CN101972146A - Self-feedback assisted method for breathing signal in cardiovascular magnetic resonance imaging - Google Patents
Self-feedback assisted method for breathing signal in cardiovascular magnetic resonance imaging Download PDFInfo
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- CN101972146A CN101972146A CN2010102730316A CN201010273031A CN101972146A CN 101972146 A CN101972146 A CN 101972146A CN 2010102730316 A CN2010102730316 A CN 2010102730316A CN 201010273031 A CN201010273031 A CN 201010273031A CN 101972146 A CN101972146 A CN 101972146A
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Abstract
The invention relates to a self-feedback assisted method for a breathing signal in cardiovascular magnetic resonance imaging, which comprises the following steps of: 1) converting a pneumatic signal of an abdominal breathing induced band bound to a subject into a voltage signal through a pressure sensor; 2) performing gain amplification processing on an electric signal output by the pressure sensor through a gain amplifier; 3) converting the electric signal subjected to the gain amplification processing into a digital signal through an analog signal digital sampling module, and outputting the sampled data; 4) denoising the sampled data through a data processing module, and calculating a mean value; and 5) finally outputting navigation waves through a display module. The method can realize self-feedback breathing navigation gate control-based improved magnetic resonance whole-heart coronary artery imaging.
Description
Technical field
The present invention relates to the association area of medical apparatus and instruments, the self feed back householder method of breath signal in particularly a kind of cardiovascular magnetic resonance imaging is particularly useful in the higher magnetic resonance coronary imaging of the stability requirement of breathing.
Background technology
Coronary heart disease is the major disease of harm humans health, and annual consequent medical expense is crossed hundred billion yuans, brings heavy financial burden to the country and people.The cardiovascular diseases has become urgent day by day great social common problem, if can not effectively prevent and treat it, will have influence on the comprehensive raising and the high speed development of national economy of people ' s health quality.Seek the aspects such as early diagnosis, risk stratification, treatment decision-making and therapeutic evaluation of the method for a kind of real noinvasive, no X ray, play crucial effect in coronary heart disease.
(magnetic resonance imaging, clinical practice MRI) is increasingly extensive, plays an increasingly important role in coronary heart disease diagnosis, and the diagnosis of diseases such as congenital heart disease, cardiomyopathy is had irreplaceable value in nuclear magnetic resonance.Because the MRI imaging time is longer relatively, cardiovascular MRI picture quality often is subjected to the influence of the pseudo-shadow of respiratory movement.Can therefore, how to reduce the pseudo-shadow influence of respiratory movement effectively be the necessary guarantee that make correct diagnosis.There is the scholar to propose in cardiovascular MRI by the pseudo-shadow of inhibition respiratory movement of repeatedly holding one's breath, radio-frequency pulse excites with signals collecting and only carries out mutually holding one's breath, the appearance of this technology has reduced the pseudo-shadow of respiratory movement of conventional cardiovascular MRI image effectively, therefore is widely used clinical.Because coronary artery has characteristics such as caliber is tiny, traveling is tortuous, so the coronary imaging required time is longer, the method for holding one's breath can not be finished scanning smoothly.
The end of the nineties, there is the scholar to propose to adopt freely to breathe airmanship and finishes CMRA, in whole checking process, the subjects freely breathes, by perspective navigation ripple the diaphram position is monitored in real time, through predefined correction factor cardiac position is proofreaied and correct in real time again, finished image reconstruction on this basis.Breathe the application of airmanship, increased subjects's compliance, also enlarged the coverage of imaging.But major defect is, because only carry out image acquisition in the breathing cycle mutually when specific, so its required review time is longer; If the patient is inhomogeneous in relatively long time internal respiration, frequently change respiratory frequency, causes easily that then navigation decrease in efficiency, acquisition time prolong, picture quality reduces even check failure.Therefore, tradition is breathed airmanship becomes the main bottleneck of restriction MRI in the coronary imaging wide clinical application.
During conventional CMRA checked, the experimenter lay on the magnetic resonance sick bed, and in the time of magnetic resonance imaging system scanning, the experimenter does not accept any feedback information, can not know own respiratory frequency and amplitude situation in the checking process.If adopt the radio shielding optical projection system to give the breathing navigation waveform of the real-time projection of experimenter oneself, provide a feedback platform for its autonomous breathing pattern of adjusting, can improve and breathe navigation efficient, be beneficial to and finish inspection within a short period of time.In this process, as only the navigation of the breathing on machine operation interface oscillogram directly being fed back to the experimenter, before often needing to check it is trained up, usually there is certain difficulty in this for the lower patient of schooling at advanced age, and, the patient can not cooperate on the contrary well sometimes for anxiety.
Summary of the invention
The objective of the invention is to, the self feed back householder method of breath signal in a kind of cardiovascular magnetic resonance imaging is provided.
For achieving the above object, the self feed back householder method of breath signal in a kind of cardiovascular magnetic resonance imaging of the present invention, the method comprising the steps of:
1) converts bondage to voltage signal in the air pressure signal of experimenter's abdominal respiration induction band by pressure transducer;
2) by gain amplifier to the signal of telecommunication of the pressure transducer output processing and amplifying that gains;
3) will gain after electrical signal conversion after the processing and amplifying becomes digital signal the output sampled data again by the analog signal figure sampling module;
4) by data processing module sampled data is carried out denoising, calculating mean value again;
5) final, via display module output navigation ripple.
As a kind of improvement of technique scheme, described gain amplifier adopts programmable gain amplifier, is used to be provided with from 0.5～16 with 2 integral number power increase progressively.When different ADC input voltage signal range differences when maybe needing to amplify the signal with big direct current offset greatly, programmable gain amplifier is very useful.
As another improvement of technique scheme, the sample frequency of described analog signal figure sampling module is 100KHz.
As another improvement of technique scheme, described denoising is removed several maximums and minima in the sampled data for after repeatedly sampling.
Improve as the another kind of technique scheme, in the described step 5), the binary data that display module will receive in real time is reduced into corresponding sampled value and is presented on the navigator window with the form of navigation ripple; And this navigator window also shows one and breathes the navigation band, the amplitude of respiration scope that this breathing navigation band sets for nuclear magnetic resonance scanning.
Another kind as technique scheme improves, and described pressure transducer adopts piezoresistive silicon sensor.
Another kind as technique scheme improves, and described piezoresistive silicon sensor is half responsive electric bridge piezoresistive silicon sensor or full-bridge piezoresistive silicon sensor.
Another kind as technique scheme improves, and the self feed back householder method of described breath signal also comprises the step of storage: by memory module storage breath signal, think that respiratory training and magnetic resonance navigation provides reference data.
The invention has the advantages that the self feed back householder method of breath signal in the cardiovascular magnetic resonance imaging of the present invention can realize breathing improvement magnetic resonance coronary imaging whole-heartedly under the navigation based on self feed back.
The present invention can be based on breathing the coronary artery MR imaging that the navigation signal self feed back is adjusted in real time.When tradition was breathed airmanship MR imaging, the patient can not be known own respiratory frequency and amplitude situation, for free breathing state completely.Adopt the radio shielding optical projection system to feed back amplitude of respiration and frequency change situation in real time for the patient, make the patient can be from main regulation amplitude of respiration and frequency in checking process, initiative prolongs the relative plateau of end-tidal, thereby finishes the body magnetic resonant imaging examination fast.In addition, because it is comparatively complicated, not directly perceived to breathe navigation signal, therefore directly this signal feedback is given the experimenter beyond affordability and finish autonomous adjustment.Therefore, after the present invention realizes by exploitation interactive entertainment interface software, carry out respiratory training before checking for the experimenter and check in carry out amplitude of respiration and respiratory frequency adjustment in real time.In this system, to breathe the navigation shape information and adopt conventional means also can be converted to the interactivity interface, this makes the patient finish training by interface adjustment self amplitude of respiration easily.
Of the present inventionly breathe magnetic resonance aspects such as the non-invasive early diagnosis that is applied in coronary heart disease, risk stratification, treatment decision-making and therapeutic evaluation of coronary imaging method whole-heartedly under the navigation, will play crucial effect based on self feed back.
Description of drawings
Fig. 1 is the schematic flow sheet of the self feed back householder method of breath signal in the cardiovascular magnetic resonance imaging of the present invention;
Fig. 2 a is the sketch map of the full-bridge piezoresistive silicon sensor in one embodiment of the invention;
Fig. 2 b is the sketch map of half responsive electric bridge piezoresistive silicon sensor in one embodiment of the invention.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, structure of the present invention is described in more detail.
As shown in Figure 1, adopt the self feed back householder method of breath signal in the cardiovascular magnetic resonance imaging of the present invention, to breathe induction band bondage and experimenter's abdominal part, air pressure signal is after pressure transducer converts voltage signal to, carry out automatic gain control by gain amplifier, carry out digital sample by the analog signal figure sampling module again, again sampled data is handled: denoising, calculating mean value; At last, by serial ports output, promptly by after the binary coding data being exported by serial ports.
The reduction and the increase of corresponding pressure when pressure transducer can adopt piezoresistive silicon sensor (PRT) monitoring suction and exhalation.
PRT generally is configured to a Wheatstone bridge closely.When being applied to the responsive electric bridge of PRT, (sees shown in Fig. 2 a) pressure that the change of equidirectional, identical size will take place the resistance value of diagonal angle brachium pontis.When increasing under two effects of resistance value at pressure on the diagonal angle brachium pontis, the resistance value of another one diagonal angle brachium pontis reduces, and vice versa.For half responsive electric bridge PRT (seeing shown in Fig. 2 b), then have only the resistance value of half of brachium pontis to change.No matter be the full-bridge or the PRT pick off of half responsive electric bridge all have high sensitivity (＞10mv/v), favorable linearity and advantages such as temperature stability, no signal hysteresis, its measuring range can go up to the destructive limit.
In this example, the MPXV10GC6U that pressure transducer adopts Freescale company to produce, technical parameter: 0 to 10kPa (0 to 1.45psi) 35mV gamut.
The interior gain control module of the C8051F124 sheet of Silicon Laboratories is adopted in automatic gain control; Programmable gain amplifier gain can with software setting from 0.5 to 16 with 2 integral number power increase progressively when different ADC input voltage signal range differences programmable gain amplifier when maybe needing to amplify the signal with direct current offset greatly greatly be very useful.
The analog signal figure sampling module adopts interior 12 the ADC modules of the C8051F124 sheet of Silicon Laboratories.Sample frequency: 100KHz.
Sampled data is handled, denoising, calculating mean value.Wherein, denoising: repeatedly after the sampling, remove several maximums and minima in the sampled data.Calculating mean value:, obtain the repeatedly meansigma methods of sampling with the data computation meansigma methods after the denoising.Then, export through serial ports: after by binary coding data are exported by serial ports.
At last, display module is realized the serial equipment autoconnect function, and the binary data that will receive in real time is reduced into corresponding sampled value and is presented on the navigator window with the form of navigation ripple.And the display terminal synchronized transmission sampled data on far-end network, the show navigator ripple synchronously of the computer on the far-end network like this.
Computer software is accepted data show navigation ripple: computer software is realized the serial equipment autoconnect function, and the binary data that will receive in real time is reduced into corresponding sampled value and is presented on the navigator window with the form of navigation ripple.And the display terminal synchronized transmission sampled data on far-end network, the show navigator ripple synchronously of the computer on the far-end network like this.
In the practical application, the experimenter breathes the synchronous navigation ripple signal that produces by watching oneself, adjusts amplitude of respiration, the end-tidal signal just in time is presented at breathes in the navigation band.Breathe the amplitude of respiration scope that the navigation band sets for nuclear magnetic resonance scanning.So just can realize stable periodic scan.
Simultaneously can also realize the respiratory training function of experimenter before scanning, the experimenter is finished before the body magnetic resonance examination carry out interactive breathing pattern training, obtain individual specificity's best breathing pattern; By native system individuality is breathed navigation ripple signal and feed back to the experimenter in real time in the body magnetic resonance examination, make the experimenter can adjust self amplitude of respiration and respiratory frequency in real time in inspection, high-quality is finished the body magnetic resonance examination.
It should be noted last that above embodiment is only unrestricted in order to technical scheme of the present invention to be described.Although the present invention is had been described in detail with reference to embodiment, those of ordinary skill in the art is to be understood that, technical scheme of the present invention is made amendment or is equal to replacement, do not break away from the spirit and scope of technical solution of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (8)
1. the self feed back householder method of breath signal in the cardiovascular magnetic resonance imaging, the method comprising the steps of:
1) converts bondage to voltage signal in the air pressure signal of experimenter's abdominal respiration induction band by pressure transducer;
2) by gain amplifier to the signal of telecommunication of the pressure transducer output processing and amplifying that gains;
3) will gain after electrical signal conversion after the processing and amplifying becomes digital signal the output sampled data again by the analog signal figure sampling module;
4) by data processing module sampled data is carried out denoising, calculating mean value again;
5) final, via display module output navigation ripple.
2. the self feed back householder method of breath signal is characterized in that in the cardiovascular magnetic resonance imaging according to claim 1, and described gain amplifier adopts programmable gain amplifier, is used to be provided with from 0.5～16 with 2 integral number power increase progressively.
3. the self feed back householder method of breath signal is characterized in that in the cardiovascular magnetic resonance imaging according to claim 1, and the sample frequency of described analog signal figure sampling module is 100KHz.
4. the self feed back householder method of breath signal is characterized in that in the cardiovascular magnetic resonance imaging according to claim 1, and described denoising is removed several maximums and minima in the sampled data for after repeatedly sampling.
5. the self feed back householder method of breath signal in the cardiovascular magnetic resonance imaging according to claim 1, it is characterized in that, in the described step 5), the binary data that display module will receive in real time is reduced into corresponding sampled value and is presented on the navigator window with the form of navigation ripple; And this navigator window also shows one and breathes the navigation band, the amplitude of respiration scope that this breathing navigation band sets for nuclear magnetic resonance scanning.
6. the self feed back householder method of breath signal is characterized in that in the cardiovascular magnetic resonance imaging according to claim 1, and described pressure transducer adopts piezoresistive silicon sensor.
7. the self feed back householder method of breath signal is characterized in that in the cardiovascular magnetic resonance imaging according to claim 1, and described piezoresistive silicon sensor is half responsive electric bridge piezoresistive silicon sensor or full-bridge piezoresistive silicon sensor.
8. the self feed back householder method of breath signal in the cardiovascular magnetic resonance imaging according to claim 1, it is characterized in that, the self feed back householder method of described breath signal also comprises the step of storage: the storage breath signal, think that respiratory training and magnetic resonance navigation provides reference data.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103280145A (en) * | 2013-05-03 | 2013-09-04 | 上海交通大学 | Cardiovascular interventional virtual surgery force-feedback system |
| CN106204677A (en) * | 2016-07-14 | 2016-12-07 | 北京大学 | A kind of device improving Dynamic constrasted enhancement magnetic resonance image (MRI) temporal resolution |
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| JP2004049797A (en) * | 2002-07-24 | 2004-02-19 | Anzai Medical Kk | Belt for fixing breathing state detection sensor |
| CN1742671A (en) * | 2005-07-21 | 2006-03-08 | 高春平 | Biological feed-back device with prompting and breathing-imitating function |
| CN101259020A (en) * | 2007-01-22 | 2008-09-10 | Ge医疗系统环球技术有限公司 | MRI apparatus |
| US20080243018A1 (en) * | 2007-03-30 | 2008-10-02 | General Electric Company | System and method to track a respiratory cycle of a subject |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004049797A (en) * | 2002-07-24 | 2004-02-19 | Anzai Medical Kk | Belt for fixing breathing state detection sensor |
| CN1742671A (en) * | 2005-07-21 | 2006-03-08 | 高春平 | Biological feed-back device with prompting and breathing-imitating function |
| CN101259020A (en) * | 2007-01-22 | 2008-09-10 | Ge医疗系统环球技术有限公司 | MRI apparatus |
| US20080243018A1 (en) * | 2007-03-30 | 2008-10-02 | General Electric Company | System and method to track a respiratory cycle of a subject |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103280145A (en) * | 2013-05-03 | 2013-09-04 | 上海交通大学 | Cardiovascular interventional virtual surgery force-feedback system |
| CN103280145B (en) * | 2013-05-03 | 2016-01-13 | 上海交通大学 | Cardiovascular intervention virtual operation force feedback system |
| CN106204677A (en) * | 2016-07-14 | 2016-12-07 | 北京大学 | A kind of device improving Dynamic constrasted enhancement magnetic resonance image (MRI) temporal resolution |
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Application publication date: 20110216 Assignee: Beijing Siruixing Technology Co.,Ltd. Assignor: XUANWU HOSPITAL OF CAPITAL MEDICAL University Contract record no.: 2019990000177 Denomination of invention: Self-feedback assisted method for breathing signal in cardiovascular magnetic resonance imaging Granted publication date: 20111123 License type: Common License Record date: 20190531 |
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Granted publication date: 20111123 Termination date: 20210903 |