CN102012390A - Wireless multifunctional continuous glucose monitoring system - Google Patents
Wireless multifunctional continuous glucose monitoring system Download PDFInfo
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- CN102012390A CN102012390A CN2010105438758A CN201010543875A CN102012390A CN 102012390 A CN102012390 A CN 102012390A CN 2010105438758 A CN2010105438758 A CN 2010105438758A CN 201010543875 A CN201010543875 A CN 201010543875A CN 102012390 A CN102012390 A CN 102012390A
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Abstract
The invention relates to a wireless multifunctional continuous glucose monitoring system, which comprises a minimally invasive electrochemical glucose sensor, a data acquisition unit, a data processor, a data adaptor and a computer workstation. The minimally invasive electrochemical glucose sensor can be implanted into a tested body in a minimally invasive mode and acquires an electric signal corresponding to a glucose value; the data acquisition unit receives the electric signal acquired by the sensor and converts into a signal which can be analyzed by the data processor and the computer workstation; the data processor receives the signal provided by the data acquisition unit in a wireless transmission mode and analyzes, processes and displays the corresponding information; the data adaptor receives the signal of the data acquisition unit or the data processor in the wireless transmission mode and provides the signal for the computer workstation; and the computer workstation analyzes and processes the data provided by the data adaptor and displays the corresponding information. Each component can be combined through different uses of singly monitoring outpatients, simultaneously observing and clinically monitoring patients and medical care personnel, monitoring a splashes multi-terminal center and the like, the utilization rate of multiplexing equipment is improved, and the repeated cost for purchasing a plurality of equipment for different uses is saved.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly be used for the system of glucose level continuous monitoring.
Background technology
According to the WHO(World Health Organization (WHO)) diabetic's number increases sharply in the statistics global range, and diabetes have become the chronic disease of the 3rd serious harm human health after tumour, cardiovascular and cerebrovascular disease in the world.In the prior art, can adopt two kinds of sample modes of wound and no wound to detect patient's blood glucose value.
China 201010042709.X application for a patent for invention discloses a kind of mobile blood sugar detection method and system, wherein the blood sugar test technology of Cai Yonging is to gather to refer to the classic method (promptly referring to blood formula blood glucose meter) that blood sample is originally tested, and belongs to invasive manner and gathers blood glucose level data.Its defective is, the data that obtain of test are point data sometime, can't realize continuous glucose data monitoring, and interim data (determining according to concrete finger blood testing time) can only be provided, refer to that simultaneously blood formula blood sugar test need puncture the patient and refer to tripe, easily cause the patient suffering.
No. 200910090818.6 applications for a patent for invention of China and 200920172 No. 821.8 utility model patents all disclose a kind of blood sugar real-time monitoring system, wherein the blood sugar monitoring technology of Cai Yonging is to collect blood glucose information in the hypodermis liquid by infrared light transducer[sensor, belongs to no wound mode and collects blood glucose level data.Its defective is, the data instability that adopts infrared light transducer[sensor to gather, and disturbing factor is more, especially easily be subjected to the influence of patient skin color, accuracy rate is not high simultaneously, and infrared light blood sugar test technology does not obtain key breakthrough as yet at present, also fails to enter the practical stage.
Though above-mentioned prior art has exposure that traditional blood glucose monitoring system and wireless network and remote server are used in combination, perhaps combined with radio communication technology, set up the technical scheme that the wireless data between patient and the doctor is got in touch, obtain breakthrough aspect instructing in real time obtaining the doctor, but can't break through the noncontinuity of blood sugar test link itself or the defective of unreliability; In addition, above-mentioned prior art function is simple, can not satisfy the needs of various clinical occasion, is unfavorable for giving full play to medical personnel's specialized guidance technical ability.
Summary of the invention
The invention provides and a kind ofly adopt the patient that not only is fit to of wireless data transmission mode to use separately but also be fit to the other doctor's real-time monitoring of bed needs such as ICU, operation, can realize the loose continuous glucose monitoring system of a hyperchannel center monitoring of hospital simultaneously again.
The object of the invention can be realized by following technical scheme:
The continuous glucose monitoring of a kind of wireless multifunctional system comprises: Wicresoft's electrochemical glucose sensor, can implant detected body in the mode of Wicresoft, and obtain the electric signal corresponding with dextrose equivalent; The described electric signal that data acquisition unit, receiving sensor obtain also is converted into the signal that can supply data processor or computer work to analyze; Data processor receives the signal that data acquisition unit provides by wireless transmission method, and analyzing and processing also shows corresponding information; Data adapter unit receives the signal of data acquisition unit or data processor and offers computer work by wireless transmission method; And computer work, the data that the analyzing and processing data adapter provides also show corresponding information.
Advantage of the present invention: can observe different purposes such as clinical monitoring, diffusing some multiple terminals center monitoring simultaneously according to the monitoring separately of non-inpatient, patient and medical personnel between each ingredient and make up, improve the utilization ratio of multiplexing equipment, save repetition expense because of different purposes buying plurality of devices.Secondly, patent of the present invention has adopted the wireless data transmission mode, has in use increased the convenience that personnel and equipment move, and has improved patient and medical personnel's operability.What the present invention adopted is Wicresoft's electrochemical enzyme electrode monitoring technology, and glucose Electrochemical Measurement Technology accuracy rate height can avoid tradition to refer to that blood formula method of testing needs repeatedly to gather to refer to alleviate the patient suffering by blood on the one hand; On the other hand, can keep a period of time after the enzyme electrode implantation is subcutaneous, and the patient can not feel pain substantially when implanting, after implanting simultaneously, enzyme electrode sensor energy continuous collecting patient tissue liquid glucose data, and be converted to the blood glucose concentration data, its data frequency probably is per minute 1 time, the glucose data of per minute in following 3-4 days can be provided continuously, really realize continuous glucose monitoring.
Description of drawings
The front schematic view of the sensor that Fig. 1 provides for embodiment.
The side schematic view of the sensor that Fig. 2 provides for embodiment.
The structural representation of the data acquisition unit that Fig. 3 provides for embodiment.
The theory diagram of electronic circuit in the data acquisition unit that Fig. 4 provides for embodiment.
The structural representation of the data processor that Fig. 5 provides for embodiment.
The theory diagram of the data processor internal electron circuit that Fig. 6 provides for embodiment.
The structural representation of the data adapter unit that Fig. 7 provides for embodiment.
The theory diagram of the data adapter unit internal electron circuit that Fig. 8 provides for embodiment.
Fig. 9 is that the system of application example one forms synoptic diagram.
Figure 10 is that the system of application example two forms synoptic diagram.
Figure 11 is that the system of application example three forms synoptic diagram.
Embodiment
Referring to Figure 11, the continuous glucose monitoring of the wireless multifunctional that present embodiment provides system comprises: sensor 1, data acquisition unit 2, data processor 3, data adapter unit 4 and computer work 5 specify respectively below in conjunction with accompanying drawing.
The sensor that adopts in the present embodiment is Wicresoft's electrochemical glucose sensor, in conjunction with Figure 1 and Figure 2, comprise plug 11, pedestal 12, probe 13 and adhesive 14 on its structure, probe 13 is arranged on pedestal 12 1 sides, plug 11 is arranged on pedestal 12 opposite sides, be fixed with on the probe 13 can specific detection glucose glucose oxidase or glucose dehydrogenase, be used for detecting the concentration of glucose in the hypodermis liquid, adhesive 14 is arranged on pedestal 12 1 sides (promptly being positioned at homonymy with probe).Sensor can be implanted in the hypodermis wholly or in part, also can tissue fluid be dialysed down from skin by probe transdermal technology, realizes the glucose detection function.
As shown in Figure 3, data acquisition unit is used for directly being connected with sensor, for sensor provides work energy, gathers simultaneously, stores and the glucose information that arrives of wireless transmission sensor, and data acquisition unit is positioned at skin surface or together implants subcutaneous with sensor.Comprise shell 21, sensor socket 22, pilot lamp 23, battery compartment 24 and electronic circuit (electronic circuit is referring to Fig. 4) on this data acquisition unit structure, sensor socket 22 is arranged on shell 21 1 ends, be used for being connected cooperation, thereby provide the electric energy electric signal corresponding that obtain of receiving sensor simultaneously for sensor with dextrose equivalent with the plug 11 of sensor; Pilot lamp 23 is arranged on the shell, is used for the duty of designation data collector; Electronic circuit is arranged in the shell 21, realizes corresponding electric signal processing capacity.As shown in Figure 4, the electronic circuit of data acquisition unit comprises with the lower part: microprocessor, power management module, collection amplification module, A/D modular converter, first crystal oscillator, second crystal oscillator, wireless communication module and battery.Microprocessor is used to control whole data handling procedure, and it has an EEPROM(can wipe memory module) and a SRAM(static store module).EEPROM provides data storage, and SRAM is a system high-speed storage buffer module, temporary transient store sensor data, and data acquisition unit can be stored the data in the longest 4 weeks in the present embodiment.Power management module provides work energy for sensor on the one hand, on the other hand for data acquisition unit provides work energy, and voltage range 0.2-0.7v.Gather size of current between amplification module detecting sensor probe, this size of current is directly proportional with the concentration of glucose size, by a resistance current signal is converted into voltage signal, the micro voltage signal that collects is amplified again.Voltage signal after the A/D modular converter will amplify is converted into manageable corresponding digital signal.First crystal oscillator (not showing among Fig. 4) links to each other with microprocessor, keeps system time.Wireless communication module is given data processor or data adapter unit with the data after the A/D conversion with the frequency emission that is lower than 1 time/minute scarcely.Second crystal oscillator (not showing among Fig. 4) provides lock in time for the transceive data of wireless communication module.Battery (not showing among Fig. 4) is as power supply, as button cell or rechargeable battery.
As shown in Figure 5, data processor comprises shell 31, display screen 32, battery compartment 33, button 34 and electronic circuit (in conjunction with Fig. 6), and display screen 32 and button 34 are arranged on the shell 31, is respectively applied for display message and input data or instruction; Battery compartment is arranged in the shell 31, is used to place battery; Electronic circuit is arranged in the shell 31, realizes corresponding electric signal processing capacity.As shown in Figure 6, the electronic circuit of data processor comprises with the lower part: microprocessor, wireless communication module, first crystal oscillator (not showing among Fig. 6), second crystal oscillator (not showing among Fig. 6), display circuit, input circuit, vibrating motor, hummer, power management module and battery (not showing among Fig. 6).Power management module provides work energy for whole data processor, and battery is as power supply.Microprocessor is as centralized control unit, the operation of control wireless communication module, input circuit, display circuit, hummer and vibrating motor, realize the data handling procedure of whole data processor, it has an EEPROM(can wipe memory module) and a SRAM(static store module), EEPROM provides data storage, but information that storage sensor obtains and sensor current are demarcated and algorithm routine; SRAM is the system high-speed memory buffer unit, and assitance data is handled; Data processor can be stored 10 cases at most in the present embodiment, and every case monitoring time is the longest to reach for 4 weeks.First crystal oscillator links to each other with microprocessor, keeps system time.Second crystal oscillator provides lock in time for the transceive data of wireless communication module.Wireless communication module is responsible for carrying out wireless data transmission with data acquisition unit or data adapter unit.Microprocessor is with the data storage that receives, carry out data analysis and handle, Data Matching module, the data scaling module by software programming, transform the analyzing and processing that function module, sensing data conversion module, data assessment module, judgement of stability module etc. realize data.Button is by input circuit input data and instruction.Display circuit drives the result that display screen will handle by analysis and shows that result displayed can comprise detected glucose collection of illustrative plates and numerical value, and actions menus such as setting, inquiry, and the size of display screen is preferably conveniently carries use.Vibrating motor is used for when satisfying data processor and impose a condition with the mode of vibration prompting or reports to the police.Hummer is used for sounding alarm when satisfying data processor and impose a condition.
As from the foregoing, the function of whole data processor is, regularly receive the data that data acquisition unit sends, the data and the instruction of the input of response input button, be presented on the display screen after data are handled according to specific data processing model, prompting or report to the police when satisfying data processor and impose a condition simultaneously can also be with the data of storage regularly or the disposable data adapter unit that is uploaded to.
As shown in Figure 7, comprise shell 41, USB interface 42, interface cap 43, pilot lamp 44 and electronic circuit (referring to Fig. 8) on the data adapter unit structure, USB interface 42 is arranged on shell 41 1 ends, is used for transmitting with computer data; Pilot lamp 44 is arranged on the shell 41, is used for the duty of indication adapter; Electronic circuit is arranged on shell 41 inside, realizes corresponding electric signal processing capacity.As shown in Figure 8, the electronic circuit of data adapter unit comprises with the lower part: microprocessor, wireless communication module, indicator light circuit, memory module, first crystal oscillator, second crystal oscillator.Microprocessor control wireless communication module regularly or disposable reception data acquisition unit or the data processor data or the instruction of sending also can be with the instruction of computer work by passing to data processor or data acquisition unit under the wireless communication module.Memory module is used for temporarily storing the data that wireless communication module receives.First crystal oscillator provides clock for microprocessor, and second crystal oscillator provides lock in time for the wireless module transceive data.Generally, the function of data adapter unit is: computer work is handed in data or instruction that data acquisition unit or data processor send, also passed to data processor or data acquisition unit under the instruction with computer work.
The function of computer work is to receive the data from data acquisition unit or data processor that data adapter unit is transmitted, data are handled, shown and add up according to specific data processing model, receive the information of input simultaneously, also can send instruction data collector or data processor.Content displayed comprises precession diagram, multiple fractal collection of illustrative plates, blood glucose fluctuation situation, multiple average blood sugar value, hypoglycemia time ratio, hyperglycaemia time ratio, euglycemia time ratio, blood glucose value, postprandial plasma glucose level, setting period blood glucose value etc. before the meal.The screen size of computer work is clearly seen the patient information that shows on the screen to make things convenient for medical personnel in that long distance is interior.
In the present embodiment, sensor is connected by connector with data acquisition unit, also can integratedly prepare; Adopt wireless data transmission mode, transmission range 1m～200m each other between data acquisition unit and data processor or the data adapter unit; Be connected by USB interface or data line between data adapter unit and the computer work.
The present invention adopts probe-type electrochemical glucose sensor, during use probe sensor inserted patient's hypodermis, contact with the hypodermis interstitial fluid, micro-glucose molecule in the interstitial fluid contacts with the glucose oxidase of detecting probe surface and reacts, produce electric signal, electric signal is received and is delivered to data acquisition unit and data processor by electrode, data processor is according to the relation of electric signal and blood glucose concentration, go out corresponding concentration of glucose through specific algorithm computation, thereby finish the collection of concentration of glucose data.
During actual the use, can sensor, data acquisition unit, data processor combination use alone for single patient; Also can sensor, data acquisition unit, data adapter unit, computer work combination monitor use face to face for medical personnel and patient; Can also a plurality of paired sensors, data acquisition unit, data processor (can not have), data adapter unit (a plurality of or one), a computer work form jointly for a multi-user and hold the center monitoring network to use, medical personnel can understand patient's situation of different local a plurality of terminals in real time in Surveillance center.Enumerate several examples of application below:
Example one
As shown in Figure 9, system is made up of sensor 1, data acquisition unit 2, data processor 3, and the patient can leave hospital and use.The glucose information that sensor 1 detects in the hypodermis, the detected information of data acquisition unit 2 pick-up transducers, and 1 time/minute send to data processor 3, data processor 3 per minutes receive the data that data acquisition unit 2 sends, data are handled back per minute update displayed on display screen according to specific data processing model, and display screen can singly shield and show 2～12 hours precession diagrams and current dextrose equivalent.Also can turn over screen and show per 2～12 hours all one section precession diagrams, dextrose equivalent with per minute, with continuous monitoring patient glucose, the patient can take measures with self-control of blood sugar in target zone by collection of illustrative plates, data and the prompting that shows, the information of warning.
Example two
On the basis of example 1, add data adapter unit 4 and computer work 5 in the system.Patient-monitoring after a period of time or monitoring can at any time the data that are stored in the data processor 3 be downloaded in the computer work 5 by data adapter unit 4 after finishing fully, obtain various detailed blood sugar figure and statistics tables, and offer the professional health care worker, with more science overall understanding and assessment blood glucose condition.
Example three
As shown in figure 10, system is made up of sensor 1, data acquisition unit 2, data adapter unit 4 and computer work 5, the glucose information that sensor 1 detects in the hypodermis, the detected information of data acquisition unit 2 pick-up transducers, and 1 time/minute send to data adapter unit 4, data adapter unit 4 is given computer work 5 with data upload, computer work 5 is handled back per minute update displayed with data on display screen according to specific data processing model, and display screen can show from beginning to detect precession diagram and the current blood glucose value to current time random time section.Also can show from beginning to detect various detailed blood sugar figure and statistics tables to the current time,, understand patient's blood glucose condition in real time, be convenient to take at once therapeutic scheme, use when mainly being applicable to operation for the professional health care worker.
Example four
As shown in figure 11, system is made up of many groups sensor 1, data acquisition unit 2, data processor 3, a data adapter unit 4 and a computer work 5, the multidigit patient's data can the simultaneously real-time computer work that is presented at a far-end on, medical personnel can monitor multidigit patient's blood sugar situation in real time an office.
Monitoring system provided by the invention, employing be Wicresoft's electrochemical enzyme electrode monitoring technology, glucose Electrochemical Measurement Technology accuracy rate height can avoid on the one hand tradition to refer to that blood formula method of testing needs repeatedly to gather to refer to alleviate the patient suffering by blood; On the other hand, can keep a period of time after the enzyme electrode implantation is subcutaneous, and the patient can not feel pain substantially when implanting, after implanting simultaneously, enzyme electrode sensor energy continuous collecting patient tissue liquid glucose data, and be converted to the blood glucose concentration data, its data frequency probably is per minute 1 time, the glucose data of per minute in following 3-4 days can be provided continuously, really realize continuous glucose monitoring.
Claims (8)
1. the continuous glucose monitoring of wireless multifunctional system comprises: Wicresoft's electrochemical glucose sensor, can implant detected body in the mode of Wicresoft, and obtain the electric signal corresponding with dextrose equivalent; The described electric signal that data acquisition unit, receiving sensor obtain also is converted into the signal that can supply data processor or computer work to analyze; Data processor, by the signal that wireless transmission method reception data acquisition unit or data processor provide, analyzing and processing also shows corresponding information; Data adapter unit receives the signal of data acquisition unit or data processor and offers computer work by wireless transmission method; And computer work, the data that the analyzing and processing data adapter provides also show corresponding information.
2. the continuous glucose monitoring of wireless multifunctional according to claim 1 system, it is characterized in that: described Wicresoft electrochemical glucose sensor comprises plug, pedestal, probe and adhesive, probe is arranged on pedestal one side, plug is arranged on the pedestal opposite side, be fixed with on the probe can specific detection glucose glucose oxidase or glucose dehydrogenase, be used for detecting the concentration of glucose in the hypodermis liquid, adhesive is arranged on pedestal one side, is positioned at homonymy with probe.
3. the continuous glucose monitoring of wireless multifunctional according to claim 2 system, it is characterized in that: described data acquisition unit comprises shell, sensor socket, pilot lamp, battery compartment and electronic circuit, sensor socket is arranged on shell one end, be used for being connected cooperation, for sensor provides the electric energy electric signal corresponding with dextrose equivalent that obtain of receiving sensor simultaneously with the plug of described sensor; Pilot lamp is arranged on the shell, is used for the duty of designation data collector; The electronic circuit setting realizes the electric signal processing capacity in the enclosure.
4. the continuous glucose monitoring of wireless multifunctional according to claim 3 system, it is characterized in that: the electronic circuit of described data acquisition unit comprises: microprocessor, power management module, collection amplification module, A/D modular converter, first crystal oscillator, second crystal oscillator, wireless communication module and battery; Microprocessor is used to control whole data handling procedure, and it has an EEPROM and a SRAM; Power management module provides work energy for sensor on the one hand, provides work energy for data acquisition unit on the other hand; Gather size of current between amplification module detecting sensor probe, and current signal is converted into voltage signal, again the micro voltage signal that collects is amplified; Voltage signal after the A/D modular converter will amplify is converted into manageable corresponding digital signal; First crystal oscillator links to each other with microprocessor, keeps system time; Data after wireless communication module is changed A/D send to data processor or data adapter unit; Second crystal oscillator provides lock in time for the transceive data of wireless communication module; Battery is as power supply.
5. the continuous glucose monitoring of wireless multifunctional according to claim 4 system, it is characterized in that: described data processor comprises shell, display screen, battery compartment, button and electronic circuit; Display screen and button are arranged on the shell, are respectively applied for display message and input data or instruction; The battery compartment setting is used to place battery in the enclosure; The electronic circuit setting realizes the electric signal processing capacity in the enclosure.
6. the continuous glucose monitoring of wireless multifunctional according to claim 5 system, it is characterized in that: the electronic circuit of described data processor comprises: microprocessor, wireless communication module, first crystal oscillator, second crystal oscillator, display circuit, input circuit, vibrating motor, hummer, power management module and battery; Power management module provides work energy for whole data processor, and battery is as power supply; The operation of microprocessor control wireless communication module, input circuit, display circuit, hummer and vibrating motor; First crystal oscillator links to each other with microprocessor, keeps system time; Second crystal oscillator provides lock in time for the transceive data of wireless communication module; Wireless communication module is responsible for carrying out wireless data transmission with data acquisition unit or data adapter unit; Microprocessor carries out the data storage that receives data analysis and handles; Input circuit is used for button input data and instruction; Display circuit drives result's demonstration that display screen will be handled by analysis; Vibrating motor and hummer are used for pointing out with vibration or buzzing mode when satisfying data processor and impose a condition or reporting to the police.
7. the continuous glucose monitoring of wireless multifunctional according to claim 6 system, it is characterized in that: comprise shell, USB interface, interface cap, pilot lamp and electronic circuit on the described data adapter unit structure, USB interface is arranged on shell one end, is used for transmitting with computer data; Pilot lamp is arranged on the shell, is used for the duty of indication adapter; Electronic circuit is arranged on enclosure, realizes corresponding electric signal processing capacity.
8. the continuous glucose monitoring of wireless multifunctional according to claim 7 system, it is characterized in that: the electronic circuit of described data adapter unit comprises with the lower part: microprocessor, wireless communication module, indicator light circuit, memory module, first crystal oscillator and second crystal oscillator; Microprocessor control wireless communication module regularly or disposable reception data acquisition unit or the data processor data or the instruction of sending also can be with the instruction of computer work by passing to data processor or data acquisition unit under the wireless communication module; Memory module is used for temporarily storing the data that wireless communication module receives; First crystal oscillator provides clock for microprocessor, and second crystal oscillator provides lock in time for the wireless module transceive data.
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| CN108120794A (en) * | 2017-12-21 | 2018-06-05 | 深圳市赛亿科技开发有限公司 | A kind of method of concentration of glucose in Intelligent cup and its detection beverage |
| WO2021215343A1 (en) * | 2020-04-21 | 2021-10-28 | 株式会社村田製作所 | Conversion adapter |
| EP4104751A4 (en) * | 2020-04-21 | 2024-02-28 | Murata Manufacturing Co | Conversion adapter |
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Application publication date: 20110413 |