CN101900704A - Method for improving blood measuring accuracy by insertion algorithm - Google Patents
Method for improving blood measuring accuracy by insertion algorithm Download PDFInfo
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- CN101900704A CN101900704A CN 201010238647 CN201010238647A CN101900704A CN 101900704 A CN101900704 A CN 101900704A CN 201010238647 CN201010238647 CN 201010238647 CN 201010238647 A CN201010238647 A CN 201010238647A CN 101900704 A CN101900704 A CN 101900704A
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Abstract
The invention provides a method for improving blood measuring accuracy by an insertion algorithm, which is characterized by comprising the following steps: carrying out laboratory calibration on a dripping test strip plug-in circuit to obtain a corresponding output voltage value for the plug-in circuit of each standard blood parameter concentration value among n standard blood parameter concentration values at m different temperature spots, obtaining n*m testing and calibrating points according to the voltage values, expressing the blood parameter concentration values as G(i, j) and the output voltage values as U(i, j), and storing U(i, j), G(i, j) and an insertion algorithm program in a digital processing system connected with the dripping test strip plug-in circuit; and when the dripping test strip plug-in circuit measures that the output voltage values U do not accord with the testing and calibrating points U(i, j), using the insertion algorithm to calculate a blood parameter concentration value G according to two testing and calibrating points G(i, j) corresponding to two testing and calibrating points U(i, j) adjacent to the measured output voltage values U.
Description
Technical field
The present invention relates to the blood measuring technology, particularly a kind of method of utilizing insertion algorithm to improve blood measuring accuracy.Described method can be applied to glucometer, blood ketone measuring instrument, and the blood fat measuring instrument, the cholesterol measuring instrument, thus improve blood measuring accuracy.Described blood measuring adopts the strip (also claiming blood measuring strip or test paper) of bleeding, and the strip of bleeding of standard has blood glucose measurement strip, blood ketone to measure strip, blood fat is measured strip, cholesterol measurement strip or the like.
Background technology
For convenience of explanation, let us says something with blood glucose meter.In fact, for other instruments that detects blood, principle is also basic identical.
Improve accuracy and will reduce error as far as possible.The flow process that blood glucose meter is measured blood is, the blood sugar in the oxidase of the test paper contact blood and produce electric current at first, electric current becomes voltage, again through amplification, conversion, be blood sugar numerical value by voltage transitions more at last, be presented on the screen and preserve.To final voltage, become the blood sugar numerical value of demonstration by the blood sugar numerical transformation on the test paper again by final voltage transformation.At last the blood sugar numerical value of Xian Shiing must with test paper truly measure consistent.If inconsistent, there is error exactly.
The error of portable glucose meter is mainly derived from blood glucose meter itself and test paper two aspects.The error that whole blood glucose meter is measured is the stack of the two, and these two kinds of errors all need to reduce.Reduce the test paper error, key is to guarantee the consistance of same batch of every test paper, just requires the measuring blood function of same batch of test paper identical.This is the problem of the design and the manufacturing of test paper.This problem is solved by the design of test paper, and we wouldn't discuss in the present invention, waits until from now on solving.The present invention only discusses the error of blood glucose meter itself and reduces the method for these errors.The software and hardware problem of blood glucose meter design itself just only is discussed and is reduced their error problem.
So here, we think that same batch the performance of test paper is identical.Before a collection of test paper dispatched from the factory, we can under lab demarcate.
The principle of work of blood glucose meter in the prior art: behind test paper insertion blood glucose meter testing jack, be known as G with concentration of glucose
1Test droplets on (or being put on) test paper, so the other end produces electric current, after the amplification calculation process through the blood glucose meter circuit, can output voltage U
1Because blood sugar G
1Produce voltage U 1 at experimental determination, conversely, we just can determine, when detecting for the patient, are U1 if measure output voltage, and we can think that its blood sugar concentration of generation promptly is G
1So, just can on screen, show G
1
In fact, different output voltages is just corresponding to different blood sugar numerical value.Here, a relation curve is arranged between output voltage and the tested blood sugar, promptly is voltage-blood sugar relation curve, and this curve reflects between output voltage and the tested blood glucose value and concerns, output voltage has been arranged, just can find pairing blood sugar numerical value from this voltage-blood sugar relation curve.
This voltage-blood glucose curve should be an empirical curve.Demarcate with the corresponding voltage of measuring and draw by testing blood sugar accurately in the laboratory.When using blood glucose meter, blood glucose meter converts blood sugar numerical value by the voltage that draws automatically to according to curve and shows then.If just on some test points, if the circuit of blood glucose meter does not cause other errors, this result should be accurately to the magnitude of voltage of measuring.
Is but the number of test point limited, how according to the data of these test points whole piece voltage-blood sugar relation curve that draws? the blood glucose meter deviser at present adopts a polynomial curve to approach this empirical curve.Generally getting 3 order polynomials approaches.Promptly get:
Y＝A
3X
3+A
2X
2+A
1X+A
0
A wherein
0, A
1, A
2, A
3, be given constant, by the experiment decision.To the test paper of different batches, different A is arranged
0, A
1, A
2, A
3, constant.But it is not accurate enough only replacing real empirical curve with the curve that 4 parameters are arranged, and has only 4 points can determine accurately.Other points cause error unavoidably.This is an important source of blood glucose meter error.
The another one source of error is a temperature error.Oxidase on the test paper can produce electric current after running into blood sugar, but the size of generation electric current is temperature-dependent.So, when the electric current that is produced by blood glucose meter is calculated blood sugar numerical value conversely, also to consider Temperature Influence.The method of at present general blood glucose meter is to establish a temperature correction facotor K, and K is generally between 0.7 to 1.3.When measuring blood, behind voltage derivation blood sugar numerical value, multiply by this temperature correction facotor again, be only the last blood sugar numerical value that goes out (also can multiply by COEFFICIENT K earlier, remove to look into pairing blood sugar numerical value again) measuring voltage.Under same temperature, different voltages are all adopted this same COEFFICIENT K, be a simple bearing calibration, cause error unavoidably.But concerning present blood glucose meter on the market, main error will correct by hardware circuit design, can accomplish this point, and this has been not easy.
Summary of the invention
The present invention is directed to the defective or the deficiency that exist in the prior art, a kind of method of utilizing insertion algorithm to improve blood measuring accuracy is provided.Described method can be applied to glucometer, blood ketone measuring instrument, and the blood fat measuring instrument, the cholesterol measuring instrument, thus improve blood measuring accuracy.Described blood measuring adopts the strip (also claiming blood measuring strip or test paper) of bleeding, the strip of bleeding of standard has blood glucose measurement strip, blood ketone to measure strip, blood fat is measured strip, cholesterol measurement strip or the like, and strip obtains corresponding blood parameters concentration value with the digital processing system that is connected with its circuit by bleeding.
Technical scheme of the present invention is as follows:
Utilize insertion algorithm to improve the method for blood measuring accuracy, it is characterized in that, comprise the strip plug-in unit circuit chamber of experimentizing of bleeding is demarcated, obtain under n the standard blood parameters concentration value each standard blood parameters concentration value m the pairing plug-in unit circuit output voltage of different temperature points value, obtain n*m test calibration point thus, (i j) represents the blood parameters concentration value with G, output voltage values U (i, j) expression, i=1 wherein, 2,3 ... n; J=1,2,3 ... m; At the laboratory timing signal, be by G (i, j) decision U (i, j), and when using the blood measuring instrument to detect be by U (i, j) decision G (i, j); U (i, j) and G (i, j) and the insertion algorithm procedure stores with digital processing system that the strip plug-in unit circuit of bleeding is connected in; When the strip plug-in unit circuit of bleeding measure output voltage values U and test calibration point U (i, j) just conform fashionable, then the blood parameters concentration value be exactly test calibration point G (i, j); When the strip plug-in unit circuit of bleeding is measured output voltage values U and test calibration point U (i, j) do not just conform fashionable, then adopt insertion algorithm, by two the test calibration point U (is adjacent with measuring output voltage values U, j) (i j) calculates blood parameters concentration value G to pairing two test calibration point G.
Described digital processing system is the branch body structure with the strip plug-in unit of bleeding, by both in conjunction with constituting the blood measuring instrument.
But described digital processing system comprises mobile phone, desktop computer, notebook computer or net book computer, originally intelligent or any visual equipment or equipment that operating system is arranged.
Described insertion algorithm adopts the straight line insertion algorithm.
Described insertion algorithm comprises from output voltage and temperature both direction and carries out interpolation calculation, promptly two-way insertion.
The calculation procedure of described two-way insertion is as follows:
(1) detection draws temperature t
0With voltage v
0, need be by v
0Obtain corresponding blood parameters concentration value g
0
(2) find out and t
0Immediate probe temperature T (y), and T (y-1), wherein T (y)＞t
0T (y-1)＜t
0
(3) find out when temperature T (y) and detection voltage v
0Immediate test voltage U (x, y) and U (x-1, y), wherein U (x, y)＞v
0U (x-1, y)＜v
0
(4) when temperature is T (y), voltage U (x, y) corresponding to blood parameters concentration value G (x, y); Voltage U (x-1, y) corresponding to blood parameters concentration value G (x-1, y);
(5) by G (x, y) and G (x-1 y), uses the straight line insertion, the blood parameters concentration value g when obtaining temperature T (y)
1
(6) find out when temperature T (y-1) and detection voltage v
0Immediate test voltage U (x, y-1) and U (x-1, y-1).Wherein U (x, y-1)＞v
0U (x-1, y-1)＜v
0
(7) when temperature is T (y-1), voltage U (x, y-1) corresponding to blood parameters concentration value G (x, y-1); Voltage U (x-1, y-1) corresponding to blood parameters concentration value G (x-1, y-1);
(8) by G (x, y-1) and G (x-1 y-1), uses the straight line insertion, the blood parameters concentration value g when obtaining temperature T (y-1)
2
G during (9) by temperature T (y)
1And the g during temperature T (y-1)
2, use the straight line insertion, obtain temperature t
0The time blood parameters concentration value g
0g
0Be to be check point blood parameters concentration value.
The described strip of bleeding comprises that blood glucose measurement strip, blood ketone are measured strip, blood fat measures strip or cholesterol is measured strip.
Described blood parameters concentration value comprises blood glucose value, blood acetone number, blood fat value or cholesterol value.
Technique effect is as follows:
The present invention utilizes insertion algorithm to improve the method for blood measuring accuracy, can be applied to the instrument of some content of material in the measurement blood of pin-point accuracy.It can reach pin-point accuracy, because we can use the error of software aspect to correct, make it error and reach minimum, so accuracy can reach the highest.Described method can be applied to glucometer, blood ketone measuring instrument, and the blood fat measuring instrument, the cholesterol measuring instrument, thus improve blood measuring accuracy.Described blood measuring adopts the strip (also claiming blood measuring strip or test paper) of bleeding, the strip of bleeding of standard has blood glucose measurement strip, blood ketone to measure strip, blood fat is measured strip, cholesterol measurement strip or the like, and strip obtains corresponding blood parameters concentration value with the digital processing system that is connected with its circuit by bleeding.
Description of drawings
Fig. 1 is the strip plug-in unit circuit structure principle schematic of bleeding.
Fig. 2 is that process flow diagram is demarcated in the laboratory.
Fig. 3 is the blood measuring process flow diagram that utilizes insertion algorithm.
Fig. 4 is at temperature and the two-way insertion synoptic diagram of voltage space.
Embodiment
The present invention is derived from the design of inventor to the portable glucose meter of pin-point accuracy.
One, design philosophy
Most important requirement is exactly accurate to people for Medical Instruments.Our design be the instrument of some content of material in the measurement blood of a pin-point accuracy.It can reach pin-point accuracy, because we can use the error of software aspect to correct, make it error and reach minimum, so accuracy can reach the highest.
It mainly comprises two parts, main frame and plug-in unit.Main frame is the device that " plug-in unit " inserts or be communicated with, and can be mobile phone, computing machine (comprise desk-top, notebook, net book etc.) and the instrument that display screen and operating system are similarly arranged, device.It is the main body of whole instrument.But concerning our present research and development, it is the object that has existed, and is not the product that we here research and develop.Our research and development product is " blood measuring plug-in module ", and in this paper, we abbreviate it as " plug-in unit ".
Though this research and development scope that main frame itself does not belong to us, the just object of selecting.But in order to cooperate with our plug-in unit, to need some specific softwares in the main frame and cooperate with our plug-in unit, we are called it " plug-in unit cooperation software ".Had " plug-in unit cooperation software ", main frame could cooperate with our plug-in unit, accepts the instruction of plug-in unit, shows the instruction of plug-in unit and shows measurement result.The two is combined as a whole, become one complete, comprise the surveying instrument of measurement, demonstration, storage, transmission.
" plug-in unit " is the main body that we research and develop and apply for a patent.It can do blood testing, detects the content of some material in the blood (for example blood sugar, blood fat, blood ketone, cholesterol or the like), then testing result digitizing input main frame.Its his measurement pattern is to insert strip, bleeds, and measures the result then, sends into main frame.Its measurement content mainly includes:
Measuring blood: plug-in unit is exactly the blood glucose measurement plug-in unit, or simply is called " blood glucose meter plug-in unit ".
Measure blood ketone: plug-in unit is exactly a blood ketone measure plug-in, or simply is called " blood ketone instrument plug-in unit ".
Measure blood fat: plug-in unit is exactly the blood fat measure plug-in, or simply is called " blood fat instrument plug-in unit ".
Measure cholesterol: plug-in unit is exactly the cholesterol measure plug-in, or simply is called " cholesterol plug-in unit ".
Also has other type or the like.Our designed plug-in unit is " slave " for main frame, and " master and slave " relation is arranged with main frame.Leave main frame, it can't show measurement result.On the other hand, because demonstration, calculating, storage and various other performances are the equipment that has utilized main frame all, so the used part of plug-in unit seldom, cheap, volume is very little, can make and the similar size of daily U-dish, is easy to carry very much.
For convenience of explanation, let us says something with blood glucose meter.In fact, for other instruments that detects blood, principle is also basic identical.In blood glucose meter, we at first will demarcate the relation curve that the blood sugar concentration drop on (or being put on) test paper and last blood glucose meter produce voltage in the laboratory.When detecting patient's blood sugar, just can calculate patient's blood sugar numerical value conversely then according to this curve by the voltage that blood glucose meter produces with blood glucose meter.
The structure of " plug-in unit " as shown in Figure 1.Fig. 1 is the strip plug-in unit circuit structure principle schematic of bleeding, and comprises strip interface 51, and this interface has 6 pin, is respectively the 1-power supply, and the 2-strip inserts signal, and the 3-strip inserts signal, 4-ground, 5-strip measuring-signal, 6-strip identification signal.Strip interface 51 connects blood testing module 60, and this module comprises mu balanced circuit 52, operational amplifier 53, and ADC 54, temperature compensation 55, other external circuits 56, microprocessor 57, this microprocessor have USB interface 58 and wireless transport module 59.The design of " plug-in unit " and principle of work are: droplet of blood is after inserting on the test paper of blood glucose meter, oxidase on the test paper and the blood sugar in the blood are had an effect, produce electronics, through the blood glucose meter collection and become voltage, find its pairing blood glucose value through amplifying again, through analog to digital conversion, become digital signal and can input to main frame.At main frame, with its in advance voltage accurately and the temperature correction curve of input, it is proofreaied and correct, promptly obtain corrected, blood sugar numerical value accurately.Just can show, store, or carry out other processing.
Two, error analysis
1. the source of error: with the blood glucose meter is that example says something.Improve accuracy and will reduce error as far as possible.The flow process that blood glucose meter is measured blood is, the blood sugar in the oxidase of the test paper contact blood and produce electric current at first, electric current becomes voltage, again through amplification, conversion, be blood sugar numerical value by voltage transitions more at last, be presented on the screen and preserve.To final voltage, become the blood sugar numerical value of demonstration by the blood sugar numerical transformation on the test paper again by final voltage transformation.At last the blood sugar numerical value of Xian Shiing must with test paper truly measure consistent.If inconsistent, there is error exactly.
The error of portable glucose meter is mainly derived from blood glucose meter itself and test paper two aspects.The error that whole blood glucose meter is measured is the stack of the two, and these two kinds of errors all need to reduce.Reduce the test paper error, key is to guarantee the consistance of same batch of every test paper, just requires the measuring blood function of same batch of test paper identical.This is the problem of the design and the manufacturing of test paper.This problem is solved by the design of test paper, and we wouldn't discuss in the present invention, waits until from now on solving.The present invention only discusses the error of blood glucose meter itself and reduces the method for these errors.The software and hardware problem of blood glucose meter design itself just only is discussed and is reduced their error problem.
So here, we think that same batch the performance of test paper is identical.Before a collection of test paper dispatched from the factory, we can under lab demarcate.
2. the principle of work of blood glucose meter: after test paper inserted the blood glucose meter testing jack, be known as G with concentration of glucose
1Test droplets on (or being put on) test paper, so the other end produces electric current, after the amplification calculation process through the blood glucose meter circuit, can output voltage U
1Because blood sugar G
1Produce voltage U 1 at experimental determination, conversely, we just can determine, when detecting for the patient, be U if measure output voltage
1, we can think that the blood sugar concentration that produces it promptly is G
1So, just can on screen, show G
1
In fact, different output voltages is just corresponding to different blood sugar numerical value.Here, a relation curve is arranged between output voltage and the tested blood sugar, promptly is voltage-blood sugar relation curve, and this curve reflects between output voltage and the tested blood glucose value and concerns, output voltage has been arranged, just can find pairing blood sugar numerical value from this voltage-blood sugar relation curve.
This voltage-blood glucose curve should be an empirical curve.Demarcate with the corresponding voltage of measuring and draw by testing blood sugar accurately in the laboratory.When using blood glucose meter, blood glucose meter converts blood sugar numerical value by the voltage that draws automatically to according to curve and shows then.If just on some test points, if the circuit of blood glucose meter does not cause other errors, this result should be accurately to the magnitude of voltage of measuring.
Is but the number of test point limited, how according to the data of these test points whole piece voltage-blood sugar relation curve that draws? the blood glucose meter deviser at present adopts a polynomial curve to approach this empirical curve.Generally getting 3 order polynomials approaches.Promptly get:
Y＝A
3X
3+A
2X
2+A
1X+A
0
A wherein
0, A
1, A
2, A
3, be given constant, by the experiment decision.To the test paper of different batches, different A is arranged
0, A
1, A
2, A
3, constant.But it is not accurate enough only replacing real empirical curve with the curve that 4 parameters are arranged, and has only 4 points can determine accurately.Other points cause error unavoidably.This is an important source of blood glucose meter error.
The another one source of error is a temperature error.Oxidase on the test paper can produce electric current after running into blood sugar, but the size of generation electric current is temperature-dependent.So, when the electric current that is produced by blood glucose meter is calculated blood sugar numerical value conversely, also to consider Temperature Influence.The method of at present general blood glucose meter is to establish a temperature correction facotor K, and K is generally between 0.7 to 1.3.When measuring blood, behind voltage derivation blood sugar numerical value, multiply by this temperature correction facotor again, be only the last blood sugar numerical value that goes out (also can multiply by COEFFICIENT K earlier, remove to look into pairing blood sugar numerical value again) measuring voltage.Under same temperature, different voltages are all adopted this same COEFFICIENT K, be a simple bearing calibration, cause error unavoidably.But concerning present blood glucose meter on the market, main error will correct by hardware circuit design, can accomplish this point, and this has been not easy.
3. raising method of accuracy:
To computing machine, smart mobile phone, or any instrument that operating system is arranged have powerful software function.Our blood glucose meter plug-in unit since will link to each other with the powerful instrument of these software functions, just can utilize their powerful software function to finish these corrections exactly.Use these software, we can make than above-mentioned cubic polynomial accurate the voltage-blood glucose curve of Duoing, thereby eliminated this most important error.Be that with the difference of blood glucose meter in the market we can utilize the powerful software and the calculation function of main frame, so can be the elimination of this voltage blood sugar transformed error.And blood glucose meter does not in the market have this function, so can't reduce this error energetically.
For our blood glucose meter plug-in unit, the hardware of computing machine or mobile phone need not made any change, just the software typing that designs is in advance got final product.She Ji software can be done very accurately and proofread and correct like this, makes accuracy be higher than all present portable glucose meters, thereby makes the portable glucose meter of pin-point accuracy.
The error of blood glucose meter itself also derives from the quality of used electron device.For example the precision of electronic original part itself is not enough and the problem of aging of part.Solution is to adopt high-precision electronic original part, for example high-precision resistance, electric capacity.As for problem of aging, can require at set intervals (for example three months) need carry out accuracy test.Or, can require to upgrade in time, or free old for new service because blood glucose meter plug-in unit cost is very low.
4. utilize software to reduce error:
By preceding surface analysis as can be known, the blood glucose meter output voltage, relevant with the relation and the blood sugar numerical value of blood sugar on the test paper with two factors of temperature.In order to understand the influence of these two factors to error, we at first will demarcate in the laboratory.
The process of demarcating is, gets a standard test paper and inserts blood glucose meter, and at a certain temperature, with the normal concentration blood sugar drips of solution of the blood sugar concentration G end at test paper, the test paper other end promptly produces electric current.Through conversion, after the amplification, produce voltage U at the blood glucose meter output terminal.We can measure the size of this voltage U.We say that this voltage U is just corresponding to the blood sugar concentration G on test paper under the given temperature conditions.In other words blood sugar G (i, j) output voltage U of corresponding blood glucose meter (i, j).That is to say, blood sugar concentration be G (i, blood sugar concentration j) drops on the test paper, the voltage of generation be U (i, j).(i is that (i j) produces blood sugar concentration G j) to this U conversely speaking.
After the blood glucose meter test paper splashes into patient's blood sugar, can measure the output voltage that blood glucose meter produces, after temperature was measured, according to above-mentioned calibration result, we just can instead release the blood glucose value that splashes into blood sugar.Let us is proceeded in two phases, and at first is described in the flow process that blood sugar and output voltage are demarcated in the laboratory, and then narration is how when detecting patient's blood sugar, and how blood glucose meter converts the detection voltage of measuring to the blood glucose value of detection blood sugar automatically.
We represent the different brackets of blood sugar with i, represent the different brackets of temperature with j.Just the blood glucose meter output voltage U (i, j). corresponding to blood glucose value G (i, j): i=1 wherein, 2 ... n; J=1,2 ... m.Be exactly that blood sugar is divided into n test point, temperature is divided into m test point.Certainly, n and m get any value, answer the requirement and the breadboard conditional decision of collimation exactness.For one thing, if get n=30, and m=5, so just to do 150 test points altogether.Get so many test points, deal with quite difficulty with present blood glucose meter on the market.But, address these problems on computing machine or mobile phone with software and to have no problem our intelligent blood glucose meter plug-in unit.Because the operating system of single-chip microcomputer is all very powerful on computing machine or the mobile phone, solves this condition judgment problem (just the most frequently used during computer programming " if-then problem ") with software and have no difficulty.
At the laboratory timing signal, be the intensity that determine to produce voltage by known blood sugar concentration, that is: G (i, j) → U (i, j);
Conversely, when detecting patient's blood sugar, be the concentration that detects blood sugar by the decision of the voltage on the blood glucose meter, that is: U (i, j) → G (i, j);
Certainly, when detecting blood sugar for the patient, if testing result just in time overlaps (promptly detecting the voltage and the just in time data coincidence of a certain test point of temperature that draw) with the data of a certain test point, problem is just very simple, and the blood sugar numerical value of this test point is exactly patient's testing result.If testing result does not just in time overlap with the data of a certain test point, we will use insertion in adjacent two test points.We use the straight line insertion.Obtain abundantly as long as count, the distance between adjacent 2 is enough near, insert with straight line between 2, and also be enough accurately.
Three, the flow process of demarcating in the laboratory:
Demarcate temperature and blood sugar concentration to the blood glucose meter output voltage influence in the laboratory, Fig. 2 is that process flow diagram is demarcated in the laboratory.As shown in Figure 2, method is as follows:
1. (102) are divided into n interval (each interval is not necessarily isometric) to the test range of blood sugar, promptly under a certain temperature conditions:
G=G (i), i=1 wherein, 2,3 ... n.
2. (103) are divided into m interval (each interval is not necessarily isometric) promptly with Range of measuring temp:
T=T (j), j=1 wherein, 2,3 ... m.
(104) so, the normal concentration blood sugar test liquid that prepare n kind variable concentrations is corresponding to a said n blood sugar interval, and demarcates in m different temperatures interval.So the function of output voltage U test blood sugar G (i) and temperature T (j), i.e. output voltage U=U (G (i), T (j)), or U=U (i, j)
Equally, we also can be the various criterion in when test under different temperatures test blood sugar, be written as G (i, j).So we say, when continuing test in the laboratory (demarcations) be exactly to find out U (i, j) and G (i, corresponding relation j), i=1 wherein, 2,3 ... n.; J=1,2,3 ... m.
(105) when the test blood sugar concentration of standard be G (i in the time of j), can measure the test voltage of generation on blood glucose meter, we it be defined as U (i, j), in other words U (i, j) corresponding to G (i, j).To i=1,2,3 ... n.; And j=1,2,3 ... m.
5. (106) to all i, j finishes above-mentioned steps, finish n*m test point after, just finish i, after whole demarcation of j, whole calibrating work is promptly all finished.
6. (107) at the laboratory timing signal, be by G (i, j) decision U (i, j), and when using blood glucose meter to detect be by the U that measures (i, j) decision blood sugar G (i, j).
When detecting blood sugar for the patient, if the test blood sugar be in the i point, temperature is in the j point, the voltage of measuring be exactly U (i, j).This moment, we just showed on screen that it is pairing, and the blood glucose value G that demarcation is good (i, j).
7. (108) if detecting voltage does not just in time overlap with some test points, but is between certain two test point, and said method just can not directly be used.Must insert with insertion.Specific practice is a joint as follows, the practical application when the application blood glucose meter goes to detect patient's blood sugar.
8. (109) owing to have blood sugar and two variablees of temperature, when (x, (x y) during conversion, does two-way interpolation possibly y) to arrive G by U.Specific practice is seen process flow diagram 3.
Four, use blood glucose meter and remove to detect patient's blood sugar (using " two-way insertion "):
In this article, we are with detected temperatures, detect voltage and detect blood sugar to be illustrated in temperature when detecting blood sugar for the patient, voltage, and blood glucose value.With probe temperature, test voltage and test blood sugar are illustrated in the temperature of laboratory timing signal, voltage, and blood glucose value.
All just in time overlap with some test points with temperature if detect voltage, problem is just fairly simple, and the blood glucose value of this test point is exactly our result.Do not overlap with the data of any one test point if detect voltage and detected temperatures, we will adopt " two-way insertion ", promptly all take insertion at voltage and temperature both direction.But to solve singly.Can solve the insertion of voltage earlier, and then solve the insertion of temperature.Fig. 3 is the blood measuring process flow diagram that utilizes insertion algorithm.As shown in Figure 3, specific practice is as follows:
1. establishing detected temperatures is t
0, detecting the blood glucose meter output voltage that draws is v
0, corresponding detection blood sugar (being patient's blood sugar of measuring) is g
0
2. find out and t
0Immediate two probe temperature T (y) and T (y-1), one greater than another less than t
0) (also can get y+1 and y).Be y constituent element and (y-1) the individual constituent element in the probe temperature series.。When temperature T (y), with test voltage v
0Immediate test voltage be U (x, y), promptly when temperature T (y), x constituent element in the test voltage.Another one and v
0Immediate test voltage be U (x-1, y), promptly when temperature T (y), x-1 constituent element in the test voltage.
3. as shown in Figure 4, should make earlier when temperature is T (y), with detection voltage v
0Immediate two test voltage U (x, y) and U (x-1, y), one greater than v
0, one less than v
0
Then by the U of test point (x, y) and U (x-1, y) make test point blood sugar concentration G (x, y) and G (x-1, y).
5. obtain test blood sugar concentration G with the straight line insertion, computing formula is:
6.g
1＝G(x-1，y)+(U-U(x-1，y))(G(x，y)-G(x-1，y))/(U(x，y)-U(x-1，y))
7. as shown in Figure 4, should make then when temperature is T (y-1), with detection voltage v
0Immediate two test voltage U (x, y-1) and U (x-1, y-1), one greater than v
0, one less than v
0
Then by the U of test point (x, y-1) and U (x-1, y-1) make test point blood sugar concentration G (x, y-1) and G (x-1, y-1).
9. obtain test blood sugar concentration G with the straight line insertion, computing formula is:
10.g
2＝G(x-1，y-1)+(U-U(x-1，y-1))(G(x，y-1)-G(x-1，y-1))/(U(x，y-1)-U(x-1，y-1))
11.g
1And g
2Be that temperature is that T (y) is corresponding blood sugar numerical value with T (y-1), so be t in temperature
0, the time blood glucose value should be at blood glucose value g
1And g
2Between draw with same insertion.
Fig. 4 is at temperature and the two-way insertion synoptic diagram of voltage space.As shown in Figure 4, can or anyly there be the equipment of operating system to realize of the two-way insertion of blood measuring data, to eliminate error by computing machine at temperature and voltage space.
Five. application example: the demarcation of a blood glucose meter and use
We say something with the application example of a blood glucose meter.
1. determine the relation between blood sugar and the voltage: detect needs according to diabetes, blood sugar concentration is a certain interval the most important (for example from 1.5-40.0mmol/L), we can get some test points on this section blood sugar, the spacing between per two test points is not necessarily identical.This is in these test points, and blood glucose value is respectively:
G1, G2 ... Gi ... Gn; Gi+1＞Gi wherein, i=1,2 ... n-1.
These blood sugar tests, making the last output voltage of blood glucose meter is U1, U2 ... Ui ... Un..Just these blood glucose values are U1 corresponding to the blood glucose meter output voltage, U2 ... Ui ... Un..So after so demarcating, if the blood glucose meter output voltage is Ui, the blood glucose value of his correspondence is exactly Gi, we say: Ui is corresponding to Gi; I=1 wherein, 2 ... n.
When if the voltage of blood glucose meter is output as Ui, the blood glucose value of measuring is exactly Gi; (i=1 wherein, 2 ... n).
2. if the blood sugar numerical value of Ce Lianging does not overlap with a certain test point Gi just, the voltage of blood glucose meter output just can not overlap the Ui coincidence with test point voltage yet so, so how handle? just must use the two-way insertion of joint narration goes to solve.
Should be pointed out that the above embodiment can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.Therefore, to not breaking away from the technical scheme and the improvement thereof of the present invention's spirit and technical spirit, all should be encompassed in the protection domain of patent of the present invention.For example, the blood sugar in the embodiment can be blood measuring parameters such as blood ketone, blood fat or cholesterol also, repeats no more.
Claims (8)
1. utilize insertion algorithm to improve the method for blood measuring accuracy, it is characterized in that, comprise the strip plug-in unit circuit chamber of experimentizing of bleeding is demarcated, obtain under n the standard blood parameters concentration value each standard blood parameters concentration value m the pairing plug-in unit circuit output voltage of different temperature points value, obtain n*m test calibration point thus, (i j) represents the blood parameters concentration value with G, output voltage values U (i, j) expression, i=1 wherein, 2,3 ... n; J=1,2,3 ... m; At the laboratory timing signal, be by G (i, j) decision U (i, j), and when using the blood measuring instrument to detect be by U (i, j) decision G (i, j); U (i, j) and G (i, j) and the insertion algorithm procedure stores with digital processing system that the strip plug-in unit circuit of bleeding is connected in; When the strip plug-in unit circuit of bleeding measure output voltage values U and test calibration point U (i, j) just conform fashionable, then the blood parameters concentration value be exactly test calibration point G (i, j); When the strip plug-in unit circuit of bleeding is measured output voltage values U and test calibration point U (i, j) do not just conform fashionable, then adopt insertion algorithm, by two the test calibration point U (is adjacent with measuring output voltage values U, j) (i j) calculates blood parameters concentration value G to pairing two test calibration point G.
2. the method for utilizing insertion algorithm to improve blood measuring accuracy according to claim 1 is characterized in that, described digital processing system is the branch body structure with the strip plug-in unit of bleeding, by both in conjunction with constituting the blood measuring instrument.
3. the method for utilizing insertion algorithm to improve blood measuring accuracy according to claim 1, it is characterized in that, but described digital processing system comprises mobile phone, desktop computer, notebook computer or net book computer, originally intelligent or any visual equipment or equipment that operating system is arranged.
4. the method for utilizing insertion algorithm to improve blood measuring accuracy according to claim 1 is characterized in that described insertion algorithm adopts the straight line insertion algorithm.
5. the method for utilizing insertion algorithm to improve blood measuring accuracy according to claim 1 is characterized in that, described insertion algorithm comprises from output voltage and temperature both direction and carries out interpolation calculation, promptly two-way insertion.
6. the method for utilizing insertion algorithm to improve blood measuring accuracy according to claim 1 is characterized in that the calculation procedure of described insertion algorithm is as follows:
(1) detection draws temperature t
0With voltage v
0, need be by v
0Obtain corresponding blood parameters concentration value g
0
(2) find out and t
0Immediate probe temperature T (y), and T (y-1), wherein T (y)＞t
0T (y-1)＜t
0
(3) find out when temperature T (y) and detection voltage v
0Immediate test voltage U (x, y) and U (x-1, y), wherein U (x, y)＞v
0U (x-1, y)＜v
0
(4) when temperature is T (y), voltage U (x, y) corresponding to blood parameters concentration value G (x, y); Voltage U (x-1, y) corresponding to blood parameters concentration value G (x-1, y);
(5) by G (x, y) and G (x-1 y), uses the straight line insertion, the blood parameters concentration value g when obtaining temperature T (y)
1
(6) find out when temperature T (y-1) and detection voltage v
0Immediate test voltage U (x, y-1) and U (x-1, y-1).Wherein U (x, y-1)＞v
0U (x-1, y-1)＜v
0
(7) when temperature is T (y-1), voltage U (x, y-1) corresponding to blood parameters concentration value G (x, y-1); Voltage U (x-1, y-1) corresponding to blood parameters concentration value G (x-1, y-1);
(8) by G (x, y-1) and G (x-1 y-1), uses the straight line insertion, the blood parameters concentration value g when obtaining temperature T (y-1)
2
G during (9) by temperature T (y)
1And the g during temperature T (y-1)
2, use the straight line insertion, obtain temperature t
0The time blood parameters concentration value g
0g
0Be to be check point blood parameters concentration value.
7. the method for utilizing insertion algorithm to improve blood measuring accuracy according to claim 1 is characterized in that, the described strip of bleeding comprises that blood glucose measurement strip, blood ketone are measured strip, blood fat measures strip or cholesterol is measured strip.
8. the method for utilizing insertion algorithm to improve blood measuring accuracy according to claim 1 is characterized in that described blood parameters concentration value comprises blood glucose value, blood acetone number, blood fat value or cholesterol value.
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| US4420564A (en) * | 1980-11-21 | 1983-12-13 | Fuji Electric Company, Ltd. | Blood sugar analyzer having fixed enzyme membrane sensor |
| EP0878713A2 (en) * | 1997-05-12 | 1998-11-18 | Bayer Corporation | Method and apparatus for correcting ambient temperature effect in biosensors |
| WO2007100651A1 (en) * | 2006-02-27 | 2007-09-07 | Bayer Healthcare Llc | Temperature-adjusted analyte determination for biosensor systems |
| CN101368922A (en) * | 2003-04-10 | 2009-02-18 | 宇东科技股份有限公司 | Method for judging blood sugar concentration |
| JP2009250806A (en) * | 2008-04-07 | 2009-10-29 | Panasonic Corp | Biosensor system, sensor chip and measuring method of concentration of analyte in blood sample |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4420564A (en) * | 1980-11-21 | 1983-12-13 | Fuji Electric Company, Ltd. | Blood sugar analyzer having fixed enzyme membrane sensor |
| EP0878713A2 (en) * | 1997-05-12 | 1998-11-18 | Bayer Corporation | Method and apparatus for correcting ambient temperature effect in biosensors |
| CN101368922A (en) * | 2003-04-10 | 2009-02-18 | 宇东科技股份有限公司 | Method for judging blood sugar concentration |
| WO2007100651A1 (en) * | 2006-02-27 | 2007-09-07 | Bayer Healthcare Llc | Temperature-adjusted analyte determination for biosensor systems |
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