CN101512384A - 检测和确认分析物的磁共振系统和方法 - Google Patents
检测和确认分析物的磁共振系统和方法 Download PDFInfo
- Publication number
- CN101512384A CN101512384A CNA2006800188550A CN200680018855A CN101512384A CN 101512384 A CN101512384 A CN 101512384A CN A2006800188550 A CNA2006800188550 A CN A2006800188550A CN 200680018855 A CN200680018855 A CN 200680018855A CN 101512384 A CN101512384 A CN 101512384A
- Authority
- CN
- China
- Prior art keywords
- liquid
- analyte
- magnetic field
- sample
- magnetic resonance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
- G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
- G01R33/34053—Solenoid coils; Toroidal coils
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
- G01R33/3806—Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
- G01R33/383—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using permanent magnets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
- G01N24/084—Detection of potentially hazardous samples, e.g. toxic samples, explosives, drugs, firearms, weapons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/81—Of specified metal or metal alloy composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/92—Detection of biochemical
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- High Energy & Nuclear Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (42)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66901905P | 2005-04-07 | 2005-04-07 | |
US60/669,019 | 2005-04-07 | ||
US67338205P | 2005-04-21 | 2005-04-21 | |
US60/673,382 | 2005-04-21 | ||
US11/335,995 | 2006-01-20 | ||
US11/335,995 US7781228B2 (en) | 2005-04-07 | 2006-01-20 | Magnetic resonance system and method to detect and confirm analytes |
PCT/US2006/002368 WO2007086840A2 (en) | 2005-04-07 | 2006-01-24 | A magnetic resonance system and method to detect and confirm analytes |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101512384A true CN101512384A (zh) | 2009-08-19 |
CN101512384B CN101512384B (zh) | 2012-05-30 |
Family
ID=37679525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800188550A Expired - Fee Related CN101512384B (zh) | 2005-04-07 | 2006-01-24 | 检测和确认分析物的磁共振系统和方法 |
Country Status (8)
Country | Link |
---|---|
US (2) | US7781228B2 (zh) |
EP (1) | EP1869466B1 (zh) |
JP (1) | JP5289939B2 (zh) |
CN (1) | CN101512384B (zh) |
CA (1) | CA2604150C (zh) |
ES (1) | ES2495718T3 (zh) |
HK (1) | HK1132552A1 (zh) |
WO (1) | WO2007086840A2 (zh) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103217530A (zh) * | 2013-03-26 | 2013-07-24 | 南昌大学 | 一种基于顺磁纳米Fe-Co合金探针间接富集的NMR食源性致病菌快速检测方法 |
CN103760186A (zh) * | 2012-09-13 | 2014-04-30 | 阿斯派克影像有限公司 | 用于体外诊断应用的使用顺磁剂的工具和方法 |
CN104487830A (zh) * | 2012-07-02 | 2015-04-01 | 米利开尔文科技有限公司 | 用于磁共振的改良技术、系统和机器可读程序 |
CN106459896A (zh) * | 2014-02-26 | 2017-02-22 | 布里格姆女子医院有限公司 | 用于磁性自组装的系统和方法 |
CN106645395A (zh) * | 2016-12-07 | 2017-05-10 | 中国人民解放军军械工程学院 | 基于同轴测试装置的场敏感型电磁脉冲防护材料测试系统 |
CN107110939A (zh) * | 2014-09-11 | 2017-08-29 | 力保科学公司 | 使用包括hdl和炎症生物标志相互作用参数的风险参数的心血管风险评估 |
CN108693491A (zh) * | 2017-04-07 | 2018-10-23 | 康奈尔大学 | 稳健的定量磁化率成像系统和方法 |
CN111627645A (zh) * | 2020-06-01 | 2020-09-04 | 北京卫星环境工程研究所 | 利用Halbach永磁阵列减小铁磁性材料磁性的方法 |
CN111975805A (zh) * | 2020-08-31 | 2020-11-24 | 哈尔滨工业大学(深圳) | 一种驱动磁性微纳米机器人的磁场操控系统 |
CN112804938A (zh) * | 2018-08-08 | 2021-05-14 | 布赖特斯佩克股份有限公司 | 用于低挥发性采样的方法和设备 |
CN114910838A (zh) * | 2021-02-10 | 2022-08-16 | 清华大学 | 磁场增强组件以及磁场增强器件 |
CN114910838B (zh) * | 2021-02-10 | 2024-04-26 | 清华大学 | 磁场增强组件以及磁场增强器件 |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5295769B2 (ja) * | 2005-08-31 | 2013-09-18 | ティツー・バイオシステムズ・インコーポレーテッド | 分析物を検出するためのnmr装置 |
US20070166730A1 (en) * | 2006-01-19 | 2007-07-19 | Menon & Associates, Inc. | Magnetic resonance system and method to detect and confirm analytes |
US8644396B2 (en) * | 2006-04-18 | 2014-02-04 | Qualcomm Incorporated | Waveform encoding for wireless applications |
AU2007317787B2 (en) * | 2006-11-08 | 2012-07-12 | T2 Biosystems, Inc. | NMR systems for in vivo detection of analytes |
US7972787B2 (en) * | 2007-02-16 | 2011-07-05 | Massachusetts Eye And Ear Infirmary | Methods for detecting age-related macular degeneration |
US8114683B2 (en) * | 2007-03-05 | 2012-02-14 | Headway Technologies, Inc. | Low temperature method to enhance detection of magnetic beads |
WO2008109126A1 (en) * | 2007-03-06 | 2008-09-12 | Harvard University Otd (Office Of Technology Development) | Permanent magnet system |
US7994786B2 (en) * | 2007-06-19 | 2011-08-09 | Mary Hitchcock Memorial Hospital | System and method for use of nanoparticles in imaging and temperature measurement |
US8409463B1 (en) | 2007-07-16 | 2013-04-02 | University Of Central Florida Research Foundation, Inc. | Aqueous method for making magnetic iron oxide nanoparticles |
US20110070657A1 (en) * | 2007-08-17 | 2011-03-24 | The General Hospital Corporation | Detecting ions and measuring ion concentrations |
CA2700970A1 (en) * | 2007-09-28 | 2009-04-09 | T2 Biosystems, Inc. | Nmr diagnostics by means of a plastic sample container |
US8519708B2 (en) * | 2007-11-06 | 2013-08-27 | T2 Biosystems, Inc. | Small magnet and RF coil for magnetic resonance relaxometry |
US9157974B2 (en) | 2008-10-29 | 2015-10-13 | T2 Biosystems, Inc. | NMR detection of coagulation time |
GB0820688D0 (en) * | 2008-11-12 | 2008-12-17 | Siemens Ag | Resolution improvement |
GB0820687D0 (en) * | 2008-11-12 | 2008-12-17 | Siemens Ag | Upconversion method |
US8154285B1 (en) | 2009-05-29 | 2012-04-10 | The Invention Science Fund I, Llc | Non-external static magnetic field imaging systems, devices, methods, and compositions |
US8058872B2 (en) | 2009-05-29 | 2011-11-15 | The Invention Science Fund I, Llc | Systems, devices, methods, and compositions including functionalized ferromagnetic structures |
US8106655B2 (en) * | 2009-05-29 | 2012-01-31 | The Invention Science Fund I, Llc | Multiplex imaging systems, devices, methods, and compositions including ferromagnetic structures |
US8063636B2 (en) * | 2009-05-29 | 2011-11-22 | The Invention Science Fund I, Llc | Systems, devices, methods, and compositions including targeted ferromagnetic structures |
US20100303733A1 (en) * | 2009-05-29 | 2010-12-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, methods, and compositions including ferromagnetic structures |
US8193808B2 (en) * | 2009-09-11 | 2012-06-05 | Hewlett-Packard Development Company, L.P. | Optically integrated biosensor based on optically detected magnetic resonance |
US8565892B2 (en) * | 2009-10-31 | 2013-10-22 | Qteris, Inc. | Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment |
US10876964B2 (en) * | 2009-12-18 | 2020-12-29 | Koninklijke Philips N.V. | System, apparatus and method for determining a substance within a fluid |
US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
US8401600B1 (en) | 2010-08-02 | 2013-03-19 | Hypres, Inc. | Superconducting multi-bit digital mixer |
US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
CN103384724B (zh) | 2010-10-22 | 2017-11-17 | T2生物系统公司 | 用于检测分析物的核磁共振系统和方法 |
CN102096111B (zh) * | 2010-12-07 | 2012-10-10 | 吉林大学 | 收发天线分离式核磁共振找水装置及找水方法 |
EP2732046B1 (en) | 2011-07-13 | 2017-09-06 | T2 Biosystems, Inc. | Nmr methods for monitoring blood clot formation |
KR20130015634A (ko) * | 2011-08-04 | 2013-02-14 | 삼성전자주식회사 | 자성 나노입자의 응집을 이용한 바이오센서 및 그의 검출 방법 |
US10620205B2 (en) | 2011-09-21 | 2020-04-14 | T2 Biosystems, Inc. | NMR methods for endotoxin analysis |
WO2013049457A1 (en) * | 2011-09-30 | 2013-04-04 | General Electric Company | Micro-magnetic resonance system and method for managing anlaysis data |
US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
WO2015171773A1 (en) * | 2014-05-07 | 2015-11-12 | The Trustees Of Dartmouth College | Method and apparatus for nonlinear susceptibility magnitude imaging of magnetic nanoparticles |
CA2893591A1 (en) | 2012-12-07 | 2014-06-12 | T2 Biosystems, Inc. | Methods for monitoring tight clot formation |
WO2014095645A1 (en) | 2012-12-17 | 2014-06-26 | General Electric Company | In-vitro magnetic resonance detection of a target substance |
US9772386B2 (en) | 2013-03-15 | 2017-09-26 | Fresenius Medical Care Holdings, Inc. | Dialysis system with sample concentration determination device using magnet and radio frequency coil assemblies |
US9713664B2 (en) | 2013-03-15 | 2017-07-25 | Fresenius Medical Care Holdings, Inc. | Nuclear magnetic resonance module for a dialysis machine |
US9597439B2 (en) | 2013-03-15 | 2017-03-21 | Fresenius Medical Care Holdings, Inc. | Medical fluid sensing and concentration determination using radio frequency energy and a magnetic field |
US9433718B2 (en) * | 2013-03-15 | 2016-09-06 | Fresenius Medical Care Holdings, Inc. | Medical fluid system including radio frequency (RF) device within a magnetic assembly, and fluid cartridge body with one of multiple passageways disposed within the RF device, and specially configured cartridge gap accepting a portion of said RF device |
US9566377B2 (en) | 2013-03-15 | 2017-02-14 | Fresenius Medical Care Holdings, Inc. | Medical fluid sensing and concentration determination in a fluid cartridge with multiple passageways, using a radio frequency device situated within a magnetic field |
US9482643B2 (en) * | 2013-11-26 | 2016-11-01 | Aspect Imaging Ltd. | Means and methods using paramagnetic agents for in vitro diagnostic applications |
US10286135B2 (en) | 2014-03-28 | 2019-05-14 | Fresenius Medical Care Holdings, Inc. | Measuring conductivity of a medical fluid |
CN104155325B (zh) * | 2014-07-09 | 2017-01-11 | 上海美吉医学检验有限公司 | 一种基于磁性微珠的样品无转移低场nmr稀有细胞快速检测方法 |
CN104297279B (zh) * | 2014-10-15 | 2016-08-17 | 东华大学 | 一种利用γ-聚谷氨酸稳定的四氧化三铁纳米颗粒检测三价铬离子的方法 |
CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
CN109425907B (zh) * | 2017-08-28 | 2020-08-28 | 中国科学院电子学研究所 | 一种频率域磁异常化极的方法 |
EP3750516A1 (en) * | 2019-06-13 | 2020-12-16 | SD Sensitive Diaper GmbH | Detecting device for detecting a state of a diaper, diaper accommodating the detecting device |
CN110530565B (zh) * | 2019-09-23 | 2021-04-13 | 中国工程物理研究院流体物理研究所 | 一种基于光纤探针的多路时间测量装置和方法 |
WO2021195055A1 (en) * | 2020-03-23 | 2021-09-30 | AMI Research & Development, LLC | Low power stimulated emissions nmr using rabi transitions for the detection of molecules |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
GB8401368D0 (en) | 1984-01-19 | 1984-02-22 | Amersham Int Plc | Assay method |
US5073858A (en) | 1984-12-10 | 1991-12-17 | Mills Randell L | Magnetic susceptibility imaging (msi) |
US5076950A (en) | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
US4875486A (en) | 1986-09-04 | 1989-10-24 | Advanced Techtronics, Inc. | Instrument and method for non-invasive in vivo testing for body fluid constituents |
US5108933A (en) | 1988-09-16 | 1992-04-28 | Immunicon Corporation | Manipulation of colloids for facilitating magnetic separations |
US4994746A (en) * | 1989-09-05 | 1991-02-19 | Advanced Techtronics, Inc. | Method of and apparatus for nuclear magnetic resonance analysis using true logarithmic amplifier |
US5254460A (en) | 1990-05-03 | 1993-10-19 | Advanced Magnetics, Inc. | Solvent mediated relaxation assay system |
US5445970A (en) | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
US5445971A (en) | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
FR2710410B1 (fr) | 1993-09-20 | 1995-10-20 | Bio Merieux | Procédé et dispositif pour la détermination d'un analyte dans un échantillon . |
FI944939A0 (fi) | 1994-10-20 | 1994-10-20 | Labsystems Oy | Foerfarande foer separering av partiklar |
US6500343B2 (en) | 1995-02-21 | 2002-12-31 | Iqbal W. Siddiqi | Method for mixing and separation employing magnetic particles |
FR2732116B1 (fr) | 1995-03-21 | 1997-05-09 | Bio Merieux | Procede et dispositif pour la determination qualitative et/ou quantitative d'un analyte, notamment d'une bacterie, dans un echantillon, par voie magnetique |
US6012188A (en) * | 1996-03-13 | 2000-01-11 | Ooltewah Manufacturing Company | Selectively deformable cushion |
FR2748569B1 (fr) | 1996-05-07 | 1998-08-07 | Biocom Sa | Procede et installation de separation de particules magnetiques dans un fluide pour l'analyse biologique, et application dudit procede |
US6143578A (en) | 1996-05-10 | 2000-11-07 | Bayer Corporation | Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology |
US5993665A (en) | 1996-06-07 | 1999-11-30 | Immunivest Corporation | Quantitative cell analysis methods employing magnetic separation |
FR2758884B1 (fr) | 1997-01-30 | 1999-04-02 | Bio Merieux | Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu |
US5981297A (en) | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
US5998224A (en) | 1997-05-16 | 1999-12-07 | Abbott Laboratories | Magnetically assisted binding assays utilizing a magnetically responsive reagent |
US6159378A (en) | 1999-02-23 | 2000-12-12 | Battelle Memorial Institute | Apparatus and method for handling magnetic particles in a fluid |
US6511967B1 (en) * | 1999-04-23 | 2003-01-28 | The General Hospital Corporation | Use of an internalizing transferrin receptor to image transgene expression |
US6852493B2 (en) | 1999-05-14 | 2005-02-08 | Iris Biotechnologies, Inc. | Magnetic field enhanced hybridization of target molecules to immobilized probes |
US6623982B1 (en) | 1999-07-12 | 2003-09-23 | Immunivest Corporation | Increased separation efficiency via controlled aggregation of magnetic nanoparticles |
WO2001011360A2 (de) | 1999-08-06 | 2001-02-15 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Relaxation der doppelbrechung magnetischer nanopartikel während bindungsreaktionen |
EP1216060A2 (de) | 1999-09-14 | 2002-06-26 | Biomedical Apherese Systeme GmbH | Magnetische nanoteilchen mit biochemischer wirksamkeit und verfahren zu ihrer herstellung sowie ihre verwendung |
US6294342B1 (en) | 1999-09-29 | 2001-09-25 | Abbott Laboratories | Magnetically assisted binding assays utilizing a magnetically responsive reagent |
US6254830B1 (en) | 1999-11-05 | 2001-07-03 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Magnetic focusing immunosensor for the detection of pathogens |
DE60017074T2 (de) * | 2000-03-06 | 2006-03-30 | Medos Sa | Implantierbares Kernresonanz-Spektrometer |
US6548264B1 (en) | 2000-05-17 | 2003-04-15 | University Of Florida | Coated nanoparticles |
US6649419B1 (en) | 2000-11-28 | 2003-11-18 | Large Scale Proteomics Corp. | Method and apparatus for protein manipulation |
AU2002320058A1 (en) * | 2001-06-06 | 2002-12-16 | The General Hspital Corporation | Magnetic-nanoparticle conjugates and methods of use |
US7018849B2 (en) | 2002-01-15 | 2006-03-28 | Piasio Roger N | Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout |
CA2418229A1 (en) * | 2002-05-16 | 2003-11-16 | Rohan Dharmakumar | Microbubble construct for sensitivity enhanced mr manometry |
US6972095B1 (en) | 2003-05-07 | 2005-12-06 | Electric Power Research Institute | Magnetic molecules: a process utilizing functionalized magnetic ferritins for the selective removal of contaminants from solution by magnetic filtration |
US20060020371A1 (en) | 2004-04-13 | 2006-01-26 | President And Fellows Of Harvard College | Methods and apparatus for manipulation and/or detection of biological samples and other objects |
CA2606924C (en) * | 2005-05-09 | 2013-04-16 | The General Hospital Corporation | Water relaxation-based sensors |
JP5295769B2 (ja) * | 2005-08-31 | 2013-09-18 | ティツー・バイオシステムズ・インコーポレーテッド | 分析物を検出するためのnmr装置 |
US20070166730A1 (en) * | 2006-01-19 | 2007-07-19 | Menon & Associates, Inc. | Magnetic resonance system and method to detect and confirm analytes |
-
2006
- 2006-01-20 US US11/335,995 patent/US7781228B2/en active Active
- 2006-01-24 WO PCT/US2006/002368 patent/WO2007086840A2/en active Application Filing
- 2006-01-24 JP JP2008505292A patent/JP5289939B2/ja not_active Expired - Fee Related
- 2006-01-24 CN CN2006800188550A patent/CN101512384B/zh not_active Expired - Fee Related
- 2006-01-24 CA CA2604150A patent/CA2604150C/en active Active
- 2006-01-24 EP EP06849669.4A patent/EP1869466B1/en not_active Not-in-force
- 2006-01-24 ES ES06849669.4T patent/ES2495718T3/es active Active
-
2009
- 2009-10-29 HK HK09110078.5A patent/HK1132552A1/xx not_active IP Right Cessation
-
2010
- 2010-07-15 US US12/837,308 patent/US9442110B2/en active Active
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104487830A (zh) * | 2012-07-02 | 2015-04-01 | 米利开尔文科技有限公司 | 用于磁共振的改良技术、系统和机器可读程序 |
CN103760186A (zh) * | 2012-09-13 | 2014-04-30 | 阿斯派克影像有限公司 | 用于体外诊断应用的使用顺磁剂的工具和方法 |
CN103217530A (zh) * | 2013-03-26 | 2013-07-24 | 南昌大学 | 一种基于顺磁纳米Fe-Co合金探针间接富集的NMR食源性致病菌快速检测方法 |
CN106459896A (zh) * | 2014-02-26 | 2017-02-22 | 布里格姆女子医院有限公司 | 用于磁性自组装的系统和方法 |
CN107110939B (zh) * | 2014-09-11 | 2021-05-14 | 力保科学公司 | 用于测定心血管疾病或事件的风险参数的系统 |
CN107110939A (zh) * | 2014-09-11 | 2017-08-29 | 力保科学公司 | 使用包括hdl和炎症生物标志相互作用参数的风险参数的心血管风险评估 |
US11231429B2 (en) | 2014-09-11 | 2022-01-25 | Liposcience, Inc. | Cardiovascular risk evaluations using a risk parameter that includes an HDL and inflammatory biomarker interaction parameter |
CN106645395A (zh) * | 2016-12-07 | 2017-05-10 | 中国人民解放军军械工程学院 | 基于同轴测试装置的场敏感型电磁脉冲防护材料测试系统 |
CN106645395B (zh) * | 2016-12-07 | 2023-09-19 | 中国人民解放军军械工程学院 | 基于同轴测试装置的场敏感型电磁脉冲防护材料测试系统 |
CN108693491A (zh) * | 2017-04-07 | 2018-10-23 | 康奈尔大学 | 稳健的定量磁化率成像系统和方法 |
CN112804938A (zh) * | 2018-08-08 | 2021-05-14 | 布赖特斯佩克股份有限公司 | 用于低挥发性采样的方法和设备 |
CN111627645A (zh) * | 2020-06-01 | 2020-09-04 | 北京卫星环境工程研究所 | 利用Halbach永磁阵列减小铁磁性材料磁性的方法 |
CN111975805A (zh) * | 2020-08-31 | 2020-11-24 | 哈尔滨工业大学(深圳) | 一种驱动磁性微纳米机器人的磁场操控系统 |
CN114910838A (zh) * | 2021-02-10 | 2022-08-16 | 清华大学 | 磁场增强组件以及磁场增强器件 |
CN114910838B (zh) * | 2021-02-10 | 2024-04-26 | 清华大学 | 磁场增强组件以及磁场增强器件 |
Also Published As
Publication number | Publication date |
---|---|
EP1869466A2 (en) | 2007-12-26 |
CA2604150C (en) | 2013-03-19 |
US20110012596A1 (en) | 2011-01-20 |
CN101512384B (zh) | 2012-05-30 |
US20070020701A1 (en) | 2007-01-25 |
JP5289939B2 (ja) | 2013-09-11 |
US7781228B2 (en) | 2010-08-24 |
WO2007086840A3 (en) | 2009-05-07 |
EP1869466B1 (en) | 2014-08-20 |
EP1869466A4 (en) | 2009-11-11 |
WO2007086840A2 (en) | 2007-08-02 |
JP2008542684A (ja) | 2008-11-27 |
HK1132552A1 (en) | 2010-02-26 |
ES2495718T3 (es) | 2014-09-17 |
US9442110B2 (en) | 2016-09-13 |
CA2604150A1 (en) | 2007-08-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101512384B (zh) | 检测和确认分析物的磁共振系统和方法 | |
CN101578377B (zh) | 检测并确认分析物的磁共振系统和方法 | |
US5972721A (en) | Immunomagnetic assay system for clinical diagnosis and other purposes | |
CN101111769A (zh) | 快速而灵敏的生物感测 | |
CN101896829A (zh) | 传感器盒 | |
CN1914500A (zh) | 用于芯片上磁共振波谱分析的方法和器件 | |
JP2008503714A (ja) | 流体内の関連する物質の存在及び濃度の双方又はいずれか一方を決定する方法 | |
CN104614513A (zh) | 一种基于磁分离的弛豫时间免疫传感分析方法 | |
WO2012129281A2 (en) | Detection of targets using magnetic resonance | |
US20100248345A1 (en) | Particle facilitated testing | |
CN101627297B (zh) | 测量凝集参数 | |
US7148684B2 (en) | Method for biological identification using high temperature superconductor enhanced nuclear quadrupole resonance | |
US20160025825A1 (en) | Nuclear magnetic resonance apparatus and methods | |
Sillerud et al. | Biological detector and method | |
Andò et al. | Investigations into a planar inductive readout strategy for the monitoring of ferrofluid carriers | |
Ludwig et al. | Magnetorelaxometry of magnetic nanoparticles-a new method for the quantitative and specific analysis of biomolecules | |
Salvador Fernández | Biofunctional nanoparticles for magnetic immunoassays: application to the detection of pneumolysin for the rapid diagnosis of pneumococcal pneumonia. | |
Alam et al. | Micro-NMR and Nanoparticle Amplification for Bio-Agent Detection. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1132552 Country of ref document: HK |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1132552 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Owner name: MENON INTERNATIONAL CO., LTD. Free format text: FORMER OWNER: MENON + ASSOCIATES Effective date: 20131120 Owner name: MENON SENSOR CO., LTD. Free format text: FORMER OWNER: MENON INTERNATIONAL CO., LTD. Effective date: 20131120 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20131120 Address after: American California Patentee after: Sensors, Limited by Share Ltd. Address before: American California Patentee before: Meinong International Co.,Ltd. Effective date of registration: 20131120 Address after: American California Patentee after: Meinong International Co.,Ltd. Address before: American California Patentee before: MENON & ASSOCIATES, Inc. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120530 Termination date: 20200124 |
|
CF01 | Termination of patent right due to non-payment of annual fee |