CN101896226A - 将粒子束施加至病人 - Google Patents
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Abstract
一种设备包括具有第一端和第二端的轭。所述轭配置成保持包括孔径和范围补偿结构的装置。闩扣臂可枢转地固紧至轭第一端。所述闩扣臂包括锁定特征。所述锁定特征和所述轭的第二端分别连接通过孔径和范围补偿结构限定的第一保持特征和第二保持特征。所述锁定特征配置成交接至第一保持特征,所述轭第二端配置成交接至第二保持特征。
Description
技术领域
本申请涉及将粒子束施加至病人。
背景技术
为了治疗例如肿瘤,应当尽可能地将质子束施加至所有的肿瘤,但是尽可能不施加至周围的正常细胞组织。施束器可设置跨过病人附近的治疗束的两端,从而帮助控制质子束能够到达哪个细胞组织。
发明内容
这里描述的一种包括轭和闩扣臂的设备。该轭具有第一端和第二端,该轭配置成保持包括孔径和范围补偿结构的装置。闩扣臂可枢转地固紧至轭第一端。所述闩扣臂包括锁定特征。所述锁定特征和所述轭的第二端分别连接通过孔径和范围补偿结构限定的第一保持特征和第二保持特征。所述锁定特征配置成连接至第一保持特征,所述轭的第二端配置成连接至第二保持特征。该设备可单独地或组合地包括一个或多个下述特征。
所述轭可限定一凹槽,所述凹槽配置成容纳保持在所述装置上的凸缘。所述轭的第二端包括枢转特征,所述枢转特征包括圆整或匀称(rounded)凸起,所述第一保持特征可包括所述孔径和范围补偿结构其中的至少一个上的槽口。所述锁定特征可包括钩,所述第二保持特征可包括所述孔径和范围补偿结构其中的至少一个上的槽口。
该设备还可包括通过所述轭限定从而抑制所述闩扣臂的旋转的闩扣臂锁定特征。所述闩扣臂锁定特征可用于接合所述装置的闩扣臂锁。所述闩扣臂锁包括可定位成接合所述闩扣臂锁定特征的栓锁板。所述闩扣臂锁定特征配置成弹性偏置所述栓锁板。
该设备可包括指示器开关,用于检测所述闩扣臂的锁定和未锁定位置。至少一个弹性偏置柱塞可位于所述轭上并且可配置成促使所述装置抵靠所述锁定特征。
这里也描述一种将装置装载至装置支架上的方法。该方法包括定位由所述装置限定的第一保持特征从而由通过所述装置支架的轭限定的枢转特征容纳;移动所述装置跨过所述枢转特征并且进入所述支架;以及采用由枢转地固紧所述轭的闩扣臂限定的锁定特征固紧由所述装置限定的第二保持特征。该方法还可包括将由所述装置限定的凸缘对齐由所述轭限定的凹槽。
这里同样记载一种质子施束器支座,包括基部;多个辊,与所述基部相关联并且配置成支撑质子施束器;至少一个对齐块,所述对齐块与所述基部关联并且配置成容纳质子施束器的对应对齐柱;以及与所述基部相关联的锁定夹。所述锁定夹包括:夹持杆;连接至所述夹持杆的把手;由所述基部承载的可旋转轴;以及固紧至夹持杆和轴的第一和第二铰接件。每个铰接件包括:限定凸轮孔径和凸轮路径狭槽的铰接块;固紧至轴并且可旋转地承载在所述铰接块的凸轮孔径中的凸轮;所述基部上并且配置成由所述凸轮路径狭槽容纳的凸轮路径凸起。所述凸轮孔径和凸轮路径狭槽围绕所述轴导引所述铰接块的旋转和径向移动。所述质子施束器支座可单独地或组合地包括一个或多个下述特征。
所述凸轮限定限制特征,配置成由通过铰接块限定的对应凸轮孔径限制特征容纳从而限制所述凸轮的旋转。所述夹持杆包括至少对齐块,配置成容纳所述质子施束器的对应对齐柱。
该质子施束器支座可包括所述基部上的楔形榫头特征并且配置成对齐所述质子施束器。所述对齐块限定基本上V形形状的凹槽。所述对齐块限定基本上锥形的插座。所述把手包括栓锁,配置成由设置在所述基部上的栓锁接纳器容纳。所述第一和第二铰接件的每个凸轮是由弹簧偏置的。
这里同样描述一种用于质子施束器的运送车。该运送车包括:车体;设置在所述车体的上部上并且配置成支撑质子施束器的多个辊;至少一个对接联锁包括对接凸起,从所述车体向外延伸并且配置成通过设置在对接目标上的对接板容纳;对接凸轮枢转地连接至所述对接凸起并且配置成接合所述对接板从而抵靠所述对接目标保持所述车;以及至少一个施束器联锁包括锁定凸轮,其枢转地连接至车体的上部并且弹性偏置到锁定位置,所述锁定凸轮配置成保持质子施束器。
这里同样描述一种将质子施束器装载至辐射束发送系统的方法。该方法包括对接承载所述质子施束器的运送车抵靠所述辐射束输送系统。输送车的至少一个对接互联接合并且保持所述输送车抵靠所述辐射束输送系统。所述对接联锁包括:对接凸起,所述对接凸起向外从所述车主体延伸并且配置成通过设置在辐射束输送系统上的对接板容纳;以及对接凸轮,枢转地连接至所述对接凸起并且配置成接合所述对接板从而保持所述车抵靠所述辐射束输送系统。该方法也包括将支撑所述质子施束器并且设置在所述运送车上的多个车辊上的质子施束器移动至设置在辐射束输送系统的质子施束器支座上的多个支座辊。该方法可单独地或组合地包括一个或多个下述特征。
该方法可包括在移动所述质子施束器之前脱离设置在所述车上的施束器联锁。所述施束器联锁包括枢转地连接至所述车并且配置成保持所述质子施束器的锁定凸轮。该方法可包括在容纳所述质子施束器之后接合设置在所述质子施束器支座的基部上的锁定夹。所述锁定夹包括夹持杆;连接至所述夹持杆的把手;由所述基部承载的可旋转轴;以及固紧至夹持杆和轴的第一和第二铰接件。每个铰接件可包括限定凸轮孔径和凸轮路径狭槽的铰接块;固紧至轴并且可旋转地承载在所述铰接块的凸轮孔径中的凸轮;设置在所述基部上并且配置成由所述凸轮路径狭槽容纳的凸轮路径凸起。所述凸轮孔径和凸轮路径狭槽围绕所述轴导引所述铰接块的旋转和径向移动
本发明的这些和其他特征和方面以及它们的组合可以表述为方法、设备、系统和用于执行功能的装置以及其他方式。前述特征的任何特征可结合起来从而形成这里没有具体描述的实施例。
其他特征和优势将通过说明书和权利要求而清楚明了。
附图说明
图1至5是支架的透视图。
图6是病人孔径和范围补偿器组件的透视图。
图7是病人孔径的俯视图。
图8是病人孔径的侧视图。
图9是范围补偿器的侧视图。
图10是范围补偿器的俯视图。
图11是施束器和施束器安装系统的透视图。
图12是施束器安装系统的透视图。
图13是质子施束器的底部透视图。
图14-15是铰接件的侧视图。
图16是把手闩锁的侧视图。
图17-19是运送车的透视图。
图20-21是运送车对接连锁的侧视图。
图22-23是质子施束器连锁的侧视图。
具体实施方式
质子施束器系统(PAS)为病人体内的临诊目标诸如肿瘤提供质子束的最终对准和范围补偿。PAS也可屏蔽其他病人细胞组织防止应用于目标的辐射。
参照图1-3,支架100将作为质子施束器系统一部分的装置200(例如,病人孔径和范围补偿器)保持在装载位置。病人孔径可用于限制将质子束施加至病人细胞组织的程度。范围补偿器可用于为质子施束器提供相对于病人细胞组织的竖直补偿(例如,高度)。支架100包括分别具有第一端111和第二端112的主轭形件110,以及固定轭110上的枢转特征122(例如,凸起)。固定轭110可以是弧形的或者任何其他形状。枢转特征122可包括位于固定轭110的第一端111附近的圆形凸起。
装置200包括分别限定第一保持特征212和第二保持特征214的装置主体210。第一保持特征212和第二保持特征214可包括由装置主体210限定的槽口。枢转特征122可配置成容纳装置200的第一保持特征212。装置200在枢转特征122上枢转进入支架100。支架100包括枢转地连接至固定轭110的第二端112的锁定闩130以及容纳装置200的第二保持特征214的锁定特征134(例如,钩),由此将装置200保持在支架100中。锁定闩130可采用弹簧136而朝向锁定位置弹性偏置。装置200可通过相关联的边缘220而轴向地保持在支架100中,所述边缘由通过固定轭110限定的凹槽120容纳。保持特征212、214、枢转特征122和锁定特征134的形状和尺寸可适应装置200的外部大小。
参照图3,支架100包括指示器开关140,用于检测装置200是否存在以及锁定闩130的锁定或未锁定位置。当释放锁定闩130时,支架100上的弹性载荷柱塞145辅助装置200的弹出。弹性载荷柱塞145也保持装置200抵靠枢转特征122。锁定特征134布置成减小移动或者容忍晃动,这又使得装置200能够可重复地插入支架中。支架100可保持精确并且可重复进行数百个循环。
参照图4和5,支架100包括副锁定机构150。图4示出处于锁定位置的支架100,图5示出处于未锁定位置的支架100。在这一实例中,用户激活副释放按钮152并且稍微旋转锁定闩130从而从支架100释放装置200。连接至副释放按钮152和锁定闩130的栓锁板154采用压缩弹簧156而装载在锁定位置。该栓锁板154通过拐入由固定轭110限定的凹槽158而将锁定闩130锁定在载荷位置。当副释放按钮152和栓锁板154被向前拉动时,副释放连杆柱塞160移动进入由栓锁板154限定的卡销155中,由此将栓锁板154锁定在向前的位置,并且允许锁定闩130旋转。副释放连杆柱塞160通过弹簧162而朝向卡销155偏置。装置200可采用手动的方式安全地移除。
随着通过将装置200的第一保持特征212保持在枢转特征122上并且将装置200旋转进入支架100而将装置200插入支架100,锁定闩130枢转或者旋转进入装置200的第二保持特征214从而保持该装置200。随着装置200旋转进入支架100,副释放连杆柱塞160被致动向上进入锁定闩130,允许栓锁板154锁定进入由固定轭110限定的凹槽158。已锁定的栓锁板154减小了锁定闩130无意地向外旋转并且释放所述装置200的机会。
参照图6-10,多个支架100可层叠或叠置从而允许各种装置的厚度和重量范围。支架100能够锁定和保持的装置的实例包括病人孔径300和范围补偿器400。孔径300包括重复地限定第一保持特征312和第二保持特征314的孔径主体310。范围补偿器400包括重复地限定第一保持特征412和第二保持特征414的范围补偿器主体410。孔径300和范围补偿器400的每个通过第一保持特征312、412和第二保持特征314、414而保持在侧向和纵向方向。第一保持特征312和412配置成接合设置在支架100上的枢转特征122并且由该枢转特征接纳。第二保持特征314和414配置成由锁定闩130的锁定特征134接纳。装置300和400由支架100的相同特征122、134独立地装载并且保持。病人孔径300和范围补偿器400二者都分别包括保持边缘或凸缘320和420,配置成由固定轭110限定的凹槽120接纳以进行轴向保持。
参照图11-12,在这一实例中,质子施束器500包括施束器基部510和组件施束器520,其可固紧至基部510。如上所述的一个或多个支架可固紧至组件施束器520。在图11所示的实例中,四个支架100叠置并且固紧在组件施束器510上。该施束器安装系统600用于将质子施束器500安装至C-内部台架(C-Inner Gantry)(未示出)。该施束器安装系统600包括基部610、由基部610承载并且暴露在基部610的上表面612处的多个辊620,以及离心锁定夹(夹持杆)630。该锁定夹在运输期间将施束器保持定位。当锁定夹630降低时,施束器500可从施束器运送车700滚动至施束器安装系统600上(参见图18)。随着施束器500从车700传递至安装系统600,其通过基部610上的楔形榫头(dovetail)特征640而被保持住。楔形榫头特征640允许施束器500的路线对齐和轴向保持。在施束器500移动至其行程的末端时,其停留在固紧至基部610上的固定加工球对齐块650。
参照图12-13,对齐块650配置成与位于施束器基部510上的加工球柱550A(例如,加工球)相互连接。两种类型的加工球对齐块650安装在安装系统基部610上,V形凹槽对齐块650A限定V形槽,锥形对齐块650B限定锥形插座。V形槽对齐块650A轴向地限制施束器500,锥形对齐块650B将施束器500定位并且限制为垂直于载荷方向并且沿轴向方向。两个对齐块650A、650B用于将施束器500限制或定位在载荷方向。施束器基部510限定燕尾凹槽540,配置成与安装系统基部610上的燕尾特征640配合。施束器基部510限定辊凹槽512,其配置成容纳安装系统基部辊620。
离心锁定夹630定位在安装系统基部610与对齐块650相对的端部上。离心锁定夹630包括夹持杆632、设置在夹持杆632上的一对V形槽对齐块650A、连接至夹持杆632的锁定把手634,以及离心铰接件6000。锁定把手634(图16)包括副释放栓锁636,其包括副释放块636A,固紧至基部610并且配置成将副释放按钮636B保持在锁定把手634上。在受到致动时,离心锁定夹630将夹持力施加至施束器基部510上,将施束器500锁定至施束器安装系统600。该锁定夹630的离心铰接操作具有旋转分量,将夹持杆632带入位抵靠施束器基部510一侧上的弹簧加载加工球550B。锁定夹630的离心铰接操作也具有线性分量,向前驱动铰接杆632和V形槽对齐块650A来将施束器500锁定定位。
图14示出离心铰接件6000处于锁定位置。图15示出离心铰接件6000处于未锁定位置。离心铰接件6000包括铰接块6100,该铰接块6100固紧至夹持杆632并且设置在固紧至轴6210的铰接凸轮6200上。铰接块6100限定限制狭槽6110,该狭槽接纳凸轮凸起6212。限制狭槽6110定位成提供围绕中心的锁定操作从而锁定该夹630。在一些实例中,铰接块6100限定凸轮路径6112,该路径可保持固紧至安装系统基部610的定位销6300。凸轮路径6112控制铰接块6100的旋转行程限制。轴6210共用于两个离心凸轮6200。凸轮路径6112的形状允许离心凸轮6200进行线性运动。离心凸轮6200的旋转产生线性力分量,精确地并且可重复地将质子施束器500夹持定位。使用离心凸轮6200能够带来优于传统非离心夹的强大机械力。离心铰接件6000包括延伸弹簧6400从而控制离心凸轮6200的接合的时间。弹性力被平衡,使得随着夹持杆632旋转进入锁定位置,能够阻止离心凸轮6200的线性移动的致动。
参照图16,当铰接块6100和夹持杆632处于行程的旋转极限时,离心凸轮6200的线性分量接合并且锁定质子施束器500定位。为了脱离该夹630,可逆向地执行相同的操作。向前和逆向的移动可通过锁定把手634的旋转而得以控制。锁定把手634在副释放栓锁636的辅助下锁定定位,该栓锁是压缩弹簧加载的。将副释放栓锁636接合入副保持块637可栓锁该锁定把手634。
参照图17-19,施束器输送车700可用于传送和改变质子施束器600到C形内部台架(CIG)以及离开C形内部台架。该施束器运送车700包括具有上部702的支撑体710,质子施束器500位于其上。在一个实例中,两个不同尺寸的质子施束器500可设置有辐射束输送系统:大场质子施束器500(25厘米处理场直径)以及小场质子施束器500(14厘米处理场直径)。两个质子施束器500具有明显的重量和尺寸并且必须通过辐射治疗师而安全地运送和改变。改变质子施束器500应当以及时的方式完成从而增加每天治疗病人的数量。每个质子施束器500可具有运送车700,接入CIG一侧。
参照图20-21,对接联锁720防止运送车700在对接的同时向后离开C形内部台架。对接联锁720侧向且竖直地将运送车700对齐锥形突出舌722,该锥形突出舌对接入相关的具有狭槽的对接板822。对接板822位于CIG上。对接联锁720采用弹性载荷斜坡凸轮724而锁定入CIG,该凸轮通过保持表面726而卡入对接板822的相对侧。运送车700包括多个辊730,设置在运送车700的上部702上。辊730定位成支撑质子施束器500。
参照图22-23运送车700包括施束器联锁740,将质子施束器500保持在运送车700上。在一些实施方式中,施束器联锁740包括设置在运送车700的上部702上的至少一个斜坡弹性载荷锁定凸轮742。运送车700上的施束器释放把手744配置成接合和脱离(各)凸轮740。随着质子施束器500被推动至车700上,质子施束器500在凸轮742上移动,将其向下推入上部702,直到质子施束器500到达行程的末端。在行程的末端,斜面凸轮742暴露并且自由地向上弹起至弹性偏置位置,通过斜面凸轮742上的保持表面746而将质子施束器500保持定位。施束器联锁740类似于对接联锁720,通过利用类似类型的斜面凸轮装置将装置锁定定位。
为了运送施束器500离开传送车700以及到达施束器安装系统600上,施束器安装系统600的离心锁定夹630脱离至未锁定位置。运送车700上的施束器释放把手744脱离,治疗师推动质子施束器500离开运送车700并且到达施束器安装系统600上。质子施束器500在辊上行进从运送车700至施束器安装系统600的辊620。施束器安装系统600的锁定夹630接合入其锁定位置。对接联锁720脱离(例如,通过相关联的把手)并且运送车700从CIG释放并且移动离开至存储区域。移除质子施束器500需要如上所述的类似步骤。但是,当质子施束器500从CIG移动至运送车700时,用户不需要致动运送车700上的施束器释放把手742。
权利要求并不局限于上述实施方式。不同实施方式的元件可结合从而形成这里没有具体说明的其他实施方式。
其他实施方式也处于随后的权利要求的范围内。
Claims (22)
1.一种设备,包括:
具有第一端和第二端的轭,所述轭配置成保持包括孔径和范围补偿结构的装置;以及
可枢转地固紧至轭的第一端的闩扣臂(catch arm),所述闩扣臂包括锁定特征,所述锁定特征和所述轭的第二端分别连接由孔径和范围补偿结构限定的第一保持特征和第二保持特征,所述锁定特征配置成对接至第一保持特征,所述轭的第二端配置成对接至第二保持特征。
2.根据权利要求1所述的设备,其中,所述轭限定一凹槽,所述凹槽配置成容纳所述装置上包含的边缘。
3.根据权利要求1所述的设备,其中,所述轭的第二端包括枢转特征,所述枢转特征包括匀称(rounded)凸起,所述第一保持特征包括所述孔径和范围补偿结构其中的至少一个上的槽口。
4.根据权利要求1所述的设备,其中,所述锁定特征包括钩,所述第二保持特征包括所述孔径和范围补偿结构其中的至少一个上的槽口。
5.根据权利要求1所述的设备,还包括由所述轭限定从而抑制所述闩扣臂的旋转的闩扣臂锁定特征,所述闩扣臂锁定特征用于接合所述装置的闩扣臂锁,所述闩扣臂锁包括可定位成接合所述闩扣臂锁定特征的栓锁板。
6.根据权利要求5所述的设备,其中,所述闩扣臂锁定特征配置成弹性偏置所述栓锁板。
7.根据权利要求1所述的设备,还包括指示器开关,用于检测所述闩扣臂的锁定和未锁定位置。
8.根据权利要求1所述的设备,还包括所述轭上的至少一个弹性偏置柱塞并且配置成促使所述装置抵靠所述锁定特征。
9.一种将装置装载至装置支架上的方法,该方法包括:
定位由所述装置限定的第一保持特征从而由通过所述装置支架的轭限定的枢转特征容纳;
移动所述装置跨过所述枢转特征并且进入所述支架;以及
采用由枢转地固紧所述轭的闩扣臂限定的锁定特征固紧由所述装置限定的第二保持特征。
10.根据权利要求9所述的方法,还包括将由所述装置限定的边缘对齐由所述轭限定的凹槽。
11.一种质子施束器支座,包括:
基部;
多个辊,与所述基部相关联并且配置成支撑质子施束器;
至少一个对齐块,所述对齐块与所述基部关联并且配置成容纳质子施束器的对应对齐柱;以及
与所述基部相关联的锁定夹,所述锁定夹包括:
夹持杆;
连接至所述夹持杆的把手;
由所述基部承载的可旋转轴;以及
固紧至夹持杆和轴的第一和第二铰接件,每个铰接件包括:
限定凸轮孔径和凸轮路径狭槽的铰接块;
固紧至轴并且可旋转地承载在所述铰接块的凸轮孔径中的凸轮;
所述基部上并且配置成由所述凸轮路径狭槽容纳的凸轮路径凸起,所述凸轮孔径和凸轮路径狭槽围绕所述轴导引所述铰接块的旋转和径向移动。
12.根据权利要求11所述的质子施束器支座,其中,所述凸轮限定一限制特征,其配置成由通过铰接块限定从而限制所述凸轮的旋转的对应凸轮孔径限制特征容纳。
13.根据权利要求11所述的质子施束器支座,其中,所述夹持杆包括至少一个对齐块,配置成容纳所述质子施束器的对应对齐柱。
14.根据权利要求11所述的质子施束器支座,还包括所述基部上的楔形榫头(dovetail)特征,所述楔形榫头特征配置成对齐所述质子施束器。
15.根据权利要求11所述的质子施束器支座,其中,所述对齐块限定基本上V形形状的凹槽。
16.根据权利要求11所述的质子施束器支座,其中,所述对齐块限定基本上锥形的插座。
17.根据权利要求11所述的质子施束器支座,其中,所述把手包括栓锁,配置成由设置在所述基部上的栓锁容纳器容纳。
18.根据权利要求11所述的质子施束器支座,其中,所述第一和第二铰接件的每个凸轮是由弹性偏置的。
19.一种用于质子施束器的运送车,包括:
车体;
设置在所述车体的上部上并且配置成支撑质子施束器的多个辊;
至少一个对接联锁,包括对接凸起,所述对接凸起从所述车体向外延伸并且配置成由设置在对接目标上的对接板容纳;
对接凸轮,枢转地连接至所述对接凸起并且配置成接合所述对接板从而保持所述车抵靠所述对接目标;以及
至少一个施束器联锁,包括锁定凸轮,其枢转地连接至车体的上部并且弹性偏置到锁定位置,所述锁定凸轮配置成保持质子施束器。
20.一种将质子施束器装载至辐射束发送系统的方法,该方法包括:
对接承载所述质子施束器的运送车抵靠所述辐射束输送系统,输送车的至少一个对接联锁并且保持所述输送车抵靠所述辐射束输送系统,所述对接联锁包括:
对接凸起,所述对接凸起向外从所述车主体延伸并且配置成通过设置在辐射束输送系统上的对接板容纳;以及
对接凸轮,枢转地连接至所述对接凸起并且配置成接合所述对接板从而保持所述车抵靠所述辐射束输送系统;以及
将支撑所述质子施束器并且设置在所述运送车上的多个车辊上的质子施束器移动至设置在辐射束输送系统的质子施束器支座上的多个支座辊。
21.根据权利要求20所述的方法,还包括在移动所述质子施束器之前脱离设置在所述车上的施束器联锁,所述施束器联锁包括枢转地连接至所述车并且配置成保持所述质子施束器的锁定凸轮。
22.根据权利要求21所述的方法,还包括在容纳所述质子施束器之后接合设置在所述质子施束器支座的基部上的锁定夹,所述锁定夹包括:
夹持杆;
连接至所述夹持杆的把手;
由所述基部承载的可旋转轴;以及
固紧至夹持杆和轴的第一和第二铰接件,每个铰接件包括:
限定凸轮孔径和凸轮路径狭槽的铰接块;
固紧至轴并且可旋转地承载在对应铰接块的凸轮孔径中的凸轮;
设置在所述基部上并且配置成由所述凸轮路径狭槽容纳的凸轮路径凸起,所述凸轮孔径和所述凸轮路径狭槽围绕所述轴导引所述铰接块的旋转和径向移动。
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Cited By (4)
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CN114110493A (zh) * | 2014-05-23 | 2022-03-01 | 豪倍公司 | 灯具 |
WO2018223487A1 (zh) * | 2017-06-05 | 2018-12-13 | 南京中硼联康医疗科技有限公司 | 用于中子捕获治疗的射束整形体 |
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CN107693956A (zh) * | 2017-10-31 | 2018-02-16 | 重庆京渝激光技术有限公司 | 方便定位的激光治疗机 |
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TW200934682A (en) | 2009-08-16 |
US20090096179A1 (en) | 2009-04-16 |
EP2219732A2 (en) | 2010-08-25 |
US8941083B2 (en) | 2015-01-27 |
JP5336499B2 (ja) | 2013-11-06 |
US20110299919A1 (en) | 2011-12-08 |
JP2011500152A (ja) | 2011-01-06 |
ES2452930T3 (es) | 2014-04-03 |
WO2009048745A2 (en) | 2009-04-16 |
WO2009048745A3 (en) | 2009-11-19 |
US8003964B2 (en) | 2011-08-23 |
CA2702036A1 (en) | 2009-04-16 |
TWI401176B (zh) | 2013-07-11 |
EP2219732B1 (en) | 2013-12-18 |
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