CN102217939A - Micro tip array electrode used for minimally invasive dynamic glucose monitoring - Google Patents
Micro tip array electrode used for minimally invasive dynamic glucose monitoring Download PDFInfo
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- CN102217939A CN102217939A CN 201110138226 CN201110138226A CN102217939A CN 102217939 A CN102217939 A CN 102217939A CN 201110138226 CN201110138226 CN 201110138226 CN 201110138226 A CN201110138226 A CN 201110138226A CN 102217939 A CN102217939 A CN 102217939A
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Abstract
The invention relates to a micro tip array electrode used for minimally invasive dynamic glucose monitoring in the technical field of medical monitoring instruments. The micro tip array electrode comprises a support structure and three electrode structures fixedly connected with the support structure, wherein the electrode structure is composed of an electrode micro tip array and an electrode conduction structure which are connected, and the three electrode conduction structures are all fixedly connected with the support structure. The micro tip array of each electrode in the invention penetrates into and stops at a shallow layer of skin of a human body, and a glucose reaction current in a body fluid can be continuously detected and converted into glucose concentration parameters to be output at regular time, thus minimally invasive continuous glucose monitoring is realized, and the micro tip array electrode has the characteristics of simpleness in operation and slight wound.
Description
Technical field
What the present invention relates to is a kind of device of medical monitoring Instrument technology field, specifically is a kind of micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft.
Background technology
Blood glucose value is the very responsive index that directly reflects interior islet function damage situations of diabetics body and therapeutic effect, so blood sugar monitoring is the key in the treating diabetes.Because the blood sugar for human body level is among the continuous variation, according to the method for external monitoring after the present blood sampling, realize the monitor closely blood sugar level always, must repeatedly take a blood sample every day, give patient's the human body and bring heavy burden mentally.Therefore, the most desirable blood sugar test mode is the dynamic blood sugar monitoring of real-time continuous formula, and sensing electrode continues automatic survey 24 hours every days hundreds of time blood glucose in human body, can understand the situation of change of blood sugar at any time.
Existing dynamic blood glucose sensor adopts three electrode surfaces to apply the biospecific enzymatic structure, its flexible sensitive electrode must be worked in the implant into body, this can produce certain wound to patient itself, and needs the professional to operate, and can cause certain mental pressure to the patient.
Find through retrieval the prior art document, Feng Li etc. are at " Biosensors and Bioelectronics " (" biosensor and bioelectronics " 26,2011,2489 pages-2494 pages) delivered the paper that is entitled as " A selective novel non-enzymeglucose amperometric biosensor based on lectin-sugar binding on thionine modified electrode " (" based on the novel non-enzymatic glucose ampere biosensor of agglutinin sugar ") in conjunction with the thionine modified electrode, propose to adopt dull and stereotyped three-electrode structure, utilize con A and glucose that the bonded principle of biologic specificity takes place on poly-thionine modified electrode and make glucose sensor.This pick off has high sensitivity and high stability, but this electrode can only can collect blood sugar for human body information to take the mode in the whole implant into body of blood sample or electrode.
Summary of the invention
The present invention is directed to the prior art above shortcomings, a kind of micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft is provided, the micro tips array of each electrode of this device thrusts and rests on the shallow top layer of human body skin, can continue to survey in the body fluid blood glucose response electric current and change into the blood sugar concentration parameter and regularly export, thereby realize the monitoring of microtrauma type continuous blood sugar, have characteristics easy and simple to handle, that wound is slight.
The present invention is achieved by the following technical solutions, the present invention includes: supporting construction and three electrode structures of fixedlying connected with it, this electrode structure is made up of the electrode micro tips array and the electrode conducting structure that link to each other, and three electrode conducting structures are all fixedlyed connected with supporting construction.
Described three electrode structures are respectively as working electrode, counter electrode and reference electrode.
Described electrode micro tips array is made up of several little wimble structures and finishing has the electrode function layer.
Described little wimble structure is conical structure or rectangular pyramid structure, and when little wimble structure was conical structure, little wimble structure spacing was greater than the conical structure base diameter, and when little wimble structure was the rectangular pyramid structure, little wimble structure spacing was greater than the cornerwise length in bottom.
The height of described little wimble structure is 20 μ m～200 μ m.
Described electrode conducting structure comprises: contact conductor and contact, wherein: contact conductor connection electrode micro tips array and contact.
Described contact is pick off and the extraneous conduction contact position that is connected.
Three-electrode structure of the present invention can be distributed in the same plane or according to different its relative tertiary locations of design appropriate change.The present invention can be by adjusting quantity, height and the position optimization electrode duty of micro tips array, and the shape of three kinds of conducting structures also can be adjusted arbitrarily.
The present invention makes micro tips array with the MEMS micro fabrication, and micro tips array modified with different functional coatings respectively, form working electrode micro tips array, reference electrode micro tips array, three kinds of different functional areas of counter electrode micro tips array, three kinds of micro tips array have connected and composed the needed three-electrode structure of blood sugar monitoring with corresponding conducting structure respectively.When the present invention worked, the present invention was close to skin, and little spine of each electrode is gone into the superficial tissue liquid layer of human body skin, continue to survey in the body fluid blood glucose response electric current and changed into the blood sugar concentration parameter and regularly export, thereby realize Wicresoft's dynamic monitoring to blood sugar concentration.To conduct electricity that little spine is gone into and the mode of organizing liquid layer that rests on the shallow table of human body replaces the monitoring method of the whole implant into body of conventional dynamic blood sugar monitoring electrode, reduce patient's misery greatly.This electrode need not professional's operation simultaneously, and the patient can independently use, and has increased the feasibility and the generalization of device.The present invention is simple in structure, and monitoring result accurately and reliably.Each electrode micro tips array parallel connection improves the catch probability of monitoring.For the monitoring of the minor fluctuations of blood sugar concentration, this micro tips array electrode has and adds and reach compensating action, has improved monitoring accuracy.The specific surface area of sensor array be can realize adjusting by regulating micro-dimension needle point quantity, thereby reliability and sensitivity improved blood sugar monitoring.Adopt biocompatible material to make entire electrode simultaneously, improved the biocompatibility of electrode and human body.The present invention is fit to integrated production in batches.The present invention adopts micro fabrication, can disposablely produce in enormous quantities, and more traditional blood glucose sensor spare has the feasibility that reduces production costs.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Fig. 2 is embodiment 1 a side-looking structural representation.
Fig. 3 is embodiment 1 structural representation, and wherein: figure (a) is the plan structure sketch map, and figure (b) is little wimble structure sketch map.
Fig. 4 is the structural representation of embodiment 2, and wherein: figure (a) is the plan structure sketch map, and figure (b) is little wimble structure sketch map.
Fig. 5 is the structural representation of embodiment 3.
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated, present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1
As Fig. 1, Fig. 2 and shown in Figure 3, present embodiment comprises: working electrode micro tips array 1, counter electrode micro tips array 2, reference electrode micro tips array 3, working electrode conducting structure 4, counter electrode conducting structure 5, reference electrode conducting structure 6 and supporting construction 7, wherein: working electrode micro tips array 1, counter electrode micro tips array 2 and reference electrode micro tips array 3 respectively with working electrode conducting structure 4, counter electrode conducting structure 5 is connected with reference electrode conducting structure 6, working electrode conducting structure 4, counter electrode conducting structure 5 is all fixedlyed connected with supporting construction 7 with reference electrode conducting structure 6.
Described working electrode micro tips array 1 is made up of and finishing working electrode functional layer several little wimble structures 8.
Described counter electrode micro tips array 2 is made up of and finishing counter electrode functional layer several little wimble structures 8.
Described reference electrode micro tips array 3 is made up of and finishing reference electrode functional layer several little wimble structures 8.
Described little wimble structure 8 is a conical structure.
The base diameter of described conical structure is 10 μ m～300 μ m.
The height of described little wimble structure 8 is 20 μ m～200 μ m, and these little wimble structure 8 spacings are greater than the conical structure base diameter.
Described working electrode conducting structure 4 comprises: working electrode lead-in wire 9 and contact 10, wherein: working electrode lead-in wire 9 is connected with contact 10 with working electrode micro tips array 1 respectively.
Described counter electrode conducting structure 5 comprises: counter electrode lead-in wire 11 and contact 10, wherein: counter electrode lead-in wire 11 is connected with contact 10 with counter electrode micro tips array 2 respectively.
Described reference electrode conducting structure 6 comprises: reference electrode lead-in wire 12 and contact 10, wherein: reference electrode lead-in wire 12 is connected with contact 10 with reference electrode micro tips array 3 respectively.
Described working electrode lead-in wire 9, counter electrode lead-in wire 11 and reference electrode lead-in wire 12 are formed by the joint face 13 that is connected in series successively, straight-arm 14 and vertical linking arm 15, wherein: be respectively equipped with corresponding working electrode micro tips array 1, counter electrode micro tips array 2 and reference electrode micro tips array 3 on the joint face 13, vertical linking arm 15 connects with corresponding contact 10 respectively.
The straight-arm 14 of the straight-arm 14 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is arranged at the both sides of the straight-arm 14 of counter electrode lead-in wire 11 respectively, and the straight-arm 14 of counter electrode lead-in wire 11 is 30 μ m～2mm with the spacing W of the straight-arm 14 of working electrode lead-in wire 9.
The joint face 13 of the joint face 13 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is that ring-type arc and this arc are minor arc.
The joint face 13 of described counter electrode lead-in wire 11 is circular.
The joint face 13 of the joint face 13 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is that congruent figures and two joint faces 13 are symmetrically distributed with the straight line through counter electrode joint face 13 centers of circle.
The spacing L of the joint face 13 of the joint face 13 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is 50 μ m～10mm.
Three kinds of micro tips array 1,2,3 of this device can conduct electricity, and the material of three kinds of micro tips array 1,2,3 is a biocompatible materials.After adopting micro fabrication to utilize the polymer formation micro tips array, three kinds of micro tips array 1,2,3 form tack coat at the device surface sputtered titanium, carry out the mask etching subregion and connected and composed the needed three-electrode structure 16 of blood sugar monitoring, i.e. working electrode structure, reference electrode structure and counter electrode structure with corresponding conducting structure respectively.Each electrode structure is modified, carried out functional differentiation, realize the micro tips array conduction, working electrode functional layer and counter electrode functional layer adopt Pt, and the reference electrode functional layer adopts Ag/AgCl.Working electrode functional layer finishing glucose oxidation catalysts if desired, is further modified semipermeable membrane and screen layer protective layer.
The structural material of described counter electrode lead-in wire 11, reference electrode lead-in wire 12 and working electrode lead-in wire 9 is biocompatible materials.
Described supporting construction 7 adopts biocompatible insulant and has mechanical strength.
Three kinds of micro tips array of this device 1,2,3 thrust and rest on the top layer of human body skin, the degree of depth only reaches organizes liquid layer, extract the enzyme-specific catalyzed chemical reaction information of blood glucose on little sharp electrode in the tissue fluid, and with the output of the form of kinetic current, thereby realize Wicresoft's dynamic monitoring to blood sugar concentration.
As Fig. 1 and as shown in Figure 4, the little wimble structure 8 described in the present embodiment is the rectangular pyramid structure.
The described rectangular pyramid structure base length of side is 10 μ m～300 μ m.
The spacing of described little wimble structure 8 is greater than the cornerwise length in bottom.
As Fig. 1 and as shown in Figure 5, the joint face 13 of the joint face 13 of the lead-in wire of the reference electrode described in the present embodiment 12 and counter electrode lead-in wire 11 is a major arc for ring-type arc and this arc.
The joint face 13 of described working electrode lead-in wire 9 is circular.
The joint face 13 of the joint face 13 of the joint face 13 of described reference electrode lead-in wire 12, counter electrode lead-in wire 11 and working electrode lead-in wire 9 is concentric.
The joint face 13 of described reference electrode lead-in wire 12 is arranged at the outside of the joint face 13 of working electrode lead-in wire 9, and the joint face 13 of counter electrode lead-in wire 11 is arranged at the outside of the joint face 13 of reference electrode lead-in wire 12.
Go between 11 straight-arm 14 conllinear and not overlapping of the straight-arm 14 of described working electrode lead-in wire 9 and counter electrode.
The spacing W of the straight-arm 14 of the straight-arm 14 of described reference electrode lead-in wire 12 and working electrode lead-in wire 9 is 30 μ m～2mm.
Claims (7)
1. micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft, it is characterized in that, comprise: supporting construction and three electrode structures of fixedlying connected with it, this electrode structure is made up of the electrode micro tips array and the electrode conducting structure that link to each other, and three electrode conducting structures are all fixedlyed connected with supporting construction.
2. the micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft according to claim 1 is characterized in that, described three electrode structures are respectively as working electrode, counter electrode and reference electrode.
3. the micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft according to claim 1 is characterized in that, described electrode micro tips array is made up of several little wimble structures and finishing has the electrode function layer.
4. the micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft according to claim 3 is characterized in that, described little wimble structure is conical structure or rectangular pyramid structure.
5. the micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft according to claim 4, it is characterized in that, when described little wimble structure is conical structure, little wimble structure spacing is greater than the conical structure base diameter, when little wimble structure was the rectangular pyramid structure, little wimble structure spacing was greater than the cornerwise length in bottom.
6. according to claim 3 or the 4 or 5 described micro tips array electrodes that are used for the dynamic blood sugar monitoring of Wicresoft, it is characterized in that the height of described little wimble structure is 20 μ m～200 μ m.
7. the micro tips array electrode that is used for the dynamic blood sugar monitoring of Wicresoft according to claim 1 is characterized in that, described electrode conducting structure comprises: contact conductor and contact, wherein: contact conductor connection electrode micro tips array and contact.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110138226 CN102217939B (en) | 2011-05-26 | 2011-05-26 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
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| CN 201110138226 CN102217939B (en) | 2011-05-26 | 2011-05-26 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
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| CN102217939B CN102217939B (en) | 2013-01-09 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105286884A (en) * | 2015-11-05 | 2016-02-03 | 种红侠 | Invasive type blood glucose therapeutic apparatus |
| CN105288774A (en) * | 2015-11-05 | 2016-02-03 | 种红侠 | Application method of invasive type blood glucose therapeutic apparatus |
| CN105517491A (en) * | 2014-10-22 | 2016-04-20 | 深圳市光聚通讯技术开发有限公司 | Continuous glucose monitoring system and monitoring terminal |
| CN109781804A (en) * | 2017-11-10 | 2019-05-21 | 上海瀚联医疗技术股份有限公司 | A kind of blood sugar test module |
| CN109781821A (en) * | 2017-11-10 | 2019-05-21 | 上海瀚联医疗技术股份有限公司 | A kind of blood-sugar detecting instrument |
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| CN1865959A (en) * | 2006-06-01 | 2006-11-22 | 复旦大学 | Electrode array microchip sensor, preparation method and application therefor |
| US20070078376A1 (en) * | 2005-09-30 | 2007-04-05 | Smith Gregory A | Functionalized microneedles transdermal drug delivery systems, devices, and methods |
| WO2008100118A1 (en) * | 2007-02-16 | 2008-08-21 | Cha, Cheol Ung | Biological information measuring apparatus and manufacturing method thereof |
| US20090099427A1 (en) * | 2007-10-12 | 2009-04-16 | Arkal Medical, Inc. | Microneedle array with diverse needle configurations |
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- 2011-05-26 CN CN 201110138226 patent/CN102217939B/en not_active Expired - Fee Related
Patent Citations (4)
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| US20070078376A1 (en) * | 2005-09-30 | 2007-04-05 | Smith Gregory A | Functionalized microneedles transdermal drug delivery systems, devices, and methods |
| CN1865959A (en) * | 2006-06-01 | 2006-11-22 | 复旦大学 | Electrode array microchip sensor, preparation method and application therefor |
| WO2008100118A1 (en) * | 2007-02-16 | 2008-08-21 | Cha, Cheol Ung | Biological information measuring apparatus and manufacturing method thereof |
| US20090099427A1 (en) * | 2007-10-12 | 2009-04-16 | Arkal Medical, Inc. | Microneedle array with diverse needle configurations |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105517491A (en) * | 2014-10-22 | 2016-04-20 | 深圳市光聚通讯技术开发有限公司 | Continuous glucose monitoring system and monitoring terminal |
| WO2016061767A1 (en) * | 2014-10-22 | 2016-04-28 | 深圳市光聚通讯技术开发有限公司 | Continuous glucose monitoring system and monitoring terminal |
| CN105286884A (en) * | 2015-11-05 | 2016-02-03 | 种红侠 | Invasive type blood glucose therapeutic apparatus |
| CN105288774A (en) * | 2015-11-05 | 2016-02-03 | 种红侠 | Application method of invasive type blood glucose therapeutic apparatus |
| CN105963827A (en) * | 2015-11-05 | 2016-09-28 | 彭青 | Invasive type glucose therapeutic apparatus |
| CN109781804A (en) * | 2017-11-10 | 2019-05-21 | 上海瀚联医疗技术股份有限公司 | A kind of blood sugar test module |
| CN109781821A (en) * | 2017-11-10 | 2019-05-21 | 上海瀚联医疗技术股份有限公司 | A kind of blood-sugar detecting instrument |
| CN109781821B (en) * | 2017-11-10 | 2023-10-24 | 上海瀚联医疗技术股份有限公司 | Blood sugar detector |
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