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Publication numberCN101163514 A
Publication typeApplication
Application numberCN 200680013818
PCT numberPCT/EP2006/061748
Publication date16 Apr 2008
Filing date21 Apr 2006
Priority date24 Apr 2005
Also published asCN101163514B, EP1877121A1, EP1877121B1, US8197450, US8641683, US20090043264, US20100016806, US20120157932, WO2006114396A1
Publication number200680013818.0, CN 101163514 A, CN 101163514A, CN 200680013818, CN-A-101163514, CN101163514 A, CN101163514A, CN200680013818, CN200680013818.0, PCT/2006/61748, PCT/EP/2006/061748, PCT/EP/2006/61748, PCT/EP/6/061748, PCT/EP/6/61748, PCT/EP2006/061748, PCT/EP2006/61748, PCT/EP2006061748, PCT/EP200661748, PCT/EP6/061748, PCT/EP6/61748, PCT/EP6061748, PCT/EP661748
InventorsCS默勒, K格莱耶伯尔, ME汉森, S林内耶博格
Applicant诺和诺德公司
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
Injection device
CN 101163514 A
Abstract  translated from Chinese
一种用于从药瓶中注射设定剂量药物的注射装置具有螺母(13),该螺母在剂量设定操作期间被沿着带螺纹的活塞杆(4)向上旋拧。 A piston rod from the set injection dose vial injection means for having a nut (13), the nut during dose setting operation is threaded along (4) screwing up. 该螺母是通过旋转一剂量设定部件(17)而得以沿着活塞杆旋拧的。 The nut is by rotating a dose setting means (17) and can be screwed along the rod. 旋转联接机构包括能够沿轴向位移的联接部件(25),该联接部件依照轴向位移的函数而发生旋转。 Rotating the coupling means includes a coupling member along the axial displacement (25), axial displacement of the coupling member in accordance with a function of the rotation occurs. 在剂量设定期间,允许螺母相对于联接部件旋转。 During dose setting, allowing rotation of the nut relative to the coupling member. 在注射期间,联接部件可旋转地锁定在该螺母上。 During injection, the coupling member is rotatably locked in the nut. 这提供了一种螺母在剂量设定期间和在注射期间都旋转的剂量设定和注射机构。 This provides a nut during dose setting and dose setting and injection mechanism are rotated during the injection.
Claims(10)  translated from Chinese
1.一种注射装置包括: a.用于剂量设定和注射机构的壳体(1,101),该壳体具有近端末端和远端末端, b.可旋转的剂量设定部件(17,117), c.可轴向位移的活塞杆(4,104),该活塞杆具有第一螺纹(4a,104a)和附加的纵向延伸轨道(4b,104b), d.壳体上的中心开口(2b,102b),该中心开口用于接合活塞杆(4,104)的附加的纵向延伸轨道(4b,104b),这样在活塞杆(4,104)的轴向平移期间引导活塞杆(4,104)的角运动, e.螺纹螺母(13,113),该螺纹螺母接合活塞杆(4,104)的第一螺纹(4a,104a),该螺母在剂量设定期间可旋转地锁定在剂量设定部件(17,117)上, f.旋转联接机构(24,124,25,125,26,126,27,127),该旋转联接机构具有联接部件(25,125),该联接部件(25,125)能够沿轴向从第一位置位移到第二位置,该旋转联接机构在剂量设定期间允许螺母(13,113)相对于联接部件(25)进行角运动,同时在注射期间防止螺母(13,113)和联接部件(25,125)之间发生角运动, 其特征在于: 联接部件(25,125)与壳体(1,101)成角度地联接,从而迫使该联接部件在从所述第一到所述第二位置的轴向位移的至少一部分期间,依照联接部件(25,125)相对于壳体(1,101)的轴向位移的函数而成角度地移动。 1. An injection device comprising:. A dose setting and injection mechanism for a housing (1, 101), the housing having a proximal end and a distal end, b rotatable dose setting member (17. , 117), c. axially displaceable piston rod (4, 104), the piston rod having a first thread (4a, 104a) and the additional longitudinally extending track (4b, 104b), d. the center of the housing an opening (2b, 102b), the central opening for engaging the piston rod (4, 104) of the additional longitudinally extending track (4b, 104b), so that during the piston rod (4, 104) of the axial translation of the piston rod guide ( 4,104) of angular motion, e. threaded nut (13, 113), the threaded nut engaging rod (4,104) of the first thread (4a, 104a), the locking nut is rotatably during dose setting the dose setting member (17,117), f. rotary coupling mechanism (24,124,25,125,26,126,27,127), the spin coupling mechanism has a coupling member (25, 125), the coupling means (25, 125) can be displaced in the axial direction from the first position to the second position, the rotational coupling mechanism during dose setting allows the nut (13, 113) with respect to the coupling member (25) of angular movement, while injection During prevent angular movement between the nut (13, 113) and the coupling member (25, 125), characterized in that: the coupling member (25, 125) with the housing (1, 101) angularly coupled, thereby forcing the coupling member during at least a portion of the axial displacement from said first to said second position, in accordance with the coupling member (25, 125) to move from the perspective of the function of the axial displacement of the housing (1, 101) with respect to .
2. 按照权利要求1所述的注射装置,其特征在于,剂量设定部件(17, 117)能够由于该剂量设定部件相对于壳体(1, 101)的旋转而沿轴向位移,并且联接部件(25, 125)与剂量设定部件(17,117)联接成使剂量设定部件(17, 117)的轴向位移基本上对应于联接部件(25, 125)的轴向位移。 2. An injection device according to claim 1, characterized in that the dose setting member (17, 117) can be due to the rotation of the housing the dose setting member (1, 101) with respect to the axial direction displacement, and the coupling member (25, 125) and the dose setting member (17, 117) is coupled so that the dose setting member (17, 117) substantially corresponds to the axial displacement of the axial displacement to the coupling member (25, 125).
3. 按照权利要求1或2所述的注射装置,其特征在于,联接部件(25, 125)具有螺紋(28, 128 )并且以螺紋连接方式与设置在壳体(l, 101)上的螺旋状螺紋(37, 137)接合,壳体的所述螺紋(37, 137)具有恒定的螺距。 3. An injection device according to claim 1 or claim 2, characterized in that the coupling member (25, 125) having a thread (28, 128) and is disposed in a threaded connection with the housing (l, 101) on the spiral shaped thread (37, 137) engaging said threaded housing (37, 137) has a constant pitch.
4. 按照权利要求1或2所述的注射装置,其特征在于,联接部件(25, 125)具有凸起(28, 128),该凸起与设置在壳体(1, 101) 上的纵向延伸的轨道(37, 137)配套并接合,该纵向延伸的轨道(37, 137)沿着轨道(37, 137)的延伸方向具有可变的螺距。 An injection device according to claim 1 or claim 2, characterized in that the coupling member (25, 125) having a projection (28, 128), with the projection provided on the housing (1, 101) on the longitudinal extending rails (37, 137) and supporting engagement, the longitudinally extending track (37, 137) having a variable pitch along the track (37, 137) extending direction.
5. 按照前述权利要求中任何一项所述的注射装置,其特征在于, 旋转联接机构(24, 25, 26, 27, 28)包括在剂量设定期间提供与剂量体积相应的增量啼哒声的增量反馈机构。 5. claimed in any of the preceding injection device according to, characterized in that the rotational coupling means (24, 25, 26, 27, 28) comprising providing during dose setting and dose volume increment corresponding to cry pyridazin Incremental sound feedback mechanism.
6. 按照前述权利要求中任何一项所述的注射装置,其特征在于, 注射装置此外还包括注射按钮(19, 119)和将该注射按钮(19, 119) 的轴向运动与螺母(13, 113)的轴向运动联接起来的传动箱组件(9, 109)。 6. claimed in any of the preceding injection device according to, characterized in that the injection device also includes an injection button (19, 119) and the injection button (19, 119) of the axial movement of the nut (13 113) axial movement to link up the gearbox module (9, 109).
7. 按照权利要求6所述的注射装置,其特征在于,传动箱组件(9, 109)提供造成螺母(13, 113)在注射期间沿着远端方向移动一段距离的传动,该段距离小于注射按钮(19, 119)移动的距离。 7. An injection device according to claim according to claim 6, characterized in that the gear box assembly (9, 109) providing cause nut (13, 113) to move a distance along the drive in the distal direction during injection, is smaller than the distance (19, 119) moves from the injection button.
8. 按照前述权利要求任何一项所述的注射装置,其特征在于, 活塞杆(4, 104)上的附加的纵向延伸轨道(4b, 104b)是成螺旋形地设置的,从而在活塞杆(4, 104)上形成第二螺紋。 8. The injection device of any preceding claim wherein one, characterized in that the additional longitudinally extending track (4b, 104b) of the piston rod (4, 104) are helically arranged, so that the piston rod (4, 104) is formed on the second thread.
9. 按照权利要求8所述的注射装置,其特征在于,活塞杆(4, 104)上的第一螺紋(4a, 104a)和纵向延伸的轨道(4b, 104b )是反向设置的。 9. An injection device according to claim 8, characterized in that the first thread (4a, 104a) and a longitudinally extending track (4b, 104b) of the piston rod (4, 104) are oppositely disposed.
10. 按照权利要求8或9所述的注射装置,其特征在于,联接部件(25 )具有螺紋(28, 128 )并且以螺紋连接方式与设置在壳体(1)上的螺旋状螺紋(37, 137)接合,壳体(1)的螺紋(37, 137)具有基本上与活塞杆(4, 104)上的附加的纵向延伸轨道(4b, 104b) 的螺距相应的恒定螺距。 10. An injection device according to claim 8 or 9, characterized in that the coupling member (25) has a thread (28, 128) and is provided with a threaded connection with the housing (1) of the helical thread (37 , 137) engaging the housing (1) threads (37, 137) having a substantially longitudinally extending rail attached (4b, 104b) of the piston rod (4, 104) on the constant pitch corresponding to the pitch.
Description  translated from Chinese

注射装置技术领域本发明涉及具有活塞驱动部件的注射器,该活塞驱动部件用于在药管内接合并移动活塞,借助该活塞驱动部件,可以在剂量设定期间通过沿着活塞驱动部件旋转螺母来设定剂量,并且其中可以通过将螺母驱动到它的初始位置来排出设定剂量。 Injection Technical Field The present invention relates to a syringe having a piston drive member, the piston driving means in the cartridge for engaging and moving the piston by means of the piston driving means, during the rotation through the nut member along the piston drive may be provided to set the dose dosing, and which can be driven by a nut to its initial position to expel a set dose. 背景技术在EP327910中介绍了一种采用上面介绍的剂量设定和注射方案的堪称经典的注射笔。 BACKGROUND introduced a classic using the above described dose setting and injection protocol in EP327910 the injection pen. 通过在这只注射笔上设定剂量,将形成注射按钮的管状构件沿着螺紋活塞杆旋拧出一段距离,该距离相当于必须要将所述活塞杆移动到来注射设定剂量的距离。 By setting the only dose injection pen, a tubular member forming an injection button is screwed along the threaded piston rod a distance, which distance corresponds to the distance necessary to move a set dose of the arrival of the injection rod. 管状构件简单地具有螺母的形态,在剂量设定期间将该螺母旋拧离开止挡件,并且在注射期间将该螺母按压回到与所述止挡件紧贴的位置上,并且施加在按钮上的力直接传递到封闭注射器中的安瓿一端的活塞上,该安瓿包含要注射的药剂。 The tubular member having a simple shape nut during dose setting nut screwed leave the stopper and the nut during injection presses back and close the stopper position, and applied to the button on the force is transmitted directly to the ampoule closed at one end of the syringe plunger, the ampoule containing the drug to be injected. 在将该活塞按压到安瓿中时,将药剂经由穿过封闭物安装在安瓿另一端上的针头压出。 When the piston is pressed into the ampoule, the agent via a needle through the closure is mounted on the other end of the ampoule is pushed out. 随着时代的发展,越来越想要在安瓿中储存更大剂量,典型地是3毫升而不是不是1.5毫升。 With the development of the times, more and more we want to store larger doses in ampoules, typically 3 ml instead of instead of 1.5 ml. 由于不太适宜将注射器制作得更长,因此另辟蹊径为安瓿制订了更大的直径,即,将活塞面对安瓿中药剂的面积加倍,结果造成施加在活塞上的力也加倍了,这样才能在安瓿内部提供与以前一样的压力。 Because not suitable syringe made more long, so another way to develop a greater diameter ampoule, namely, the piston face area ampoules agents doubled, resulting in the force exerted on the piston also doubled, so as to in ampules provide internal pressure as before. 此外,注射一个单位药剂活塞所要移动的距离减半了。 In addition, a unit dosage injection piston to be moved from the halved. 这种发展并非很受欢迎,因为尤其是手指力量较少的用户按压注射按钮有一定困难,这个问题在仍然使用较细的针头来减小注射的疼痛感的时候会更为严重。 This development is not very popular, especially finger strength because fewer user presses the injection button has been difficult, the problem still using smaller needles to reduce the sense of pain when injected will be more serious. 而且,在按钮的运动相当小的情况下,原本就很难感觉到是否移动了按钮,并且在从3ml安瓿中注射一个单位的时候,活塞(并且随之是注射按钮)必须仅仅移动大约O.lmm。 Further, in the motion of the button relatively small, it is difficult to feel whether the original button is moved, and the injection from an ampoule 3ml unit when the piston (and subsequently injection button) must be moved only about O. lmm. 因而,希望在注射按钮和活塞之间有传动机构,从而使得按钮具有比活塞大的行程。 Accordingly, it is desirable between the injection button and the piston has a drive mechanism, so that the button has larger than the piston stroke. 通过这一传动机构,使得注射按钮的运动量更大,并且施加在注射按钮上的力相应地得到了减小。 Through this transmission mechanism, so that the injection button more exercise, and applying a force on the injection button has been reduced accordingly. 在EP608343中,传动机构是通过这样的实际情况获得的:剂量设定部件是沿着具有大齿距螺紋的心轴旋拧出的。 In EP608343, the actuator is obtained by this situation: the dose setting member along with a large pitch threaded spindle screwed out. 当沿着所述剂量设定部件的轴向向回按压所述剂量设定部件时,螺紋将会引发所述剂量设定部件旋转,这一旋转经由连接机构传递到小螺距的驱动螺母上,驱动螺母将会迫使不随螺紋旋转的活塞杆前进。 When the dose setting member along the axial direction to press back the dose setting member, the thread will trigger the dose setting member is rotated, the rotation transmission via a link mechanism to the small pitch of the drive nut, drive nut will force does not change with the rotation of the threaded rod forward. 在W099/38554中给出了类似的传动机构,其中在剂量设定部件的外表面上切出大螺距的螺紋并且使该螺紋与圆柱形外壳内侧上的配套螺紋接合。 It gives a similar drive mechanism in W099 / 38554, in which the outer surface of the dose setting member cut a big pitch thread and make the thread and matching threads on the inside of the cylindrical housing engagement. 不过,借助这种类型的传动机构,要有相对较大的表面滑过彼此,以致于因为滑动面之间的摩擦而损失了大部分的转换得来的力。 However, with this type of transmission, it has a relatively large surface over another, so that the friction between the sliding surfaces since lost most of the power conversion come. 因此,使用相互接合的齿轮和齿条的传统传动机构并非很好的选择。 Therefore, the use of rack and pinion engaged with each other in the conventional power transmission mechanism is not a good choice. 从W096/26754中了解到一种注射装置,其中两个整合在一起的齿轮分别接合固定在外壳中的齿条和活塞内部的齿条。 From W096 / 26754 learned that an injection apparatus in which two gears are joined together in the housing of the rack and the rack inside the piston. 当活塞在外壳内沿轴向移动时,这个活塞内部的齿条能够驱动第一个齿轮,以使得另一个一体齿轮沿着外壳内部的固定齿条移动。 When the piston to move axially within the housing, the piston can be driven inside the first rack gear, so that the other one is moved along the gear rack fixed inside the housing. 从而使该齿轮沿着活塞运动的方向移动,但是比活塞移动的距离短,并且一体齿轮的这一轴向移动经由包围所述齿轮的外壳传递到活塞杆,该活塞杆将安瓿的活塞进一步压入这个安瓿。 So that the gear is moved along the direction of movement of the piston, but shorter than the distance the piston moves, and the axial movement of one of the housing enclosing the gear via a gear is transmitted to the piston, the piston rod will be further pushed ampule into the ampoule. 不过,活塞内部的齿条是设置在所述活塞内部的多个轴向齿条之一。 However, the internal piston is one of a plurality of rack axial racks provided inside said plunger. 这些齿条之间交替夹着无齿的凹槽,这些凹槽使得活塞能够在第一个齿轮不与这个活塞内的齿条接合的情况下实现轴向移动。 Alternate grooves sandwiched between the rack toothless, these recesses so that axial movement of the piston can be achieved in the case of the first rack gear does not engage the piston. 提供这种结构是为了使得活塞能够在设定剂量的时候沿着朝向外壳之外的方向运动。 This structure is provided so that the piston can be set to dose when the housing along the direction of movement toward the outside. 当旋转活塞来设定剂量时,它在第一个齿轮经过无齿凹槽的情况下的一部分旋转 When the rotary piston to set the dose, it passes without tooth groove portion of the rotation in the case of the first gear

期间向外移动一段与一个单位相应的距离,此后第一个齿轮接合齿条之一,从而能够注射所设定的单位,或者可以继续进行旋转,以使得第一个齿轮经过下一个凹槽,在经过下一个凹槽期间,设定剂量又增加了一个单位,如此继续,直到设定了所需单位数的剂量。 Moving outwardly during a period corresponding to one unit of distance, after which one of the first gear engaging the rack, it is possible to set the injection unit, or may continue to be rotated, so that the first gear after the next recess, After a recess in the next period, it added a set dose units, and so on until the set number of units required dose. 这种构造的缺点在于,相互交错的齿条和齿轮的齿必定彼此进入接合状态和脱离接合状态,具有碴碰的固有危险。 The disadvantage of this configuration is that interlaced rack and pinion teeth must engage each other into the state and the disengaged state, have an inherent risk of ballast touch. 由于沿着活塞的内表面仅能放置少数几条由中间无齿凹槽分开的齿条,因此在360。 Because along the inner surface of the piston is placed only a few few toothless groove separated from the middle of the rack, so the 360. 旋转期间仅能实现少数几次增加。 During rotation only added a few times. 在美国专利US6663602中,公开了一种注射装置,其中在注射按钮和活塞杆之间采用了直接传动机构,即,避免了旋转移动到线性运动和线性运动到旋转运动的过快转化的传动机构。 In U.S. Patent No. US6663602 discloses an injection device, wherein between the injection button and the piston rod using direct transmission, i.e., avoiding the rotational movement of the drive mechanism to linear movement and linear movement to rotational movement of the rapid transformation of . 美国专利US6663602中给出的注射装置包括:外壳,在该外壳中有带有第一螺距的螺紋的活塞杆,该活塞杆不可旋转,但是可沿纵向位移的得到引导;螺母,该螺母接合活塞杆的螺紋,可以沿着带螺紋活塞杆将该螺母旋拧离开外壳中的预定位置,以设定剂量, 并且在注射设定剂量时可以将该螺母带着活塞杆一起压回到所述预定位置;剂量设定部件,可以在外壳内沿着第二螺距的螺紋向外旋拧该剂量设定部件,以将注射按钮与其一起从外壳的近端末端提升起来。 U.S. Patent US6663602 injection device given comprising: a housing, a piston rod having a first thread pitch in the housing, the piston rod can not rotate, but can be guided along the longitudinal displacement; a nut engaging piston The threaded rod may be threaded along the rod nut is screwed away from a predetermined position in the housing to set a dose, the dose setting and injection the nut can be pressed together with the piston rod back to the predetermined position; dose setting member may be screwed outward in the housing of the dose setting member along the second pitch threads, therewith to lift up the injection button from the proximal end of the housing. 这种注射装置配备有传动箱,该传动箱提供注射按钮和螺母相对于外壳的轴向运动之间的传动,这一传动具有与所述第二和第一螺距的比值相应的传动比。 Such an injection device is equipped with a gear box, the gear box providing injection button and the nut relative to the axial movement of the drive between the housing, the drive having a ratio of the first and second pitch corresponding to the gear ratio. 虽然广义地认为是现有技术,但是美国专利US6663602中公开的注射装置因为在设定剂量期间起作用的线性传动系统的构造原理而存在着严重的机械限制。 While broadly it considered to be art, but the injection device disclosed in U.S. Patent US6663602 during construction principles as set dose linear drive system works and there is a serious mechanical constraints. 按照美国专利US6663602的注射装置, 螺母/活塞杆组件的长度会通过沿着活塞杆上的螺紋旋转螺母而在剂量设定期间增长。 U.S. Patent US6663602 according to the length of the injection device, the nut / rod assembly will pass along the threaded rod on the rotation of the nut and growth during dose setting. 在剂量设定期间,螺母和注射按钮的线性位移是相关联的,从而在螺母和注射按钮的运动之间会存在一定比例,该比例是由传动箱的传动比给出的。 During dose setting, the linear displacement of the nut and the injection button is associated, so that there will be a certain proportion between the movement of the injection button and the nut, the ratio by the gear ratio of the transmission case given. 由于在剂量设定期间螺母相对于活塞杆受到旋转限制,因此螺母的平移对应于活塞杆的平移,并且 Due to restrictions with respect to the piston rod by the rotation, and therefore corresponds to the piston rod nut translation translation during the dose setting nut, and

因此最终对应于所执行的药物剂量。 Therefore, the dose corresponds to the final execution. 由于齿轮是该构造整体的一部分,并且由于仅能够将该齿轮设计成具有一定的传动比,因此齿轮对可获得的注射按钮运动相对于活塞运动的比值造成了重要约束。 Because the gear is integral part of the structure, and because only the gear can be designed to have a certain ratio, and therefore gears available injection button relative to the movement of the piston causes the ratio of a major constraint. 由于活塞杆的运动与所执行的药物剂量之间直接成比例,因此同一个注射器不能很容易地适应于不同的药物。 Since directly proportional movement between the piston rod and the dose performed, the same syringe can thus be easily adapted to different drugs. 虽然可以通过改变线性齿轮的传动比来实现适应性,但是这种解决方案一般来说是很复杂的并且意味着要全部重新设计注射器。 Although it is possible by changing the transmission gear ratio to achieve adaptive linear, but this solution is complex and generally means completely redesigned syringe. 发明内容美国专利US6663602中公开的注射装置包括螺母在剂量输送期间保持旋转固定的剂量设定和注射机构。 SUMMARY OF THE INVENTION The injection device disclosed in U.S. Patent No. US6663602 includes a nut maintained during dose delivery rotation of the fixed dose setting and injection mechanism. 不过,按照本发明,螺母在剂量输送期间也可以相对于壳体旋转。 However, according to the present invention, the nut during dose delivery with respect to the housing and to be rotated. 按照本发明的一个方面,该注射装置包括:a. 用于剂量设定和注射机构的壳体,该壳体具有近端末端和远^^^" ,b. 可旋转的剂量设定部件,c. 可沿轴向位移的活塞杆,该活塞杆具有第一螺紋和附加的纵向延伸轨道,d. 壳体上的中心开口,用于接合活塞杆的附加的纵向延伸轨道, 这样在活塞杆的轴向平移期间引导活塞杆的角运动,e. 螺紋螺母,该螺紋螺母接合活塞杆的第一螺紋,该螺母在剂量设定期间可转动地锁定在剂量设定部件上,f. 旋转联接机构,该旋转联接机构具有联接部件,该联接部件能够沿轴向从第一位置位移到第二位置,该旋转联接机构在剂量设定期间允许螺母相对于联接部件的角运动,同时在注射期间防止螺母和联接部件之间发生角运动。联接部件与壳体可旋转地联接,从所述第二到所i第二位、置的二向位移的至少一部)期间旋转、。 According to one aspect of the present invention, the injection device comprising:. A dose setting and injection mechanism for a housing, the housing having a proximal end and a distal ^^^ ", b rotatable dose setting member. c. Non along axial displacement piston rod having a first thread and an additional longitudinally extending track, d. the center of the housing opening for additional longitudinally extending rail engaging rod so that the piston rod the guide rod during axial translation of angular movement, e. threaded nut, the threaded nut threadedly engaged first piston rod, the nut is rotatably locked during dose setting the dose setting member, f. rotary coupling means, coupled to the rotating mechanism has a coupling member, the coupling member can be displaced in the axial direction from the first position to the second position, the coupling of the rotation during dose setting mechanism allows angular movement of the nut relative to the coupling member, while during injection prevent angular movement between the nut and the coupling member. The coupling member is rotatably coupled to the housing, the second, the second rotating position from the second to the i to at least one) during the displacement.

按照这种构造,可以获得注射按钮行程相对于活塞杆行程的延长或缩短。 According to this configuration, the stroke can be obtained with respect to the injection button to extend or shorten the stroke of the piston rod. 此外,由于这种构造意味着剂量设定部件对于所要注射的给定剂量的旋转速度会发生改变,因此可以获得具有不同布局的剂量刻度读数。 Furthermore, since this configuration means that the dose setting member to be injected for a given amount of the rotational speed change occurs, it is possible to obtain a dosage scale reading different layouts. 这样,可以获得连续数字之间的距离增大的刻度读数, 这种读数提供了增大刻度读数标签的字体大小的可能。 Thus, the distance can be obtained between the consecutive numbers increasing scale reading, this provides increased reading scale reading tag font size is possible. 而且,这种构造提供了精调传动比的可能,如果注射装置是这样构成的。 Furthermore, this configuration provides a fine adjustment of the transmission ratio may, if the injection device is thus configured. 按照本发明的第二个方面,剂量设定部件由于该剂量设定部件相对于壳体的旋转而能够沿轴向位移,同时联接部件与剂量设定部件相联接,从而剂量设定部件的轴向位移基本上对应于联接部件的轴向位移。 According to a second aspect of the present invention, since the dose setting member dose setting member is rotated relative to the housing and can be displaced in the axial direction, while the coupling member is coupled with the dose setting member, whereby the dose setting member axis displacement substantially corresponds to the axial displacement of the coupling member. 按照本发明的第三个方面,联接部件具有螺紋并且以螺紋连接方式与设置在壳体上的螺旋状螺紋接合,壳体的螺紋具有恒定螺距。 According to a third aspect of the present invention, the coupling member is threaded and is in threaded connection with the housing provided helical thread engaging the thread of the housing having a constant pitch. 按照这个方面,获得了非常简单的解决方案。 According to this aspect, access to a very simple solution. 按照本发明的第四个方面,联接部件具有螺紋,该螺紋接合设置在壳体上的纵向延伸轨道,其中纵向延伸轨道沿着该轨道的延伸方向具有变化的螺距。 According to a fourth aspect of the present invention, the coupling member is threaded, the threaded engagement is provided on the housing longitudinally extending rail, wherein the longitudinally extending track has a varying pitch along the extending direction of the track. 按照这个方面,剂量设定部件的旋转相对于各种不同的具体剂量选择是非线性的。 According to this aspect, rotation of the dose setting member with respect to various specific dose selection is non-linear. 这样,可以获得具有非线性刻度的剂量设定部件,例如,可以为要注射的较小剂量提供步长比较大剂量的刻度步长大的刻度。 Thus, the scale can be obtained non-linear dose setting member, for example, can provide a relatively large dose of step scale step size scale of smaller doses to be injected. 这意味着低范围可注射剂量内的可分辩性得到了提高。 This means that in the low dose range can differentiate has been enhanced. 而且,壳体提供具有相对于所要注射的具体药量为非线性的行程的注射按钮,例如,对于较小剂量,具有与美国专利US6663602中给出的解决方案相比更长的行程。 Moreover, with respect to the housing to provide a specific amount of the drug to be injected is nonlinear stroke injection button, e.g., for a smaller dose, U.S. Patent No. US6663602 has given a longer stroke compared to solutions. 按照本发明的第五个方面,旋转联接机构包括增量反馈机构,该增量反馈机构在剂量设定期间提供与剂量体积相应的增量咔哒声(click)。 According to a fifth aspect of the present invention, the rotary coupling mechanism includes an incremental feedback mechanism, a feedback mechanism in the delta during the dose and dose volume provided corresponding incremental clicks (click) settings. 这个方面提供了针对各个啼哒声对剂量设定转轮相对于壳体部分的旋转运动量进行轻松调节的方法。 This aspect provides a clicking sound for each sings dose setting wheel to rotate relative to the housing portion of the exercise method for easy adjustment. 与第三个方面相结合, 剂量设定转轮或剂量设定刻度上数字之间距离的增大和减小并且因此各个呻哒声的旋转次数可以通过选择壳体上与联接部件螺紋接合的螺紋的具体螺距来改变。 Combined with a third aspect, the dose setting or dose setting wheel to increase and decrease the distance between the numbers on the scale and therefore each groan rattled number of revolutions can be threaded through the choice of housing and the threaded engagement of the coupling member Specific pitch to change. 通过改变轨道沿着该轨道延伸方向的倾 Dip extension direction along the track by changing the track

斜度,可以以非线性方式改变每次呼哒声的旋转次数。 Slope, you can change the number of rotations in a nonlinear manner clicking sound of each call. 按照本发明的第六个方面,注射按钮可操作地与传动箱组件相连接,该传动箱组件将注射按钮的轴向运动与螺母的轴向运动联系起来。 According to a sixth aspect of the present invention, the injection button is operatively connected to the gear box assembly, the axial movement of the gear box assembly axial movement of the injection button and the nut linked. 注射按钮和螺母之间运动的传动可以借助传动箱来获得,该传动箱包括:至少一个由连接件承载的齿轮,该连接件从传动箱中伸出,该连接件可沿纵向位移但是不可相对于所述传动箱旋转,并且该连接件与螺母形成一体;与传动箱的第一部件形成一体的第一齿条,该部件可旋转但是不能相对于壳体沿着纵向位移;和第二部件, 该第二部件承载着从所述传动箱中伸出的第二齿条,第二齿条可纵向位移但是不能相对于所述第一部件旋转,并且与注射按钮相接, 以随着所述按钮的纵向运动而运动,至少一个齿轮分别接合第一和第二齿条,并且具有能够按照所提到的第二齿条的纵向运动与连接件相对于壳体的传动比提供将第二齿条的纵向运动转换成连接件的纵向运动的传动的尺寸,所述传动比基本上对应于所述第二与所述第一螺距的比值。 Movement between the injection button and the nut drive can be obtained by means of the transmission case, the gear box comprising: at least one connecting member carried by the gear, the connecting member protrudes from the transmission case, the connector member longitudinally relative displacement but not rotating said gearbox, and the connecting member is formed integrally with the nut; a first rack member and the first member of the transmission case formed integrally rotatable but not longitudinal displacement relative to the housing; and a second member , the second carrying member extending from said second rack gear box, the second rack but not longitudinally displaced relative to said first rotary member, and is in contact with the injection button in order with the said longitudinal movement buttons and movement, at least one gear respectively engage the first and second rack, and has referred in accordance with the second rack longitudinal movement of the connector relative to the transmission housing than to provide a second longitudinal movement of the rack is converted into the transmission size of longitudinal movement of the connecting member, substantially corresponding to the gear ratio of the second ratio with the first pitch. 在这样的装置中,仅仅需要由具有大螺距的螺紋转换驱动剂量设定部件所需的力,而将在注射时移动活塞所需的力通过具有恒定不变接合的齿轮和齿条的传统传动机构传递到所述活塞。 In such an apparatus, only we need to convert the thread pitch of the drive member having a large dose of the force required to set, and the force required to move the piston through a conventional transmission having a constant gear and the rack engaging at the time of injection transmitting means to said piston. 在本发明的第七个方面中,活塞杆配备有针对螺母沿着所述活塞杆的螺紋进行的运动的止挡件,从而形成了容量完结止挡件。 In a seventh aspect of the present invention, the piston rod is equipped with a stopper for stopping movement of the nut along the threads of the piston rod, thereby forming a capacity end stopper. 这样, 以经典的方式提供了剂量设定限制器,这种方式没有额外的部件来防止剂量设定值超出安瓿中余留的液体量。 Thus, in the classic manner of a dose setting limiter, no additional components in this way to prevent the dose setting value exceeds the amount of liquid remaining in the ampoule. 按照本发明的第八个方面,活塞杆上的附加的纵向延伸轨道是成螺旋形地设置在活塞杆的外表面上的,从而在活塞杆上形成第二螺紋。 According to an eighth aspect of the present invention, additional longitudinally extending track on the piston rod is helically disposed in the outer surface of the piston rod, thereby forming a second thread on the piston rod. 通过以螺旋方式形成这个轨道,活塞杆由于该活塞杆相对于壳体的轴向位移而发生旋转。 By forming the track in a spiral manner, since the piston rod with respect to the axial displacement of the housing while rotation occurrence. 通过在注射期间旋转活塞杆和联接部件一个类似的角度,可以设定更小或更大的每次呻哒声对应的药剂容量,并且在活塞杆和螺母之间仍然有EOC (容量完结)止挡件。 By rotation of the piston rod during the injection and the coupling member of a similar angle, you can set a smaller or larger groan rattled capacity corresponding to each agent, and between the piston rod and nut still has EOC (end capacity) only stopper. 如本文中所使用的,术语"药物输送装置"按照本发明应该指的 As used herein, the term "drug delivery device" according to the present invention should refer to

是单一剂量、多剂量、可抛弃或可重新利用的设计成用于给予选定剂量的医疗产品(例如,胰岛素、生长激素、低分子量肝素和它们的同功异质体和/或衍生物等),最好是多次选择的剂量的装置。 A single dose, multiple doses, disposable or reusable is designed for administering the selected dose of medical products (for example, insulin, growth hormone, low molecular weight heparin, and their work with heterogeneous and / or derivatives ), preferably multiple dose device of choice. 所述装置可以具有任意形状,例如小盒或钢笔型的。 The device may have any shape, e.g., capsule or pen-type. 可以通过机械(根据需要采用手动方式)或电子驱动机构或者储能驱动机构(比如弹簧等)来提供剂量输送。 It can be mechanical (as required manually) or electrical drive mechanism or stored energy drive mechanism (such as springs, etc.) to provide a dose delivery. 可以通过手动机构或电子机构提供剂量选择。 Dose selection may be provided through a manual mechanism or electronic mechanism. 此外,所述装置可以包含设计成用来监视生理性状(比如血糖水平等)的零部件。 In addition, the device may contain designed to monitor physiological traits (such as blood glucose levels, etc.) components. 此外,所述装置可以包括针头或可以是没有针头的。 Further, the device may comprise a needle or may be needle without. 具体来说,优选实施方式,术语药物输送装置应当指的是具有机械和手动的剂量输送和剂量选择机构的可丟弃的多剂量钢笔型装置,这种装置是为了由没有受过正规医疗训练的人(比如病人) 定期使用而设计的。 Specifically, the preferred embodiment, the term drug delivery device shall mean a multi-dose pen-type device having mechanical and manual dose delivery and dose selection mechanism may be discarded, this device is made to no formal medical training people (such as patient) designed for use on a regular basis. 最好,药物输送装置是注射器型的。 Preferably, the drug delivery device is a syringe-type. 术语"壳体"按照本发明应该最好是指具有内螺紋和外螺紋的外部壳体("主壳体"、"主体"、"壳")或内部壳体("内主体","插入件")。 The term "housing" according to the present invention should preferably refers to the outer shell having an internal thread and external thread ("main housing", "body", "shell") or interior housing ("inner body", "insert member "). 可以将壳体设计成能够实现药物传输装置或者它的任何机构的安全、正确和舒适抓握。 The housing may be designed to enable safe drug delivery device or any of its institutions, proper and comfortable grip. 通常,将其设计成通过限制对污染物(比如液体、灰尘、污垢等)的暴露来封装、固定、保护、引导和/或接合药物输送装置的内部零部件(例如,驱动机构、药瓶、活塞、活塞杆)。 Typically, it is designed by limiting the exposure to contaminants (such as liquid, dust, dirt, etc.) to the package, fixing, protection, guidance and / or engage the internal parts of the drug delivery device (e.g., the drive mechanism, bottle, piston, piston rod). 一般来说,壳体可以是管状或非管状的一体的或者多部分的零部件。 In general, the housing may be a part or multi-tubular or non-tubular parts integral. 通常,外部壳体用于封装可以从中配发多个剂量的理疗产品的药瓶。 Typically, the outer housing for encapsulation can learn allot more doses of therapeutic product vial. 不过,药瓶可以与壳体直接相接,以致部分地或全部处于壳体之外。 However, the bottle may be directly in contact with the housing, such that the partially or completely in the outside housing. 术语"接合"按照本发明应当具体指的是驱动机构/药物输送装置的两个或多个零部件的相互锁定,例如,花鍵或螺紋连接,最好是零部件的螺旋状螺紋的相互锁定("以螺紋连接方式接合")。 The term "engagement" should be specified in accordance with the present invention refers to the drive mechanism / interlocking of two or more components of the drug delivery device, such as a spline or thread connection, preferably a helical thread of interlocking parts ("In threadably engaged"). 术语" 接合"包含使用联接以螺紋连接方式接合的螺紋的中间零部件。 The term "bonding" comprises using connecting thread threadably engaged intermediate components. 术语"螺紋"按照本发明应当最好指的是位于药物输送装置的零部件的内表面和/或外表面(,,内螺紋"和/或"外螺紋")上的全部或部分螺紋,例如,螺旋线凸棱/凹槽,通常具有螺旋性质或者包括线性倾斜部分,具有基本上为三角形或正方形或者圆形截面的形状,设计成用于实现零部件之间的连续自由旋转和/或轴向运动。根据情况, 可以将螺紋此外设计成用于防止某些零部件在一个方向上的旋转或轴向运动。术语"剂量设定部件"按照本发明应该指的是横截面基本上为圆形的基本上为管状的零部件,具有:a)内螺紋和外螺紋二者,或b) 内螺紋,或c)外螺紋。可以将剂量设定部件设计成用来指示所选择的可排出产品的剂量。这可以通过利用标记、符号、数字等来实现, 例如印刷在剂量设定部件或测距计的外表面上,等等。而且,也可以使用单独的剂量刻度,包括机械的或电子显示装置。术语"导程"按照本发明应当最好是指螺母在一个完整旋转中应当推进的轴向距离;最好"导程"应当指的是驱动机构的具有螺旋状螺紋的零部件(即,剂量设定部件、螺母、活塞杆等)在一次旋转期间前进的轴向距离。因此导程是相关零部件螺纹螺距的函数。术语"螺距"按照本发明应当最好是指平行于螺旋状螺紋的轴向测量的螺旋状螺紋上的连续轮廓之间的距离。术语"活塞杆"按照本发明应该指的是适合于穿过壳体/在壳体之内操作的零部件,它设计成用来为了排出/给予可注射的产品而转移穿过药物输送装置/在药物输送装置内的轴向运动,最好是从螺母转移到活塞。所述活塞杆可以弹性的或非弹性的。它可能是简单的杆、 导螺杆,等等。"活塞杆"按照本发明应当此外还指具有非圃形横截面并且最好具有一个或多个部分或完全沿着其长度延伸的螺紋的零部件。它可以由本领域技术人员熟知的任何适当的材料制成。术语"增量反馈机构"按照本发明应该是指提供在多个不连续递增步长中出现的剂量设定值的机构,例如,为每次设定一个国际单位提供一次增量吵哒声,增量反馈机构最好提供可由操作注射笔的用户感觉到或听到的可触摸到的或可听到的咔哒声。附图说明 All or part of the thread the term "thread" in accordance with the present invention should preferably refer to the inner surface of the drug delivery device components located and / or outer surface (,, internal thread "and / or" external thread ") on, for example, , spiral rib / groove, having a generally helical nature or comprises a linear inclined portion, having a substantially triangular or square or circular cross-sectional shape designed to achieve continuous free rotation between the components and / or the shaft to sports. As the case may be threaded Moreover designed for preventing rotation or axial movement of certain components in one direction. The term "dose setting means" in accordance with the present invention should refer to the substantially circular cross-section a substantially tubular-shaped part, having:. a) both the internal thread and external thread, or b) an internal thread, or c) an external thread of the dose setting member may be designed to indicate a selected can be discharged The dose of the product. This can be through the use of markers, symbols, numbers, etc. to achieve, for example, printing the outer surface of the dose setting member or the distance meter, etc. Also, you can use a separate dosage scale, including mechanical or The electronic display device term "lead" according to the present invention shall mean the axial distance a nut is preferably in a complete rotation should advance; best "lead" shall mean a component having a helical thread of the drive mechanism (That is, the dose setting member, nut, rod, etc.) during a rotation of the axial distance forward. Therefore lead is a function of the relevant parts of the thread pitch. The term "pitch" according to the present invention should preferably refer to parallel continuous helical thread profile axial distance measured between a helical thread on the term "rod" in accordance with the present invention should refer to suitable housing / within the housing of the operating components pass through it designed to discharge to / administering an injectable product transferred through the drug delivery device / axial movement of the medication delivery apparatus, preferably transferred from the nut to the piston. The piston rod may be elastic or nonelastic It may be a simple rod, a lead screw, and the like. "piston rod" according to the present invention shall also refers to a non-garden shaped cross-section and preferably has one or more portions or threads extending along its full length Any suitable material components. It can be well known to be made by those skilled in the art. The term "incremental feedback mechanism," according to the present invention refers to the agencies should appear in a plurality of discrete incremental step in the dose setting value, For example, for each set of international institutions to provide an incremental noisy clatter, incremental user feedback mechanism is preferably provided by the operation of the injection pen can feel or hear or touch audible clicks. attached The figure below illustrates

下面,将参照附图对本发明进行更加详细地介绍,其中附图1示意性地表示按照本发明的注射装置的剖面图,和附图2示意性地表示沿着附图1中的线I--I截取的传动箱的剖面图,附图3表示按照本发明的注射装置的另一种实施方式的剂量设定部分中的纵向剖面图,附图4表示与附图3中的视图垂直的纵向剖面图,附图5表示附图3和4中所示的装置的分解图,附图6a表示按照本发明的一种实施方式的附图5的管状部分105的》丈大图,和附图6b表示现有注射装置的相应部分105的放大图。 Next, with reference to the accompanying drawings of the present invention will be described in more detail, wherein Figure 1 schematically shows a sectional view of the injection device according to the present invention, and the accompanying drawings schematically shows in Figure 1 along line 2 I- -I sectional view taken gearbox, Figure 3 shows a longitudinal section of the set cross-sectional view of another embodiment according to the dose of the injection device of the present invention, and Figure 4 shows a vertical view in Figure 3 longitudinal cross-sectional view, Figure 5 shows an exploded drawing device of FIG. 3 and 4, as shown in the drawings according to figures 6a shows an embodiment of the present invention, a tubular 5 "husband big picture, and attachment portion 105 6b shows an enlarged view of the prior corresponding portion 105 of the injection device. 具体实施方式将附图中所示的装置表示为注射笔,该注射笔具有细长主体,该细长主体具有中心轴。 DETAILED DESCRIPTION The apparatus shown in the drawings is represented as an injection pen, which pen has an elongated body, the elongate body having a central axis. 不过,其它形态也处于本发明的范围之内。 However, other forms are within the scope of the present invention. 在附图l所示的装置中,细长圆柱形壳体1具有间隔壁2,该间隔壁2将壳体分成装纳一剂量设定机构的隔舱和设计成用来安放未示出的安瓿的隔舱3。 L In the apparatus shown in the drawings, the elongated cylindrical housing 1 having walls 2 between the partition wall 2 is satisfied that the housing is divided into compartments mounted a dose setting mechanism and designed to be placed (not shown) ampoule compartment 3. 间隔壁2配备有从中穿过的开口。 The partition wall 2 is provided with an opening therethrough. 另外,间隔壁可以由插入件代替,使该插入件不能相对于壳体1的主结构进行旋转和轴向运动地固定住,所述开口形成在所述插入件上。 Further, partition walls may be replaced by an insert so that the insert can not be relative to the main structure of the housing 1 is rotated and axially movably fixed, said opening formed in said insert. 活塞杆4 穿过开口2b,活塞杆4具有第一螺紋4a和形成在该活塞杆4之内和之上的附加的纵向延伸轨道4b,开口2b配备有与附加的纵向延伸轨道4b配套且接合的一个或者多个凸棱。 The piston rod 4 through the opening 2b, the piston rod 4 has a first threaded 4a and additional longitudinally extending track is formed within the piston rod 4 and above 4b, opening 2b is provided with a longitudinally extending track and additional supporting and engaging 4b one or more ribs. 按照附加的纵向延伸轨道4b和间隔壁2上配套开口2b的具体设计,活塞杆4依照该活塞杆的轴向位移的函数得到旋转引导。 Additional longitudinally extending track in accordance with the partition wall 4b supporting the opening 2b 2 specific design and, in accordance with the piston rod 4 to get the rotational axial displacement of the guide rod function. 为了获得在相对于壳体可旋转地锁定的同时能够沿纵向位移的活塞杆4,将附加的纵向延伸轨道4b形成为平行于活塞杆4的轴线延伸的直线轨道。 In order to obtain rotatably relative to the housing while the locking can be displaced longitudinally of the piston rod 4, the additional longitudinally extending track 4b is formed parallel to the axis of the piston rod 4 extending straight track. 另外,为了获得依照活塞杆4的轴向位移的函数而旋转的活塞杆4,将附加的纵向轨道4b形成为与形成在间隔壁2上的开 Further, in order to obtain the axial displacement of the piston rod 4 in accordance with a function of the rotation of the piston rod 4, an additional longitudinal track 4b is formed as the opening formed in the partition walls 2

口2b内的螺旋凸棱或螺紋配套且接合的螺旋槽或螺紋。 Spiral rib or thread within the port 2b supporting and engaging the spiral groove or thread. 按照注射装置的具体设计,可以将第一螺紋4a和附加的纵向延伸轨道4b设置在活塞杆4的相反两端,第一螺紋4a和附加的纵向延伸轨道4b可以沿着活塞杆4的轴向部分重叠或完全重叠。 An injection device according to the specific design, the first additional thread 4a and 4b disposed in a longitudinally extending track rod 4 opposite ends, a first thread 4a and 4b attached longitudinally extending rails along the axial direction of the piston rod 4 partially or completely overlap. 而且, 可以将螺紋4a设置成具有比附加的纵向延伸轨道4b大的深度,或者反之。 Moreover, you can set the thread 4a 4b larger than the depth of the longitudinally extending rail attached, or vice versa. 在附图1中,螺紋4a和4b和该螺紋开口2b是示意性表示的。 In Figure 1, the thread 4a and 4b and the threaded opening 2b is a schematic representation. 与壳体1同心地,壁2在其朝向远离隔舱3—方的侧面上承载着管状部件5,管状部件5在其与壁2相邻的部分上配备有外螺紋6并且在其自由端上具有圆周凹槽7。 Concentrically with the housing 1, 2 in its wall facing away from the carrying compartments on the sides of the tubular member 5 3- parties, the tubular member 5 is provided at its portion adjacent to the wall 2 and 6 and an external thread at its free end having a circumferential groove 7. 传动箱9上的环形联接部件8接合凹槽7。 Gearbox annular coupling member engaging groove 9 8 7. 通过这种联接,以使得传动箱9能够在壳体内旋转但是不能相对于所述轴向位移的方式将传动箱固定在壳体1中。 In this connection, the transmission case 9 so that the manner to be rotatable but not axial displacement relative to the transmission case 1 is fixed in the housing in the housing. 在传动箱9中,包括两个一体齿轮的齿轮组件套装在轴杆11上, 该轴杆11垂直于两个轴向连接棒12之间的装置的纵轴。 In the gearbox 9, comprising two integral gear gear assembly fits over the shaft 11, the shaft 11 is perpendicular to the longitudinal axis of the rod in both axial connection means between the rod 12. 连接棒12 从传动箱朝向间隔壁2伸出并且与螺母13相连,螺母13接合活塞杆4的第一螺紋4a。 Connecting rod 12 extends from the room next door toward the transmission case 2 and connected to the nut 13, nut 13 engages the first threaded rod 4a 4. 齿轮組件包括具有较大直径的齿轮14和具有较小直径的齿轮16,齿轮14接合齿条15的齿,齿条15在传动箱中得到引导,以沿着装置的纵向发生位移,齿轮16接合附图2中在传动箱9的内壁上沿着该装置的纵向延伸的齿条10。 Gear assembly includes a gear 14 having a larger diameter and a smaller diameter gear 16 having a gear 14 engaging the teeth of the rack 15, the rack 15 is guided in the gear box, along the longitudinal displacement means, the gear 16 is engaged 2 of the drawings the rack on the inner wall of the transmission case 9 extending along the longitudinal direction of the apparatus 10. 具有较小直径的齿轮16可以分成位于齿轮14两侧的两个齿轮,并且传动箱9内壁上的齿条可以具有没有任何齿的纵向凹槽,以便为齿轮14腾出空间。 Gear 16 having a smaller diameter can be divided into a gear located on both sides of the two gears 14, and the rack on the inner wall of the gearbox 9 may have a longitudinal recess without any teeth to make room for the gear 14. 安装在壳体2内的管状剂量设定部件17在一端配备有与管状部件5的外螺紋6配套且接合的内螺紋,并且在其另一端具有形成剂量设定按钮18的直径扩大的部分。 Mounted in the housing 2 of the tubular dose setting member 17 at one end of the tubular member is provided with an external thread 5 and 6 supporting the engaging internal thread, and having a diameter forming a dose setting button 18 of the enlarged portion at the other end. 由于与螺紋6接合,可以将剂量设定部件17旋拧入和旋拧出壳体,以在壳体l上的未示出的窗口中显示出其外表面上的未示出的螺旋刻度上的数字。 Due to the engagement with the thread 6 may be dose setting member 17 is screwed in and screwed out of the housing to the window (not shown) on the housing l is not shown in the exhibit spiral scale on its outer surface numbers. 深杯形部件上的底部19形成注射按钮,该深杯形部件具有装配在剂量设定部件17中并且围绕着传动箱9的管状部分20。 The bottom of the cup-shaped member 19 is formed on the deep injection button, the deep cup-shaped member having dose setting member 17 is fitted in and around the gear box of the tubular portion 20 9. 剂量设定部件17和杯状部件之间的联接构件确保将剂量设定部件17的旋转 Dose setting coupling member 17 and the cup-shaped member between the components to ensure the rotation of the dose setting member 17

传递给杯状部件。 Transmitted to the cup-shaped member. 此外,管状部分20的内壁具有由传动箱9上的凸起23接合的纵向凹槽22,从而使得剂量设定部件17的旋转经由杯状部件传递到传动箱9。 In addition, the inner wall of the tubular portion 20 has a longitudinal groove 9 by a projection 23 on the engagement of the transmission case 22, so that rotation of the dose setting member 17 is transmitted to the transmission case 9 via a cup-shaped member. 在杯状部件开口端的边缘,设有V形齿的瓣状体(rosette), 该齿接合联接部件25上的V形齿24的相应瓣状体,该联接部件25 在弹簧26的作用下压靠着杯状部件的边缘,弹簧26压缩在联接部件25没有齿的侧面与处于剂量设定部件17内螺紋的内端的剂量设定部件17内壁上的圏绕台肩27之间。 At the edge of the open end of the cup-shaped member, with a V-shaped teeth of the rosette (rosette), the gear coupling member engages the corresponding V-shaped teeth 24 of rosette 25 on the coupling member 25 against the action of the spring 26 doses against the edges of the cup-shaped member, the compression spring 26 in the side surface 25 without tooth at the dose setting member and the coupling member 17 of the inner end of the set screw rings of the inner wall member 17 between the shoulder 27 around. 联接部件25配备有形成螺紋28 的一个或多个内凸起,螺紋28由管状部件5上的螺紋或轨道37接合, 从而将会在联接部件25相对于壳体沿轴向位移时迫使它旋转。 Coupling member 25 is provided with one or more threads are formed within the projections 28, 28 engaged by a threaded screw or track 37 on the tubular member 5, whereby the coupling member 25 will force it to rotate with respect to the axial displacement of the housing . 可以将轨道37设计成一个沿着该轨道的延伸方向具有恒定螺距的螺旋状螺紋。 It rails 37 can be designed as a helical thread having a constant pitch along the extending direction of the track. 另外,也可以将螺距的布局形成为沿着轨道的延伸方向具有可变的螺距,例如,通过形成具有倾斜的以及不倾斜的直线台阶或弯曲部分的轨道。 Further, the layout pitch may be formed to have a variable pitch along the extending direction of the track, for example, by forming an inclined and not inclined straight line or the stepped portion has a curved track. 将轨道37形成为这样的形状:当用户通过旋转剂量设定按钮18 调整剂量时,剂量设定部件17相对于联接部件25旋转。 The track 37 is formed in such a shape: when the user to adjust the dose setting button 18 by the rotation of the dose, the dose setting member 17 relative to the coupling member 25 is rotated. 这样,建立了^哒发声联接,这种联接方式会在杯状部件边缘上的V形齿借助这个部件的旋转而跨越联接部件25的V形齿的时候制造呼哒的声音,即,提供了增量反馈机构。 Thus, the establishment of a sound connection ^ da, this approach will join in on the edge of the cup member V-shaped teeth clatter of voices calling manufactured by the rotation of the cross member and the coupling member 25 of V-shaped teeth when that is provided Incremental feedback mechanism. 齿条15凸出端上的端头29有游隙地固定在杯状部件的底部上, 介于形成注射按钮的底部19与靠近这一底部的内壁30之间。 Rack 15 on the convex side end 29 there is loosely secured to the bottom of the cup-shaped member is formed between the bottom between the 19 and the injection button near the bottom of the inner wall 30. 齿条借助它的端头通过底部19与端头29之间的弹簧31压靠壁30而固定到位。 Rack ends by means of which the bottom 19 and the end of the spring 31 between the head 29 pressed against the wall 30 and fixed in place. 要设定剂量,需要旋转剂量设定按钮18,以便按照螺紋6沿着近端方向推进剂量设定部件17。 To set the dose, the dose setting button 18 needs to be rotated in order to follow the thread 6 to promote the dose setting member 17 along the proximal direction. 由于存在联接构件21,杯状部件将会随着剂量设定部件17的旋转而运动并且与这个部件同时从壳体1 的末端提升起来。 Because of the coupling member 21, with the cup will be the dose setting member 17 and the movement of the rotating member and simultaneously lifted from the end of the housing 1 and the member. 在剂量设定期间,剂量设定部件17和注射按钮19 各自的轴向位移量取决于螺紋6的螺距、活塞杆4上的第一螺紋的螺距以及传动比。 During dose setting, dose setting member 17 and the injection button 19 each axial displacement depends on the thread pitch. 6, piston rod and the gear ratio of the first thread pitch of 4 on. 而且,如果活塞杆4能够在剂量设定期间移动,则活塞杆4的轴向旋转运动会影响注射按钮的位移量。 Moreover, if the piston rod 4 can move during dose setting, the piston rod 4 in axial rotation displacement amount Games injection button. 通过杯状部件的旋转,其开口端边缘上的V形齿24将会跨越联接部件25的V形齿25,以便为每次单位剂量变化制造声音。 By rotating the cup-shaped member having an open end V-shaped teeth on edge across the coupling member 24 will be V-shaped teeth 25, 25 in order to produce sounds per unit dose changes. 可以通过沿着与增加剂量方向相反的方向旋转剂量设定按钮18来减小过高的设定剂量。 By increasing the dose along with the opposite direction to the rotation of the dose setting button 18 to reduce the high set dose. 当沿着管状部件5上的螺紋6旋拧剂量设定部件时,联接部件25将会由于弹簧26支撑在台肩27上而跟随剂量设定部件沿其轴向的运动。 When the dose along the thread 6 is screwed on the tubular member 5 is set member, the coupling member 25 will be due to the spring 26 is supported on the shoulder 27 and follow the dose setting member is moved along the axial direction. 该弹簧将会使联接部件25的V形齿与杯状部件保持接合状态并且维持联接构件21的接合,联接构件21可以包括接合所述剂量设定按钮18中的内环33上的A形凹槽的杯状部件上的A形凸起32。 The spring will make the coupling member V-shaped teeth and the cup member 25 remains engaged state and maintain the coupling member engagement 21, the coupling member 21 may include engaging the dose setting A button-shaped recess 18 on the inner ring 33 A cup-shaped groove member projection 32. 由于剂量设定部件17在剂量设定期间的轴向位移,联接部件25 也沿轴向发生位移。 Since the dose setting member 17 in axial displacement during dose setting, the coupling member 25 is also displaced in the axial direction. 按照螺紋或轨道28和37的具体设计,在联接部件25沿轴向位移时迫使该联接部件25发生旋转。 According to the specific design of the thread or track 28 and 37, when the axial displacement of the coupling member 25 to force the coupling member 25 is rotated. 在某些实施方式中, 将螺紋37形成为螺旋状螺紋,该螺紋沿着联接部件能够移动的总轴向距离的长度具有恒定螺距。 In certain embodiments, the thread 37 is formed as a helical thread, the length of the threaded coupling member movable along the total axial distance having a constant pitch. 取决于轨道37的旋转方向,与将联接部件保持旋转固定的情形相比,对于每次出现咔哒声,剂量设定按钮18必定要旋转更大或更小的角度。 Depending on the rotational direction of the track 37, as compared with the coupling member rotationally fixed holding case, an angle at each occurrence clicks, the dose setting button 18 must be greater or smaller rotation. 可以为刻度读取布局提供相应的修正,例如,通过使剂量刻度在相邻剂量值之间形成有更大或更小的间距。 Can provide the appropriate correction for the scale reading layout, e.g., by dose dial dose between adjacent values are larger or smaller pitch is formed. 剂量设定按钮18和杯状部件的旋转此外还会通过传动箱上接合所述杯状部件的管状部分20内壁上的纵向凹槽22的凸起23传递到传动箱9。 Dose setting button 18 and the cup-shaped member 20 of the rotary Furthermore longitudinal groove also by the inner wall of the tubular portion of the transmission case engages the cup member 22 on the projection 23 is transmitted to the transmission case 9. 传动箱9的旋转通过连接棒12传递到螺母13,这样使得螺母13在设定剂量的时候沿着活塞杆4的第一螺紋4a推进并且使其提升离开它与壁2相抵靠的位置。 The rotation is transmitted to the transmission case 9 nut 13 by connecting rod 12, so that the nut 13 4a advance and it lifted off it abut the wall 2 position in the set dose when the piston rod 4 along the first thread. 由于剂量是通过移动活塞杆上的螺母13来设定的,该活塞杆操作隔舱3中的未示出的安瓿中的活塞, 因此通过为活塞杆4配备限制螺母13沿着活塞杆4向上运动的止挡件35,能够很容易地构造剂量设定限制器,该剂量设定限制器确保所设定剂量的大小不会超出安瓿中存留的药剂量。 Since the dose is moved by a nut on the piston rod 13 to set the operating rod 3 in the compartment, not shown in the ampule piston to the piston rod 4 so by limiting nut 13 along with the piston rod 4 upward movement stopper member 35, can be easily configured dose setting limiter, which ensure that the set dose setting limiter does not exceed the size of the dose remaining dose ampoules. 由于端头29被限制在杯状部件的底部19和壁30之间的空间内, 因此齿条15随着注射按钮向外拉出。 Since the tip 29 is limited to the space at the bottom of the cup-shaped member 19 and the wall 30 between the rack 15 thus pulled out with the injection button outward. 取决于齿轮组件的具体传动比, Depending on the gear ratio of the gear assembly,

齿条15的向外运动与螺母13的向外运动相应。 Outward movement of the rack 15 and the outward movement of the nut 13 accordingly. 随着螺母13在剂量设定期间的旋转,活塞杆/螺母组件的长度取决于活塞杆/螺母螺紋的相互螺距并且取决于附加的纵向延伸轨道4b的实际设计而伸长。 As the nut 13 is rotated during dose setting, the length of the rod / nut assembly depends on the mutual pitch rod / nut threads and depend on the actual design of additional longitudinally extending elongated orbit and 4b. 通过改变不同螺紋的螺距或传动比,使得活塞杆在剂量设定期间向远端移动、向近端移动或者保持固定不动。 By changing the pitch of the thread or a different transmission ratio, so that the piston rod to move distally during dose setting, move or remain stationary proximally. 理想地,如果在剂量设定期间不想活塞杆4发生轴向运动,则螺紋6和活塞杆上形成的螺紋4a的螺距以及外凹槽6的间距应当恰好与附图2中画出的传动箱的传动比匹配。 Ideally, if you do not want during the dose setting axial movement of the piston rod 4 occurs, the thread 6 4a thread pitch and pitch and outer groove 6 formed on the piston rod should be coincided with the drawings depicted the transmission case 2 The gear ratio match. 不过,构成注射笔的零部件的加工公差可能会导致螺距相对于传动箱9的不希望有的传动比的轻度失配。 However, manufacturing tolerances of the parts constituting the injection pen may result in pitch relative to the transmission case you do not want some slight mismatch ratio 9. 尤其是非常不希望出现活塞杆4在剂量设定期间轻微推进的情形,因为注射装置在剂量设定期间将会排出少量药物。 Especially the highly undesirable situation piston rod 4 during dose setting appears slight advance, because the injection device during dose setting will emit a small amount of drugs. 这种情形可以通过使一个或多个上面提到的螺距与传动箱的传动比失配,以致使活塞杆4在剂量设定期间轻微拉出来避免。 This situation can be achieved by one or more of the above-mentioned pitch with gearbox transmission ratio mismatch, to cause the piston rod 4 slightly pulled out during dose setting avoided. 螺距的失配是通过改变活塞杆4上制作的凹槽4a和螺母13上的相应螺紋的螺距来非常简单的实现的。 Pitch mismatch is produced by varying the piston rod 4 corresponding threaded recess 4a and the nut 13 on the pitch to a very simple implementation. 此外,如果活塞杆上的附加的纵向延伸轨道4b形成为螺旋状螺紋,即,使得活塞杆4能够相对于壳体1 旋转,则在设计该机构时必须考虑这一螺紋连接。 Further, if the additional longitudinally extending track 4b is formed on the piston rod is helical thread, i.e., so that the piston rod 4 relative to the rotation of the housing 1, at the institution must be considered when designing the threaded connection. 按照另外一种可选方案,将注射装置设计成将活塞杆上的凹槽一开始设计成与活塞杆沿轴向对准。 According to another alternative, the injection device designed to be grooves on the piston rod and the piston rod is designed to initially axially aligned. 在组装好的产品原型上,测量活塞杆在剂量设定期的推进量。 In the assembled prototype, measuring rod during dose setting the amount of the advance. 此后,将轴向对齐的凹槽重新设计成螺旋状凹槽,此时活塞杆在剂量设定期间的叠加旋转会补偿加工公差。 Thereafter, the axially aligned groove redesigned into a spiral groove, then superimposed rotation of the piston rod to compensate machining tolerances during dose setting. 按照本发明的一种实施方式,螺紋部件螺距和线性传动相匹配, 从而使得活塞杆在剂量设定期间相对于药瓶缩短了整个线性平移的0%到2%。 According to one embodiment of the present invention, the threaded member and the linear drive to match the pitch so that the piston rod during dose setting with respect to the vial shorten the overall linear translation of 0% to 2%. 在美国专利US6663602中给出的注射装置中可以提供相应的解决方案,该美国专利包含具有联接部件25的注射装置,该联接部件25相对于壳体保持可旋转地锁定。 The injection device is given in U.S. Patent No. US6663602 may be provided in the appropriate solution, which comprises an injection device having U.S. Patent coupling member 25, the coupling member 25 with respect to the housing rotatably holding locked. 对于这种特定的特定注射装置, 能够提供螺紋6或活塞杆4的螺紋与传动箱的传动比的轻微失配,从而使活塞杆4在剂量设定期间轻微拉出。 For this particular specific injection device, capable of providing a threaded screw 6 or the piston rod 4 with a slight mismatch gearbox transmission ratio, so that the piston rod 4 slightly pulled out during dose setting. 在按照本发明的装置中,为了注射设定剂量,通过在底部19上按压来按下注射按钮。 In the apparatus according to the present invention, in order to inject the set dose by pressing the injection button is pressed to the bottom 19. 在按压的初始阶段,使弹簧31压缩,此后压力直接传递到齿条15的端头29上,并且这样传递到齿条15本身上。 In the initial stage of the pressing, the compression spring 31, after which the pressure is directly transmitted to the head end 29 of the rack 15, and thus transmitted to the rack 15 itself. 通过传动箱9,将该力加以转换并且通过连接棒12传递到螺母13上, 该螺母13将会把活塞杆4压入隔舱3,直到剂量设定部件17抵靠住壁2。 By gearbox 9, the force to be converted and transferred to the connecting rod 12 by the nut 13, the nut 13 will be pressed into the compartment of the piston rod 4 3 until the dose setting member 17 abut the wall 2. 该注射按钮运动的初始阶段,杯状部件上的A形凸起32将会从它们与圆环33上的A形凹槽的接合状态中抽出。 The initial phase of the injection button movement, A cup-shaped projection member 32 will be drawn from them with the A ring-shaped groove 33 on the engaged state. 剂量设定部件17 现在可以相对于注射按钮旋转并且在A形凸起32压抵住剂量设定按钮18底部处的台肩34的时候将会旋转。 The dose setting member 17 can now be rotated and the injection button with respect to the A-shaped projection 32 is pressed against the shoulder of the dose setting button 18 when the bottom 34 will be rotated. 仅仅需要足以使得剂量设定部件旋转、以将其自身沿着螺紋6向下旋拧的力,因为要通过传动箱9将进行注射所需的力传递到活塞杆4。 Only needs to be sufficient such that the dose setting member is rotated to its own thread 6 downward along the screwing force, since the transmission case 9 through the required injection force is transmitted to the piston rod 4. 可以将与剂量设定部件同心的螺旋状复位弹簧36安装在这个部件的下端,并且该螺旋状复位弹簧36的一端可以锚定在剂量设定部件17上,而另一端锚定在壁2 上。 The dose can be set with spiral return spring member concentrically mounted on the lower end of the member 36, and one end of the helical return spring 36 may be anchored on the dose setting member 17 and the other end anchored to the wall 2 . 在剂量设定期间,可以使这个弹簧巻紧,从而在剂量设定部件上施加与克服剂量设定部件沿着螺紋6运动的过程中的摩擦力所需的扭距近似相应的扭距,从而用户对注射按钮施加的力仅仅是将活塞杆驱动到安瓿内来注射设定剂量所需的力。 During dose setting, you can make this spring Volume tight, resulting in the dose setting member is applied along the process setting section 6 the movement of the thread friction torque needed to approximate the corresponding torque and overcome the dose, thereby Force applied to the user on the injection button is only the rod driven into an ampoule to inject the set dose the force required. 应当注意,使用仅仅一种大小的齿轮来接合能够相对于传动箱9 移动的齿条15以及不能相对于传动箱移动的齿条10,为可移动的齿条15和承载齿轮的轴杆11的连接件12相对于注射器壳体1的纵向运动提供了2:1的传动比。 It should be noted, with respect to the engaging movement of the transmission case 9 and the rack 15 can not move relative to the rack gear box 10, a movable rack gear 15 and the bearing shaft 11 using only one size gear connecting member 12 relative to the longitudinal movement of the syringe casing 1 provides a 2: 1 ratio. 附图3和4表示使用仅有一种大小的齿轮的实施方式,并且其中为与附图l和2中的部件相应的部件给予了相同的附图标记,只是在这些部件的附图标记前面加上了"l"。 Figures 3 and 4 shows an embodiment using only one size gear, and wherein l and 2 of the accompanying drawings and the components corresponding to given the same reference numerals, but in front of the reference numerals of these components plus on the "l". 出于加工制造的原因,仅仅进行了细小的变化。 For reasons of manufacturing, just made small changes. 所以将间隔壁102和管状部件105制作成两个部分,各个部分通过装置的组装彼此连接,以使得组装好的部分作为一体部件发挥作用。 Therefore, the partition wall 102 and the tubular member 105 made in two parts, each part connected to each other by assembling means, such as an integral part of the assembled members play a role. 同样将剂量设定部件117和剂量设定按钮118做成两个部分,将它们紧固地固定在一起。 Also the dose setting member 117 and the dose setting button 118 made in two parts, they are tightly secured together. 将圆周凹槽107设置为管状部分105自由端上的外凹槽,并且将环形联接部件设置为传动箱部件109上的内巻边108,该巻边接合凹槽107,以在管状部分105和传动箱之间提供可旋转但是不可沿轴向位移的连接。 The circumferential groove 107 is disposed to the outer groove 105 on the free end of the tubular portion, and the annular coupling member disposed within the gear case member 109 Volume edges 108, the side engaging recess Volume 107, to the tubular portion 105 and provided between the gearbox can be rotated but can not be connected axially displaced. 具有接合传动箱上的凹槽123的凸脊122的管状部件120在其上端由按钮119封闭,将通过按压这一按钮119而提供的力从该按钮传递到管状部件120。 Gear box has an engagement recess 122 on the ridge 120 of the tubular member 123 closed at its upper end by the button 119, by pressing the button 119 will provide the force is transmitted from the button to the tubular member 120. 该传动箱由两个外壳构成,这两个外壳合在一起形成安装到管状部件中的圆筒,在管状部件中,这些外壳通过凸脊122和凹槽123 之间的接合而得到引导。 The gearbox housing constituted by two, the two together to form the housing is mounted to a cylindrical tubular member, the tubular member, the housing engaging ridges 122 and grooves 123 between which is guided through. 沿着外壳边缘设置有齿条110和115,彼此面对。 Along the edge of the housing is provided with racks 110 and 115 face each other. 形成传动箱部件109的外壳配备有内巻边108,该内巻边108 接合中央的管状部分105末端上的圆周凹槽107并且承载齿条110。 Forming a gear case member housing 109 is provided with inner edge 108 Volume, Volume of the inner edge 108 engages the circumferential groove 105 on the end of the tubular portion 107 and the center of the rack 110 carries. 另一个外壳可以在管状部件120中沿轴向位移并且形成齿条115。 Another housing to be axially displaced in the tubular member 120 and the rack 115 is formed. 在其从传动箱伸出的外端,承载着齿条115的外壳配备有凸缘140,该凸缘140位于管状部件120承载按钮119的末端上的切口141内,从而这个按钮和管状部件120可以向该装置之内进行这种程度的运动: 齿132和133的接合可以在按钮119抵靠住凸缘140之前松脱开。 At the outer end of its extended from the transmission case, carrying rack is equipped with a flange 115 of the housing 140, the flange 140 is located within the cut end of the tubular member 120 carrying 141 119 on the button, so that this button and the tubular member 120 To this means it can carry out this level of sport: the engagement teeth 132 and 133 can be found in the release button 119 abuts the flange 140 before opening. 管状连接部件112将螺紋活塞杆104与传动箱连接起来。 Threaded tubular connection member 112 to the piston rod 104 connected with the transmission case. 在其接合活塞杆104的末端,连接部件具有螺母113,该螺母具有与活塞杆104的外螺紋104a配套的内螺紋。 At the end of their engagement rod 104, the connecting member has a nut 113, and the piston rod 104 of the nut has an external thread matching the internal thread 104a. 在其接合传动箱的末端,连接部件配备有两个在这个部件的两侧垂直于连接部件112的纵轴伸出的销111。 At the end of their engagement gearbox, the connecting member is equipped with two vertical sides of the components in the longitudinal axis of the connecting member 112 protruding pin 111. 每个销111承载着齿轮114,该齿轮114位于两个齿条110 和115之间并且与这两个齿条110和115接合。 Each pin 111 carrying the gear 114, the gear 114 is located between the two racks 110 and 115 and with the two racks 110 and 115 engaged. 这样,在齿条110 和115相对于彼此移动时,连接部件112将与传动箱一起旋转,但是可以相对于所述传动箱沿轴向位移。 Thus, the racks 110 and 115 with respect to the moving member 112 is connected to each other with the rotation of the transmission case, but with respect to the axial displacement of the transmission case. 在实践中,将会是齿条115相对于传动箱部件109和壳体1移动,并且将会借助所示的构造导致连接部件112相对于壳体移动为齿条115移动距离的一半的距离。 In practice, it will be the rack 115 relative to the gear case member 109 and the housing 1 is moved, and will result in the configuration shown by means of the connecting member 112 to move relative to the housing rack 115 is half the distance to the moving distance. 联接部件125在其外周配备有齿124的瓣状体并且具有设置在壳体101中的中心管上的中心孔,从而这个联接部件125能够沿着所述中心管105 发生轴线位移。 The coupling member 125 is provided with teeth at its outer periphery 124 of the rosette and having a central hole provided in the housing 101 in the center of the pipe, so that the coupling member 125 can occur along the axis of displacement of the center tube 105. 在附图3和4中示出了联接部件125的中心孔上的一个或多个内部凸起128。 On one or more of Figures 3 and 4 illustrate the coupling member inside the center hole 125 of the projection 128. 这些凸起接合中心管内的配套螺旋状凹槽轨道或螺紋137 (附图3和4中未示出),以使得联接部件在旋转运动方面受到限制,就是说,联接部件125随着联接部件125沿着轨道或螺紋137的轴向位移而有角度地移动。 These supporting projections engage helical groove tracks or threaded central tube 137 (Figures 3 and 4 not shown), so that the coupling member is limited in terms of rotational movement, that is, the coupling member 125 with the coupling member 125 while angularly moving along the track or thread 137 of axial displacement. 由于壳体内的这一旋转限制或旋转引导,管状部件120边缘上的齿的瓣状体可以在所述管状部件与剂量设定部件117—起旋转时^哒越过联接部件的齿124。 Due to this rotation limiting rotation guide or housing, rosette of teeth 120 on the edge of the tubular member may be set in the tubular member and the member is rotated from the dose 117- ^ pyridazin teeth 124 over the coupling member. 在联接部件125与设置在剂量设定部件117中的内部台肩127之间发挥作用的弹簧126使得联接部件在管状部件120与剂量设定部件一起在壳体内沿纵向移动时随着管状部件120运动。 In the role of spring coupling member 125 and 127 is provided between the dose setting member 117 in the shoulder 126 inside the tubular member such that the coupling member 120 together with the dose setting member is moved longitudinally within the housing when the tubular member 120 with movement. 为了使剂量设定部件能够容易旋转,尤其是在向壳体内部按压所述剂量设定部件时使设定部件能够容易旋转,具有由台肩127支撑的外环142和支撑用来支撑弹簧126的压力衬套144的内环143的滚柱轴承。 To make the dose setting member can be easily rotated, especially when pressed to the inner housing dose setting means the setting member can be easily rotated by a shoulder 127 having a support for supporting the outer ring 142 and the support spring 126 The pressure bush roller bearing inner ring 143 144. 通过提供这种平滑移动的支撑,在注射设定剂量时,仅需要很小的轴向力就可以将剂量设定部件117旋转回到它的零位置。 By providing such a smooth movement of the support, set the injection dose, it requires only a small axial force may be the dose setting member 117 rotating back to its zero position. 这种解决方案用复位弹簧取代了附图1中的弹簧36。 This solution is replaced by the return spring of the spring 36 of Figure 1. 将轴承表示为径向轴承,但是也可以替换为轴向轴承。 The bearing is represented as a radial bearing, but it can be replaced by axial bearings. 尽管在附图3和4中没有示出轨道137,但是可以在附图5中看到这个轨道,附图5示出了附图3和4中所示的实施方式的分解图。 Although in Figures 3 and 4, the track 137 is not shown, but can be seen in Fig. 5 the track, Figure 5 shows the embodiment of Figures 3 and 4 shown in an exploded view. 此外还在附图6a中以更大的比例示出了中央管状部分105,而附图6b是美国专利US6663602中给出的现有注射装置的相应部分。 Further still figures 6a to a larger scale showing the central tubular portion 105, and a corresponding portion of the prior figures 6b injection apparatus given in U.S. Patent No. US6663602. 表l是表示上面介绍的注射装置的不同构造的列表。 Table l is a list of the different structure of the injection device described above. 在表l中, 构造第1号对应于美国专利US6663602中公开的装置,即,具有不旋转但是能够沿轴向位移的活塞杆并且具有轨道37、 137 (是平行于注射装置的轴线延伸的直线轨道)的装置。 In Table l, the configuration No. 1 corresponds disclosed in U.S. Patent US6663602 in devices that have not yet capable of displacement in the axial rotation of the piston rod and having a track 37, 137 (parallel to the axis of the injection device extends straight track) devices. 构造2-6对应于剂量设定部件上的螺紋6、 106和活塞杆上的第一螺紋4a, 104a的螺距与构造l中相同的实施方式。 2-6 structure corresponding to the dose setting member thread 6, 106 and the first thread on the piston rod 4a, 104a of the pitch and the same structure l embodiments. 在构造2-6中,将轨道37、 137形成为沿着轨道的延伸方向具有恒定螺距的螺旋状轨道,各个这些构造对应于轨道的具体螺距。 In the configuration 2-6, the rails 37, 137 is formed as a spiral track with a constant pitch along the extending direction of the track, each of which corresponds to the specific configuration of the track pitch. 构造1 - 4具有不可旋转但是能够沿轴向位移的活塞杆。 Construction 1--4 have not yet capable of displacement in the axial direction of rotation of the piston rod. 构造5和6具有与壳体中的螺紋开口2b配套并接合的螺旋状轨道4b、 104b。 5 and 6 have the structure housing the threaded opening 2b supporting and engaging the spiral track 4b, 104b. 表l.(正螺距值表示左旋螺紋,负螺距值表示右旋螺紋,O(零) 表示不可纵向旋转的轨道)<table>table see original document page 21</column></row> <table>表2.<table>table see original document page 21</column></row> <table> Table l. (Positive pitch value indicates left-hand thread, negative value indicates the pitch right-hand thread, O (zero) represents a non-rotatable longitudinal track) <table> table see original document page 21 </ column> </ row> <table> Table 2. <table> table see original document page 21 </ column> </ row> <table>

表2列出了针对构造1-6设定剂量不同的例子,其中表2的第三列表示剂量设定转轮17, 117的拨动角度量。 Table 2 lists the set dose for the construction 1-6 different example in which the third column of Table 2 indicates the amount of dose setting wheel slide angle 17, 117. 在列4中列出了剂量设定转轮相对于联接部件25、 125的相应旋转运动量,并且在列5 中列出了结果得到的活塞杆的轴向位移量。 It lists the dose setting wheel with respect to the coupling member rotating the respective exercise 25, 125 in the column 4, and column 5 lists the results of the axial displacement of the piston rod. 比较表2中的例子1 - 3和5,可以明显看出,轨道37, 137螺距的变化改变了排出期望剂量所需要拨动的剂量设定部件的旋转量。 Table 2 Comparative Example 1 - 3 and 5, it is clear that, the track 37, 137 changes the pitch changes the amount of rotation required to discharge a desired dose of the dose setting member toggle. 从而,给出了一种简单的调节方法,这种方法可以改变为了将剂量设定按钮推进一格剂量设定部件所要旋转的旋转量。 Thus, it gives a simple adjustment method that can be changed in order to advance the amount of rotation of the dose setting button a grid dose setting member to be rotated. 而且,这提供了改变剂量刻度上连续数字之间的角距离的可能性。 Moreover, it offers the possibility of changing the dosage scale angular distance between consecutive numbers. 因此,为了获得较大字号的剂量刻度布局,或者可选地获得较小字号的剂量刻度布局,可以据此选择轨道37, 137的螺距。 Therefore, in order to obtain a larger scale font doses layout, or alternatively for a larger size of the dosage scale layout, track 37 could then select, 137 pitch. 比较例子3和6,很容易看出,在活塞杆和壳体之间引入螺紋连接,即,使得活塞杆可相对于壳体旋转,提供了获得剂量设定量得到改变的注射装置的可能性,例如,半量增加的注射装置。 Comparative Examples 3 and 6, it is easy to see that between the piston rod and the housing is introduced threaded connection, i.e., such that rotation of the piston rod relative to the housing, is provided to give access to the dose setting change amount of the possibility of the injection device , e.g., half the amount of increase of the injection device. 当引入相对于壳体旋转的联接部件25、 125时,上面介绍的容量完结结构可能不会以最佳方式起作用。 When introduced into the housing rotating relative to the coupling member 25, 125, the capacity of the end of the structure described above may not be in the best manner. 不过,通过为活塞杆上的附加的纵向延伸轨道4b、 104b选择与轨道37、 137的螺距相同的螺距, 确保了用户在设定注射剂量的时候可以感受到的容量完结限制对应于注射期间排出的确切量。 However, by providing an additional longitudinally extending track on the piston rod 4b, 104b to select and track pitch 37, 137 of the same pitch, to ensure that the set dose the user can feel the time limit corresponding to the end of the discharge capacity during the injection The exact amount. 这样,在注射与容量完结设定(即,活塞杆4、 104相对于螺母13、 113完全缩回的情形)相应的剂量时, 可以完全清空药瓶。 Thus, at the end of the injection and the capacity is set (i.e., the piston rod 4, 104 with respect to the nut 13, the case 113 is fully retracted) when the appropriate dosage, the vial can be completely emptied. 在其它一些实施方式中,可以将轨道37, 137设计成具有沿着该轨道变化的螺距,即,具有带有倾斜或不倾斜延长以及弯曲延长的线性部分。 In other embodiments, the rails 37 may be 137 designed to have a varying pitch along the track, i.e., with an inclined or not inclined with extended linear portion and a curved extension. 而且,轨道的旋转方向可以从轨道"一个部分到轨道的另一个部分发生改变。 一种具体的实施方式可以设计成较小剂量设定对应的相对剂量按钮运动量比与较大剂量相应的剂量设定所对应的按钮运动量要大。从而确保了将较小剂量设定的可辨别性保持在比较高的层次上。虽然前面介绍的实施方式示出了不同的具体传动箱组件,但是应当注意,在本发明的范围内,也可以使用各种不同的其它类型的传动箱。而且,可以省略传动箱的功能,而注射装置仍然处于本发明的范围之内。此外,具有在剂量设定/注射期间保持轴向固定的剂量设定部件求的范围之内。 一种非不限定性的实施方式包括附加的从动部件, 这个部件可旋转地与剂量设定部件联接,并且可以用于在剂量设定引起联接部件的轴向运动。此外,可以采用摩擦联接来取代前面提到的增量反馈机构,从而可以在连续选择的剂量当中设定剂量。本文引用的所有参考文献,包括出版物、专利申请并且专利,都以引用的方式整体并入本文,并且并入的程度是看起来曾经单独且在本文中整体给出的(法;允许的最大程度)J' :所有的标题和副标题都仅仅是为了方便起见而在本文中使用的,不应看作对本发明有任何方式的限定。本文使用的任何和所有的例子或者示例性语言(例如,"比如,,) 仅仅是用来更好地解释本发明,并且并不对本发明的范围造成任何限制,除非另有说明。 Further, the rotational direction of the track change may occur from one part of the track "to another part of the track. A particular embodiment may be designed smaller dose the dose setting button corresponding to the relative movement of a larger dose than the corresponding dose provided corresponding to the button set larger exercise thus ensuring the identifiable set of smaller doses to maintain at a relatively high level. Although the previously described embodiments illustrate different specific gearbox assembly, it should be noted, within the scope of the present invention may also be used various other types of transmission case. Further, the function of the transmission case can be omitted, and the injection device is still within the scope of the present invention. In addition, having a dose setting / injection remain axially fixed within the dose setting member during seek range. A non-limited embodiments include additional qualitative driven member, this member is rotatably coupled to the dose setting member, and may be used at doses Setting causes axial movement of the coupling member. In addition, you can use instead of the incremental frictional feedback mechanism mentioned above, which can set the dose in a continuous dose selected among all the references cited herein, including publications, patent applications and patents are incorporated by reference in its entirety herein, and that seems to have been incorporated into the degree of individual and overall given herein (method; the maximum extent permitted) J ': all the headings and subheadings are merely for convenience and used herein, should not be considered to have limited the present invention in any way. Any and all examples, or exemplary language used (for example, "for example ,,) is only used to better explain the present invention and are not causing any limitation on the scope of the present invention, unless otherwise indicated. 说明书中的任何语言都不应该看作是表明任何未要求保护的零部件对实现本发明是必不可少的。 No language in the specification should not be seen as a show of any non-claimed part of the implementation of the present invention is essential. 专利文件在本文中引用和结合仅仅是为了方便而为之,并不反映任何有关这些专利文献的正确性、可专利性和/或法律可执行性的观点。 Only the patent documents cited herein combined for convenience and to whom, and does not reflect the accuracy of any of these patent documents, patentability and / or legal enforceability of view. 本发明在使用法律允许的前提下包括所附权利要求中列出的主题的所有改造方案和等价方案。 The present invention is in the law permitting the use of themes including the appended claims listed all rehabilitation programs and equivalents.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
CN103179998A *5 Oct 201126 Jun 2013赛诺菲-安万特德国有限公司Drive mechanism for a drug delivery device and drug delivery device
CN103179998B *5 Oct 201124 Feb 2016赛诺菲-安万特德国有限公司用于给药装置的驱动机构和给药装置
Classifications
International ClassificationA61M5/315
Cooperative ClassificationA61M5/3158, A61M5/31558, A61M5/3156, A61M5/31573, A61M5/31541, A61M5/31575, A61M5/31556, A61M5/31551, A61M5/31585, A61M2005/3152, A61M5/31561
European ClassificationA61M5/315F2B1, A61M5/315E2B1A, A61M5/315F2A1
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