CN101563042A - 自动对准的消融装置及其使用方法 - Google Patents

自动对准的消融装置及其使用方法 Download PDF

Info

Publication number
CN101563042A
CN101563042A CNA2006800522005A CN200680052200A CN101563042A CN 101563042 A CN101563042 A CN 101563042A CN A2006800522005 A CNA2006800522005 A CN A2006800522005A CN 200680052200 A CN200680052200 A CN 200680052200A CN 101563042 A CN101563042 A CN 101563042A
Authority
CN
China
Prior art keywords
ablation
longitudinal carrier
ablation structure
runing rest
ablating device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA2006800522005A
Other languages
English (en)
Other versions
CN101563042B (zh
Inventor
M·P·华莱士
R·加拉贝迪安
B·格伯丁
W·丘恩格
D·S·厄特利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Balkis Medicine LLC
VNUS Medical Technologies LLC
Covidien LP
Original Assignee
BarRx Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BarRx Medical Inc filed Critical BarRx Medical Inc
Publication of CN101563042A publication Critical patent/CN101563042A/zh
Application granted granted Critical
Publication of CN101563042B publication Critical patent/CN101563042B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery
    • A61B34/71—Manipulators operated by drive cable mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/00296—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means mounted on an endoscope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00273—Anchoring means for temporary attachment of a device to tissue
    • A61B2018/00279—Anchoring means for temporary attachment of a device to tissue deployable
    • A61B2018/00285—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/00488—Esophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B2018/044—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid
    • A61B2018/046—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid in liquid form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1495—Electrodes being detachable from a support structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50—Supports for surgical instruments, e.g. articulated arms

Abstract

本发明涉及一种消融装置及其使用方法，所述消融装置包括能够在患者消化道内支承消融结构的支架结构。所述支架结构包括旋转支架和具有纵向轴线的纵向支架。所述旋转支架能够允许消融结构的至少一部分相对于纵向支架的纵向轴线旋转。

Description

自动对准的消融装置及其使用方法
技术领域
本发明涉及一种用于消融消化道中的组织的医疗装置及其使用方法。
背景技术
人类食管的主要功能是将固态和液态营养物质从口腔输送到胃中。食管具有与生俱来的协调的收缩能力，使得物质沿着顺行方向(向着胃)蠕动。此外，食管分泌中性pH值的粘液来润滑食物通道以及保护食管内层不受由酸引起的损伤。胃包含经口腔摄入的食物和液体、来自胃内层的酸和酶、来自肝和胰腺的胆汁和酶组成的混合物。下食管括约肌和膈肌用作食管和胃的接头处的瓣，防止胃内容物反流进入食管。所述下食管括约肌通常保持闭合直至副交感神经活动或食团的到来使其松弛，以便允许食物从食管进入胃中。胃扩张尤其是胃的贲门部分扩张使下食管括约肌突然放松，导致排气现象(打嗝)。含有咖啡因或茶碱(黄嘌呤)的某些食物、药品和饮料容易导致下食管括约肌不当地松弛，并继而发生反流。与衰老或食管裂孔疝有关的解剖效应也容易导致患者产生反流。
下食管括约肌功能异常的患者可能表现出吞咽不利(吞咽困难)、反流引起的胃灼热、胸痛症状以及其它有关症状。慢性胃食管反流的常见病症是糜烂性食管炎。当长期暴露在有害的胃内容物下，食管内层可能受损，形成炎症、糜烂或溃疡。慢性胃食管返流病(GERD)和产生的糜烂性食管炎可以导致被称为巴雷特食管或肠上皮化生的癌变前期病状，巴雷特食管或肠上皮化生是上皮细胞中的与损伤有关的基因变化。
例如在2004年1月9日提交的序列号为No.10/754445的共同未决且共同所有的美国专利申请中所述，具有可扩张电极支架的治疗导管可用于治疗食管的环状区域，以便利用射频(RF)能量消融食管的异常粘膜层。如果成功，该治疗法使正常粘膜层再生，而基本上没有以巴雷特食管为特征的受到化生和其它损伤的上皮细胞。
但是，在一些情况下，这种射频消融治疗不可能完全成功并且可能留下一块或更多的异常粘膜区域。这些病灶区域可以使用设有更适合消融粘膜疾病病灶区域的表面区域的装置来处理。另外，一些巴雷特食管患者可能最初出现很有限的疾病区域，为非环形片段或非常短的片段，这可能更适合病灶消融而不是环形消融。
发明内容
在一个方面中，本发明总体上涉及消融装置及其使用方法，所述消融装置包括消融结构和能够将消融结构支承在患者消化道内的支架结构。在一种实施方式中，所述消融装置的支架结构包括旋转支架和具有纵向轴线的纵向支架。所述旋转支架能够允许消融结构的至少一部分相对于纵向支架的纵向轴线运动。
本发明的实施方式包括一个或多个以下特征。旋转支架可以适合以至少一个自由度旋转。在一种替代实施方式中，旋转支架可以适合于以至少两个自由度旋转。在另一种替代实施方式中，旋转支架可以适合于以至少三个自由度旋转。
旋转支架可以包括能够限制转动范围的止动构件。旋转支架可以包括运动阻件(move resistor)。在一种实施方式中，所述运动阻件包括弹簧。在另一种实施方式中，旋转支架包括适于防止消融结构转动的锁止件。
在一种实施方式中，消融装置包括适于防止消融结构转动的致动机构。
支架结构可以包括内窥镜。作为替代方式，支架结构可包括导管。
消融结构可以包括至少一个电极。在一种实施方式中，可以通过支架结构支承多个消融结构。在另一种实施方式中，消融结构能够对组织进行低温消融。
在另一方面中，本发明总体涉及在消化道中消融组织的方法，所述方法包括以下步骤：将消融结构推进到消化道内；用支架结构将消融结构支承在消化道内；将消融结构的至少一部分从支架结构转动离开并向着组织表面旋转；以及激活消融结构，以便对组织表面进行消融。
本发明的实施方式包括消融组织的方法，其中旋转步骤包括在消融结构和组织表面之间施加力。在另一种实施方式中，推进消融结构的步骤包括推进多个消融结构，旋转步骤包括通过在多个消融结构中的一个或多个与组织表面之间施加力来旋转多个消融结构中的一个或多个的至少一部分。
旋转步骤可以包括围绕至少一条旋转轴线旋转消融结构的至少一部分。在一种实施方式中，旋转步骤包括围绕至少两条旋转轴线旋转消融结构的至少一部分。在另一种实施方式中，旋转步骤包括围绕至少三条旋转轴线旋转消融结构的至少一部分。
在一种实施方式中，消融组织的方法还包括限制消融结构的转动范围。在另一种实施方式中，所述方法还包括在旋转消融结构的同时阻止消融结构的旋转。在一种附加实施方式中，所述方法还包括锁定消融结构以防止消融结构旋转。
推进消融结构的步骤可以包括将内窥镜推进到消化道内。在一种实施方式中，支承步骤包括用内窥镜支承消融结构。
在一种实施方式中，消融结构包括至少一个电极，并且激活步骤包括给电极提供电能。在另一种实施方式中，消融结构具有低温消融的能力，并且激活步骤包括将过冷流体供应到消融结构。
附图说明
本发明的新颖性特征特别是在附带的权利要求书中提出。通过参照以下给出了示例性实施方式的详细描述和附图可以更好地理解本发明的特征和优点，在这些实施方式中使用了本发明的原理，其中：
图1是包括示出了运动自由度的坐标轴的本发明的消融装置的视图。
图2A是包括旋转支架和示出了运动自由度的坐标轴的支架结构的剖视图。
图2B是包括另一种旋转支架和示出了运动自由度的坐标轴的支架结构的剖视图。
图2C是包括又一种旋转支架和示出了运动自由度的坐标轴的又一种支架结构的视图。
图2D是包括另一种旋转支架的另一种支架结构的视图。
图2E是包括又一种旋转支架和示出了运动自由度的坐标轴的又一种支架结构的视图。
图3A是本发明的消融装置的视图。
图3B是另一种旋转支架的视图。
图3C是另一种替代的旋转支架的视图。
图4A是在消化道环境中与内窥镜结合的本发明消融装置的视图。
图4B是本发明消融装置的视图，所述消融装置包括与内窥镜结合的唇片特征部和电极挽绳(electrode trace)。
图4C是本发明消融装置的视图，所述消融装置包括与内窥镜结合的唇片特征部、端口和管线。
图5是本发明的消融装置与内窥镜结合的视图，所述消融装置包括支架结构和两个消融结构，所述支架结构具有两个旋转支架和两个纵向支架。
图6是本发明的包括运动阻件的消融装置的视图。
图7A和7B是本发明的包括另一种运动阻件的消融装置的视图。
图8A和8B是本发明的包括又一种运动阻件的消融装置的视图。
图9A和9B是本发明的包括另一种运动阻件的消融装置的视图。
图10是本发明的包括另一种运动阻件的消融装置的视图。
图11A、11B和11C是本发明的包括一种替代的运动阻件的消融装置的视图。
图12是本发明的包括致动机构的消融装置的视图。
图13是本发明的连接到内窥镜上的消融装置的视图。
图14A和14B是消融装置的替代实施方式的视图。
图14C是如图14A和14B所示的消融装置的端视图。
具体实施方式
本发明提供了一种装置和方法，其使用包括支架结构的消融装置在患者或受检对象的消化道内消融组织，所述支架结构能够在消化道内支承消融结构。消融装置的支架结构包括旋转支架和具有纵向轴线的纵向支架。旋转支架适合允许至少一部分消融结构相对于纵向支架的纵向轴线旋转。根据本发明，消融装置被推进到消化道中。可选的是，消融装置可以支承在内窥镜的远端上。消融结构可以向着组织表面旋转地偏转，并且可以激活消融结构以消融组织表面。在消化道内，可以使用本文所述器械和方法有选择地消融各种尺寸的组织表面部位。
就本发明公开的目的而言，由粘膜和肌肉组成的、在口腔和肛门之间延伸的、起消化和排泻功能的任何部分都被认为是消化道的一部分。这些部分包括但不限于食管、胃、小肠、阑尾、大肠、结肠、直肠和肛管。
如图1所示，本发明的消融装置100总体上包括能够支承消融结构130的支架结构111。旋转支架116上支撑有带有纵向轴线并且支承消融结构130的纵向支架114。旋转支架116能够允许至少一部分纵向支架114相对于其纵向轴线旋转，以便允许至少一部分消融结构130旋转。旋转支架允许纵向支架114转动，所述转动包括但不限于例如旋转、枢转、翻转或回转。可以想到的是，纵向支架114可以从支架114的纵向轴线旋转开、或向着所述纵向轴线或绕所述纵向轴线旋转。
图1还以x、y和z坐标轴显示出纵向支架114，旋转支架116可以允许纵向支架114以多个可能的自由度运动。虽然在图1和后续图中只用单向箭头示出了围绕每条轴线的可能旋转，但是旨在表示围绕给定轴线的双向旋转。
如图1和2A所示，可将旋转支架116构造和布置成使得纵向支架114能够以三个自由度自由旋转。所述三个自由度标示在三条轴线x、y和z上。在附图中标有“是”的轴线表示能够围绕该轴线双向自由运动，而标有“否”的轴线表示不能围绕该轴线自由运动。可以想到的是，旋转支架可以适合以至少一个自由度、至少两个自由度、或至少三个自由度旋转。还可以想到的是，可以将消融装置构造和布置成为纵向支架提供沿着x、y或z平面(没有显示)的线性运动或浮动。例如，海绵或顺应性纵向支架可以允许沿着y方向的线性压缩(没有显示)。
如图2B至2E所示，可以将旋转支架116构造和布置成使得纵向支架114能够以两个自由度自由旋转。在图2B和2D的实施方式中，纵向支架能围绕x和y轴自由旋转但是不能围绕z轴自由旋转(见图2B所示的坐标轴和图2D所示的x和y轴)。在图2C和2E所示的实施方式中，纵向支架能够围绕x和z轴但是不能围绕y轴自由旋转。
如图5所示，支架结构111可以包括联接到两个纵向支架114上的单个旋转支架116，每个纵向支架114支承一个消融结构130。纵向支架114和底座112可以由顺应性材料(包括但不限于硅酮或聚氨酯)制成。可以想到的是，消融装置100可替代地包括联接到一个或多个旋转支架116上的两个或多个纵向支架114。
如图1、2A、2B、2D、2E、3A至3C、4A、4B、5、6、7A、7B、8A、8B、9A、9B、10、11A至11C、12和14A至14C所示，旋转支架还可以包括底座112部分。如下详细描述的，通常将底座112构造和布置成用于将消融装置100固定或连接到细长构件上的部件，所述细长构件包括但不限于例如内窥镜或导管。
可以将旋转支架116的一部分构造和布置成包括用于将旋转支架116连接到纵向支架114上并且为纵向支架114提供旋转运动的多种形状和结构中的任何形状和结构。可能的形状包括但不限于例如圆形、球形、等直径圆柱形、变直径圆柱形和椭圆球形。可能的结构包括但不限于例如一个或多个铰链、弹簧、万向接头、球形接头或关节接头。
如图1、2A、4B和5所示，在一种实施方式中，旋转支架116可以包括能够插入纵向支架114的凹槽或接收件例如插座中的球形部分。在另一种实施方式中，如图2B所示，旋转支架116可以包括具有凸起117特征的球形部分。在该实施方式中，凸起117与纵向支架114的槽115特征接合，由此允许纵向支架14沿着两条轴线x和y轴旋转，但不允许沿着z轴旋转。凸起117与纵向支架的槽115的接合防止了纵向支架114围绕z轴的旋转。
如图2C所示，在另一种实施方式中，旋转支架116可以包括细长球形或橄榄球形部分。如图中坐标轴所示，图2C中所示的实施方式被构造和布置成允许纵向支架114(没有显示)相对于两条轴线旋转。如所示，纵向支架114(没有显示)可以沿着x和z轴旋转但不能沿着y轴旋转。
如图2D所示，在另一种实施方式中，支架结构111可以包括具有销119和旋转支架116的万向接头。如所示，该实施方式允许纵向支架114(没有显示)围绕x和y轴旋转。可以想到的是，支架结构111可以包括两个或更多个万向接头。如图2E所示，在另一种实施方式中，旋转支架116可以包括弹簧。如所示出的坐标轴标示的，该实施方式允许纵向支架114围绕x和z轴旋转但是不能围绕y轴旋转。
如图3A至3C和14A至14C所示，在另一种实施方式中，支架结构111可以包括具有销119的结构。可以想到的是，销119可以穿过支架结构111的纵向支架114的一部分、旋转支架116、并且在一些情形中穿过底座112(或底座112的连接元件120)，由此连接纵向支架114和旋转支架116。通过纵向支架114围绕销119的旋转提供纵向支架114的至少一部分相对于其纵向轴线的旋转。可以想到的是，一个或多个万向接头可以与一个或多个销119结合使用，以便为纵向支架(没有显示)提供旋转运动。
如图14A和14B所示，其中支架结构111包括销119，纵向支架114围绕销119的旋转可以包括纵向支架114从零点位置(见图14A)到成角度或倾斜位置(见图14B)的运动范围。零点位置和倾斜位置对于组织表面的处理都很有用。包括薄轮廓的零点位置对于引入消融装置100和/或从处理部位移除消融装置100特别有用。
如图3B所示，在另一种实施方式中，旋转支架116除了包括销119之外还包括联接到销119上的弹簧124(例如扭簧)。如图3C所示，在又一种实施方式中，旋转支架116除了包括销119还包括联接到销119上的运动阻件123。在该实施方式中，运动阻件123可以由任何抵抗性(resistive)或顺应性物质或结构制成，所述物质或结构能够在销119偏转或旋转一段时间之后将销回复到期望的位置。适当的结构包括但不限于套筒或衬套，例如硅酮套筒或衬套。用于包覆或粘接销的适当材料包括但不限于硅酮、氨基甲酸乙脂或其它聚合物材料。其它适当的材料和结构为本领域技术人员所熟知。
可以想到的是，支架结构可以包括本文所述的旋转支架116特征的任何组合。
旋转支架的底座可以被构造和布置成以各种方式支承消融装置。在一些实施方式中，底座被构造和布置成将消融装置的支架结构连接到另一装置例如传统的胃窥镜上。例如，底座可以被构造和布置成将消融装置连接到内窥镜的外表面上。替代方式是，底座可以被构造和布置成将消融装置连接到内窥镜的内表面、外部或内部特征元件或以上的任何组合上。在一些实施方式中，如图1、3B至3C、4A和4B、6、7A和7B、8A和8B、9A和9B、10、11A和11B以及12所示，底座112被构造和布置成护套。在一种特别实施方式中，底座112包括弹性护套。在其它实施方式中，如图3A和14A至14C所示，底座112包括连接元件120以及箍或带126。在一种实施方式中，带126为弹性带。连接元件120可以在底座112和纵向支架114之间提供连接点。带126可以连接到连接元件120上并且用于例如连接内窥镜。如果需要，连接元件120和带126可以由相同或不同材料制成。如图14A至14C所示，连接元件120可以包括与纵向支架114成一定角度的斜的或倾斜部分。如图所示，在一种实施方式中，连接元件120的倾斜部分被设置在底座112的连接元件120上的销119对面。连接元件120的倾斜部分可以起到能够使消融装置100更容易取出的功能。
如图4B和4C所示，在一种实施方式中，旋转支架的底座112包括挡块或唇片113特征。唇片113可以被构造和布置成起挡块的作用，用于协助相对于辅助装置(例如所示的内窥镜127)对消融装置100进行定位。在如图4B至4C所示的示例中，可以通过唇片113来限制内窥镜127在旋转支架116的底座112内的定位。唇片113可以相对于内窥镜远端128指引或限制消融装置100的远侧/近侧位置。
通常，在一方面，消融装置100包括如图6、7A和7B、8A和8B、9A和9B、10、11A至11C以及12所示的运动阻件123。通常，运动阻件123被构造和布置成被动地控制纵向支架114的旋转运动。运动阻件123的优点包括缩小消融装置100的轮廓。缩小轮廓在进入受检对象的期望处理区域和/或从患者的期望处理区域取出消融装置100时是很有用的。例如，缩小轮廓的消融装置100可以使消融装置100在进入消化道1或从消化道1取出时几乎不会或不会被绊住或被挂住。因为纵向支架114通常能够以一个或多个自由度自由运动，运动阻件123可以有利地起到控制运动自由的作用。在一些实施方式中，运动阻件123包括联接或连接到纵向支架114上的弹性或超弹性结构。在其它实施方式中，运动阻件123包括各种其它机械部件，以便控制纵向支架114的旋转运动。
如图6所示，在一种实施方式中，运动阻件123包括弹簧。可以想到的是，弹簧可以是悬臂弹簧(如图6所示)、板簧、扭簧或本领域技术人员所知的任何弹簧类型。在一种实施方式中，如图6所示，悬臂弹簧形式的运动阻件123可以被构造和布置成限制纵向支架114相对于连接的内窥镜127的远端128的旋转运动。如所示，纵向支架114通常通过运动阻件123的弹簧保持在零点位置中。如本文中所用，“零点位置”意味着纵向支架114的纵向轴线基本上平行于连接到消融装置100上的内窥镜127或其它细长构件的纵向轴线。在一种实施方式中，运动阻件123连接到旋转支架底座上，或者底座的连接元件或带上。使得运动阻件123将预紧力施加到纵向支架上，迫使消融装置被锁定在相对于连接的内窥镜127(没有显示)的最低轮廓位置中。
运动阻件可以被构造和布置成抵抗纵向支架的旋转运动，并且依然允许纵向支架由于力的作用而从零点位置旋转偏离。在没有这样的力时，运动阻件的一些实施方式易于使纵向支架回复到零点位置。可以想到的是，运动阻件可以被构造和布置成影响纵向支架围绕一条或多条运动轴线的旋转运动。此外，可以想到的是，不同的运动轴线(例如x，y和z轴；见图1)受运动阻件的影响可以不同。
在一种实施方式中，如图7A和7B所示，运动阻件123可以包括包封导电线133的护套。所述护套可以由弹性或超弹性材料制成，弹性或超弹性材料包括但不限于例如硅酮。如图7B所示，护套式运动阻件123连接在纵向支架114的一端上。护套式运动阻件123的另一端能够通过例如套筒138(见图7A和7B)相对于内窥镜127或其它细长结构固定就位。在如图7A和7B所示的实施方式中，导电线133可以包括Z形图案。所述图案允许导电线133在运动阻件123拉伸时变长。
如图8A和8B所示，在另一种实施方式中，运动阻件123可以包括与纵向支架114联接或被连接到纵向支架上的弹性或超弹性材料带。适当的弹性或超弹性材料可以包括但不限于硅酮。如图8A所示，在一种实施方式中，运动阻件为套在纵向支架114的一部分上并且将其与内窥镜127连接在一起的弹性或超弹性材料的带。如图8B所示，在一种实施方式中，运动阻件123是将纵向支架114的一部分与内窥镜127连接的弹性或超弹性材料的带。在如图8B所示的示例中，所述带通过连接到内窥镜127上的套筒138连接到内窥镜127上。
在另一种实施方式中，如图9A和9B所示，运动阻件123可以包括连接到纵向支架114的一部分上的拉条或系绳。所述拉条或系绳的一部分可以通过安装在内窥镜127上的套筒138连接到内窥镜127上。当连接到消融装置100上的内窥镜127的远端128被布置成相对直的构型时，该实施方式的运动阻件123通常可以将纵向支架114保持在零点位置中。当内窥镜远端128如图9B所示偏转时，运动阻件123的拉条或系绳可以松弛或聚集在一起。在一种实施方式中，运动阻件123的拉条或系绳被构造和布置成在松弛时以手风琴的方式折叠(见图9B)。
在另一种实施方式中，如图10所示，运动阻件123可以包括指形件121部分和凹槽122部分。指形件121可以通过套筒138或其它连接部件连接到内窥镜127上，并且凹槽122可以包括在纵向支架114中。如图10所示，当连接到消融装置100上的内窥镜127的远端128被布置成相对直的构型时，指形件121可以与凹槽122接合，由此将纵向支架114保持在零点位置中。可以构造和布置指形件121和凹槽122，使得内窥镜远端128的偏转或将力施加到纵向支架114的部分上能够将指形件121从凹槽122可逆地释放。一旦指形件121被释放，纵向支架114就能自由地进行旋转运动。指形件121和凹槽122的重新连接再次将纵向支架114保持在零点位置中。
如图11A至11C所示，在一种实施方式中，运动阻件123为连接到部分纵向支架114的一部分上的裙板或裙裾，所述裙板或裙裾沿着被连接的内窥镜127的长度向近侧延伸。在该实施方式中，运动阻件123的裙板或裙裾装配在纵向支架114的近端上或与支架114的近端并置。该布置为纵向支架114的近侧部分提供了平滑轮廓。由于减少了支架114绊住或挂住组织表面的风险，这样的轮廓便于从处理区域取出消融装置100。运动阻件123可以如图11A所示连接到纵向支架114上或如图11B所示连接到纵向支架114上，或者作为变换方式不被连接。
可以想到的是，在单个消融装置中可以包括上述运动阻件的一个或多个，以便控制纵向支架的旋转运动。也可以想到的是，除了套筒连接之外，运动阻件的一部分与内窥镜、导管或其它结构的连接可以包括多种连接方式的任何连接方式。例如，运动阻件可以连接到内窥镜或导管或其元件(没有显示)的内侧或外侧表面上。
在一个方面中，消融装置100通常包括致动机构134，用于主动地控制纵向支架114的旋转(例如见图12)。通常，致动机构134允许在使纵向支架114受旋转约束和使支架114自由旋转之间相互转换。如图12所示，在一种实施方式中，致动机构134包括开关135以及拉条(或系绳)136。致动机构134的开关135可以联接到内窥镜127上，内窥镜127被连接到消融装置100上。拉条136可以联接到纵向支架114的一部分上。在如图12所示的实施方式中，致动机构134的开关135通过套筒138连接到内窥镜上并且可以定位在包括标示的位置“A”和“B”的一个或多个位置中。将致动机构134切换到位置“A”使得拉条136被拉紧并由此限制纵向支架114的旋转自由。而且，当在位置“A”中时，支架114被保持在零点位置中。如果将致动机构134切换到位置“B”，那么拉条136对纵向支架114的拉紧被释放，由此允许纵向支架114作旋转运动。
在另一种实施方式中，致动机构包括真空管线(没有显示)。在该实施方式中，纵向支架的旋转运动通过真空管线提供的抽吸力来控制，所述真空管线被构造和布置成使得当施加真空时纵向支架的近端部分固定不动。在没有真空时，纵向支架可以自由旋转。
在另一种实施方式中，致动机构被构造和布置成使得纵向支架的旋转运动受电磁体(没有显示)控制。在该实施方式中，施加电磁力导致纵向支架被固定在零点位置中。因此，当不再施加电磁力时，所述纵向支架能够自由旋转。
在一种实施方式中，消融装置为电极结构，所述电极结构被构造和布置成将包括射频能量的能量传递到消化道组织上。可以想到的是，这样的消融结构可以包括多个电极。例如，两个或更多个电极可以是消融结构的一部分。能量可以以适当量级传递以完成粘膜或粘膜下层组织的消融，或者换句话说使这些组织受损伤，同时基本保留肌肉组织。本文中所用的术语“消融”指的是引起组织或细胞坏死的组织热损伤。热损伤可以通过对组织加热或冷却(例如冷冻)实现。通常，在本发明这些实施方式中，消融用于将处理区域中的整个粘膜内层包括异常粘膜(例如异常柱状增生)从受影响的食管部分去除并且允许正常粘膜内层再生。有利的是，当使用这种方法时，治疗更加快速并且组织中狭窄的形成被减至最低。同样，电极消融元件可以允许流体(例如盐水)渗透通过纵向支架和/或电极，以防止组织在消融过程中粘附到电极上。
虽然射频能量是用于消融的能量的一种有利形式，但是应当理解的是，其它有利的能量形式包括例如微波能量或者光子源或辐射源(比如红外或紫外光)，光子源或辐射源可以结合改进的敏化剂。光子源可以包括半导体发射源、激光源和其他源。也应当理解，本发明的另一种实施方式可以使用可加热流体或冷却介质例如液氮、氟利昂
Figure A20068005220000151
非氟氯化碳(CFC)制冷剂或二氧化碳作为消融能量介质。为了使用热或冷流体或气体来消融，可以设想，消融系统可能需要一种用于将热/冷介质从患者体外循环到热/冷囊或其它元件然后再回到患者体外的装置。用于在低温外科探头中循环介质的装置在消融领域众所周知。例如，授予Dobak，III的专利号为No.6182666的美国专利、授予Li的专利号为No.6237355的美国专利和授予Kovalcheck等人的专利号为No.6572610的美国专利披露了适当的循环装置，以上专利通过引用结合入本文。
消融结构可以包括设置在消融结构上的电极双极阵列，所述电极双极阵列能够以双极形式传输射频能量。作为变换方式，消融结构可以包括单极电极结构，该单极电极结构可以通过射频电源与返回电极结合来供能，所述返回电极通常设置在患者皮肤(例如在腰背部)上。在任一情况下，射频能量在非常短的时间内以高能通量传输，从而仅仅损伤或消融粘膜组织或粘膜下层组织，而基本上不会加热或损伤肌肉组织。其中消融结构包括多个电极、一个或多个电极可以是双极或单极的。也可以是双极和单极电极的组合。
如图1A、3A、4A、5、6以及7A和7B所示，消融结构130的形状和尺寸可以以任何方式构造和布置。如图3A、4A、7A、7B和14A至14C所示，消融结构130可以包括电极阵列132。如果消融结构130包括电极阵列132，那么通常电极阵列的面积在大致0.5cm2到9.0cm2的范围内。典型的阵列形状可以包括正方形、矩形、圆形或椭圆形。在一种实施方式中，消融结构130的面积为2.5cm2。在另一种实施方式中，消融结构130的尺寸为2cm×2cm、面积为4cm2。
纵向支架被构造和布置成用于支承消融结构。支架114可以由能承受消融结构130产生的高能通量的任何适当材料制成。纵向支架可以是柔性的，能够围绕两条轴线旋转，由此还允许纵向支架旋转离开纵向轴线(没有显示)。在一种实施方式中，纵向支架由弹性材料(例如硅酮)制成。其它适当的材料包括氨基甲酸乙脂或其它聚合物材料。
如图3A、4A、4B、7A、7B和14A至14C所示，消融装置100还可以具有包括导线133的电连接件，以便将消融结构130连接到电源上。导线133可以如需要的那样包括单根线或多根线，以通过消融结构提供受控能量传输。在一种实施方式中，导线133包括低电损耗线例如李兹(litz)线。如图4A和4B所示，导线133可以缠绕或拉到纵向支架114的远端上并且从支架114下方穿过。通过防止对旋转运动的束缚或限制，这种布置有利地易化了纵向支架114的旋转运动。
如图4A、4B和14A至14C所示，消融装置100还可以包括一条或多条电极挽绳131。所述一条或多条电极挽绳131可以被构造和布置成与至少一部分纵向支架114相一致。所述一条或多条电极挽绳131可以与电极132和导线133形成电连接。可以设想到的是，挽绳131可以是电极132的延伸部分或者是单独元件。如图14A至14C所示，所述一条或多条挽绳131可以通过接头140特征与导线133形成电连接。如图所示，接头140可以连接到底座112的连接元件120上。可以设想到的是，导线133能够通过接头140可拆卸地连接到消融装置上，其中接头被构造和布置成例如电连接件。
也应当理解，本发明的另一种实施方式可以使用可加热流体或冷却介质例如液氮、氟利昂非氟氯化碳(CFC)制冷剂或二氧化碳作为消融能量介质。为了使用热或冷流体或气体来消融，可以设想到的是，消融系统可能需要一种用于将热/冷介质从患者体外循环到热/冷囊或其它元件然后再回到患者体外的装置。用于在低温外科探头中循环介质的装置在消融领域众所周知。例如，授予Dobak，III的专利号为No.6182666的美国专利、授予Dobak，III等人的专利号为No.6193644的美国专利、授予Li的专利号为No.6237355的美国专利和授予Kovalcheck等人的专利号为No.6572610的美国专利披露了适当的循环装置，以上专利通过引用结合入本文。
因此，在另一种实施方式中，如图4C所示，消融结构130可以被构造和布置成用于组织的低温消融。通常，通过提供用于输送冷却流体的导管或支架，纵向支架114可以支承或充当消融结构130，以便实现组织的低温消融。在一种实施方式中，消融结构可以是能够填充有流体或气体(没有显示)的囊或囊形结构。在另一种实施方式中，消融结构包括覆盖纵向支架的一部分或整个表面的膜盒或箱形元件，所述膜盒或箱形元件可以填充有流体或气体(没有显示)。在另一种实施方式中，纵向支架为部分或完全中空，用于容纳流体或气体。可以设想到的是，消融结构或纵向支架可以包括导热材料，用于促进热量传递以便实现组织的低温消融。还可以设想到的是，消融结构或纵向支架可以包括覆盖其整个或部分表面的导热元件。例如，适当的导热元件可以是薄金属表面，包括但不限于不锈钢或钛。
可以设想到的是，在一些实施方式中，消融结构或纵向支架可以被构造或布置成可被加热剂或冷却剂(没有显示)渗透。同样，还可以设想到的是，所述加热剂或冷却剂可以滤过消融结构或纵向支架，由此允许加热剂或冷却剂与组织表面直接接触。
如图4C所示，冷却流体到消融结构130的输送装置可以包括一条或多条管线144和可选的一个或多个端口142。管线144可以被构造和布置成输送流体(包括过冷流体)。端口142可以在管线144和消融结构130之间提供连接。端口142可以直接地联接到纵向支架114上。在一种实施方式中，端口联接到纵向支架上并且提供到消融结构的管线，所述消融结构与支架(没有显示)相连。作为变换方式，端口142可以直接联接到消融结构(没有显示)上。在一些实施方式中，管线144通过端口142连接到纵向支架114上(见图4C)。端口可以包括有利于通过获得压力差产生气态或液态相变的喷嘴或其它特征。
举例来说，如图4C所示，一种实施方式包括联接到端口142上的两条管线144。管线144都沿着连接的内窥镜127的长度延伸(在图4C所示的视图中只可见一条管线144沿着内窥镜127的长度延伸)。端口142直接连接到纵向支架114的底侧上，并且纵向支架114的上表面起消融结构130的作用。纵向支架114可以基本中空，以允许介质例如加热流体或冷却流体进入。
可选的是，所述装置的管线提供了用于流体流动到消融结构和从消融结构流出的回路。例如如图4C所示，在一种采用了两条管线144和两个端口142的实施方式中，一条管线144可以用作输入管线，而另一条管线可以用作输出管线。
在使用中，加热的或过冷流体可以通过输入管线输送至消融结构，由此激活消融结构。使用过冷流体激活消融结构可以包括引发液体至气体的相变，或着通过产生压力差例如压力降(理想气体定律：PV＝nRT)来引发相变。组织的低温消融可以通过使组织与过冷消融结构接触来实现。可选的是，可以通过使加热的或过冷流体介质连续或断续流入消融结构和从流出管线流出而保持加热流体或过冷流体介质在消融结构中的连续流动。如果需要，在消融后可以将所述介质从消融结构去除。可选的是，在去除过冷介质之后，可以将具有期望温度的另一种流体、气体或空气引入消融结构中。
通常，在另一方面中，在消化道1中消融组织的方法包括将包含消融结构130(在此为电极132)的消融装置100推进到消化道1中(见例如图4A)。消融结构130在消化道1内受到支架结构111的支承。至少一部分消融结构130可以从支架结构111旋转离开并且指向组织表面5。消融结构130可以如期望地那样被激活，以便消融组织表面5。
如图4A所示，在一种实施方式中，旋转至少一部分消融结构130(在此显示为电极132)包括在消融结构130(例如电极132)和组织表面5之间施加力。在另一种实施方式中，其中消融装置100包括多个消融结构130(见例如图5)，旋转步骤包括在一个或多个消融结构130和组织表面5之间施加力。
在消化道中消融组织的方法还包括围绕至少一条旋转轴线和/或围绕至少两条旋转轴线和/或围绕至少三条旋转轴线旋转至少一部分消融结构。如上详细所述，消融装置可以被构造和布置成支持这样的运动。例如如图1所示，消融装置100的支架结构111可以包括纵向支架114和旋转支架116。消融结构130受到纵向支架114的支承，同时旋转支架116能够允许至少一部分消融结构130旋转。以上详细描述了与本发明方法的消融结构130的旋转运动有关的各种结构。
在另一种实施方式中，旋转至少一部分消融结构的方法包括限制消融结构的旋转范围。以上描述了与限制围绕x、y和z轴旋转范围有关的特征的各种结构。例如，公开了各种旋转支架，其提供了相对于x、y和z轴的运动自由度。
在另一种实施方式中，所述方法包括在旋转消融结构的同时抵抗消融结构的旋转运动。如上所述，消融装置可以包括各种运动阻件结构特征，所述运动阻件结构特征被构造和布置成抵抗消融结构的旋转运动。例如，公开了对纵向支架以及消融结构的旋转运动的控制的运动阻件。
在一种实施方式中，如图4A所示，推进消融结构130的步骤包括将内窥镜127推进到消化道1中。一种市场上能买到的传统内窥镜127的示例是型号为GIF-Q160的奥林巴斯“胃内窥镜(gastrovideoscope)”。虽然尤其是能在市场上买到的内窥镜的具体结构是不同的，但是如图13所示，绝大多数内窥镜包括轴164，该轴164具有可控远端128和集线器或手柄162，所述集线器或手柄162包括用于连接到显示屏160上的视频通道161和提供访问轴164内的内部工作通道的端口166。电源159可以通过电缆165将能量提供给内窥镜127。正如内窥镜领域中常见的那样，刻度盘、杠杆或其它机构(没有显示)通常被设置在手柄162上以便操作者有选择地控制内窥镜127的远端110。在使用中，其中消融装置100联接或连接到内窥镜127上，可以将所述组合引入到消化道中并且在消化道内推进。在一种变换实施方式中，推进消融结构的步骤包括将导管推进到消化道中(没有显示)。
如图4A所示，在一种实施方式中，所述方法包括使用内窥镜127支承消融结构(显示为电极132)。在使用中，如图4A所示，包括消融结构(显示为电极132)的消融装置100可以连接到内窥镜远端128上用于支承消融装置。如上具体所述，在一些实施方式中，旋转支架116还包括底座112，所述底座112被构造和布置成将消融装置100连接到内窥镜127上。同样，底座112可以提供连接点，用于通过内窥镜127来支承消融装置100。
在另一种方法中，将包括消融结构的消融装置推进到消化道中的步骤包括将内窥镜推进到消化道中并且在内窥镜上推进消融装置。例如，可以相对于消融目标组织定位内窥镜，随后可以在内窥镜的外侧上推进消融装置以便消融目标组织。
在另一种方法中，支承消融装置的步骤可以包括在将消融装置推进到消化道中之后将内窥镜插入到消融装置中。如2005年11月23日提交的共同未决的美国专利申请Nos.11/286257和11/286444中具体公开的那样，各种变型和构造的消融装置可以装配在内窥镜内部工作通道并且在其中输送通过，所述专利申请的所有公开内容通过引用结合入本文。同样，作为变换方式，消融装置的消融结构可以通过内窥镜的内部工作通道来支承。可以设想到的是，本文所述的用于支承消融装置的方法的任何组合都是可能的。
在本发明的另一种方法中，其中消融结构是至少一个电极，激活消融结构的步骤可以包括通过电连接件将电能提供给电极(见例如3A、4A、4B、7A、7B和14A至14C)。
虽然本文中显示和描述了本发明的优选实施方式，但是对于本领域技术人员而言显然只是示意性的。在不脱离本发明的情况下，本领域技术人员会想到大量变型、变化和替换。应当理解的是在实施本发明的过程中可以采用本文所述的本发明实施方式的各种变换形式。旨在用下面的权利要求限定本发明的范围，由此覆盖在所述权利要求的范围内的方法和结构及其等同物。

Claims (13)

1.一种消融装置，包括：
消融结构；和
支架结构，其能够在患者消化道内支承所述消融结构，所述支架结构包括旋转支架和具有纵向轴线的纵向支架，所述旋转支架能够允许所述消融结构的至少一部分相对于所述纵向支架的纵向轴线运动，所述旋转支架包括运动阻件。
2.如权利要求1所述的装置，其中，所述旋转支架能够以至少一个自由度旋转。
3.如权利要求1所述的装置，其中，所述旋转支架能够以至少两个自由度旋转。
4.如权利要求1所述的装置，其中，所述旋转支架能够以至少三个自由度旋转。
5.如权利要求1所述的装置，其中，所述旋转支架还包括能够限制转动范围的挡块构件。
6.如权利要求1所述的装置，其中，所述运动阻件包括弹簧。
7.如权利要求1所述的装置，其中，所述运动阻件包括能够防止所述消融结构作旋转运动的锁止件。
8.如权利要求1所述的装置，还包括能够防止所述消融结构作旋转运动的致动机构。
9.如权利要求1所述的装置，其中，所述支架结构包括内窥镜。
10.如权利要求1所述的装置，其中，所述支架结构包括导管。
11.如权利要求1所述的装置，其中，所述消融结构包括至少一个电极。
12.如权利要求1所述的装置，还包括由所述支架结构支承的多个消融结构。
13.如权利要求1所述的装置，其中，所述消融结构能够对组织进行低温消融。
CN2006800522005A 2005-12-20 2006-12-20 自动对准的消融装置及其使用方法 Active CN101563042B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/275,244 2005-12-20
US11/275,244 US8702694B2 (en) 2005-11-23 2005-12-20 Auto-aligning ablating device and method of use
PCT/US2006/048719 WO2007097805A2 (en) 2005-12-20 2006-12-20 Auto-aligning ablating device and method of use

Publications (2)

Publication Number Publication Date
CN101563042A true CN101563042A (zh) 2009-10-21
CN101563042B CN101563042B (zh) 2011-07-13

Family

ID=38437823

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800522005A Active CN101563042B (zh) 2005-12-20 2006-12-20 自动对准的消融装置及其使用方法

Country Status (11)

Country Link
US (4) US8702694B2 (zh)
EP (2) EP1968471B1 (zh)
JP (2) JP5227183B2 (zh)
KR (1) KR101334890B1 (zh)
CN (1) CN101563042B (zh)
AU (1) AU2006338555B2 (zh)
BR (1) BRPI0620168B8 (zh)
CA (1) CA2633687C (zh)
HK (1) HK1122203A1 (zh)
MX (1) MX2008008123A (zh)
WO (1) WO2007097805A2 (zh)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103200890A (zh) * 2010-10-29 2013-07-10 麦德托尼克消融前沿有限公司 低温射频消融系统
CN104220020A (zh) * 2011-12-21 2014-12-17 纽华沃医药公司 能量输送系统及其用途
US9861440B2 (en) 2010-05-03 2018-01-09 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US9877783B2 (en) 2009-07-28 2018-01-30 Neuwave Medical, Inc. Energy delivery systems and uses thereof
CN108882957A (zh) * 2016-02-10 2018-11-23 埃米尔·丹尼尔·贝尔森 个性化的心房颤动消融
US10363092B2 (en) 2006-03-24 2019-07-30 Neuwave Medical, Inc. Transmission line with heat transfer ability
US10376314B2 (en) 2006-07-14 2019-08-13 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US10531917B2 (en) 2016-04-15 2020-01-14 Neuwave Medical, Inc. Systems and methods for energy delivery
US10952792B2 (en) 2015-10-26 2021-03-23 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11389235B2 (en) 2006-07-14 2022-07-19 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11672596B2 (en) 2018-02-26 2023-06-13 Neuwave Medical, Inc. Energy delivery devices with flexible and adjustable tips
US11832879B2 (en) 2019-03-08 2023-12-05 Neuwave Medical, Inc. Systems and methods for energy delivery

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740082B2 (en) * 1998-12-29 2004-05-25 John H. Shadduck Surgical instruments for treating gastro-esophageal reflux
US20040215235A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. Methods and systems for determining physiologic characteristics for treatment of the esophagus
WO2001035846A1 (en) 1999-11-16 2001-05-25 Ganz Robert A System and method of treating abnormal tissue in the human esophagus
US20060095032A1 (en) 1999-11-16 2006-05-04 Jerome Jackson Methods and systems for determining physiologic characteristics for treatment of the esophagus
US7150745B2 (en) 2004-01-09 2006-12-19 Barrx Medical, Inc. Devices and methods for treatment of luminal tissue
US7997278B2 (en) 2005-11-23 2011-08-16 Barrx Medical, Inc. Precision ablating method
US8702694B2 (en) 2005-11-23 2014-04-22 Covidien Lp Auto-aligning ablating device and method of use
BRPI0618981A2 (pt) * 2005-11-23 2011-09-20 Barrx Medical Inc dispositivo de ablação
US8641711B2 (en) * 2007-05-04 2014-02-04 Covidien Lp Method and apparatus for gastrointestinal tract ablation for treatment of obesity
US8784338B2 (en) 2007-06-22 2014-07-22 Covidien Lp Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size
US8251992B2 (en) 2007-07-06 2012-08-28 Tyco Healthcare Group Lp Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation
EP2170202A1 (en) 2007-07-06 2010-04-07 Barrx Medical, Inc. Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding
US8273012B2 (en) 2007-07-30 2012-09-25 Tyco Healthcare Group, Lp Cleaning device and methods
US8646460B2 (en) * 2007-07-30 2014-02-11 Covidien Lp Cleaning device and methods
US10278774B2 (en) 2011-03-18 2019-05-07 Covidien Lp Selectively expandable operative element support structure and methods of use
WO2013040175A2 (en) 2011-09-13 2013-03-21 Tyco Health Care Group Lp Operative element support structure and method
US9364277B2 (en) 2012-12-13 2016-06-14 Cook Medical Technologies Llc RF energy controller and method for electrosurgical medical devices
US9204921B2 (en) 2012-12-13 2015-12-08 Cook Medical Technologies Llc RF energy controller and method for electrosurgical medical devices
CA2868603A1 (en) * 2013-10-25 2015-04-25 Covidien Lp Unfurling electrode devices with the multiple longitudinal electrode segments
US20150119877A1 (en) * 2013-10-25 2015-04-30 Covidien Lp Electrode ablation balloon catheter
US10610279B2 (en) 2014-04-10 2020-04-07 Channel Medsystems, Inc. Apparatus and methods for regulating cryogenic treatment
US20150342669A1 (en) * 2014-05-29 2015-12-03 Boston Scientific Scimed, Inc. Devices and methods for controlled energy delivery to airways
WO2017117582A1 (en) 2015-12-30 2017-07-06 Schuler Scientific Solutions, Llc Tissue mapping and treatment
AU2018204259B2 (en) * 2017-06-29 2019-08-15 Covidien Lp Systems and methods for ablative treatment of irritable bowel disease
US11786296B2 (en) * 2019-02-15 2023-10-17 Accularent, Inc. Instrument for endoscopic posterior nasal nerve ablation

Family Cites Families (456)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US552832A (en) * 1896-01-07 Instrument for treatment of strictures by electrolysis
US1798902A (en) 1928-11-05 1931-03-31 Edwin M Raney Surgical instrument
US3517128A (en) 1968-02-08 1970-06-23 James R Hines Surgical expanding arm dilator
US3924628A (en) 1972-12-01 1975-12-09 William Droegemueller Cyrogenic bladder for necrosing tissue cells
US3901241A (en) 1973-05-31 1975-08-26 Al Corp Du Disposable cryosurgical instrument
DE2513868C2 (de) 1974-04-01 1982-11-04 Olympus Optical Co., Ltd., Tokyo Bipolare Elektrodiathermiefaßzange
JPS553181Y2 (zh) 1975-08-20 1980-01-25
US4196724A (en) 1978-01-31 1980-04-08 Frecker William H Tongue locking device
US4311154A (en) * 1979-03-23 1982-01-19 Rca Corporation Nonsymmetrical bulb applicator for hyperthermic treatment of the body
US4304239A (en) 1980-03-07 1981-12-08 The Kendall Company Esophageal probe with balloon electrode
WO1981003271A1 (en) 1980-05-13 1981-11-26 American Hospital Supply Corp A multipolar electrosurgical device
DK238080A (da) * 1980-06-03 1981-12-04 P Pless Spiseroers-stimulationssonde til elektrisk stimulation af hjertet
JPS5755573A (en) 1980-09-18 1982-04-02 Olympus Optical Co Ltd Cassette storing device
US4411266A (en) 1980-09-24 1983-10-25 Cosman Eric R Thermocouple radio frequency lesion electrode
US4565200A (en) 1980-09-24 1986-01-21 Cosman Eric R Universal lesion and recording electrode system
US4407298A (en) 1981-07-16 1983-10-04 Critikon Inc. Connector for thermodilution catheter
US5385544A (en) 1992-08-12 1995-01-31 Vidamed, Inc. BPH ablation method and apparatus
US5435805A (en) 1992-08-12 1995-07-25 Vidamed, Inc. Medical probe device with optical viewing capability
US5542915A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Thermal mapping catheter with ultrasound probe
US5370675A (en) 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US5421819A (en) 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
EP0105677B1 (en) 1982-09-27 1986-12-10 Kureha Kagaku Kogyo Kabushiki Kaisha Endotract antenna device for hyperthermia
JPS5957650A (ja) * 1982-09-27 1984-04-03 呉羽化学工業株式会社 腔内加熱用プロ−ブ
US4541423A (en) * 1983-01-17 1985-09-17 Barber Forest C Drilling a curved hole
CA1244889A (en) 1983-01-24 1988-11-15 Kureha Chemical Ind Co Ltd HYPERTHERMIA DEVICE
JPS6055966A (ja) 1983-09-05 1985-04-01 オリンパス光学工業株式会社 医用電極装置
US4601296A (en) 1983-10-07 1986-07-22 Yeda Research And Development Co., Ltd. Hyperthermia apparatus
US4674481A (en) 1983-10-31 1987-06-23 Board Of Regents, The University Of Texas System RF electromagnetic field generation apparatus for regionally-focused hyperthermia
US4705041A (en) 1984-07-06 1987-11-10 Kim Il G Dilator for Sphincter of Oddi
US5019075A (en) 1984-10-24 1991-05-28 The Beth Israel Hospital Method and apparatus for angioplasty
JPH0644105B2 (ja) 1985-01-14 1994-06-08 オリンパス光学工業株式会社 内視鏡
US4658836A (en) * 1985-06-28 1987-04-21 Bsd Medical Corporation Body passage insertable applicator apparatus for electromagnetic
FR2586141B1 (fr) 1985-08-06 1987-11-20 Thomson Csf Thyristor sensible a decouplage gachette-cathode integre
AT385894B (de) 1985-10-04 1988-05-25 Basem Dr Nashef Schlauchfoermige sonde
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
JPH0311011Y2 (zh) 1986-06-27 1991-03-18
US4740207A (en) * 1986-09-10 1988-04-26 Kreamer Jeffry W Intralumenal graft
US5231995A (en) 1986-11-14 1993-08-03 Desai Jawahar M Method for catheter mapping and ablation
US5215103A (en) 1986-11-14 1993-06-01 Desai Jawahar M Catheter for mapping and ablation and method therefor
US5365926A (en) 1986-11-14 1994-11-22 Desai Jawahar M Catheter for mapping and ablation and method therefor
US4765331A (en) 1987-02-10 1988-08-23 Circon Corporation Electrosurgical device with treatment arc of less than 360 degrees
US4901737A (en) 1987-04-13 1990-02-20 Toone Kent J Method and therapeutic apparatus for reducing snoring
US5888743A (en) * 1987-04-24 1999-03-30 Das; Kiron M. In vitro method for diagnosing benign Barrett's Epithelium
US4960106A (en) 1987-04-28 1990-10-02 Olympus Optical Co., Ltd. Endoscope apparatus
US4823791A (en) * 1987-05-08 1989-04-25 Circon Acmi Division Of Circon Corporation Electrosurgical probe apparatus
US4943290A (en) 1987-06-23 1990-07-24 Concept Inc. Electrolyte purging electrode tip
JPH088933B2 (ja) 1987-07-10 1996-01-31 日本ゼオン株式会社 カテ−テル
JPS6446056U (zh) 1987-09-17 1989-03-22
US4860744A (en) 1987-11-02 1989-08-29 Raj K. Anand Thermoelectrically controlled heat medical catheter
FR2624747A1 (fr) * 1987-12-18 1989-06-23 Delsanti Gerard Dispositifs endo-arteriels amovibles destines a reparer des decollements de parois des arteres
US5372138A (en) 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
US5588432A (en) 1988-03-21 1996-12-31 Boston Scientific Corporation Catheters for imaging, sensing electrical potentials, and ablating tissue
US4907589A (en) 1988-04-29 1990-03-13 Cosman Eric R Automatic over-temperature control apparatus for a therapeutic heating device
DE3821544C2 (de) 1988-06-25 1994-04-28 H Prof Dr Med Just Dilatationskatheter
US4896138A (en) * 1988-07-15 1990-01-23 Nickols Paul G Bicycle braking indicator light assembly
US4947842A (en) 1988-09-22 1990-08-14 Medical Engineering And Development Institute, Inc. Method and apparatus for treating tissue with first and second modalities
US4906203A (en) 1988-10-24 1990-03-06 General Motors Corporation Electrical connector with shorting clip
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US5151100A (en) 1988-10-28 1992-09-29 Boston Scientific Corporation Heating catheters
US4966597A (en) 1988-11-04 1990-10-30 Cosman Eric R Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection
DE3838840C2 (de) 1988-11-17 1997-02-20 Leibinger Gmbh Hochfrequenzkoagulationsvorrichtung für chirurgische Zwecke
AU4945490A (en) 1989-01-06 1990-08-01 Angioplasty Systems Inc. Electrosurgical catheter for resolving atherosclerotic plaque
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
CA1332905C (en) 1989-03-10 1994-11-08 John A. Murchie Method and apparatus for treatment of snoring
US5458571A (en) 1989-03-17 1995-10-17 Merit Medical Systems, Inc. System and method for monitoring, displaying and recording balloon catheter condition interval data
US4930521A (en) 1989-03-17 1990-06-05 Metzger William T Variable stiffness esophageal catheter
US5057107A (en) 1989-04-13 1991-10-15 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5078717A (en) 1989-04-13 1992-01-07 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US4979948A (en) 1989-04-13 1990-12-25 Purdue Research Foundation Method and apparatus for thermally destroying a layer of an organ
US5151085A (en) 1989-04-28 1992-09-29 Olympus Optical Co., Ltd. Apparatus for generating ultrasonic oscillation
DE3915636C1 (zh) 1989-05-12 1990-04-26 Sass, Wolfgang, Dr.
US5006119A (en) * 1989-05-25 1991-04-09 Engineering & Research Associates, Inc. Hollow core coaxial catheter
US5084044A (en) 1989-07-14 1992-01-28 Ciron Corporation Apparatus for endometrial ablation and method of using same
US5056532A (en) 1989-07-25 1991-10-15 Medtronic, Inc. Esophageal pacing lead
WO1991001773A1 (en) 1989-08-01 1991-02-21 Enrico Mangieri Percutaneous mechanical dilating catheter for cardiac valves and blood vessels
US5010895A (en) * 1989-08-03 1991-04-30 Empi, Inc. Expandable vaginal electrode
US5057105A (en) 1989-08-28 1991-10-15 The University Of Kansas Med Center Hot tip catheter assembly
EP0490979B1 (en) 1989-09-08 1996-11-13 Boston Scientific Corporation Physiologic low stress angioplasty
US5045056A (en) 1989-09-15 1991-09-03 Behl Robert S Method and device for thermal ablation of hollow body organs
US5117828A (en) 1989-09-25 1992-06-02 Arzco Medical Electronics, Inc. Expandable esophageal catheter
US5035696A (en) 1990-02-02 1991-07-30 Everest Medical Corporation Electrosurgical instrument for conducting endoscopic retrograde sphincterotomy
US5205287A (en) 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5122137A (en) 1990-04-27 1992-06-16 Boston Scientific Corporation Temperature controlled rf coagulation
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5482054A (en) * 1990-05-10 1996-01-09 Symbiosis Corporation Edoscopic biopsy forceps devices with selective bipolar cautery
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
US5163938A (en) 1990-07-19 1992-11-17 Olympus Optical Co., Ltd. High-frequency surgical treating device for use with endoscope
US5083565A (en) 1990-08-03 1992-01-28 Everest Medical Corporation Electrosurgical instrument for ablating endocardial tissue
US5100423A (en) 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
US5428658A (en) 1994-01-21 1995-06-27 Photoelectron Corporation X-ray source with flexible probe
AU664157B2 (en) * 1990-09-14 1995-11-09 American Medical Systems, Inc. Combined hyperthermia and dilation catheter
EP0503019B1 (fr) 1990-10-03 1996-03-27 TRUFFER, Ernest Appareil preventif du ronflement
US5256138A (en) 1990-10-04 1993-10-26 The Birtcher Corporation Electrosurgical handpiece incorporating blade and conductive gas functionality
US5088979A (en) 1990-10-11 1992-02-18 Wilson-Cook Medical Inc. Method for esophageal invagination and devices useful therein
US5190541A (en) 1990-10-17 1993-03-02 Boston Scientific Corporation Surgical instrument and method
WO1992010142A1 (en) 1990-12-10 1992-06-25 Howmedica Inc. A device and method for interstitial laser energy delivery
US5094233A (en) 1991-01-11 1992-03-10 Brennan Louis G Turbinate sheath device
US5368557A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having multiple ultrasound transmission members
US5720293A (en) * 1991-01-29 1998-02-24 Baxter International Inc. Diagnostic catheter with memory
US5409453A (en) 1992-08-12 1995-04-25 Vidamed, Inc. Steerable medical probe with stylets
US5156151A (en) 1991-02-15 1992-10-20 Cardiac Pathways Corporation Endocardial mapping and ablation system and catheter probe
US5465717A (en) 1991-02-15 1995-11-14 Cardiac Pathways Corporation Apparatus and Method for ventricular mapping and ablation
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5345936A (en) 1991-02-15 1994-09-13 Cardiac Pathways Corporation Apparatus with basket assembly for endocardial mapping
US5370901A (en) 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US5275610A (en) 1991-05-13 1994-01-04 Cook Incorporated Surgical retractors and method of use
US5542928A (en) 1991-05-17 1996-08-06 Innerdyne, Inc. Method and device for thermal ablation having improved heat transfer
FI93607C (fi) * 1991-05-24 1995-05-10 John Koivukangas Leikkaustoimenpidelaite
AU1899292A (en) 1991-05-24 1993-01-08 Ep Technologies Inc Combination monophasic action potential/ablation catheter and high-performance filter system
US5383917A (en) 1991-07-05 1995-01-24 Jawahar M. Desai Device and method for multi-phase radio-frequency ablation
US5171299A (en) 1991-08-02 1992-12-15 Baxter International Inc. Balloon catheter inflation pressure and diameter display apparatus and method
EP0566710A1 (de) 1991-09-26 1993-10-27 Hans BÄR Medizintechnisches verfahren zur messung der durchblutung eines organs und mittel dazu
US5275608A (en) 1991-10-16 1994-01-04 Implemed, Inc. Generic endoscopic instrument
US5976129A (en) 1991-10-18 1999-11-02 Desai; Ashvin H. Endoscopic surgical instrument
CA2106410C (en) 1991-11-08 2004-07-06 Stuart D. Edwards Ablation electrode with insulated temperature sensing elements
AU3128593A (en) 1991-11-08 1993-06-07 Ep Technologies Inc Radiofrequency ablation with phase sensitive power detection
US5257451A (en) 1991-11-08 1993-11-02 Ep Technologies, Inc. Method of making durable sleeve for enclosing a bendable electrode tip assembly
US5363861A (en) 1991-11-08 1994-11-15 Ep Technologies, Inc. Electrode tip assembly with variable resistance to bending
US5275162A (en) 1991-11-08 1994-01-04 Ep Technologies, Inc. Valve mapping catheter
US5328467A (en) 1991-11-08 1994-07-12 Ep Technologies, Inc. Catheter having a torque transmitting sleeve
US5383874A (en) 1991-11-08 1995-01-24 Ep Technologies, Inc. Systems for identifying catheters and monitoring their use
US5197964A (en) 1991-11-12 1993-03-30 Everest Medical Corporation Bipolar instrument utilizing one stationary electrode and one movable electrode
JPH0541509U (ja) 1991-11-13 1993-06-08 オリンパス光学工業株式会社 内視鏡用電気凝固治療具
US5197963A (en) 1991-12-02 1993-03-30 Everest Medical Corporation Electrosurgical instrument with extendable sheath for irrigation and aspiration
US5433725A (en) * 1991-12-13 1995-07-18 Unisurge, Inc. Hand-held surgical device and tools for use therewith, assembly and method
US5192297A (en) * 1991-12-31 1993-03-09 Medtronic, Inc. Apparatus and method for placement and implantation of a stent
US5902272A (en) * 1992-01-07 1999-05-11 Arthrocare Corporation Planar ablation probe and method for electrosurgical cutting and ablation
US6355032B1 (en) * 1995-06-07 2002-03-12 Arthrocare Corporation Systems and methods for selective electrosurgical treatment of body structures
US6053172A (en) * 1995-06-07 2000-04-25 Arthrocare Corporation Systems and methods for electrosurgical sinus surgery
US5275169A (en) * 1992-01-15 1994-01-04 Innovation Associates Apparatus and method for determining physiologic characteristics of body lumens
US5242441A (en) 1992-02-24 1993-09-07 Boaz Avitall Deflectable catheter with rotatable tip electrode
US5263493A (en) 1992-02-24 1993-11-23 Boaz Avitall Deflectable loop electrode array mapping and ablation catheter for cardiac chambers
US5480644A (en) 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
US5413588A (en) 1992-03-06 1995-05-09 Urologix, Inc. Device and method for asymmetrical thermal therapy with helical dipole microwave antenna
US5281216A (en) 1992-03-31 1994-01-25 Valleylab, Inc. Electrosurgical bipolar treating apparatus
WO1993020768A1 (en) 1992-04-13 1993-10-28 Ep Technologies, Inc. Steerable microwave antenna systems for cardiac ablation
US5281217A (en) 1992-04-13 1994-01-25 Ep Technologies, Inc. Steerable antenna systems for cardiac ablation that minimize tissue damage and blood coagulation due to conductive heating patterns
WO1993020886A1 (en) 1992-04-13 1993-10-28 Ep Technologies, Inc. Articulated systems for cardiac ablation
US5314466A (en) 1992-04-13 1994-05-24 Ep Technologies, Inc. Articulated unidirectional microwave antenna systems for cardiac ablation
US5443470A (en) 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5562720A (en) 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
US5277201A (en) * 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5255679A (en) 1992-06-02 1993-10-26 Cardiac Pathways Corporation Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method
US5324284A (en) 1992-06-05 1994-06-28 Cardiac Pathways, Inc. Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method
US5281218A (en) 1992-06-05 1994-01-25 Cardiac Pathways Corporation Catheter having needle electrode for radiofrequency ablation
US5254126A (en) 1992-06-24 1993-10-19 Ethicon, Inc. Endoscopic suture punch
US5411025A (en) * 1992-06-30 1995-05-02 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array
WO1994002077A2 (en) 1992-07-15 1994-02-03 Angelase, Inc. Ablation catheter system
US5486161A (en) 1993-02-02 1996-01-23 Zomed International Medical probe device and method
US5484400A (en) 1992-08-12 1996-01-16 Vidamed, Inc. Dual channel RF delivery system
US5556377A (en) 1992-08-12 1996-09-17 Vidamed, Inc. Medical probe apparatus with laser and/or microwave monolithic integrated circuit probe
US5672153A (en) 1992-08-12 1997-09-30 Vidamed, Inc. Medical probe device and method
US5542916A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Dual-channel RF power delivery system
US5514131A (en) 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5470308A (en) 1992-08-12 1995-11-28 Vidamed, Inc. Medical probe with biopsy stylet
US5456662A (en) 1993-02-02 1995-10-10 Edwards; Stuart D. Method for reducing snoring by RF ablation of the uvula
US5720718A (en) 1992-08-12 1998-02-24 Vidamed, Inc. Medical probe apparatus with enhanced RF, resistance heating, and microwave ablation capabilities
US5275615A (en) * 1992-09-11 1994-01-04 Anthony Rose Medical instrument having gripping jaws
US5772597A (en) 1992-09-14 1998-06-30 Sextant Medical Corporation Surgical tool end effector
US5313943A (en) 1992-09-25 1994-05-24 Ep Technologies, Inc. Catheters and methods for performing cardiac diagnosis and treatment
US5401272A (en) 1992-09-25 1995-03-28 Envision Surgical Systems, Inc. Multimodality probe with extendable bipolar electrodes
US5309910A (en) 1992-09-25 1994-05-10 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5293869A (en) 1992-09-25 1994-03-15 Ep Technologies, Inc. Cardiac probe with dynamic support for maintaining constant surface contact during heart systole and diastole
US5416020A (en) 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US5471982A (en) 1992-09-29 1995-12-05 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5305696A (en) 1992-10-05 1994-04-26 Mendenhall Robert Lamar Process and system for treating contaminated particulate soil compositions
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
US5334196A (en) 1992-10-05 1994-08-02 United States Surgical Corporation Endoscopic fastener remover
US5415657A (en) 1992-10-13 1995-05-16 Taymor-Luria; Howard Percutaneous vascular sealing method
US5360432A (en) * 1992-10-16 1994-11-01 Shturman Cardiology Systems, Inc. Abrasive drive shaft device for directional rotational atherectomy
US5342357A (en) 1992-11-13 1994-08-30 American Cardiac Ablation Co., Inc. Fluid cooled electrosurgical cauterization system
WO1994010924A1 (en) 1992-11-13 1994-05-26 American Cardiac Ablation Co., Inc. Fluid cooled electrosurgical probe
US5348554A (en) 1992-12-01 1994-09-20 Cardiac Pathways Corporation Catheter for RF ablation with cooled electrode
US5409483A (en) 1993-01-22 1995-04-25 Jeffrey H. Reese Direct visualization surgical probe
CN1119418A (zh) 1993-02-02 1996-03-27 怀达医疗公司 经由尿道的针式切除装置和方法
DE4303882C2 (de) 1993-02-10 1995-02-09 Kernforschungsz Karlsruhe Kombinationsinstrument zum Trennen und Koagulieren für die minimal invasive Chirurgie
US5636634A (en) 1993-03-16 1997-06-10 Ep Technologies, Inc. Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes
US5330488A (en) 1993-03-23 1994-07-19 Goldrath Milton H Verres needle suturing kit
US5336222A (en) 1993-03-29 1994-08-09 Boston Scientific Corporation Integrated catheter for diverse in situ tissue therapy
US5403311A (en) 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US5375594A (en) 1993-03-29 1994-12-27 Cueva; Roberto A. Removable medical electrode system
CA2136988A1 (en) 1993-04-07 1994-10-13 Mir A. Imran Apparatus and method for ventricular mapping and ablation
US5365945A (en) 1993-04-13 1994-11-22 Halstrom Leonard W Adjustable dental applicance for treatment of snoring and obstructive sleep apnea
US5716410A (en) * 1993-04-30 1998-02-10 Scimed Life Systems, Inc. Temporary stent and method of use
US6832996B2 (en) 1995-06-07 2004-12-21 Arthrocare Corporation Electrosurgical systems and methods for treating tissue
EP0703756B1 (en) 1993-06-10 2004-12-15 IMRAN, Mir, A. Transurethral radio frequency ablation apparatus
US5800334A (en) 1993-06-17 1998-09-01 Wilk; Peter J. Intrapericardial assist device and associated method
US5533958A (en) 1993-06-17 1996-07-09 Wilk; Peter J. Intrapericardial assist device and associated method
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
DE4323585A1 (de) * 1993-07-14 1995-01-19 Delma Elektro Med App Bipolares Hochfrequenz-Chirurgieinstrument
US5738096A (en) 1993-07-20 1998-04-14 Biosense, Inc. Cardiac electromechanics
US5400783A (en) * 1993-10-12 1995-03-28 Cardiac Pathways Corporation Endocardial mapping apparatus with rotatable arm and method
US5582609A (en) * 1993-10-14 1996-12-10 Ep Technologies, Inc. Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
WO1995010320A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Device for lengthening cardiac conduction pathways
WO1995010322A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Creating complex lesion patterns in body tissue
US5797903A (en) 1996-04-12 1998-08-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with electrically conductive surfaces
WO1995010978A1 (en) 1993-10-19 1995-04-27 Ep Technologies, Inc. Segmented electrode assemblies for ablation of tissue
US5776146A (en) 1993-10-20 1998-07-07 Applied Medical Resources Laparoscopic surgical clamp
US5433739A (en) 1993-11-02 1995-07-18 Sluijter; Menno E. Method and apparatus for heating an intervertebral disc for relief of back pain
US5507743A (en) 1993-11-08 1996-04-16 Zomed International Coiled RF electrode treatment apparatus
US5458597A (en) 1993-11-08 1995-10-17 Zomed International Device for treating cancer and non-malignant tumors and methods
US5472441A (en) 1993-11-08 1995-12-05 Zomed International Device for treating cancer and non-malignant tumors and methods
US5536267A (en) 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US5683384A (en) 1993-11-08 1997-11-04 Zomed Multiple antenna ablation apparatus
US5599345A (en) * 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
EP1364677A3 (en) 1993-11-10 2006-12-27 Medtronic, Inc. Electrode array catheter
WO1995015046A1 (en) 1993-11-26 1995-06-01 Octel Communications Corporation Exchange of information between interconnected voicemail systems
US5730127A (en) 1993-12-03 1998-03-24 Avitall; Boaz Mapping and ablation catheter system
WO1995020345A1 (en) 1994-01-28 1995-08-03 Ep Technologies, Inc. Minimizing blood contact in cardiac tissue measurements
US5462545A (en) 1994-01-31 1995-10-31 New England Medical Center Hospitals, Inc. Catheter electrodes
US5423812A (en) 1994-01-31 1995-06-13 Ellman; Alan G. Electrosurgical stripping electrode for palatopharynx tissue
US5517989A (en) * 1994-04-01 1996-05-21 Cardiometrics, Inc. Guidewire assembly
US5458596A (en) 1994-05-06 1995-10-17 Dorsal Orthopedic Corporation Method and apparatus for controlled contraction of soft tissue
US5575788A (en) 1994-06-24 1996-11-19 Stuart D. Edwards Thin layer ablation apparatus
US5505730A (en) 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US5746224A (en) 1994-06-24 1998-05-05 Somnus Medical Technologies, Inc. Method for ablating turbinates
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US5823197A (en) 1994-06-24 1998-10-20 Somnus Medical Technologies, Inc. Method for internal ablation of turbinates
US6044846A (en) 1994-06-24 2000-04-04 Edwards; Stuart D. Method to treat esophageal sphincters
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US6092528A (en) 1994-06-24 2000-07-25 Edwards; Stuart D. Method to treat esophageal sphincters
US6006755A (en) 1994-06-24 1999-12-28 Edwards; Stuart D. Method to detect and treat aberrant myoelectric activity
US5681308A (en) 1994-06-24 1997-10-28 Stuart D. Edwards Ablation apparatus for cardiac chambers
US5566221A (en) 1994-07-12 1996-10-15 Photoelectron Corporation Apparatus for applying a predetermined x-radiation flux to an interior surface of a body cavity
JP2927966B2 (ja) * 1994-07-12 1999-07-28 フォトエレクトロン コーポレイション 体腔の内層表面に予め定められたフラックスを加えるためのｘ線装置
US5454782A (en) 1994-08-11 1995-10-03 Perkins; Rodney C. Translumenal circumferential energy delivery device
JP2802244B2 (ja) 1994-08-29 1998-09-24 オリンパス光学工業株式会社 内視鏡用シース
US5609151A (en) 1994-09-08 1997-03-11 Medtronic, Inc. Method for R-F ablation
US5524622A (en) 1994-09-20 1996-06-11 Oregon Health Sciences University Non-invasive method of determining inflammation of the gastrointestinal tract
US5558673A (en) 1994-09-30 1996-09-24 Vidamed, Inc. Medical probe device and method having a flexible resilient tape stylet
US5571116A (en) 1994-10-02 1996-11-05 United States Surgical Corporation Non-invasive treatment of gastroesophageal reflux disease
US6142994A (en) 1994-10-07 2000-11-07 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic a therapeutic element within the body
US5620044A (en) * 1994-10-07 1997-04-15 Ford Motor Company Gravity precision sand casting of aluminum and equivalent metals
US5514130A (en) * 1994-10-11 1996-05-07 Dorsal Med International RF apparatus for controlled depth ablation of soft tissue
US5588960A (en) 1994-12-01 1996-12-31 Vidamed, Inc. Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence
US5868740A (en) 1995-03-24 1999-02-09 Board Of Regents-Univ Of Nebraska Method for volumetric tissue ablation
CH688174A5 (fr) * 1995-03-28 1997-06-13 Norman Godin Prothèse pour s'opposer au reflux gastrique dans l'oesophage.
US5752522A (en) * 1995-05-04 1998-05-19 Cardiovascular Concepts, Inc. Lesion diameter measurement catheter and method
US5651788A (en) 1995-05-17 1997-07-29 C.R. Bard, Inc. Mucosectomy process and device
US5895355A (en) * 1995-05-23 1999-04-20 Cardima, Inc. Over-the-wire EP catheter
US6363937B1 (en) * 1995-06-07 2002-04-02 Arthrocare Corporation System and methods for electrosurgical treatment of the digestive system
US5709224A (en) 1995-06-07 1998-01-20 Radiotherapeutics Corporation Method and device for permanent vessel occlusion
US5702438A (en) 1995-06-08 1997-12-30 Avitall; Boaz Expandable recording and ablation catheter system
WO1997004702A1 (en) 1995-07-28 1997-02-13 Ep Technologies, Inc. Systems and methods for conducting electrophysiological testing using high-voltage energy pulses to stun heart tissue
US6023638A (en) * 1995-07-28 2000-02-08 Scimed Life Systems, Inc. System and method for conducting electrophysiological testing using high-voltage energy pulses to stun tissue
US5624439A (en) 1995-08-18 1997-04-29 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
KR19990064070A (ko) * 1995-10-06 1999-07-26 피터 이. 외팅거 체강내면의 엑스-선 조사장치
US5591195A (en) 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
US5823955A (en) 1995-11-20 1998-10-20 Medtronic Cardiorhythm Atrioventricular valve tissue ablation catheter and method
NL1001890C2 (nl) 1995-12-13 1997-06-17 Cordis Europ Catheter met plaatvormige elektrode-reeks.
US5766168A (en) * 1996-01-11 1998-06-16 Northgate Technologies, Inc. Perforated resectoscope electrode assembly
US5830213A (en) 1996-04-12 1998-11-03 Ep Technologies, Inc. Systems for heating and ablating tissue using multifunctional electrode structures
US5871483A (en) 1996-01-19 1999-02-16 Ep Technologies, Inc. Folding electrode structures
US5836874A (en) 1996-04-08 1998-11-17 Ep Technologies, Inc. Multi-function electrode structures for electrically analyzing and heating body tissue
US5925038A (en) 1996-01-19 1999-07-20 Ep Technologies, Inc. Expandable-collapsible electrode structures for capacitive coupling to tissue
US5904711A (en) * 1996-02-08 1999-05-18 Heartport, Inc. Expandable thoracoscopic defibrillation catheter system and method
CA2248260C (en) 1996-03-05 2010-11-16 Michael D. Laufer Vascular catheter-based system for heating tissue
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
US6152899A (en) 1996-03-05 2000-11-28 Vnus Medical Technologies, Inc. Expandable catheter having improved electrode design, and method for applying energy
US6033397A (en) * 1996-03-05 2000-03-07 Vnus Medical Technologies, Inc. Method and apparatus for treating esophageal varices
US5863291A (en) 1996-04-08 1999-01-26 Cardima, Inc. Linear ablation assembly
US5769880A (en) 1996-04-12 1998-06-23 Novacept Moisture transport system for contact electrocoagulation
US6013053A (en) 1996-05-17 2000-01-11 Qlt Photo Therapeutics Inc. Balloon catheter for photodynamic therapy
AU3204097A (en) 1996-05-22 1997-12-09 Somnus Medical Technologies, Inc. Method and apparatus for ablating turbinates
DE19626408A1 (de) 1996-07-01 1998-01-08 Berchtold Gmbh & Co Geb Trokar für laparoskopische Operationen
SE509241C2 (sv) 1996-07-18 1998-12-21 Radinvent Ab Anordningar för elektrodynamisk strålterapi av tumörsjukdomar
US5957920A (en) * 1997-08-28 1999-09-28 Isothermix, Inc. Medical instruments and techniques for treatment of urinary incontinence
US5820629A (en) 1996-08-13 1998-10-13 Medtronic, Inc. Intimal lining transition device and endarterectomy method
US6039701A (en) * 1996-09-05 2000-03-21 Ob Inovations, Inc. Method and apparatus for monitoring cervical diameter
EP0942765A1 (en) 1996-09-16 1999-09-22 Philip S. Green System and method for endosurgery employing conjoint operation of an endoscope and endosurgical instrument
US5891134A (en) * 1996-09-24 1999-04-06 Goble; Colin System and method for applying thermal energy to tissue
US6464697B1 (en) * 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US6016437A (en) * 1996-10-21 2000-01-18 Irvine Biomedical, Inc. Catheter probe system with inflatable soft shafts
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US6091995A (en) 1996-11-08 2000-07-18 Surx, Inc. Devices, methods, and systems for shrinking tissues
US6073052A (en) 1996-11-15 2000-06-06 Zelickson; Brian D. Device and method for treatment of gastroesophageal reflux disease
JP2001505100A (ja) 1996-11-21 2001-04-17 ボストン サイエンティフィック コーポレイション 光を利用した粘膜剥離
US5910104A (en) * 1996-12-26 1999-06-08 Cryogen, Inc. Cryosurgical probe with disposable sheath
US5916213A (en) * 1997-02-04 1999-06-29 Medtronic, Inc. Systems and methods for tissue mapping and ablation
US5938661A (en) * 1997-02-05 1999-08-17 Symbosis Corporation Single arm electrocautery probes for use with a resectoscope
US6338726B1 (en) * 1997-02-06 2002-01-15 Vidacare, Inc. Treating urinary and other body strictures
US5882329A (en) * 1997-02-12 1999-03-16 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
DE69823406T2 (de) 1997-02-21 2005-01-13 Medtronic AVE, Inc., Santa Rosa Röntgenvorrichtung versehen mit einer Dehnungsstruktur zur lokalen Bestrahlung des Inneren eines Körpers
US5833688A (en) 1997-02-24 1998-11-10 Boston Scientific Corporation Sensing temperature with plurality of catheter sensors
US6547787B1 (en) * 1997-03-13 2003-04-15 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6634363B1 (en) 1997-04-07 2003-10-21 Broncus Technologies, Inc. Methods of treating lungs having reversible obstructive pulmonary disease
US7425212B1 (en) 1998-06-10 2008-09-16 Asthmatx, Inc. Devices for modification of airways by transfer of energy
US5876340A (en) 1997-04-17 1999-03-02 Irvine Biomedical, Inc. Ablation apparatus with ultrasonic imaging capabilities
US6012457A (en) * 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
USH2037H1 (en) 1997-05-14 2002-07-02 David C. Yates Electrosurgical hemostatic device including an anvil
US6027499A (en) 1997-05-23 2000-02-22 Fiber-Tech Medical, Inc. (Assignee Of Jennifer B. Cartledge) Method and apparatus for cryogenic spray ablation of gastrointestinal mucosa
US6086583A (en) 1997-06-05 2000-07-11 Asahi Kogaku Kogyo Kabushiki Kaisha Electric cautery for endoscope
US5925040A (en) * 1997-06-18 1999-07-20 Medical Scientific, Inc. Electrosurgical instrument having a segmented roller electrode
JPH1120565A (ja) 1997-07-04 1999-01-26 Nissan Motor Co Ltd 車両用樹脂製装飾部品の取付構造
US6514249B1 (en) * 1997-07-08 2003-02-04 Atrionix, Inc. Positioning system and method for orienting an ablation element within a pulmonary vein ostium
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US5984861A (en) 1997-09-29 1999-11-16 Boston Scientific Corporation Endofluorescence imaging module for an endoscope
US6059719A (en) 1997-08-06 2000-05-09 Olympus Optical Co., Ltd. Endoscope system
JPH11221229A (ja) 1997-09-24 1999-08-17 Eclipse Surgical Technol Inc カテーテル
US6468272B1 (en) 1997-10-10 2002-10-22 Scimed Life Systems, Inc. Surgical probe for supporting diagnostic and therapeutic elements in contact with tissue in or around body orifices
US20030014052A1 (en) * 1997-11-14 2003-01-16 Buysse Steven P. Laparoscopic bipolar electrosurgical instrument
US6917834B2 (en) 1997-12-03 2005-07-12 Boston Scientific Scimed, Inc. Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
US6440128B1 (en) 1998-01-14 2002-08-27 Curon Medical, Inc. Actively cooled electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
AU2114299A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
AU2224499A (en) * 1998-01-14 1999-08-02 Curon Medical, Inc. Electrosurgical apparatus for treating gastroesophageal reflux disease (gerd) and method
AU2317899A (en) * 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Gerd treatment apparatus and method
US6423058B1 (en) 1998-02-19 2002-07-23 Curon Medical, Inc. Assemblies to visualize and treat sphincters and adjoining tissue regions
US7165551B2 (en) * 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6091993A (en) 1998-02-19 2000-07-18 American Medical Systems, Inc. Methods and apparatus for an electrode balloon
US7468060B2 (en) 1998-02-19 2008-12-23 Respiratory Diagnostic, Inc. Systems and methods for treating obesity and other gastrointestinal conditions
US7329254B2 (en) * 1998-02-19 2008-02-12 Curon Medical, Inc. Systems and methods for treating dysfunctions in the intestines and rectum that adapt to the anatomic form and structure of different individuals
US6402744B2 (en) * 1998-02-19 2002-06-11 Curon Medical, Inc. Systems and methods for forming composite lesions to treat dysfunction in sphincters and adjoining tissue regions
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6790207B2 (en) 1998-06-04 2004-09-14 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract
US6645201B1 (en) 1998-02-19 2003-11-11 Curon Medical, Inc. Systems and methods for treating dysfunctions in the intestines and rectum
US6355031B1 (en) * 1998-02-19 2002-03-12 Curon Medical, Inc. Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter
US6325798B1 (en) 1998-02-19 2001-12-04 Curon Medical, Inc. Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions
US6358245B1 (en) * 1998-02-19 2002-03-19 Curon Medical, Inc. Graphical user interface for association with an electrode structure deployed in contact with a tissue region
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US6860878B2 (en) * 1998-02-24 2005-03-01 Endovia Medical Inc. Interchangeable instrument
US20030135206A1 (en) 1998-02-27 2003-07-17 Curon Medical, Inc. Method for treating a sphincter
AU754424B2 (en) 1998-02-27 2002-11-14 Curon Medical, Inc. Apparatus to electrosurgically treat esophageal sphincters
US6169926B1 (en) 1998-02-27 2001-01-02 James A. Baker RF electrode array for low-rate collagen shrinkage in capsular shift procedures and methods of use
US6096054A (en) 1998-03-05 2000-08-01 Scimed Life Systems, Inc. Expandable atherectomy burr and method of ablating an occlusion from a patient's blood vessel
CA2320109A1 (en) 1998-03-06 1999-09-10 Curon Medical, Inc. Apparatus to electrosurgically treat esophageal sphincters
US20030109837A1 (en) 1998-03-13 2003-06-12 Mcbride-Sakal Marcia Brush to clear occluded stents
US6146149A (en) 1998-03-30 2000-11-14 Lucent Technologies Inc Building entrance protector with replaceable fusible link assembly
US6325800B1 (en) 1998-04-15 2001-12-04 Boston Scientific Corporation Electro-cautery catheter
US6432104B1 (en) 1998-04-15 2002-08-13 Scimed Life Systems, Inc. Electro-cautery catherer
WO1999055245A1 (en) 1998-04-30 1999-11-04 Edwards Stuart D Electrosurgical sphincter treatment apparatus
US6004262A (en) 1998-05-04 1999-12-21 Ad-Tech Medical Instrument Corp. Visually-positioned electrical monitoring apparatus
US6740082B2 (en) 1998-12-29 2004-05-25 John H. Shadduck Surgical instruments for treating gastro-esophageal reflux
US6837885B2 (en) 1998-05-22 2005-01-04 Scimed Life Systems, Inc. Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifices and within tumors
US6802841B2 (en) * 1998-06-04 2004-10-12 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
US5997534A (en) 1998-06-08 1999-12-07 Tu; Hosheng Medical ablation device and methods thereof
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
JP3919947B2 (ja) * 1998-07-09 2007-05-30 アルフレッサファーマ株式会社 マイクロ波手術用電極装置
US6296639B1 (en) 1999-02-12 2001-10-02 Novacept Apparatuses and methods for interstitial tissue removal
US6112123A (en) 1998-07-28 2000-08-29 Endonetics, Inc. Device and method for ablation of tissue
US6572639B1 (en) 1998-07-31 2003-06-03 Surx, Inc. Interspersed heating/cooling to shrink tissues for incontinence
US6053913A (en) * 1998-09-10 2000-04-25 Tu; Lily Chen Rapid exchange stented balloon catheter having ablation capabilities
US6183468B1 (en) * 1998-09-10 2001-02-06 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6245065B1 (en) 1998-09-10 2001-06-12 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6123703A (en) 1998-09-19 2000-09-26 Tu; Lily Chen Ablation catheter and methods for treating tissues
WO2000019926A1 (en) 1998-10-05 2000-04-13 Scimed Life Systems, Inc. Large area thermal ablation
WO2000024331A1 (en) * 1998-10-23 2000-05-04 Sherwood Services Ag Endoscopic bipolar electrosurgical forceps
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6258118B1 (en) 1998-11-25 2001-07-10 Israel Aircraft Industries Ltd. Removable support device
US6102908A (en) 1999-01-04 2000-08-15 Tu; Lily Chen Rotatable apparatus having ablation capabilities
US20030171747A1 (en) * 1999-01-25 2003-09-11 Olympus Optical Co., Ltd. Medical treatment instrument
US6409723B1 (en) 1999-04-02 2002-06-25 Stuart D. Edwards Treating body tissue by applying energy and substances
US6425877B1 (en) 1999-04-02 2002-07-30 Novasys Medical, Inc. Treatment of tissue in the digestive circulatory respiratory urinary and reproductive systems
US6162237A (en) 1999-04-19 2000-12-19 Chan; Winston Kam Yew Temporary intravascular stent for use in retrohepatic IVC or hepatic vein injury
US6149647A (en) 1999-04-19 2000-11-21 Tu; Lily Chen Apparatus and methods for tissue treatment
US6138046A (en) 1999-04-20 2000-10-24 Miravant Medical Technologies, Inc. Dosimetry probe
WO2000066017A1 (en) 1999-05-04 2000-11-09 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
AU5275600A (en) 1999-05-18 2000-12-05 Silhouette Medical Inc. Surgical weight control device
US6237355B1 (en) 1999-06-25 2001-05-29 Cryogen, Inc. Precooled cryogenic ablation system
US7160312B2 (en) 1999-06-25 2007-01-09 Usgi Medical, Inc. Implantable artificial partition and methods of use
US6238392B1 (en) 1999-06-29 2001-05-29 Ethicon Endo-Surgery, Inc. Bipolar electrosurgical instrument including a plurality of balloon electrodes
US6358197B1 (en) * 1999-08-13 2002-03-19 Enteric Medical Technologies, Inc. Apparatus for forming implants in gastrointestinal tract and kit for use therewith
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
EP1210024A1 (en) * 1999-09-08 2002-06-05 Curon Medical, Inc. System for controlling a family of treatment devices
WO2001017453A2 (en) 1999-09-08 2001-03-15 Curon Medical, Inc. Systems and methods for monitoring and controlling use of medical devices
WO2001018616A2 (en) * 1999-09-08 2001-03-15 Curon Medical, Inc. System for controlling use of medical devices
EP1244392A1 (en) 1999-09-28 2002-10-02 Novasys Medical, Inc. Treatment of tissue by application of energy and drugs
JP2001120565A (ja) 1999-10-22 2001-05-08 Olympus Optical Co Ltd 高周波処置具
US20060095032A1 (en) 1999-11-16 2006-05-04 Jerome Jackson Methods and systems for determining physiologic characteristics for treatment of the esophagus
WO2001035846A1 (en) 1999-11-16 2001-05-25 Ganz Robert A System and method of treating abnormal tissue in the human esophagus
US20040215296A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. System and method for treating abnormal epithelium in an esophagus
US20040215235A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. Methods and systems for determining physiologic characteristics for treatment of the esophagus
US6542781B1 (en) * 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
AU2598201A (en) 1999-12-23 2001-07-03 Therus Corporation Ultrasound transducers for imaging and therapy
US6547776B1 (en) * 2000-01-03 2003-04-15 Curon Medical, Inc. Systems and methods for treating tissue in the crura
US6689131B2 (en) 2001-03-08 2004-02-10 Tissuelink Medical, Inc. Electrosurgical device having a tissue reduction sensor
US6544226B1 (en) * 2000-03-13 2003-04-08 Curon Medical, Inc. Operative devices that can be removably fitted on catheter bodies to treat tissue regions in the body
US6837886B2 (en) 2000-05-03 2005-01-04 C.R. Bard, Inc. Apparatus and methods for mapping and ablation in electrophysiology procedures
AU2001263221A1 (en) 2000-05-16 2001-11-26 Atrionix, Inc. Deflectable tip catheter with guidewire tracking mechanism
US6743239B1 (en) * 2000-05-25 2004-06-01 St. Jude Medical, Inc. Devices with a bendable tip for medical procedures
JP2001358214A (ja) 2000-06-15 2001-12-26 Mitsubishi Electric Corp 半導体装置および半導体装置の製造方法
US6454790B1 (en) 2000-07-21 2002-09-24 Ceramoptec Industries, Inc. Treatment for Barrett's syndrome
US7678106B2 (en) 2000-08-09 2010-03-16 Halt Medical, Inc. Gynecological ablation procedure and system
US6572578B1 (en) 2000-08-25 2003-06-03 Patrick A. Blanchard Fluid-jet catheter and its application to flexible endoscopy
US20040087936A1 (en) 2000-11-16 2004-05-06 Barrx, Inc. System and method for treating abnormal tissue in an organ having a layered tissue structure
ATE378014T1 (de) 2000-11-16 2007-11-15 Barrx Medical Inc System zum behandeln von abnormalem gewebe in der menschlichen speiseröhre
US6551315B2 (en) * 2000-12-06 2003-04-22 Syntheon, Llc Methods and apparatus for the treatment of gastric ulcers
US20020087151A1 (en) 2000-12-29 2002-07-04 Afx, Inc. Tissue ablation apparatus with a sliding ablation instrument and method
US6415016B1 (en) 2001-01-09 2002-07-02 Medtronic Ave, Inc. Crystal quartz insulating shell for X-ray catheter
US6712815B2 (en) * 2001-01-16 2004-03-30 Novacept, Inc. Apparatus and method for treating venous reflux
US6699243B2 (en) * 2001-09-19 2004-03-02 Curon Medical, Inc. Devices, systems and methods for treating tissue regions of the body
US20030181900A1 (en) 2002-03-25 2003-09-25 Long Gary L. Endoscopic ablation system with a plurality of electrodes
US6918906B2 (en) 2001-03-30 2005-07-19 Gary L. Long Endoscopic ablation system with improved electrode geometry
US7097644B2 (en) 2001-03-30 2006-08-29 Ethicon Endo-Surgery, Inc. Medical device with improved wall construction
US20020177847A1 (en) 2001-03-30 2002-11-28 Long Gary L. Endoscopic ablation system with flexible coupling
US7101373B2 (en) * 2001-04-06 2006-09-05 Sherwood Services Ag Vessel sealer and divider
US6800083B2 (en) 2001-04-09 2004-10-05 Scimed Life Systems, Inc. Compressible atherectomy burr
US7083629B2 (en) 2001-05-30 2006-08-01 Satiety, Inc. Overtube apparatus for insertion into a body
US6558400B2 (en) 2001-05-30 2003-05-06 Satiety, Inc. Obesity treatment tools and methods
JP3722729B2 (ja) 2001-06-04 2005-11-30 オリンパス株式会社 内視鏡用処置装置
US6572610B2 (en) 2001-08-21 2003-06-03 Cryogen, Inc. Cryogenic catheter with deflectable tip
US6953469B2 (en) 2001-08-30 2005-10-11 Ethicon, Inc, Device and method for treating intraluminal tissue
US20060155261A1 (en) 2001-09-19 2006-07-13 Curon Medical, Inc. Systems and methods for treating tissue regions of the body
US7615049B2 (en) 2001-09-19 2009-11-10 Mederi Therapeutics, Inc. Devices, systems and methods for treating tissue regions of the body
US6652518B2 (en) * 2001-09-28 2003-11-25 Ethicon, Inc. Transmural ablation tool and method
CA2468531C (en) * 2001-11-29 2010-06-01 Medwaves, Inc. Radio-frequency-based catheter system with improved deflection and steering mechanisms
US6641581B2 (en) * 2001-12-11 2003-11-04 Mohiuddin M. Muzzammel Variable angle cervical excision electrode
ATE526883T1 (de) 2001-12-27 2011-10-15 Olympus Corp UMMANTELUNG MIT GERÄTEN FÜR DAS ENDOSKOPISCHE GEWINNEN VON BLUTGEFÄßEN
US20030153905A1 (en) 2002-01-25 2003-08-14 Edwards Stuart Denzil Selective ablation system
US7479120B2 (en) 2002-02-22 2009-01-20 Hans Gregersen Method and apparatus for investigating force-deformation properties in muscles in walls of bodily hollow systems
US7137981B2 (en) 2002-03-25 2006-11-21 Ethicon Endo-Surgery, Inc. Endoscopic ablation system with a distally mounted image sensor
US6855140B2 (en) * 2002-06-06 2005-02-15 Thomas E. Albrecht Method of tissue lesion removal
US6929642B2 (en) 2002-06-28 2005-08-16 Ethicon, Inc. RF device for treating the uterus
US7004940B2 (en) * 2002-10-10 2006-02-28 Ethicon, Inc. Devices for performing thermal ablation having movable ultrasound transducers
US7083620B2 (en) * 2002-10-30 2006-08-01 Medtronic, Inc. Electrosurgical hemostat
US8066700B2 (en) * 2003-01-31 2011-11-29 Smith & Nephew, Inc. Cartilage treatment probe
DE602004012232T2 (de) 2003-01-31 2009-03-12 Smith & Nephew, Inc., Andover Knorpelbehandlungssonde
US7744583B2 (en) 2003-02-03 2010-06-29 Boston Scientific Scimed Systems and methods of de-endothelialization
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
US6860787B1 (en) * 2003-03-31 2005-03-01 Hasbro, Inc. Toy having a simulated climbing figure
US6964661B2 (en) 2003-04-02 2005-11-15 Boston Scientific Scimed, Inc. Endovenous ablation mechanism with feedback control
US20040215180A1 (en) 2003-04-25 2004-10-28 Medtronic, Inc. Ablation of stomach lining to treat obesity
US7090637B2 (en) 2003-05-23 2006-08-15 Novare Surgical Systems, Inc. Articulating mechanism for remote manipulation of a surgical or diagnostic tool
EP1635726A2 (en) 2003-05-27 2006-03-22 Venture Manufacturing LLC Balloon centered radially expanding ablation device
US7160294B2 (en) * 2003-09-02 2007-01-09 Curon Medical, Inc. Systems and methods for treating hemorrhoids
JP4441227B2 (ja) * 2003-10-08 2010-03-31 Ｈｏｙａ株式会社 高周波処置用内視鏡
US7416549B2 (en) 2003-10-10 2008-08-26 Boston Scientific Scimed, Inc. Multi-zone bipolar ablation probe assembly
US20050090817A1 (en) * 2003-10-22 2005-04-28 Scimed Life Systems, Inc. Bendable endoscopic bipolar device
US7252665B2 (en) 2003-10-31 2007-08-07 Medtronic, Inc Ablation of stomach lining to reduce stomach acid secretion
US7351201B2 (en) * 2003-12-19 2008-04-01 Pentax Corporation Treatment instrument for endoscope
US7150745B2 (en) * 2004-01-09 2006-12-19 Barrx Medical, Inc. Devices and methods for treatment of luminal tissue
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US20050288664A1 (en) 2004-06-21 2005-12-29 Curon Medical, Inc. Systems and methods for treating tissue regions of the body
US20060020276A1 (en) 2004-07-23 2006-01-26 Usgi Medical Inc. Apparatus and methods for achieving prolonged maintenance of gastrointestinal tissue folds
US20060069303A1 (en) * 2004-09-30 2006-03-30 Couvillon Lucien A Jr Endoscopic apparatus with integrated hemostasis device
US7674260B2 (en) 2005-04-28 2010-03-09 Cytyc Corporation Emergency hemostasis device utilizing energy
JP2009500052A (ja) 2005-06-20 2009-01-08 アブレーション フロンティアズ，インコーポレーテッド アブレーションカテーテル
ES2381560T3 (es) 2005-09-30 2012-05-29 Covidien Ag Funda aislante para fórceps electroquirúrgicos
US7325800B2 (en) 2005-10-26 2008-02-05 Xerox Corporation Sloped stack detection sensor and algorithm
US7959627B2 (en) 2005-11-23 2011-06-14 Barrx Medical, Inc. Precision ablating device
US7997278B2 (en) 2005-11-23 2011-08-16 Barrx Medical, Inc. Precision ablating method
US8702694B2 (en) 2005-11-23 2014-04-22 Covidien Lp Auto-aligning ablating device and method of use
BRPI0618981A2 (pt) 2005-11-23 2011-09-20 Barrx Medical Inc dispositivo de ablação
US8641711B2 (en) 2007-05-04 2014-02-04 Covidien Lp Method and apparatus for gastrointestinal tract ablation for treatment of obesity
US8784338B2 (en) 2007-06-22 2014-07-22 Covidien Lp Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size
EP2170202A1 (en) * 2007-07-06 2010-04-07 Barrx Medical, Inc. Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding
US8251992B2 (en) * 2007-07-06 2012-08-28 Tyco Healthcare Group Lp Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation
US20090012518A1 (en) * 2007-07-06 2009-01-08 Utley David S Method and Apparatus for Ablation of Benign, Pre-Cancerous and Early Cancerous Lesions That Originate Within the Epithelium and are Limited to the Mucosal Layer of the Gastrointestinal Tract
US8646460B2 (en) 2007-07-30 2014-02-11 Covidien Lp Cleaning device and methods
US8273012B2 (en) 2007-07-30 2012-09-25 Tyco Healthcare Group, Lp Cleaning device and methods
US20090318914A1 (en) 2008-06-18 2009-12-24 Utley David S System and method for ablational treatment of uterine cervical neoplasia
JP2011020565A (ja) 2009-07-16 2011-02-03 Shoyoseiki Co Ltd ボールトランスファ
US10278774B2 (en) 2011-03-18 2019-05-07 Covidien Lp Selectively expandable operative element support structure and methods of use

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11944376B2 (en) 2006-03-24 2024-04-02 Neuwave Medical, Inc. Transmission line with heat transfer ability
US10363092B2 (en) 2006-03-24 2019-07-30 Neuwave Medical, Inc. Transmission line with heat transfer ability
US11596474B2 (en) 2006-07-14 2023-03-07 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11576723B2 (en) 2006-07-14 2023-02-14 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11576722B2 (en) 2006-07-14 2023-02-14 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11389235B2 (en) 2006-07-14 2022-07-19 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US10376314B2 (en) 2006-07-14 2019-08-13 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11013557B2 (en) 2009-07-28 2021-05-25 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US9877783B2 (en) 2009-07-28 2018-01-30 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US10357312B2 (en) 2009-07-28 2019-07-23 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11490960B2 (en) 2010-05-03 2022-11-08 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US9872729B2 (en) 2010-05-03 2018-01-23 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US10603106B2 (en) 2010-05-03 2020-03-31 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US9861440B2 (en) 2010-05-03 2018-01-09 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US10524862B2 (en) 2010-05-03 2020-01-07 Neuwave Medical, Inc. Energy delivery systems and uses thereof
CN103200890A (zh) * 2010-10-29 2013-07-10 麦德托尼克消融前沿有限公司 低温射频消融系统
US10667860B2 (en) 2011-12-21 2020-06-02 Neuwave Medical, Inc. Energy delivery systems and uses thereof
CN104220020B (zh) * 2011-12-21 2017-08-08 纽华沃医药公司 一种消融天线装置
US11638607B2 (en) 2011-12-21 2023-05-02 Neuwave Medical, Inc. Energy delivery systems and uses thereof
CN104220020A (zh) * 2011-12-21 2014-12-17 纽华沃医药公司 能量输送系统及其用途
US10952792B2 (en) 2015-10-26 2021-03-23 Neuwave Medical, Inc. Energy delivery systems and uses thereof
US11678935B2 (en) 2015-10-26 2023-06-20 Neuwave Medical, Inc. Energy delivery systems and uses thereof
CN108882957A (zh) * 2016-02-10 2018-11-23 埃米尔·丹尼尔·贝尔森 个性化的心房颤动消融
US11395699B2 (en) 2016-04-15 2022-07-26 Neuwave Medical, Inc. Systems and methods for energy delivery
US10531917B2 (en) 2016-04-15 2020-01-14 Neuwave Medical, Inc. Systems and methods for energy delivery
US11672596B2 (en) 2018-02-26 2023-06-13 Neuwave Medical, Inc. Energy delivery devices with flexible and adjustable tips
US11832879B2 (en) 2019-03-08 2023-12-05 Neuwave Medical, Inc. Systems and methods for energy delivery

Also Published As

Publication number Publication date
BRPI0620168A2 (pt) 2011-11-01
EP2604214B1 (en) 2014-08-13
EP2604214A1 (en) 2013-06-19
WO2007097805A3 (en) 2008-10-30
HK1122203A1 (zh) 2009-05-15
JP5675745B2 (ja) 2015-02-25
JP5227183B2 (ja) 2013-07-03
EP1968471A4 (en) 2010-07-28
KR20080091149A (ko) 2008-10-09
AU2006338555A1 (en) 2007-08-30
JP2013048909A (ja) 2013-03-14
WO2007097805A2 (en) 2007-08-30
EP1968471A2 (en) 2008-09-17
US20140243817A1 (en) 2014-08-28
CA2633687A1 (en) 2007-08-30
BRPI0620168B1 (pt) 2018-12-04
EP1968471B1 (en) 2016-03-23
JP2009520572A (ja) 2009-05-28
US9918793B2 (en) 2018-03-20
KR101334890B1 (ko) 2013-12-02
AU2006338555B2 (en) 2013-01-10
MX2008008123A (es) 2008-09-08
BRPI0620168B8 (pt) 2021-06-22
US20070118104A1 (en) 2007-05-24
US20140243818A1 (en) 2014-08-28
US20090177194A1 (en) 2009-07-09
US8702694B2 (en) 2014-04-22
US8702695B2 (en) 2014-04-22
CN101563042B (zh) 2011-07-13
US9918794B2 (en) 2018-03-20
CA2633687C (en) 2016-03-22

Similar Documents

Publication Publication Date Title
CN101563042B (zh) 自动对准的消融装置及其使用方法
CN101355913B (zh) 精确消融器械
US9993281B2 (en) Method and apparatus for gastrointestinal tract ablation for treatment of obesity
US7997278B2 (en) Precision ablating method
AU2006318617B2 (en) Precision ablating device
TW200911316A (en) Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation
AU2013202904B2 (en) Auto-Aligning Ablating Device and Method of Use
AU2012238192B2 (en) Precision ablating device

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: TYCO HEALTHCARE GROUP LP

Free format text: FORMER OWNER: BARRX MEDICAL INC.

Effective date: 20130606

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: COVIDIEN LIMITED PARTNERSHIP

Free format text: FORMER NAME: TYCO HEALTHCARE GROUP LP

CP01 Change in the name or title of a patent holder

Address after: Massachusetts, USA

Patentee after: COVIDIEN L.P.

Address before: Massachusetts, USA

Patentee before: VNUS MEDICAL TECHNOLOGIES, Inc.

Address after: California, USA

Patentee after: Balkis medicine LLC

Address before: California, USA

Patentee before: BARRX MEDICAL, Inc.

TR01 Transfer of patent right

Effective date of registration: 20130606

Address after: Massachusetts, USA

Patentee after: VNUS MEDICAL TECHNOLOGIES, Inc.

Address before: California, USA

Patentee before: Balkis medicine LLC