone be dissociated into oxonium ion (O
2-) and hydrion (H
+), such as reaction equation (2).Titanium ion is combined with oxonium ion, forms the oxide layer thin film 13 of titanium in the surface, such as reaction equation (3), causes the ohmic polarization phenomenon, is referred to as barrier layer (barrier layer), as shown in Figure 3A;
Ti+4e
-→Ti
4+ (1)
H
2O→2H
++O
2- (2)
Ti
4++2O
2-→TiO
2 (3)
Then, forming nanoscale hole 10, is because fluorion (F
-) will replace the position of oxonium ion, with Ti
4+Form [TiF
6]
2-Ion misfit thing, shown in (4), titanyl layer film 13 is produced local chemolysis (chemical dissolution), make barrier film generation ionizing and be porous porous layer (porous layer), shown in Fig. 3 B:
TiO
2+6F
-+4H
+→[TiF
6]
2-+2H
2O (4)
Along with the time continue to prolong, electric field and fluorion continue to increase the weight of to the topochemistry dissolution degree that titanium and thin film of titanium oxide 13 cause, and the degree of depth of hole and width can strengthen gradually, change nano tubular structure into.Because the nanotube walls structure is looser, and be the fine and close structure of structure at the bottom of the mouth of pipe and the pipe, so the response time is more of a specified duration, the degree of depth of nanoscale hole is darker, and the aperture is larger, but the spacing between two adjacent holes is less, shown in Fig. 3 C and 3D.
It should be noted that with of the present invention and cure implant structure surface-treated method to giving birth to, when forming nanoscale hole 10, it generates direction and has very strong directivity, shown in Fig. 3 A～3D.Be not connected owing to give birth between doctor's implant structure inner void, can not cause integrally-built avalanche, and can keep certain mechanical strength.
By the theory of blemish as can be known, defective namely is made of than institutes such as out-of-flatness part, poor row, hole, crystal boundary, surperficial precipitates the surface; Because the current potential that applies is the DC voltage for single direction, single plane, and (Free Energy) is lower for the fault location free energy, therefore when electric field applies, electric charge is gathered in first the fault location on surface, the polarization phenomena that cause charge accumulation and electric field to concentrate, and generating portion chemolysis; Add owing to contain fluorion (F in the electrolyte
-), so fluorion will replace the oxonium ion position in the titanium oxide and produce ion misfit thing [TiF with titanium
6]
2+, this phenomenon also causes the part chemolysis phenomenon at blemish place, because the ion misfit thing [TiF that produces
6]
2-The components and concentration contained in fault location must greater than other surface portion, the concentration diffusing phenomenon therefore occur; More than two factors be to impel the generation direction of nanoscale hole to have the reason of single direction.
In addition, be noted that the employed doctor's of giving birth to implant structure is the threaded tooth root implant of a surperficial tool in the invention process.Because previous vacuum heat step S20 makes the oxide layer of threaded portion comparatively fine and close, so in this step, when the nanoscale hole generates, can optionally be distributed in the zone between screw thread and the screw thread.
S35: a bioactive substance is distributed in tooth root implant structure 1 top layer and those holes, and bioactive substance mainly comprises calcium, P elements and hydroxy.With electrodeposition process bioactive substance to be distributed in to give birth in doctor implant structure surface and the hole in the embodiment of the invention, but in fact be not limited in this mode of utilizing, also can utilize prior art that bioactive substance is coated in and give birth to doctor's implant structure, such as: the modes such as plasma spraying method, impregnation method, sol-gel process, ion sputtering deposition method.
Comprise phosphorus and calcium ion during plating in the employed electrolyte.At first, utilize calcium and phosphorus predecessor, as: CaCl
2, NH
4H
2PO
4Deng, be dissolved in the deionized water, as the supplier of calcium and phosphorus.Implant structure (99.5% Titanium is cured in complete the giving birth to of anodising, Ti) be fixed in negative electrode, anode then is platinum (99.9%Platinum, Pt), after inserting two utmost points in the electrolysis bath, fill or be coated in nano aperture to carry out bioactive substance under the appropriate reaction parameter.Parameter comprises that reaction applies current potential, response time, reaction temperature and electrolyte content and forms etc., and adjusts proper pH value.
S40: the test piece after the plating with washed with de-ionized water after in the baking oven inner drying.
Though the present invention illustrates as above with preferred embodiments, so it is not to limit the present invention.Allly be familiar with the technique personnel, when understanding easily and utilize other element or mode to produce identical effect.Therefore, the modification of doing within not breaking away from spirit of the present invention and protection domain all should be included in the scope of the application's claim protection.
Claims (18)
1. give birth to doctor's implant structure for one kind, it is characterized in that, this life doctor implant structure surface has screw thread and a plurality of nanoscale hole, the zone of those hole distributions between those screw threads and screw thread, and the spacing of any two holes is greater than 5nm, the average diameter size of those hole openings is between 10 to 500nm, and the generation direction of those holes has single direction.
2. the doctor's implant structure of giving birth to as claimed in claim 1 is characterized in that, this life doctor implant structure is a tooth root implant structure, and material is metal or alloy.
3. the doctor's implant structure of giving birth to as claimed in claim 2 is characterized in that, this life doctor implant structure material is titanium.
4. as claimed in claim 1 giving birth to cured implant structure, it is characterized in that, this life doctor implant structure also comprises a bioactive substance, is distributed in this life doctor implant structure top layer and those holes, to increase the compatibility and the bone conformability of this life doctor's implant structure and organism.
5. the doctor's implant structure of giving birth to as claimed in claim 4 is characterized in that this bioactive substance contains calcium, P elements and hydroxy.
6. a selective surface processes the method that the tool thread structure is given birth to doctor's implant structure, it is characterized in that, comprising:
Provide and cure implant structure all one's life, the surface of this life doctor implant structure has screw thread, and material is metal or alloy;
Clean this life doctor implant structure surface;
Impose a heat treatment in this life doctor implant structure; And
The anodising mode that imposes is in this life doctor implant structure, to form a burning layer film in this life doctor implant structure surface, and in a plurality of nanoscale holes of this living doctor's implant structure surface formation, those hole selective growth zones between those screw threads and screw thread, wherein, the employed electrolyte of this anodising mode comprises fluorion.
7. method as claimed in claim 6 is characterized in that, imposes heat treatment when this life doctor implant structure, is to do heat treatment under vacuum, inertia or passivity gas.
8. method as claimed in claim 6 is characterized in that, imposing heat treatment is in vacuum 10 in this implant structure
-1To 10
-8Under the environment between the torr, and heat-treat the density of planting the body oxide layer on surface of material to increase this between in 200 to 900 ℃ of this implant structures.
9. method as claimed in claim 6 is characterized in that, this life doctor implant structure is a tooth root implant structure, and the material of this implant structure is titanium or titanium alloy.
10. method as claimed in claim 6 is characterized in that, imposes a heat treatment behind this life doctor implant structure, before with anodising this implant structure being processed, also comprises:
Use butyl glycol ether, methanol and cross the electropolishing liquid that chloric acid mixes, with electrochemical means this implant structure is carried out polishing; And
This implant structure is soaked in absolute methanol and cooperates a ultrasonic energy that this implant structure is shaken, the reactant that produces with polishing the time is removed.
11. method as claimed in claim 6 is characterized in that, when with anodising this implant structure being carried out surface treatment, employed electrolyte comprises ammonium fluoride, ethylene glycol and deionized water, and wherein, the concentration of ammonium fluoride is between 0.1 to 20wt%.
12. method as claimed in claim 11 is characterized in that, when imposing anodising this implant structure being carried out surface treatment, the concentration of ammonium fluoride is between 0.1 to 0.4wt%.
13. method as claimed in claim 6 is characterized in that, also comprises a bioactive substance is distributed in this implant structure top layer and those holes behind anodising, with biocompatible and the bone conformability that increases this implant structure.
14. method as claimed in claim 13 is characterized in that, when being distributed in this bioactive substance in this implant structure top layer and those holes, can select electricity consumption sedimentation, plasma spraying method, impregnation method, sol-gel process or ion sputtering deposition method.
15. method as claimed in claim 13 is characterized in that, this bioactive substance contains calcium, P elements and hydroxy.
16. method as claimed in claim 13 is characterized in that, when making this bioactive substance be distributed in this life doctor implant structure top layer and those holes, is to use electrodeposition process, and, comprise phosphonium ion and calcium ion in the employed electrolyte.
17. method as claimed in claim 6 is characterized in that, when carrying out anodising, institute's making alive is between 10 to 90 volts, and the response time is between 5 minutes to 1200 minutes.
18. method as claimed in claim 6, it is characterized in that, with anodising this implant structure is carried out surface treatment when forming a plurality of nanoscale hole, the average diameter size of those hole openings is between 10 to 500nm, the voltage, electric current, response time, reaction temperature, the fluorinion concentration that apply in the time of can be according to anodising are controlled, and the generation direction of those nanoscale holes has single direction.
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| SE536899C2 (en) * | 2012-12-27 | 2014-10-21 | Tigran Technologies Ab Publ | Dental implant unit |
| CN103027740B (en) * | 2013-01-17 | 2014-12-24 | 中奥汇成科技有限公司 | Absorbable bone screw with slow-release biological factor and preparation method thereof |
| CN106637351B (en) * | 2017-01-09 | 2018-08-07 | 佛山市安齿生物科技有限公司 | Be used for colored fixing device of dental implant base station |
| CN114176807B (en) * | 2021-12-08 | 2023-01-24 | 北京航空航天大学 | Multifunctional micro-implant anchorage nail and design and manufacturing method thereof |
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| TW200600122A (en) * | 2004-06-17 | 2006-01-01 | Wen-Ching Say | Biomedical implant comprising sucking nano-hole and a method of preparation thereof |
| WO2006031096A1 (en) * | 2004-09-14 | 2006-03-23 | Oratio B.V. | Method of manufacturing and installing a ceramic dental implant with an aesthetic implant abutment |
| CN1817319A (en) * | 2005-12-26 | 2006-08-16 | 浙江大学 | Production of porous structure with biological activity on surface of pure-titanium tooth implantation |
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