CN101238347A - 执行光学相干层析术中的基于偏振的正交解调的设备、方法和存储介质 - Google Patents
执行光学相干层析术中的基于偏振的正交解调的设备、方法和存储介质 Download PDFInfo
- Publication number
- CN101238347A CN101238347A CNA2006800286977A CN200680028697A CN101238347A CN 101238347 A CN101238347 A CN 101238347A CN A2006800286977 A CNA2006800286977 A CN A2006800286977A CN 200680028697 A CN200680028697 A CN 200680028697A CN 101238347 A CN101238347 A CN 101238347A
- Authority
- CN
- China
- Prior art keywords
- radiation
- signal
- interference
- electromagnetic radiation
- equipment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000010287 polarization Effects 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 36
- 238000012014 optical coherence tomography Methods 0.000 title description 28
- 230000005855 radiation Effects 0.000 claims abstract description 50
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 27
- 230000003287 optical effect Effects 0.000 claims abstract description 21
- 238000001514 detection method Methods 0.000 claims abstract description 14
- 238000001228 spectrum Methods 0.000 claims abstract description 13
- 230000036962 time dependent Effects 0.000 claims description 8
- 239000013307 optical fiber Substances 0.000 claims description 5
- 238000012986 modification Methods 0.000 claims description 3
- 230000004048 modification Effects 0.000 claims description 3
- 238000004587 chromatography analysis Methods 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 32
- 238000003384 imaging method Methods 0.000 description 19
- 238000005516 engineering process Methods 0.000 description 16
- 230000006870 function Effects 0.000 description 16
- 230000008878 coupling Effects 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 238000005859 coupling reaction Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 8
- 230000010363 phase shift Effects 0.000 description 8
- 238000006073 displacement reaction Methods 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 208000007479 Orofaciodigital syndrome type 1 Diseases 0.000 description 5
- 238000005305 interferometry Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 201000003455 orofaciodigital syndrome I Diseases 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000002310 reflectometry Methods 0.000 description 5
- 230000004927 fusion Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 102000057593 human F8 Human genes 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000005055 memory storage Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 229940047431 recombinate Drugs 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02041—Interferometers characterised by particular imaging or detection techniques
- G01B9/02044—Imaging in the frequency domain, e.g. by using a spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02001—Interferometers characterised by controlling or generating intrinsic radiation properties
- G01B9/02002—Interferometers characterised by controlling or generating intrinsic radiation properties using two or more frequencies
- G01B9/02004—Interferometers characterised by controlling or generating intrinsic radiation properties using two or more frequencies using frequency scans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02055—Reduction or prevention of errors; Testing; Calibration
- G01B9/0207—Error reduction by correction of the measurement signal based on independently determined error sources, e.g. using a reference interferometer
- G01B9/02072—Error reduction by correction of the measurement signal based on independently determined error sources, e.g. using a reference interferometer by calibration or testing of interferometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02055—Reduction or prevention of errors; Testing; Calibration
- G01B9/02075—Reduction or prevention of errors; Testing; Calibration of particular errors
- G01B9/02078—Caused by ambiguity
- G01B9/02079—Quadrature detection, i.e. detecting relatively phase-shifted signals
- G01B9/02081—Quadrature detection, i.e. detecting relatively phase-shifted signals simultaneous quadrature detection, e.g. by spatial phase shifting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/0209—Low-coherence interferometers
- G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/21—Polarisation-affecting properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B2290/00—Aspects of interferometers not specifically covered by any group under G01B9/02
- G01B2290/45—Multiple detectors for detecting interferometer signals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B2290/00—Aspects of interferometers not specifically covered by any group under G01B9/02
- G01B2290/70—Using polarization in the interferometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J9/00—Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength
- G01J9/02—Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength by interferometric methods
- G01J2009/0261—Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength by interferometric methods polarised
- G01J2009/0265—Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength by interferometric methods polarised with phase modulation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/45—Interferometric spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
Abstract
设备、方法和存储介质,其可向样品130提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,使得第一和/或第二电磁辐射具有随时间变化的谱。此外,第一辐射所关联的至少一个第三辐射405的第一偏振分量可与第二辐射所关联的至少一个第四辐射400的第二偏振分量彼此相组合。第一和第二偏振可被特定控制为彼此至少近似正交。设备和方法用于扫掠源傅立叶域光学相干层析术的正交检测。
Description
对相关申请的交叉引用
本申请基于并要求了2005年8月9日提交的美国专利申请序列号60/708,271的优先权,通过引用将该美国专利申请的全部公开内容合并于此。
关于联邦赞助研究的声明
实现本发明的研究至少部分得到美国国立卫生研究院的支持,财政补贴号为R33 CA110130和R01 HL076398。因此,美国政府可具有本发明的某些权利。
技术领域
本发明涉及基于光学相干层析技术处理信号的设备、方法和存储介质,尤其涉及可用于混浊的、半混浊的和透明的样品(包括各种生物样品)的高分辨率横截面成像的傅立叶域光学相干层析信号的解调。
背景技术
光学相干层析(“OCT”)技术通常提供分辨率在几微米到几十微米级的生物样品的横截面图像。传统OCT技术如时域OCT(“TD-OCT”)技术可通常使用低相干干涉测量过程来实现样品内的深度范围确定。与之相比,傅立叶域OCT(“FD-OCT”)技术可使用谱雷达过程来实现样品内的深度范围确定。FD-OCT技术由于改进了信噪比性能和省去了机械扫描干涉仪参考臂而允许更高的成像速度。在FD-OCT系统中标准地实施光谱范围确定技术不提供区别相对于干涉测量路径匹配深度作出正和负位移的物体的能力。这种可能的深度简并(或者称为复共轭模糊)可将样品内的成像深度限制为正或负深度(这可防止深度范围确定模糊),从而将固有成像深度有效减小了预定因数(例如二分之一)。
FD-OCT系统中的深度简并的原因可能是只检测样品臂和参考臂之间的通常为复数的干涉条纹的实部。如果检测复干涉图,则可消除或至少减小上述深度简并。已实施了各种解调技术来允许测量复干涉图。这样的传统技术包括相移技术、熔融型3×3耦合器解调技术和频移技术。相移技术通常使用干涉仪中的有源相位调制器元件来动态调节样品臂和参考臂之间的相对相位。可测量并组合不同相移的多个干涉图以产生复干涉图。这种传统技术的缺点之一是干涉图是按时间先后顺序测量的。这种类型的测量降低了系统成像速度,并且使得干涉仪中的相移使测量精确度劣化。熔融型3×3耦合器可在相对于彼此而相移的3个输出端口中的每一个上产生干涉图。该相移可取决于耦合比率。例如,如果相对相位关系是已知的,则可检测并重组这些输出以产生复干涉图。在许多要求精确解调的干涉仪解调机制中,使用高温度、波长和偏振灵敏度的熔融型3×3(通常为熔融型N×N)耦合器受到限制。传统频移技术已成功应用于光学频域成像系统。然而,未曾见到在SD-OCT系统中使用这些技术。这种情况的一个原因是:这样的频移技术通常利用有源元件,并且具有潜在有限的光学带宽。此外,这些技术通常不与用以去除源扫掠非线性的非线性触发直接兼容。
因此,需要克服上述缺陷。
发明内容
为了解决和/或克服上述问题和/或缺陷,提供了根据本发明的系统、方法和软件设置的示例实施例,用于执行FD-OCT干涉测量输出的全光学无源正交解调。可利用特定光学元件在光学上产生复干涉图的正交分量。这些正交输出的检测和适当重组可允许测量复干涉图。这样,本发明的示例实施例帮助消除了或至少减小了由深度简并导致的图像范围限制。
当在光学频域成像(“OFDI”)系统中使用时,本发明的示例实施例允许用于去除或减小源强度噪声的平衡检测以及偏振分集检测。本发明的示例实施例可与非线性触发相组合以便帮助例如大为减少后处理需求,这对于高速成像是重要的。
当与SD-OCT系统一起使用时,本发明的示例实施例帮助增大(例如加倍)成像深度范围。
因此,根据本发明的一个示例实施例,一种设备、方法和存储介质,其可向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,使得第一和/或第二电磁辐射具有随时间变化的谱。此外,第一辐射所关联的至少一个第三辐射的第一偏振分量可与第二辐射所关联的至少一个第四辐射的第二偏振分量彼此相组合。第一和第二偏振可被特定控制为彼此至少近似正交。
此外,可检测根据第一和第二偏振分量之间的干涉得出的至少一个信号。可根据预定数据将该信号和/或另外信号分别修改为第一经修改信号和/或第二经修改信号。可获得作为该信号和/或另外信号的多个信号,可确定该多个信号的统计特性,且可基于该统计特性得出该预定数据。
根据本发明的另一个示例实施例,第一和第二经修改信号的相位差可比该信号和/或第一信号的相位之间的差更接近约np+p/2,其中n是整数且大于或等于0。该干涉和另外干涉的相位可彼此大为不同。该干涉和另外干涉的相位差可基本上是np+p/2,其中n是整数且大于或等于0。第三辐射的至少一部分和第四辐射可具有相对于彼此的至少一个延迟,且可根据该延迟、该信号和另外信号来产生图像。该延迟可包括至少一个正段和至少一个负段,且可区别该图像的具有正和负段的至少诸部分。可测量该延迟的符号和量值。
根据本发明的再一个实施例,一种装置、方法和存储装置可向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,使得第一和/或第二电磁辐射具有随时间变化的谱。此外,第一信号可根据第一辐射所关联的至少一个第三辐射和第二辐射所关联的至少一个第四辐射之间的第一干涉来产生,且第二信号可根据关联的第三辐射和第四辐射之间的第二干涉来产生。第一和第二干涉可彼此不同。可提供一种关联有双折射的装置,用于根据双折射来特定控制第一和第二干涉的不包括np在内的相位差,其中n是整数且大于或等于0。
通过阅读以下结合所附权利要求对本发明诸实施例的详细描述,本发明的这些和其它目的、特征和优点将变得显而易见。
附图说明
根据以下结合示出本发明的说明性实施例的附图进行的详细描述,本发明的其它目的、特征和优点将变得显而易见,在附图中:
图1a是FD-OCT系统示意图的示例实施例的框图;
图2是根据本发明的使用块状光学部件的基于偏振的解调光学装置的示例实施例的框图;
图3是被修改为允许用于减去源噪声的平衡检测的图2中的装置的另一个示例实施例的框图;
图4是被修改为允许平衡检测和偏振分集检测二者的图3中的装置的又一个示例实施例的框图;
图5是可与图4中的装置在功能上等价并且被修改为大部分或全部使用纤维光学部件的光学解调装置的另一个示例实施例的框图;
图6是被修改为合并了用于校准任何在图2-5中示出的示例装置的相位调制器的根据本发明的FD-OCT系统的再一个示例实施例的框图;
图7是用于校准本发明的示例系统以及操作这些系统的根据本发明的示例方法的示例实施例的流程图;
图8是可使用任何根据本发明的示例解调光学装置的根据本发明的OFDI系统的一个示例实施的框图;
图9A-9D是从图8中的示例系统接收到的示例所测得A线(A-Iines)的曲线图;
图10A是在有和没有啁啾时钟的情况下示出的示例所测得轴向点扩展函数的曲线图;
图10B是对于无啁啾(例如恒定电压曲线)时钟和啁啾时钟的示例压控振荡器(“VCO”)驱动波形的曲线图;以及
图11A和11B分别是在使用和不使用复解调的情况下的人皮肤图像。
在所有附图中,除非另有说明,使用相同的参考数字和字符来表示诸图示实施例中同样的特征、元件、部件或部分。而且,将参考附图并结合说明性实施例对本发明进行详细描述。意图是可在不背离由所附权利要求限定的本发明的真实范围和精神的情况下对所描述的实施例进行改变和修改。
具体实施方式
本发明的示例实施例的理论
傅立叶域OCT技术通常使用谱雷达技术实现深度范围确定,在谱雷达技术中,来自样品的反射与参考臂干涉,且所得干涉图可作为光波长的函数而被测量。图1示意性示出了根据本发明的FD-OCT系统的示例实施例。图1中的示例系统包括源100,源100产生输出,耦合器105将该输出分到样品臂和参考臂中。样品臂光可被引导至待成像样品130。可使用聚焦透镜125来实现高横向分辨率。来自此样品的反射由同一光纤收集,并返回,经过第二耦合器115到输出耦合器110。参考臂光被输入到此输出耦合器110的另一个端口上。接收器120将干涉作为波长的函数来进行检测。在根据本发明的OFDI系统的示例实施例中,此接收器可以是单个光电接收器,该单个光电接收器将输出作为时间的函数来进行检测,同时窄带源将其输出波长作为时间的函数来进行扫掠。在根据本发明的SD-OCT系统的示例实施例中,该接收器可以是光谱仪,其通过使用光栅和行扫描相机来记录许多波长的功率。对于深度z处的反射(其中z=0对应于样品臂光和参考臂光之间的零路径长度失配),作为波数k的函数的接收器输出的干涉项可由下式给出:
其中P(k)是源功率,Rref是包括从源到接收器的耦合损耗的参考臂功率透射率,Rs是由深度z处的反射导致的样品臂功率反射率,z是样品臂反射率的相位。
反射的幅度和深度可由作为波数的函数的所测得信号的量值和频率给出。对适当减去了非干涉测量项的检测到的条纹进行傅立叶变换(FT)可得到作为深度的函数的复反射率a(z):
a(z′)=FT(S(k))
以所得频率(正频率或负频率)的符号来对深度位置的符号(z的符号)进行编码。由于S(k)是实数值,所以会难以区分正和负频率。因此,可能不能区分+z处的反射率和-z处的反射率。这是产生傅立叶域OCT技术的深度简并的原因。检测正交输出(例如相位彼此相位差90°的干涉信号)可去除此深度简并。考虑检测正交分量SQ(k)和SI(k),
由于是复数,所以有可能区分正和负频率,并因此消除正和负深度之间的简并。在传统FD-OCT系统中,图像深度被限制于正深度以防止正和负深度的信号之间的简并/模糊。这样的传统系统中的最大成像范围受到条纹冲蚀(washout)的限制,条纹冲蚀是增大深度导致的信号幅度减小。于是,传统FD-OCT系统中的成像深度在z=0到z=+z1之间。使用根据本发明的复解调技术的示例实施例,可减小或去除深度简并,这允许从-z1到+z1发生成像,从而提供了传统FD-OCT系统的图像深度范围的两倍。
光学解调回路/装置的示例实施例
根据本发明的示例实施例,可提供一种光学回路/装置,用于产生可用于复解调的正交信号SQ(k)和SI(k)。图2示出了一个这样的示例实施例,其涉及一种光学解调回路/装置。在此示例回路装置中,参考臂光由准直光学器件415准直,并被引导至偏振分束器(“PBS”)420的第一端口420b。偏振控制器401使得参考臂光能够反射到输出端口420c。此示例回路/装置所产生的样品臂405光由准直光学器件410准直,并被引导至PBS 420的第二输入端口420a。样品臂中的S偏振光可被引导至输出端口420c。经组合的参考和样品臂光传播至分束器(例如非偏振分束器)425,分束器425可将该光分裂成基本上相等的部分,到输出端口425a、425b。端口425a上输出的光穿过第一双折射元件430,然后到偏振器435,偏振器435的取向使得透射偏振态处在像平面的法向上。然后该光由输出光纤460通过聚焦光学器件450收集。随后此收集光由检测器461检测,检测器461可包括适用于谱域OCT系统的光谱仪或适用于光学频域成像系统的单个光电接收器。相似的分析可应用于从端口425b出射的光,该光可到达双折射元件(1)440,最终由检测器466进行检测。
对于位置z处单个反射率而言的输出2上的检测到的干涉信号可提供为:
其中B2(k)和x2(k)是双折射元件2 430的函数。光纤465上的输出1可类似提供为:
其中B1(k)和x1(k)是双折射元件(1)440的函数。适当选择双折射元件可便利于输出相对相移为90°的信号。例如,如果双折射元件(1)440被选择为四分之一波片,其取向为快或慢轴与像平面法向矢量成45°,且双折射元件(2)430被选择为45°法拉第旋转器,那么输出之间的相位差x2(k)-x1(k)约为90°,且B1(k)=B2(k),由此提供下式:
本领域普通技术人员应理解,可使用双折射元件(1)和(2)的其它组合来产生正交信号,且亦可调节偏振器445、435的取向以产生正交信号。这些信号可在检测后被组合以产生根据本发明的复干涉信号。
图3示出了被配置为实现带有用于从样品中去除自相关噪声以及源强度噪声的平衡检测的正交检测的根据本发明的解调光学回路/装置的另一个示例实施例。除了图4中的偏振器已由偏振分束器(PBS)立方体500、530代替之外,图3中的装置的工作基本上相似于图2中的装置的工作。可检测PBS立方体500的两个输出端口,且优选地在平衡接收器中减去它们的信号。在此示例配置中,可增大干涉信号,且可减去来自噪声的噪声波动。此示例装置的平衡接收器525、555的输出提供待组合形成复干涉信号的正交干涉信号。
图4示出了作为图3中的装置的修改的根据本发明的光学回路装置的另一个示例实施例。特别而言,图4中的装置允许检测偏振分集。偏振分集使得能够检测可由两种偏振的样品臂光引起的干涉条纹。图4中的装置的偏振控制器600可被配置为将参考臂功率的基本上相等的部分引导至第一PBS 601的两个输出端口。第一PBS 601的各输出端口检测以给定偏振到达的样品臂光。回路590与图3中所示的回路基本上相同,并且可在第四PBS输出端口592上重复。在此示例配置中,输出A和B描述一种信号偏振,而输出C和D描述另一种信号偏振。
图5示出了可与图4中的回路/装置在功能上等价或相似并且由纤维光学部件构造的根据本发明的解调光学回路/装置的另一个示例实施例。例如,图4中的双折射元件可由偏振控制器610a、615a、610b、615b代替,调节这些偏振控制器使得在输出端口625a和625b上产生正交信号,并同样可在输出端口625c和625d上产生正交输出。
在利用块状光学双折射元件的示例配置(如图2-4所示)中,双折射元件可选择为产生相移为90°的正交分量。在图5中的纤维光学配置中,在可监视干涉条纹时可调节偏振控制器,使得引入约90°相移。可如下面所述那样测量并校正相对于90°的相移偏差。
校准
例如,所测得信号不准确正交,因此必须使用校准过程来根据所测得信号产生正交信号。假设所测得信号由下式给出:
SQ(k)=AQ(k)+BQ(k)cos(φ)
SI(k)=AI(k)+BI(k)sin(φ+ζ(k))
其中φ是包含深度信息的干涉测量相位差。参数AQ、BQ、AI、BI和ζ可由源谱和解调回路确定。如果这些参数是已知的,则准确正交信号可构造如下:
S′Q=BQcos(φ)=SQ-AQ
其中,为了清楚起见,这里没有描述这些参数对k的显式依赖。AQ和AI可使用下列方法中的任一种来测量:
(a)阻挡样品臂光,且可将输出记录为k的函数。由于返回的样品臂功率比参考臂功率小得多,所以AQ(k)和AI(k)无任何干涉地由检测到的参考臂功率来确定;并且/或者
(b)可通过记录具有或没有来自样品臂的反射的信号、并对相当大数目的测量结果取平均来测量参数AQ(k)和AI(k)。因为干涉项由于干涉仪漂移而平均值为0,所以该平均产生AQ和AI。可替选地,可在干涉仪中在参考臂或样品臂中放置相位调制器。图6图示了包括放置在参考臂中的相位调制器700的回路/装置的这种示例实施例。此相位调制器700可用来确保:经过测量A的时间段,干涉仪相位被随机化。如果经过一个A线的时间段,相位调制比π小得多,则此相位调制器700可在成像期间保持工作。否则,应在成像过程中关断相位调制器700。
可理想地在有图6中的相位调制器700的情况下、要么经过足以确保相位随机分布的足够长时间,通过记录具有样品臂中的反射的输出来测量BQ(k)与BI(k)之比。该比率可提供如下:
其中
参数ζ可计算如下:
图7示出了用以执行这种确定的根据本发明的过程的示例实施例。特别而言,在步骤655中,偏振控制器(“PC”)可被配置为提供定相于约90度的输出信号(如果利用图5中的光纤配置)。在步骤600中,在调制参考臂位置或相位时测量信号SQ(k)和SI(k)。在步骤665中,利用上面的公式(2)和(3)计算:AQ(k)=<SQ(k)>和AI(k)=<SI(k)>。这些步骤在系统校准期间执行。下面描述的步骤在使用本系统期间执行。例如,在步骤670中,测量信号SQ(k)与SI(k),在步骤675中,使用等式(1)计算条纹。然后,在步骤680中,构造复信号SQ′+sqrt(-1)*SI′。
图8示出了根据本发明的系统的(例如示例OFDI系统的)示例实施例。例如,可以为该示例系统提供扫过105nm、中心在1325nm的激光器700输出。此示例源可被分到样品臂705(例如90%)和参考臂710(例如10%)中。参考臂光的一部分可被引导至光纤布拉格光栅(“FBG”)715,从而产生反射光脉冲,该反射光脉冲被检测并转换成TTL触发信号。参考臂光的剩余部分可穿过可变光学延迟(例如,用来路径长度匹配干涉仪),并被提供于尾纤式偏振合束器(“PBC”)720的一个端口上。参考臂710中的偏振控制器725(“PC”)可用来使参考臂光与PBC输出端口的耦合最大化。反射样品臂光被引导至PBC的另一个输入端口。此光的一种偏振态可耦合到PBC输出端口。PBC之后是光学解调回路,该光学解调回路使用基于偏振的偏置来产生各干涉条纹的同相信号SI和正交信号SQ。
照这样,可构造复干涉信号(SI+iSQ)。由于该复信号指示相位流的方向,所以其允许明确区别正和负光学延迟并且消除深度简并。为了说明该解调回路,在图8中的第一PBC的输出端口上,参考臂光和样品臂光可正交地偏振,并因此光的偏振态而不是强度被调制。此光可被50/50耦合器730分裂,且各输出可被引导至PC 735a、735b,PC 735a、735b之后的偏振分束器(PBS)740a、740b将偏振调制转换成强度调制。任意地,将来自上方路径的信号定义为SI,来自下方路径的信号定义为SQ。在各路径中,偏振控制器735a、735b被设置成在PBS 740a、740b的两个输出端口之间均分参考臂光,且输出连接到平衡接收器745a、745b以减去强度噪声。在在输出端口之间等分参考臂功率这一约束下,SI和SQ的相位可通过操控对应的PC来任意设置。在我们的系统中,可能在SI和SQ之间引入90°的相对定相。
使用所测得信号SI和SQ来直接形成复干涉信号(例如无任何检测后校正的复干涉信号)可导致正和负深度之间的适度消光。图9A示出了通过直接使用所测得信号SI和SQ计算出的+1.7mm深度处的固定反射镜的所测得A线的曲线图。此曲线图中示出的所得消光为30 dB。为了改善消光,可使用描述光学解调回路的状态的先前获取的校准数据、根据所测得信号SI和SQ计算出经校正信号给定波数k的同相信号可由SI=Bsin(φ)给出,且正交信号由SQ=αBcos(φ-ε)给出,其中α和ε描述SQ相对于真实正交信号的偏差(对于真实正交信号,α=1且ε=0)。可假设DC分量已被减去。对于所测得同相信号SI,经校正正交信号由下式给出:
可使用统计方法针对光学解调回路的给定设置来测量参数α和ε(都是波数k的函数)。当用压电平移器将参考臂位置缓慢位移几个微米时,在有样品臂反射的情况下可记录多个干涉条纹。所得数据集可包含其中相位(φ)呈准随机化分布(由参考臂抖动引起)的各波数的信号SQ和SI。于是校准参数可统计地计算如下:
其中σx是所测得信号x的标准偏差(遍及样本数目),并且是波数的函数。在这些实验中,用30Hz三角波形将参考镜平移几个微米,且经过3秒的时间段、在15.6kHz的A线速率下记录信号。图9B示出了与图9A中的A线相同的A线,但使用经校正的复信号消光从30dB改善为大于50dB。图9C和9D示出了在+0.4mm和-1.3mm的反射镜深度处测得的A线。图9B-9D中的每一个使用相同的先前导出的校准参数α和ε,并且实现了大于50dB的消光。利用光学解调回路的适当环境防护,校准系数经过大于60分钟的时段仍保持有效。测得系统的灵敏度从+0.2mm深度附近的107dB变化到+2.0mm深度处的103dB。
为了示范啁啾时钟采样,提供了使用压控振荡器电路的时钟发生器750(见图8)。输出时钟频率通过模拟电压输入来控制,且可用平滑变化的模拟输入波形来相位连续地扫掠输出时钟频率。此波形由数据采集(DAQ)765电子器件产生,且对于源的每次扫掠重复此波形。该波形由用于数据采集的同一触发信号触发,并因此与源扫掠同步。图10A示出了使用恒定频率时钟信号和啁啾频率时钟信号二者的相对于零差分延迟点位移约-1.1mm的反射镜的所测得轴向点扩展函数。图10B示出了对于恒定频率和啁啾频率时钟信号的输入到VCO时钟电路的模拟波形。使用直接迭代例程针对源的给定配置设置寻找最佳VCO模拟波形。此波形在源被重新配置之前都保持有效。使用啁啾频率时钟信号,测得轴向分辨率在空气中为13.5-14.5μm,且轴向分辨率在整个成像深度范围内是变形有限的。
图11示出了在15.6kHz的A线速率下采集到的人手指活体图像。图像大小为:5mm横向大小×4.3mm深度(500×408)。深度分辨率在空气中为14μm,而横向分辨率为25μm。成像帧速率为30fps。在图11A中,仅基于同相信号SI产生图像,从而表现出深度简并效应。在图11B中,使用了复信号并且去除了深度简并伪影,从而允许4.3mm内的清晰成像。
前面仅说明了本发明的原理。鉴于这里的教导,对所述实施例的各种修改和变更将对于本领域技术人员而言显而易见。无庸置疑,根据本发明示例实施例的装置、系统和方法可与任何OCT系统、OFDI系统、SD-OCT系统或其它成像系统一起使用,并且可例如与2004年9月8日提交的国际专利申请PCT/US2004/029148、2005年11月2日提交的美国专利申请No.11/266,779和2004年7月9日提交的美国专利申请No.10/501,276中所描述的装置、系统和方法一起使用,这些申请的公开内容通过引用整体合并于此。因此,应理解,本领域技术人员应能够设计尽管这里未明确示出或描述但体现了本发明原理并因此落入本发明的精神和范围内的许多系统、装置和方法。此外,就现有技术知识未通过引用明确合并于上文而言,其整体明确合并于此。上文引用的所有出版物通过引用整体合并于此。
Claims (28)
1.一种设备,包括:
至少一个第一装置,其能够向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,其中所述第一和第二电磁辐射中的至少一种具有随时间变化的谱;以及
至少一个第二装置,其能够将所述至少一个第一辐射所关联的至少一个第三辐射的第一偏振分量与所述至少一个第二辐射所关联的至少一个第四辐射的第二偏振分量彼此相组合,其中所述第一和第二偏振被特定控制为彼此至少近似正交。
2.根据权利要求1的设备,还包括至少一个第三装置,其能够检测根据所述第一和第二偏振分量之间的干涉得出的至少一个信号。
3.根据权利要求2的设备,其中所述至少一个第三装置还能够检测根据所述第一和第二偏振分量之间的另外干涉得出的至少一个另外信号。
4.根据权利要求3的设备,其中所述第三装置还能够根据预定数据将所述至少一个信号或所述至少一个另外信号中的至少一种分别修改为第一经修改信号或第二经修改信号中的至少一种。
5.根据权利要求4的设备,其中所述预定数据基于所述第三装置的特征或状态中的至少一种来获得。
6.根据权利要求3的设备,其中所述第三装置还能够获得作为所述至少一个信号或所述至少一个另外信号中的至少一种的多个信号、确定所述多个信号的统计特征、并且基于所述统计特征得出所述预定数据。
7.根据权利要求4的设备,其中所述第一和第二经修改信号的相位差比所述至少一个信号或所述至少一个第一信号的相位之间的差更接近约nπ+π/2,其中n是整数且大于或等于0。
8.根据权利要求3的设备,其中所述干涉和所述另外干涉的相位分别彼此大为不同。
9.根据权利要求3的设备,其中所述干涉和所述另外干涉的相位差分别基本上是nπ+π/2,其中n是整数且大于或等于0。
10.根据权利要求3的设备,其中所述第三辐射的至少一部分和所述第四辐射具有相对于彼此的至少一个延迟,并且还包括能够根据所述延迟、所述信号和所述另外信号产生图像的至少一个第四装置。
11.根据权利要求10的设备,其中所述至少一个延迟包括至少一个正段和至少一个负段,并且其中所述至少一个第四装置能够区别所述图像的具有正和负段的至少诸部分。
12.根据权利要求11的设备,其中所述至少一个第四装置能够测量所述至少一个延迟的符号和量值。
13.一种设备,包括:
至少一个第一装置,其能够向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,其中所述第一和第二电磁辐射中的至少一种具有随时间变化的谱;
至少一个第二装置,其能够根据所述至少一个第一辐射所关联的至少一个第三辐射和所述至少一个第二辐射所关联的至少一个第四辐射之间的第一干涉来产生第一信号、并且根据关联的所述至少一个第三辐射和所述至少一个第四辐射之间的第二干涉来产生第二信号,所述第一和第二干涉彼此不同;以及
至少一个第三装置,其关联有双折射,并且能够根据所述双折射来特定控制所述第一和第二干涉的不包括nπ在内的相位差,其中n是整数且大于或等于0。
14.根据权利要求13的设备,其中所述至少一个第三装置包括光纤偏振控制器和块状光学双折射装置中的至少一种。
15.一种方法,包括:
向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,其中所述第一和第二电磁辐射中的至少一种具有随时间变化的谱;并且
将所述至少一个第一辐射所关联的至少一个第三辐射的第一偏振分量与所述至少一个第二辐射所关联的至少一个第四辐射的第二偏振分量彼此相组合,其中所述第一和第二偏振被特定控制为彼此至少近似正交。
16.根据权利要求15的方法,还包括检测根据所述第一和第二偏振分量之间的干涉得出的至少一个信号。
17.根据权利要求16的方法,还包括检测根据所述第一和第二偏振分量之间的另外干涉得出的至少一个另外信号。
18.根据权利要求17的方法,还包括根据预定数据将所述至少一个信号或所述至少一个另外信号中的至少一种分别修改为第一经修改信号或第二经修改信号中的至少一种。
19.根据权利要求17的方法,还包括获得作为所述至少一个信号或所述至少一个另外信号中的至少一种的多个信号、确定所述多个信号的统计特征、并且基于所述统计特征得出所述预定数据。
20.根据权利要求17的方法,其中所述第一和第二经修改信号的相位差比所述至少一个信号或所述至少一个第一信号的相位之间的差更接近约nπ+π/2,其中n是整数且大于或等于0。
21.根据权利要求17的方法,其中所述干涉和所述另外干涉的相位分别彼此大为不同。
22.根据权利要求17的方法,其中所述干涉和所述另外干涉的相位差分别基本上是nπ+π/2,其中n是整数且大于或等于0。
23.根据权利要求17的方法,其中所述第三辐射的至少一部分和所述第四辐射具有相对于彼此的至少一个延迟,并且还包括根据所述延迟、所述信号和所述另外信号产生图像。
24.根据权利要求23的方法,其中所述至少一个延迟包括至少一个正段和至少一个负段,并且还包括区别所述图像的具有正和负段的至少诸部分。
25.根据权利要求24的方法,还包括测量所述至少一个延迟的符号和量值。
26.一种方法,包括:
向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,其中所述第一和第二电磁辐射中的至少一种具有随时间变化的谱;
根据所述至少一个第一辐射所关联的至少一个第三辐射和所述至少一个第二辐射所关联的至少一个第四辐射之间的第一干涉来产生第一信号、并且根据关联的所述至少一个第三辐射和所述至少一个第四辐射之间的第二干涉来产生第二信号,所述第一和第二干涉彼此不同;并且
利用关联有双折射的装置,根据所述双折射来特定控制所述第一和第二干涉的不包括nπ在内的相位差,其中n是整数且大于或等于0。
27.一种存储介质,其上设有软件,其中所述软件能够由处理装置执行以执行下列步骤:
向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,其中所述第一和第二电磁辐射中的至少一种具有随时间变化的谱;并且
将所述至少一个第一辐射所关联的至少一个第三辐射的第一偏振分量与所述至少一个第二辐射所关联的至少一个第四辐射的第二偏振分量彼此相组合,其中所述第一和第二偏振被特定控制为彼此至少近似正交。
28.一种存储介质,其上设有软件,其中所述软件能够由处理装置执行以执行下列步骤:
向样品提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射,其中所述第一和第二电磁辐射中的至少一种具有随时间变化的谱;
根据所述至少一个第一辐射所关联的至少一个第三辐射和所述至少一个第二辐射所关联的至少一个第四辐射之间的第一干涉来产生第一信号、并且根据关联的所述至少一个第三辐射和所述至少一个第四辐射之间的第二干涉来产生第二信号,所述第一和第二干涉彼此不同;并且
利用关联有双折射的装置,根据所述双折射来特定控制所述第一和第二干涉的不包括nπ在内的相位差,其中n是整数且大于或等于0。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70827105P | 2005-08-09 | 2005-08-09 | |
US60/708,271 | 2005-08-09 | ||
PCT/US2006/031275 WO2007019574A2 (en) | 2005-08-09 | 2006-08-09 | Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101238347A true CN101238347A (zh) | 2008-08-06 |
CN101238347B CN101238347B (zh) | 2011-05-25 |
Family
ID=37603357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800286977A Expired - Fee Related CN101238347B (zh) | 2005-08-09 | 2006-08-09 | 执行光学相干层析术中的基于偏振的正交解调的设备、方法和存储介质 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9441948B2 (zh) |
EP (3) | EP2207008A1 (zh) |
JP (2) | JP5547402B2 (zh) |
KR (1) | KR101387454B1 (zh) |
CN (1) | CN101238347B (zh) |
AT (1) | ATE484727T1 (zh) |
DE (1) | DE602006017558D1 (zh) |
ES (1) | ES2354287T3 (zh) |
WO (1) | WO2007019574A2 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102188237A (zh) * | 2011-05-26 | 2011-09-21 | 浙江大学 | 基于位相复用的全量程扫频oct成像方法及系统 |
CN102273105A (zh) * | 2009-01-12 | 2011-12-07 | 阿卡特朗讯美国公司 | 具有共享的光学混合器及多波长本机振荡器的多波长相干接收器 |
CN103829924A (zh) * | 2012-11-26 | 2014-06-04 | 三星电子株式会社 | 用于产生断层图像的设备和方法 |
CN104205678A (zh) * | 2012-04-13 | 2014-12-10 | 阿尔卡特朗讯 | 非线性交叉偏振减轻算法 |
CN104641580A (zh) * | 2012-09-14 | 2015-05-20 | 阿尔卡特朗讯 | 通过线性光学采样的光学信号可视化 |
CN104205678B (zh) * | 2012-04-13 | 2016-11-30 | 阿尔卡特朗讯 | 非线性交叉偏振减轻算法 |
CN110456468A (zh) * | 2019-09-17 | 2019-11-15 | 安徽光纤光缆传输技术研究所(中国电子科技集团公司第八研究所) | 一种量子光器件空间混合集成组件 |
CN110960186A (zh) * | 2018-09-28 | 2020-04-07 | 株式会社多美 | 眼科装置 |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002230842A1 (en) | 2000-10-30 | 2002-05-15 | The General Hospital Corporation | Optical methods and systems for tissue analysis |
US7447408B2 (en) | 2004-07-02 | 2008-11-04 | The General Hospital Corproation | Imaging system and related techniques |
EP2272421A1 (en) | 2004-08-24 | 2011-01-12 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
US8922781B2 (en) * | 2004-11-29 | 2014-12-30 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
US7336366B2 (en) * | 2005-01-20 | 2008-02-26 | Duke University | Methods and systems for reducing complex conjugate ambiguity in interferometric data |
JP2008538612A (ja) * | 2005-04-22 | 2008-10-30 | ザ ジェネラル ホスピタル コーポレイション | スペクトルドメイン偏光感受型光コヒーレンストモグラフィを提供することの可能な構成、システム、及び方法 |
KR101410867B1 (ko) | 2005-04-28 | 2014-06-23 | 더 제너럴 하스피탈 코포레이션 | 광간섭 정렬 기술로 해부학적 구조와 연계된 정보를평가하는 시스템, 공정 및 소프트웨어 배열 |
EP1889037A2 (en) * | 2005-06-01 | 2008-02-20 | The General Hospital Corporation | Apparatus, method and system for performing phase-resolved optical frequency domain imaging |
DE602006017558D1 (de) | 2005-08-09 | 2010-11-25 | Gen Hospital Corp | Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie |
WO2007022220A2 (en) * | 2005-08-16 | 2007-02-22 | The General Hospital Corporation | Arrangements and methods for imaging in vessels |
EP1937137B1 (en) * | 2005-09-29 | 2022-06-15 | General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US8145018B2 (en) | 2006-01-19 | 2012-03-27 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements |
EP1973467B1 (en) * | 2006-01-20 | 2013-10-16 | The General Hospital Corporation | Systems and process for providing speckle reduction using a wave front modulation for optical coherence tomography |
EP2659852A3 (en) | 2006-02-01 | 2014-01-15 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
US10426548B2 (en) | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
WO2007101026A2 (en) | 2006-02-24 | 2007-09-07 | The General Hospital Corporation | Methods and systems for performing angle-resolved fourier-domain optical coherence tomography |
JP2007240228A (ja) * | 2006-03-07 | 2007-09-20 | Fujifilm Corp | 光断層画像化装置 |
WO2007133961A2 (en) | 2006-05-10 | 2007-11-22 | The General Hospital Corporation | Processes, arrangements and systems for providing frequency domain imaging of a sample |
WO2008049118A2 (en) | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s) |
US8705047B2 (en) | 2007-01-19 | 2014-04-22 | Thorlabs, Inc. | Optical coherence tomography imaging system and method |
US7936462B2 (en) * | 2007-01-19 | 2011-05-03 | Thorlabs, Inc. | Optical coherence tomography imaging system and method |
EP2309923B1 (en) | 2008-07-14 | 2020-11-25 | The General Hospital Corporation | Apparatus and methods for color endoscopy |
US8937724B2 (en) | 2008-12-10 | 2015-01-20 | The General Hospital Corporation | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling |
WO2010090837A2 (en) | 2009-01-20 | 2010-08-12 | The General Hospital Corporation | Endoscopic biopsy apparatus, system and method |
JP5726238B2 (ja) * | 2009-06-25 | 2015-05-27 | キヤノン株式会社 | 撮像装置及び撮像方法 |
JP5819823B2 (ja) | 2009-07-14 | 2015-11-24 | ザ ジェネラル ホスピタル コーポレイション | 血管の内部の流れおよび圧力を測定する装置および装置の作動方法 |
JP5629455B2 (ja) * | 2009-12-14 | 2014-11-19 | キヤノン株式会社 | 干渉計 |
EP2542145B1 (en) | 2010-03-05 | 2020-08-12 | The General Hospital Corporation | Systems which provide microscopic images of at least one anatomical structure at a particular resolution |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
WO2011150069A2 (en) | 2010-05-25 | 2011-12-01 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images |
WO2011149972A2 (en) | 2010-05-25 | 2011-12-01 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
US8854629B2 (en) * | 2010-11-17 | 2014-10-07 | Finisar Corporation | Optical coherence tomography system and method |
WO2013013049A1 (en) | 2011-07-19 | 2013-01-24 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
CN102322801B (zh) * | 2011-08-09 | 2012-12-12 | 天津大学 | 高信噪比摆动式低相干干涉位移解调装置及其解调方法 |
WO2013066631A1 (en) | 2011-10-18 | 2013-05-10 | The General Hospital Corporation | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
US9023016B2 (en) | 2011-12-19 | 2015-05-05 | Alcon Lensx, Inc. | Image processor for intra-surgical optical coherence tomographic imaging of laser cataract procedures |
US9066784B2 (en) * | 2011-12-19 | 2015-06-30 | Alcon Lensx, Inc. | Intra-surgical optical coherence tomographic imaging of cataract procedures |
TWI554244B (zh) * | 2011-12-19 | 2016-10-21 | 愛爾康眼科手術激光股份有限公司 | 用於雷射白內障程序之手術內光學同調斷層掃描成像的影像處理器 |
US8896841B2 (en) * | 2012-03-13 | 2014-11-25 | Kabushiki Kaisha Topcon | Optical imaging method and optical imaging apparatus using optical coherence tomography |
WO2013148306A1 (en) | 2012-03-30 | 2013-10-03 | The General Hospital Corporation | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
US11490797B2 (en) | 2012-05-21 | 2022-11-08 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
JP6227652B2 (ja) | 2012-08-22 | 2017-11-08 | ザ ジェネラル ホスピタル コーポレイション | ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体 |
JP6038619B2 (ja) * | 2012-12-04 | 2016-12-07 | 株式会社日立エルジーデータストレージ | 偏光感受型光計測装置 |
JP6560126B2 (ja) | 2013-01-28 | 2019-08-14 | ザ ジェネラル ホスピタル コーポレイション | 光周波数ドメインイメージングに重ね合わせされる拡散分光法を提供するための装置および方法 |
US10893806B2 (en) | 2013-01-29 | 2021-01-19 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
WO2014121082A1 (en) | 2013-02-01 | 2014-08-07 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
JP6378311B2 (ja) | 2013-03-15 | 2018-08-22 | ザ ジェネラル ホスピタル コーポレイション | 物体を特徴付ける方法とシステム |
WO2014186353A1 (en) | 2013-05-13 | 2014-11-20 | The General Hospital Corporation | Detecting self-interefering fluorescence phase and amplitude |
EP4349242A2 (en) | 2013-07-19 | 2024-04-10 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
WO2015013651A2 (en) | 2013-07-26 | 2015-01-29 | The General Hospital Corporation | System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography |
JP6186215B2 (ja) * | 2013-09-04 | 2017-08-23 | 株式会社日立エルジーデータストレージ | 光計測装置及び光断層観察方法 |
US9625380B2 (en) * | 2013-09-04 | 2017-04-18 | Hitachi, Ltd. | Optical coherence tomography with homodyne-phase diversity detection |
JP6188521B2 (ja) * | 2013-10-02 | 2017-08-30 | 株式会社日立エルジーデータストレージ | 光計測装置 |
CN104677834A (zh) * | 2013-11-26 | 2015-06-03 | 北京智朗芯光科技有限公司 | 一种利用全穆勒矩阵椭圆偏振仪进行光学测量的方法 |
US9733460B2 (en) | 2014-01-08 | 2017-08-15 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
CN103776474A (zh) * | 2014-01-10 | 2014-05-07 | 江苏昂德光电科技有限公司 | 一种3d矩阵式多通道光纤传感解调系统 |
US10317189B2 (en) * | 2014-01-23 | 2019-06-11 | Kabushiki Kaisha Topcon | Detection of missampled interferograms in frequency domain OCT with a k-clock |
US10736494B2 (en) | 2014-01-31 | 2020-08-11 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
JP6227449B2 (ja) * | 2014-03-14 | 2017-11-08 | 株式会社日立エルジーデータストレージ | 光断層観察装置 |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
JP6261450B2 (ja) * | 2014-05-30 | 2018-01-17 | 株式会社トーメーコーポレーション | 眼科装置 |
KR102513779B1 (ko) | 2014-07-25 | 2023-03-24 | 더 제너럴 하스피탈 코포레이션 | 생체 내 이미징 및 진단을 위한 장치, 디바이스 및 방법 |
JP6463051B2 (ja) * | 2014-09-10 | 2019-01-30 | 株式会社トーメーコーポレーション | 光断層画像撮影装置 |
ES2913531T3 (es) | 2015-04-16 | 2022-06-02 | Gentuity Llc | Sondas microópticas para neurología |
WO2017040484A1 (en) | 2015-08-31 | 2017-03-09 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
JP7158283B2 (ja) | 2016-02-12 | 2022-10-21 | ザ ジェネラル ホスピタル コーポレイション | 光コヒ-レンストモグラフィを用いた高速・長深度レンジの撮像装置及び方法 |
WO2017216242A1 (en) | 2016-06-15 | 2017-12-21 | Carl Zeiss Meditec Ag | Efficient sampling of optical coherence tomography data for explicit ranging over extended depth |
CN106770287B (zh) * | 2016-12-07 | 2018-08-28 | 广东工业大学 | 一种单相机平衡型光学相干层析扫描装置及方法 |
DE102017115922C5 (de) * | 2017-07-14 | 2023-03-23 | Precitec Gmbh & Co. Kg | Verfahren und Vorrichtung zur Messung und Einstellung eines Abstands zwischen einem Bearbeitungskopf und einem Werkstück sowie dazugehöriges Verfahren zur Regelung |
JP6404425B2 (ja) * | 2017-09-27 | 2018-10-10 | 株式会社日立エルジーデータストレージ | 光画像計測装置 |
JP7160935B2 (ja) | 2017-11-28 | 2022-10-25 | ジェンテュイティ・リミテッド・ライアビリティ・カンパニー | 撮像システム |
US11280686B2 (en) * | 2018-07-19 | 2022-03-22 | Applied Materials, Inc. | Temperature measurement using etalons |
CN109164048B (zh) * | 2018-09-18 | 2021-01-05 | 天津大学 | 一种对导管偏振敏感光学相干层析成像偏振解调方法 |
US11175126B2 (en) * | 2019-04-08 | 2021-11-16 | Canon U.S.A., Inc. | Automated polarization control |
CN110530609A (zh) * | 2019-08-28 | 2019-12-03 | 中国科学院合肥物质科学研究院 | 利用回音壁模式激光光源测fp透过率曲线的装置和方法 |
CN113888478B (zh) * | 2021-09-15 | 2022-11-11 | 天津大学 | 一种对血管内导管偏振敏感相干层析成像优化去消偏方法 |
WO2023096353A1 (ko) * | 2021-11-25 | 2023-06-01 | 광주과학기술원 | 흡수식 광섬유 기반 이중 광섬유필터 모듈을 이용한 광파장 측정 장치, 이를 구비한 광센서 시스템 및 광측정 방법 |
Family Cites Families (640)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2339754A (en) * | 1941-03-04 | 1944-01-25 | Westinghouse Electric & Mfg Co | Supervisory apparatus |
US3090753A (en) | 1960-08-02 | 1963-05-21 | Exxon Research Engineering Co | Ester oil compositions containing acid anhydride |
GB1257778A (zh) | 1967-12-07 | 1971-12-22 | ||
US3601480A (en) | 1968-07-10 | 1971-08-24 | Physics Int Co | Optical tunnel high-speed camera system |
JPS4932484U (zh) | 1972-06-19 | 1974-03-20 | ||
US3872407A (en) * | 1972-09-01 | 1975-03-18 | Us Navy | Rapidly tunable laser |
JPS584481Y2 (ja) * | 1973-06-23 | 1983-01-26 | オリンパス光学工業株式会社 | ナイシキヨウシヤヘンカンコウガクケイ |
FR2253410A5 (zh) | 1973-12-03 | 1975-06-27 | Inst Nat Sante Rech Med | |
US3941121A (en) | 1974-12-20 | 1976-03-02 | The University Of Cincinnati | Focusing fiber-optic needle endoscope |
US3983507A (en) | 1975-01-06 | 1976-09-28 | Research Corporation | Tunable laser systems and method |
US3973219A (en) | 1975-04-24 | 1976-08-03 | Cornell Research Foundation, Inc. | Very rapidly tuned cw dye laser |
GB1537925A (en) * | 1976-03-04 | 1979-01-10 | Rca Corp | Interferometer to measure small displacements |
US4030831A (en) | 1976-03-22 | 1977-06-21 | The United States Of America As Represented By The Secretary Of The Navy | Phase detector for optical figure sensing |
US4141362A (en) | 1977-05-23 | 1979-02-27 | Richard Wolf Gmbh | Laser endoscope |
US4224929A (en) | 1977-11-08 | 1980-09-30 | Olympus Optical Co., Ltd. | Endoscope with expansible cuff member and operation section |
GB2047894B (en) | 1978-03-09 | 1982-11-03 | Nat Res Dev | Speckle interferometric measurement of small oscillatory movements |
GB2030313A (en) | 1978-06-29 | 1980-04-02 | Wolf Gmbh Richard | Endoscopes |
FR2448728A1 (fr) | 1979-02-07 | 1980-09-05 | Thomson Csf | Dispositif joint tournant pour liaison par conducteurs optiques et systeme comportant un tel dispositif |
US4295738A (en) | 1979-08-30 | 1981-10-20 | United Technologies Corporation | Fiber optic strain sensor |
US4300816A (en) | 1979-08-30 | 1981-11-17 | United Technologies Corporation | Wide band multicore optical fiber |
US4428643A (en) * | 1981-04-08 | 1984-01-31 | Xerox Corporation | Optical scanning system with wavelength shift correction |
US5065331A (en) | 1981-05-18 | 1991-11-12 | Vachon Reginald I | Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies |
GB2106736B (en) | 1981-09-03 | 1985-06-12 | Standard Telephones Cables Ltd | Optical transmission system |
US4479499A (en) | 1982-01-29 | 1984-10-30 | Alfano Robert R | Method and apparatus for detecting the presence of caries in teeth using visible light |
US5302025A (en) | 1982-08-06 | 1994-04-12 | Kleinerman Marcos Y | Optical systems for sensing temperature and other physical parameters |
US4601036A (en) | 1982-09-30 | 1986-07-15 | Honeywell Inc. | Rapidly tunable laser |
HU187188B (en) | 1982-11-25 | 1985-11-28 | Koezponti Elelmiszeripari | Device for generating radiation of controllable spectral structure |
CH663466A5 (fr) * | 1983-09-12 | 1987-12-15 | Battelle Memorial Institute | Procede et dispositif pour determiner la position d'un objet par rapport a une reference. |
US4639999A (en) | 1984-11-02 | 1987-02-03 | Xerox Corporation | High resolution, high efficiency I.R. LED printing array fabrication method |
US4763977A (en) | 1985-01-09 | 1988-08-16 | Canadian Patents And Development Limited-Societe | Optical fiber coupler with tunable coupling ratio and method of making |
EP0590268B1 (en) | 1985-03-22 | 1998-07-01 | Massachusetts Institute Of Technology | Fiber Optic Probe System for Spectrally Diagnosing Tissue |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
DE3610165A1 (de) | 1985-03-27 | 1986-10-02 | Olympus Optical Co., Ltd., Tokio/Tokyo | Optisches abtastmikroskop |
US4607622A (en) | 1985-04-11 | 1986-08-26 | Charles D. Fritch | Fiber optic ocular endoscope |
US4631498A (en) | 1985-04-26 | 1986-12-23 | Hewlett-Packard Company | CW Laser wavemeter/frequency locking technique |
US4650327A (en) * | 1985-10-28 | 1987-03-17 | Oximetrix, Inc. | Optical catheter calibrating assembly |
JPS62188001U (zh) | 1986-05-20 | 1987-11-30 | ||
US5040889A (en) | 1986-05-30 | 1991-08-20 | Pacific Scientific Company | Spectrometer with combined visible and ultraviolet sample illumination |
CA1290019C (en) | 1986-06-20 | 1991-10-01 | Hideo Kuwahara | Dual balanced optical signal receiver |
US4770492A (en) | 1986-10-28 | 1988-09-13 | Spectran Corporation | Pressure or strain sensitive optical fiber |
JPH0824665B2 (ja) | 1986-11-28 | 1996-03-13 | オリンパス光学工業株式会社 | 内視鏡装置 |
US4744656A (en) | 1986-12-08 | 1988-05-17 | Spectramed, Inc. | Disposable calibration boot for optical-type cardiovascular catheter |
JPS63158363A (ja) | 1986-12-22 | 1988-07-01 | Daikin Mfg Co Ltd | エア回転継手のシ−ル装置 |
US4751706A (en) | 1986-12-31 | 1988-06-14 | The United States Of America As Represented By The Secretary Of The Army | Laser for providing rapid sequence of different wavelengths |
US4834111A (en) | 1987-01-12 | 1989-05-30 | The Trustees Of Columbia University In The City Of New York | Heterodyne interferometer |
JP2697822B2 (ja) | 1987-05-25 | 1998-01-14 | オリンパス光学工業株式会社 | 内視鏡対物レンズ |
CA1339426C (en) | 1987-09-01 | 1997-09-02 | Michael R. Layton | Hydrophone demodulator circuit and method |
US5202931A (en) | 1987-10-06 | 1993-04-13 | Cell Analysis Systems, Inc. | Methods and apparatus for the quantitation of nuclear protein |
US4909631A (en) * | 1987-12-18 | 1990-03-20 | Tan Raul Y | Method for film thickness and refractive index determination |
US4890901A (en) * | 1987-12-22 | 1990-01-02 | Hughes Aircraft Company | Color corrector for embedded prisms |
US4892406A (en) * | 1988-01-11 | 1990-01-09 | United Technologies Corporation | Method of and arrangement for measuring vibrations |
FR2626367B1 (fr) | 1988-01-25 | 1990-05-11 | Thomson Csf | Capteur de temperature multipoints a fibre optique |
FR2626383B1 (fr) | 1988-01-27 | 1991-10-25 | Commissariat Energie Atomique | Procede de microscopie optique confocale a balayage et en profondeur de champ etendue et dispositifs pour la mise en oeuvre du procede |
US4925302A (en) | 1988-04-13 | 1990-05-15 | Hewlett-Packard Company | Frequency locking device |
US5730731A (en) * | 1988-04-28 | 1998-03-24 | Thomas J. Fogarty | Pressure-based irrigation accumulator |
US4998972A (en) * | 1988-04-28 | 1991-03-12 | Thomas J. Fogarty | Real time angioscopy imaging system |
US4905169A (en) * | 1988-06-02 | 1990-02-27 | The United States Of America As Represented By The United States Department Of Energy | Method and apparatus for simultaneously measuring a plurality of spectral wavelengths present in electromagnetic radiation |
US5242437A (en) | 1988-06-10 | 1993-09-07 | Trimedyne Laser Systems, Inc. | Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium |
ATE158659T1 (de) | 1988-07-13 | 1997-10-15 | Optiscan Pty Ltd | Confokales abtast-endoskop |
US5214538A (en) | 1988-07-25 | 1993-05-25 | Keymed (Medical And Industrial Equipment) Limited | Optical apparatus |
GB8817672D0 (en) | 1988-07-25 | 1988-09-01 | Sira Ltd | Optical apparatus |
US4868834A (en) | 1988-09-14 | 1989-09-19 | The United States Of America As Represented By The Secretary Of The Army | System for rapidly tuning a low pressure pulsed laser |
DE3833602A1 (de) * | 1988-10-03 | 1990-02-15 | Krupp Gmbh | Spektrometer zur gleichzeitigen intensitaetsmessung in verschiedenen spektralbereichen |
US4940328A (en) | 1988-11-04 | 1990-07-10 | Georgia Tech Research Corporation | Optical sensing apparatus and method |
US4966589A (en) | 1988-11-14 | 1990-10-30 | Hemedix International, Inc. | Intravenous catheter placement device |
WO1990006718A1 (en) | 1988-12-21 | 1990-06-28 | Massachusetts Institute Of Technology | A method for laser induced fluorescence of tissue |
US5046501A (en) | 1989-01-18 | 1991-09-10 | Wayne State University | Atherosclerotic identification |
US5085496A (en) * | 1989-03-31 | 1992-02-04 | Sharp Kabushiki Kaisha | Optical element and optical pickup device comprising it |
US5317389A (en) | 1989-06-12 | 1994-05-31 | California Institute Of Technology | Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography |
US4965599A (en) | 1989-11-13 | 1990-10-23 | Eastman Kodak Company | Scanning apparatus for halftone image screen writing |
US5133035A (en) | 1989-11-14 | 1992-07-21 | Hicks John W | Multifiber endoscope with multiple scanning modes to produce an image free of fixed pattern noise |
US4984888A (en) | 1989-12-13 | 1991-01-15 | Imo Industries, Inc. | Two-dimensional spectrometer |
KR930003307B1 (ko) | 1989-12-14 | 1993-04-24 | 주식회사 금성사 | 입체용 프로젝터 |
US5251009A (en) | 1990-01-22 | 1993-10-05 | Ciba-Geigy Corporation | Interferometric measuring arrangement for refractive index measurements in capillary tubes |
DD293205B5 (de) | 1990-03-05 | 1995-06-29 | Zeiss Carl Jena Gmbh | Lichtleiterfuehrung fuer ein medizinisches Beobachtungsgeraet |
US5039193A (en) | 1990-04-03 | 1991-08-13 | Focal Technologies Incorporated | Fibre optic single mode rotary joint |
US5262644A (en) | 1990-06-29 | 1993-11-16 | Southwest Research Institute | Remote spectroscopy for raman and brillouin scattering |
US5197470A (en) * | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
GB9015793D0 (en) * | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5845639A (en) | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
US5127730A (en) | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
US5305759A (en) * | 1990-09-26 | 1994-04-26 | Olympus Optical Co., Ltd. | Examined body interior information observing apparatus by using photo-pulses controlling gains for depths |
US5241364A (en) | 1990-10-19 | 1993-08-31 | Fuji Photo Film Co., Ltd. | Confocal scanning type of phase contrast microscope and scanning microscope |
US5250186A (en) | 1990-10-23 | 1993-10-05 | Cetus Corporation | HPLC light scattering detector for biopolymers |
US5202745A (en) * | 1990-11-07 | 1993-04-13 | Hewlett-Packard Company | Polarization independent optical coherence-domain reflectometry |
US5275594A (en) * | 1990-11-09 | 1994-01-04 | C. R. Bard, Inc. | Angioplasty system having means for identification of atherosclerotic plaque |
JP3035336B2 (ja) * | 1990-11-27 | 2000-04-24 | 興和株式会社 | 血流測定装置 |
US5228001A (en) | 1991-01-23 | 1993-07-13 | Syracuse University | Optical random access memory |
US5784162A (en) | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US6198532B1 (en) | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
US5293872A (en) * | 1991-04-03 | 1994-03-15 | Alfano Robert R | Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy |
DE69227902T3 (de) | 1991-04-29 | 2010-04-22 | Massachusetts Institute Of Technology, Cambridge | Vorrichtung für optische abbildung und messung |
US5748598A (en) | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US6501551B1 (en) | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6111645A (en) | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US5956355A (en) | 1991-04-29 | 1999-09-21 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US6564087B1 (en) | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US5441053A (en) | 1991-05-03 | 1995-08-15 | University Of Kentucky Research Foundation | Apparatus and method for multiple wavelength of tissue |
US5281811A (en) | 1991-06-17 | 1994-01-25 | Litton Systems, Inc. | Digital wavelength division multiplex optical transducer having an improved decoder |
US5208651A (en) | 1991-07-16 | 1993-05-04 | The Regents Of The University Of California | Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes |
WO1993003672A1 (en) | 1991-08-20 | 1993-03-04 | Redd Douglas C B | Optical histochemical analysis, in vivo detection and real-time guidance for ablation of abnormal tissues using a raman spectroscopic detection system |
DE4128744C1 (zh) * | 1991-08-29 | 1993-04-22 | Siemens Ag, 8000 Muenchen, De | |
US5177488A (en) * | 1991-10-08 | 1993-01-05 | Hughes Aircraft Company | Programmable fiber optic delay line, and radar target simulation system incorporating the same |
DE69218386T2 (de) | 1991-12-30 | 1997-09-04 | Philips Electronics Nv | Optische Einrichtung und mit einer solchen optischen Einrichtung versehenes Gerät zum Abtasten einer Informationsebene |
US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
US5212667A (en) | 1992-02-03 | 1993-05-18 | General Electric Company | Light imaging in a scattering medium, using ultrasonic probing and speckle image differencing |
US5217456A (en) | 1992-02-24 | 1993-06-08 | Pdt Cardiovascular, Inc. | Device and method for intra-vascular optical radial imaging |
US5248876A (en) | 1992-04-21 | 1993-09-28 | International Business Machines Corporation | Tandem linear scanning confocal imaging system with focal volumes at different heights |
US5283795A (en) | 1992-04-21 | 1994-02-01 | Hughes Aircraft Company | Diffraction grating driven linear frequency chirped laser |
US5486701A (en) * | 1992-06-16 | 1996-01-23 | Prometrix Corporation | Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness |
US5411025A (en) | 1992-06-30 | 1995-05-02 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array |
US5716324A (en) | 1992-08-25 | 1998-02-10 | Fuji Photo Film Co., Ltd. | Endoscope with surface and deep portion imaging systems |
US5348003A (en) | 1992-09-03 | 1994-09-20 | Sirraya, Inc. | Method and apparatus for chemical analysis |
EP0587514A1 (en) | 1992-09-11 | 1994-03-16 | Welch Allyn, Inc. | Processor module for video inspection probe |
US5698397A (en) | 1995-06-07 | 1997-12-16 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5772597A (en) | 1992-09-14 | 1998-06-30 | Sextant Medical Corporation | Surgical tool end effector |
EP0595666B1 (fr) | 1992-09-21 | 1999-12-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Sonde et procédé pour déterminer avec précision la vitesse ou le débit d'un milieu liquide |
US5439000A (en) | 1992-11-18 | 1995-08-08 | Spectrascience, Inc. | Method of diagnosing tissue with guidewire |
US5383467A (en) * | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
US5785663A (en) | 1992-12-21 | 1998-07-28 | Artann Corporation | Method and device for mechanical imaging of prostate |
US5400771A (en) * | 1993-01-21 | 1995-03-28 | Pirak; Leon | Endotracheal intubation assembly and related method |
JPH06222242A (ja) | 1993-01-27 | 1994-08-12 | Shin Etsu Chem Co Ltd | 光ファイバカプラおよびその製造方法 |
US5987346A (en) | 1993-02-26 | 1999-11-16 | Benaron; David A. | Device and method for classification of tissue |
US5414509A (en) | 1993-03-08 | 1995-05-09 | Associated Universities, Inc. | Optical pressure/density measuring means |
JP3112595B2 (ja) * | 1993-03-17 | 2000-11-27 | 安藤電気株式会社 | 光周波数シフタを用いる光ファイバ歪位置測定装置 |
FI93781C (fi) | 1993-03-18 | 1995-05-26 | Wallac Oy | Biospesifinen multiparametrinen määritysmenetelmä |
DE4309056B4 (de) | 1993-03-20 | 2006-05-24 | Häusler, Gerd, Prof. Dr. | Verfahren und Vorrichtung zur Ermittlung der Entfernung und Streuintensität von streuenden Punkten |
US5485079A (en) | 1993-03-29 | 1996-01-16 | Matsushita Electric Industrial Co., Ltd. | Magneto-optical element and optical magnetic field sensor |
DE4310209C2 (de) * | 1993-03-29 | 1996-05-30 | Bruker Medizintech | Optische stationäre Bildgebung in stark streuenden Medien |
US5424827A (en) | 1993-04-30 | 1995-06-13 | Litton Systems, Inc. | Optical system and method for eliminating overlap of diffraction spectra |
SE501932C2 (sv) | 1993-04-30 | 1995-06-26 | Ericsson Telefon Ab L M | Anordning och förfarande för dispersionskompensering i ett fiberoptiskt transmissionssystem |
DE4314189C1 (de) * | 1993-04-30 | 1994-11-03 | Bodenseewerk Geraetetech | Vorrichtung zur Untersuchung von Lichtleitfasern aus Glas mittels Heterodyn-Brillouin-Spektroskopie |
US5454807A (en) | 1993-05-14 | 1995-10-03 | Boston Scientific Corporation | Medical treatment of deeply seated tissue using optical radiation |
EP0627643B1 (en) | 1993-06-03 | 1999-05-06 | Hamamatsu Photonics K.K. | Laser scanning optical system using axicon |
JP3234353B2 (ja) | 1993-06-15 | 2001-12-04 | 富士写真フイルム株式会社 | 断層情報読取装置 |
US5840031A (en) | 1993-07-01 | 1998-11-24 | Boston Scientific Corporation | Catheters for imaging, sensing electrical potentials and ablating tissue |
US5995645A (en) | 1993-08-18 | 1999-11-30 | Applied Spectral Imaging Ltd. | Method of cancer cell detection |
US5803082A (en) | 1993-11-09 | 1998-09-08 | Staplevision Inc. | Omnispectramammography |
CZ286103B6 (cs) * | 1993-11-26 | 2000-01-12 | Rokos A Spol., S.R.O. | Způsob měření spektropolarimetrických vlastností opticky aktivních látek a dichrograf k provedení tohoto způsobu |
US5983125A (en) | 1993-12-13 | 1999-11-09 | The Research Foundation Of City College Of New York | Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy |
US5450203A (en) | 1993-12-22 | 1995-09-12 | Electroglas, Inc. | Method and apparatus for determining an objects position, topography and for imaging |
US5411016A (en) | 1994-02-22 | 1995-05-02 | Scimed Life Systems, Inc. | Intravascular balloon catheter for use in combination with an angioscope |
US5590660A (en) * | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
DE4411017C2 (de) | 1994-03-30 | 1995-06-08 | Alexander Dr Knuettel | Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen |
TW275570B (zh) * | 1994-05-05 | 1996-05-11 | Boehringer Mannheim Gmbh | |
DE69531118D1 (de) | 1994-07-14 | 2003-07-24 | Washington Res Foundation Seat | Vorrichtung zum nachweis der barrett metaplasie in der speiseröhre |
US5459325A (en) | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US6159445A (en) | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
CA2172284C (en) | 1994-08-08 | 1999-09-28 | Richard J. Mammone | Processing of keratoscopic images using local spatial phase |
DE69528024T2 (de) | 1994-08-18 | 2003-10-09 | Zeiss Carl | Mit optischer Kohärenz-Tomographie gesteuerter chirurgischer Apparat |
US5491524A (en) * | 1994-10-05 | 1996-02-13 | Carl Zeiss, Inc. | Optical coherence tomography corneal mapping apparatus |
US5740808A (en) | 1996-10-28 | 1998-04-21 | Ep Technologies, Inc | Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions |
US5817144A (en) | 1994-10-25 | 1998-10-06 | Latis, Inc. | Method for contemporaneous application OF laser energy and localized pharmacologic therapy |
US6033721A (en) * | 1994-10-26 | 2000-03-07 | Revise, Inc. | Image-based three-axis positioner for laser direct write microchemical reaction |
JPH08136345A (ja) | 1994-11-10 | 1996-05-31 | Anritsu Corp | 複単色計 |
JPH08160129A (ja) | 1994-12-05 | 1996-06-21 | Uniden Corp | 速度検出装置 |
US5566267A (en) | 1994-12-15 | 1996-10-15 | Ceram Optec Industries Inc. | Flat surfaced optical fibers and diode laser medical delivery devices |
US5600486A (en) * | 1995-01-30 | 1997-02-04 | Lockheed Missiles And Space Company, Inc. | Color separation microlens |
US5648848A (en) | 1995-02-01 | 1997-07-15 | Nikon Precision, Inc. | Beam delivery apparatus and method for interferometry using rotatable polarization chucks |
DE19506484C2 (de) | 1995-02-24 | 1999-09-16 | Stiftung Fuer Lasertechnologie | Verfahren und Vorrichtung zur selektiven nichtinvasiven Lasermyographie (LMG) |
RU2100787C1 (ru) * | 1995-03-01 | 1997-12-27 | Геликонов Валентин Михайлович | Оптоволоконный интерферометр и оптоволоконный пьезоэлектрический преобразователь |
WO1996028212A1 (en) | 1995-03-09 | 1996-09-19 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US5868731A (en) | 1996-03-04 | 1999-02-09 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US5526338A (en) | 1995-03-10 | 1996-06-11 | Yeda Research & Development Co. Ltd. | Method and apparatus for storage and retrieval with multilayer optical disks |
US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5735276A (en) * | 1995-03-21 | 1998-04-07 | Lemelson; Jerome | Method and apparatus for scanning and evaluating matter |
JP3945820B2 (ja) | 1995-03-24 | 2007-07-18 | オプティスキャン ピーティーワイ リミテッド | 可変近共焦点制御手段を備えた光ファイバ共焦点像形成装置 |
JPH08304229A (ja) | 1995-05-09 | 1996-11-22 | Ricoh Co Ltd | 光学素子の屈折率分布の測定方法および装置 |
US5565983A (en) | 1995-05-26 | 1996-10-15 | The Perkin-Elmer Corporation | Optical spectrometer for detecting spectra in separate ranges |
US5785651A (en) | 1995-06-07 | 1998-07-28 | Keravision, Inc. | Distance measuring confocal microscope |
US5621830A (en) | 1995-06-07 | 1997-04-15 | Smith & Nephew Dyonics Inc. | Rotatable fiber optic joint |
WO1997001167A1 (en) | 1995-06-21 | 1997-01-09 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
ATA107495A (de) | 1995-06-23 | 1996-06-15 | Fercher Adolf Friedrich Dr | Kohärenz-biometrie und -tomographie mit dynamischem kohärentem fokus |
US5829439A (en) | 1995-06-28 | 1998-11-03 | Hitachi Medical Corporation | Needle-like ultrasonic probe for ultrasonic diagnosis apparatus, method of producing same, and ultrasonic diagnosis apparatus using same |
US6104945A (en) | 1995-08-01 | 2000-08-15 | Medispectra, Inc. | Spectral volume microprobe arrays |
AU1130797A (en) * | 1995-08-24 | 1997-03-19 | Purdue Research Foundation | Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media |
US6016197A (en) * | 1995-08-25 | 2000-01-18 | Ceramoptec Industries Inc. | Compact, all-optical spectrum analyzer for chemical and biological fiber optic sensors |
FR2738343B1 (fr) | 1995-08-30 | 1997-10-24 | Cohen Sabban Joseph | Dispositif de microstratigraphie optique |
AU709432B2 (en) | 1995-09-20 | 1999-08-26 | California Institute Of Technology | Detecting thermal discrepancies in vessel walls |
US6763261B2 (en) | 1995-09-20 | 2004-07-13 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
US5742419A (en) | 1995-11-07 | 1998-04-21 | The Board Of Trustees Of The Leland Stanford Junior Universtiy | Miniature scanning confocal microscope |
DE19542955C2 (de) | 1995-11-17 | 1999-02-18 | Schwind Gmbh & Co Kg Herbert | Endoskop |
US5719399A (en) * | 1995-12-18 | 1998-02-17 | The Research Foundation Of City College Of New York | Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough |
JP3699761B2 (ja) | 1995-12-26 | 2005-09-28 | オリンパス株式会社 | 落射蛍光顕微鏡 |
US5748318A (en) | 1996-01-23 | 1998-05-05 | Brown University Research Foundation | Optical stress generator and detector |
US5840023A (en) | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
US5642194A (en) | 1996-02-05 | 1997-06-24 | The Regents Of The University Of California | White light velocity interferometer |
US5862273A (en) | 1996-02-23 | 1999-01-19 | Kaiser Optical Systems, Inc. | Fiber optic probe with integral optical filtering |
US5843000A (en) | 1996-05-07 | 1998-12-01 | The General Hospital Corporation | Optical biopsy forceps and method of diagnosing tissue |
ATA84696A (de) * | 1996-05-14 | 1998-03-15 | Adolf Friedrich Dr Fercher | Verfahren und anordnungen zur kontrastanhebung in der optischen kohärenztomographie |
US6020963A (en) * | 1996-06-04 | 2000-02-01 | Northeastern University | Optical quadrature Interferometer |
US5795295A (en) | 1996-06-25 | 1998-08-18 | Carl Zeiss, Inc. | OCT-assisted surgical microscope with multi-coordinate manipulator |
US5842995A (en) | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
US6296608B1 (en) | 1996-07-08 | 2001-10-02 | Boston Scientific Corporation | Diagnosing and performing interventional procedures on tissue in vivo |
US6245026B1 (en) | 1996-07-29 | 2001-06-12 | Farallon Medsystems, Inc. | Thermography catheter |
US5840075A (en) | 1996-08-23 | 1998-11-24 | Eclipse Surgical Technologies, Inc. | Dual laser device for transmyocardial revascularization procedures |
US6396941B1 (en) | 1996-08-23 | 2002-05-28 | Bacus Research Laboratories, Inc. | Method and apparatus for internet, intranet, and local viewing of virtual microscope slides |
US6544193B2 (en) | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
JPH1090117A (ja) | 1996-09-11 | 1998-04-10 | Ricoh Co Ltd | 屈折率分布の測定方法及び装置 |
JPH1090603A (ja) | 1996-09-18 | 1998-04-10 | Olympus Optical Co Ltd | 内視鏡光学系 |
US5801831A (en) | 1996-09-20 | 1998-09-01 | Institute For Space And Terrestrial Science | Fabry-Perot spectrometer for detecting a spatially varying spectral signature of an extended source |
US6249349B1 (en) | 1996-09-27 | 2001-06-19 | Vincent Lauer | Microscope generating a three-dimensional representation of an object |
US5843052A (en) | 1996-10-04 | 1998-12-01 | Benja-Athon; Anuthep | Irrigation kit for application of fluids and chemicals for cleansing and sterilizing wounds |
US5752518A (en) | 1996-10-28 | 1998-05-19 | Ep Technologies, Inc. | Systems and methods for visualizing interior regions of the body |
US5904651A (en) | 1996-10-28 | 1999-05-18 | Ep Technologies, Inc. | Systems and methods for visualizing tissue during diagnostic or therapeutic procedures |
US6044288A (en) * | 1996-11-08 | 2000-03-28 | Imaging Diagnostics Systems, Inc. | Apparatus and method for determining the perimeter of the surface of an object being scanned |
US5872879A (en) | 1996-11-25 | 1999-02-16 | Boston Scientific Corporation | Rotatable connecting optical fibers |
US6517532B1 (en) * | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6437867B2 (en) | 1996-12-04 | 2002-08-20 | The Research Foundation Of The City University Of New York | Performing selected optical measurements with optical coherence domain reflectometry |
US6249630B1 (en) | 1996-12-13 | 2001-06-19 | Imra America, Inc. | Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power |
US5871449A (en) * | 1996-12-27 | 1999-02-16 | Brown; David Lloyd | Device and method for locating inflamed plaque in an artery |
EP1018045A4 (en) | 1996-12-31 | 2001-01-31 | Corning Inc | OPTICAL COUPLERS WITH MULTI-LAYER FIBERS |
US5991697A (en) | 1996-12-31 | 1999-11-23 | The Regents Of The University Of California | Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media |
US5760901A (en) | 1997-01-28 | 1998-06-02 | Zetetic Institute | Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation |
JP3213250B2 (ja) | 1997-01-29 | 2001-10-02 | 株式会社生体光情報研究所 | 光計測装置 |
US5801826A (en) | 1997-02-18 | 1998-09-01 | Williams Family Trust B | Spectrometric device and method for recognizing atomic and molecular signatures |
US5836877A (en) | 1997-02-24 | 1998-11-17 | Lucid Inc | System for facilitating pathological examination of a lesion in tissue |
US5968064A (en) | 1997-02-28 | 1999-10-19 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
US6120516A (en) | 1997-02-28 | 2000-09-19 | Lumend, Inc. | Method for treating vascular occlusion |
US6010449A (en) * | 1997-02-28 | 2000-01-04 | Lumend, Inc. | Intravascular catheter system for treating a vascular occlusion |
WO1998038907A1 (en) | 1997-03-06 | 1998-09-11 | Massachusetts Institute Of Technology | Instrument for optically scanning of living tissue |
AU6604998A (en) * | 1997-03-13 | 1998-09-29 | Biomax Technologies, Inc. | Methods and apparatus for detecting the rejection of transplanted tissue |
US6078047A (en) | 1997-03-14 | 2000-06-20 | Lucent Technologies Inc. | Method and apparatus for terahertz tomographic imaging |
US5994690A (en) | 1997-03-17 | 1999-11-30 | Kulkarni; Manish D. | Image enhancement in optical coherence tomography using deconvolution |
JPH10267830A (ja) | 1997-03-26 | 1998-10-09 | Kowa Co | 光学測定装置 |
JPH10267631A (ja) | 1997-03-26 | 1998-10-09 | Kowa Co | 光学測定装置 |
GB9707414D0 (en) | 1997-04-11 | 1997-05-28 | Imperial College | Anatomical probe |
JP2001526650A (ja) | 1997-04-29 | 2001-12-18 | ニユコメド・イメージング・アクシエセルカペト | 光画像造影剤 |
US6117128A (en) | 1997-04-30 | 2000-09-12 | Kenton W. Gregory | Energy delivery catheter and method for the use thereof |
US5887009A (en) * | 1997-05-22 | 1999-03-23 | Optical Biopsy Technologies, Inc. | Confocal optical scanning system employing a fiber laser |
US6006128A (en) | 1997-06-02 | 1999-12-21 | Izatt; Joseph A. | Doppler flow imaging using optical coherence tomography |
US6002480A (en) | 1997-06-02 | 1999-12-14 | Izatt; Joseph A. | Depth-resolved spectroscopic optical coherence tomography |
US6208415B1 (en) * | 1997-06-12 | 2001-03-27 | The Regents Of The University Of California | Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography |
WO1998058588A1 (en) | 1997-06-23 | 1998-12-30 | Focus Surgery, Inc. | Methods and devices for providing acoustic hemostasis |
US5920390A (en) | 1997-06-26 | 1999-07-06 | University Of North Carolina | Fiberoptic interferometer and associated method for analyzing tissue |
US6048349A (en) | 1997-07-09 | 2000-04-11 | Intraluminal Therapeutics, Inc. | Systems and methods for guiding a medical instrument through a body |
US6058352A (en) | 1997-07-25 | 2000-05-02 | Physical Optics Corporation | Accurate tissue injury assessment using hybrid neural network analysis |
US5921926A (en) | 1997-07-28 | 1999-07-13 | University Of Central Florida | Three dimensional optical imaging colposcopy |
US6014214A (en) | 1997-08-21 | 2000-01-11 | Li; Ming-Chiang | High speed inspection of a sample using coherence processing of scattered superbroad radiation |
US5892583A (en) * | 1997-08-21 | 1999-04-06 | Li; Ming-Chiang | High speed inspection of a sample using superbroad radiation coherent interferometer |
US6069698A (en) | 1997-08-28 | 2000-05-30 | Olympus Optical Co., Ltd. | Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object |
US6297018B1 (en) | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
US5920373A (en) | 1997-09-24 | 1999-07-06 | Heidelberg Engineering Optische Messysteme Gmbh | Method and apparatus for determining optical characteristics of a cornea |
US6193676B1 (en) * | 1997-10-03 | 2001-02-27 | Intraluminal Therapeutics, Inc. | Guide wire assembly |
US5951482A (en) | 1997-10-03 | 1999-09-14 | Intraluminal Therapeutics, Inc. | Assemblies and methods for advancing a guide wire through body tissue |
US6091984A (en) | 1997-10-10 | 2000-07-18 | Massachusetts Institute Of Technology | Measuring tissue morphology |
US5955737A (en) | 1997-10-27 | 1999-09-21 | Systems & Processes Engineering Corporation | Chemometric analysis for extraction of individual fluorescence spectrum and lifetimes from a target mixture |
US6052186A (en) | 1997-11-05 | 2000-04-18 | Excel Precision, Inc. | Dual laser system for extended heterodyne interferometry |
US6134010A (en) | 1997-11-07 | 2000-10-17 | Lucid, Inc. | Imaging system using polarization effects to enhance image quality |
US6037579A (en) | 1997-11-13 | 2000-03-14 | Biophotonics Information Laboratories, Ltd. | Optical interferometer employing multiple detectors to detect spatially distorted wavefront in imaging of scattering media |
US6107048A (en) | 1997-11-20 | 2000-08-22 | Medical College Of Georgia Research Institute, Inc. | Method of detecting and grading dysplasia in epithelial tissue |
EP1103041B1 (en) | 1998-01-28 | 2016-03-23 | Immersion Medical, Inc. | Interface device and method for interfacing instruments to medical procedure simulation system |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
US6831781B2 (en) | 1998-02-26 | 2004-12-14 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy |
US6134033A (en) | 1998-02-26 | 2000-10-17 | Tyco Submarine Systems Ltd. | Method and apparatus for improving spectral efficiency in wavelength division multiplexed transmission systems |
US6341036B1 (en) * | 1998-02-26 | 2002-01-22 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding |
US6048742A (en) | 1998-02-26 | 2000-04-11 | The United States Of America As Represented By The Secretary Of The Air Force | Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers |
RU2148378C1 (ru) | 1998-03-06 | 2000-05-10 | Геликонов Валентин Михайлович | Устройство для оптической когерентной томографии, оптоволоконное сканирующее устройство и способ диагностики биоткани in vivo |
US6066102A (en) | 1998-03-09 | 2000-05-23 | Spectrascience, Inc. | Optical biopsy forceps system and method of diagnosing tissue |
US6174291B1 (en) * | 1998-03-09 | 2001-01-16 | Spectrascience, Inc. | Optical biopsy system and methods for tissue diagnosis |
US6151522A (en) | 1998-03-16 | 2000-11-21 | The Research Foundation Of Cuny | Method and system for examining biological materials using low power CW excitation raman spectroscopy |
US6384915B1 (en) | 1998-03-30 | 2002-05-07 | The Regents Of The University Of California | Catheter guided by optical coherence domain reflectometry |
US6175669B1 (en) * | 1998-03-30 | 2001-01-16 | The Regents Of The Universtiy Of California | Optical coherence domain reflectometry guidewire |
DE19814057B4 (de) | 1998-03-30 | 2009-01-02 | Carl Zeiss Meditec Ag | Anordnung zur optischen Kohärenztomographie und Kohärenztopographie |
US5975699A (en) | 1998-04-29 | 1999-11-02 | Carl Zeiss, Inc. | Method and apparatus for simultaneously measuring the length and refractive error of an eye |
AU3781799A (en) | 1998-05-01 | 1999-11-23 | Board Of Regents, The University Of Texas System | Method and apparatus for subsurface imaging |
US6996549B2 (en) | 1998-05-01 | 2006-02-07 | Health Discovery Corporation | Computer-aided image analysis |
JPH11326826A (ja) | 1998-05-13 | 1999-11-26 | Sony Corp | 照明方法及び照明装置 |
US6053613A (en) | 1998-05-15 | 2000-04-25 | Carl Zeiss, Inc. | Optical coherence tomography with new interferometer |
FR2778838A1 (fr) | 1998-05-19 | 1999-11-26 | Koninkl Philips Electronics Nv | Procede de detection de variations d'elasticite et appareil echographique pour mettre en oeuvre ce procede |
US5995223A (en) | 1998-06-01 | 1999-11-30 | Power; Joan Fleurette | Apparatus for rapid phase imaging interferometry and method therefor |
JPH11352409A (ja) | 1998-06-05 | 1999-12-24 | Olympus Optical Co Ltd | 蛍光検出装置 |
US6549801B1 (en) | 1998-06-11 | 2003-04-15 | The Regents Of The University Of California | Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity |
WO2000003651A1 (en) | 1998-07-15 | 2000-01-27 | Corazon Technologies, Inc. | Methods and devices for reducing the mineral content of vascular calcified lesions |
US6166373A (en) | 1998-07-21 | 2000-12-26 | The Institute For Technology Development | Focal plane scanner with reciprocating spatial window |
JP2000046729A (ja) | 1998-07-31 | 2000-02-18 | Takahisa Mitsui | 波長分散を用いた高速光断層像計測装置および計測方法 |
US20040140130A1 (en) | 1998-08-31 | 2004-07-22 | Halliburton Energy Services, Inc., A Delaware Corporation | Roller-cone bits, systems, drilling methods, and design methods with optimization of tooth orientation |
US8024027B2 (en) | 1998-09-03 | 2011-09-20 | Hyperspectral Imaging, Inc. | Infrared endoscopic balloon probes |
US6741884B1 (en) | 1998-09-03 | 2004-05-25 | Hypermed, Inc. | Infrared endoscopic balloon probes |
AU6139199A (en) | 1998-09-11 | 2000-04-03 | Spectrx, Inc. | Multi-modal optical tissue diagnostic system |
AU6417599A (en) | 1998-10-08 | 2000-04-26 | University Of Kentucky Research Foundation, The | Methods and apparatus for (in vivo) identification and characterization of vulnerable atherosclerotic plaques |
JP2000121961A (ja) | 1998-10-13 | 2000-04-28 | Olympus Optical Co Ltd | 共焦点光走査プローブシステム |
US6274871B1 (en) | 1998-10-22 | 2001-08-14 | Vysis, Inc. | Method and system for performing infrared study on a biological sample |
US6324419B1 (en) | 1998-10-27 | 2001-11-27 | Nejat Guzelsu | Apparatus and method for non-invasive measurement of stretch |
JP2000126116A (ja) | 1998-10-28 | 2000-05-09 | Olympus Optical Co Ltd | 光診断システム |
US6524249B2 (en) | 1998-11-11 | 2003-02-25 | Spentech, Inc. | Doppler ultrasound method and apparatus for monitoring blood flow and detecting emboli |
US6516014B1 (en) | 1998-11-13 | 2003-02-04 | The Research And Development Institute, Inc. | Programmable frequency reference for laser frequency stabilization, and arbitrary optical clock generator, using persistent spectral hole burning |
EP1002497B1 (en) | 1998-11-20 | 2006-07-26 | Fuji Photo Film Co., Ltd. | Blood vessel imaging system |
US5975697A (en) | 1998-11-25 | 1999-11-02 | Oti Ophthalmic Technologies, Inc. | Optical mapping apparatus with adjustable depth resolution |
US6352502B1 (en) | 1998-12-03 | 2002-03-05 | Lightouch Medical, Inc. | Methods for obtaining enhanced spectroscopic information from living tissue, noninvasive assessment of skin condition and detection of skin abnormalities |
RU2149464C1 (ru) | 1999-01-19 | 2000-05-20 | Таганрогский государственный радиотехнический университет | Динамическое запоминающее устройство радиосигналов |
US6191862B1 (en) * | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6445944B1 (en) | 1999-02-01 | 2002-09-03 | Scimed Life Systems | Medical scanning system and related method of scanning |
US6615072B1 (en) | 1999-02-04 | 2003-09-02 | Olympus Optical Co., Ltd. | Optical imaging device |
US6185271B1 (en) * | 1999-02-16 | 2001-02-06 | Richard Estyn Kinsinger | Helical computed tomography with feedback scan control |
DE19908883A1 (de) | 1999-03-02 | 2000-09-07 | Rainer Heintzmann | Verfahren zur Erhöhung der Auflösung optischer Abbildung |
US20070048818A1 (en) * | 1999-03-12 | 2007-03-01 | Human Genome Sciences, Inc. | Human secreted proteins |
EP1181598A4 (en) | 1999-03-29 | 2004-05-12 | Scimed Life Systems Inc | SINGLE-MODE FIBER OPTIC COUPLING SYSTEMS |
US6859275B2 (en) | 1999-04-09 | 2005-02-22 | Plain Sight Systems, Inc. | System and method for encoded spatio-spectral information processing |
US6264610B1 (en) | 1999-05-05 | 2001-07-24 | The University Of Connecticut | Combined ultrasound and near infrared diffused light imaging system |
US6353693B1 (en) * | 1999-05-31 | 2002-03-05 | Sanyo Electric Co., Ltd. | Optical communication device and slip ring unit for an electronic component-mounting apparatus |
JP2001004447A (ja) | 1999-06-23 | 2001-01-12 | Yokogawa Electric Corp | 分光器 |
US6611833B1 (en) | 1999-06-23 | 2003-08-26 | Tissueinformatics, Inc. | Methods for profiling and classifying tissue using a database that includes indices representative of a tissue population |
US6993170B2 (en) | 1999-06-23 | 2006-01-31 | Icoria, Inc. | Method for quantitative analysis of blood vessel structure |
US6208887B1 (en) * | 1999-06-24 | 2001-03-27 | Richard H. Clarke | Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions |
GB9915082D0 (en) | 1999-06-28 | 1999-08-25 | Univ London | Optical fibre probe |
US6359692B1 (en) * | 1999-07-09 | 2002-03-19 | Zygo Corporation | Method and system for profiling objects having multiple reflective surfaces using wavelength-tuning phase-shifting interferometry |
AU6093400A (en) | 1999-07-13 | 2001-01-30 | Chromavision Medical Systems, Inc. | Automated detection of objects in a biological sample |
DE60032637T2 (de) | 1999-07-30 | 2007-11-15 | Ceramoptec Gmbh | Medizinisches diodenlasersystem mit zwei wellenlängen |
WO2001008561A1 (en) | 1999-07-30 | 2001-02-08 | Boston Scientific Limited | Rotational and translational drive coupling for catheter assembly |
JP2001046321A (ja) | 1999-08-09 | 2001-02-20 | Asahi Optical Co Ltd | 内視鏡装置 |
US6445939B1 (en) | 1999-08-09 | 2002-09-03 | Lightlab Imaging, Llc | Ultra-small optical probes, imaging optics, and methods for using same |
US6725073B1 (en) | 1999-08-17 | 2004-04-20 | Board Of Regents, The University Of Texas System | Methods for noninvasive analyte sensing |
JP3869589B2 (ja) | 1999-09-02 | 2007-01-17 | ペンタックス株式会社 | ファイババンドル及び内視鏡装置 |
US6687010B1 (en) * | 1999-09-09 | 2004-02-03 | Olympus Corporation | Rapid depth scanning optical imaging device |
JP4464519B2 (ja) | 2000-03-21 | 2010-05-19 | オリンパス株式会社 | 光イメージング装置 |
US6198956B1 (en) * | 1999-09-30 | 2001-03-06 | Oti Ophthalmic Technologies Inc. | High speed sector scanning apparatus having digital electronic control |
JP2001174744A (ja) | 1999-10-06 | 2001-06-29 | Olympus Optical Co Ltd | 光走査プローブ装置 |
US6393312B1 (en) | 1999-10-13 | 2002-05-21 | C. R. Bard, Inc. | Connector for coupling an optical fiber tissue localization device to a light source |
US6308092B1 (en) | 1999-10-13 | 2001-10-23 | C. R. Bard Inc. | Optical fiber tissue localization device |
AU1182401A (en) | 1999-10-15 | 2001-04-23 | Cellavision Ab | Microscope and method for manufacturing a composite image with a high resolution |
US6538817B1 (en) * | 1999-10-25 | 2003-03-25 | Aculight Corporation | Method and apparatus for optical coherence tomography with a multispectral laser source |
JP2001125009A (ja) | 1999-10-28 | 2001-05-11 | Asahi Optical Co Ltd | 内視鏡装置 |
IL132687A0 (en) | 1999-11-01 | 2001-03-19 | Keren Mechkarim Ichilov Pnimit | System and method for evaluating body fluid samples |
CA2392228A1 (en) | 1999-11-19 | 2001-05-25 | Ming Xiao | Compact spectrofluorometer |
EP1232377B1 (de) | 1999-11-24 | 2004-03-31 | Haag-Streit Ag | Verfahren und vorrichtung zur messung optischer eigenschaften wenigstens zweier voneinander distanzierter bereiche in einem transparenten und/oder diffusiven gegenstand |
US7236637B2 (en) | 1999-11-24 | 2007-06-26 | Ge Medical Systems Information Technologies, Inc. | Method and apparatus for transmission and display of a compressed digitized image |
EP1240476A1 (en) | 1999-12-09 | 2002-09-18 | Oti Ophthalmic Technologies Inc. | Optical mapping apparatus with adjustable depth resolution |
JP2001174404A (ja) | 1999-12-15 | 2001-06-29 | Takahisa Mitsui | 光断層像計測装置および計測方法 |
US6738144B1 (en) | 1999-12-17 | 2004-05-18 | University Of Central Florida | Non-invasive method and low-coherence apparatus system analysis and process control |
US6680780B1 (en) * | 1999-12-23 | 2004-01-20 | Agere Systems, Inc. | Interferometric probe stabilization relative to subject movement |
US6445485B1 (en) | 2000-01-21 | 2002-09-03 | At&T Corp. | Micro-machine polarization-state controller |
EP1251779A1 (en) | 2000-01-27 | 2002-10-30 | National Research Council of Canada | Visible-near infrared spectroscopy in burn injury assessment |
JP3660185B2 (ja) | 2000-02-07 | 2005-06-15 | 独立行政法人科学技術振興機構 | 断層像形成方法及びそのための装置 |
US6475210B1 (en) | 2000-02-11 | 2002-11-05 | Medventure Technology Corp | Light treatment of vulnerable atherosclerosis plaque |
US6556305B1 (en) | 2000-02-17 | 2003-04-29 | Veeco Instruments, Inc. | Pulsed source scanning interferometer |
US6618143B2 (en) | 2000-02-18 | 2003-09-09 | Idexx Laboratories, Inc. | High numerical aperture flow cytometer and method of using same |
US6751490B2 (en) | 2000-03-01 | 2004-06-15 | The Board Of Regents Of The University Of Texas System | Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit |
WO2001072215A1 (en) | 2000-03-28 | 2001-10-04 | Board Of Regents, The University Of Texas System | Enhancing contrast in biological imaging |
US6687013B2 (en) | 2000-03-28 | 2004-02-03 | Hitachi, Ltd. | Laser interferometer displacement measuring system, exposure apparatus, and electron beam lithography apparatus |
US6567585B2 (en) | 2000-04-04 | 2003-05-20 | Optiscan Pty Ltd | Z sharpening for fibre confocal microscopes |
US6692430B2 (en) | 2000-04-10 | 2004-02-17 | C2Cure Inc. | Intra vascular imaging apparatus |
EP1299057A2 (en) | 2000-04-27 | 2003-04-09 | Iridex Corporation | Method and apparatus for real-time detection, control and recording of sub-clinical therapeutic laser lesions during ocular laser photocoagulation |
US6711283B1 (en) | 2000-05-03 | 2004-03-23 | Aperio Technologies, Inc. | Fully automatic rapid microscope slide scanner |
AU2001259435A1 (en) | 2000-05-03 | 2001-11-12 | Stephen T Flock | Optical imaging of subsurface anatomical structures and biomolecules |
US6301048B1 (en) | 2000-05-19 | 2001-10-09 | Avanex Corporation | Tunable chromatic dispersion and dispersion slope compensator utilizing a virtually imaged phased array |
US6441959B1 (en) | 2000-05-19 | 2002-08-27 | Avanex Corporation | Method and system for testing a tunable chromatic dispersion, dispersion slope, and polarization mode dispersion compensator utilizing a virtually imaged phased array |
US6560259B1 (en) | 2000-05-31 | 2003-05-06 | Applied Optoelectronics, Inc. | Spatially coherent surface-emitting, grating coupled quantum cascade laser with unstable resonance cavity |
US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
JP4460117B2 (ja) | 2000-06-29 | 2010-05-12 | 独立行政法人理化学研究所 | グリズム |
JP2002035005A (ja) | 2000-07-21 | 2002-02-05 | Olympus Optical Co Ltd | 治療装置 |
US6757467B1 (en) | 2000-07-25 | 2004-06-29 | Optical Air Data Systems, Lp | Optical fiber system |
US6441356B1 (en) | 2000-07-28 | 2002-08-27 | Optical Biopsy Technologies | Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes |
US6882432B2 (en) * | 2000-08-08 | 2005-04-19 | Zygo Corporation | Frequency transform phase shifting interferometry |
WO2002014944A1 (en) | 2000-08-11 | 2002-02-21 | Crystal Fibre A/S | Optical wavelength converter |
US7625335B2 (en) | 2000-08-25 | 2009-12-01 | 3Shape Aps | Method and apparatus for three-dimensional optical scanning of interior surfaces |
DE10042840A1 (de) | 2000-08-30 | 2002-03-14 | Leica Microsystems | Vorrichtung und Verfahren zur Anregung von Fluoreszenzmikroskopmarkern bei der Mehrphotonen-Rastermikroskopie |
WO2002021170A1 (en) | 2000-09-05 | 2002-03-14 | Arroyo Optics, Inc. | System and method for fabricating components of precise optical path length |
JP2002095663A (ja) | 2000-09-26 | 2002-04-02 | Fuji Photo Film Co Ltd | センチネルリンパ節光断層画像取得方法および装置 |
JP2002113017A (ja) | 2000-10-05 | 2002-04-16 | Fuji Photo Film Co Ltd | レーザ治療装置 |
AU2002230842A1 (en) | 2000-10-30 | 2002-05-15 | The General Hospital Corporation | Optical methods and systems for tissue analysis |
AU1210502A (en) | 2000-10-31 | 2002-05-15 | Forskningsct Riso | Optical amplification in coherent optical frequency modulated continuous wave reflectometry |
JP3842101B2 (ja) | 2000-10-31 | 2006-11-08 | 富士写真フイルム株式会社 | 内視鏡装置 |
US6687036B2 (en) * | 2000-11-03 | 2004-02-03 | Nuonics, Inc. | Multiplexed optical scanner technology |
JP2002148185A (ja) | 2000-11-08 | 2002-05-22 | Fuji Photo Film Co Ltd | Oct装置 |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
AU2002216035A1 (en) | 2000-11-13 | 2002-05-21 | Gnothis Holding Sa | Detection of nucleic acid polymorphisms |
US6665075B2 (en) | 2000-11-14 | 2003-12-16 | Wm. Marshurice University | Interferometric imaging system and method |
DE10057539B4 (de) | 2000-11-20 | 2008-06-12 | Robert Bosch Gmbh | Interferometrische Messvorrichtung |
US6558324B1 (en) | 2000-11-22 | 2003-05-06 | Siemens Medical Solutions, Inc., Usa | System and method for strain image display |
US6856712B2 (en) | 2000-11-27 | 2005-02-15 | University Of Washington | Micro-fabricated optical waveguide for use in scanning fiber displays and scanned fiber image acquisition |
US7027633B2 (en) | 2000-11-30 | 2006-04-11 | Foran David J | Collaborative diagnostic systems |
JP4786027B2 (ja) | 2000-12-08 | 2011-10-05 | オリンパス株式会社 | 光学系及び光学装置 |
US6687007B1 (en) * | 2000-12-14 | 2004-02-03 | Kestrel Corporation | Common path interferometer for spectral image generation |
US6501878B2 (en) | 2000-12-14 | 2002-12-31 | Nortel Networks Limited | Optical fiber termination |
WO2002054046A1 (fr) | 2000-12-28 | 2002-07-11 | Dmitri Olegovich Lapotko | Procede et dispositif d'examen phototermique d'irregularites microscopique |
CN101194856A (zh) | 2000-12-28 | 2008-06-11 | 帕洛玛医疗技术有限公司 | 用于皮肤的emr治疗处理的方法和装置 |
US6515752B2 (en) | 2000-12-28 | 2003-02-04 | Coretek, Inc. | Wavelength monitoring system |
EP1221581A1 (en) | 2001-01-04 | 2002-07-10 | Universität Stuttgart | Interferometer |
JP2002205434A (ja) | 2001-01-10 | 2002-07-23 | Seiko Epson Corp | 画像出力装置及びプリンティングシステム |
WO2002054948A1 (en) | 2001-01-11 | 2002-07-18 | The Johns Hopkins University | Assessment of tooth structure using laser based ultrasonics |
US7177491B2 (en) | 2001-01-12 | 2007-02-13 | Board Of Regents The University Of Texas System | Fiber-based optical low coherence tomography |
JP3628615B2 (ja) | 2001-01-16 | 2005-03-16 | 独立行政法人科学技術振興機構 | ヘテロダインビート画像同期測定装置 |
US6697652B2 (en) | 2001-01-19 | 2004-02-24 | Massachusetts Institute Of Technology | Fluorescence, reflectance and light scattering spectroscopy for measuring tissue |
EP1358443A2 (en) | 2001-01-22 | 2003-11-05 | Jonathan E. Roth | Method and apparatus for polarization-sensitive optical coherence tomography |
US7973936B2 (en) | 2001-01-30 | 2011-07-05 | Board Of Trustees Of Michigan State University | Control system and apparatus for use with ultra-fast laser |
US20020140942A1 (en) | 2001-02-17 | 2002-10-03 | Fee Michale Sean | Acousto-optic monitoring and imaging in a depth sensitive manner |
GB0104378D0 (en) | 2001-02-22 | 2001-04-11 | Expro North Sea Ltd | Improved tubing coupling |
US6654127B2 (en) | 2001-03-01 | 2003-11-25 | Carl Zeiss Ophthalmic Systems, Inc. | Optical delay line |
US6721094B1 (en) * | 2001-03-05 | 2004-04-13 | Sandia Corporation | Long working distance interference microscope |
US7244232B2 (en) | 2001-03-07 | 2007-07-17 | Biomed Solutions, Llc | Process for identifying cancerous and/or metastatic cells of a living organism |
IL142773A (en) | 2001-03-08 | 2007-10-31 | Xtellus Inc | Fiber optic damper |
JP2002263055A (ja) | 2001-03-12 | 2002-09-17 | Olympus Optical Co Ltd | 内視鏡先端フード |
JP4559650B2 (ja) * | 2001-03-22 | 2010-10-13 | シチズンホールディングス株式会社 | 旋光度測定装置及び旋光度測定方法 |
US6563995B2 (en) | 2001-04-02 | 2003-05-13 | Lightwave Electronics | Optical wavelength filtering apparatus with depressed-index claddings |
US6552796B2 (en) | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US7139598B2 (en) | 2002-04-04 | 2006-11-21 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
US8046057B2 (en) | 2001-04-11 | 2011-10-25 | Clarke Dana S | Tissue structure identification in advance of instrument |
US20020158211A1 (en) | 2001-04-16 | 2002-10-31 | Dakota Technologies, Inc. | Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures |
DE10118760A1 (de) | 2001-04-17 | 2002-10-31 | Med Laserzentrum Luebeck Gmbh | Verfahren zur Ermittlung der Laufzeitverteilung und Anordnung |
EP2333523B1 (en) | 2001-04-30 | 2020-04-08 | The General Hospital Corporation | Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating |
US7616986B2 (en) | 2001-05-07 | 2009-11-10 | University Of Washington | Optical fiber scanner for performing multimodal optical imaging |
US6717680B1 (en) * | 2001-05-25 | 2004-04-06 | Zygo Corp | Apparatus and method for phase-shifting interferometry |
US6701181B2 (en) * | 2001-05-31 | 2004-03-02 | Infraredx, Inc. | Multi-path optical catheter |
US6615062B2 (en) | 2001-05-31 | 2003-09-02 | Infraredx, Inc. | Referencing optical catheters |
US20030103995A1 (en) | 2001-06-04 | 2003-06-05 | Hamblin Michael R. | Detection and therapy of vulnerable plaque with photodynamic compounds |
DE60100064T2 (de) | 2001-06-07 | 2003-04-17 | Agilent Technologies Inc | Bestimmung der Eigenschaften eines optischen Gerätes |
US6879851B2 (en) | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
DE10129651B4 (de) | 2001-06-15 | 2010-07-08 | Carl Zeiss Jena Gmbh | Verfahren zur Kompensation der Dispersion in Signalen von Kurzkohärenz- und/oder OCT-Interferometern |
US6702744B2 (en) | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
US6685885B2 (en) * | 2001-06-22 | 2004-02-03 | Purdue Research Foundation | Bio-optical compact dist system |
US20040166593A1 (en) | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
WO2003003903A2 (en) | 2001-07-02 | 2003-01-16 | Palomar Medical Technologies, Inc. | Laser device for medical/cosmetic procedures |
US6795199B2 (en) * | 2001-07-18 | 2004-09-21 | Avraham Suhami | Method and apparatus for dispersion compensated reflected time-of-flight tomography |
JP4751534B2 (ja) | 2001-07-24 | 2011-08-17 | 大日本印刷株式会社 | 光学系及びそれを用いた装置 |
DE10137530A1 (de) | 2001-08-01 | 2003-02-13 | Presens Prec Sensing Gmbh | Anordnung und Verfahren zur Mehrfach-Fluoreszenzmessung |
WO2003011764A2 (en) | 2001-08-03 | 2003-02-13 | Volker Westphal | Real-time imaging system and method |
WO2003012405A2 (en) | 2001-08-03 | 2003-02-13 | Rollins Andrew M | Aspects of basic oct engine technologies for high speed optical coherence tomography and light source and other improvements in oct |
US20030030816A1 (en) | 2001-08-11 | 2003-02-13 | Eom Tae Bong | Nonlinearity error correcting method and phase angle measuring method for displacement measurement in two-freqency laser interferometer and displacement measurement system using the same |
US6900899B2 (en) | 2001-08-20 | 2005-05-31 | Agilent Technologies, Inc. | Interferometers with coated polarizing beam splitters that are rotated to optimize extinction ratios |
US20030045798A1 (en) | 2001-09-04 | 2003-03-06 | Richard Hular | Multisensor probe for tissue identification |
EP1293925A1 (en) | 2001-09-18 | 2003-03-19 | Agfa-Gevaert | Radiographic scoring method |
US6961123B1 (en) | 2001-09-28 | 2005-11-01 | The Texas A&M University System | Method and apparatus for obtaining information from polarization-sensitive optical coherence tomography |
JP2003102672A (ja) | 2001-10-01 | 2003-04-08 | Japan Science & Technology Corp | 病変等の対象部位を自動的に検知かつ治療または採取する方法およびその装置 |
DE10150934A1 (de) | 2001-10-09 | 2003-04-10 | Zeiss Carl Jena Gmbh | Verfahren und Anordnung zur tiefenaufgelösten Erfassung von Proben |
US7822470B2 (en) | 2001-10-11 | 2010-10-26 | Osypka Medical Gmbh | Method for determining the left-ventricular ejection time TLVE of a heart of a subject |
US6980299B1 (en) | 2001-10-16 | 2005-12-27 | General Hospital Corporation | Systems and methods for imaging a sample |
US6658278B2 (en) | 2001-10-17 | 2003-12-02 | Terumo Cardiovascular Systems Corporation | Steerable infrared imaging catheter having steering fins |
US7006231B2 (en) * | 2001-10-18 | 2006-02-28 | Scimed Life Systems, Inc. | Diffraction grating based interferometric systems and methods |
US6749344B2 (en) | 2001-10-24 | 2004-06-15 | Scimed Life Systems, Inc. | Connection apparatus for optical coherence tomography catheters |
US6661513B1 (en) | 2001-11-21 | 2003-12-09 | Roygbiv, Llc | Refractive-diffractive spectrometer |
AU2002360198A1 (en) | 2001-12-11 | 2003-07-09 | C2Cure Inc. | Apparatus, method and system for intravascular photographic imaging |
US20030216719A1 (en) | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
WO2003052883A2 (en) | 2001-12-14 | 2003-06-26 | Agilent Technologies, Inc. | Retro-reflecting device in particular for tunable lasers |
US7736301B1 (en) | 2001-12-18 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Rotatable ferrules and interfaces for use with an optical guidewire |
US7365858B2 (en) | 2001-12-18 | 2008-04-29 | Massachusetts Institute Of Technology | Systems and methods for phase measurements |
US6975891B2 (en) | 2001-12-21 | 2005-12-13 | Nir Diagnostics Inc. | Raman spectroscopic system with integrating cavity |
US6947787B2 (en) | 2001-12-21 | 2005-09-20 | Advanced Cardiovascular Systems, Inc. | System and methods for imaging within a body lumen |
EP1324051A1 (en) | 2001-12-26 | 2003-07-02 | Kevin R. Forrester | Motion measuring device |
US20080154090A1 (en) | 2005-01-04 | 2008-06-26 | Dune Medical Devices Ltd. | Endoscopic System for In-Vivo Procedures |
ATE503982T1 (de) * | 2002-01-11 | 2011-04-15 | Gen Hospital Corp | Vorrichtung zur oct bildaufnahme mit axialem linienfokus für verbesserte auflösung und tiefenschärfe |
US7072045B2 (en) | 2002-01-16 | 2006-07-04 | The Regents Of The University Of California | High resolution optical coherence tomography with an improved depth range using an axicon lens |
JP2005516187A (ja) | 2002-01-24 | 2005-06-02 | ザ ジェネラル ホスピタル コーポレーション | スペクトル帯域の並列検出による測距並びに低コヒーレンス干渉法(lci)及び光学コヒーレンス断層撮影法(oct)信号の雑音低減のための装置及び方法 |
US7355716B2 (en) | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
WO2003069272A1 (fr) | 2002-02-14 | 2003-08-21 | Imalux Corporation | Procede d'examen d'objet et interferometre optique permettant la mise en oeuvre dudit procede |
US20030165263A1 (en) | 2002-02-19 | 2003-09-04 | Hamer Michael J. | Histological assessment |
US7116887B2 (en) | 2002-03-19 | 2006-10-03 | Nufern | Optical fiber |
US6704590B2 (en) | 2002-04-05 | 2004-03-09 | Cardiac Pacemakers, Inc. | Doppler guiding catheter using sensed blood turbulence levels |
US7006232B2 (en) | 2002-04-05 | 2006-02-28 | Case Western Reserve University | Phase-referenced doppler optical coherence tomography |
US7113818B2 (en) | 2002-04-08 | 2006-09-26 | Oti Ophthalmic Technologies Inc. | Apparatus for high resolution imaging of moving organs |
US7016048B2 (en) | 2002-04-09 | 2006-03-21 | The Regents Of The University Of California | Phase-resolved functional optical coherence tomography: simultaneous imaging of the stokes vectors, structure, blood flow velocity, standard deviation and birefringence in biological samples |
US20030236443A1 (en) | 2002-04-19 | 2003-12-25 | Cespedes Eduardo Ignacio | Methods and apparatus for the identification and stabilization of vulnerable plaque |
US7503904B2 (en) | 2002-04-25 | 2009-03-17 | Cardiac Pacemakers, Inc. | Dual balloon telescoping guiding catheter |
JP3834789B2 (ja) | 2002-05-17 | 2006-10-18 | 独立行政法人科学技術振興機構 | 自律型超短光パルス圧縮・位相補償・波形整形装置 |
US7364296B2 (en) | 2002-06-12 | 2008-04-29 | University Of Rochester | Method and apparatus for improving both lateral and axial resolution in ophthalmoscopy |
US7272252B2 (en) | 2002-06-12 | 2007-09-18 | Clarient, Inc. | Automated system for combining bright field and fluorescent microscopy |
RU2213421C1 (ru) | 2002-06-21 | 2003-09-27 | Южно-Российский государственный университет экономики и сервиса | Динамическое запоминающее устройство радиосигналов |
JP4045140B2 (ja) | 2002-06-21 | 2008-02-13 | 国立大学法人 筑波大学 | 偏光感受型光スペクトル干渉コヒーレンストモグラフィー装置及び該装置による試料内部の偏光情報の測定方法 |
US20040039252A1 (en) * | 2002-06-27 | 2004-02-26 | Koch Kenneth Elmon | Self-navigating endotracheal tube |
JP3621693B2 (ja) | 2002-07-01 | 2005-02-16 | フジノン株式会社 | 干渉計装置 |
US7072047B2 (en) | 2002-07-12 | 2006-07-04 | Case Western Reserve University | Method and system for quantitative image correction for optical coherence tomography |
JP3950378B2 (ja) | 2002-07-19 | 2007-08-01 | 新日本製鐵株式会社 | 同期機 |
JP4258015B2 (ja) | 2002-07-31 | 2009-04-30 | 毅 椎名 | 超音波診断システム、歪み分布表示方法及び弾性係数分布表示方法 |
US7283247B2 (en) | 2002-09-25 | 2007-10-16 | Olympus Corporation | Optical probe system |
WO2004029566A1 (en) | 2002-09-26 | 2004-04-08 | Bio Techplex Corporation | Method and apparatus for screening using a waveform modulated led |
US6842254B2 (en) | 2002-10-16 | 2005-01-11 | Fiso Technologies Inc. | System and method for measuring an optical path difference in a sensing interferometer |
WO2004034869A2 (en) | 2002-10-18 | 2004-04-29 | Arieh Sher | Atherectomy system with imaging guidewire |
US20040092829A1 (en) | 2002-11-07 | 2004-05-13 | Simon Furnish | Spectroscope with modified field-of-view |
JP4246986B2 (ja) | 2002-11-18 | 2009-04-02 | 株式会社町田製作所 | 振動物体観察システム及び声帯観察用処理装置 |
US6847449B2 (en) | 2002-11-27 | 2005-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for reducing speckle in optical coherence tomography images |
EP1426799A3 (en) | 2002-11-29 | 2005-05-18 | Matsushita Electric Industrial Co., Ltd. | Optical demultiplexer, optical multi-/demultiplexer, and optical device |
DE10260256B9 (de) | 2002-12-20 | 2007-03-01 | Carl Zeiss | Interferometersystem und Meß-/Bearbeitungswerkzeug |
GB0229734D0 (en) | 2002-12-23 | 2003-01-29 | Qinetiq Ltd | Grading oestrogen and progesterone receptors expression |
JP4148771B2 (ja) | 2002-12-27 | 2008-09-10 | 株式会社トプコン | 医療機械のレーザ装置 |
US7123363B2 (en) | 2003-01-03 | 2006-10-17 | Rose-Hulman Institute Of Technology | Speckle pattern analysis method and system |
US8054468B2 (en) | 2003-01-24 | 2011-11-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US7075658B2 (en) | 2003-01-24 | 2006-07-11 | Duke University | Method for optical coherence tomography imaging with molecular contrast |
US7567349B2 (en) | 2003-03-31 | 2009-07-28 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
JP2006516739A (ja) | 2003-01-24 | 2006-07-06 | ザ・ジェネラル・ホスピタル・コーポレイション | 低コヒーレンス干渉計を用いて組織を識別するためのシステムおよび方法 |
US6943892B2 (en) | 2003-01-29 | 2005-09-13 | Sarnoff Corporation | Instrument having a multi-mode optical element and method |
WO2004073501A2 (en) | 2003-02-20 | 2004-09-02 | Gutin Mikhail | Optical coherence tomography with 3d coherence scanning |
JP4338412B2 (ja) | 2003-02-24 | 2009-10-07 | Hoya株式会社 | 共焦点プローブおよび共焦点顕微鏡 |
US7271918B2 (en) | 2003-03-06 | 2007-09-18 | Zygo Corporation | Profiling complex surface structures using scanning interferometry |
JP2004317437A (ja) | 2003-04-18 | 2004-11-11 | Olympus Corp | 光イメージング装置 |
US7110109B2 (en) | 2003-04-18 | 2006-09-19 | Ahura Corporation | Raman spectroscopy system and method and specimen holder therefor |
US7347548B2 (en) | 2003-05-01 | 2008-03-25 | The Cleveland Clinic Foundation | Method and apparatus for measuring a retinal sublayer characteristic |
JP4571625B2 (ja) | 2003-05-05 | 2010-10-27 | ディーフォーディー テクノロジーズ エルエルシー | 光断層映像法による画像化 |
CN101785656B (zh) | 2003-05-12 | 2012-08-15 | 富士胶片株式会社 | 气囊式内窥镜的气囊控制装置 |
SE527164C2 (sv) | 2003-05-14 | 2006-01-10 | Spectracure Ab | Anordning och metod för terapi och diagnostik innefattande optiska komponenter för distribution av strålning |
US7376455B2 (en) | 2003-05-22 | 2008-05-20 | Scimed Life Systems, Inc. | Systems and methods for dynamic optical imaging |
WO2004111929A2 (en) | 2003-05-28 | 2004-12-23 | Duke University | Improved system for fourier domain optical coherence tomography |
EP1627248A4 (en) | 2003-05-29 | 2008-06-04 | Univ Michigan | ELECTRONIC SCANNING MICROSCOPE WITH DOUBLE SHEATH FIBERS |
EP1644697A4 (en) * | 2003-05-30 | 2006-11-29 | Univ Duke | SYSTEM AND METHOD FOR BROADBAND QUADRATURE INTERFEROMETRY WITH LOW COHERENCE |
US7263394B2 (en) | 2003-06-04 | 2007-08-28 | Tomophase Corporation | Coherence-gated optical glucose monitor |
US6943881B2 (en) | 2003-06-04 | 2005-09-13 | Tomophase Corporation | Measurements of optical inhomogeneity and other properties in substances using propagation modes of light |
KR101546024B1 (ko) | 2003-06-06 | 2015-08-20 | 더 제너럴 하스피탈 코포레이션 | 파장 동조 소스용 방법 및 장치 |
US7458683B2 (en) | 2003-06-16 | 2008-12-02 | Amo Manufacturing Usa, Llc | Methods and devices for registering optical measurement datasets of an optical system |
US7170913B2 (en) | 2003-06-19 | 2007-01-30 | Multiwave Photonics, Sa | Laser source with configurable output beam characteristics |
US20040260182A1 (en) | 2003-06-23 | 2004-12-23 | Zuluaga Andres F. | Intraluminal spectroscope with wall contacting probe |
JP4677208B2 (ja) | 2003-07-29 | 2011-04-27 | オリンパス株式会社 | 共焦点顕微鏡 |
US6992778B2 (en) * | 2003-08-08 | 2006-01-31 | Mitutoyo Corporation | Method and apparatus for self-calibration of a tunable-source phase shifting interferometer |
US20050038322A1 (en) | 2003-08-11 | 2005-02-17 | Scimed Life Systems | Imaging endoscope |
WO2005017495A2 (en) | 2003-08-14 | 2005-02-24 | University Of Central Florida | Interferometric sensor for characterizing materials |
US7539530B2 (en) | 2003-08-22 | 2009-05-26 | Infraredx, Inc. | Method and system for spectral examination of vascular walls through blood during cardiac motion |
US20050083534A1 (en) | 2003-08-28 | 2005-04-21 | Riza Nabeel A. | Agile high sensitivity optical sensor |
JP4590171B2 (ja) | 2003-08-29 | 2010-12-01 | オリンパス株式会社 | カプセル型医療装置および当該カプセル型医療装置備えた医療装置 |
JP2005077964A (ja) * | 2003-09-03 | 2005-03-24 | Fujitsu Ltd | 分光装置 |
US20050057680A1 (en) * | 2003-09-16 | 2005-03-17 | Agan Martin J. | Method and apparatus for controlling integration time in imagers |
US20050059894A1 (en) | 2003-09-16 | 2005-03-17 | Haishan Zeng | Automated endoscopy device, diagnostic method, and uses |
US7935055B2 (en) | 2003-09-19 | 2011-05-03 | Siemens Medical Solutions Usa, Inc. | System and method of measuring disease severity of a patient before, during and after treatment |
US6949072B2 (en) | 2003-09-22 | 2005-09-27 | Infraredx, Inc. | Devices for vulnerable plaque detection |
US8172747B2 (en) | 2003-09-25 | 2012-05-08 | Hansen Medical, Inc. | Balloon visualization for traversing a tissue wall |
JP3796550B2 (ja) | 2003-09-26 | 2006-07-12 | 日本電信電話株式会社 | 光干渉トモグラフィ装置 |
EP1677095A1 (en) | 2003-09-26 | 2006-07-05 | The Kitasato Gakuen Foundation | Variable-wavelength light generator and light interference tomograph |
US7142835B2 (en) | 2003-09-29 | 2006-11-28 | Silicon Laboratories, Inc. | Apparatus and method for digital image correction in a receiver |
US7292792B2 (en) | 2003-09-30 | 2007-11-06 | Lucent Technologies Inc. | High speed modulation of optical subcarriers |
DE10349230A1 (de) | 2003-10-23 | 2005-07-07 | Carl Zeiss Meditec Ag | Gerät zur interferometrischen Augenlängenmessung mit erhöhter Empfindlichkeit |
KR101384553B1 (ko) * | 2003-10-27 | 2014-04-11 | 더 제너럴 하스피탈 코포레이션 | 주파수 영역 간섭법을 이용하여 광 영상화를 수행하는 방법 및 장치 |
DE10351319B4 (de) | 2003-10-31 | 2005-10-20 | Med Laserzentrum Luebeck Gmbh | Interferometer für die optische Kohärenztomographie |
US7130320B2 (en) | 2003-11-13 | 2006-10-31 | Mitutoyo Corporation | External cavity laser with rotary tuning element |
WO2005054780A1 (en) | 2003-11-28 | 2005-06-16 | The General Hospital Corporation | Method and apparatus for three-dimensional spectrally encoded imaging |
US7359062B2 (en) | 2003-12-09 | 2008-04-15 | The Regents Of The University Of California | High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure |
DE10358735B4 (de) | 2003-12-15 | 2011-04-21 | Siemens Ag | Kathetereinrichtung umfassend einen Katheter, insbesondere einen intravaskulären Katheter |
JP4414771B2 (ja) | 2004-01-08 | 2010-02-10 | オリンパス株式会社 | 共焦点顕微分光装置 |
RU2255426C1 (ru) | 2004-02-19 | 2005-06-27 | Южно-Российский государственный университет экономики и сервиса | Динамическое запоминающее устройство радиосигналов с последовательной бинарной волоконно-оптической структурой |
JP4462959B2 (ja) | 2004-02-25 | 2010-05-12 | 富士通株式会社 | 顕微鏡画像撮影システム及び方法 |
US20110178409A1 (en) | 2004-02-27 | 2011-07-21 | Optiscan Pty Ltd | Optical Element |
US7242480B2 (en) | 2004-05-14 | 2007-07-10 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
US20050254059A1 (en) | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometric system for optical metrology |
US7190464B2 (en) * | 2004-05-14 | 2007-03-13 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
EP1754016B1 (en) | 2004-05-29 | 2016-05-18 | The General Hospital Corporation | Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging |
US7447408B2 (en) | 2004-07-02 | 2008-11-04 | The General Hospital Corproation | Imaging system and related techniques |
DE102004035269A1 (de) * | 2004-07-21 | 2006-02-16 | Rowiak Gmbh | Laryngoskop mit OCT |
KR101332222B1 (ko) * | 2004-08-06 | 2013-11-22 | 더 제너럴 하스피탈 코포레이션 | 광간섭 단층촬영법을 이용해서 샘플 내에서 적어도 하나의 위치를 결정하는 방법, 시스템 및 그 방법을 구현하기 위한 소프트웨어가 저장되어 컴퓨터로 판독 가능한 매체 |
WO2006020605A2 (en) | 2004-08-10 | 2006-02-23 | The Regents Of The University Of California | Device and method for the delivery and/or elimination of compounds in tissue |
US7365859B2 (en) | 2004-09-10 | 2008-04-29 | The General Hospital Corporation | System and method for optical coherence imaging |
US7366376B2 (en) | 2004-09-29 | 2008-04-29 | The General Hospital Corporation | System and method for optical coherence imaging |
US7113625B2 (en) | 2004-10-01 | 2006-09-26 | U.S. Pathology Labs, Inc. | System and method for image analysis of slides |
SE0402435L (sv) | 2004-10-08 | 2006-04-09 | Trajan Badju | Förfarande och system för alstring av tredimensionella bilder |
JP2008517281A (ja) | 2004-10-22 | 2008-05-22 | ファーミスカン・オーストラリア・ピーティーワイ・リミテッド | 分析の方法および装置 |
JP5175101B2 (ja) | 2004-10-29 | 2013-04-03 | ザ ジェネラル ホスピタル コーポレイション | 偏光感応性光コヒーレンストモグラフィを用いて偏光非解消の偏光パラメータを測定するジョーンズ行列に基づく解析を行うシステム及び方法 |
EP1807722B1 (en) | 2004-11-02 | 2022-08-10 | The General Hospital Corporation | Fiber-optic rotational device, optical system for imaging a sample |
US7417740B2 (en) | 2004-11-12 | 2008-08-26 | Medeikon Corporation | Single trace multi-channel low coherence interferometric sensor |
US8617152B2 (en) | 2004-11-15 | 2013-12-31 | Medtronic Ablation Frontiers Llc | Ablation system with feedback |
GB0425419D0 (en) | 2004-11-18 | 2004-12-22 | Sira Ltd | Interference apparatus and method and probe |
WO2006058187A2 (en) | 2004-11-23 | 2006-06-01 | Robert Eric Betzig | Optical lattice microscopy |
GB0426609D0 (en) | 2004-12-03 | 2005-01-05 | Ic Innovations Ltd | Analysis |
JP2006162366A (ja) | 2004-12-06 | 2006-06-22 | Fujinon Corp | 光断層映像装置 |
US7450242B2 (en) * | 2004-12-10 | 2008-11-11 | Fujifilm Corporation | Optical tomography apparatus |
US8004686B2 (en) * | 2004-12-14 | 2011-08-23 | Luna Innovations Inc. | Compensating for time varying phase changes in interferometric measurements |
US7336366B2 (en) * | 2005-01-20 | 2008-02-26 | Duke University | Methods and systems for reducing complex conjugate ambiguity in interferometric data |
US8315282B2 (en) | 2005-01-20 | 2012-11-20 | Massachusetts Institute Of Technology | Fourier domain mode locking: method and apparatus for control and improved performance |
US7342659B2 (en) | 2005-01-21 | 2008-03-11 | Carl Zeiss Meditec, Inc. | Cross-dispersed spectrometer in a spectral domain optical coherence tomography system |
US7330270B2 (en) | 2005-01-21 | 2008-02-12 | Carl Zeiss Meditec, Inc. | Method to suppress artifacts in frequency-domain optical coherence tomography |
HU227859B1 (en) | 2005-01-27 | 2012-05-02 | E Szilveszter Vizi | Real-time 3d nonlinear microscope measuring system and its application |
US7267494B2 (en) | 2005-02-01 | 2007-09-11 | Finisar Corporation | Fiber stub for cladding mode coupling reduction |
US7860555B2 (en) | 2005-02-02 | 2010-12-28 | Voyage Medical, Inc. | Tissue visualization and manipulation system |
US7664300B2 (en) | 2005-02-03 | 2010-02-16 | Sti Medical Systems, Llc | Uterine cervical cancer computer-aided-diagnosis (CAD) |
DE102005007574B3 (de) | 2005-02-18 | 2006-08-31 | Siemens Ag | Kathetereinrichtung |
EP1910996A1 (en) | 2005-02-23 | 2008-04-16 | Lyncee Tec S.A. | Wave front sensing method and apparatus |
JP4628820B2 (ja) | 2005-02-25 | 2011-02-09 | サンテック株式会社 | 波長走査型ファイバレーザ光源 |
US7530948B2 (en) | 2005-02-28 | 2009-05-12 | University Of Washington | Tethered capsule endoscope for Barrett's Esophagus screening |
DE102005010790A1 (de) | 2005-03-09 | 2006-09-14 | Basf Ag | Photovoltaische Zelle mit einem darin enthaltenen photovoltaisch aktiven Halbleitermaterial |
US20060224053A1 (en) | 2005-03-30 | 2006-10-05 | Skyline Biomedical, Inc. | Apparatus and method for non-invasive and minimally-invasive sensing of venous oxygen saturation and pH levels |
JP2008538612A (ja) | 2005-04-22 | 2008-10-30 | ザ ジェネラル ホスピタル コーポレイション | スペクトルドメイン偏光感受型光コヒーレンストモグラフィを提供することの可能な構成、システム、及び方法 |
WO2006116362A2 (en) | 2005-04-25 | 2006-11-02 | The Trustees Of Boston University | Structured substrates for optical surface profiling |
US20070009935A1 (en) | 2005-05-13 | 2007-01-11 | The General Hospital Corporation | Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample |
WO2006127692A2 (en) * | 2005-05-23 | 2006-11-30 | Hess Harald F | Optical microscopy with phototransformable optical labels |
JP2008542758A (ja) | 2005-05-31 | 2008-11-27 | ザ ジェネラル ホスピタル コーポレイション | スペクトルコード化ヘテロダイン干渉法を画像化に使用可能なシステム、方法、及び装置 |
EP1889037A2 (en) | 2005-06-01 | 2008-02-20 | The General Hospital Corporation | Apparatus, method and system for performing phase-resolved optical frequency domain imaging |
JP2008545500A (ja) | 2005-06-07 | 2008-12-18 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | レーザ光学フィードバック断層撮影センサ及び方法 |
US7391520B2 (en) | 2005-07-01 | 2008-06-24 | Carl Zeiss Meditec, Inc. | Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver |
WO2007005913A2 (en) | 2005-07-01 | 2007-01-11 | Infotonics Technology Center, Inc. | Non-invasive monitoring system |
DE102005034443A1 (de) | 2005-07-22 | 2007-02-22 | Carl Zeiss Jena Gmbh | Auflösungsgesteigerte Lumineszenz-Mikroskopie |
US7292347B2 (en) * | 2005-08-01 | 2007-11-06 | Mitutoyo Corporation | Dual laser high precision interferometer |
US7173401B1 (en) * | 2005-08-01 | 2007-02-06 | Integrated System Solution Corp. | Differential amplifier and low drop-out regulator with thereof |
JP4376837B2 (ja) | 2005-08-05 | 2009-12-02 | サンテック株式会社 | 波長走査型レーザ光源 |
DE602006017558D1 (de) | 2005-08-09 | 2010-11-25 | Gen Hospital Corp | Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie |
US7668342B2 (en) | 2005-09-09 | 2010-02-23 | Carl Zeiss Meditec, Inc. | Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues |
US8357917B2 (en) | 2005-09-10 | 2013-01-22 | Baer Stephen C | High resolution microscopy using an optically switchable fluorophore |
US8114581B2 (en) | 2005-09-15 | 2012-02-14 | The Regents Of The University Of California | Methods and compositions for detecting neoplastic cells |
KR100743591B1 (ko) | 2005-09-23 | 2007-07-27 | 한국과학기술원 | 사이드 로브가 제거된 공초점 자가 간섭 현미경 |
EP1937137B1 (en) | 2005-09-29 | 2022-06-15 | General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US7450241B2 (en) * | 2005-09-30 | 2008-11-11 | Infraredx, Inc. | Detecting vulnerable plaque |
US7400410B2 (en) | 2005-10-05 | 2008-07-15 | Carl Zeiss Meditec, Inc. | Optical coherence tomography for eye-length measurement |
WO2007044612A2 (en) | 2005-10-07 | 2007-04-19 | Bioptigen, Inc. | Imaging systems using unpolarized light and related methods and controllers |
WO2007044786A2 (en) | 2005-10-11 | 2007-04-19 | Zygo Corporation | Interferometry method and system including spectral decomposition |
CA2626116C (en) | 2005-10-11 | 2012-08-21 | Duke University | Systems and method for endoscopic angle-resolved low coherence interferometry |
US7408649B2 (en) | 2005-10-26 | 2008-08-05 | Kla-Tencor Technologies Corporation | Method and apparatus for optically analyzing a surface |
US9087368B2 (en) * | 2006-01-19 | 2015-07-21 | The General Hospital Corporation | Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof |
US20070223006A1 (en) | 2006-01-19 | 2007-09-27 | The General Hospital Corporation | Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements |
US8145018B2 (en) | 2006-01-19 | 2012-03-27 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements |
GB0601183D0 (en) | 2006-01-20 | 2006-03-01 | Perkinelmer Ltd | Improvements in and relating to imaging |
WO2007090147A2 (en) | 2006-01-31 | 2007-08-09 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
WO2007092911A2 (en) | 2006-02-08 | 2007-08-16 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy |
US8184367B2 (en) | 2006-02-15 | 2012-05-22 | University Of Central Florida Research Foundation | Dynamically focused optical instrument |
DE102006008990B4 (de) | 2006-02-23 | 2008-05-21 | Atmos Medizintechnik Gmbh & Co. Kg | Verfahren und Anordnung zur Erzeugung eines dem Öffnungszustand der Stimmlippen des Kehlkopfes entsprechenden Signals |
TWI414543B (zh) | 2006-02-24 | 2013-11-11 | Toray Industries | 纖維強化熱可塑性樹脂成形體、成形材料及其製法 |
JP2007271761A (ja) | 2006-03-30 | 2007-10-18 | Fujitsu Ltd | 分光装置および波長分散制御装置 |
US7742173B2 (en) | 2006-04-05 | 2010-06-22 | The General Hospital Corporation | Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample |
US20070253901A1 (en) | 2006-04-27 | 2007-11-01 | David Deng | Atherosclerosis genes and related reagents and methods of use thereof |
WO2007127395A2 (en) | 2006-04-28 | 2007-11-08 | Bioptigen, Inc. | Methods, systems and computer program products for optical coherence tomography (oct) using automatic dispersion compensation |
WO2007133964A2 (en) | 2006-05-12 | 2007-11-22 | The General Hospital Corporation | Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images |
US7460248B2 (en) | 2006-05-15 | 2008-12-02 | Carestream Health, Inc. | Tissue imaging system |
EP1859727A1 (en) | 2006-05-26 | 2007-11-28 | Stichting voor de Technische Wetenschappen | optical triggering system for stroboscopy and a stroboscopic system |
US7599074B2 (en) | 2006-06-19 | 2009-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Grating angle magnification enhanced angular sensor and scanner |
US20070291277A1 (en) | 2006-06-20 | 2007-12-20 | Everett Matthew J | Spectral domain optical coherence tomography system |
JP5507247B2 (ja) | 2006-08-28 | 2014-05-28 | サーモ エレクトロン サイエンティフィック インストルメンツ リミテッド ライアビリティ カンパニー | 画像駆動分析による分光器顕微鏡法 |
WO2008049118A2 (en) | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s) |
WO2008052155A2 (en) | 2006-10-26 | 2008-05-02 | Cornell Research Foundation, Inc. | System for producing optical pulses of a desired wavelength using cherenkov radiation |
JP2010508056A (ja) | 2006-10-30 | 2010-03-18 | エルフィ−テック リミテッド | 生物学的パラメータの体内での測定のためのシステム及び方法 |
DE102006054556A1 (de) | 2006-11-20 | 2008-05-21 | Zimmer Medizinsysteme Gmbh | Vorrichtung und Verfahren zum nicht-invasiven, optischen Erfassen von chemischen und physikalischen Blutwerten und Körperinhaltsstoffen |
US20080204762A1 (en) | 2007-01-17 | 2008-08-28 | Duke University | Methods, systems, and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (FDOCT) systems using integrating buckets |
EP2102583A2 (en) * | 2007-01-19 | 2009-09-23 | The General Hospital Corporation | Apparatus and method for controlling ranging depth in optical frequency domain imaging |
US20080226029A1 (en) | 2007-03-12 | 2008-09-18 | Weir Michael P | Medical device including scanned beam unit for imaging and therapy |
JP5227525B2 (ja) | 2007-03-23 | 2013-07-03 | 株式会社日立製作所 | 生体光計測装置 |
US8222385B2 (en) | 2007-03-26 | 2012-07-17 | National University Corporation Tokyo University of Marine Science Technology | Germ cell marker using fish vasa gene |
WO2008124845A2 (en) | 2007-04-10 | 2008-10-16 | University Of Southern California | Methods and systems for blood flow measurement using doppler optical coherence tomography |
US8115919B2 (en) | 2007-05-04 | 2012-02-14 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy |
US7799558B1 (en) | 2007-05-22 | 2010-09-21 | Dultz Shane C | Ligand binding assays on microarrays in closed multiwell plates |
US8166967B2 (en) * | 2007-08-15 | 2012-05-01 | Chunyuan Qiu | Systems and methods for intubation |
WO2009033064A2 (en) | 2007-09-05 | 2009-03-12 | The General Hospital Corporation | Systems, methods and computer-accessible medium for providing spectral-domain optical coherence phase microscopy for cell and deep tissue imaging |
WO2009049296A2 (en) | 2007-10-12 | 2009-04-16 | The General Hospital Corporation | Systems and processes for optical imaging of luminal anatomic structures |
US9332942B2 (en) | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
JP5192247B2 (ja) | 2008-01-29 | 2013-05-08 | 並木精密宝石株式会社 | Octプローブ |
US7898656B2 (en) | 2008-04-30 | 2011-03-01 | The General Hospital Corporation | Apparatus and method for cross axis parallel spectroscopy |
US8184298B2 (en) | 2008-05-21 | 2012-05-22 | The Board Of Trustees Of The University Of Illinois | Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization |
CN102046071B (zh) | 2008-06-02 | 2013-11-06 | 光学实验室成像公司 | 用于从光学相干断层扫描图像获得组织特性的定量方法 |
JP5324839B2 (ja) | 2008-06-19 | 2013-10-23 | 株式会社トプコン | 光画像計測装置 |
JP5546112B2 (ja) * | 2008-07-07 | 2014-07-09 | キヤノン株式会社 | 眼科撮像装置および眼科撮像方法 |
US8133127B1 (en) | 2008-07-21 | 2012-03-13 | Synder Terrance W | Sports training device and methods of use |
US20110160681A1 (en) | 2008-12-04 | 2011-06-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters having light removable coatings based on a sensed condition |
CN101744601B (zh) | 2008-12-05 | 2013-04-24 | 德昌电机(深圳)有限公司 | 胶囊式成像装置和体内图像获取系统 |
US8457715B2 (en) | 2009-04-08 | 2013-06-04 | Covidien Lp | System and method for determining placement of a tracheal tube |
US9089331B2 (en) * | 2009-07-31 | 2015-07-28 | Case Western Reserve University | Characterizing ablation lesions using optical coherence tomography (OCT) |
WO2011055376A1 (en) | 2009-11-09 | 2011-05-12 | Tata Institute Of Fundamental Research | Biological laser plasma x-ray point source |
EP2542145B1 (en) | 2010-03-05 | 2020-08-12 | The General Hospital Corporation | Systems which provide microscopic images of at least one anatomical structure at a particular resolution |
-
2006
- 2006-08-09 DE DE602006017558T patent/DE602006017558D1/de active Active
- 2006-08-09 ES ES06813365T patent/ES2354287T3/es active Active
- 2006-08-09 WO PCT/US2006/031275 patent/WO2007019574A2/en active Application Filing
- 2006-08-09 AT AT06813365T patent/ATE484727T1/de not_active IP Right Cessation
- 2006-08-09 EP EP10154589A patent/EP2207008A1/en not_active Withdrawn
- 2006-08-09 US US11/502,330 patent/US9441948B2/en active Active
- 2006-08-09 JP JP2008526211A patent/JP5547402B2/ja active Active
- 2006-08-09 KR KR1020087005720A patent/KR101387454B1/ko active IP Right Grant
- 2006-08-09 EP EP06813365A patent/EP1913332B1/en active Active
- 2006-08-09 EP EP10182743.4A patent/EP2267404B1/en active Active
- 2006-08-09 CN CN2006800286977A patent/CN101238347B/zh not_active Expired - Fee Related
-
2013
- 2013-07-26 JP JP2013155580A patent/JP5718988B2/ja active Active
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102273105A (zh) * | 2009-01-12 | 2011-12-07 | 阿卡特朗讯美国公司 | 具有共享的光学混合器及多波长本机振荡器的多波长相干接收器 |
CN102188237A (zh) * | 2011-05-26 | 2011-09-21 | 浙江大学 | 基于位相复用的全量程扫频oct成像方法及系统 |
CN102188237B (zh) * | 2011-05-26 | 2012-11-14 | 浙江大学 | 基于位相复用的全量程扫频oct成像方法及系统 |
CN104205678A (zh) * | 2012-04-13 | 2014-12-10 | 阿尔卡特朗讯 | 非线性交叉偏振减轻算法 |
CN104205678B (zh) * | 2012-04-13 | 2016-11-30 | 阿尔卡特朗讯 | 非线性交叉偏振减轻算法 |
CN104641580A (zh) * | 2012-09-14 | 2015-05-20 | 阿尔卡特朗讯 | 通过线性光学采样的光学信号可视化 |
CN103829924A (zh) * | 2012-11-26 | 2014-06-04 | 三星电子株式会社 | 用于产生断层图像的设备和方法 |
US9618324B2 (en) | 2012-11-26 | 2017-04-11 | Samsung Electronics Co., Ltd. | Apparatus and method for generating tomography images |
CN103829924B (zh) * | 2012-11-26 | 2017-05-03 | 三星电子株式会社 | 用于产生断层图像的设备和方法 |
CN110960186A (zh) * | 2018-09-28 | 2020-04-07 | 株式会社多美 | 眼科装置 |
CN110456468A (zh) * | 2019-09-17 | 2019-11-15 | 安徽光纤光缆传输技术研究所(中国电子科技集团公司第八研究所) | 一种量子光器件空间混合集成组件 |
CN110456468B (zh) * | 2019-09-17 | 2024-04-05 | 安徽光纤光缆传输技术研究所(中国电子科技集团公司第八研究所) | 一种量子光器件空间混合集成组件 |
Also Published As
Publication number | Publication date |
---|---|
KR20080042883A (ko) | 2008-05-15 |
EP2267404A1 (en) | 2010-12-29 |
DE602006017558D1 (de) | 2010-11-25 |
EP2267404B1 (en) | 2016-10-05 |
JP2013253986A (ja) | 2013-12-19 |
WO2007019574A3 (en) | 2007-05-10 |
US9441948B2 (en) | 2016-09-13 |
JP5718988B2 (ja) | 2015-05-13 |
WO2007019574A2 (en) | 2007-02-15 |
EP2207008A1 (en) | 2010-07-14 |
EP1913332A2 (en) | 2008-04-23 |
ES2354287T3 (es) | 2011-03-11 |
EP1913332B1 (en) | 2010-10-13 |
JP5547402B2 (ja) | 2014-07-16 |
US20070035743A1 (en) | 2007-02-15 |
JP2009505073A (ja) | 2009-02-05 |
ATE484727T1 (de) | 2010-10-15 |
KR101387454B1 (ko) | 2014-04-22 |
CN101238347B (zh) | 2011-05-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101238347B (zh) | 执行光学相干层析术中的基于偏振的正交解调的设备、方法和存储介质 | |
US7929148B2 (en) | Optical coherence tomography implementation apparatus and method of use | |
US6633386B2 (en) | Optical pulse measurement using shearing interferometry, especially suitable for characterizing ultrashort pulses | |
US7903256B2 (en) | Methods, systems, and computer program products for performing real-time quadrature projection based Fourier domain optical coherence tomography | |
US7009691B2 (en) | System and method for removing the relative phase uncertainty in device characterizations performed with a polarimeter | |
US8854629B2 (en) | Optical coherence tomography system and method | |
CN103284691A (zh) | 用于使用频域干涉测量法进行光学成像的方法和设备 | |
CN108827601A (zh) | 一种光纤干涉仪臂长差的测量装置 | |
US20180372517A1 (en) | Sine-cosine optical frequency encoder devices based on optical polarization properties | |
EP2004041A1 (en) | Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample | |
CN109188454A (zh) | 基于数字锁相非线性校正的动态扫频干涉测距系统及方法 | |
WO2009017291A1 (en) | Scanning micrometer using heterodyne interferometer | |
CN101949685A (zh) | 光纤型激光自混合干涉仪及其测量方法 | |
CN108931478A (zh) | 单次采集无色散移相全场光学相干层析成像装置及方法 | |
US5200796A (en) | Method and apparatus for detecting and measuring a physical magnitude | |
CN215339483U (zh) | 气体分子吸收信号增强系统 | |
JP4583986B2 (ja) | 波長分散測定装置 | |
US5477382A (en) | Optical correlator system | |
KR20080067100A (ko) | 편광민감 광결맞음 생체영상기기용 간섭 시스템 | |
Meggitt | Fiber optic white-light interferometric sensors | |
KR101685375B1 (ko) | 편광 다중 방식의 파장 가변 광원 장치 및 이를 이용한 편광민감 광간섭단층촬영 이미징 시스템 | |
Santos et al. | A new electro-optical method for recovering white light interferometric signals | |
De Vine et al. | Signal response measurement of advanced interferometer configurations | |
JPH0331730A (ja) | 光周波数変化量測定装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110525 Termination date: 20200809 |
|
CF01 | Termination of patent right due to non-payment of annual fee |